CA2411544A1 - N-alkyl-adamantyl triazinyl benzamide derivatives - Google Patents

N-alkyl-adamantyl triazinyl benzamide derivatives Download PDF

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Publication number
CA2411544A1
CA2411544A1 CA002411544A CA2411544A CA2411544A1 CA 2411544 A1 CA2411544 A1 CA 2411544A1 CA 002411544 A CA002411544 A CA 002411544A CA 2411544 A CA2411544 A CA 2411544A CA 2411544 A1 CA2411544 A1 CA 2411544A1
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Prior art keywords
triazinyl
adamantyl
alkyl
benzamide derivatives
preparation
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CA002411544A
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French (fr)
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CA2411544C (en
Inventor
Allen Jacob Duplantier
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Zoetis P LLC
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Pfizer Products Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
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Abstract

-58- The present invention relates to novel to N-alkyl adamantyl triazinyl benzylamide derivatives of formmula I
CA002411544A 2001-11-12 2002-11-08 N-alkyl-adamantyl triazinyl benzamide derivatives Expired - Fee Related CA2411544C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33689201P 2001-11-12 2001-11-12
US60/336,892 2001-11-12

Publications (2)

Publication Number Publication Date
CA2411544A1 true CA2411544A1 (en) 2003-05-12
CA2411544C CA2411544C (en) 2008-10-07

Family

ID=23318138

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002411544A Expired - Fee Related CA2411544C (en) 2001-11-12 2002-11-08 N-alkyl-adamantyl triazinyl benzamide derivatives

Country Status (10)

Country Link
US (1) US6927219B2 (en)
EP (1) EP1310493B1 (en)
JP (1) JP4001542B2 (en)
AT (1) ATE302196T1 (en)
BR (1) BR0204588A (en)
CA (1) CA2411544C (en)
DE (1) DE60205564T2 (en)
ES (1) ES2244733T3 (en)
MX (1) MXPA02009783A (en)
WO (1) WO2003042190A1 (en)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020182646A1 (en) * 2001-04-30 2002-12-05 Ke Huazhu Methods and products for identifying modulators of P2X7 receptor activity, and their use in the treatment of skeletal disorders
PA8557501A1 (en) * 2001-11-12 2003-06-30 Pfizer Prod Inc BENZAMIDA, HETEROARILAMIDA AND INVESTED AMIDAS
SE0200920D0 (en) * 2002-03-25 2002-03-25 Astrazeneca Ab Novel compounds
US7071223B1 (en) * 2002-12-31 2006-07-04 Pfizer, Inc. Benzamide inhibitors of the P2X7 receptor
PA8591801A1 (en) 2002-12-31 2004-07-26 Pfizer Prod Inc BENZAMID INHIBITORS OF THE P2X7 RECEIVER.
SE0300480D0 (en) * 2003-02-21 2003-02-21 Astrazeneca Ab Novel compounds
ATE371738T1 (en) * 2003-04-17 2007-09-15 Affectis Pharmaceuticals Ag MEANS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF AFFECTIVE DISORDERS
JP4731468B2 (en) * 2003-05-12 2011-07-27 ファイザー・プロダクツ・インク Benzamide inhibitor of P2X7 receptor
EP1644041A1 (en) * 2003-05-29 2006-04-12 AstraZeneca AB A pharmaceutical composition comprising a p2x7 antagonist and sulfasalazine
US20070032465A1 (en) * 2003-05-29 2007-02-08 Nigel Boughton-Smith Pharmaceutical composition comprising a p2x7-receptor antagonist and a tumour necrosis factor alpha
WO2004105796A1 (en) * 2003-05-29 2004-12-09 Astrazeneca Ab A pharmaceutical composition containing a p2x7 receptor antagonist and methotrexate
GB0312609D0 (en) 2003-06-02 2003-07-09 Astrazeneca Ab Novel compounds
SE0302192D0 (en) * 2003-08-08 2003-08-08 Astrazeneca Ab Novel compounds
SE0302488D0 (en) * 2003-09-18 2003-09-18 Astrazeneca Ab New combination
ITMI20040255A1 (en) * 2004-02-17 2004-05-17 Univ Degli Studi Milano ANTIANGIOGENIC ACTIVITY SUBSTANCES
PL1725540T3 (en) * 2004-03-05 2013-02-28 Hoffmann La Roche Diaminopyrimidines as p2x3 and p2x2/3 antagonists
WO2005107804A1 (en) * 2004-05-06 2005-11-17 Ono Pharmaceutical Co., Ltd. Therapeutic agent for respiratory ailment
JP2008504363A (en) * 2004-06-29 2008-02-14 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー Combination therapy using benzamide inhibitor of P2X7 receptor
AU2005258924A1 (en) * 2004-06-29 2006-01-12 Pfizer Products Inc. Method for preparing 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3H-`1,2,4!-triazin-2-YK!benzamide derivatives with P2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presence of a lewis acid
AU2005258911A1 (en) * 2004-06-29 2006-01-12 Pfizer Products Inc. Method for preparing 5-`4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3H`1,2,4!triazin-2-YL!-benzamide derivatives by deprotecting the hydroxyl-protected precursers
SA05260265A (en) * 2004-08-30 2005-12-03 استرازينيكا ايه بي Novel compounds
WO2006035876A1 (en) * 2004-09-29 2006-04-06 Kowa Co., Ltd. Preventive and/or therapeutic medicine for rheumatoid arthritis
SE0402925D0 (en) * 2004-11-30 2004-11-30 Astrazeneca Ab Novel Compounds
WO2006083214A1 (en) * 2005-02-02 2006-08-10 Astrazeneca Ab Pharmaceutical composition comprising a p2x7 receptor antagonist and a hmg-coa reductase inhibitor
KR20080002790A (en) * 2005-03-29 2008-01-04 코와 가부시키가이샤 Preventive and/or therapeutic agent for rheumatoid arthritis
WO2007008157A1 (en) * 2005-07-11 2007-01-18 Astrazeneca Ab New combination 2
EP1906960A4 (en) * 2005-07-11 2010-03-10 Astrazeneca Ab New combination 1
JP4850911B2 (en) * 2005-09-01 2012-01-11 エフ．ホフマン−ラ ロシュ アーゲー Diaminopyrimidines as P2X3 and P2X2 / 3 modulators
CA2619898C (en) * 2005-09-01 2014-03-18 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
CN101300235B (en) 2005-09-01 2011-12-07 弗·哈夫曼-拉罗切有限公司 Diaminopyrimidines as P2X3 and P2X2/3 modulators
CN101296707A (en) * 2005-10-28 2008-10-29 兴和株式会社 Method for prevention and/or treatment of rheumatoid arthritis
JPWO2008001499A1 (en) * 2006-06-29 2009-11-26 興和株式会社 Drugs for preventing and / or treating rheumatoid arthritis
AR065806A1 (en) 2007-03-22 2009-07-01 Astrazeneca Ab DERIVATIVES OF QUINOLINA, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USES FOR THE TREATMENT OF Rheumatoid ARTHRITIS.
WO2009019503A2 (en) * 2007-08-03 2009-02-12 Astrazeneca Ab P2x7 antagonists for use in the treatment of mood disorders
CA2699631A1 (en) 2007-10-31 2009-05-07 Nissan Chemical Industries, Ltd. Pyridazinone compounds and p2x7 receptor inhibitors
PE20091036A1 (en) 2007-11-30 2009-08-15 Astrazeneca Ab QUINOLINE DERIVATIVE AS ANTAGONIST OF THE P2X7 RECEPTOR
WO2009108551A2 (en) * 2008-02-25 2009-09-03 H. Lundbeck A/S Heteroaryl amide analogues
NZ587799A (en) 2008-03-25 2012-06-29 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
ES2380908T3 (en) 2009-04-14 2012-05-21 Affectis Pharmaceuticals Ag Novelty p2x7r antagonists and their use
JP5562716B2 (en) * 2010-05-12 2014-07-30 花王株式会社 Voltage-gated cation channel inhibitor
EP2569281A1 (en) 2010-05-14 2013-03-20 Affectis Pharmaceuticals AG Novel methods for the preparation of p2x7r antagonists
WO2012110190A1 (en) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163456A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163792A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
TW201309706A (en) 2011-07-22 2013-03-01 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as P2X7 receptor antagonists
AU2013210682B2 (en) 2012-01-20 2017-05-25 Idorsia Pharmaceuticals Ltd Heterocyclic amide derivatives as P2X7 receptor antagonists
WO2014091415A1 (en) 2012-12-12 2014-06-19 Actelion Pharmaceuticals Ltd Indole carboxamide derivatives as p2x7 receptor antagonists
EP2935211B1 (en) 2012-12-18 2016-11-09 Actelion Pharmaceuticals Ltd. Indole carboxamide derivatives as p2x7 receptor antagonists
CA2896790C (en) 2013-01-22 2022-05-10 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
EP2956457B1 (en) 2013-01-22 2016-11-23 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
CN103304498B (en) * 2013-06-02 2015-03-04 张远强 Anti-diabetic compound, as well as preparation method and application thereof
CN103304500B (en) * 2013-06-02 2015-03-04 张远强 Novel anti-diabetic compound, as well as preparation method and application thereof
JP6422164B2 (en) 2013-12-26 2018-11-14 塩野義製薬株式会社 Nitrogen-containing 6-membered ring derivatives and pharmaceutical compositions containing them
CN104478859B (en) * 2015-01-13 2016-07-27 佛山市赛维斯医药科技有限公司 A kind of hydroxyadamantane tetrazotized zole compound, Preparation Method And The Use
CN104478861B (en) * 2015-01-13 2016-07-27 佛山市赛维斯医药科技有限公司 A kind of nitro diamantane (obsolete) tetrazotized zole compound, Preparation Method And The Use
CN104478860B (en) * 2015-01-13 2016-08-24 佛山市赛维斯医药科技有限公司 Diamantane (obsolete) tetrazole derivant, Preparation Method And The Use
CN104496968A (en) * 2015-01-13 2015-04-08 佛山市赛维斯医药科技有限公司 Compound with halogen-substituted adamantane tetrazole structure and preparation method and application thereof
CN104447704B (en) * 2015-01-13 2016-07-27 佛山市赛维斯医药科技有限公司 A kind of itrile group diamantane (obsolete) tetrazotized zole compound, Preparation Method And The Use
CN104447703B (en) * 2015-01-13 2016-07-27 佛山市赛维斯医药科技有限公司 A kind of nitro diamantane (obsolete) tetrazotized zole compound, Preparation Method And The Use
US10774051B2 (en) 2015-04-24 2020-09-15 Shionogi & Co., Ltd. 6-membered heterocyclic derivatives and pharmaceutical composition comprising the same
US20180194769A1 (en) 2015-07-06 2018-07-12 Rodin Therapeutics, Inc. Hetero-halo inhibitors of histone deacetylase
EP3319968A1 (en) 2015-07-06 2018-05-16 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
RU2753524C2 (en) 2016-10-17 2021-08-17 Сионоги Энд Ко., Лтд. Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical compositions including them
US10793567B2 (en) 2017-01-11 2020-10-06 Rodin Therapeutics, Inc. Bicyclic inhibitors of histone deacetylase
EP3664802B1 (en) 2017-08-07 2022-02-23 Alkermes, Inc. Bicyclic inhibitors of histone deacetylase
KR102035463B1 (en) * 2018-02-14 2019-11-26 연세대학교 산학협력단 Pharmaceutical composition for treating cancer stem cells

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3789072A (en) * 1970-04-22 1974-01-29 Squibb & Sons Inc Carboxamides
EP0185731A4 (en) * 1984-06-12 1988-11-02 Fmc Corp Herbicidal 2-aryl-1,2,4-triazine-3,5(2h,4h)-diones and sulfur analogs thereof.
US4766233A (en) * 1984-06-12 1988-08-23 Fmc Corporation Herbicidal 2-aryl-1,2,4-triazine-3,5(2H,4H)-diones and sulfur analogs thereof
US5077409A (en) * 1990-05-04 1991-12-31 American Cyanamid Company Method of preparing bis-aryl amide and urea antagonists of platelet activating factor
US5128351A (en) * 1990-05-04 1992-07-07 American Cyanamid Company Bis-aryl amide and urea antagonists of platelet activating factor
KR930703259A (en) 1990-12-17 1993-11-29 알베르투스 빌헬무스 요아네스 쩨스트라텐 Disinfectant Isoquinoline Derivatives
GB9119467D0 (en) 1991-09-12 1991-10-23 Smithkline Beecham Corp Chemical compounds
US5691376A (en) 1994-02-17 1997-11-25 American Home Products Corporation Substituted biphenyl derivatives
US5686061A (en) 1994-04-11 1997-11-11 The Board Of Regents Of The University Of Texas System Particulate contrast media derived from non-ionic water soluble contrast agents for CT enhancement of hepatic tumors
JP3144624B2 (en) 1995-06-02 2001-03-12 杏林製薬株式会社 N-benzyldioxothiazolidylbenzamide derivative and method for producing the same
JP3906935B2 (en) 1995-12-18 2007-04-18 杏林製薬株式会社 N-substituted dioxothiazolidylbenzamide derivative and process for producing the same
ATE267011T1 (en) 1995-12-21 2004-06-15 Bristol Myers Squibb Pharma Co ISOXAZOLINE, ISOTHIAZOLINE AND PYRAZOLINE AS FACTOR XA INHIBITORS
DE69706407T2 (en) * 1996-03-29 2002-05-29 Searle & Co META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTERGRIN ANTAGONISTS OR INHIBITORS
CA2275796A1 (en) 1996-12-23 1998-07-02 Donald Joseph Phillip Pinto Nitrogen containing heteroaromatics as factor xa inhibitors
US6020357A (en) * 1996-12-23 2000-02-01 Dupont Pharmaceuticals Company Nitrogen containing heteroaromatics as factor Xa inhibitors
US6187797B1 (en) * 1996-12-23 2001-02-13 Dupont Pharmaceuticals Company Phenyl-isoxazoles as factor XA Inhibitors
DE19701287A1 (en) * 1997-01-16 1998-07-23 Wernicke & Co Gmbh Process for increasing the service life of grinding wheels
AU6753298A (en) 1997-03-25 1998-10-20 Astra Pharmaceuticals Limited Novel pyridine derivatives and pharmaceutical compositions containing them
WO1998043973A1 (en) 1997-03-27 1998-10-08 Novartis Ag Intermediate products and method for the production of pyrimidine derivatives
DE19719621A1 (en) 1997-05-09 1998-11-12 Hoechst Ag Sulfonylaminocarboxylic acids
US6297239B1 (en) 1997-10-08 2001-10-02 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
SE9704272D0 (en) * 1997-11-21 1997-11-21 Astra Pharma Prod Novel Compounds
SE9704546D0 (en) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
SE9704545D0 (en) * 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
SE9704544D0 (en) * 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
JPH11318492A (en) * 1998-03-09 1999-11-24 Aisin Seiki Co Ltd Composition containing fluorogenic substrate
US6320078B1 (en) 1998-07-24 2001-11-20 Mitsui Chemicals, Inc. Method of producing benzamide derivatives
FR2783519B1 (en) 1998-09-23 2003-01-24 Sod Conseils Rech Applic NOVEL AMIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE19851184A1 (en) 1998-11-06 2000-05-11 Aventis Pharma Gmbh N-arylsulfonylamino acid omega amides
ES2249059T3 (en) 1998-12-16 2006-03-16 Bayer Healthcare Ag NEW BIFENYL COMPOUNDS AND BIFENYL ANALOGS AS INTEGRINE ANTAGONIST
KR100710091B1 (en) * 1999-04-09 2007-04-25 아스트라제네카 아베 Adamantane Derivatives
JP2003500387A (en) 1999-05-24 2003-01-07 シーオーアール セラピューティクス インコーポレイテッド Factor Xa inhibitors
SE9901875D0 (en) 1999-05-25 1999-05-25 Astra Pharma Prod Novel compounds
EP1088821A1 (en) 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Pharmaceutically active sulfonamide derivatives
MXPA02005102A (en) 1999-10-18 2003-09-25 Alexipharma Inc Retro anandamides, high affinity and stability cannabinoid receptor ligands.
SE9904505D0 (en) 1999-12-09 1999-12-09 Astra Pharma Prod Novel compounds
TWI258462B (en) 1999-12-17 2006-07-21 Astrazeneca Ab Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same
SE9904652D0 (en) * 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
SE9904738D0 (en) 1999-12-22 1999-12-22 Astra Pharma Prod Novel compounds
DE10005284A1 (en) 2000-02-07 2001-08-09 Bayer Ag 1-Amino-3-phenyl-uracil preparation in high yield, for use as agrochemical or intermediate, by aminating 3-phenyl-uracil with 2-aminooxysulfonyl-1,3,5-trimethylbenzene
GB0013737D0 (en) * 2000-06-07 2000-07-26 Astrazeneca Ab Novel compounds

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