CA2400416A1 - System and method for intravascular radiation therapy - Google Patents
System and method for intravascular radiation therapy Download PDFInfo
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- CA2400416A1 CA2400416A1 CA002400416A CA2400416A CA2400416A1 CA 2400416 A1 CA2400416 A1 CA 2400416A1 CA 002400416 A CA002400416 A CA 002400416A CA 2400416 A CA2400416 A CA 2400416A CA 2400416 A1 CA2400416 A1 CA 2400416A1
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- 238000001959 radiotherapy Methods 0.000 title claims abstract description 11
- 238000000034 method Methods 0.000 title claims description 13
- 230000005855 radiation Effects 0.000 claims abstract description 46
- 230000002285 radioactive effect Effects 0.000 claims abstract description 44
- 239000003550 marker Substances 0.000 claims abstract description 29
- 230000005865 ionizing radiation Effects 0.000 claims abstract description 18
- 210000005166 vasculature Anatomy 0.000 claims description 13
- 230000000694 effects Effects 0.000 description 5
- 210000001624 hip Anatomy 0.000 description 5
- 230000002792 vascular Effects 0.000 description 5
- 238000002594 fluoroscopy Methods 0.000 description 3
- 238000002399 angioplasty Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 208000037803 restenosis Diseases 0.000 description 2
- 206010057469 Vascular stenosis Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004980 dosimetry Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1002—Intraluminal radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
- A61M25/0108—Steering means as part of the catheter or advancing means; Markers for positioning using radio-opaque or ultrasound markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1011—Multiple balloon catheters
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
A system for intravascular ionizing radiation therapy including a radiation device and a guide wire having radiopaque markers to facilitate precise repositioning of the radiation source along the length of the treatment site.
The radiopaque markers are separated by a distance L, which corresponds to the distance between the 50 % dose points in the dose fall-off regions. This produces partial dose overlap when the radioactive source is positioned in tandem adjacent each radiopaque marker. Preferably, only the dose fall-off regions overlap thereby providing more uniform and complete radiation exposure along the length of the treatment site.
The radiopaque markers are separated by a distance L, which corresponds to the distance between the 50 % dose points in the dose fall-off regions. This produces partial dose overlap when the radioactive source is positioned in tandem adjacent each radiopaque marker. Preferably, only the dose fall-off regions overlap thereby providing more uniform and complete radiation exposure along the length of the treatment site.
Description
SYSTEM AND METHOD FOR INTRAVASCULAR RADIATION THERAPY
Field of the Invention The present invention generally relates to medical devices. More specifically, the present invention relates to medical devices suitable for intravascular ionizing radiation therapy.
Background of the Invention l0 Intravascular ionizing radiation therapy is being used increasingly to treat vascular disease. For example, the administration of ionizing radiation has been proposed as both a primary and a secondary therapy for treating vascular stenosis (a vascular restriction or narrowing). Clinical studies have shown that ionizing radiation may be used to inhibit or prevent restenosis after percutaneous transluminal angioplasty (PTA). In coronary applications, such vascular restrictions may range in length from a few millimeters to several centimeters, depending on the extent and nature of the disease, in addition to the size and type of vessel affected.
Typically, physicians evaluate the size and nature of the vascular restriction in order to determine the appropriate treatment parameters (e.g., radiation source length, dose, etc.). Radiation devices commonly utilize a fixed-length ionizing radiation source, and only a limited number of different lengths are available. In some instances, the physician is not able to select a source length that matches the length of the treatment site. In this situation, the physician may elect to use a relatively short radiation source and reposition the source in tandem along the length of the treatment site until the entire site has been exposed to the desired amount of radiation.
However, unless the radiation source is precisely repositioned, various areas of the treatment site will inevitably receive more or less radiation exposure than other areas of the treatment site. Precise repositioning of the radiation source is difficult, if not impossible, due to image foreshortening, even when anatomical landmarks are used as reference points. Thus, there is a need for a more precise method of repositioning the radiation source along the length of the treatment site.
Summary of the Invention The present invention overcomes these disadvantages by providing a system for intravascular ionizing radiation therapy including a radiation device and a guide wire, wherein the guide wire includes radiopaque markers that facilitate precise repositioning of the radiation device. The radiopaque markers are separated by a distance L, which is equal to the distance between points in the dose fall-off regions (edge effects) corresponding to 50% of the nominal dose. This produces partial dose overlap when the radioactive source is sequentially positioned adjacent each radiopaque marker. Preferably, only the dose fall off regions (edge effects) overlap 1 o thereby providing more uniform and complete radiation exposure along the length of the treatment site.
The radiation device may include a centering catheter and a source wire, wherein the source wire is insertable into the centering catheter. The radioactive source is disposed adjacent the distal end of the source wire. The centering catheter ~ 5 preferably includes a guide wire lumen with the guide wire slidably disposed therein.
The centering catheter and/or the source wire may include radiopaque markers for alignment with the radiopaque markers on the guide wire.
The radiation source may be a line source having a dosimetry or dose distribution with a nominal dose, a proximal dose fall-off and a distal dose fall-off.
20 The distance L is preferably about equal to the distance between a point in the proximal dose fall-off and a point in the distal dose fall-off. The proximal and distal points preferably correspond to points on the dose distribution equal to half of the nominal dose such that the total dose at the overlap is approximately equal to the nominal dose.
25 The present invention also provides a method of administering ionizing radiation at a treatment site within a patient's vasculature. The method includes the steps of: providing a radiation device and a guide wire substantially as described above; navigating the guide wire through the vasculature of the patient until the markers on the guide wire are disposed adjacent the treatment site; inserting the 3o radiation device into the vasculature of the patient over or adjacent to the guide wire;
positioning the radioactive source adjacent a marker on the guide wire; and repositioning (in the proximal or distal direction) the radioactive source adjacent the neighboring marker on the guide wire such that slight dose overlap is created thereby providing more uniform and complete radiation exposure along the length of the treatment site.
Brief Description of the Drawings Fig. 1 is a partially cross-sectioned side view of a system for intravascular ionizing radiation therapy in accordance with the present invention;
Fig. 2 is a side view of the guide wire used in the system illustrated in Fig.
1;
Fig. 3 is a cross-sectional side view of the source wire used in the system illustrated in Fig. 1;
Fig. 4 is a cross-sectional side view of the centering catheter used in the system illustrated in Fig. 1;
Figs. 5A and SB are side views of the radiation source wire disposed in the vasculature illustrating the dose overlap aspect of the present invention; and Figs. 6A and 6B are partially cross-sectioned side views illustrating a method of administering ionizing radiation using the system illustrated in Fig. 1.
Detailed Description of the Invention The following detailed description should be read with reference to the drawings in which similar elements in different drawings are numbered the same.
2o The drawings, which are merely schematic and not necessarily to scale, depict illustrative embodiments and are not intended to limit the scope of the invention.
Refer now to Figure 1 which illustrates a system 10 for intravascular ionizing radiation therapy in accordance with the present invention. System 10 includes two primary components, namely a guide wire 12 and a radiation device 14.
Radiation device 14 may include two separate components, namely a source wire 16 and a centering catheter 18 as shown. However, radiation device 14 may comprise any suitable intravascular device or combination of intravascular devices having a radioactive portion disposed adjacent the distal end thereof. For purposes of illustration only, the radiation device 14 is shown as a source wire I6 and a centering 3o catheter 18. More detailed descriptions of the guide wire 12, the source wire 16, and the centering catheter 18 are provided with reference to Figures 2, 3 and 4, respectively.
Field of the Invention The present invention generally relates to medical devices. More specifically, the present invention relates to medical devices suitable for intravascular ionizing radiation therapy.
Background of the Invention l0 Intravascular ionizing radiation therapy is being used increasingly to treat vascular disease. For example, the administration of ionizing radiation has been proposed as both a primary and a secondary therapy for treating vascular stenosis (a vascular restriction or narrowing). Clinical studies have shown that ionizing radiation may be used to inhibit or prevent restenosis after percutaneous transluminal angioplasty (PTA). In coronary applications, such vascular restrictions may range in length from a few millimeters to several centimeters, depending on the extent and nature of the disease, in addition to the size and type of vessel affected.
Typically, physicians evaluate the size and nature of the vascular restriction in order to determine the appropriate treatment parameters (e.g., radiation source length, dose, etc.). Radiation devices commonly utilize a fixed-length ionizing radiation source, and only a limited number of different lengths are available. In some instances, the physician is not able to select a source length that matches the length of the treatment site. In this situation, the physician may elect to use a relatively short radiation source and reposition the source in tandem along the length of the treatment site until the entire site has been exposed to the desired amount of radiation.
However, unless the radiation source is precisely repositioned, various areas of the treatment site will inevitably receive more or less radiation exposure than other areas of the treatment site. Precise repositioning of the radiation source is difficult, if not impossible, due to image foreshortening, even when anatomical landmarks are used as reference points. Thus, there is a need for a more precise method of repositioning the radiation source along the length of the treatment site.
Summary of the Invention The present invention overcomes these disadvantages by providing a system for intravascular ionizing radiation therapy including a radiation device and a guide wire, wherein the guide wire includes radiopaque markers that facilitate precise repositioning of the radiation device. The radiopaque markers are separated by a distance L, which is equal to the distance between points in the dose fall-off regions (edge effects) corresponding to 50% of the nominal dose. This produces partial dose overlap when the radioactive source is sequentially positioned adjacent each radiopaque marker. Preferably, only the dose fall off regions (edge effects) overlap 1 o thereby providing more uniform and complete radiation exposure along the length of the treatment site.
The radiation device may include a centering catheter and a source wire, wherein the source wire is insertable into the centering catheter. The radioactive source is disposed adjacent the distal end of the source wire. The centering catheter ~ 5 preferably includes a guide wire lumen with the guide wire slidably disposed therein.
The centering catheter and/or the source wire may include radiopaque markers for alignment with the radiopaque markers on the guide wire.
The radiation source may be a line source having a dosimetry or dose distribution with a nominal dose, a proximal dose fall-off and a distal dose fall-off.
20 The distance L is preferably about equal to the distance between a point in the proximal dose fall-off and a point in the distal dose fall-off. The proximal and distal points preferably correspond to points on the dose distribution equal to half of the nominal dose such that the total dose at the overlap is approximately equal to the nominal dose.
25 The present invention also provides a method of administering ionizing radiation at a treatment site within a patient's vasculature. The method includes the steps of: providing a radiation device and a guide wire substantially as described above; navigating the guide wire through the vasculature of the patient until the markers on the guide wire are disposed adjacent the treatment site; inserting the 3o radiation device into the vasculature of the patient over or adjacent to the guide wire;
positioning the radioactive source adjacent a marker on the guide wire; and repositioning (in the proximal or distal direction) the radioactive source adjacent the neighboring marker on the guide wire such that slight dose overlap is created thereby providing more uniform and complete radiation exposure along the length of the treatment site.
Brief Description of the Drawings Fig. 1 is a partially cross-sectioned side view of a system for intravascular ionizing radiation therapy in accordance with the present invention;
Fig. 2 is a side view of the guide wire used in the system illustrated in Fig.
1;
Fig. 3 is a cross-sectional side view of the source wire used in the system illustrated in Fig. 1;
Fig. 4 is a cross-sectional side view of the centering catheter used in the system illustrated in Fig. 1;
Figs. 5A and SB are side views of the radiation source wire disposed in the vasculature illustrating the dose overlap aspect of the present invention; and Figs. 6A and 6B are partially cross-sectioned side views illustrating a method of administering ionizing radiation using the system illustrated in Fig. 1.
Detailed Description of the Invention The following detailed description should be read with reference to the drawings in which similar elements in different drawings are numbered the same.
2o The drawings, which are merely schematic and not necessarily to scale, depict illustrative embodiments and are not intended to limit the scope of the invention.
Refer now to Figure 1 which illustrates a system 10 for intravascular ionizing radiation therapy in accordance with the present invention. System 10 includes two primary components, namely a guide wire 12 and a radiation device 14.
Radiation device 14 may include two separate components, namely a source wire 16 and a centering catheter 18 as shown. However, radiation device 14 may comprise any suitable intravascular device or combination of intravascular devices having a radioactive portion disposed adjacent the distal end thereof. For purposes of illustration only, the radiation device 14 is shown as a source wire I6 and a centering 3o catheter 18. More detailed descriptions of the guide wire 12, the source wire 16, and the centering catheter 18 are provided with reference to Figures 2, 3 and 4, respectively.
Refer now to Figure 2 which illustrates the guide wire 12 utilized in the system 10 illustrated in Figure 1. With the exception of the placement and use of the radiopaque markers 24 and 26, the guide wire 12 may have a conventional design incorporating an elongate shaft 20 and an atraumatic distal tip 22. A pair of radiopaque markers 24 and 26 are disposed adjacent the distal portion of the guide wire 12. Radiopaque markers 24 and 26 may comprise conventional radiopaque marker designs such as coils or bands formed of radiopaque material and disposed about the elongate shaft 20.
The proximal radiopaque marker 24 is separated by a distance L from the to distal radiopaque marker 26. The distance L is selected to provide partial dose overlap as will be discussed in greater detail with reference to Figures SA
and SB.
Although guide wire 12 is shown as having only two radiopaque markers 24 and 26, two or more radiopaque markers may be utilized, depending on the length of the treatment site and the length of the radioactive source as will be appreciated from the I s discussion with reference to Figures 6A and 6B.
Refer now to Figure 3 which illustrates the radiation source wire 16 utilized in the system 10 illustrated in Figure 1. Elongate source wire 16 includes two primary components, namely an elongate shaft 30 and a distally disposed radioactive source 32. Radioactive source 32 may approximate a line source as illustrated. The radiation 20 source 32 includes a radioisotope emitting ionizing radiation such as beta or gamma radiation. Preferably, the radioactive source 32 comprises a radiation emitting isotope such as Sr/Y-90, P-32, Y-90, Ce/Pr-144, Ru/Rh-106, W/Re-188, Ir-192, I-125, or Pd-103. Radiopaque markers 34 and 36 may be disposed on either side of the radioactive source 32 to facilitate intravascular placement utilizing x-ray fluoroscopy.
Elongate 25 source wire 16 may comprise a wide variety of different designs incorporating an elongate shaft 30 and a distally disposed radioactive source 32. Preferably, the source wire 16 comprises the design disclosed in U.S. Patent No. 5,728,042 to Schwager, which is hereby incorporated by reference.
Refer now to Figure 4 which illustrates the centering catheter 18 utilized in the 3o system 10 illustrated in Figure 1. Catheter 18 may comprise a wide variety of centering and non-centering catheter designs such as those disclosed in European Patent Application Publication No. 0 688 580 Al to Verin et al., European Patent Application Publication No. 0 633 041 Al to Popowski et al., International Patent _4_ Application Publication No. WO 96/14898 to Bradshaw et al., U.S. Patent No.
5,855,546 to Hastings et al., and U.S. Patent No. 5,910,101 to Andrews et al., which are hereby incorporated by reference. For purposes of illustration only, centering catheter 18 is illustrated as comprising the design of Figure 3 in European Patent Application Publication No. 0 688 580 A1 to Verin et al.
Centering catheter 18 includes an elongate shaft 40 and a distally mounted balloon 42. The elongate shaft 40 includes an inflation lumen 44 to define a fluid path connecting the interior of the balloon to a proximally connected inflation device (not shown). The elongate shaft 40 also includes a source lumen 46 which is sized 1 o and adapted to receive the radioactive source wire 16 illustrated in Figure 3. The distal end of the elongate shaft 40 includes a guide wire lumen 48 which is sized and adapted to receive the guide wire 12 illustrated in Figure 2.
The balloon 42 includes a proximal waist 43, a distal waist 45, and a plurality of middle waists 47. The middle waists 47 may be defined by a belt 41 or may be ~ 5 molded into the balloon 42 during the manufacture thereof. Belt 41 may comprise a coil or band of polymeric or metallic material, preferably a radiopaque material. By providing a plurality of middle waists 47, the balloon 42 is able to easily conform to a curve to thereby maintain the source lumen 46 in the center of the vessel despite curvature thereof. By maintaining the source lumen 46 in the axial center of a vessel, 2o the radioactive source 32 delivers a uniform dosage to the vascular wall.
Refer now to Figures SA and SB which illustrate the radiation source wire 16 disposed in the vasculature 50. Figure SA shows the radioactive source 32 in a first position, and Figure SB illustrates the radioactive source in a second position displaced from the first position by a distance L in the direction of arrow 52. The 25 distance L illustrated in Figure SB corresponds to the distance L between the radiopaque markers 24 and 26 disposed on the guide wire 12 as shown in Figure 2.
In the embodiment illustrated, the radioactive source 32 comprises a line source having a generally elliptical (uniform center with tapered ends) dose line 54.
Due to the elliptical dose line 54, only a portion of the dose length 56 provides a full 3o dose 58 to the vessel wall 50. The remainder of the dose length 56 provides a partial dose to the vessel wall 50 in the proximal dose fall-off (edge effect) region 60 and the distal dose fall-off (edge effect) region 62. Because vessel wall 50 corresponding to the proximal and distal dose fall-off regions 60 and 62 only receives part of the nominal or full dose, the present invention provides a means for overlapping the dose fall-off regions to provide a full dose in the overlap region 64 as illustrated in Figure SB.
This is accomplished by displacing the radioactive source 32 a distance L in the direction indicated by arrow 52 wherein the length L is equal to the distance between a proximal point 66 in the proximal dose fall-off region 60 and a distal point 68 in the distal dose fall-off region 62. The proximal point 66 and the distal point 68 preferably correspond to points on the dose line 54 equal to half (SO%) of the nominal or full dose such that the total dose in the overlap region 64 is approximately equal to t o the nominal dose. By displacing the center line 70 (or other reference point) of the radioactive source 32 the distance L, the full dose region 58 (including overlap region 64) is distributed over substantially the entire treatment length.
Refer now to Figures 6A and 6B which illustrate a method of administering ionizing radiation to a vessel wall using the system 10 illustrated in Figure 1. For purposes of illustration and clarity only, the vessel walls are not shown in Figures 6A
and 6B. It is to understood, however, that the system 10 is designed for use in the vascular system of a patient for purposes of administering ionizing radiation to inhibit or reduce the effects of restenosis. This method requires the use of elongate radiation device 14 and guide wire 16. As mentioned previously, the radiation device 14 may 2o comprise any intravascular device having a distally disposed radioactive source. For purposes of illustration only, the method of the present invention is described with reference to a radiation device 14 that includes a centering catheter 18 and a source wire 16.
Initially, the guide wire 12 is inserted into the vasculature of the patient such that the proximal and distal radiopaque markers 24 and 36 are disposed adjacent the treatment site. As mentioned previously, more than two radiopaque markers 24 and 26 may be utilized, depending on the length of the treatment site and the length of the radiation source 32. For example, if a relatively short radiation source is utilized to treat a relatively long treatment site, it may be necessary to provide three, four, five or more radiopaque markers on the guide wire 12. Each of the radiopaque markers would be disposed on the distal portion of the guide wire 12 and separated by a distance L. The repositioning steps described below would be repeated for each radiopaque marker.
After the guide wire is positioned within the vasculature such that the radiopaque markers 24 and 26 are adjacent the treatment site, the radiation device 14 may be advanced over the guide wire 12 or alongside the guide wire 12, depending on whether or not the radiation device 14 incorporated a guide wire lumen. If the radiation device 14 includes a source wire 16 and a centering catheter 18, the centering catheter 18 may be advanced prior to advancing the source wire 16.
The centering catheter 18 may be advanced manually in a conventional manner with the assistance of x-ray fluoroscopy, and the source wire 16 may be advanced into the centering catheter manually or utilizing an afterloader.
The radiation device 14 is advanced through the vasculature until the radiation source 32 is disposed adjacent to, and in alignment with, the radiopaque distal marker 26. This may be accomplished by centering the proximal and distal radiopaque markers 34 and 36 of the source wire 16 on either side of the proximal marker 24 of the guide wire 12. Alternatively, the center belt 41 may be aligned with the radiopaque marker 24 of the guide wire 12, and the radiopaque markers 34 and 36 of the source wire 16 may be aligned with the center belt 41. Regardless of the method, x-ray fluoroscopy is utilized to effectively align the center line 70 of the radioactive source 32 with the distal marker 26. Those skilled in the art will recognize that other suitable reference lines and arrangements of radiopaque markers may be utilized to 2o accomplish the same result.
After exposing the treatment site with the radioactive source 32 positioned adjacent to the distal marker 26 for the desired period of time, the radioactive device 14 is displaced in the direction indicated by arrow 52 the distance L such that the center line 70 of the radioactive source 32 is in alignment with the proximal marker 24. By so positioning the radioactive source 32, dose overlap is created as discussed with reference to Figures 5A and 5B. After the desired period of time, the radiation device 14 may be withdrawn, or displaced in the direction indicated by arrow 52 the distance L such that the radiation source 32 is adjacent yet another radiopaque marker (not shown) disposed on the guide wire 12. Those skilled in the art will recognize 3o that the radioactive source 32 may be repositioned in the proximal direction as described, or in the distal direction if desired.
From the foregoing, it should be apparent to those skilled in the art that the present invention provides a system 10 for intravascular ionizing radiation therapy including a radiation device 14 and a guide wire 12. The guide wire 12 incorporates two or more radiopaque markers 24 and 26 to facilitate precise repositioning of the radiation source 32 along the length of the treatment site. The radiopaque markers 24 and 26 are separated by a distance L, which may be different than (e.g., slightly less than) the length of the radioactive source 32. This produces partial dose overlap 64 when the radioactive source is positioned sequentially adjacent each radiopaque marker 24 and 26 on the guide wire 12. This provides more uniform and complete radiation exposure along the length of the treatment site.
Those skilled in the art will recognize that the present invention may be 1 o manifested in a variety of forms other than the specific embodiments described and contemplated herein. Accordingly, departures in form and detail may be made without departing from the scope and spirit of the present invention as described in the appended claims.
_g_
The proximal radiopaque marker 24 is separated by a distance L from the to distal radiopaque marker 26. The distance L is selected to provide partial dose overlap as will be discussed in greater detail with reference to Figures SA
and SB.
Although guide wire 12 is shown as having only two radiopaque markers 24 and 26, two or more radiopaque markers may be utilized, depending on the length of the treatment site and the length of the radioactive source as will be appreciated from the I s discussion with reference to Figures 6A and 6B.
Refer now to Figure 3 which illustrates the radiation source wire 16 utilized in the system 10 illustrated in Figure 1. Elongate source wire 16 includes two primary components, namely an elongate shaft 30 and a distally disposed radioactive source 32. Radioactive source 32 may approximate a line source as illustrated. The radiation 20 source 32 includes a radioisotope emitting ionizing radiation such as beta or gamma radiation. Preferably, the radioactive source 32 comprises a radiation emitting isotope such as Sr/Y-90, P-32, Y-90, Ce/Pr-144, Ru/Rh-106, W/Re-188, Ir-192, I-125, or Pd-103. Radiopaque markers 34 and 36 may be disposed on either side of the radioactive source 32 to facilitate intravascular placement utilizing x-ray fluoroscopy.
Elongate 25 source wire 16 may comprise a wide variety of different designs incorporating an elongate shaft 30 and a distally disposed radioactive source 32. Preferably, the source wire 16 comprises the design disclosed in U.S. Patent No. 5,728,042 to Schwager, which is hereby incorporated by reference.
Refer now to Figure 4 which illustrates the centering catheter 18 utilized in the 3o system 10 illustrated in Figure 1. Catheter 18 may comprise a wide variety of centering and non-centering catheter designs such as those disclosed in European Patent Application Publication No. 0 688 580 Al to Verin et al., European Patent Application Publication No. 0 633 041 Al to Popowski et al., International Patent _4_ Application Publication No. WO 96/14898 to Bradshaw et al., U.S. Patent No.
5,855,546 to Hastings et al., and U.S. Patent No. 5,910,101 to Andrews et al., which are hereby incorporated by reference. For purposes of illustration only, centering catheter 18 is illustrated as comprising the design of Figure 3 in European Patent Application Publication No. 0 688 580 A1 to Verin et al.
Centering catheter 18 includes an elongate shaft 40 and a distally mounted balloon 42. The elongate shaft 40 includes an inflation lumen 44 to define a fluid path connecting the interior of the balloon to a proximally connected inflation device (not shown). The elongate shaft 40 also includes a source lumen 46 which is sized 1 o and adapted to receive the radioactive source wire 16 illustrated in Figure 3. The distal end of the elongate shaft 40 includes a guide wire lumen 48 which is sized and adapted to receive the guide wire 12 illustrated in Figure 2.
The balloon 42 includes a proximal waist 43, a distal waist 45, and a plurality of middle waists 47. The middle waists 47 may be defined by a belt 41 or may be ~ 5 molded into the balloon 42 during the manufacture thereof. Belt 41 may comprise a coil or band of polymeric or metallic material, preferably a radiopaque material. By providing a plurality of middle waists 47, the balloon 42 is able to easily conform to a curve to thereby maintain the source lumen 46 in the center of the vessel despite curvature thereof. By maintaining the source lumen 46 in the axial center of a vessel, 2o the radioactive source 32 delivers a uniform dosage to the vascular wall.
Refer now to Figures SA and SB which illustrate the radiation source wire 16 disposed in the vasculature 50. Figure SA shows the radioactive source 32 in a first position, and Figure SB illustrates the radioactive source in a second position displaced from the first position by a distance L in the direction of arrow 52. The 25 distance L illustrated in Figure SB corresponds to the distance L between the radiopaque markers 24 and 26 disposed on the guide wire 12 as shown in Figure 2.
In the embodiment illustrated, the radioactive source 32 comprises a line source having a generally elliptical (uniform center with tapered ends) dose line 54.
Due to the elliptical dose line 54, only a portion of the dose length 56 provides a full 3o dose 58 to the vessel wall 50. The remainder of the dose length 56 provides a partial dose to the vessel wall 50 in the proximal dose fall-off (edge effect) region 60 and the distal dose fall-off (edge effect) region 62. Because vessel wall 50 corresponding to the proximal and distal dose fall-off regions 60 and 62 only receives part of the nominal or full dose, the present invention provides a means for overlapping the dose fall-off regions to provide a full dose in the overlap region 64 as illustrated in Figure SB.
This is accomplished by displacing the radioactive source 32 a distance L in the direction indicated by arrow 52 wherein the length L is equal to the distance between a proximal point 66 in the proximal dose fall-off region 60 and a distal point 68 in the distal dose fall-off region 62. The proximal point 66 and the distal point 68 preferably correspond to points on the dose line 54 equal to half (SO%) of the nominal or full dose such that the total dose in the overlap region 64 is approximately equal to t o the nominal dose. By displacing the center line 70 (or other reference point) of the radioactive source 32 the distance L, the full dose region 58 (including overlap region 64) is distributed over substantially the entire treatment length.
Refer now to Figures 6A and 6B which illustrate a method of administering ionizing radiation to a vessel wall using the system 10 illustrated in Figure 1. For purposes of illustration and clarity only, the vessel walls are not shown in Figures 6A
and 6B. It is to understood, however, that the system 10 is designed for use in the vascular system of a patient for purposes of administering ionizing radiation to inhibit or reduce the effects of restenosis. This method requires the use of elongate radiation device 14 and guide wire 16. As mentioned previously, the radiation device 14 may 2o comprise any intravascular device having a distally disposed radioactive source. For purposes of illustration only, the method of the present invention is described with reference to a radiation device 14 that includes a centering catheter 18 and a source wire 16.
Initially, the guide wire 12 is inserted into the vasculature of the patient such that the proximal and distal radiopaque markers 24 and 36 are disposed adjacent the treatment site. As mentioned previously, more than two radiopaque markers 24 and 26 may be utilized, depending on the length of the treatment site and the length of the radiation source 32. For example, if a relatively short radiation source is utilized to treat a relatively long treatment site, it may be necessary to provide three, four, five or more radiopaque markers on the guide wire 12. Each of the radiopaque markers would be disposed on the distal portion of the guide wire 12 and separated by a distance L. The repositioning steps described below would be repeated for each radiopaque marker.
After the guide wire is positioned within the vasculature such that the radiopaque markers 24 and 26 are adjacent the treatment site, the radiation device 14 may be advanced over the guide wire 12 or alongside the guide wire 12, depending on whether or not the radiation device 14 incorporated a guide wire lumen. If the radiation device 14 includes a source wire 16 and a centering catheter 18, the centering catheter 18 may be advanced prior to advancing the source wire 16.
The centering catheter 18 may be advanced manually in a conventional manner with the assistance of x-ray fluoroscopy, and the source wire 16 may be advanced into the centering catheter manually or utilizing an afterloader.
The radiation device 14 is advanced through the vasculature until the radiation source 32 is disposed adjacent to, and in alignment with, the radiopaque distal marker 26. This may be accomplished by centering the proximal and distal radiopaque markers 34 and 36 of the source wire 16 on either side of the proximal marker 24 of the guide wire 12. Alternatively, the center belt 41 may be aligned with the radiopaque marker 24 of the guide wire 12, and the radiopaque markers 34 and 36 of the source wire 16 may be aligned with the center belt 41. Regardless of the method, x-ray fluoroscopy is utilized to effectively align the center line 70 of the radioactive source 32 with the distal marker 26. Those skilled in the art will recognize that other suitable reference lines and arrangements of radiopaque markers may be utilized to 2o accomplish the same result.
After exposing the treatment site with the radioactive source 32 positioned adjacent to the distal marker 26 for the desired period of time, the radioactive device 14 is displaced in the direction indicated by arrow 52 the distance L such that the center line 70 of the radioactive source 32 is in alignment with the proximal marker 24. By so positioning the radioactive source 32, dose overlap is created as discussed with reference to Figures 5A and 5B. After the desired period of time, the radiation device 14 may be withdrawn, or displaced in the direction indicated by arrow 52 the distance L such that the radiation source 32 is adjacent yet another radiopaque marker (not shown) disposed on the guide wire 12. Those skilled in the art will recognize 3o that the radioactive source 32 may be repositioned in the proximal direction as described, or in the distal direction if desired.
From the foregoing, it should be apparent to those skilled in the art that the present invention provides a system 10 for intravascular ionizing radiation therapy including a radiation device 14 and a guide wire 12. The guide wire 12 incorporates two or more radiopaque markers 24 and 26 to facilitate precise repositioning of the radiation source 32 along the length of the treatment site. The radiopaque markers 24 and 26 are separated by a distance L, which may be different than (e.g., slightly less than) the length of the radioactive source 32. This produces partial dose overlap 64 when the radioactive source is positioned sequentially adjacent each radiopaque marker 24 and 26 on the guide wire 12. This provides more uniform and complete radiation exposure along the length of the treatment site.
Those skilled in the art will recognize that the present invention may be 1 o manifested in a variety of forms other than the specific embodiments described and contemplated herein. Accordingly, departures in form and detail may be made without departing from the scope and spirit of the present invention as described in the appended claims.
_g_
Claims (17)
1. A medical system for intravascular ionizing radiation therapy, comprising:
an elongate radiation device having a radiopaque marker and a radioactive source disposed adjacent a distal end thereof, the radioactive source having a length and a dose distribution, the dose distribution having a nominal dose, a proximal dose fall-off, a distal dose fall-off, a proximal point in the proximal dose fall-off corresponding to 50% of the nominal dose, a distal point in the distal dose fall-off corresponding to 50% of the nominal dose, wherein the proximal 50% point is separated from the distal 50% point by a distance L; and an elongate guide wire having a plurality of radiopaque markers disposed adjacent a distal region thereof, the radiopaque markers separated by the distance L
such that dose fall-off overlap is created when the radioactive source is positioned adjacent each radiopaque marker.
an elongate radiation device having a radiopaque marker and a radioactive source disposed adjacent a distal end thereof, the radioactive source having a length and a dose distribution, the dose distribution having a nominal dose, a proximal dose fall-off, a distal dose fall-off, a proximal point in the proximal dose fall-off corresponding to 50% of the nominal dose, a distal point in the distal dose fall-off corresponding to 50% of the nominal dose, wherein the proximal 50% point is separated from the distal 50% point by a distance L; and an elongate guide wire having a plurality of radiopaque markers disposed adjacent a distal region thereof, the radiopaque markers separated by the distance L
such that dose fall-off overlap is created when the radioactive source is positioned adjacent each radiopaque marker.
2. A medical system as in claim 1, wherein the distance L is less than the length of the radioactive source.
3. A medical system as in claim 1, wherein the radioactive source is a line source.
4. A medical system as in claim 1, wherein the elongate radiation device includes a delivery catheter and a source wire insertable therein, the radioactive source disposed adjacent a distal end of the source wire.
5. A medical system as in claim 4, wherein the delivery catheter includes a guide wire lumen, and wherein the guide wire is disposed in the guide wire lumen.
6. A medical system as in claim 5, wherein the delivery catheter includes a centering means disposed adjacent a distal end thereof.
7. A medical system as in claim 6, wherein the delivery catheter includes a radiopaque marker disposed adjacent the centering means.
8. A medical system as in claim 7, wherein the centering means has a proximal end, a distal end and a midpoint therebetween, and wherein the radiopaque marker is disposed adjacent the midpoint of the centering means.
9. A medical system as in claim 7, wherein the centering means has a proximal end, a distal end and a midpoint therebetween, and wherein the radiopaque marker is disposed adjacent the proximal end of the centering means.
10. A medical system as in claim 7, wherein the centering means has a proximal end, a distal end and a midpoint therebetween, and wherein the radiopaque marker is disposed adjacent the distal end of the centering means.
11. A medical system as in claim 10, wherein the delivery catheter includes a first and second radiopaque marker, the first radiopaque marker disposed adjacent the proximal end of the centering means and the second radiopaque marker disposed adjacent the distal end of the centering means.
12. A medical system as in claim 10, wherein the source wire includes a radiopaque marker disposed adjacent the radioactive source.
13. A guide wire for use in combination with an elongate radiation device for intravascular ionizing radiation therapy, wherein the elongate radiation device includes a radioactive source disposed adjacent a distal end thereof, the radioactive source having a length and a dose distribution, the dose distribution having a nominal dose, a proximal dose fall-off, a distal dose fall-off, a proximal point in the proximal dose fall-off corresponding to 50% of the nominal dose, a distal point in the distal dose fall-off corresponding to 50% of the nominal dose, wherein the proximal 50%
point is separated from the distal 50% point by a distance L, the guide wire comprising:
an elongate shaft having a distal region; and two or more radiopaque markers disposed adjacent the distal region of the shaft, the radiopaque markers separated by the distance L such that dose fall-off overlap is created when the radioactive source is positioned adjacent each radiopaque marker.
point is separated from the distal 50% point by a distance L, the guide wire comprising:
an elongate shaft having a distal region; and two or more radiopaque markers disposed adjacent the distal region of the shaft, the radiopaque markers separated by the distance L such that dose fall-off overlap is created when the radioactive source is positioned adjacent each radiopaque marker.
14. A guide wire as in claim 13, wherein the distance L is less than the length of the radioactive source
15. A method of administering ionizing radiation at a treatment site within a patient's vasculature, comprising the steps of:
providing an elongate radiation device having a radiopaque marker and a radioactive source disposed adjacent a distal end thereof, the radioactive source having a length and a dose distribution, the dose distribution having a nominal dose, a proximal dose fall-off, a distal dose fall-off, a proximal point in the proximal dose fall-off corresponding to 50% of the nominal dose, a distal point in the distal dose fall-off corresponding to 50% of the nominal dose, wherein the proximal 50%
point is separated from the distal 50% point by a distance L;
providing an elongate guide wire having a proximal and a distal radiopaque marker disposed adjacent a distal region thereof, the radiopaque markers separated by the distance L;
inserting the guide wire into the vasculature of the patient;
advancing the guide wire through the vasculature until the radiopaque markers are disposed adjacent the treatment site;
inserting the radiation device into the vasculature of the patient;
positioning the radioactive source adjacent one of the radiopaque markers; and repositioning the radioactive source adjacent the other of the radiopaque markers such that dose fall-off overlap is created.
providing an elongate radiation device having a radiopaque marker and a radioactive source disposed adjacent a distal end thereof, the radioactive source having a length and a dose distribution, the dose distribution having a nominal dose, a proximal dose fall-off, a distal dose fall-off, a proximal point in the proximal dose fall-off corresponding to 50% of the nominal dose, a distal point in the distal dose fall-off corresponding to 50% of the nominal dose, wherein the proximal 50%
point is separated from the distal 50% point by a distance L;
providing an elongate guide wire having a proximal and a distal radiopaque marker disposed adjacent a distal region thereof, the radiopaque markers separated by the distance L;
inserting the guide wire into the vasculature of the patient;
advancing the guide wire through the vasculature until the radiopaque markers are disposed adjacent the treatment site;
inserting the radiation device into the vasculature of the patient;
positioning the radioactive source adjacent one of the radiopaque markers; and repositioning the radioactive source adjacent the other of the radiopaque markers such that dose fall-off overlap is created.
16. A method as in claim 15, wherein the radiation device is inserted into the vasculature over the guide wire.
17. A method as in claim 15, wherein the distance L is less than the length of the radioactive source.
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US09/522,122 US6416457B1 (en) | 2000-03-09 | 2000-03-09 | System and method for intravascular ionizing tandem radiation therapy |
US09/522,122 | 2000-03-09 | ||
PCT/US2001/002888 WO2001066188A1 (en) | 2000-03-09 | 2001-01-29 | System and method for intravascular radiation therapy |
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CA2400416A1 true CA2400416A1 (en) | 2001-09-13 |
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CA002400416A Abandoned CA2400416A1 (en) | 2000-03-09 | 2001-01-29 | System and method for intravascular radiation therapy |
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Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4538918B2 (en) * | 2000-08-02 | 2010-09-08 | 株式会社カネカ | Medical catheter for treating part of a body tube with ionizing radiation |
US6471671B1 (en) | 2000-08-23 | 2002-10-29 | Scimed Life Systems, Inc. | Preloaded gas inflation device for balloon catheter |
US6875165B2 (en) * | 2001-02-22 | 2005-04-05 | Retinalabs, Inc. | Method of radiation delivery to the eye |
US6749555B1 (en) * | 2003-02-13 | 2004-06-15 | Proxima Therapeutics, Inc. | System and method for the treatment of spinal metastases |
BRPI0507690A (en) | 2004-02-12 | 2007-07-24 | Neovista Inc | methods and apparatus for intraocular brachytherapy |
US7662082B2 (en) | 2004-11-05 | 2010-02-16 | Theragenics Corporation | Expandable brachytherapy device |
WO2007059208A2 (en) | 2005-11-15 | 2007-05-24 | Neovista Inc. | Methods and apparatus for intraocular brachytherapy |
US7465268B2 (en) | 2005-11-18 | 2008-12-16 | Senorx, Inc. | Methods for asymmetrical irradiation of a body cavity |
SE0502594L (en) * | 2005-11-28 | 2007-05-29 | Micropos Medical Ab | A device for measuring administered dose in a target range |
ATE514457T1 (en) * | 2006-10-08 | 2011-07-15 | Cianna Medical Inc | EXPANDABLE BRACHYTHERAPY DEVICE |
US8328711B2 (en) | 2007-12-18 | 2012-12-11 | Cytyc Corporation | Selectable multi-lumen brachytherapy devices and methods |
AU2009256236A1 (en) | 2008-06-04 | 2009-12-10 | Neovista, Inc. | Handheld radiation delivery system for advancing a radiation source wire |
US9579524B2 (en) | 2009-02-11 | 2017-02-28 | Hologic, Inc. | Flexible multi-lumen brachytherapy device |
US9248311B2 (en) * | 2009-02-11 | 2016-02-02 | Hologic, Inc. | System and method for modifying a flexibility of a brachythereapy catheter |
US10207126B2 (en) * | 2009-05-11 | 2019-02-19 | Cytyc Corporation | Lumen visualization and identification system for multi-lumen balloon catheter |
US8382650B2 (en) * | 2009-05-11 | 2013-02-26 | Cytyc Corporation | Catheter marking for multi-lumen catheter identification |
US8221349B2 (en) * | 2009-10-29 | 2012-07-17 | Kyphon Sarl | Anterior inflation balloon |
US8262609B2 (en) * | 2009-10-29 | 2012-09-11 | Kyphon Sarl | Anterior inflation balloon |
US9352172B2 (en) | 2010-09-30 | 2016-05-31 | Hologic, Inc. | Using a guide member to facilitate brachytherapy device swap |
US10342992B2 (en) | 2011-01-06 | 2019-07-09 | Hologic, Inc. | Orienting a brachytherapy applicator |
US8961525B2 (en) | 2011-01-28 | 2015-02-24 | Kyphon Sarl | Inflatable bone tamp with predetermined extensibility |
EP3527250B8 (en) * | 2012-12-31 | 2020-11-04 | Clearstream Technologies Limited | Radiopaque balloon catheter and guidewire to facilitate alignment |
US9295510B2 (en) | 2013-02-06 | 2016-03-29 | Kyphon SÀRL | Device for performing a surgical procedure and methods of use |
EP3125971A4 (en) | 2014-04-02 | 2018-10-24 | GC Medtech LLC | Internal body cavity therapeutic applicators and methods for using them |
US10231770B2 (en) | 2015-01-09 | 2019-03-19 | Medtronic Holding Company Sárl | Tumor ablation system |
US10265111B2 (en) | 2016-04-26 | 2019-04-23 | Medtronic Holding Company Sárl | Inflatable bone tamp with flow control and methods of use |
JP6803402B2 (en) * | 2016-06-17 | 2020-12-23 | 貝克生医股▲フン▼有限公司BRAXX Biotech Co., Ltd. | Conduit device and proximity irradiation treatment system |
US11484355B2 (en) * | 2020-03-02 | 2022-11-01 | Medtronic Holding Company Sàrl | Inflatable bone tamp and method for use of inflatable bone tamp |
Family Cites Families (206)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2546761A (en) | 1950-01-13 | 1951-03-27 | Radium Chemical Company Inc | Radium nasopharyngeal applicator |
GB725067A (en) | 1952-07-02 | 1955-03-02 | Asea Ab | A device for containing and exposing a radioactive material |
US2955208A (en) | 1955-05-10 | 1960-10-04 | Technical Operations Inc | Radiographic device |
US3060924A (en) | 1960-06-01 | 1962-10-30 | Joseph C Rush | Apparatus for application of radioactive substance to pelvic cancer |
US3147383A (en) | 1962-05-16 | 1964-09-01 | Technical Operations Inc | Apparatus for manipulating radioactive material to and from a storage chamber |
US3324847A (en) | 1964-06-01 | 1967-06-13 | Elias G Zoumboulis | Radioactive catheter |
US3505991A (en) | 1968-02-13 | 1970-04-14 | Us Air Force | Intracorporeal vascular prosthetic blood irradiator |
SE318971B (en) | 1968-05-02 | 1969-12-22 | Atomenergi Ab | |
US3643096A (en) | 1969-02-27 | 1972-02-15 | Gen Nuclear Inc | Radioactive source shield with safe position indicator |
FR2033653A5 (en) | 1969-02-28 | 1970-12-04 | Commissariat Energie Atomique | |
DE1945015A1 (en) | 1969-09-05 | 1971-03-11 | Kurt Dr Sauerwein | Device for medical treatment with radiation from radioactive substances |
US3750653A (en) | 1970-09-08 | 1973-08-07 | School Of Medicine University | Irradiators for treating the body |
CA980022A (en) | 1972-05-15 | 1975-12-16 | Douglas Whitfield | Remotely controlled brachytherapy unit |
US3811426A (en) | 1973-05-21 | 1974-05-21 | Atomic Energy Commission | Method and apparatus for the in-vessel radiation treatment of blood |
US3927325A (en) | 1974-07-10 | 1975-12-16 | Us Energy | Tissue irradiator |
US4096862A (en) | 1976-05-17 | 1978-06-27 | Deluca Salvatore A | Locating of tubes in the human body |
DE2727359C2 (en) | 1977-06-16 | 1986-02-20 | Sauerwein, Kurt, Dr., 5657 Haan | Radiography machine with radiator capsule |
US4588395A (en) | 1978-03-10 | 1986-05-13 | Lemelson Jerome H | Catheter and method |
US4225790A (en) | 1978-11-27 | 1980-09-30 | Technical Operations, Incorporated | Storage reel assembly |
US4281252A (en) | 1978-11-27 | 1981-07-28 | Technical Operations, Inc. | Coupling apparatus for portable radiography systems |
US4244357A (en) | 1979-01-05 | 1981-01-13 | Morrison Richard A | Method and apparatus for homogeneously irradiating the vaginal mucosa with a linear source uterovaginal applicator |
US4314157A (en) | 1979-06-21 | 1982-02-02 | Industrial Nuclear Company, Inc. | Safety lock for radiography exposure device |
US4364376A (en) | 1979-12-26 | 1982-12-21 | Bigham Keith E | Method and device for injecting a bolus of material into a body |
DE3335438C2 (en) | 1983-09-30 | 1985-09-05 | Sauerwein, Kurt, Dr., 5657 Haan | Radiation treatment device |
US4584991A (en) | 1983-12-15 | 1986-04-29 | Tokita Kenneth M | Medical device for applying therapeutic radiation |
EP0165993A1 (en) | 1983-12-27 | 1986-01-02 | The Board Of Trustees Of The Leland Stanford Junior University | Catheter for treatment of tumors and method for using same |
US4697575A (en) | 1984-11-21 | 1987-10-06 | Henry Ford Hospital | Delivery system for interstitial radiation therapy including substantially non-deflecting elongated member |
DE3442762A1 (en) | 1984-11-23 | 1986-06-26 | Anwer Dipl.-Ing. 8520 Erlangen Puthawala | REMOTE CONTROLLED AFTERLOADING DEVICE FOR BRACHYCURIE THERAPY OF TUMORS |
US4702228A (en) | 1985-01-24 | 1987-10-27 | Theragenics Corporation | X-ray-emitting interstitial implants |
US5141487A (en) | 1985-09-20 | 1992-08-25 | Liprie Sam F | Attachment of radioactive source and guidewire in a branchy therapy source wire |
US4706652A (en) | 1985-12-30 | 1987-11-17 | Henry Ford Hospital | Temporary radiation therapy |
US4763642A (en) | 1986-04-07 | 1988-08-16 | Horowitz Bruce S | Intracavitational brachytherapy |
NL8601808A (en) | 1986-07-10 | 1988-02-01 | Hooft Eric T | METHOD FOR TREATING A BODY PART WITH RADIOACTIVE MATERIAL AND CART USED THEREIN |
US4819618A (en) | 1986-08-18 | 1989-04-11 | Liprie Sam F | Iridium/platinum implant, method of encapsulation, and method of implantation |
US4976266A (en) | 1986-08-29 | 1990-12-11 | United States Department Of Energy | Methods of in vivo radiation measurement |
US4782834A (en) | 1987-01-06 | 1988-11-08 | Advanced Cardiovascular Systems, Inc. | Dual lumen dilatation catheter and method of manufacturing the same |
FR2609898B1 (en) | 1987-01-28 | 1989-03-31 | Commissariat Energie Atomique | DEVICE FOR DRIVING AND POSITIONING A SOURCE HOLDER IN AN APPLICATOR USED IN CURIETHERAPY |
JPS6446056U (en) | 1987-09-17 | 1989-03-22 | ||
US4936823A (en) | 1988-05-04 | 1990-06-26 | Triangle Research And Development Corp. | Transendoscopic implant capsule |
US5242437A (en) | 1988-06-10 | 1993-09-07 | Trimedyne Laser Systems, Inc. | Medical device applying localized high intensity light and heat, particularly for destruction of the endometrium |
US4994013A (en) | 1988-07-28 | 1991-02-19 | Best Industries, Inc. | Pellet for a radioactive seed |
US5084002A (en) | 1988-08-04 | 1992-01-28 | Omnitron International, Inc. | Ultra-thin high dose iridium source for remote afterloader |
US5183455A (en) | 1988-10-07 | 1993-02-02 | Omnitron International, Inc. | Apparatus for in situ radiotherapy |
US5103395A (en) | 1988-10-07 | 1992-04-07 | Spako David W | System for remote positioning of a radioactive source into a patient including means for protection against improper patient exposure to radiation |
US4976680A (en) | 1988-10-07 | 1990-12-11 | Hayman Michael H | Apparatus for in situ radiotherapy |
US4861520A (en) | 1988-10-28 | 1989-08-29 | Eric van't Hooft | Capsule for radioactive source |
US4969863A (en) | 1988-10-28 | 1990-11-13 | Eric van't Hooft | Adaptor for remote after-loading apparatus for radiotherapy |
US5032113A (en) | 1989-04-13 | 1991-07-16 | Scimed Life Systems, Inc. | Innerless catheter |
US4963128A (en) | 1989-03-21 | 1990-10-16 | University Of Virginia Alumni Patents Foundation | Chest tube and catheter grid for intrathoracic afterload radiotherapy |
US5147282A (en) | 1989-05-04 | 1992-09-15 | William Kan | Irradiation loading apparatus |
US4976690A (en) | 1989-08-10 | 1990-12-11 | Scimed Life Systems, Inc. | Variable stiffness angioplasty catheter |
US5176617A (en) | 1989-12-11 | 1993-01-05 | Medical Innovative Technologies R & D Limited Partnership | Use of a stent with the capability to inhibit malignant growth in a vessel such as a biliary duct |
US5059166A (en) | 1989-12-11 | 1991-10-22 | Medical Innovative Technologies R & D Limited Partnership | Intra-arterial stent with the capability to inhibit intimal hyperplasia |
US5209730A (en) | 1989-12-19 | 1993-05-11 | Scimed Life Systems, Inc. | Method for placement of a balloon dilatation catheter across a stenosis and apparatus therefor |
US5199939B1 (en) | 1990-02-23 | 1998-08-18 | Michael D Dake | Radioactive catheter |
US5267960A (en) | 1990-03-19 | 1993-12-07 | Omnitron International Inc. | Tissue engaging catheter for a radioactive source wire |
US5213561A (en) | 1990-09-06 | 1993-05-25 | Weinstein Joseph S | Method and devices for preventing restenosis after angioplasty |
DE9017649U1 (en) | 1990-09-08 | 1991-06-20 | Isotopen-Technik Dr. Sauerwein Gmbh, 5657 Haan, De | |
US5053033A (en) | 1990-10-10 | 1991-10-01 | Boston Advanced Technologies, Inc. | Inhibition of restenosis by ultraviolet radiation |
US5092834A (en) | 1990-10-12 | 1992-03-03 | Omnitron International, Inc. | Apparatus and method for the remote handling of highly radioactive sources in the treatment of cancer |
US5282781A (en) | 1990-10-25 | 1994-02-01 | Omnitron International Inc. | Source wire for localized radiation treatment of tumors |
US5484384A (en) | 1991-01-29 | 1996-01-16 | Med Institute, Inc. | Minimally invasive medical device for providing a radiation treatment |
US5354257A (en) | 1991-01-29 | 1994-10-11 | Med Institute, Inc. | Minimally invasive medical device for providing a radiation treatment |
JPH0564660A (en) | 1991-05-21 | 1993-03-19 | Sumitomo Bakelite Co Ltd | Medical catheter and making thereof |
US5395300A (en) | 1991-06-07 | 1995-03-07 | Omnitron International, Inc. | High dosage radioactive source |
US5429582A (en) | 1991-06-14 | 1995-07-04 | Williams; Jeffery A. | Tumor treatment |
US5370685A (en) | 1991-07-16 | 1994-12-06 | Stanford Surgical Technologies, Inc. | Endovascular aortic valve replacement |
CN1026755C (en) | 1991-08-17 | 1994-11-30 | 王力平 | Internal radiotherapy and apparatus thereof |
US5302168A (en) | 1991-09-05 | 1994-04-12 | Hess Robert L | Method and apparatus for restenosis treatment |
US5391139A (en) | 1992-09-03 | 1995-02-21 | William Beaumont Hospital | Real time radiation treatment planning system |
US5425720A (en) | 1993-01-27 | 1995-06-20 | Rogalsky; Alena | Medical needle unit |
US5405309A (en) | 1993-04-28 | 1995-04-11 | Theragenics Corporation | X-ray emitting interstitial implants |
US5643171A (en) | 1993-05-04 | 1997-07-01 | Neocardia, Llc | Method and apparatus for uniform radiation treatment of vascular lumens |
JPH09501326A (en) | 1993-05-04 | 1997-02-10 | オムニトロン インターナショナル インコーポレイテッド | Radiation source wire, device using the same, and treatment method |
DE4315002C1 (en) | 1993-05-06 | 1994-08-18 | Kernforschungsz Karlsruhe | Vascular implant |
US5409015A (en) | 1993-05-11 | 1995-04-25 | Target Therapeutics, Inc. | Deformable tip super elastic guidewire |
DE69326455T2 (en) | 1993-07-01 | 2000-01-20 | Schneider Europ Gmbh Buelach | Medicinal devices for the treatment of blood vessels by means of ionization radiation |
US5540659A (en) | 1993-07-15 | 1996-07-30 | Teirstein; Paul S. | Irradiation catheter and method of use |
US5498227A (en) | 1993-09-15 | 1996-03-12 | Mawad; Michel E. | Retrievable, shielded radiotherapy implant |
US5532122A (en) | 1993-10-12 | 1996-07-02 | Biotraces, Inc. | Quantitation of gamma and x-ray emitting isotopes |
US5707332A (en) | 1994-01-21 | 1998-01-13 | The Trustees Of Columbia University In The City Of New York | Apparatus and method to reduce restenosis after arterial intervention |
US6217503B1 (en) | 1994-01-21 | 2001-04-17 | The Trustees Of Columbia University In The City Of New York | Apparatus and method to treat a disease process in a luminal structure |
US5503613A (en) | 1994-01-21 | 1996-04-02 | The Trustees Of Columbia University In The City Of New York | Apparatus and method to reduce restenosis after arterial intervention |
US5538494A (en) | 1994-03-17 | 1996-07-23 | Hitachi, Ltd. | Radioactive beam irradiation method and apparatus taking movement of the irradiation area into consideration |
US5618266A (en) | 1994-03-31 | 1997-04-08 | Liprie; Samuel F. | Catheter for maneuvering radioactive source wire to site of treatment |
US5556389A (en) | 1994-03-31 | 1996-09-17 | Liprie; Samuel F. | Method and apparatus for treating stenosis or other constriction in a bodily conduit |
US5840064A (en) | 1994-03-31 | 1998-11-24 | United States Surgical Corporation | Method and apparatus for treating stenosis or other constriction in a bodily conduit |
US5503614A (en) | 1994-06-08 | 1996-04-02 | Liprie; Samuel F. | Flexible source wire for radiation treatment of diseases |
US5857956A (en) | 1994-06-08 | 1999-01-12 | United States Surgical Corporation | Flexible source wire for localized internal irradiation of tissue |
DE69413209T2 (en) | 1994-06-10 | 1999-03-04 | Schneider Europ Gmbh | Medicinal device for the treatment of a part of body vessels by means of ionizing radiation |
EP0965363B1 (en) | 1994-06-24 | 2002-02-13 | Schneider (Europe) GmbH | Medical appliance for the treatment of a portion of body vessel by ionizing radiation |
US5899882A (en) | 1994-10-27 | 1999-05-04 | Novoste Corporation | Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient |
US5683345A (en) | 1994-10-27 | 1997-11-04 | Novoste Corporation | Method and apparatus for treating a desired area in the vascular system of a patient |
US5616114A (en) | 1994-12-08 | 1997-04-01 | Neocardia, Llc. | Intravascular radiotherapy employing a liquid-suspended source |
US6059752A (en) | 1994-12-09 | 2000-05-09 | Segal; Jerome | Mechanical apparatus and method for dilating and irradiating a site of treatment |
EP0805703B1 (en) | 1995-01-17 | 1999-07-28 | Christoph Hehrlein | Balloon catheter used to prevent re-stenosis after angioplasty and process for producing a balloon catheter |
US5653683A (en) | 1995-02-28 | 1997-08-05 | D'andrea; Mark A. | Intracavitary catheter for use in therapeutic radiation procedures |
US5605530A (en) | 1995-03-23 | 1997-02-25 | Fischell; Robert E. | System for safe implantation of radioisotope stents |
US5851172A (en) | 1995-05-08 | 1998-12-22 | Omnitron International, Inc. | Afterloader with active force feedback |
US5730698A (en) | 1995-05-09 | 1998-03-24 | Fischell; Robert E. | Balloon expandable temporary radioisotope stent system |
ATE192346T1 (en) | 1995-06-22 | 2000-05-15 | Schneider Europ Gmbh | MEDICINAL DEVICE FOR THE TREATMENT OF A PART OF A BODY VESSEL USING IONIZATION RADIATION |
DE19526690A1 (en) | 1995-07-21 | 1997-01-23 | Huels Chemische Werke Ag | Process for the production of a flexible fixation material with catheters or tubes for radiotherapy |
DE19526680A1 (en) | 1995-07-21 | 1997-01-23 | Huels Chemische Werke Ag | Flexible, adaptable plastic body with single catheters or equidistantly embedded catheters or sleeves for the introduction of catheters for radiation therapy |
US5947958A (en) | 1995-09-14 | 1999-09-07 | Conceptus, Inc. | Radiation-transmitting sheath and methods for its use |
US5836892A (en) | 1995-10-30 | 1998-11-17 | Cordis Corporation | Guidewire with radiopaque markers |
US5833593A (en) | 1995-11-09 | 1998-11-10 | United States Surgical Corporation | Flexible source wire for localized internal irradiation of tissue |
US5840008A (en) | 1995-11-13 | 1998-11-24 | Localmed, Inc. | Radiation emitting sleeve catheter and methods |
US5713828A (en) | 1995-11-27 | 1998-02-03 | International Brachytherapy S.A | Hollow-tube brachytherapy device |
DE69530302T2 (en) | 1995-12-05 | 2004-01-29 | Schneider Europ Gmbh Buelach | A filament for irradiating a living body and a method for producing a filament for irradiating a living body |
US5840009A (en) | 1995-12-05 | 1998-11-24 | Isostent, Inc. | Radioisotope stent with increased radiation field strength at the ends of the stent |
NL1002044C2 (en) | 1996-01-08 | 1997-07-09 | Optische Ind De Oude Delft Nv | Radioactive source that has clinically relevant beta radiation |
US5722984A (en) | 1996-01-16 | 1998-03-03 | Iso Stent, Inc. | Antithrombogenic radioactive coating for an intravascular stent |
US5800333A (en) | 1996-02-20 | 1998-09-01 | United States Surgical Corporation | Afterloader provided with remote control unit |
US5882290A (en) | 1996-02-29 | 1999-03-16 | Scimed Life Systems, Inc. | Intravascular radiation delivery system |
US6234951B1 (en) | 1996-02-29 | 2001-05-22 | Scimed Life Systems, Inc. | Intravascular radiation delivery system |
US5855546A (en) | 1996-02-29 | 1999-01-05 | Sci-Med Life Systems | Perfusion balloon and radioactive wire delivery system |
US5897573A (en) | 1996-04-26 | 1999-04-27 | Rosenthal; David | Radioactive medical suture and method of making the same |
US5916143A (en) | 1996-04-30 | 1999-06-29 | Apple; Marc G. | Brachytherapy catheter system |
CA2202421A1 (en) | 1996-05-29 | 1997-11-29 | Joseph P. Loeffler | Radiation-emitting flow-through temporary stent |
US5843163A (en) | 1996-06-06 | 1998-12-01 | Wall; William H. | Expandable stent having radioactive treatment means |
NL1003543C2 (en) | 1996-07-08 | 1998-01-12 | Optische Ind Oede Oude Delftoe | Brachytherapy capsule and brachytherapy capsule assembly and guide. |
US5871436A (en) | 1996-07-19 | 1999-02-16 | Advanced Cardiovascular Systems, Inc. | Radiation therapy method and device |
US5795286A (en) | 1996-08-15 | 1998-08-18 | Cathco, Inc. | Radioisotope impregnated sheet of biocompatible material for preventing scar tissue formation |
US5820553A (en) | 1996-08-16 | 1998-10-13 | Siemens Medical Systems, Inc. | Identification system and method for radiation therapy |
US5782740A (en) | 1996-08-29 | 1998-07-21 | Advanced Cardiovascular Systems, Inc. | Radiation dose delivery catheter with reinforcing mandrel |
US5910101A (en) | 1996-08-29 | 1999-06-08 | Advanced Cardiovascular Systems, Inc. | Device for loading and centering a vascular radiation therapy source |
US5947924A (en) | 1996-09-13 | 1999-09-07 | Angiorad, L.L.C. | Dilatation/centering catheter used for the treatment of stenosis or other constriction in a bodily passageway and method thereof |
DE69739342D1 (en) | 1996-09-23 | 2009-05-14 | Best Vascular Inc | |
US5924973A (en) | 1996-09-26 | 1999-07-20 | The Trustees Of Columbia University In The City Of New York | Method of treating a disease process in a luminal structure |
US5882291A (en) | 1996-12-10 | 1999-03-16 | Neocardia, Llc | Device and method for controlling dose rate during intravascular radiotherapy |
US5871437A (en) | 1996-12-10 | 1999-02-16 | Inflow Dynamics, Inc. | Radioactive stent for treating blood vessels to prevent restenosis |
US6231719B1 (en) | 1996-12-31 | 2001-05-15 | Kimberly-Clark Worldwide, Inc. | Uncreped throughdried tissue with controlled coverage additive |
US5873811A (en) | 1997-01-10 | 1999-02-23 | Sci-Med Life Systems | Composition containing a radioactive component for treatment of vessel wall |
US5910102A (en) | 1997-01-10 | 1999-06-08 | Scimed Life Systems, Inc. | Conversion of beta radiation to gamma radiation for intravascular radiation therapy |
US5816259A (en) | 1997-01-13 | 1998-10-06 | Rose; Samuel | Method for the diagnosis and treatment of cancer by the accumulation of radioactive precipitates in targeted cells |
US5879282A (en) | 1997-01-21 | 1999-03-09 | Cordis A Johnson And Johnson Company | Catheter having an expandable radioactive source |
US5863285A (en) | 1997-01-30 | 1999-01-26 | Cordis Corporation | Balloon catheter with radioactive means |
US5782742A (en) | 1997-01-31 | 1998-07-21 | Cardiovascular Dynamics, Inc. | Radiation delivery balloon |
US6059713A (en) | 1997-03-06 | 2000-05-09 | Scimed Life Systems, Inc. | Catheter system having tubular radiation source with movable guide wire |
US5865720A (en) | 1997-03-06 | 1999-02-02 | Scimed Life Systems, Inc. | Expandable and retrievable radiation delivery system |
US6110097A (en) | 1997-03-06 | 2000-08-29 | Scimed Life Systems, Inc. | Perfusion balloon catheter with radioactive source |
US6059812A (en) | 1997-03-21 | 2000-05-09 | Schneider (Usa) Inc. | Self-expanding medical device for centering radioactive treatment sources in body vessels |
US6033357A (en) | 1997-03-28 | 2000-03-07 | Navius Corporation | Intravascular radiation delivery device |
US5925353A (en) | 1997-04-01 | 1999-07-20 | Set Ltd | Targeted radioimmunotherapy |
ATE258447T1 (en) | 1997-04-26 | 2004-02-15 | Univ Karlsruhe | RADIONUCLIDE MICROPARTICLES IN COMPOUND WITH ELASTOMERIC TUBING FOR ENDOVASCULAR THERAPY |
DE19724223C1 (en) | 1997-04-30 | 1998-12-24 | Schering Ag | Production of radioactive coated stent, especially at point of use |
US6200307B1 (en) | 1997-05-22 | 2001-03-13 | Illumenex Corporation | Treatment of in-stent restenosis using cytotoxic radiation |
US6019718A (en) | 1997-05-30 | 2000-02-01 | Scimed Life Systems, Inc. | Apparatus for intravascular radioactive treatment |
DE19724233C2 (en) | 1997-06-03 | 2003-10-16 | Sms Demag Ag | Process for avoiding or reducing trumpet-shaped widenings at the pipe end when cross-rolling thin-walled pipes and device for carrying out the process |
US5906573A (en) | 1997-07-18 | 1999-05-25 | Radiomed Corporation | Radioactive surgical fastening devices and methods of making same |
US6106454A (en) | 1997-06-17 | 2000-08-22 | Medtronic, Inc. | Medical device for delivering localized radiation |
US6024690A (en) | 1997-07-01 | 2000-02-15 | Endosonics Corporation | Radiation source with delivery wire |
US6048300A (en) | 1997-07-03 | 2000-04-11 | Guidant Corporation | Compact cartridge for afterloader |
US5919126A (en) | 1997-07-07 | 1999-07-06 | Implant Sciences Corporation | Coronary stent with a radioactive, radiopaque coating |
US5816999A (en) | 1997-07-24 | 1998-10-06 | Bischoff; Jeffrey | Flexible catheter for the delivery of ionizing radiation to the interior of a living body |
US5913813A (en) | 1997-07-24 | 1999-06-22 | Proxima Therapeutics, Inc. | Double-wall balloon catheter for treatment of proliferative tissue |
AU738093B2 (en) | 1997-09-11 | 2001-09-06 | Marc G. Apple | Medical radiation treatment delivery apparatus |
US6010445A (en) | 1997-09-11 | 2000-01-04 | Implant Sciences Corporation | Radioactive medical device and process |
ATE227145T1 (en) | 1997-09-26 | 2002-11-15 | Schneider Europ Gmbh | BALLOON CATHETER INFLATED WITH CARBON DIOXIDE FOR RADIOTHERAPY |
US5938582A (en) | 1997-09-26 | 1999-08-17 | Medtronic, Inc. | Radiation delivery centering catheter |
EP0904799A1 (en) | 1997-09-26 | 1999-03-31 | Schneider (Europe) GmbH | Dilation catheter with balloon having a determined ration of balloon volume and square surface of the inflation lumen |
US6254552B1 (en) | 1997-10-03 | 2001-07-03 | E.I. Du Pont De Nemours And Company | Intra-coronary radiation devices containing Ce-144 or Ru-106 |
US6030333A (en) | 1997-10-24 | 2000-02-29 | Radiomed Corporation | Implantable radiotherapy device |
US6264596B1 (en) | 1997-11-03 | 2001-07-24 | Meadox Medicals, Inc. | In-situ radioactive medical device |
US5851171A (en) | 1997-11-04 | 1998-12-22 | Advanced Cardiovascular Systems, Inc. | Catheter assembly for centering a radiation source within a body lumen |
AU737378B2 (en) | 1997-12-05 | 2001-08-16 | Cook Incorporated | Medical radiation treatment device |
US5957829A (en) | 1997-12-17 | 1999-09-28 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for radiotherapy using a radioactive source wire having a magnetic insert |
US6149574A (en) | 1997-12-19 | 2000-11-21 | Radiance Medical Systems, Inc. | Dual catheter radiation delivery system |
KR100228188B1 (en) | 1997-12-24 | 1999-11-01 | 김성년 | A radioactive stent and process for preparation thereof |
KR100228187B1 (en) | 1997-12-24 | 1999-11-01 | 김성년 | A radioactive ballon used in balloon dilatation catherer and process for preparation thereof |
DE19758234C2 (en) | 1997-12-30 | 2003-04-17 | Anwer Puthawala | Use of a radioactive catheter |
US5997462A (en) | 1998-01-08 | 1999-12-07 | Delft Instruments Intellectual Property B.V. | Method and apparatus for treating a blood vessel lesion |
US5961439A (en) | 1998-05-06 | 1999-10-05 | United States Surgical Corporation | Device and method for radiation therapy |
AU2320299A (en) | 1998-01-14 | 1999-08-02 | United States Surgical Corporation | Device and method for radiation therapy |
US6224535B1 (en) | 1998-02-17 | 2001-05-01 | Advanced Cardiovascular Systems, Inc. | Radiation centering catheters |
WO1999042177A1 (en) | 1998-02-19 | 1999-08-26 | Radiance Medical Systems, Inc. | Radioactive stent |
US6293899B1 (en) | 1998-03-24 | 2001-09-25 | Radiomed Corporation | Transmutable radiotherapy device |
US5997463A (en) | 1998-03-26 | 1999-12-07 | North American Scientific | Laser welded brachytherapy source and method of making the same |
US6267717B1 (en) | 1998-03-31 | 2001-07-31 | Advanced Research & Technology Institute | Apparatus and method for treating a body structure with radiation |
US6013019A (en) | 1998-04-06 | 2000-01-11 | Isostent, Inc. | Temporary radioisotope stent |
SG90196A1 (en) | 1998-05-04 | 2002-07-23 | Novoste Corp | Intraluminal radiation treatment system |
US6238332B1 (en) | 1998-05-07 | 2001-05-29 | Uni-Cath Inc. | Radiation device with shield portion |
US6296603B1 (en) | 1998-05-26 | 2001-10-02 | Isostent, Inc. | Radioactive intraluminal endovascular prosthesis and method for the treatment of aneurysms |
US6050930A (en) | 1998-06-02 | 2000-04-18 | Teirstein; Paul S. | Irradiation catheter with expandable source |
US6053858A (en) | 1998-06-04 | 2000-04-25 | Advanced Cardiovascular Systems, Inc. | Radiation source |
DE19825563C1 (en) | 1998-06-08 | 1999-12-02 | Siemens Ag | Catheter X=ray tube |
DE19825999A1 (en) | 1998-06-10 | 1999-12-23 | Siemens Ag | System for intracorporeal and intraluminal X-ray therapy |
DE19826000C1 (en) | 1998-06-10 | 1999-12-30 | Siemens Ag | Catheter assembly for intracorporal X-ray therapeutic treatment |
JP3090314B2 (en) | 1998-06-24 | 2000-09-18 | エックスアールティー コーポレイション | Apparatus for applying localized X-ray radiation inside a target object and method for manufacturing the same |
DE19829444A1 (en) | 1998-07-01 | 2000-01-27 | Siemens Ag | Miniature X=ray tube for insertion into blood vessel of organism |
DE19829447A1 (en) | 1998-07-01 | 2000-01-05 | Siemens Ag | X-ray radiation catheter for treatment of vascular wall |
US6149575A (en) | 1998-07-07 | 2000-11-21 | World Medical Manufacturing Corporation | Radiation delivery catheter |
JP2002524108A (en) | 1998-07-28 | 2002-08-06 | インナーダイン, インコーポレイテッド | Absorbable brachytherapy and chemotherapy delivery devices and methods |
US6264598B1 (en) | 1998-08-06 | 2001-07-24 | Implant Sciences Corporation | Palladium coated implant |
JP3386724B2 (en) | 1998-09-08 | 2003-03-17 | 株式会社椿本チエイン | Synchronous belt with positioning confirmation function |
IL126341A0 (en) | 1998-09-24 | 1999-05-09 | Medirad I R T Ltd | Radiation delivery devices and methods of making same |
US6099455A (en) | 1998-11-25 | 2000-08-08 | Isostent, Inc. | Radioisotope stent with non-radioactive end sections |
US6264595B1 (en) | 1999-02-04 | 2001-07-24 | Mobeta, Inc. | Radioactive transition metal stents |
US6224536B1 (en) | 1999-02-08 | 2001-05-01 | Advanced Cardiovascular Systems | Method for delivering radiation therapy to an intravascular site in a body |
US6200256B1 (en) | 1999-03-17 | 2001-03-13 | The Trustees Of Columbia University In The City Of New York | Apparatus and method to treat a disease process in a luminal structure |
US6090035A (en) | 1999-03-19 | 2000-07-18 | Isostent, Inc. | Stent loading assembly for a self-expanding stent |
US6200257B1 (en) | 1999-03-24 | 2001-03-13 | Proxima Therapeutics, Inc. | Catheter with permeable hydrogel membrane |
US6241719B1 (en) | 1999-05-13 | 2001-06-05 | Micro Therapeutics, Inc. | Method for forming a radioactive stent |
JP3190642B2 (en) | 1999-06-28 | 2001-07-23 | オリンパス光学工業株式会社 | Laser probe |
US6213976B1 (en) | 1999-07-22 | 2001-04-10 | Advanced Research And Technology Institute, Inc. | Brachytherapy guide catheter |
US6203485B1 (en) | 1999-10-07 | 2001-03-20 | Scimed Life Systems, Inc. | Low attenuation guide wire for intravascular radiation delivery |
-
2000
- 2000-03-09 US US09/522,122 patent/US6416457B1/en not_active Expired - Fee Related
-
2001
- 2001-01-29 JP JP2001564837A patent/JP2003525714A/en active Pending
- 2001-01-29 WO PCT/US2001/002888 patent/WO2001066188A1/en active Search and Examination
- 2001-01-29 EP EP01905187A patent/EP1263502A1/en not_active Withdrawn
- 2001-01-29 CA CA002400416A patent/CA2400416A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6416457B1 (en) | 2002-07-09 |
EP1263502A1 (en) | 2002-12-11 |
JP2003525714A (en) | 2003-09-02 |
WO2001066188A1 (en) | 2001-09-13 |
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