CA2402652A1 - Viscoelastics for use in middle ear surgery - Google Patents

Viscoelastics for use in middle ear surgery Download PDF

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Publication number
CA2402652A1
CA2402652A1 CA002402652A CA2402652A CA2402652A1 CA 2402652 A1 CA2402652 A1 CA 2402652A1 CA 002402652 A CA002402652 A CA 002402652A CA 2402652 A CA2402652 A CA 2402652A CA 2402652 A1 CA2402652 A1 CA 2402652A1
Authority
CA
Canada
Prior art keywords
viscoelastics
middle ear
ear surgery
surgical
surgery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002402652A
Other languages
French (fr)
Other versions
CA2402652C (en
Inventor
Masoud R. Jafari
Uday Doshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon, Inc.
Masoud R. Jafari
Uday Doshi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon, Inc., Masoud R. Jafari, Uday Doshi filed Critical Alcon, Inc.
Publication of CA2402652A1 publication Critical patent/CA2402652A1/en
Application granted granted Critical
Publication of CA2402652C publication Critical patent/CA2402652C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/14—Materials or treatment for tissue regeneration for ear reconstruction or ear implants, e.g. implantable hearing aids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)

Abstract

Disclosed are viscoelastic compositions and methods of their use in surgical and non-surgical packing and in effecting drug delivery, especially in conjunction with trauma to or disorders of the ear.
CA002402652A 2000-03-14 2001-03-14 Viscoelastics for use in middle ear surgery Expired - Fee Related CA2402652C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18917900P 2000-03-14 2000-03-14
US60/189,179 2000-03-14
PCT/US2001/008064 WO2001068079A2 (en) 2000-03-14 2001-03-14 Viscoelastics for use in middle ear surgery

Publications (2)

Publication Number Publication Date
CA2402652A1 true CA2402652A1 (en) 2001-09-20
CA2402652C CA2402652C (en) 2008-11-18

Family

ID=22696258

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002402652A Expired - Fee Related CA2402652C (en) 2000-03-14 2001-03-14 Viscoelastics for use in middle ear surgery

Country Status (13)

Country Link
US (1) US6632423B2 (en)
EP (1) EP1267894B1 (en)
JP (1) JP4746244B2 (en)
AT (1) ATE466583T1 (en)
AU (2) AU4741001A (en)
BR (1) BR0109162A (en)
CA (1) CA2402652C (en)
DE (1) DE60142031D1 (en)
ES (1) ES2343402T3 (en)
HK (1) HK1048765A1 (en)
MX (1) MXPA02008966A (en)
WO (1) WO2001068079A2 (en)
ZA (1) ZA200206696B (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7544348B2 (en) * 2001-02-15 2009-06-09 Access Pharmaceuticals, Inc. Liquid formulations for the prevention and treatment of mucosal diseases and disorders
EP1363600B1 (en) * 2001-02-15 2008-10-01 Access Pharmaceuticals, Inc. Liquid formulations for the prevention and treatment of mucosal diseases and disorders
US20040118414A1 (en) 2002-12-20 2004-06-24 Shah Mandar V Surface modified viscoelastics for ocular surgery
JP4480131B2 (en) * 2001-12-21 2010-06-16 アルコン，インコーポレイテッド Viscoelastic combination for use during surgery
US7363928B2 (en) 2001-12-21 2008-04-29 Alcon, Inc. Dilution resistant viscoelastic compositions
US7820194B2 (en) * 2001-12-21 2010-10-26 Alcon, Inc. Combinations of viscoelastics for use during surgery
US8524213B2 (en) * 2003-12-30 2013-09-03 Genzyme Corporation Polymeric materials, their preparation and use
US20060003964A1 (en) * 2004-06-30 2006-01-05 Shah Mandar V Dilution resistant viscoelastic compositions
WO2006085987A2 (en) * 2004-07-09 2006-08-17 University Of Iowa Research Foundation Rna interference in respiratory epitheial cells
US8313762B2 (en) * 2006-07-05 2012-11-20 Medtronic Xomed, Inc. Flexible bioresorbable hemostatic packing and stent
JP5757861B2 (en) 2008-04-24 2015-08-05 メドトロニック，インコーポレイテッド Chitosan-containing protective composition
EP2310002B1 (en) * 2008-04-24 2016-11-02 Medtronic, Inc Protective gel based on chitosan and oxidized polysaccharide
JP2011518837A (en) 2008-04-24 2011-06-30 メドトロニック，インコーポレイテッド Rehydratable thiolated polysaccharide particles and sponges
JP5653342B2 (en) * 2008-04-24 2015-01-14 メドトロニック，インコーポレイテッド Cold ionizing radiation sterilization
US8030297B2 (en) 2008-05-14 2011-10-04 Otonomy, Inc. Controlled release corticosteroid compositions and methods for the treatment of OTIC disorders
US8318817B2 (en) 2008-07-21 2012-11-27 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
CA2731766C (en) * 2008-07-21 2014-01-28 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
US10806833B1 (en) 2009-05-11 2020-10-20 Integra Lifesciences Corporation Adherent resorbable matrix
US9326943B1 (en) 2009-06-23 2016-05-03 Sandra M. Skovlund Biodegradable prosthesis
US8876795B2 (en) * 2011-02-02 2014-11-04 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
EP2596796B1 (en) 2011-11-24 2013-11-13 Quimera Ingenieria Biomedica, S.L. Complex obtained from hyaluronic acid or a salt thereof and chondroitin sulphate mixtures
WO2015031393A1 (en) 2013-08-27 2015-03-05 Otonomy, Inc. Treatment of pediatric otic disorders
CN105903087A (en) * 2015-12-14 2016-08-31 上海其胜生物制剂有限公司 Preparation method of viscoelastic agent with cohesiveness and dispersivity
US11040004B2 (en) 2016-09-16 2021-06-22 Otonomy, Inc. Otic gel formulations for treating otitis externa
CN106821980B (en) * 2017-02-17 2019-10-18 成都博创必成生物技术有限公司 A kind of nasal mist and preparation method thereof and biological barrier film
MX2022001374A (en) 2019-07-31 2022-03-17 Astellas Pharma Inc Pharmaceutical composition for otic administration.
CN114224609B (en) * 2021-12-14 2024-01-30 曹佩培 Middle ear/eustachian tube anti-adhesion film and preparation method thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141973A (en) 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US5166331A (en) 1983-10-10 1992-11-24 Fidia, S.P.A. Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
US6051560A (en) 1986-06-26 2000-04-18 Nestle S.A. Chrondroitin sulfate/sodium hyaluronate composition
US5290552A (en) * 1988-05-02 1994-03-01 Matrix Pharmaceutical, Inc./Project Hear Surgical adhesive material
ATE111360T1 (en) * 1988-05-02 1994-09-15 Project Hear SURGICAL ADHESIVE MATERIAL.
US5273056A (en) * 1992-06-12 1993-12-28 Alcon Laboratories, Inc. Use of combinations of viscoelastics during surgery
DE69432188T2 (en) 1993-04-30 2004-01-22 Nestle S.A. Synthetic viscose elastic material for physiological applications such as for ophthalmic applications
US5501706A (en) * 1994-11-29 1996-03-26 Wildflower Communications, Inc. Medical implant structure and method for using the same
US5811453A (en) * 1994-12-23 1998-09-22 Alcon Laboratories, Inc. Viscoelastic compositions and methods of use
US5972326A (en) 1995-04-18 1999-10-26 Galin; Miles A. Controlled release of pharmaceuticals in the anterior chamber of the eye
AU725654B2 (en) * 1996-05-03 2000-10-19 Innogenetics N.V. New medicaments containing gelatin cross-linked with oxidized polysaccharides

Also Published As

Publication number Publication date
US6632423B2 (en) 2003-10-14
ZA200206696B (en) 2003-08-21
ES2343402T3 (en) 2010-07-30
AU4741001A (en) 2001-09-24
WO2001068079A2 (en) 2001-09-20
ATE466583T1 (en) 2010-05-15
CA2402652C (en) 2008-11-18
EP1267894B1 (en) 2010-05-05
JP2003534036A (en) 2003-11-18
WO2001068079A3 (en) 2002-07-25
DE60142031D1 (en) 2010-06-17
JP4746244B2 (en) 2011-08-10
AU2001247410B2 (en) 2005-05-12
HK1048765A1 (en) 2003-04-17
EP1267894A2 (en) 2003-01-02
MXPA02008966A (en) 2003-02-12
BR0109162A (en) 2005-01-11
US20020169142A1 (en) 2002-11-14

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EEER Examination request
MKLA Lapsed

Effective date: 20130314