CA2378913A1 - System for effecting smoke cessation - Google Patents
System for effecting smoke cessation Download PDFInfo
- Publication number
- CA2378913A1 CA2378913A1 CA002378913A CA2378913A CA2378913A1 CA 2378913 A1 CA2378913 A1 CA 2378913A1 CA 002378913 A CA002378913 A CA 002378913A CA 2378913 A CA2378913 A CA 2378913A CA 2378913 A1 CA2378913 A1 CA 2378913A1
- Authority
- CA
- Canada
- Prior art keywords
- formulation
- nicotine
- containers
- patient
- aerosolizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
- A24F40/42—Cartridges or containers for inhalable precursors
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/06—Packaging for specific medical equipment
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
A system is disclosed which makes it possible for a patient to be delivered gradually reduced amounts of nicotine over time thereby allowing the patient to be gradually weaned off of dependence on nicotine and quit smoking. The system is comprised of a means for aerosolizing a formulation and containers of formulation. The formulation is comprised of nicotine in a pharmaceutically acceptable carrier. Preferably, a plurality of containers are produced wherein the concentration of nicotine in the different containers oR different groups of containers is reduced. The patient uses containers with the highest concentration initially and gradually moves towards using containers with lower and lower concentrations of nicotine until the patient's dependence on nicotine is eliminated.
Claims (21)
1. A system for aiding a patient in quitting smoking, comprising:
a device for aerosolizing a formulation;
a first plurality of containers which are designed for being loaded into the device for aerosolizing formulation wherein the containers are comprised of nicotine and a pharmaceutically acceptable carrier and wherein the nicotine is present in a first concentration;
a second plurality of containers capable of being loaded into the device for aerosolizing formulation wherein the formulation in the second plurality of containers is comprised of nicotine and a pharmaceutically acceptable carrier and further wherein the nicotine is present in the formulation in a second concentration which is less than the first concentration.
a device for aerosolizing a formulation;
a first plurality of containers which are designed for being loaded into the device for aerosolizing formulation wherein the containers are comprised of nicotine and a pharmaceutically acceptable carrier and wherein the nicotine is present in a first concentration;
a second plurality of containers capable of being loaded into the device for aerosolizing formulation wherein the formulation in the second plurality of containers is comprised of nicotine and a pharmaceutically acceptable carrier and further wherein the nicotine is present in the formulation in a second concentration which is less than the first concentration.
2. The system of claim 1, further comprising:
a third plurality of containers which are designed for being loaded into the device for aerosolizing formulation wherein the containers are comprised of nicotine and a pharmaceutically acceptable carrier and wherein the nicotine is present in a third concentration which is less than the second concentration.
a third plurality of containers which are designed for being loaded into the device for aerosolizing formulation wherein the containers are comprised of nicotine and a pharmaceutically acceptable carrier and wherein the nicotine is present in a third concentration which is less than the second concentration.
3. The system as claimed in claim 1, wherein the formulation in the first plurality of containers and the formulation in the second plurality of containers is a liquid flowable formulation wherein the nicotine is present in the formulation in a solution or suspension.
4. The system as claimed in claim 3, wherein the first plurality of containers comprises a porous membrane for each container and further wherein the second plurality of containers comprises a porous membrane for each container.
5. The system as claimed in claim 1, wherein the formulation in the first plurality of containers and the formulation in the second plurality of containers is a dry powder formulation.
The system as claimed in claim 1, wherein the first plurality of containers comprises two or more canisters which canisters contain the formulation in the form of nicotine and low boiling point propellant and wherein the second plurality of containers comprises two or more canisters wherein the formulation in the canisters comprises nicotine and a low boiling point propellant.
7. The system as claimed in claim 1, wherein the device for aerosolizing formulation is a hand-held, self contained device.
8. The system as claimed in claim 1, wherein the first plurality of containers each comprise a porous membrane wherein the pores have a first average size, and wherein the second plurality of containers each comprise a porous membrane wherein the pores have a second average size which is larger than the first average size of the pores in the membrane of the first plurality of containers.
9. A device for aerosolizing a nicotine formulation, comprising:
a means for aerosolizing formulation by applying force; and a means for adjusting the means for aerosolizing formulation so that a different amount of force can be applied based on the adjustment.
a means for aerosolizing formulation by applying force; and a means for adjusting the means for aerosolizing formulation so that a different amount of force can be applied based on the adjustment.
10. The device as claimed in claim 9, further comprising:
a container loaded into the device which container is comprised of a formulation comprised of nicotine and a pharmaceutically acceptable carrier.
a container loaded into the device which container is comprised of a formulation comprised of nicotine and a pharmaceutically acceptable carrier.
11. A kit for aiding a patient in quitting smoking, comprising:
a first plurality of containers having therein nicotine and a pharmaceutically acceptable carrier, wherein the nicotine is present in a first concentration;
a second plurality of containers having therein nicotine and a pharmaceutically acceptable carrier wherein the nicotine is present in a second concentration which is less than the first concentration.
a first plurality of containers having therein nicotine and a pharmaceutically acceptable carrier, wherein the nicotine is present in a first concentration;
a second plurality of containers having therein nicotine and a pharmaceutically acceptable carrier wherein the nicotine is present in a second concentration which is less than the first concentration.
12. The kit as claimed in claim 11, wherein the first plurality of containers and second plurality of containers hold the nicotine and pharmaceutically acceptable carrier in a liquid flowable form.
13. The kit as claimed in claim 11, wherein the first plurality of containers and second plurality of containers each hold the nicotine and pharmaceutically acceptable carrier in a dry powder form.
14. A method of treatment, comprising:
(a) aerosolizing a formulation comprised of nicotine creating aerosolized particles which are sufficiently small as to target the alveoli of a patient's respiratory tract;
(b) allowing the patient to inhale the aerosolized particles of (a) thereby causing nicotine to enter the patient's blood;
(c) repeating (a) and (b) a plurality of times;
(d) aerosolizing a formulation comprised of nicotine creating aerosolized particles which are sized in order to target the bronchioles of the patient's respiratory tract;
(e) allowing the patient to inhale the aerosolized particles of (d) thereby targeting the bronchioles of the respiratory tract; and (f) repeating (d) and (e) a plurality of times.
(a) aerosolizing a formulation comprised of nicotine creating aerosolized particles which are sufficiently small as to target the alveoli of a patient's respiratory tract;
(b) allowing the patient to inhale the aerosolized particles of (a) thereby causing nicotine to enter the patient's blood;
(c) repeating (a) and (b) a plurality of times;
(d) aerosolizing a formulation comprised of nicotine creating aerosolized particles which are sized in order to target the bronchioles of the patient's respiratory tract;
(e) allowing the patient to inhale the aerosolized particles of (d) thereby targeting the bronchioles of the respiratory tract; and (f) repeating (d) and (e) a plurality of times.
15. The method of claim 14, further comprising:
(g) aerosolizing a formulation comprised of nicotine creating aerosolized particles which are sized in order to target the bronchi of the patient's respiratory tract;
(h) allowing the patient to inhale the aerosolized particles of (g) into the bronchi of the respiratory tract; and (i) repeating (g) and (h) a plurality of times.
(g) aerosolizing a formulation comprised of nicotine creating aerosolized particles which are sized in order to target the bronchi of the patient's respiratory tract;
(h) allowing the patient to inhale the aerosolized particles of (g) into the bronchi of the respiratory tract; and (i) repeating (g) and (h) a plurality of times.
16. The method of claim 14, wherein the formulation is a liquid formulation comprising nicotine and an excipient selected from the group consisting of an aqueous solvent to form solutions and a liquid to form suspensions.
17. The method of claim 14, wherein the formulation comprises a solution or suspension of a nicotine and an aqueous solvent or liquid carrier and the aerosolized particles are created by moving the formulation through a porous membrane.
18. A method of treatment, comprising:
(a) aerosolizing a formulation comprising about 0.25 mg or more of nicotine to create aerosolized particles which target an area of a patient's respiratory tract;
(b) allowing the patient to inhale the aerosolized particles of (a) thereby causing nicotine to enter the patient's blood;
(c) repeating (a) and (b) a plurality of times.
(a) aerosolizing a formulation comprising about 0.25 mg or more of nicotine to create aerosolized particles which target an area of a patient's respiratory tract;
(b) allowing the patient to inhale the aerosolized particles of (a) thereby causing nicotine to enter the patient's blood;
(c) repeating (a) and (b) a plurality of times.
19. The method of claim 18, further comprising:
(d) aerosolizing a formulation comprising about 0.25 mg or more of nicotine to create aerosolized particles which target a second area of the patient's respiratory tract;
(e) allowing the patient to inhale the aerosolized particles of (d) to the second area of the patient's respiratory tract; and (f) repeating (d) and (e) a plurality of times.
(d) aerosolizing a formulation comprising about 0.25 mg or more of nicotine to create aerosolized particles which target a second area of the patient's respiratory tract;
(e) allowing the patient to inhale the aerosolized particles of (d) to the second area of the patient's respiratory tract; and (f) repeating (d) and (e) a plurality of times.
20. A method comprising the steps of:
(a) aerosolizing a formulation comprised of nicotine creating aerosolized particles having a diameter of 0.5 µ, to about 2 µ;
(b) allowing the patient to inhale the aerosolized particles of (a) into the patient's respiratory tract;
(c) repeating (a) and (b) a plurality of times;
(d) aerosolizing a formulation comprised of nicotine creating aerosolized particles having a diameter of 2 µ to about 4 µ;
(e) allowing the patient to inhale the aerosolized particles of (d) into the patient's respiratory tract; and (f) repeating (d) and (e) a plurality of times.
(a) aerosolizing a formulation comprised of nicotine creating aerosolized particles having a diameter of 0.5 µ, to about 2 µ;
(b) allowing the patient to inhale the aerosolized particles of (a) into the patient's respiratory tract;
(c) repeating (a) and (b) a plurality of times;
(d) aerosolizing a formulation comprised of nicotine creating aerosolized particles having a diameter of 2 µ to about 4 µ;
(e) allowing the patient to inhale the aerosolized particles of (d) into the patient's respiratory tract; and (f) repeating (d) and (e) a plurality of times.
21. The method of claim 20, further comprising the steps of:
(g) aerosolizing a formulation comprised of nicotine creating aerosolized particles having a diameter of 4 µ, to about 8 µ;
(h) allowing the patient to inhale the aerosolized particles of (g) into the patient's respiratory tract; and (i) repeating (g) and (h) a plurality of times.
(g) aerosolizing a formulation comprised of nicotine creating aerosolized particles having a diameter of 4 µ, to about 8 µ;
(h) allowing the patient to inhale the aerosolized particles of (g) into the patient's respiratory tract; and (i) repeating (g) and (h) a plurality of times.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14414099P | 1999-07-16 | 1999-07-16 | |
US60/144,140 | 1999-07-16 | ||
PCT/US2000/019034 WO2001005459A1 (en) | 1999-07-16 | 2000-07-12 | System for effecting smoke cessation |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2378913A1 true CA2378913A1 (en) | 2001-01-25 |
CA2378913C CA2378913C (en) | 2010-02-23 |
Family
ID=22507255
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2378913A Expired - Fee Related CA2378913C (en) | 1999-07-16 | 2000-07-12 | System for effecting smoke cessation |
Country Status (6)
Country | Link |
---|---|
US (1) | US20020179102A1 (en) |
EP (1) | EP1218048A4 (en) |
JP (1) | JP4999245B2 (en) |
AU (1) | AU777326B2 (en) |
CA (1) | CA2378913C (en) |
WO (1) | WO2001005459A1 (en) |
Families Citing this family (37)
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JP2005503425A (en) | 2001-05-24 | 2005-02-03 | アレックザ モレキュラー デリヴァリー コーポレイション | Delivery of drug ester by the prescribed inhalation route |
US6759029B2 (en) | 2001-05-24 | 2004-07-06 | Alexza Molecular Delivery Corporation | Delivery of rizatriptan and zolmitriptan through an inhalation route |
US6805853B2 (en) | 2001-11-09 | 2004-10-19 | Alexza Molecular Delivery Corporation | Delivery of diazepam through an inhalation route |
US20030051728A1 (en) | 2001-06-05 | 2003-03-20 | Lloyd Peter M. | Method and device for delivering a physiologically active compound |
AU2002363947A1 (en) | 2001-11-21 | 2003-07-24 | Alexza Molecular Delivery Corporation | Delivery of caffeine through an inhalation route |
CN100381083C (en) | 2003-04-29 | 2008-04-16 | 韩力 | Electronic nonflammable spraying cigarette |
WO2004104490A1 (en) | 2003-05-21 | 2004-12-02 | Alexza Pharmaceuticals, Inc. | Self-contained heating unit and drug-supply unit employing same |
CN2719043Y (en) | 2004-04-14 | 2005-08-24 | 韩力 | Atomized electronic cigarette |
WO2006004646A1 (en) * | 2004-06-28 | 2006-01-12 | Nektar Therapeutics | Aerosol formulation comprising nicotine salt |
FR2873584B1 (en) * | 2004-08-02 | 2006-11-17 | Jean Jacques Hubinois | TOBACCO WEANING SYSTEM |
US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
EP1802258A4 (en) | 2004-09-13 | 2015-09-23 | Chrono Therapeutics Inc | Biosynchronous transdermal drug delivery |
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US10679516B2 (en) | 2015-03-12 | 2020-06-09 | Morningside Venture Investments Limited | Craving input and support system |
US10433580B2 (en) | 2016-03-03 | 2019-10-08 | Altria Client Services Llc | Methods to add menthol, botanic materials, and/or non-botanic materials to a cartridge, and/or an electronic vaping device including the cartridge |
US10455863B2 (en) | 2016-03-03 | 2019-10-29 | Altria Client Services Llc | Cartridge for electronic vaping device |
US10368580B2 (en) | 2016-03-08 | 2019-08-06 | Altria Client Services Llc | Combined cartridge for electronic vaping device |
US10368581B2 (en) | 2016-03-11 | 2019-08-06 | Altria Client Services Llc | Multiple dispersion generator e-vaping device |
US10357060B2 (en) | 2016-03-11 | 2019-07-23 | Altria Client Services Llc | E-vaping device cartridge holder |
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GB2604314A (en) | 2017-09-22 | 2022-09-07 | Nerudia Ltd | Device, system and method |
EP3758528A1 (en) * | 2018-02-26 | 2021-01-06 | Nerudia Limited | Device, system and method |
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US5906202A (en) * | 1996-11-21 | 1999-05-25 | Aradigm Corporation | Device and method for directing aerosolized mist to a specific area of the respiratory tract |
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-
2000
- 2000-07-12 WO PCT/US2000/019034 patent/WO2001005459A1/en active IP Right Grant
- 2000-07-12 CA CA2378913A patent/CA2378913C/en not_active Expired - Fee Related
- 2000-07-12 JP JP2001510544A patent/JP4999245B2/en not_active Expired - Fee Related
- 2000-07-12 AU AU59312/00A patent/AU777326B2/en not_active Ceased
- 2000-07-12 EP EP00945354A patent/EP1218048A4/en not_active Withdrawn
-
2002
- 2002-06-17 US US10/174,000 patent/US20020179102A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2378913C (en) | 2010-02-23 |
JP2003504165A (en) | 2003-02-04 |
EP1218048A4 (en) | 2009-08-26 |
AU5931200A (en) | 2001-02-05 |
JP4999245B2 (en) | 2012-08-15 |
US20020179102A1 (en) | 2002-12-05 |
AU777326B2 (en) | 2004-10-14 |
EP1218048A1 (en) | 2002-07-03 |
WO2001005459A1 (en) | 2001-01-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20180712 |