CA2404617A1 - Method and apparatus for assessing neural function by sparse stimuli - Google Patents
Method and apparatus for assessing neural function by sparse stimuli Download PDFInfo
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- CA2404617A1 CA2404617A1 CA002404617A CA2404617A CA2404617A1 CA 2404617 A1 CA2404617 A1 CA 2404617A1 CA 002404617 A CA002404617 A CA 002404617A CA 2404617 A CA2404617 A CA 2404617A CA 2404617 A1 CA2404617 A1 CA 2404617A1
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- stimulus
- null
- condition
- stimuli
- stimulus condition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
- A61B5/377—Electroencephalography [EEG] using evoked responses
- A61B5/378—Visual stimuli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
- A61B5/4064—Evaluating the brain
Abstract
A method and an apparatus are described for simultaneously assessing the functional status of component parts of the nervous system by presenting sparse stimuli to one or more parts of the sensory nervous system. Sparse stimuli consist of temporal sequences of stimulus conditions presented against a baseline null stimulus condition, where the non-null stimulus condition, or conditions, are presented relatively infrequently. The low probability of encountering a stimulus differing from a baseline or null stimulus condition in sparse stimulus sequences insures that gain control mechanisms within the nervous system will increase the neural response magnitude and also bias the measured responses to those neurone populations having such gain controls. The con-sequently increased response amplitudes ensure more reliably recorded responses than are obtained with non-sparse stimuli.
Claims (40)
1. A method for simultaneously assessing the functional status of component parts of the nervous system of a subject, said method comprising:
(a) presenting to one or more parts of the sensory nervous system of the subject stimulus sequences having different temporal modulation sequences of the appropriate stimulus modality for each stimulated part of the sensory nervous system, the stimuli having different sequences for each stimulated part;
(b) temporally modulating the stimuli between a null stimulus condition and at least one non-null stimulus condition selected from the group consisting of an increment stimulus condition and a decrement stimulus condition, relative to the null stimulus condition, wherein the probability of encountering the null stimulus condition in the stimulus sequences is higher compared to the probability of encountering at least one non-null stimulus condition, and wherein the temporally modulated stimuli permit estimation of linear and non-linear weighting functions characterising measured responses to each stimulus presented to each part of the nervous system;
(c) estimating some or all of the coefficients of the linear and non-linear weighting functions for each stimulus sequence from the measured responses to said stimuli, to isolate separate responses from the separately and simultaneously stimulated component parts of the nervous system; and (d) estimating separate coefficients for responses to said other stimulus conditions to permit isolation of separate responses from component parts of the nervous system that respond to distinct members of said other stimulus conditions.
(a) presenting to one or more parts of the sensory nervous system of the subject stimulus sequences having different temporal modulation sequences of the appropriate stimulus modality for each stimulated part of the sensory nervous system, the stimuli having different sequences for each stimulated part;
(b) temporally modulating the stimuli between a null stimulus condition and at least one non-null stimulus condition selected from the group consisting of an increment stimulus condition and a decrement stimulus condition, relative to the null stimulus condition, wherein the probability of encountering the null stimulus condition in the stimulus sequences is higher compared to the probability of encountering at least one non-null stimulus condition, and wherein the temporally modulated stimuli permit estimation of linear and non-linear weighting functions characterising measured responses to each stimulus presented to each part of the nervous system;
(c) estimating some or all of the coefficients of the linear and non-linear weighting functions for each stimulus sequence from the measured responses to said stimuli, to isolate separate responses from the separately and simultaneously stimulated component parts of the nervous system; and (d) estimating separate coefficients for responses to said other stimulus conditions to permit isolation of separate responses from component parts of the nervous system that respond to distinct members of said other stimulus conditions.
2. The method of claim 1, wherein a stimulus sequence comprises a null stimulus condition and two non-null stimulus conditions comprising an increment stimulus condition characterised by an increment of a parameter relative to the null stimulus condition, and a decrement stimulus condition characterised by a decrement of a parameter relative to the null stimulus condition, wherein said non-null stimulus conditions are presented at a lower frequency relative to said null stimulus condition.
3. The method of claim 1, wherein a stimulus sequence comprises a null stimulus condition and a single non-null stimulus condition, wherein said non-null stimulus condition is presented at a lower frequency relative to said null stimulus condition.
4. The method of claim 1, wherein a stimulus sequence comprises a null stimulus condition and a number of non-null stimulus conditions wherein said non-null stimulus conditions are presented at a lower frequency relative to said null stimulus condition.
5. The method of claim 1, wherein at least one the non-null condition occurs with an average frequency of between about 0.25 and about 25 per second.
6. The method of claim 5, wherein the at least one non-null condition occurs with an average frequency of between about 1 and about 6 per second.
7. The method of claim 6, wherein the stimulation is selected from tactile stimuli, auditory stimuli, visual stimuli or a combination thereof.
8. The method of claim 1, wherein the at least one non-null condition comprises stimulation by visual stimuli.
9. The method of claim 8, wherein the visual stimuli are selected from different luminance or contrast levels.
10. The method of claim 8, wherein a stimulus sequence comprises a null stimulus condition and two non-null stimulus conditions comprising an increment stimulus condition characterised by an increment of a parameter relative to the null stimulus condition, and a decrement stimulus condition characterised by a decrement of a parameter relative to the null stimulus condition, wherein said non-null stimulus conditions are presented at a lower frequency relative to said null stimulus condition.
11. The method of claim 10, wherein the parameter is relative stimulus contrast.
12. The method of claim 8, wherein a stimulus sequence comprises a null stimulus condition and a single non-null stimulus condition, wherein said non-null stimulus condition is presented at a lower frequency relative to said null stimulus condition.
13. The method of claim 12, wherein the parameter is luminance.
14. The method of claim 8, wherein the step of presenting (step (a)) comprises:
- dividing the visual field of view of each eye of the subject into a plurality of stimulus regions so as to roughly isolate confluent streams within the optic nerve, optic radiations and visual cortex due to their retinotopic arrangement and/or to stimulate different parts of areas of the brain concerned with vision; and - presenting to the two eyes stimuli having different temporal modulation of the appearance of each of the visual field of each eye, the stimuli being different for each of the corresponding regions within the visual field of view of each eye.
- dividing the visual field of view of each eye of the subject into a plurality of stimulus regions so as to roughly isolate confluent streams within the optic nerve, optic radiations and visual cortex due to their retinotopic arrangement and/or to stimulate different parts of areas of the brain concerned with vision; and - presenting to the two eyes stimuli having different temporal modulation of the appearance of each of the visual field of each eye, the stimuli being different for each of the corresponding regions within the visual field of view of each eye.
15. The method of claim 14, wherein the visual field is divided into quadrants partitioning the visual field along axes defining at least one member selected from the group consisting of the temporal, nasal, inferior and superior visual fields and concentrically organized partitions of these quadrants, which permits separate stimulation of central and peripheral parts of the visual field.
16. The method of claim 14, wherein the stimuli comprise modulation of the luminance or contrast of elements within each of the stimulus regions between two or three luminance levels or between two or three contrast levels.
17. The method of claim 16, wherein the function governing alternation between the levels is approximately uniformly distributed noise.
18. The method of claim 16, wherein the stimuli comprise modulation of an additional parameter selected from the group or position, or apparent depth of color of elements of the stimulus zones between two or three levels and the function governing alternation between the levels is approximately uniformly distributed noise.
19. The method of claim 1, wherein the temporally modulated stimuli are sufficiently complex so as to permit estimation of linear and non-linear weighting functions characterising the measured responses to each stimulus presented to each part of the nervous system.
20. The method of claim 1, wherein the stimulus sequences comprise aperiodic or pseudorandom stimulus sequences.
21. The method of claim 1, wherein the linear and non-linear weighting functions are Wiener or Volterra kernels.
22. The method of claim 21, wherein the latency to selected peaks within time course of linear kernels and/or the shape of the kernels or their amplitudes are used as measures of the functional status of component parts of the nervous system.
23. An apparatus for assessing the functional status of component parts of the nervous system, comprising:
- stimulation means for presenting to the sensory nervous system of a test subject stimulus sequences having different temporal modulation sequences of the appropriate stimulus modality for each stimulated part of the sensory nervous system, the stimuli having different sequences for each stimulated part, wherein the stimulation means comprises means for fluctuating the temporally modulated stimuli between a null stimulus condition and at least one non-null stimulus condition selected from the group consisting of an increment stimulus condition and a decrement stimulus condition, relative to the null stimulus condition, wherein the probability of encountering the null stimulus condition in the stimulus sequences is higher compared to the probability of encountering the at least one non-null stimulus condition, and wherein the temporally modulated stimuli permit estimation of linear and non-linear weighting functions characterising measured responses to each stimulus presented to each part of the nervous system;
- monitoring means for monitoring responses to said stimulus sequences in said test subject; and - processing means for determining coefficients of linear and non-linear weighting functions for each stimulus sequence from the measured responses to said stimuli.
- stimulation means for presenting to the sensory nervous system of a test subject stimulus sequences having different temporal modulation sequences of the appropriate stimulus modality for each stimulated part of the sensory nervous system, the stimuli having different sequences for each stimulated part, wherein the stimulation means comprises means for fluctuating the temporally modulated stimuli between a null stimulus condition and at least one non-null stimulus condition selected from the group consisting of an increment stimulus condition and a decrement stimulus condition, relative to the null stimulus condition, wherein the probability of encountering the null stimulus condition in the stimulus sequences is higher compared to the probability of encountering the at least one non-null stimulus condition, and wherein the temporally modulated stimuli permit estimation of linear and non-linear weighting functions characterising measured responses to each stimulus presented to each part of the nervous system;
- monitoring means for monitoring responses to said stimulus sequences in said test subject; and - processing means for determining coefficients of linear and non-linear weighting functions for each stimulus sequence from the measured responses to said stimuli.
24. The apparatus of claim 23, wherein the stimulation means comprises means for presenting a stimulus sequence comprising a null stimulus condition and two non-null stimulus conditions comprising an increment stimulus condition characterised by an increment of a parameter relative to the baseline stimulus condition, and a decrement stimulus condition characterised by a decrement of a parameter relative to the null stimulus condition, wherein said non-null stimulus conditions are presented at a lower frequency relative to said null stimulus condition.
25. The apparatus of claim 23, wherein the stimulation means comprises means for presenting a stimulus sequence comprising a null stimulus condition and a single non-null stimulus condition, wherein said non-null stimulus condition is presented at a lower frequency relative to said null stimulus condition.
26. The apparatus of claim 23, wherein the stimulation means comprises means for presenting at least one the non-null condition at an average frequency of between about 0.25 and about 25 per second.
27. The apparatus of claim 23, wherein the stimulation means comprises means for presenting the at least one non-null condition at an average frequency of between about 1 and about 6 per second.
28. The apparatus of claim 23, wherein the stimulation means comprises means for stimulating a sensory modality.
29. The apparatus of claim 23, wherein the stimulation means comprises means for stimulating the visual senses.
30. The apparatus of claim 23, wherein the stimulation means comprises means for presenting different luminance levels.
31. The apparatus of claim 23, wherein the stimulation means comprises means for presenting different contrast levels.
32. The apparatus of claim 23, wherein the stimulation means comprises means for presenting a stream of separate, viewing images presented to each eye.
33. The apparatus of claim 32, wherein the separate viewing images comprise images of different contrast levels.
34. The apparatus of claim 32, wherein the separate viewing images comprise images of different luminance levels.
35. The apparatus of claim 32, wherein the stimulation means comprises means for presenting to each eye a plurality of stimulus regions so as to roughly isolate confluent streams within the optic nerve, optic radiations and visual cortex due to their retinotopic arrangement and/or to stimulate different parts of areas of the brain concerned with vision.
36. The apparatus of claim 32, wherein the stimulation means further comprises means for presenting to the two eyes stimuli having different temporal modulation of the appearance of each of the visual field of each eye, the stimuli being different for each of the corresponding regions within the visual field of view of each eye.
37. The apparatus of claim 36, wherein the visual field is divided into quadrants partitioning the visual field along axes defining at least one member selected from the group consisting of the temporal, nasal, inferior and superior visual fields and concentrically organized partitions of these quadrants, which permits separate stimulation of central and peripheral parts of the visual field.
38. The apparatus of claim 23, wherein the monitoring means comprises recordal means for recording responses to said stimulus sequences in said test subject.
39. The apparatus of claim 38, wherein the recordal means records visual evoked potentials to provide an objective indication of the said responses.
40. The apparatus of claim 23, wherein the processing means comprises timing means and means for receiving signals from the recordal means indicative of said response.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPQ6465 | 2000-03-27 | ||
| AUPQ6465A AUPQ646500A0 (en) | 2000-03-27 | 2000-03-27 | Method and apparatus for assessing neural function by sparse stimuli |
| PCT/AU2001/000343 WO2001072211A1 (en) | 2000-03-27 | 2001-03-27 | Method and apparatus for assessing neural function by sparse stimuli |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2404617A1 true CA2404617A1 (en) | 2001-10-04 |
| CA2404617C CA2404617C (en) | 2010-12-14 |
Family
ID=3820562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2404617A Expired - Fee Related CA2404617C (en) | 2000-03-27 | 2001-03-27 | Method and apparatus for assessing neural function by sparse stimuli |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7006863B2 (en) |
| EP (1) | EP1267703B1 (en) |
| JP (1) | JP4846163B2 (en) |
| AT (1) | ATE488172T1 (en) |
| AU (1) | AUPQ646500A0 (en) |
| CA (1) | CA2404617C (en) |
| DE (1) | DE60143474D1 (en) |
| WO (1) | WO2001072211A1 (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60336482D1 (en) | 2002-08-16 | 2011-05-05 | Kandel Joel | FEATURES |
| GB0309049D0 (en) * | 2003-04-22 | 2003-05-28 | Univ Manchester | Nervous system monitoring method |
| AU2004292339B2 (en) * | 2003-11-28 | 2010-12-02 | Konan Medical Usa Inc | Assessment of neural function |
| EP1694206B1 (en) * | 2003-11-28 | 2016-04-13 | The Australian National University | Assessment of neural function |
| US7524064B2 (en) * | 2004-03-09 | 2009-04-28 | Research Foundation Of The State University Of New York | Apparatus and method for assessing retinal damage |
| ES2246174B1 (en) * | 2004-07-29 | 2006-11-01 | Universitat De Valencia | DEVICE AND PROCEDURE TO DETERMINE SENSITIVITY TO THE CONTRAST OF THE VISUAL SYSTEM OF A SUBJECT. |
| GB0513603D0 (en) * | 2005-06-30 | 2005-08-10 | Univ Aberdeen | Vision exercising apparatus |
| WO2007144711A2 (en) * | 2006-06-12 | 2007-12-21 | National University Of Ireland Maynooth | Method and apparatus for evoking a response from a subject |
| US8374673B2 (en) | 2007-01-25 | 2013-02-12 | Warsaw Orthopedic, Inc. | Integrated surgical navigational and neuromonitoring system having automated surgical assistance and control |
| US7987001B2 (en) | 2007-01-25 | 2011-07-26 | Warsaw Orthopedic, Inc. | Surgical navigational and neuromonitoring instrument |
| US8880180B2 (en) * | 2007-07-13 | 2014-11-04 | Cochlear Limited | Assessing neural survival |
| US8083354B2 (en) * | 2007-10-03 | 2011-12-27 | Diopsys, Inc. | Simultaneously multi-temporal visual test and method and apparatus therefor |
| AU2008324705B2 (en) * | 2007-11-09 | 2014-02-13 | Konan Medical Usa Inc | Method and apparatus for sensory field assessment |
| US7810928B2 (en) * | 2008-02-26 | 2010-10-12 | Konan Medical Usa, Inc. | Evaluating pupillary responses to light stimuli |
| WO2010006180A1 (en) * | 2008-07-09 | 2010-01-14 | Mckinley Laurence M | Optic function monitoring process and apparatus |
| CA2745486C (en) * | 2008-12-05 | 2017-03-28 | The Australian National University | Pupillary assessment method and apparatus |
| WO2010141764A2 (en) * | 2009-06-03 | 2010-12-09 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Steady state measurement and analysis approach to profiling auditory evoked potentials from short-latency to long-latency |
| US20140012152A1 (en) * | 2011-12-19 | 2014-01-09 | NystAssist, LLC | Method of Decreasing Sensory Latency |
| AU2013350326B2 (en) | 2012-11-26 | 2018-11-08 | Konan Medical Usa Inc | Clustered volley method and apparatus |
| US11166672B2 (en) | 2013-10-18 | 2021-11-09 | Atlantic Health System, Inc. | Nerve protecting dissection device |
| US10022090B2 (en) | 2013-10-18 | 2018-07-17 | Atlantic Health System, Inc. | Nerve protecting dissection device |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4131113A (en) * | 1976-08-19 | 1978-12-26 | California Institute Of Technology | ERG analysis system |
| US4094307A (en) * | 1977-02-24 | 1978-06-13 | Young Jr David N | Method and apparatus for aiding in the anatomical localization of dysfunction in a brain |
| US4421122A (en) * | 1981-05-15 | 1983-12-20 | The Children's Medical Center Corporation | Brain electrical activity mapping |
| US4832480A (en) * | 1986-06-24 | 1989-05-23 | Quintron, Inc. | Differential diagnosis of sensory abnormalities using a normalized, ratiometric analysis of steady state evoked potentials |
| US4846567A (en) * | 1986-08-06 | 1989-07-11 | Sutter Erich E | Retinal area response mapping using simultaneous multi-area stimulation with binary sequences and objective response analysis |
| NL9100740A (en) * | 1991-04-29 | 1992-11-16 | Eduard Naumovich Lerner | APPARATUS FOR APPLICATION IN DETERMINING THE STATE OF THE VEGETATIVE PART OF THE NERVOUS SYSTEM OF AN ORGANISM. |
| GB9418872D0 (en) * | 1994-09-19 | 1994-11-09 | Special Trustees For The Unite | Electrophysiological data collection system |
| US5746205A (en) * | 1996-03-01 | 1998-05-05 | Helsinki University Licensing, Ltd. | Method and apparatus for measuring the working condition of the brain with periodic stimuli |
| DE19649858C2 (en) * | 1996-12-02 | 1999-05-06 | Cindatec Ingenieurtechnische D | Method and arrangement for determining the topography for reaction signals of an eye |
| US6406438B1 (en) * | 1997-12-19 | 2002-06-18 | Medical Research Counsel | Method and apparatus for obtaining evoked otoacoustic emissions |
| US6086206A (en) * | 1998-01-05 | 2000-07-11 | Sutter; Erich E. | Analysis method for enhancing and extracting second order nonlinear response components of the multi-area electroretinogram |
| AUPP266198A0 (en) * | 1998-03-30 | 1998-04-23 | Australian National University, The | Simultaneous binocular assessment of multiple optic nerve and cortical regions in diseases affecting nerve conduction |
-
2000
- 2000-03-27 AU AUPQ6465A patent/AUPQ646500A0/en not_active Abandoned
-
2001
- 2001-03-27 DE DE60143474T patent/DE60143474D1/en not_active Expired - Lifetime
- 2001-03-27 US US10/239,971 patent/US7006863B2/en not_active Expired - Lifetime
- 2001-03-27 EP EP01916739A patent/EP1267703B1/en not_active Expired - Lifetime
- 2001-03-27 WO PCT/AU2001/000343 patent/WO2001072211A1/en active IP Right Grant
- 2001-03-27 JP JP2001570175A patent/JP4846163B2/en not_active Expired - Fee Related
- 2001-03-27 CA CA2404617A patent/CA2404617C/en not_active Expired - Fee Related
- 2001-03-27 AT AT01916739T patent/ATE488172T1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1267703B1 (en) | 2010-11-17 |
| EP1267703A4 (en) | 2004-12-01 |
| US20030163060A1 (en) | 2003-08-28 |
| JP2003527913A (en) | 2003-09-24 |
| CA2404617C (en) | 2010-12-14 |
| WO2001072211A1 (en) | 2001-10-04 |
| JP4846163B2 (en) | 2011-12-28 |
| AUPQ646500A0 (en) | 2000-04-20 |
| DE60143474D1 (en) | 2010-12-30 |
| ATE488172T1 (en) | 2010-12-15 |
| US7006863B2 (en) | 2006-02-28 |
| EP1267703A1 (en) | 2003-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20200831 |