CA2394155A1 - Process for producing methylcobalamin - Google Patents

Process for producing methylcobalamin Download PDF

Info

Publication number
CA2394155A1
CA2394155A1 CA002394155A CA2394155A CA2394155A1 CA 2394155 A1 CA2394155 A1 CA 2394155A1 CA 002394155 A CA002394155 A CA 002394155A CA 2394155 A CA2394155 A CA 2394155A CA 2394155 A1 CA2394155 A1 CA 2394155A1
Authority
CA
Canada
Prior art keywords
producing methylcobalamin
methylcobalamin
producing
provides
methylating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002394155A
Other languages
French (fr)
Other versions
CA2394155C (en
Inventor
Yoshihiko Hisatake
Hiroshi Kuroda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai Co., Ltd.
Yoshihiko Hisatake
Hiroshi Kuroda
Eisai R&D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co., Ltd., Yoshihiko Hisatake, Hiroshi Kuroda, Eisai R&D Management Co., Ltd. filed Critical Eisai Co., Ltd.
Publication of CA2394155A1 publication Critical patent/CA2394155A1/en
Application granted granted Critical
Publication of CA2394155C publication Critical patent/CA2394155C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention provides an industrially excellent and novel process for producing methylcobalamin useful as medicines. Namely, it provides a process for producing methylcobalamin, which comprises the step of methylating cyanocobalamin or hydroxocobalamin in the presence of a reducing agent and a water-soluble methylating agent.
CA002394155A 1999-12-09 2000-12-07 Process for producing methylcobalamin Expired - Fee Related CA2394155C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP35068399 1999-12-09
JP11/350683 1999-12-09
JP2000188619 2000-06-23
JP2000-188619 2000-06-23
PCT/JP2000/008675 WO2001042271A1 (en) 1999-12-09 2000-12-07 Process for production of methylcobalamin

Publications (2)

Publication Number Publication Date
CA2394155A1 true CA2394155A1 (en) 2001-06-14
CA2394155C CA2394155C (en) 2008-01-15

Family

ID=26579251

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002394155A Expired - Fee Related CA2394155C (en) 1999-12-09 2000-12-07 Process for producing methylcobalamin

Country Status (12)

Country Link
US (1) US6657057B2 (en)
EP (1) EP1236737B1 (en)
JP (1) JP3948958B2 (en)
KR (1) KR100694688B1 (en)
CN (1) CN1170841C (en)
AT (1) ATE318833T1 (en)
CA (1) CA2394155C (en)
DE (1) DE60026354T2 (en)
DK (1) DK1236737T3 (en)
ES (1) ES2257339T3 (en)
TW (1) TW581770B (en)
WO (1) WO2001042271A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220855B2 (en) 2001-06-05 2007-05-22 Eisai Co., Ltd. Process for producing methylcobalamin
CN1720257A (en) * 2002-08-06 2006-01-11 因特拉迪格姆公司 Methods of down regulating target gene expression in vivo by introduction of interfering RNA
ES2264374B1 (en) * 2005-03-23 2007-11-01 Ferrer Internacional, S.A. METHODCOBALAMINE MANUFACTURING PROCEDURE.
CN100348201C (en) * 2005-09-29 2007-11-14 周卓和 Methy cobalamine dispersion tablet and preparing method
JP5779710B2 (en) * 2011-05-30 2015-09-16 インターキム ソシエダッド アノニマ デ キャピタル バリアブレＩｎｔｅｒｑｕｉｍ， Ｓ．Ａ． Ｄｅ Ｃ．Ｖ． Synthesis process of methylcobalamin
CN102391340A (en) * 2011-10-31 2012-03-28 河北玉星生物工程有限公司 Preparation method of mecobalamin
CN105218608A (en) * 2015-10-29 2016-01-06 无锡福祈制药有限公司 A kind of preparation method of mecobalamin
JP6867409B2 (en) 2016-07-08 2021-04-28 ヘルステック バイオ アクティブズ，エス．エル．ユー Method for purifying methylcobalamin
CN106349313B (en) * 2016-08-23 2019-05-14 宁夏泰瑞制药股份有限公司 A method of Mecobalamin crude product is synthesized using cyanocobalamin
CN108546278A (en) * 2018-03-17 2018-09-18 山东辰龙药业有限公司 The process for purification of Mecobalamin
DE102018005078A1 (en) 2018-06-26 2020-01-02 Ilma biochem GmbH Process for the preparation and composition of stabilized cob (II) alamine and cob (II) inamide solutions as starting preparations for the production of medicaments, medical products, food supplements and cosmetics
CN108948116A (en) * 2018-08-30 2018-12-07 上海应用技术大学 A kind of green synthesis process of Mecobalamin
CN111808158B (en) * 2020-07-23 2022-12-06 宁夏金维制药股份有限公司 Preparation method of vitamin B12 crude product
CN114874274A (en) * 2022-04-21 2022-08-09 南京工业大学 Improved method for synthesizing mecobalamin
CN114874276A (en) * 2022-04-21 2022-08-09 南京工业大学 Improved method for synthesizing mecobalamin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4538059B1 (en) * 1967-07-27 1970-12-02
BE759614A (en) * 1969-12-01 1971-06-01 Glaxo Lab Ltd CYANIDE ION REMOVAL FROM CORRINOID SOLUTIONS
GB1306958A (en) * 1970-09-30 1973-02-14 Pierrel Spa Process for the preparation of substituted cobamides
FR2108794B1 (en) 1970-10-06 1974-04-12 Roussel Uclaf
BE789252A (en) * 1971-11-10 1973-03-26 Boige Jean METHOD FOR MANUFACTURING METHYLCOBALAMINE
FR2240232A1 (en) * 1973-08-08 1975-03-07 Boige Jean Methylcobalamine prepn from cyanocobalamine - by reduction and methylation using methyl acid oxalate and a metal
US3928320A (en) * 1971-11-10 1975-12-23 Jean Boige Process for the preparation of methylcobalamine
US3789211A (en) 1972-07-14 1974-01-29 Marvin Glass & Associates Decorative lighting system
JPS4947899A (en) 1972-09-18 1974-05-09
JPS5729587B2 (en) 1973-06-14 1982-06-23
JPS5038120A (en) 1973-08-09 1975-04-09
JPH08143590A (en) * 1994-11-24 1996-06-04 Meiji Seika Kaisha Ltd Production of high-purity methylcobalamin

Also Published As

Publication number Publication date
KR20030022767A (en) 2003-03-17
TW581770B (en) 2004-04-01
US20020183511A1 (en) 2002-12-05
EP1236737A4 (en) 2003-02-26
ES2257339T3 (en) 2006-08-01
DE60026354T2 (en) 2006-11-09
ATE318833T1 (en) 2006-03-15
WO2001042271A1 (en) 2001-06-14
DE60026354D1 (en) 2006-04-27
EP1236737B1 (en) 2006-03-01
KR100694688B1 (en) 2007-03-13
CN1409723A (en) 2003-04-09
US6657057B2 (en) 2003-12-02
CN1170841C (en) 2004-10-13
DK1236737T3 (en) 2006-06-19
JP3948958B2 (en) 2007-07-25
EP1236737A1 (en) 2002-09-04
CA2394155C (en) 2008-01-15

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20121207