CA2391071C - Multiwell apparatus - Google Patents

Multiwell apparatus Download PDF

Info

Publication number
CA2391071C
CA2391071C CA2391071A CA2391071A CA2391071C CA 2391071 C CA2391071 C CA 2391071C CA 2391071 A CA2391071 A CA 2391071A CA 2391071 A CA2391071 A CA 2391071A CA 2391071 C CA2391071 C CA 2391071C
Authority
CA
Canada
Prior art keywords
lid
channel
negative pressure
multiwell plate
plate body
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2391071A
Other languages
French (fr)
Other versions
CA2391071A1 (en
Inventor
John P. Hall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corning Inc
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of CA2391071A1 publication Critical patent/CA2391071A1/en
Application granted granted Critical
Publication of CA2391071C publication Critical patent/CA2391071C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/523—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for multisample carriers, e.g. used for microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Abstract

A method for assembling a multiwell plate assembly, and a multiwell plate assembly prepared thereby, are provided. The method includes providing a lid for a multiwell plate body having at least one channel being formed therethrough; positioning the lid in proximity to a gasket member; applying sufficient negative pressure to the channel to draw the gasket member towards the lid; positioning the lid above a multiwell plate body, while continuing to apply negative pressure to the channel; emplacing the lid on the multiwell plate body; and, releasing the negative pressure from the channel. Advantageously, as will be recognized by those skilled in the art, various gasket members can be used in conjunction with the subject method, without altering the method. In this manner, gaskets can be selected based on their suitability for use with various biological and/or chemical samples which may be used in the bioassays.

Claims (14)

1. A multiwell plate assembly comprising:

a multiwell plate body having a plurality of wells formed therein; and, a lid formed for emplacement on said multiwell plate body, said lid and said plate body encompassing a volume with said lid being emplaced on said plate body, wherein at least first and second channels are formed through said lid, said channels communicating with said encompassed volume and with an environment external to said lid with said lid being emplaced on said body, wherein a first opening is formed in said lid to communicate with the external environment, said first channel communicating with said first opening and extending through said lid to a second opening communicating with said encompassed volume, said second channel communicating with said first opening and extending through said lid to a third opening communicating with said encompassed volume, said second and third openings being spaced apart.
2. An assembly as in claim 1 further comprising latchable members formed on said lid for latching onto said multiwell plate body.
3. An assembly as in claim 1 further comprising a gasket member disposed in said encompassed volume.
4. An assembly as in claim 3 wherein said gasket member is in at least a partially compressed state being disposed in said encompassed volume.
5. An assembly as in claim 1 wherein said lid includes a top portion, said at least one channel being defined in said top portion, wherein said top portion being shaped convexly downwardly in a natural state.
6. A method of assembling a multiwell plate assembly, said method comprising:
providing a lid having at least one channel being formed therethrough;
positioning said lid in proximity to a gasket member;

applying sufficient negative pressure to said at least one channel to draw said gasket member towards said lid;

positioning said lid above a multiwell plate body having a plurality of wells defined therein, while continuing to apply negative pressure to said at least one channel;
emplacing said lid on said multiwell plate body; and, releasing the negative pressure from said at least one channel.
7. A method as in claim 6 further comprising positioning a vacuum pick apparatus above said lid, said negative pressure being applied to said at least one channel via said vacuum pick apparatus.
8. A method as in claim 7, wherein said vacuum pick apparatus is partitioned into at least first and second zones, negative pressure being generated in said first and second zones being separately controlled, said negative pressure being applied to said at least one channel via said first zone.
9. A method as in claim 8, wherein said lid is formed solid below said second zone.
10. A method as is claim 6, wherein said emplacing includes latching latchable members formed on said lid onto said multiwell plate body.
11. A method as in claim 6, wherein said lid includes a top portion, said at least one channel being defined in said top portion, wherein said top portion being shaped convexly downwardly in a natural state.
12. A method as in claim 6 further comprising applying a negative pressure to said lid.
13. A method as in claim 12, wherein said negative pressure applied to said lid is separately controlled from said negative pressure applied to said at least one channel.
14
CA2391071A 2001-11-19 2002-06-21 Multiwell apparatus Expired - Fee Related CA2391071C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33273501P 2001-11-19 2001-11-19
US60/332,735 2001-11-19
US10/108,640 US7125522B2 (en) 2001-11-19 2002-03-29 Multiwell apparatus
US10/108,640 2002-03-29

Publications (2)

Publication Number Publication Date
CA2391071A1 CA2391071A1 (en) 2003-05-19
CA2391071C true CA2391071C (en) 2010-06-01

Family

ID=26806111

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2391071A Expired - Fee Related CA2391071C (en) 2001-11-19 2002-06-21 Multiwell apparatus

Country Status (5)

Country Link
US (2) US7125522B2 (en)
EP (1) EP1312414A3 (en)
JP (1) JP4233845B2 (en)
AU (2) AU2002301676B2 (en)
CA (1) CA2391071C (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7452712B2 (en) 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
US6970240B2 (en) * 2003-03-10 2005-11-29 Applera Corporation Combination reader
DE10339158A1 (en) * 2003-08-26 2005-04-07 Evotec Technologies Gmbh Handling device for closing elements for sample carriers such as titer plates and micro-titer plates comprises holding body for holding closing element on bearing surface, recess in bearing surface, and suction unit
US20060011305A1 (en) * 2003-09-19 2006-01-19 Donald Sandell Automated seal applicator
US7570443B2 (en) 2003-09-19 2009-08-04 Applied Biosystems, Llc Optical camera alignment
US20050225751A1 (en) * 2003-09-19 2005-10-13 Donald Sandell Two-piece high density plate
US20050226780A1 (en) * 2003-09-19 2005-10-13 Donald Sandell Manual seal applicator
US20060029948A1 (en) * 2003-09-19 2006-02-09 Gary Lim Sealing cover and dye compatibility selection
US20060013984A1 (en) * 2003-09-19 2006-01-19 Donald Sandell Film preparation for seal applicator
US20050226779A1 (en) 2003-09-19 2005-10-13 Oldham Mark F Vacuum assist for a microplate
US7460223B2 (en) * 2003-09-19 2008-12-02 Applied Biosystems Inc. Inverted orientation for a microplate
US20050232818A1 (en) * 2003-09-19 2005-10-20 Donald Sandell Single sheet seal applicator and cartridge
US20050221358A1 (en) * 2003-09-19 2005-10-06 Carrillo Albert L Pressure chamber clamp mechanism
US20050287573A1 (en) * 2004-06-18 2005-12-29 North Dakota State University Lined multi-well plates
EP2046940A4 (en) * 2006-06-26 2011-08-10 Life Technologies Corp Heated cover methods and technology
US20080006202A1 (en) * 2006-06-26 2008-01-10 Applera Corporation Compressible transparent sealing for open microplates
DE202007002538U1 (en) * 2007-02-21 2007-06-06 Krebs, Torsten Device for gasifying biological tissue and bacterial cultures, comprises a single-piece sample reception block exhibiting fluid supply arrangement, and gasifying head for supplying gasifying medium connected with the reception block
CA2724106C (en) * 2009-12-10 2018-04-17 F. Hoffmann-La Roche Ag Multiwell plate and lid
CN103028456B (en) * 2012-08-10 2014-10-08 卢瑾 Detected specimen preserving and processing method and corresponding device
GB2528671B (en) * 2014-07-25 2018-11-14 Rhys Jones Gethin Container handling device
CN107548416B (en) 2015-02-27 2021-07-13 康宁股份有限公司 Compliant cover for multi-well plate
US10227556B2 (en) * 2015-09-04 2019-03-12 Wayne State University Cell culture devices for biomimetic and pathomimetic cell cultures
WO2018144161A1 (en) * 2017-01-31 2018-08-09 Counsyl, Inc. High throughput automatic diagnostic system for removing microplate lids
WO2023141047A1 (en) * 2022-01-20 2023-07-27 Invitae Corporation Device and method for placement and securement of film

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3997404A (en) * 1974-06-07 1976-12-14 Johnston Laboratories, Inc. Method and apparatus for characterizing biologically active agents
US4003713A (en) 1975-08-14 1977-01-18 Bowser Everett N Multiple test tube evaporator
US4657867A (en) * 1984-11-01 1987-04-14 Becton, Dickinson And Company Multiwell tissue culture assembly with features for reduced media evaporation
US4721679A (en) * 1986-10-23 1988-01-26 Yiu Felix H F Tissue typing tray
US5513768A (en) 1992-07-20 1996-05-07 Smith; James C. Sealing cap for containers
US5342581A (en) * 1993-04-19 1994-08-30 Sanadi Ashok R Apparatus for preventing cross-contamination of multi-well test plates
US5961926A (en) * 1993-09-27 1999-10-05 Packard Instrument Co., Inc. Microplate assembly and method of preparing samples for analysis in a microplate assembly
US5897838A (en) 1994-03-11 1999-04-27 Barrskogen, Inc. Apparatus for rapid evaporation of aqueous solutions
AU2122395A (en) * 1994-04-04 1995-10-23 Ashok R. Sanadi Method and apparatus for preventing cross-contamination of multi-well test plates
US5817510A (en) 1995-02-24 1998-10-06 Xechem International, Inc. Device and method for evaluating microorganisms
US5604130A (en) * 1995-05-31 1997-02-18 Chiron Corporation Releasable multiwell plate cover
US5842573A (en) * 1997-03-11 1998-12-01 Halvorsen; Yuan-Di C. Method of transporting cells and kit useful therefor
US5817509A (en) 1997-03-19 1998-10-06 Becton Dickinson And Company Culture vessel assembly
US5851346A (en) * 1997-05-29 1998-12-22 Beckman Instruments, Inc. Apparatus for sealing containers
JP3308209B2 (en) * 1998-05-09 2002-07-29 アトム興産株式会社 Sealing device for multi-well plate
US6436351B1 (en) * 1998-07-15 2002-08-20 Deltagen Research Laboratories, L.L.C. Microtitre chemical reaction system
WO2000013761A1 (en) * 1998-09-04 2000-03-16 Vertex Pharmaceuticals Incorporated Vortex evaporator
WO2000063671A1 (en) * 1999-04-17 2000-10-26 Genevac Limited Evaporation of liquids and recirculation of purified gas
WO2002002405A1 (en) 2000-06-30 2002-01-10 Incyte Genomics, Inc. Microplate sealer
US6939516B2 (en) 2000-09-29 2005-09-06 Becton, Dickinson And Company Multi-well plate cover and assembly adapted for mechanical manipulation
US6896848B1 (en) 2000-12-19 2005-05-24 Tekcel, Inc. Microplate cover assembly
US6450012B1 (en) * 2001-04-30 2002-09-17 Mocon, Inc. Multi-port gas leakage measurement fixture
US6485918B1 (en) * 2001-07-02 2002-11-26 Packard Bioscience Corporation Method and apparatus for incubation of a liquid reagent and target spots on a microarray substrate
JP2003149249A (en) * 2001-08-01 2003-05-21 Becton Dickinson & Co Multiwell plate cover and assembly suitable for mechanical control

Also Published As

Publication number Publication date
US7572411B2 (en) 2009-08-11
EP1312414A3 (en) 2004-03-17
CA2391071A1 (en) 2003-05-19
EP1312414A2 (en) 2003-05-21
US20060280654A1 (en) 2006-12-14
AU2009200345A1 (en) 2009-02-19
JP4233845B2 (en) 2009-03-04
AU2009200345C1 (en) 2011-09-01
AU2009200345B2 (en) 2011-03-10
US20030096427A1 (en) 2003-05-22
AU2002301676B2 (en) 2008-12-11
JP2003227839A (en) 2003-08-15
US7125522B2 (en) 2006-10-24

Similar Documents

Publication Publication Date Title
CA2391071C (en) Multiwell apparatus
CA2321691A1 (en) Method for performing blood cell counts
WO2006041584A3 (en) Breachable seal
WO2002036485A8 (en) Valve integrally associated with microfluidic liquid transport assembly
EP2711415A3 (en) Assay cartridges and methods of using the same
GR3036010T3 (en) A device for performing an assay, a method for manufacturing said device, and use of a membrane in the manufacture of said device
WO2004078350A3 (en) Sample substrate having a divided sample chamber and method of loading thereof
EP1591163A3 (en) Nucleic acid detecting cassette, nucleic acid detecting apparatus utilizing nucleic acid detecting cassette, and nucleic acid detecting system utilizing nucleic acid detecting cassette
WO2002070932A3 (en) Microvalve
DE69524190T2 (en) COMBINED REAGENT RECORDING AND TEST ARRANGEMENT
WO2005072873A3 (en) Diffusion-aided loading system for microfluidic devices
EP1477812A3 (en) Method and apparatus for processing biological and chemical samples
WO2002026384A3 (en) Multi-well assay plate and plate holder and method of assembling the same
TW200609996A (en) Electrowetting cell and method of manufacturing thereof
HK1081479A1 (en) Sampling sevice for liquid samples
WO2002066596A3 (en) Device and method for analyzing ion channels in membranes
WO2004074720A3 (en) Seal ring for pendulum valve assembly
CA2263943A1 (en) Sampler
WO2001053794A8 (en) Parallel sample loading and injection device for multichannel microfluidic devices
DE69413643D1 (en) SAMPLE CARRIER
WO2003022440A3 (en) Holder for multiple well sequencing / pcr plate
KR100601966B1 (en) A microchip unit and a method for conducting a biochemical reaction by using the microchip unit
SE0004574D0 (en) Electrospray interface
MY136188A (en) Method of affixing a pre-formed gasket and gasket used therefor
EP1046833A3 (en) Hydraulic support

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20180621