CA2384822A1 - System and method for tomographic imaging of dynamic properties of a scattering medium - Google Patents

System and method for tomographic imaging of dynamic properties of a scattering medium Download PDF

Info

Publication number
CA2384822A1
CA2384822A1 CA002384822A CA2384822A CA2384822A1 CA 2384822 A1 CA2384822 A1 CA 2384822A1 CA 002384822 A CA002384822 A CA 002384822A CA 2384822 A CA2384822 A CA 2384822A CA 2384822 A1 CA2384822 A1 CA 2384822A1
Authority
CA
Canada
Prior art keywords
medium
optical energy
tomographic imaging
dynamic properties
scattering medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002384822A
Other languages
French (fr)
Other versions
CA2384822C (en
Inventor
Randall L. Barbour
Christoph H. Schmitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of State University of New York
Original Assignee
Randall L. Barbour
Christoph H. Schmitz
The Research Foundation Of State University Of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Randall L. Barbour, Christoph H. Schmitz, The Research Foundation Of State University Of New York filed Critical Randall L. Barbour
Publication of CA2384822A1 publication Critical patent/CA2384822A1/en
Application granted granted Critical
Publication of CA2384822C publication Critical patent/CA2384822C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/4795Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium

Landscapes

  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

A system and method for the detection and three dimensional imaging of absorption and scattering properties of a medium such as human tissue is described. According to one embodiment of the invention, the system directs optical energy toward a turbid medium from at least one source and detects optical energy emerging from the turbid medium at a plurality of locations uisng at least one detector (106). The optical energy emerging from the medium (102) and entering the detector (106) originates from the source (101) is scattered by the medium (102). The system then generates an image representing interior structure of the turbid medium based on the detected optical energy emerging from the medium (102). Generating the image includes a time-series analysis.
CA002384822A 1999-09-14 2000-09-14 System and method for tomographic imaging of dynamic properties of a scattering medium Expired - Fee Related CA2384822C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15392699P 1999-09-14 1999-09-14
US60/153,926 1999-09-14
US15409999P 1999-09-15 1999-09-15
US60/154,099 1999-09-15
PCT/US2000/025155 WO2001020306A1 (en) 1999-09-14 2000-09-14 System and method for tomographic imaging of dynamic properties of a scattering medium

Publications (2)

Publication Number Publication Date
CA2384822A1 true CA2384822A1 (en) 2001-03-22
CA2384822C CA2384822C (en) 2007-01-02

Family

ID=26850998

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002384822A Expired - Fee Related CA2384822C (en) 1999-09-14 2000-09-14 System and method for tomographic imaging of dynamic properties of a scattering medium
CA2384813A Expired - Fee Related CA2384813C (en) 1999-09-14 2000-09-14 Method and system for imaging the dynamics of scattering medium

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2384813A Expired - Fee Related CA2384813C (en) 1999-09-14 2000-09-14 Method and system for imaging the dynamics of scattering medium

Country Status (6)

Country Link
US (1) USRE41949E1 (en)
EP (2) EP1221034B1 (en)
JP (3) JP2003509687A (en)
AU (2) AU7579500A (en)
CA (2) CA2384822C (en)
WO (2) WO2001020306A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2319397B1 (en) * 2001-06-22 2013-06-05 Nellcor Puritan Bennett Ireland Wavelet-based analysis of pulse oximetry signals
WO2003012736A2 (en) * 2001-08-02 2003-02-13 The Research Foundation Of State University Of Ne W York Method and system for enhancing solutions to a system of linear equations
US6662128B2 (en) 2002-01-18 2003-12-09 The Research Foundation Of State University Of New York Normalized-constraint algorithm for minimizing inter-parameter crosstalk in imaging of scattering media
CA2481518A1 (en) 2002-04-06 2003-10-23 Randall L. Barbour A system and method for quantifying the dynamic response of a target system
WO2003088133A1 (en) 2002-04-06 2003-10-23 Barbour Randall L Modification of the normalized difference method for real-time optical tomography
WO2005006962A2 (en) 2003-07-18 2005-01-27 Nirx Medical Technologies, L.L.C. Image enhancement by spatial linear deconvolution
JP2007522133A (en) * 2004-01-23 2007-08-09 エスアールアイ インターナショナル Optical vascular function imaging system and cancerous tumor detection and diagnosis method
US7471975B2 (en) * 2004-09-22 2008-12-30 The Research Foundation Of State University Of New York Optical tensor imaging
DE102005039184B4 (en) 2005-08-18 2011-05-19 Siemens Ag Method for evaluating a cinematographic image series of the heart, magnetic resonance tomography apparatus and computer program
EP1954178B1 (en) * 2005-11-23 2018-08-22 Koninklijke Philips N.V. A method and device for imaging an interior of a turbid medium
CN101404925A (en) * 2006-03-17 2009-04-08 皇家飞利浦电子股份有限公司 A device for imaging a turbid medium
KR101041295B1 (en) * 2006-03-31 2011-06-14 가부시키가이샤 시마즈세이사쿠쇼 Mammography system
EP2120687A1 (en) * 2006-12-19 2009-11-25 Koninklijke Philips Electronics N.V. Imaging of a turbid medium
CA2781393C (en) 2009-11-19 2017-08-08 Modulated Imaging, Inc. Method and apparatus for analysis of turbid media via single-element detection using structured illumination
WO2012065140A2 (en) 2010-11-11 2012-05-18 The Trustees Of Columbia University In The City Of New York Dynamic optical tomographic imaging devices methods and systems
BR112015010459B1 (en) 2012-11-07 2021-01-26 Modulated Imaging, Inc. method for measuring a cloudy sample
USD763938S1 (en) 2014-04-02 2016-08-16 Cephalogics, LLC Optical sensor array
USD763939S1 (en) 2014-04-02 2016-08-16 Cephalogics, LLC Optical sensor array liner with optical sensor array pad
US9599697B2 (en) 2014-04-15 2017-03-21 The Johns Hopkins University Non-contact fiber optic localization and tracking system

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810875A (en) * 1987-02-02 1989-03-07 Wyatt Technology Corporation Method and apparatus for examining the interior of semi-opaque objects
US5137355A (en) * 1988-06-08 1992-08-11 The Research Foundation Of State University Of New York Method of imaging a random medium
US5353799A (en) * 1991-01-22 1994-10-11 Non Invasive Technology, Inc. Examination of subjects using photon migration with high directionality techniques
US5365066A (en) * 1989-01-19 1994-11-15 Futrex, Inc. Low cost means for increasing measurement sensitivity in LED/IRED near-infrared instruments
US5386819A (en) * 1990-03-29 1995-02-07 Olympus Optical Co., Ltd. Method and apparatus for inhibiting a scattered component in a light having passed through an examined object
JPH04249746A (en) * 1990-12-31 1992-09-04 Shimadzu Corp Reconstructing method of tomographic image
JP3217386B2 (en) * 1991-04-24 2001-10-09 オリンパス光学工業株式会社 Diagnostic system
US6485413B1 (en) * 1991-04-29 2002-11-26 The General Hospital Corporation Methods and apparatus for forward-directed optical scanning instruments
WO1994005209A1 (en) * 1992-08-31 1994-03-17 Hitachi, Ltd. Optical ct apparatus
US5762609A (en) * 1992-09-14 1998-06-09 Sextant Medical Corporation Device and method for analysis of surgical tissue interventions
US5676141A (en) * 1993-03-31 1997-10-14 Nellcor Puritan Bennett Incorporated Electronic processor for pulse oximeters
JP3234353B2 (en) * 1993-06-15 2001-12-04 富士写真フイルム株式会社 Tomographic information reader
US5820558A (en) * 1994-12-02 1998-10-13 Non-Invasive Technology, Inc. Optical techniques for examination of biological tissue
JP3433508B2 (en) * 1993-12-01 2003-08-04 浜松ホトニクス株式会社 Scattering absorber measurement method and scattering absorber measuring device
US5803909A (en) * 1994-10-06 1998-09-08 Hitachi, Ltd. Optical system for measuring metabolism in a body and imaging method
US5625458A (en) * 1994-11-10 1997-04-29 Research Foundation Of City College Of New York Method and system for imaging objects in turbid media using diffusive fermat photons
DE69627477T2 (en) * 1995-01-03 2004-03-18 Non-Invasive Technology, Inc. OPTICAL COUPLING DEVICE FOR IN-VIVO EXAMINATION OF BIOLOGICAL TISSUES
MX9801351A (en) * 1995-08-24 1998-07-31 Purdue Research Foundation Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media.
DE19681107B4 (en) * 1995-11-17 2006-01-26 Hitachi, Ltd. Instrument for optical measurement in a living body
US6108576A (en) * 1996-03-18 2000-08-22 The Research Foundation Of City College Of New York Time-resolved diffusion tomographic 2D and 3D imaging in highly scattering turbid media
EP0897282A2 (en) * 1996-12-03 1999-02-24 Koninklijke Philips Electronics N.V. Method and apparatus for imaging an interior of a turbid medium
US6091983A (en) * 1997-02-07 2000-07-18 Alfano; Robert R. Imaging of objects in turbid media based upon the preservation of polarized luminescence emitted from contrast agents
US5994690A (en) * 1997-03-17 1999-11-30 Kulkarni; Manish D. Image enhancement in optical coherence tomography using deconvolution
US6081322A (en) * 1997-10-16 2000-06-27 Research Foundation Of State Of New York NIR clinical opti-scan system
WO1999026526A1 (en) * 1997-11-22 1999-06-03 Koninklijke Philips Electronics N.V. Method of localizing an object in a turbid medium
EP1054619B1 (en) * 1998-02-11 2007-11-21 Non-Invasive Technology, Inc. Imaging and characterization of brain tissue
AU763861B2 (en) * 1998-05-19 2003-07-31 Spectrx, Inc. Apparatus and method for determining tissue characteristics
US6377842B1 (en) * 1998-09-22 2002-04-23 Aurora Optics, Inc. Method for quantitative measurement of fluorescent and phosphorescent drugs within tissue utilizing a fiber optic probe
ATE268901T1 (en) * 1999-01-29 2004-06-15 June Iris Medford OPTICAL COHERENCE MICROSCOPE AND METHOD FOR RAPID 3D IN-VIVO VISUALIZATION OF BIOLOGICAL FUNCTIONS

Also Published As

Publication number Publication date
USRE41949E1 (en) 2010-11-23
WO2001020305A9 (en) 2002-09-26
CA2384822C (en) 2007-01-02
EP1221034A4 (en) 2009-06-24
WO2001020306A1 (en) 2001-03-22
JP5047432B2 (en) 2012-10-10
CA2384813A1 (en) 2001-03-22
JP2003527883A (en) 2003-09-24
WO2001020306A9 (en) 2002-09-26
JP2003509687A (en) 2003-03-11
JP2012053053A (en) 2012-03-15
WO2001020305A1 (en) 2001-03-22
EP1221035B1 (en) 2012-05-23
EP1221034B1 (en) 2013-05-22
EP1221035A4 (en) 2009-07-01
AU7579300A (en) 2001-04-17
EP1221035A1 (en) 2002-07-10
CA2384813C (en) 2014-01-21
EP1221034A1 (en) 2002-07-10
AU7579500A (en) 2001-04-17

Similar Documents

Publication Publication Date Title
CA2384822A1 (en) System and method for tomographic imaging of dynamic properties of a scattering medium
WO2001001167A3 (en) High resolution imaging system for detecting photons
WO2004054439A3 (en) Optical examination method and apparatus particularly useful for real-time discrimination of tumors from normal tissues during surgery
WO2003102518A3 (en) Terahertz imaging system and method
WO1999039189A3 (en) Gated transmission and scatter detection for x-ray imaging
WO2001072216A3 (en) Methods and apparatus for diagnositic multispectral digital imaging
AU2908397A (en) Apparatus for imaging microvascular blood flow
US20090263759A1 (en) Method and apparatus for detecting abnormality in tooth structure
EP1231496A3 (en) Optical coherence tomography assisted surgical apparatus
WO2002056765A3 (en) System and method for enabling simultaneous calibration and imaging of a medium
WO2002082065A3 (en) Computed tomography apparatus
WO2002091023A3 (en) Nautical x-ray inspection system
WO2000037928A3 (en) Unilateral hand-held x-ray inspection apparatus
WO1996035372A3 (en) A system for quantitative radiographic imaging
AU2808597A (en) Device and method for classification of tissue
CA2174719A1 (en) A robust accurate non-invasive analyte monitor
RU2010131017A (en) IMPROVED SECURITY SYSTEM FOR PREVENTING PEOPLE
CA2238958A1 (en) Method and apparatus for facilitating compatibility between pulse oximeters and sensor probes
WO2004000123A3 (en) High spatial resolution x-ray computed tomography (ct) system
CA2221864A1 (en) Active pulse blood constituent monitoring
EP1008326A3 (en) Photosonic diffusion wave-based tumor detector
WO1999030485A3 (en) X-ray examination apparatus
WO2005023114A3 (en) Computer tomography method using a cone-shaped bundle of rays
AU3102199A (en) Multidimensional detection and characterization of pathologic tissues
WO2004002316A8 (en) Computed tomography apparatus

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20160914