CA2430499A1 - Injection systems - Google Patents

Injection systems Download PDF

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Publication number
CA2430499A1
CA2430499A1 CA002430499A CA2430499A CA2430499A1 CA 2430499 A1 CA2430499 A1 CA 2430499A1 CA 002430499 A CA002430499 A CA 002430499A CA 2430499 A CA2430499 A CA 2430499A CA 2430499 A1 CA2430499 A1 CA 2430499A1
Authority
CA
Canada
Prior art keywords
cavity
injector
charge
movable member
injection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002430499A
Other languages
French (fr)
Other versions
CA2430499C (en
Inventor
Robert R. Gonnelli
David Lipson
Vasu Nishtala
Ciro Dimeglio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Valeritas Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2430499A1 publication Critical patent/CA2430499A1/en
Application granted granted Critical
Publication of CA2430499C publication Critical patent/CA2430499C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2046—Media being expelled from injector by gas generation, e.g. explosive charge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2459—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/48—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for varying, regulating, indicating or limiting injection pressure
    • A61M5/484—Regulating injection pressure

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)

Abstract

Injection systems (50) and devices (52, 54) that can be used in injection systems are disclosed.

Claims (68)

1. An injection system, comprising:
an injector defining a first cavity in fluid communication with an orifice configured for needleless injection; and a housing inside the injector and defining a second cavity, the housing different than the injector, wherein the injection system is configured to transfer a fluid from the second cavity to the first cavity.
2. The system of claim 1, wherein the injector is formed of a first material, and the housing is formed of a second material different than the first material.
3. The system of claim 2, wherein the first material comprises a polymer.
4. The system of claim 2, wherein the second material comprises a glass.
5. The system of claim 1, further comprising a first movable member between the first cavity and the second cavity.
6. The system of claim 5, wherein the first movable member defines a lumen.
7. The system of claim 5, further comprising a second movable member between the first movable member and the second cavity.
8. The system of claim 7, wherein the first movable member is configured to engage with the second movable member such that the first cavity is in fluid communication with the second cavity.
9. The system of claim 5, wherein the first movable member is configured to be substantially stationary until the first movable member is moved by a propellant of the injection system.
10. The system of claim 5, wherein the first movable member comprises a tab configured to separate from the first movable member at a predetermined force.
11. The system of claim 10, wherein the tab is engaged with the injector.
12. The system of claim 1, wherein the injector and the housing are substantially coaxial.
13. The system of claim 1, wherein the second cavity is defined by the housing and two movable members.
14. The system of claim 1, further comprising an injector cap connectable to the injector, the injector cap configured to move distally to transfer the fluid from the second cavity to the first cavity.
15. The system of claim 14, wherein the injector cap is connectable to the injector by a threaded connection.
16. The system of claim 1, further comprising a charge cup in the injector.
17. The system of claim 16, further comprising a charge in the charge cup.
18. The system of claim 17, wherein the charge comprises at least two discrete materials.
19. The system of claim 18, wherein the at least two discrete materials have different combustion characteristics.
20. The system of claim 1, wherein the second cavity is defined by the housing and a movable member.
21. The system of claim 20, wherein the movable member is formed of two different materials
22. The system of claim 20, wherein the movable member comprises a rubber.
23. A method, comprising:
providing an injection system, comprising:
an injector defining a first cavity in fluid communication with an orifice configured for needleless injection; and a housing inside the injector and defining a second cavity, the housing different than the injector; and reducing the volume of the second cavity to transfer a fluid from the second cavity to the first cavity.
24. The method of claim 23, further comprising flowing the fluid through a movable member between the first and second cavities.
25. The method of claim 23, further comprising piercing a member between the first and second cavities.
26. The method of claim 23, wherein the injection system further comprises an injector cap connectable to the injector, and reducing the volume comprises moving the injector cap toward the orifice.
27. The method of claim 26, wherein moving the injector cap comprises twisting the injector cap.
28. The method of claim 23, further comprising moving the fluid through the orifice charge.
29. The method of claim 28, wherein the charge comprises at least two discrete materials.
30. The method of claim 29, wherein the at least two discrete materials have different combustion characteristics.
31. An injection system, comprising:
an injector defining a first cavity in fluid communication with an orifice configured for needleless injection;
a movable member in the first cavity, the movable member defining a second cavity; and a charge in the second cavity.
32. The system of claim 31, wherein the second cavity is at a proximal end of the movable member.
33. The system of claim 31, further comprising an electrically conductive member extending at least partially across the charge, the electrically conductive member capable of being in electrical communication with a power source.
34. The system of claim 31, further comprising a power unit connectable to the injector.
35. The system of claim 34, wherein the power unit comprises a battery.
36. The system of claim 31, further comprising a membrane at least partially extending across an opening of the second cavity.
37. The system of claim 31, further comprising a first electrically conductive portion connected to the movable member.
38. The system of claim 37, further comprising a second electrically conductive portion extending through the injector, the second electrically conductive portion in electrical communication with the first electrically conductive portion and capable of being in electrical communication with a power source.
39. The system of claim 31, wherein the charge comprises at least two discrete materials.
40. The system of claim 39, wherein the at least two discrete materials have different combustion characteristics.
41. The system of claim 31, wherein at least a portion of the injector is disposable.
42. The system of claim 34, wherein the power unit is reusable.
43. The system of claim 31, wherein the injector comprises a needleless injector.
44. The system of claim 31, wherein the moveable member comprises a piston.
45. A method of injection, comprising:
activating a charge in a movable member disposed in an injector defining an orifice configured for needleless injection.
46. The method of claim 45, wherein activating the charge includes flowing electrical current through the charge.
47. The method of claim 45, wherein the charge is disposed in a cavity defined by the movable member.
48. The method of claim 47, wherein the cavity is formed at a proximal end of the movable member.
49. The method of claim 45, wherein the charge comprises at least two discrete materials.
50. The method of claim 49, wherein the at least two discrete materials have different combustion characteristics.
51. An injection device, comprising:
an injector defining a first cavity and an orifice;
a movable member in the first cavity;
a housing defining a second cavity proximal of the movable member; and a charge in the second cavity, the charge comprising:
at least two discrete materials.
52. The device of claim 51, wherein the discrete materials have different combustion characteristics.
53. The device of claim 51, wherein the charge comprises at least two layers of materials.
54. The device of claim 53, wherein the at least two layers are adjacent each other.
55. The device of claim 51, wherein the charge comprises at least one trigger.
56. The device of claim 55, wherein the charge comprises at least one propellant.
57. The device of claim 56, wherein the charge comprises at least one passive decay material.
58. The device of claim 51, wherein the charge comprises at least one propellant.
59. The device of claim 51, wherein the charge comprises at least one passive decay material.
60. The device of claim 51, further comprising an electrically conductive member at least partially extending across the charge.
61. The device of claim 51, wherein the movable member and the housing are integrally formed.
62. The device of claim 51, wherein the device is configured for needleless injection.
63. The device of claim 51, wherein the device comprises a needleless injector.
64. The device of claim 51, wherein the charge is electrically activated.
65. A method, comprising:
igniting a charge in an injector having an orifice so that a fluid in a cavity in the injector is ejected out of the cavity, wherein the charge comprises at least two discrete materials.
66. The method of claim 65, wherein the injector orifice is configured for needleless injection.
67. The method of claim 65, wherein the injector comprises a needleless injector.
68. The method of claim 65, further comprising selecting the at least two discrete materials so that the fluid is ejected from the cavity in a predetermined fashion.
CA2430499A 2000-11-30 2001-11-30 Injection systems Expired - Fee Related CA2430499C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US25042500P 2000-11-30 2000-11-30
US25053700P 2000-11-30 2000-11-30
US25041000P 2000-11-30 2000-11-30
US25057300P 2000-11-30 2000-11-30
US60/250,410 2000-11-30
US60/250,573 2000-11-30
US60/250,425 2000-11-30
US60/250,537 2000-11-30
PCT/US2001/046029 WO2002051470A2 (en) 2000-11-30 2001-11-30 Injection systems

Publications (2)

Publication Number Publication Date
CA2430499A1 true CA2430499A1 (en) 2002-07-04
CA2430499C CA2430499C (en) 2012-05-22

Family

ID=27500354

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2430499A Expired - Fee Related CA2430499C (en) 2000-11-30 2001-11-30 Injection systems

Country Status (6)

Country Link
US (4) US7931614B2 (en)
EP (1) EP1339442A4 (en)
JP (4) JP4434583B2 (en)
KR (1) KR20030071780A (en)
CA (1) CA2430499C (en)
WO (1) WO2002051470A2 (en)

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