CA2413624A1 - Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode - Google Patents

Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode Download PDF

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Publication number
CA2413624A1
CA2413624A1 CA002413624A CA2413624A CA2413624A1 CA 2413624 A1 CA2413624 A1 CA 2413624A1 CA 002413624 A CA002413624 A CA 002413624A CA 2413624 A CA2413624 A CA 2413624A CA 2413624 A1 CA2413624 A1 CA 2413624A1
Authority
CA
Canada
Prior art keywords
electrode
reservoir
polymeric material
applied area
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002413624A
Other languages
French (fr)
Other versions
CA2413624C (en
Inventor
Udayk Jain
Vilambi Nrk Reddy
Bruce M. Eliash
Kevin John Carey
Vitaly Falevich
Preston Keusch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vyteris Inc
Original Assignee
Vyteris, Inc.
Udayk Jain
Vilambi Nrk Reddy
Bruce M. Eliash
Kevin John Carey
Vitaly Falevich
Preston Keusch
Becton, Dickinson And Company
Drug Delivery Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vyteris, Inc., Udayk Jain, Vilambi Nrk Reddy, Bruce M. Eliash, Kevin John Carey, Vitaly Falevich, Preston Keusch, Becton, Dickinson And Company, Drug Delivery Technologies, Inc. filed Critical Vyteris, Inc.
Publication of CA2413624A1 publication Critical patent/CA2413624A1/en
Application granted granted Critical
Publication of CA2413624C publication Critical patent/CA2413624C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/0436—Material of the electrode

Abstract

A reservoir-electrode for an iontophoretic delivery device of the present invention includes an electrode; and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a substantially uniform concentration of an alkali metal chloride salt therein thereby substantially eliminating concentration gradients of the salt with respect to the electrode. The polymeric material has a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesive to an applied area of a patient's skin. The polymeric material has a cohesive strength, wherein a bond strength of an adhesive bond between the second surface of the polymeric material to the electrode is greater than the cohesive strength of the polymeric material and an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir-electrode from the applied area of the patient, substantially no polymeric material remains on the applied area and the reservoir remains substantially intact and adhesively adherent to the electrode.
CA002413624A 2000-06-30 2001-06-29 Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode Expired - Fee Related CA2413624C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/610,563 US6629968B1 (en) 2000-06-30 2000-06-30 Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode
US09/610,563 2000-06-30
PCT/US2001/020886 WO2002002182A2 (en) 2000-06-30 2001-06-29 Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system

Publications (2)

Publication Number Publication Date
CA2413624A1 true CA2413624A1 (en) 2002-01-10
CA2413624C CA2413624C (en) 2007-09-18

Family

ID=24445534

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002413624A Expired - Fee Related CA2413624C (en) 2000-06-30 2001-06-29 Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode

Country Status (8)

Country Link
US (2) US6629968B1 (en)
EP (1) EP1294439B1 (en)
JP (1) JP4024673B2 (en)
AT (1) ATE369891T1 (en)
AU (1) AU2001273104A1 (en)
CA (1) CA2413624C (en)
DE (1) DE60129965T2 (en)
WO (1) WO2002002182A2 (en)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6757560B1 (en) * 1999-04-09 2004-06-29 Novosis Pharma Ag Transdermal delivery system (TDS) with electrode network
JP4033382B2 (en) * 2002-04-08 2008-01-16 久光製薬株式会社 Insulin administration device
US7776600B2 (en) 2002-04-18 2010-08-17 Carnegie Mellon University Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids
WO2003088925A2 (en) 2002-04-18 2003-10-30 Carnegie Mellon University Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids
JP4089875B2 (en) * 2002-06-12 2008-05-28 共同印刷株式会社 Electrode device including a recess
JP3493359B1 (en) * 2003-03-20 2004-02-03 宣美 辛島 Iontophoretic therapy device
US7917205B2 (en) * 2003-03-20 2011-03-29 Nobuyoshi Karashima Iontophoresis-based medical device
ES2320892T3 (en) * 2003-03-31 2009-05-29 Alza Corporation ELECTROTRANSPORT DEVICE THAT HAS A DEPOSIT COVER WITH A FLEXIBLE DRIVING ELEMENT.
JPWO2005020967A1 (en) * 2003-08-29 2007-11-01 久光製薬株式会社 Electrical drug delivery formulation
JP4879754B2 (en) 2004-01-22 2012-02-22 リハブトロニクス インコーポレーテッド Method for carrying electrical current to body tissue via implanted non-active conductor
US20100016929A1 (en) * 2004-01-22 2010-01-21 Arthur Prochazka Method and system for controlled nerve ablation
US20050234516A1 (en) * 2004-02-16 2005-10-20 Gueret Jean-Louis H Treatment kit, composite structure, electric exciter, and cosmetic treatment method
FR2866240B1 (en) * 2004-02-16 2006-06-23 Oreal TREATMENT KIT COMPRISING A COMPOSITE STRUCTURE TO BE APPLIED TO THE SKIN AND AN ELECTRIC EXCITATOR
US20050228336A1 (en) * 2004-04-07 2005-10-13 Preston Keusch Electrically assisted lidocaine and epinephrine delivery device having extended shelf-stability
US20050228335A1 (en) * 2004-04-07 2005-10-13 Reddy Vilambi N Physical, structural, mechanical, electrical and electromechanical features for use in association with electrically assisted delivery devices and systems
WO2006015299A2 (en) * 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
JP4728631B2 (en) * 2004-11-30 2011-07-20 Ｔｔｉ・エルビュー株式会社 Iontophoresis device
US7590444B2 (en) * 2004-12-09 2009-09-15 Tti Ellebeau, Inc. Iontophoresis device
JP4731931B2 (en) * 2005-02-03 2011-07-27 Ｔｔｉ・エルビュー株式会社 Iontophoresis device
JP4793806B2 (en) * 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 Iontophoresis device
US8386029B2 (en) 2005-03-31 2013-02-26 Encore Medical Asset Corporation Apparatus for electrotherapy drug delivery with added impurities
US20070027426A1 (en) * 2005-06-24 2007-02-01 Transcutaneous Technologies Inc. Iontophoresis device to deliver active agents to biological interfaces
US8386030B2 (en) 2005-08-08 2013-02-26 Tti Ellebeau, Inc. Iontophoresis device
US8295922B2 (en) 2005-08-08 2012-10-23 Tti Ellebeau, Inc. Iontophoresis device
US20070088331A1 (en) * 2005-08-18 2007-04-19 Transcutaneous Technologies Inc. Method and apparatus for managing active agent usage, and active agent injecting device
JPWO2007032446A1 (en) 2005-09-15 2009-03-19 Ｔｔｉ・エルビュー株式会社 Rod iontophoresis device
WO2007041300A2 (en) * 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Iontophoresis method and apparatus for systemic delivery of active agents
WO2007041475A2 (en) * 2005-09-30 2007-04-12 Vyteris, Inc. Iontophoresis drug delivery formulation providing acceptable sensation and dermal anesthesia
US20070083147A1 (en) * 2005-09-30 2007-04-12 Transcutaneous Technologies Inc. Iontophoresis apparatus and method to deliver antibiotics to biological interfaces
US20070078434A1 (en) * 2005-09-30 2007-04-05 Vyteris, Inc. Indications For Local Transport of Anaesthetic Agents By Electrotransport Devices
WO2007041386A2 (en) * 2005-09-30 2007-04-12 Vyteris, Inc. Pulsatile delivery of gonadotropin-releasing hormone from a pre-loaded integrated electrotransport patch
US20070093743A1 (en) * 2005-09-30 2007-04-26 Vyteris, Inc. Iontophoresis Drug Delivery Device Providing Acceptable Depth and Duration of Dermal Anesthesia
CN101365433B (en) * 2005-11-14 2011-04-13 帝国制药株式会社 Iontophoresis preparation
US7848801B2 (en) 2005-12-30 2010-12-07 Tti Ellebeau, Inc. Iontophoretic systems, devices, and methods of delivery of active agents to biological interface
US8483820B2 (en) * 2006-10-05 2013-07-09 Bioness Inc. System and method for percutaneous delivery of electrical stimulation to a target body tissue
WO2008067409A2 (en) * 2006-11-28 2008-06-05 Polyplus Battery Company Protected lithium electrodes for electro-transport drug delivery
JP5383497B2 (en) 2006-12-01 2014-01-08 Ｔｔｉ・エルビュー株式会社 System and device for powering and / or controlling a device, for example a transdermal delivery device
JPWO2008087803A1 (en) * 2007-01-16 2010-05-06 国立大学法人北海道大学 Liposome preparation for iontophoresis encapsulating antioxidant components
US7844345B2 (en) * 2007-02-08 2010-11-30 Neuropace, Inc. Drug eluting lead systems
US7813811B2 (en) * 2007-02-08 2010-10-12 Neuropace, Inc. Refillable reservoir lead systems
US20080200969A1 (en) * 2007-02-16 2008-08-21 Thermage, Inc. Temperature sensing apparatus and methods for treatment devices used to deliver high frequency energy to tissue
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
WO2009006349A2 (en) * 2007-06-29 2009-01-08 Polyplus Battery Company Electrotransport devices, methods and drug electrode assemblies
EP2178598A4 (en) * 2007-08-17 2012-08-15 Isis Biopolymer Llc Iontophoretic drug delivery system
US9757554B2 (en) 2007-08-23 2017-09-12 Bioness Inc. System for transmitting electrical current to a bodily tissue
US8738137B2 (en) 2007-08-23 2014-05-27 Bioness Inc. System for transmitting electrical current to a bodily tissue
EP2180918B1 (en) * 2007-08-23 2017-07-12 Bioness Inc. Electrodes with a power source and with connectors for coupling to an external stimulator
US20090069740A1 (en) * 2007-09-07 2009-03-12 Polyplus Battery Company Protected donor electrodes for electro-transport drug delivery
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
US8900431B2 (en) 2008-08-27 2014-12-02 Edwards Lifesciences Corporation Analyte sensor
US20110306878A1 (en) 2009-02-26 2011-12-15 Liquidia Technologies, Inc. Interventional drug delivery system and associated methods
JP2012525943A (en) * 2009-05-08 2012-10-25 アイシス バイオポリマー，インク． Iontophoresis device with improved counter electrode
US20110092881A1 (en) * 2009-05-08 2011-04-21 Isis Biopolymer Inc. Iontophoretic device with contact sensor
WO2011002776A1 (en) * 2009-06-29 2011-01-06 Nitric Biotherapeutics, Inc. Pharmaceutical formulations for iontophoretic delivery of an immunomodulator
JP5463136B2 (en) 2009-12-22 2014-04-09 帝國製薬株式会社 Electrode device used for iontophoresis therapy
AU2011345942B2 (en) * 2010-12-22 2016-03-10 Teikoku Seiyaku Co., Ltd. Electrode pad for iontophoresis
US9610440B2 (en) * 2013-06-10 2017-04-04 Iontera, Inc Systems, devices, and methods for transdermal delivery
GB2524777A (en) * 2014-04-02 2015-10-07 Microarray Ltd Dressing comprising electrodes
CN104287714A (en) * 2014-11-10 2015-01-21 青岛柏恩鸿泰电子科技有限公司 Silver/ silver chloride powder electrode
WO2016142176A1 (en) * 2015-03-09 2016-09-15 Koninklijke Philips N.V. Iontophoretic device, arrangement and method
SG11201703913YA (en) * 2016-01-05 2017-08-30 Biosensor Laboratories Inc Iontophoresis Device For Drug Delivery And Method For Manufacturing The Same

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416274A (en) 1981-02-23 1983-11-22 Motion Control, Inc. Ion mobility limiting iontophoretic bioelectrode
JPS5810066A (en) * 1981-07-10 1983-01-20 株式会社アドバンス Plaster structure for ion tofuorese
CA1262564A (en) * 1983-09-01 1989-10-31 Minoru Sasaki Iontophoresis device
US5135477A (en) 1984-10-29 1992-08-04 Medtronic, Inc. Iontophoretic drug delivery
US4752285B1 (en) 1986-03-19 1995-08-22 Univ Utah Res Found Methods and apparatus for iontophoresis application of medicaments
US5496266A (en) * 1990-04-30 1996-03-05 Alza Corporation Device and method of iontophoretic drug delivery
US4989607A (en) * 1989-03-30 1991-02-05 Preston Keusch Highly conductive non-stringy adhesive hydrophilic gels and medical electrode assemblies manufactured therefrom
US5143071A (en) * 1989-03-30 1992-09-01 Nepera, Inc. Non-stringy adhesive hydrophilic gels
US5374241A (en) 1989-07-21 1994-12-20 Iomed, Inc. Electrodes for iontophoresis
US5328455A (en) * 1989-07-21 1994-07-12 Iomed, Inc. Rehydratable product and method of preparation thereof
US5084008A (en) * 1989-12-22 1992-01-28 Medtronic, Inc. Iontophoresis electrode
US5125894A (en) * 1990-03-30 1992-06-30 Alza Corporation Method and apparatus for controlled environment electrotransport
US5362308A (en) * 1990-09-25 1994-11-08 Rutgers, The State University Of New Jersey Disposable dosage unit for iontophoresis-facilitated transdermal delivery, related devices and processes
US5158537A (en) 1990-10-29 1992-10-27 Alza Corporation Iontophoretic delivery device and method of hydrating same
DE69109690T3 (en) 1990-10-29 1999-06-02 Alza Corp ELECTRODE FOR IONTOPHORETIC ADMINISTRATION OF MEDICINES AND METHOD FOR THE HYDRATION OF THE SAME.
ES2065181T3 (en) * 1991-03-11 1995-02-01 Alza Corp IONTOPHORETICAL SUPPLY DEVICE AND PROCEDURE FOR ITS MANUFACTURE.
US5405317A (en) * 1991-05-03 1995-04-11 Alza Corporation Iontophoretic delivery device
US5203768A (en) * 1991-07-24 1993-04-20 Alza Corporation Transdermal delivery device
US5464387A (en) * 1991-07-24 1995-11-07 Alza Corporation Transdermal delivery device
US5310404A (en) * 1992-06-01 1994-05-10 Alza Corporation Iontophoretic delivery device and method of hydrating same
JP2542792B2 (en) 1992-11-05 1996-10-09 ベクトン・ディッキンソン・アンド・カンパニー User-operated iontophoretic device
US6377847B1 (en) 1993-09-30 2002-04-23 Vyteris, Inc. Iontophoretic drug delivery device and reservoir and method of making same
AU2286995A (en) * 1994-04-08 1995-10-30 Alza Corporation Electrotransport system with ion exchange competitive ion capture
JPH08155041A (en) * 1994-12-05 1996-06-18 Advance Co Ltd New high-efficiency electrode system for iontophoresis
US5837281A (en) * 1995-03-17 1998-11-17 Takeda Chemical Industries, Ltd. Stabilized interface for iontophoresis
US5990179A (en) * 1995-04-28 1999-11-23 Alza Corporation Composition and method of enhancing electrotransport agent delivery
US5853383A (en) * 1995-05-03 1998-12-29 Alza Corporation Preparation for formulations for electrotransport drug delivery
US5983130A (en) * 1995-06-07 1999-11-09 Alza Corporation Electrotransport agent delivery method and apparatus
US5908400A (en) * 1996-06-20 1999-06-01 Hisamitsu Pharmaceutical Co., Inc. Device structure for iontophoresis
US6350259B1 (en) * 1996-09-30 2002-02-26 Vyteris, Inc. Selected drug delivery profiles using competing ions
FR2755372B1 (en) * 1996-11-07 1998-12-24 Elf Aquitaine IONOPHORESIS DEVICE COMPRISING AT LEAST ONE MEMBRANE ELECTRODE ASSEMBLY FOR THE TRANSCUTANEOUS ADMINISTRATION OF ACTIVE PRINCIPLES TO A SUBJECT
EP0941085B1 (en) 1996-11-14 2003-04-23 Alza Corporation Device for electrically assisted delivery of agents such as lidocaine and epinephrine
US6004577A (en) * 1997-08-12 1999-12-21 Murdock; Thomas O. Enhanced electrotransport of therapeutic agents having polybasic anionic counter ions
US5882677A (en) * 1997-09-30 1999-03-16 Becton Dickinson And Company Iontophoretic patch with hydrogel reservoir
US6295469B1 (en) * 1997-11-14 2001-09-25 Alza Corporation Formulation for electrically assisted delivery of lidocaine and epinephrine
US6496727B1 (en) * 2000-05-31 2002-12-17 Becton, Dickinson And Company Medicament-loaded transdermal reservoir and method for its formation

Also Published As

Publication number Publication date
JP2004501727A (en) 2004-01-22
EP1294439B1 (en) 2007-08-15
EP1294439A2 (en) 2003-03-26
DE60129965D1 (en) 2007-09-27
US20020062102A1 (en) 2002-05-23
WO2002002182A2 (en) 2002-01-10
JP4024673B2 (en) 2007-12-19
AU2001273104A1 (en) 2002-01-14
DE60129965T2 (en) 2008-05-15
US6635045B2 (en) 2003-10-21
WO2002002182A3 (en) 2002-06-27
US6629968B1 (en) 2003-10-07
ATE369891T1 (en) 2007-09-15
CA2413624C (en) 2007-09-18

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