CA2400319A1 - Coating that promotes endothelial cell adherence - Google Patents

Coating that promotes endothelial cell adherence Download PDF

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Publication number
CA2400319A1
CA2400319A1 CA002400319A CA2400319A CA2400319A1 CA 2400319 A1 CA2400319 A1 CA 2400319A1 CA 002400319 A CA002400319 A CA 002400319A CA 2400319 A CA2400319 A CA 2400319A CA 2400319 A1 CA2400319 A1 CA 2400319A1
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CA
Canada
Prior art keywords
matrix
medical device
antibodies
coating
endothelial cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002400319A
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French (fr)
Other versions
CA2400319C (en
Inventor
Robert John Cottone Jr.
Stephen Maxwell Rowland
Michael John Bradley Kutryk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orbusneich Medical Pte Ltd
Original Assignee
Orbus Medical Technologies Inc.
Robert John Cottone Jr.
Stephen Maxwell Rowland
Michael John Bradley Kutryk
Orbusneich Medical, Inc.
Orbusneich Medical Pte. Ltd.
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Application filed by Orbus Medical Technologies Inc., Robert John Cottone Jr., Stephen Maxwell Rowland, Michael John Bradley Kutryk, Orbusneich Medical, Inc., Orbusneich Medical Pte. Ltd. filed Critical Orbus Medical Technologies Inc.
Publication of CA2400319A1 publication Critical patent/CA2400319A1/en
Application granted granted Critical
Publication of CA2400319C publication Critical patent/CA2400319C/en
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    • C12N2510/00—Genetically modified cells

Abstract

This invention provides compositions and methods for producing a medical device such as a stent or a synthetic graft, coated with a matrix and an antibody which reacts with an endothelial cell antigen. The matrix coating the medical device may be composed of synthetic material, such as polyurethane, poly-L-lactic acid, cellulose ester or polyethylene glycol. In another embodiment, the matrix is composed of naturally occurring materials, such as collagen, fibrin, elastin, amorphous carbon. In a third embodiment, the matrix may be composed of fullerenes which range from about C60 to about C100.
The antibodies promote adherence of endothedial cells on the medical device. The antibodies may be mixed with the matrix or covalently tethered through a linker molecule to the matrix. Following adherence to the medical device, the endothelial cells differentiate and proliferate on the medical device. The antibodies may be different types of monoclonal antibodies.
CA002400319A 2000-03-15 2001-03-15 Coating that promotes endothelial cell adherence Expired - Lifetime CA2400319C (en)

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US18967400P 2000-03-15 2000-03-15
US60/189,674 2000-03-15
US20178900P 2000-05-04 2000-05-04
US60/201,789 2000-05-04
PCT/US2001/008244 WO2001068158A1 (en) 2000-03-15 2001-03-15 Coating that promotes endothelial cell adherence

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CA2400319A1 true CA2400319A1 (en) 2001-09-20
CA2400319C CA2400319C (en) 2008-09-16

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AU (1) AU2001245734A1 (en)
CA (1) CA2400319C (en)
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ES (1) ES2283398T3 (en)
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