CA2413758A1 - Implanted sensor processing system and method - Google Patents

Implanted sensor processing system and method Download PDF

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Publication number
CA2413758A1
CA2413758A1 CA002413758A CA2413758A CA2413758A1 CA 2413758 A1 CA2413758 A1 CA 2413758A1 CA 002413758 A CA002413758 A CA 002413758A CA 2413758 A CA2413758 A CA 2413758A CA 2413758 A1 CA2413758 A1 CA 2413758A1
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CA
Canada
Prior art keywords
coil
load
sensor
radiation
channel detector
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Granted
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CA002413758A
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French (fr)
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CA2413758C (en
Inventor
Jeffery C. Lesho
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Sensors for Medicine and Science Inc
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Individual
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Publication of CA2413758A1 publication Critical patent/CA2413758A1/en
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Publication of CA2413758C publication Critical patent/CA2413758C/en
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Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0031—Implanted circuitry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0204—Operational features of power management
    • A61B2560/0214—Operational features of power management of power generation or supply
    • A61B2560/0219—Operational features of power management of power generation or supply of externally powered implanted units

Abstract

A quantitative measurement system includes an external unit (101a) and an internal unit (102a) are provided for obtaining quantitative analyte measurements, such as within the body. In one example of an application of the system, the internal unit (102a) would be implanted either subcutaneously or otherwise within the body of a subject. The internal unit (102a) contains optoelectronics circuitry (102b), a component of which may be comprised of a fluorescence sensing device. The optoelectronics circuitry (102b) obtains quantitative measurement information and modifies a load (102c) as a function of the obtained information. The load (102c) in turn varies the amount of current through coil (102d), which is coupled to a coil (101f) of the external unit (101a). A demodulator (101b) detects the current variations induced in the external coil (101f) by the internal coil (102d) coupled thereto, and applies the detected signal to processing circuitry, such as a pulse counter (101c) and computer interface (101d), for processing the signal into computer-readable format for inputting to a computer (101e).

Claims (22)

1. Apparatus for retrieving information from a sensor device, comprising:
an internal sensor unit for taking quantitative analyte measurements, including a first coil forming part of a power supply for said sensor unit, a load coupled to said first coil, and a sensor circuit for modifying said load in accordance with sensor measurement information obtained by said sensor circuit;

an external unit including a second coil which is mutually inductively coupled to said first coil upon said second coil being placed within a predetermined proximal distance from said first coil, an oscillator for driving said second coil to induce a charging current in said first coil, and a detector for detecting variations in a load on said second coil induced by changes to said load in said internal sensor unit and for providing information signals corresponding to said load changes; and a processor for receiving and processing said information signals.
2. Apparatus according to claim 1, wherein said sensor circuit comprises an indicator element which emits radiation in proportion to levels of said analyte.
3. Apparatus according to claim 2, wherein said load comprises a photosensitive resistor which receives radiation from said indicator element.
4. Apparatus according to claim 2, wherein said sensor circuit further comprises a radiation source for emitting electromagnetic radiation which stimulates emission of radiation.
5. Apparatus according to claim 2, wherein said indicator element emits fluorescent radiation in proportion to levels of said analyte.
6. Apparatus according to claim 3, wherein said load comprises a photosensitive resistor which receives fluorescent radiation from said indicator element.
7. Apparatus according to claim 4, wherein said radiation source for emitting electromagnetic radiation stimulates emission of fluorescent radiation.
8. Apparatus according to claim 1, wherein said internal unit is implantable in the body of a mammal.
9. Apparatus according to claim 1, wherein said power supply further includes a charging capacitor which is charged by said charging current.
10. Apparatus according to claim 1, wherein said detector of said external unit includes an amplitude modulation (AM) demodulator for detecting changes in amplitude of a voltage waveform caused by changes in said load, said voltage waveform being inductively reflected into said second coil through said first coil.
11. Apparatus according to claim 10, wherein said external unit further includes a pulse counter for converting said detected changes in waveform amplitude into pulses suitable for being converted into computer-readable form.
12. Apparatus according to claim 11, wherein said processor includes a computer.
13. Apparatus according to claim 1, wherein said internal unit is ingestible in the body of a mammal.
14. Apparatus according to claim 1, wherein said internal unit is implantable in the body of a fish.
15. Apparatus according to claim 1, wherein said internal unit is implantable in the body of a plant.
16. Apparatus according to claim 1, wherein said sensor circuit comprises an indicator element which absorbs radiation in proportion to levels of said analyte.
17. A sensor device for detecting the presence or concentration of an analyte in a medium, comprising:

an enclosed sensor body having an outer surface surrounding said sensor body;
a radiation source in said sensor body which emits radiation within said sensor body;

an indicator element having an optical characteristic that is affected by the presence or concentration of an analyte, said indicator element being positioned on said sensor body to receive radiation that travels from said radiation source, and which transmits radiation into said sensor body;

a photosensitive element located in said sensor body and positioned to receive radiation within the sensor body from said indicator element; and an inductive element located in said sensor and coupled to said photosensitive element, said inductive element being adapted to receive from an external inductive element a magnetically induced electric current for supplying power to said sensor device, and being further adapted to induce in said external inductive element an electric current which changes as a function of the amount of radiation received by said photosensitive element.
18. Apparatus for retrieving information from a sensor device, comprising:
an internal sensor unit fox taking quantitative analyte measurements, including a first coil forming part of a power supply for said sensor unit, a load coupled to said first coil, and a sensor circuit for modifying said load in accordance with sensor measurement information obtained by said sensor circuit, said sensor circuit including a signal channel detector responsive to analyte measurement information, and a reference channel detector responsive to reference measurement information, outputs of said signal channel detector and said reference channel detector being combined in said sensor information for modifying said load;
an external unit including a second coil which is mutually inductively coupled to said first coil upon said second coil being placed within a predetermined proximal distance from said first coil, an oscillator for driving said second coil to induce a charging current in said first coil, and a detector for detecting variations in a load on said second coil induced by changes to said load in said internal sensor unit and for providing information signals corresponding to said load changes; and a processor for receiving and processing said information signals.
19. Apparatus according to claim 18, wherein said signal channel detector and reference channel detector are photodiodes.
20. Apparatus according to claim 19, wherein signal channel detector photodiode and said reference channel detector photodiode are conected in a cathode-to-cathode configuration.
21. Apparatus according to claim 18, wherein one of said signal channel detector and said reference channel detector produces an output determinative of a positive transition time of said load modification, and the other produces an output determinative of a negative transition time of said load modification, such that a time difference between a positive load duration and a negative load duration is indicative of analyte concentration as well as a difference between output said reference channel detector and output of said signal channel detector.
22. Apparatus according to claim 2, wherein said load comprises a photodiode, a comparator and a resistor operatively coupled with each other to provide a varying load as a function of analyte concentration.
CA2413758A 2000-06-29 2001-06-27 Implanted sensor processing system and method Expired - Lifetime CA2413758C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/605,706 US6400974B1 (en) 2000-06-29 2000-06-29 Implanted sensor processing system and method for processing implanted sensor output
US09/605,706 2000-06-29
PCT/US2001/020390 WO2002002005A1 (en) 2000-06-29 2001-06-27 Implanted sensor processing system and method

Publications (2)

Publication Number Publication Date
CA2413758A1 true CA2413758A1 (en) 2002-01-10
CA2413758C CA2413758C (en) 2011-04-05

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Family Applications (1)

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CA2413758A Expired - Lifetime CA2413758C (en) 2000-06-29 2001-06-27 Implanted sensor processing system and method

Country Status (13)

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US (1) US6400974B1 (en)
EP (2) EP1294276A1 (en)
JP (3) JP5033295B2 (en)
KR (2) KR100911887B1 (en)
CN (1) CN100369577C (en)
AU (2) AU2002216747B2 (en)
BR (1) BR0112049A (en)
CA (1) CA2413758C (en)
DK (1) DK2103250T3 (en)
HK (1) HK1135010A1 (en)
MX (1) MXPA03000138A (en)
TW (1) TW581670B (en)
WO (1) WO2002002005A1 (en)

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