CA2425337A1 - Optical sensor for in situ measurement of analytes - Google Patents
Optical sensor for in situ measurement of analytes Download PDFInfo
- Publication number
- CA2425337A1 CA2425337A1 CA002425337A CA2425337A CA2425337A1 CA 2425337 A1 CA2425337 A1 CA 2425337A1 CA 002425337 A CA002425337 A CA 002425337A CA 2425337 A CA2425337 A CA 2425337A CA 2425337 A1 CA2425337 A1 CA 2425337A1
- Authority
- CA
- Canada
- Prior art keywords
- assay
- sensor
- skin
- analyte
- components
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/685—Microneedles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
Abstract
An implantable sensor for use in the detection or quantitative measurement of an analyte in subcutaneous fluid, the sensor being biodegradable or hydrolysable in vivo. The sensor incorporates an assay for the analyte, the readout of which is a detectable or measurement optical signal which can, when the sensor is in operation in a subcutaneous location, be interrogated transcutaneously by external optical means.
Claims (17)
1. An assay implantation apparatus comprising a sensor for the in vivo measurement of an analyte and means for implanting said sensor within an upper layer of the skin from which it is naturally ejected over time by growth of the skin and progressive replacement of the outer layer of the skin.
2. Apparatus as claimed in Claim 1, wherein said implantation means comprises at least one injection needle having a length penetrable into the skin of no more than 200 µm.
3. Apparatus as claimed in Claim 1, comprising means for projecting said sensor into the skin to penetrate to the required depth within the skin.
4. Apparatus as claimed in any one of Claims 1 to 3, wherein said sensor comprises a multitude of micro-particles, each comprising an assay for said analyte, said assay producing a readout upon interrogation which readout is an optical signal which is detectable or measurable transcutaneously by external optical means.
5. Apparatus as claimed in any preceding claim, wherein said assay is a binding assay, the readout of which is a detectable or measurable optical signal.
6. Apparatus as claimed in Claim 5, wherein said binding assay is a competitive binding assay the components of which include an analyte binding agent and an analyte analog.
7. Apparatus as claimed in Claim 6, wherein said analyte analog is labelled with a first chromophore and said analyte binding agent is labelled with a second chromophore, the emission spectrum of said first chromophore overlapping with the absorption spectrum of said second chromophore.
8. Apparatus as claimed in Claim 5 or Claim 6, wherein the binding agent is an antibody, an Fab fragment, a lectin, a hormone receptor, a drug receptor, an aptamer or a molecularly-imprinted polymer.
9. Apparatus as claimed in any one of Claims 5 to 8, wherein said detectable or measurable optical signal is generated by fluorescence resonance energy transfer, fluorescence polarisation, fluorescence quenching, phosphorescence, luminescence enhancement, luminescence quenching, diffraction or plasmon resonance.
10. Apparatus as claimed in anyone of Claims 1 to 9, wherein the sensor comprises a matrix material, the components of said assay being suspended in said matrix material.
11. Apparatus as claimed in any preceding claim, wherein said sensor comprises solid microparticles and the components of said assay are uniformly dispersed in said solid microparticles.
12. Apparatus as claimed in any one of Claims 1 to 10, wherein said sensor comprises hollow microparticles and the components of said assay are encapsulated inside said hollow microparticles.
13. Apparatus as claimed in any one of Claims 1 to 9, wherein said sensor comprises a plurality of liposomes, the components of said assay being encapsulated inside said liposomes.
14. Apparatus as claimed in any one of Claims 1 to 9, wherein said sensor comprises a plurality of empty erythrocytes which have been loaded with the components of said assay.
15. An analytical system for the detection or quantitative measurement of an analyte in cutaneous fluid, which analytical system comprises, assay implantation apparatus as claimed in any one of the preceding claims together with optical means suitable for the transcutaneous interrogation of said sensor.
16. A method for in vivo assay of an analyte comprising placing a sensor within an upper layer of the skin from which it is naturally ejected over time by growth of the skin and progressive replacement of the outer layer of the skin.
17. A method as claimed in Claim 16, wherein the sensor is placed below the stratum corneum and within the epidermis.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0025147.0A GB0025147D0 (en) | 2000-10-13 | 2000-10-13 | Optical sensor for in situ measurement of analytes |
GB0025147.0 | 2000-10-13 | ||
PCT/EP2001/011822 WO2002030275A1 (en) | 2000-10-13 | 2001-10-12 | Optical sensor for in situ measurement of analytes |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2425337A1 true CA2425337A1 (en) | 2002-04-18 |
CA2425337C CA2425337C (en) | 2012-01-10 |
Family
ID=9901242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2425337A Expired - Lifetime CA2425337C (en) | 2000-10-13 | 2001-10-12 | Optical sensor for in situ measurement of analytes |
Country Status (15)
Country | Link |
---|---|
US (1) | US6671527B2 (en) |
EP (1) | EP1324691B1 (en) |
JP (1) | JP3873023B2 (en) |
AT (1) | ATE325575T1 (en) |
AU (2) | AU1401602A (en) |
CA (1) | CA2425337C (en) |
CY (1) | CY1105129T1 (en) |
DE (1) | DE60119556T2 (en) |
DK (1) | DK1324691T3 (en) |
ES (1) | ES2263671T3 (en) |
GB (1) | GB0025147D0 (en) |
NO (1) | NO334509B1 (en) |
NZ (1) | NZ525567A (en) |
PT (1) | PT1324691E (en) |
WO (1) | WO2002030275A1 (en) |
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WO2002030275A1 (en) | 2002-04-18 |
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DE60119556T2 (en) | 2007-01-25 |
AU2002214016B2 (en) | 2005-06-16 |
JP2004510527A (en) | 2004-04-08 |
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