CA2398815A1 - Dry powder inhaler - Google Patents

Dry powder inhaler Download PDF

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Publication number
CA2398815A1
CA2398815A1 CA002398815A CA2398815A CA2398815A1 CA 2398815 A1 CA2398815 A1 CA 2398815A1 CA 002398815 A CA002398815 A CA 002398815A CA 2398815 A CA2398815 A CA 2398815A CA 2398815 A1 CA2398815 A1 CA 2398815A1
Authority
CA
Canada
Prior art keywords
chamber
inhaler
bead
inlet
dispersion chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002398815A
Other languages
French (fr)
Other versions
CA2398815C (en
Inventor
Michael Ligotke
Andrew W. Gieschen
Robert F. Eisele
Thomas R. Jackson
Jeffrey Chen
Bernard Greenspan
Clyde Witham
Gary Ward
Charles Ganem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quadrant Technologies Ltd
Original Assignee
Dura Pharmaceuticals, Inc.
Michael Ligotke
Andrew W. Gieschen
Robert F. Eisele
Thomas R. Jackson
Jeffrey Chen
Bernard Greenspan
Clyde Witham
Gary Ward
Charles Ganem
Elan Pharmaceuticals, Inc.
Quadrant Technologies Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dura Pharmaceuticals, Inc., Michael Ligotke, Andrew W. Gieschen, Robert F. Eisele, Thomas R. Jackson, Jeffrey Chen, Bernard Greenspan, Clyde Witham, Gary Ward, Charles Ganem, Elan Pharmaceuticals, Inc., Quadrant Technologies Limited filed Critical Dura Pharmaceuticals, Inc.
Publication of CA2398815A1 publication Critical patent/CA2398815A1/en
Application granted granted Critical
Publication of CA2398815C publication Critical patent/CA2398815C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/0006—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
    • A61M15/0008—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means rotating by airflow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0031—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up by bursting or breaking the package, i.e. without cutting or piercing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0043—Non-destructive separation of the package, e.g. peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/43—General characteristics of the apparatus making noise when used correctly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/18—Coaxial flows, e.g. one flow within another

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

A dry powder inhaler (20) has a dispersion chamber (30) containing beads (40).
A dose of dry powder (142) is released into the chamber, or into an inlet (26) tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece (22), air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from the larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater air flow and powder dispersion, without any increased effort by the patient.

Claims (82)

1. A dry powder inhaler comprising:
a dispersion chamber having an open central area surrounded by a bead race;
a nose/mouthpiece having at least one outlet opening entering into the dispersion chamber;
at least one inlet having at least one inlet opening entering into the dispersion chamber; and at least one bead within the dispersion chamber, with the bead dimensioned so that it can move about in the bead race or in the open central area.
2. The inhaler of claim 1 further comprising a dispersion control device on the at least one inlet.
3. The inhaler of claim 1 further comprising a feedback device for providing feedback to a user of the inhaler, based on inspiratory flow rate.
4. The inhaler of claim 3 wherein the race has a radius of curvature greater than the largest radius of curvature of the smallest bead.
5. The inhaler of claim 1 wherein the dispersion chamber has a flat bottom surface and a flat top surface adjoining the bead race.
6. The inhaler of claim 1 with the at least one bead comprising a material having a density of less than 2 gm/cc
7. The inhaler of claim 1 comprising from 2-10 round beads.
8. The inhaler of claim 1 wherein the at least one bead has a characteristic dimension of from 50-90% of the height of the dispersion chamber.
9. The inhaler of claim 1 wherein the dispersion chamber has a shape selected from the group consisting of round, oval. elliptical, polygonal disk-shaped, bi-concave disk shaped and helical.
10. The inhaler of claim 2 wherein the dispersion control device comprises at least one element selected from the group consisting of a flow delay; a flow limner: a backflow limner; a flow trigger; and a flow adjuster.
11. The inhaler of claim 1 comprising more than 100 beads.
12. The inhaler of claim 1 further comprising a powder loading port on the inlet.
13. The inhaler of claim 1 wherein the at least one bead is disk-shaped, wedge shaped, multi-faceted, a sphere with at least one flat surface, spiked, pie-shaped, ellipsoidal, hollow, or with a through hole.
14. The inhaler of claim 9 wherein the dispersion chamber has a major axis which is perpendicular to the outlet opening (s).
15. The inhaler of the claim 9 wherein the dispersion chamber has a major axis which is parallel to the outlet opening(s).
16. The inhaler of claim 1 wherein the chamber has a characteristic dimension which is from 4-20 times greater than the characteristic dimension of the at least one bead.
17. The inhaler of claim 1 wherein the at least one bead has at least one characteristic selected from the group consisting of: hollow core, solid core, out-of round shape, eccentrically weighted, rough surface, and smooth surface.
18. The inhaler of claim 1 with a plurality of beads in the chamber and wherein each of the beads of the plurality of beads has at least one common characteristic selected from the group consisting of: size, shape, weight; weight distribution;
electrical charge;
electrical polarity; hardness: and surface finish.
19. The inhaler of claim 18 further comprising an obstruction in the dispersion chamber, to induce the beads to move chaotically.
20. The inhaler of claim 1 wherein the inhaler includes a housing, and where the dispersion chamber is removable from the housing
21. The inhaler of claim 1 wherein a plurality of beads are contained in the chamber, and at least one of the beads has a shape which is different from at least one other bead in the chamber.
22. The inhaler of claim 1 further including a powder port on the housing opening directly into the chamber.
23. The inhaler of claim 1 wherein the at least one bead comprises a material having a density greater than 3 gm/cc, and with the density of the bead less than 2 gm/cc.
24. The inhaler of claim 23 wherein the at least one bead is hollow or porous and contains one or more gases.
25. The inhaler of claim 1 wherein the at least one bead comprises more than one material or component, to control weight and surface characteristics such as hardness and smoothness.
26. The inhaler of claim 1 comprising a plurality of beads, with at least one of the beads comprising means for creating chaotic bead motion among the other beads in the chamber.
27. The inhaler of claim 26 wherein the means for creating chaotic bead motion comprises a wedge shaped bead.
28. The inhaler of claim 1 with the dispersion chamber having at least one transparent or translucent area, so that presence of powder in the chamber can be visually confirmed, indicating that a dose of powder has been released into the chamber.
29. The inhaler of claim 1 wherein the dispersion chamber has a flat sidewall section, to control bead motion as flow rate increases.
30. The inhaler of claim 1 with a plurality of beads in the chamber, and wherein at least one of the beads has a characteristic selected from the group consisting of shape, size, weight, weight distribution, density, electrical charge, electrical polarity, hardness and surface finish, which is different from the other beads in the chamber.
31. A dry powder inhaler comprising:
a housing;
a dispersion chamber within the housing;
a nose/mouthpiece having at least one outlet opening connecting into the dispersion chamber;
at least one inlet having at least one inlet opening connecting into the dispersion chamber;
feedback means for providing sound or vibration varying with airflow through the dispersion chamber; and a switch for enabling and disabling the feedback means.
32. A dry powder inhaler comprising:
a dispersion chamber;
a nose/mouthpiece having at least one outlet opening connecting into the dispersion chamber;
at least one inlet having at least one inlet opening connecting into the dispersion chamber;
a bead storage chamber separated from the dispersion chamber by a flow trigger; and at least one bead in the bead storage chamber.
33. The dry powder inhaler of claim 32 wherein the bead storage chamber comprises a tube attached to the dispersion chamber.
34. The inhaler of claim 32 wherein the flow trigger is adapted to open and release the beads from the bead storage chamber, when a threshold level of vacuum or flow is reached.
35. A unit dose drug container for use with a dry powder inhaler. comprising:
a dispersion chamber adapted to fit in the inhaler;
a unit dose of a dry powder drug within the dispersion chamber; and at least one bead within the dispersion chamber.
36. The unit dose drug container of claim 35 wherein the at least one bead has a characteristic dimension of greater than 1 millimeter.
37. The unit dose drug container of claim 36 with the dispersion chamber further comprising an inlet and an outlet, with at least one bead having a size and shape selected so that it cannot pass through the outlet.
38. A method for inhaling a dry powder pharmaceutical comprising the steps of:
drawing air through a chamber in an inhaler;
moving at least one bead in the chamber, so that the bead comes into physical contact with at least some of a dry powder pharmaceutical in the chamber;
separating at least some of the active particles from at least some of the powder particles via contact with the moving bead and airflow;
mixing air in the chamber with at least some of the separated active particles; and moving at least some of the separated active particles and air out of the chamber.
39. The method of claim 38 further comprising the step of moving the at least one bead in a chaotic manner around in the chamber.
40. The method of claim 38 further comprising the step of drawing air tangentially into the mixing chamber from at least one inlet.
41. The method of claim 38 further comprising the step of moving the at least one bead around in the chamber by using a patient's inspiration to entrain the at least one bead in an air flow, so that the at least one bead moves chaotically within the chamber.
42. The method of claim 38 further comprising the step of releasing a dose of powder into the chamber before moving the at least one bead therein.
43. The method of claim 38 further comprising the step of releasing a dose of powder into an inlet connecting into the chamber.
44. The method of claim 38 further comprising the step of entraining a plurality of beads in an air flow within the chamber, and causing the beads to intermittently collide with each other and with the surfaces of the chamber.
45. The method of claim 38 further comprising the step of drawing air through the chamber at first flow rate, thereby causing the at least one bead to move in a uniform manner around the chamber, and drawing the air through the chamber at a second flow rate, greater than the first flow rate, thereby causing the at least one bead to move in a chaotic manner within the chamber.
46. The method of claim 38 wherein the at least one bead has or acquires a static electrical charge, and the dry powder pharmaceutical particles also have or acquire a static electrical charge of the same polarity, so that the at least one bead and the pharmaceutical particles repel each other.
47. The method of claim 38 wherein the chamber is initially free of pharmaceutical powder, further including the step of delivering a dose of powder into the chamber.
48. The method of claim 38 further comprising the step of drawing air through the chamber at first flow rate, thereby causing the at least one bead to move in a uniform manner around the chamber, and transitioning the bead movement from uniform to non-uniform as air flow rate through the chamber increases above the first flow rate, thereby causing the at least one bead to move in a less uniform manner within the chamber.
49. The method of claim 38 further comprising the step of placing the chamber into the inhaler before the drawing air through the chamber step, wherein the chamber is separate, installable into, and removable from the inhaler.
50. The method of claim 48 wherein a plurality of beads are in the chamber, and wherein at least one of the beads includes a discontinuity.
51. The method of claim 50 wherein the beads) with the discontinuity is polygonal shaped, and the discontinuity comprises a corner.
52. The method of claim 50 wherein the at least one bead having the discontinuity comprises a sphere with a flat surface.
53. The method of claim 38 further comprising the step of separating the particles via fluid shear effects caused by flowing air and bead motion.
54. The method of claim 38 further comprising the step of dispersing the particles via scouring and impact of particles within the chamber.
55. A method for providing a dose of a dry powder pharmaceutical to a patient, comprising the steps of:
providing a dose of dry powder in the dispersion chamber of an inhaler;
moving air through the chamber; and reducing the flow resistance of air flow through the dispersion chamber, by providing at least one bead in the dispersion chamber.
56. The method of claim 55 wherein providing the bead in the chamber reduces the flow resistance to a level 15-40% less than the flow resistance of the inhaler without any beads in the chamber.
57. A dry powder inhaler comprising:
a dispersion chamber;
at least one bead in the dispersion chamber;
a mouthpiece connecting into the dispersion chamber via at least one outlet opening; and an inlet having at least one inlet opening connecting into the dispersion chamber, with the inlet not tangent to the dispersion chamber.
58. The inhaler of claim 57 where the inlet is a scoop inlet.
59. The inhaler of claim 57 where the inlet is a chord inlet.
60. The inhaler of claim 57 where the inlet connects into the dispersion chamber at an angle.
61. The inhaler of claim 57 further including an elongated exit tube extending from the dispersion chamber into the mouthpiece.
62. The inhaler of claim 57 with the dispersion chamber having a top wall and a bottom wall, and further including a chamber ring on the top wall, surrounding the outlet, and projecting towards the bottom wall, to prevent the at least one bead from moving into the outlet.
63. The inhaler of claim 57 with the dispersion chamber having a top wall and a bottom wall, and further including a central land area extending from bottom wall towards the top wall, and substantially aligned below the outlet, to prevent the at least one bead from moving into the outlet.
64. A dry powder inhaler comprising:
a dispersion chamber having walls forming a bead race;
at least one bead in the dispersion chamber;
a mouthpiece with at least one outlet opening connecting into the dispersion chamber; and a chord inlet having at least one inlet opening connecting into the dispersion chamber, with the inlet intersecting the bead race along a chord of the dispersion chamber, and with the chord inlet not tangent to the bead race.
65. A dry powder inhaler comprising:
a dispersion chamber containing a bead race having an outer wall;
at least one bead in the dispersion chamber;
a mouthpiece with at least one outlet opening connecting into the dispersion chamber; and an inlet having at least one inlet opening connecting into the dispersion chamber, with the inlet having an outer inlet wall positioned to the outside of a line tangent to the bead race.
66. An inhaler, comprising:
a mouthpiece tube having an inlet end and an outlet end;
a dispersion chamber connecting into the inlet end of the mouthpiece tube;
and at least one sheath air inlet extending into the mouthpiece tube adjacent to the inlet end.
67. The inhaler of claim 66 further comprising a plurality of radially spaced apart sheath air inlets into the mouthpiece adjacent to the inlet end of the mouthpiece tube.
68. The inhaler of claim 66 further comprising a ring extending into the inlet end of the mouthpiece tube at the at least one sheath air inlet.
69. The inhaler of claim 66 further comprising an elongated exit tube extending from the dispersion chamber into the inlet end of the mouthpiece tube.
70. The inhaler of claim 66 where the sheath air inlets extend between the inlet end of the mouthpiece tube and the dispersion chamber.
71. The inhaler of claim 67 where the plurality of sheath air inlets are equally radially spaced apart.
72. The inhaler of claim 69 where the exit tube and the inner walls of the mouthpiece tube form a sheath air region for axial flow of sheath air through the mouthpiece tube, to reduce deposition of particles within the inhaler.
73. The inhaler of claim 66 wherein the exit tube is asymmetrically positioned relative to the inner walls of the mouthpiece tube.
74. The inhaler of claim 66 where the mouthpiece tube comprises a hollow cylinder.
75. The inhaler of claim 66 wherein the mouthpiece tube comprises an expanding cone.
76. A method for delivering a dose of a pharmaceutical, comprising the steps of:
dispersing the pharmaceutical within a chamber, in air or a gas to form an aerosol;~
drawing the aerosol out of the chamber and into a mouthpiece tube;
drawing sheath air into the mouthpiece tube, around the aerosol, to limit contact between the aerosol and the inner walls of the mouthpiece tube.
77. The method of claim 76 where the sheath air enters into the mouthpiece tube in a direction not parallel to the axis of the mouthpiece tube and then turns so that the sheath air flows in a direction parallel to the axis of the mouthpiece tube.
78. The method of claim 76 where the sheath air and the aerosol move at substantially the same speed.
79. A dry powder inhaler comprising:
a dispersion chamber;
at least one bead in the dispersion chamber, a mouthpiece connecting into the dispersion chamber via at least one outlet opening;
an inlet having at least one inlet opening connecting into the dispersion chamber; and a guide associated with the inlet opening for guiding air flow from the inlet into the chamber.
80. The inhaler of claim 57 where the outlet opening is centered with the dispersion chamber.
81. The inhaler of claim 57 where the inlet has a cross section shape selected from the group consisting of round, oval, elliptical, and equilateral quadrilateral with radiuses corners.
82. The inhaler of claim 70 where the sheath air region has a cross section area which varies due to at least one of the inside walls of the mouthpiece tube and the outside of the exit tube having a non round shape.
CA2398815A 2000-02-01 2001-01-31 Dry powder inhaler Expired - Fee Related CA2398815C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/495,494 US6427688B1 (en) 2000-02-01 2000-02-01 Dry powder inhaler
US09/495,494 2000-02-01
PCT/US2001/003248 WO2001056640A1 (en) 2000-02-01 2001-01-31 Dry powder inhaler

Publications (2)

Publication Number Publication Date
CA2398815A1 true CA2398815A1 (en) 2001-08-09
CA2398815C CA2398815C (en) 2012-04-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2398815A Expired - Fee Related CA2398815C (en) 2000-02-01 2001-01-31 Dry powder inhaler

Country Status (7)

Country Link
US (5) US6427688B1 (en)
EP (1) EP1307256B1 (en)
JP (1) JP4886143B2 (en)
AU (1) AU2001233201A1 (en)
CA (1) CA2398815C (en)
ES (1) ES2432353T3 (en)
WO (1) WO2001056640A1 (en)

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