CA2388342A1 - Composition for restoring defects in calcified tissues - Google Patents
Composition for restoring defects in calcified tissues Download PDFInfo
- Publication number
- CA2388342A1 CA2388342A1 CA002388342A CA2388342A CA2388342A1 CA 2388342 A1 CA2388342 A1 CA 2388342A1 CA 002388342 A CA002388342 A CA 002388342A CA 2388342 A CA2388342 A CA 2388342A CA 2388342 A1 CA2388342 A1 CA 2388342A1
- Authority
- CA
- Canada
- Prior art keywords
- calcium
- silicate
- source
- solution
- amorphous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/15—Compositions characterised by their physical properties
- A61K6/17—Particle size
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
- A61K6/69—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/70—Preparations for dentistry comprising inorganic additives
- A61K6/71—Fillers
- A61K6/77—Glass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
- A61K6/807—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics comprising magnesium oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
- A61K6/816—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics comprising titanium oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
- A61K6/824—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics comprising transition metal oxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
- A61K6/838—Phosphorus compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/853—Silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/876—Calcium oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
Abstract
A composition for restoring defects in calcified tissues comprises an amorphous bioactive particulate consisting essentially of calcium, silicon and oxygen. Said agent may be selected from the group consisting of : a) a reaction product of an organic silicate source and a source of calcium; b) a calcium containing hydrolysis product of tetraethylorthosilicate; c) a calcium containing silica sol-gel; d) a binary calcium oxide and silicate precipitated material; e) a synthetic analog of a naturally occurring wollastonite-like calcium silicate; and f) a precipitated reaction product of soluble calcium source and a silicate solution. A process for producing the amorphous bioactive particulate consists essentially of adding a sufficient amount of a solution of a soluble calcium source to a solution of a silicate or silicate precursor to cause a precipitation of calcium-containing silicate particulate.
Claims (20)
1. A composition for restoring defects in calcified tissues comprising an amorphous bioactive particulate material consisting essentially of calcium, silicon and oxygen.
2. A composition according to claim 1 wherein said amorphous material is selected from the group consisting of:
a) a reaction product of an organic silicate source and a source of calcium;
b) a calcium containing hydrolysis product of tetraethylorthosilicate;
c) a calcium containing silica sol-gel;
d) a binary calcium oxide and silicate precipitated material;
e) a synthetic analog of a naturally occurring wollastonite-like calcium silicate; and f) a precipitated reaction product of a soluble calcium source and a silicate solution.
a) a reaction product of an organic silicate source and a source of calcium;
b) a calcium containing hydrolysis product of tetraethylorthosilicate;
c) a calcium containing silica sol-gel;
d) a binary calcium oxide and silicate precipitated material;
e) a synthetic analog of a naturally occurring wollastonite-like calcium silicate; and f) a precipitated reaction product of a soluble calcium source and a silicate solution.
3. A composition according to claim 2 wherein said amorphous material is a precipitated reaction product of a soluble calcium source and a dilute silicate source selected from an aqueous potassium solution or a sodium silicate solution.
4. A composition according to any of claims 1 to 3, in which the said material has a particle size in the range of about 10 microns or less.
5. A composition according to claim 4, in which the material mostly comprises particles in the size range of about 2 microns or less.
6. A composition according to any of claims 1 to 5 in a dental product to alleviate tooth sensitivity due to the presence of exposed dentinal surface and open dentinal tubules, by causing the formation of calcium containing mineral within dentinal tubules of the sensitive teeth.
7. A composition according to claim 6 comprising a carrier and about 1-25% of said amorphous material.
8. A composition according to claim 7 wherein the carrier comprises 0-30%
water, 0-90%
glycerol and 0-80% sorbitol.
water, 0-90%
glycerol and 0-80% sorbitol.
9. A composition according to claim 7 or claim 8 wherein said amorphous material is about 5-10% of the composition and the composition is a dentifrice.
10. Use of an amorphous bioactive particulate consisting essentially of calcium, silicon and oxygen, in the preparation of product to restore defects in calcified tissues.
11. A use according to claim 10 in the preparation of product to alleviate tooth sensitivity due to the presence of exposed dentinal surface and open dentinal tubules by causing the formation of calcium containing mineral within dentinal tubules of the sensitive teeth.
12. A use according to claim 10 or claim 11 wherein said amorphous material is selected from the group consisting of:
a) a reaction product of an organic silicate source and a source of calcium;
b) a calcium containing hydrolysis product of tetraethylorthosilicate;
c) a calcium containing silica sol-gel;
d) a binary calcium oxide and silicate precipitated material;
e) a synthetic analog of a naturally occurring wollastonite-like calcium silicate; and f) a precipitated reaction product of a soluble calcium source and a silicate solution.
a) a reaction product of an organic silicate source and a source of calcium;
b) a calcium containing hydrolysis product of tetraethylorthosilicate;
c) a calcium containing silica sol-gel;
d) a binary calcium oxide and silicate precipitated material;
e) a synthetic analog of a naturally occurring wollastonite-like calcium silicate; and f) a precipitated reaction product of a soluble calcium source and a silicate solution.
13. An amorphous bioactive particulate consisting essentially of calcium, silicon and oxygen, for restoring defects in calcified tissues.
14. An amorphous bioactive particulate according to claim 13, for use in the desensitizing of teeth.
15. An amorphous bioactive particulate according to claim 13 or claim 14 selected from the group consisting of:
a) a reaction product of an organic silicate source and a source of calcium;
b) a calcium containing hydrolysis product of tetraethylorthosilicate;
c) a calcium containing silica sol-gel;
d) a binary calcium oxide and silicate precipitated material;
e) a synthetic analog of a naturally occurring wollastonite-like calcium silicate; and f) a precipitated reaction product of a soluble calcium source and a silicate solution.
a) a reaction product of an organic silicate source and a source of calcium;
b) a calcium containing hydrolysis product of tetraethylorthosilicate;
c) a calcium containing silica sol-gel;
d) a binary calcium oxide and silicate precipitated material;
e) a synthetic analog of a naturally occurring wollastonite-like calcium silicate; and f) a precipitated reaction product of a soluble calcium source and a silicate solution.
16. A process for producing an amorphous bioactive particulate for restoring defects in calcified tissues, said process consisting essentially of adding a sufficient amount of a solution of a soluble calcium source to a solution of a silicate or silicate precursor to cause a precipitation of calcium-containing silicate particulates.
17. A process according to claim 16, wherein said soluble calcium source is selected from the group consisting of calcium salts and alkoxide derivatives and mixtures thereof.
18. A process according to claim 16 or claim 17, wherein said solution of a silicate or silicate precursor is a dilute silicate source selected from the group of aqueous potassium solution and aqueous sodium silicate solution.
19. A process for the production of an amorphous bioactive particulate for the treatment of sensitive teeth, said process consisting essentially of combining a metal alkoxide with water and a catalyst and polymerization of a silicate ester for the production of said amorphous bioactive particulate.
20. A process according to claim 19, wherein said metal alkoxide is prepared from tetraethoxysilane and silanol terminated poly(dimethylsiloxane).
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14743899P | 1999-08-05 | 1999-08-05 | |
US60/147,438 | 1999-08-05 | ||
US09/419,514 | 1999-10-18 | ||
US09/419,514 US20020037258A1 (en) | 1999-08-05 | 1999-10-18 | Dental composition for the mineral occlusion of dentinal tubules in sensitive teeth |
PCT/GB2000/003015 WO2001010392A2 (en) | 1999-08-05 | 2000-08-04 | Composition for restoring defects in calcified tissues |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2388342A1 true CA2388342A1 (en) | 2001-02-15 |
CA2388342C CA2388342C (en) | 2010-09-14 |
Family
ID=26844940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2388342A Expired - Fee Related CA2388342C (en) | 1999-08-05 | 2000-08-04 | Composition for restoring defects in calcified tissues |
Country Status (17)
Country | Link |
---|---|
US (1) | US20020037258A1 (en) |
EP (1) | EP1202705B1 (en) |
JP (1) | JP2003506391A (en) |
KR (1) | KR20020032546A (en) |
CN (1) | CN1377252A (en) |
AT (1) | ATE380012T1 (en) |
AU (1) | AU6455700A (en) |
BR (1) | BR0012971A (en) |
CA (1) | CA2388342C (en) |
CZ (1) | CZ2002438A3 (en) |
DE (1) | DE60037319T2 (en) |
EA (1) | EA200200115A1 (en) |
ES (1) | ES2296631T3 (en) |
HU (1) | HUP0203667A2 (en) |
PL (1) | PL364721A1 (en) |
PT (1) | PT1202705E (en) |
WO (1) | WO2001010392A2 (en) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7323160B2 (en) | 1999-08-14 | 2008-01-29 | Teldent Ltd. | Method of treating a patient's teeth using fluoride releasing glass composition |
EP1333796A4 (en) * | 2000-10-13 | 2004-12-01 | Block Drug Co | Anhydrous dentifrice formulations for the delivery of incompatible ingredients |
US7204874B2 (en) * | 2001-10-24 | 2007-04-17 | Pentron Clinical Technologies, Llc | Root canal filling material |
US7303817B2 (en) * | 2001-10-24 | 2007-12-04 | Weitao Jia | Dental filling material |
US7204875B2 (en) * | 2001-10-24 | 2007-04-17 | Pentron Clinical Technologies, Llc | Dental filling material |
US7750063B2 (en) | 2001-10-24 | 2010-07-06 | Pentron Clinical Technologies, Llc | Dental filling material |
US7211136B2 (en) * | 2001-10-24 | 2007-05-01 | Pentron Clinical Technologies, Llc | Dental filling material |
US20030198616A1 (en) * | 2002-04-23 | 2003-10-23 | Combe Incorporated | Moisturizing skin gel and method |
WO2006050365A2 (en) * | 2004-10-28 | 2006-05-11 | The Regents Of The University Of Michigan | Methods for production of synthetic hydroxyapatite nanorods |
GB0508174D0 (en) * | 2005-04-22 | 2005-06-01 | Psimedica Ltd | Oral hygiene compositions |
US10130561B2 (en) * | 2006-01-31 | 2018-11-20 | Robert L. Karlinsey | Functionalized calcium phosphate hybrid systems for confectionery and foodstuff applications |
US20070258916A1 (en) * | 2006-04-14 | 2007-11-08 | Oregon Health & Science University | Oral compositions for treating tooth hypersensitivity |
US20080025926A1 (en) * | 2006-07-24 | 2008-01-31 | Dr. Nick's White & Healthy, Llc | Oral care formulations with hydrogen peroxide and lycopene |
WO2008017203A1 (en) * | 2006-08-01 | 2008-02-14 | Unilever Plc | Biomaterials, their preparation and use |
DE102006046952A1 (en) * | 2006-10-04 | 2008-04-10 | Ley, Fritz, Dr. | Dental, in particular remineralizing and pain-sensitive teeth effective composition and dental particles, in particular for the composition |
PL2089040T3 (en) * | 2006-12-05 | 2012-06-29 | Unilever Nv | Oral care product |
US9023373B2 (en) * | 2007-01-31 | 2015-05-05 | Indiana Nanotech | Functionalized calcium phosphate hybrid systems for the remineralization of teeth and a method for producing the same |
US8556553B2 (en) * | 2007-02-06 | 2013-10-15 | Indiana Nanotech Llc | Hybrid organic/inorganic chemical hybrid systems, including functionalized calcium phosphate hybrid systems, and a solid-state method for producing the same |
US9205036B2 (en) | 2007-01-31 | 2015-12-08 | Robert Karlinsey | Dental composition |
US20080267891A1 (en) * | 2007-04-30 | 2008-10-30 | Colgate-Palmolive Company | Oral Care Composition To Reduce Or Eliminate Dental Sensitivity |
US20080268001A1 (en) * | 2007-04-30 | 2008-10-30 | Lynette Zaidel | Oral care composition to reduce or eliminate dental sensitivity |
US20090186090A1 (en) * | 2007-04-30 | 2009-07-23 | Colgate-Palmolive | Oral Care Composition to Reduce or Eliminate Dental Sensitivity |
US20080299054A1 (en) * | 2007-05-30 | 2008-12-04 | Conopco, Inc., D/B/A Unilever | Personal care compositions with enhanced fragrance delivery |
JP6034549B2 (en) | 2008-02-08 | 2016-11-30 | コルゲート・パーモリブ・カンパニーColgate−Palmolive Company | Oral care products and methods of use and manufacture thereof |
MX2010004647A (en) * | 2008-02-08 | 2010-06-07 | Colgate Palmolive Co | Oral care product and methods of use thereof. |
US20090317339A1 (en) * | 2008-06-23 | 2009-12-24 | Deepak Sharma | Teeth Bleaching Compositions and Devices |
US7919107B2 (en) * | 2008-07-28 | 2011-04-05 | Sudzucker Aktiengesellschaft Mannhein/Ochsenfurt | Method for treating hypersensitive teeth |
US9226895B2 (en) * | 2008-07-30 | 2016-01-05 | Ultradent Products, Inc. | Methods and kits for cleaning and remineralizing teeth |
US20100047742A1 (en) * | 2008-08-25 | 2010-02-25 | Pitcock Jr William Henry | Tubule-blocking silica materials for dentifrices |
US8603441B2 (en) * | 2008-09-12 | 2013-12-10 | Indiana Nanotech Llc | Functionalized calcium phosphate hybrid systems for confectionery and foodstuff applications |
CN102387775A (en) | 2009-04-01 | 2012-03-21 | 高露洁-棕榄公司 | Dentifrice compositions and methods for treating and preventing damage to tooth surfaces |
US8758729B2 (en) | 2009-05-18 | 2014-06-24 | Colgate-Palmolive Company | Oral compositions containing polyguanidinium compounds and methods of manufacture and use thereof |
JP5210266B2 (en) * | 2009-08-26 | 2013-06-12 | シンジー ディン | Calcium silicate composite cement and preparation method thereof |
TWI499430B (en) | 2009-12-17 | 2015-09-11 | Colgate Palmolive Co | Anti-erosion toothpaste composition |
CN103200994B (en) | 2010-01-29 | 2016-02-10 | 高露洁-棕榄公司 | For the oral care product of sensitive enamel nursing |
US8658139B1 (en) | 2010-02-27 | 2014-02-25 | Squigle, Inc. | Prevention and treatment of oral diseases |
CN103228246A (en) * | 2010-12-07 | 2013-07-31 | 高露洁-棕榄公司 | Dentifrice compositions containing calcium silicate |
US9717929B2 (en) * | 2010-12-07 | 2017-08-01 | Colgate-Palmolive Company | Dentifrice compositions containing calcium silicate and a basic amino acid |
US9724277B2 (en) * | 2011-04-04 | 2017-08-08 | Robert L. Karlinsey | Microbeads for dental use |
US20140248322A1 (en) * | 2011-04-04 | 2014-09-04 | Robert L. Karlinsey | Dental compositions containing silica microbeads |
TWI483740B (en) * | 2011-09-23 | 2015-05-11 | Sancastle Worldwide Corp | Composition for prophylaxising or treating dentin-associated symptoms or diseases, and mthod using the same |
US9901755B2 (en) | 2011-09-23 | 2018-02-27 | Sancastle Worldwide Corporation | Composition for preventing or treating dentin-associated symptoms or diseases, and method using the same |
EP2630944A1 (en) * | 2012-02-23 | 2013-08-28 | Edmund Herzog | Silicon-based particle composition |
BR112015006809B1 (en) * | 2012-10-12 | 2020-04-14 | Unilever Nv | oral care composition, remineralization method and / or teeth whitening and manufacturing process of an oral care composition |
CN104703575B (en) * | 2012-10-12 | 2017-12-12 | 荷兰联合利华有限公司 | Oral care composition |
CN102908663A (en) * | 2012-10-25 | 2013-02-06 | 无锡市三力胶带厂 | Silicon-atom and apatite doped composite high-polymer material and preparation method thereof |
GB201318858D0 (en) * | 2013-10-25 | 2013-12-11 | Glaxosmithkline Biolog Sa | Calcium fluoride compositions |
CN107624064B (en) * | 2015-05-13 | 2021-06-15 | 荷兰联合利华有限公司 | Oral care compositions |
BR112017021670B1 (en) * | 2015-05-13 | 2021-06-01 | Unilever Ip Holdings B.V. | COMPOSITION FOR ORAL CARE, METHOD FOR REMINERALIZATION AND/OR WHITENING OF TEETH AND KIT FOR ORAL CARE |
CN107157785A (en) * | 2017-05-18 | 2017-09-15 | 中国人民解放军第四军医大学 | A kind of remineralization of teeth toothpaste and preparation method thereof |
CN108542832A (en) * | 2018-07-11 | 2018-09-18 | 佛山皖阳生物科技有限公司 | A kind of antibacterial liquid tooth paste |
US20220061302A1 (en) * | 2019-01-24 | 2022-03-03 | Antwas Aps | Method for eradicating insect nests or animal underground channels |
US11273122B2 (en) * | 2020-02-11 | 2022-03-15 | Therese Mainella | Combination of cannabis, derivatives thereof and additives in oral care compositions |
EP3981376A1 (en) | 2020-10-08 | 2022-04-13 | Universitat Internacional De Catalunya, Fundació Privada | An isoprene-based matrix composition |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3929493A (en) * | 1974-04-09 | 1975-12-30 | Lee Pharmaceuticals | Dental base material |
AU595803B2 (en) * | 1985-06-07 | 1990-04-12 | Cheetham, Jeffrey James | Dental pit and fissure sealant |
JPH0193439A (en) * | 1987-10-02 | 1989-04-12 | Korukooto Kk | Production of crystallized glass for dental material and embedding material |
DE3903407A1 (en) * | 1989-02-06 | 1990-08-09 | Blendax Werke Schneider Co | DENTAL FUELING MATERIAL |
JPH03165773A (en) * | 1989-11-27 | 1991-07-17 | Tdk Corp | Composition for living body and material for living body |
US5074916A (en) * | 1990-05-18 | 1991-12-24 | Geltech, Inc. | Alkali-free bioactive sol-gel compositions |
JPH07112023A (en) * | 1993-10-20 | 1995-05-02 | Matsumoto Shika Univ | Osteogenesis material |
BR9508360A (en) * | 1994-06-06 | 1997-10-28 | Block Drug Co | Composition and method for treating hypersensitive teeth by submicron particles |
US5874101A (en) * | 1997-04-14 | 1999-02-23 | Usbiomaterials Corp. | Bioactive-gel compositions and methods |
-
1999
- 1999-10-18 US US09/419,514 patent/US20020037258A1/en not_active Abandoned
-
2000
- 2000-08-04 EA EA200200115A patent/EA200200115A1/en unknown
- 2000-08-04 KR KR1020027001595A patent/KR20020032546A/en not_active Application Discontinuation
- 2000-08-04 ES ES00951699T patent/ES2296631T3/en not_active Expired - Lifetime
- 2000-08-04 CN CN00813822A patent/CN1377252A/en active Pending
- 2000-08-04 DE DE60037319T patent/DE60037319T2/en not_active Expired - Lifetime
- 2000-08-04 PL PL00364721A patent/PL364721A1/en not_active Application Discontinuation
- 2000-08-04 AT AT00951699T patent/ATE380012T1/en not_active IP Right Cessation
- 2000-08-04 CZ CZ2002438A patent/CZ2002438A3/en unknown
- 2000-08-04 EP EP00951699A patent/EP1202705B1/en not_active Expired - Lifetime
- 2000-08-04 HU HU0203667A patent/HUP0203667A2/en unknown
- 2000-08-04 PT PT00951699T patent/PT1202705E/en unknown
- 2000-08-04 AU AU64557/00A patent/AU6455700A/en not_active Abandoned
- 2000-08-04 WO PCT/GB2000/003015 patent/WO2001010392A2/en active IP Right Grant
- 2000-08-04 BR BR0012971-2A patent/BR0012971A/en not_active IP Right Cessation
- 2000-08-04 JP JP2001514917A patent/JP2003506391A/en active Pending
- 2000-08-04 CA CA2388342A patent/CA2388342C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1202705B1 (en) | 2007-12-05 |
AU6455700A (en) | 2001-03-05 |
KR20020032546A (en) | 2002-05-03 |
JP2003506391A (en) | 2003-02-18 |
CZ2002438A3 (en) | 2002-08-14 |
CN1377252A (en) | 2002-10-30 |
WO2001010392A3 (en) | 2001-07-05 |
WO2001010392A2 (en) | 2001-02-15 |
PT1202705E (en) | 2008-02-25 |
BR0012971A (en) | 2002-04-30 |
ES2296631T3 (en) | 2008-05-01 |
ATE380012T1 (en) | 2007-12-15 |
CA2388342C (en) | 2010-09-14 |
EP1202705A2 (en) | 2002-05-08 |
US20020037258A1 (en) | 2002-03-28 |
PL364721A1 (en) | 2004-12-13 |
EA200200115A1 (en) | 2002-06-27 |
HUP0203667A2 (en) | 2003-04-28 |
DE60037319T2 (en) | 2008-11-27 |
DE60037319D1 (en) | 2008-01-17 |
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