CA2423524A1 - Topical anti-cancer compositions and methods of use thereof - Google Patents
Topical anti-cancer compositions and methods of use thereof Download PDFInfo
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- CA2423524A1 CA2423524A1 CA002423524A CA2423524A CA2423524A1 CA 2423524 A1 CA2423524 A1 CA 2423524A1 CA 002423524 A CA002423524 A CA 002423524A CA 2423524 A CA2423524 A CA 2423524A CA 2423524 A1 CA2423524 A1 CA 2423524A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/51—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Abstract
Described are skin-care compositions containing non denatured soy products and optionally other anti-cancer or anti-aging agents. The compositions can be applied topically to reduce the risk of UV-induced cutaneous tumors.
Claims
further comprises at least one sunscreen.
10. The method of claim 1, wherein said composition further comprises from about 1 to about 99% soy bean milk, from about 0.1 to about 20% emulsifier, and a preservative in an effective amount.
11. The method of claim 10 wherein said composition further comprises an anti-oxidant.
12. The method of claim 10, wherein said composition further composition further comprises an anti cancer agent.
13. The method claim 10, wherein said composition further comprises at least one agent selected from the group consisting of anti-oxidants, sunscreens, moisturizers, bleaching agents, depigmentation agents, darkening agents, surfactants, foaming agents, conditioners, humectants, fragrances, anti-aging agents, anti-inflammatory agents, and anti-cancer agents.
14. The method of claim 1, wherein said composition further comprises from about 0.1 to about 20% soy bean powder or soy milk powder, from about 0.1 to about 20%
emulsifier, and a preservative in an effective amount.
15. The method of claim 14, wherein said composition further comprises an anti-cancer agent.
16. The method of claim 14, wherein said composition further comprises an anti-oxidant.
17. The method of claim 14, wherein said composition further comprises at least one compound selected from the group consisting of anti-oxidants, sunscreens, moisturizers, bleaching agents, depigmentation agents, darkening agents, surfactants, foaming agents, conditioners, humectants, fragrances, anti-aging agents, anti-inflammatory agents, and anti-cancer agents.
18. A method for preventing and reducing the risk of skin cancer comprising topical application of at least one composition containing a non-denatured, soy product in an amount of from about 0.01-99% by weight in a carrier.
19. The method of claim 18, wherein said composition is applied at least once daily on a continuous basis.
20. The method of claim 18, wherein said composition is applied at least twice daily for at least eight weeks and at least once daily on a continuous basis thereafter.
21. The method of claim 18, wherein said soy product composition comprises 0.05-80% by weight and is applied for at least about four to about ten weeks followed by topical application of a composition comprising 0.01-20%
by weight of said soy product on a daily basis thereafter.
22. The method of claim 18, wherein said composition further comprises a cosmetically acceptable vehicle.
23. The method of claim 18, wherein said composition further comprises at least one anti-inflammatory agent.
24. The method of claim 18, wherein said composition further comprises at least one anti-cancer agent.
25. The method of claim 18, wherein said composition further comprises at least one anti-oxidant.
26. The method of claim 18, wherein said composition further comprises at least one sunscreen.
27. The method of claim 18, wherein said composition further comprises from about 1 to about 99% soy bean milk, from about 0.1 to about 20% emulsifier, and a preservative in an effective amount.
28. The method of claim 27, wherein said composition further comprises an anti-oxidant.
29. The method of claim 27, wherein said compositions further comprises an anti-cancer agent.
30. The method of claim 27, wherein said composition further comprises at least one compound selected from the group consisting of anti-oxidants, sunscreens, moisturizers, bleaching agents, depigmentation agents, darkening agents, surfactants, foaming agents, conditioners, humectants, fragrances, anti-aging agents, anti-inflammatory agents, and anti-cancer agents.
31. The method of claim 18, wherein said composition further comprises from about 0.1 to about 20% soy bean powder or soy milk powder, from about 0.1 to about 20%
emulsifier, and a preservative in an effective amount.
32. The method of claim 31, wherein said composition further comprisese an anti-oxidant.
33. The method of claim 31, wherein said composition further comprises an anti-cancer agent.
34. The method of claim 31, wherein said composition further comprises at least one compound selected from the group consisting of anti-oxidants, sunscreens,.
moisturizers, bleaching agents, depigmentation agents, darkening agents, surfactants, foaming agents, conditioners, humectants, fragrances, anti-aging agents, anti-inflammatory agents, and anti-cancer agents.
35. A method of inhibiting the progression of a cutaneous tumor comprising topical application of at least one composition containing a non-denatured, soybean trypsin inhibitor in an amount of from about 0.01-99% by weight.
36. The method of claim 35, wherein said composition is applied at least once daily on a continuous basis.
37. The method of claim 35, wherein said composition is applied at least twice daily for at least eight weeks and at least once daily on a continuous basis thereafter.
38. The method of claim 35, wherein said composition comprises 0.1-10% by weight of said non denatured soybean trypsin inhibitor and is applied for at least about four to about ten weeks followed by topical application of a composition comprising a non-denatured soybean trypsin inhibitor at 0.01-10% by weight of said soybean trypsin inhibitor on a daily basis thereafter.
39. The method of claim 35, wherein said non-denatured soybean trypsin inhibitor is contained within liposomes suspended in a cosmetically acceptable carrier.
40. The method. of claim 38, wherein said non-denatured soybean trypsin inhibitor is contained within in liposomes suspended in a cosmetically acceptable carrier.
41. The method of claim 35, wherein said composition further comprises a cosmetically acceptable vehicle.
42. The method of claim 35, wherein said composition further comprises at least one anti-inflammatory agent.
43. The method of claim 35 wherein said composition further comprises at least one anti-cancer agent.
44. The method of claim 35, wherein said composition further comprises at least one anti-oxidant.
45. The method of claim 35, wherein said composition further comprises at least one sunscreen.
46. The method of claim 35, wherein said composition further comprises from about 0.01 to about 99% soy bean trypsin inhibitor, from about 0.1 to about 20%
emulsifier, and a preservative in an effective amount.
47. The method of claim 46, wherein said composition further comprises an anti-oxidant.
48. The method of claim 46, wherein said composition further comprises an anti-cancer agent.
49. The method of claim 46, wherein said composition further comprises at least one compound selected from the group consisting of anti-oxidants; sunscreens, moisturizers, bleaching agents, depigmentation agents, darkening agents, surfactants, foaming agents, conditioners, humectants, fragrances, anti-aging agents, anti-inflammatory agents, and anti-cancer agents.
10. The method of claim 1, wherein said composition further comprises from about 1 to about 99% soy bean milk, from about 0.1 to about 20% emulsifier, and a preservative in an effective amount.
11. The method of claim 10 wherein said composition further comprises an anti-oxidant.
12. The method of claim 10, wherein said composition further composition further comprises an anti cancer agent.
13. The method claim 10, wherein said composition further comprises at least one agent selected from the group consisting of anti-oxidants, sunscreens, moisturizers, bleaching agents, depigmentation agents, darkening agents, surfactants, foaming agents, conditioners, humectants, fragrances, anti-aging agents, anti-inflammatory agents, and anti-cancer agents.
14. The method of claim 1, wherein said composition further comprises from about 0.1 to about 20% soy bean powder or soy milk powder, from about 0.1 to about 20%
emulsifier, and a preservative in an effective amount.
15. The method of claim 14, wherein said composition further comprises an anti-cancer agent.
16. The method of claim 14, wherein said composition further comprises an anti-oxidant.
17. The method of claim 14, wherein said composition further comprises at least one compound selected from the group consisting of anti-oxidants, sunscreens, moisturizers, bleaching agents, depigmentation agents, darkening agents, surfactants, foaming agents, conditioners, humectants, fragrances, anti-aging agents, anti-inflammatory agents, and anti-cancer agents.
18. A method for preventing and reducing the risk of skin cancer comprising topical application of at least one composition containing a non-denatured, soy product in an amount of from about 0.01-99% by weight in a carrier.
19. The method of claim 18, wherein said composition is applied at least once daily on a continuous basis.
20. The method of claim 18, wherein said composition is applied at least twice daily for at least eight weeks and at least once daily on a continuous basis thereafter.
21. The method of claim 18, wherein said soy product composition comprises 0.05-80% by weight and is applied for at least about four to about ten weeks followed by topical application of a composition comprising 0.01-20%
by weight of said soy product on a daily basis thereafter.
22. The method of claim 18, wherein said composition further comprises a cosmetically acceptable vehicle.
23. The method of claim 18, wherein said composition further comprises at least one anti-inflammatory agent.
24. The method of claim 18, wherein said composition further comprises at least one anti-cancer agent.
25. The method of claim 18, wherein said composition further comprises at least one anti-oxidant.
26. The method of claim 18, wherein said composition further comprises at least one sunscreen.
27. The method of claim 18, wherein said composition further comprises from about 1 to about 99% soy bean milk, from about 0.1 to about 20% emulsifier, and a preservative in an effective amount.
28. The method of claim 27, wherein said composition further comprises an anti-oxidant.
29. The method of claim 27, wherein said compositions further comprises an anti-cancer agent.
30. The method of claim 27, wherein said composition further comprises at least one compound selected from the group consisting of anti-oxidants, sunscreens, moisturizers, bleaching agents, depigmentation agents, darkening agents, surfactants, foaming agents, conditioners, humectants, fragrances, anti-aging agents, anti-inflammatory agents, and anti-cancer agents.
31. The method of claim 18, wherein said composition further comprises from about 0.1 to about 20% soy bean powder or soy milk powder, from about 0.1 to about 20%
emulsifier, and a preservative in an effective amount.
32. The method of claim 31, wherein said composition further comprisese an anti-oxidant.
33. The method of claim 31, wherein said composition further comprises an anti-cancer agent.
34. The method of claim 31, wherein said composition further comprises at least one compound selected from the group consisting of anti-oxidants, sunscreens,.
moisturizers, bleaching agents, depigmentation agents, darkening agents, surfactants, foaming agents, conditioners, humectants, fragrances, anti-aging agents, anti-inflammatory agents, and anti-cancer agents.
35. A method of inhibiting the progression of a cutaneous tumor comprising topical application of at least one composition containing a non-denatured, soybean trypsin inhibitor in an amount of from about 0.01-99% by weight.
36. The method of claim 35, wherein said composition is applied at least once daily on a continuous basis.
37. The method of claim 35, wherein said composition is applied at least twice daily for at least eight weeks and at least once daily on a continuous basis thereafter.
38. The method of claim 35, wherein said composition comprises 0.1-10% by weight of said non denatured soybean trypsin inhibitor and is applied for at least about four to about ten weeks followed by topical application of a composition comprising a non-denatured soybean trypsin inhibitor at 0.01-10% by weight of said soybean trypsin inhibitor on a daily basis thereafter.
39. The method of claim 35, wherein said non-denatured soybean trypsin inhibitor is contained within liposomes suspended in a cosmetically acceptable carrier.
40. The method. of claim 38, wherein said non-denatured soybean trypsin inhibitor is contained within in liposomes suspended in a cosmetically acceptable carrier.
41. The method of claim 35, wherein said composition further comprises a cosmetically acceptable vehicle.
42. The method of claim 35, wherein said composition further comprises at least one anti-inflammatory agent.
43. The method of claim 35 wherein said composition further comprises at least one anti-cancer agent.
44. The method of claim 35, wherein said composition further comprises at least one anti-oxidant.
45. The method of claim 35, wherein said composition further comprises at least one sunscreen.
46. The method of claim 35, wherein said composition further comprises from about 0.01 to about 99% soy bean trypsin inhibitor, from about 0.1 to about 20%
emulsifier, and a preservative in an effective amount.
47. The method of claim 46, wherein said composition further comprises an anti-oxidant.
48. The method of claim 46, wherein said composition further comprises an anti-cancer agent.
49. The method of claim 46, wherein said composition further comprises at least one compound selected from the group consisting of anti-oxidants; sunscreens, moisturizers, bleaching agents, depigmentation agents, darkening agents, surfactants, foaming agents, conditioners, humectants, fragrances, anti-aging agents, anti-inflammatory agents, and anti-cancer agents.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/108,248 | 2002-03-27 | ||
US10/108,248 US7309688B2 (en) | 2000-10-27 | 2002-03-27 | Topical anti-cancer compositions and methods of use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2423524A1 true CA2423524A1 (en) | 2003-09-27 |
CA2423524C CA2423524C (en) | 2011-05-10 |
Family
ID=27804381
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2423524A Expired - Fee Related CA2423524C (en) | 2002-03-27 | 2003-03-25 | Topical anti-cancer compositions and methods of use thereof |
Country Status (5)
Country | Link |
---|---|
US (3) | US7309688B2 (en) |
EP (1) | EP1348441B1 (en) |
BR (1) | BR0300830A (en) |
CA (1) | CA2423524C (en) |
DE (2) | DE03251884T1 (en) |
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-
2002
- 2002-03-27 US US10/108,248 patent/US7309688B2/en not_active Expired - Fee Related
-
2003
- 2003-03-25 CA CA2423524A patent/CA2423524C/en not_active Expired - Fee Related
- 2003-03-26 EP EP03251884A patent/EP1348441B1/en not_active Expired - Lifetime
- 2003-03-26 DE DE03251884T patent/DE03251884T1/en active Pending
- 2003-03-26 DE DE60306565T patent/DE60306565T2/en not_active Expired - Lifetime
- 2003-03-27 BR BR0300830-4A patent/BR0300830A/en not_active IP Right Cessation
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2004
- 2004-07-06 US US10/885,324 patent/US7879823B2/en not_active Expired - Fee Related
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2005
- 2005-04-07 US US11/100,905 patent/US20050244523A1/en not_active Abandoned
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US7879823B2 (en) | 2011-02-01 |
EP1348441B1 (en) | 2006-07-05 |
BR0300830A (en) | 2004-08-17 |
US20050244523A1 (en) | 2005-11-03 |
DE03251884T1 (en) | 2004-09-30 |
US7309688B2 (en) | 2007-12-18 |
CA2423524C (en) | 2011-05-10 |
US20040247713A1 (en) | 2004-12-09 |
DE60306565T2 (en) | 2007-07-05 |
EP1348441A1 (en) | 2003-10-01 |
DE60306565D1 (en) | 2006-08-17 |
US20030064049A1 (en) | 2003-04-03 |
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