CA2395694A1 - Multiple electrospray device, systems and methods - Google Patents

Multiple electrospray device, systems and methods Download PDF

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Publication number
CA2395694A1
CA2395694A1 CA002395694A CA2395694A CA2395694A1 CA 2395694 A1 CA2395694 A1 CA 2395694A1 CA 002395694 A CA002395694 A CA 002395694A CA 2395694 A CA2395694 A CA 2395694A CA 2395694 A1 CA2395694 A1 CA 2395694A1
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Canada
Prior art keywords
electrospray
plumes
disclosed
microchip
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002395694A
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French (fr)
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CA2395694C (en
Inventor
Gary A. Schultz
Thomas N. Corso
Simon J. Prosser
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Advion Inc
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Individual
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Publication of CA2395694A1 publication Critical patent/CA2395694A1/en
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Publication of CA2395694C publication Critical patent/CA2395694C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H01J49/167—Capillaries and nozzles specially adapted therefor
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0013—Miniaturised spectrometers, e.g. having smaller than usual scale, integrated conventional components
    • H01J49/0018—Microminiaturised spectrometers, e.g. chip-integrated devices, MicroElectro-Mechanical Systems [MEMS]
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components

Abstract

A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device (250) includes a substrate (200) defining a channel (224) between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle (232) defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray (262). A method and system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analytes contained within the fluid. A plurality of electrospray nozzle devices (232) can be used in the form of an array of miniaturized nozzles for the purpose of generating multiple electrospray plumes (262) from multiple nozzles (232) for the same fluid stream. This invention dramatically increases the sensitivity of microchip electrospray devices (250) compared to prior disclosed systems and methods.
CA002395694A 1999-12-30 2000-12-22 Multiple electrospray device, systems and methods Expired - Fee Related CA2395694C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17367499P 1999-12-30 1999-12-30
US60/173,674 1999-12-30
PCT/US2000/034999 WO2001050499A1 (en) 1999-12-30 2000-12-22 Multiple electrospray device, systems and methods

Publications (2)

Publication Number Publication Date
CA2395694A1 true CA2395694A1 (en) 2001-07-12
CA2395694C CA2395694C (en) 2006-11-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA002395694A Expired - Fee Related CA2395694C (en) 1999-12-30 2000-12-22 Multiple electrospray device, systems and methods

Country Status (8)

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US (2) US6627882B2 (en)
EP (1) EP1269518B1 (en)
JP (1) JP5057318B2 (en)
CN (1) CN1237572C (en)
AT (1) ATE538490T1 (en)
AU (1) AU2450801A (en)
CA (1) CA2395694C (en)
WO (1) WO2001050499A1 (en)

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AU2450801A (en) 2001-07-16
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US6723985B2 (en) 2004-04-20
EP1269518A1 (en) 2003-01-02
US20030143493A1 (en) 2003-07-31
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WO2001050499A1 (en) 2001-07-12
US6627882B2 (en) 2003-09-30
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JP2003519889A (en) 2003-06-24
US20020000516A1 (en) 2002-01-03

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