CA2430652C

CA2430652C - Proximal actuation handle for a biopsy forceps instrument having irrigation and aspiration capabilities

Info

Publication number: CA2430652C
Application number: CA002430652A
Authority: CA
Inventors: Juergen Andrew Kortenbach; Vincent Turturro
Original assignee: Symbiosis Corp
Current assignee: Boston Scientific Miami Corp
Priority date: 1997-02-03
Filing date: 1998-02-03
Publication date: 2005-03-29
Anticipated expiration: 2018-02-03
Also published as: JP3517247B2; EP1419740A2; EP0966229A1; CA2279195C; EP1419740A3; EP0966229B1; CA2430652A1; US7833167B2; CA2279195A1; AU6258098A; US20030073928A1; US20070270709A1; DE69827773T2; JP2000516832A; WO1998033436A1; DE69841601D1; US6544194B1; US6832990B2; EP1419740B1; US20040243024A1

Abstract

A biopsy forceps instrument is provided having a proximal actuation handle, a flexible multi-lumen tubular member, at least one control member extending through a lumen, an irrigation means, an aspiration means, and a distal assembly. The proximal actuation handle includes a shaft and a spool slidably mounted on the shaft. The actuation handle is coupled to the proximal ends of both the flexible tubular member and the control member. Lumens of the tubular member form irrigation and aspiration conduits. The distal assembly includes a hollow jaw cup coupled to the aspiration conduit and a hollow movable jaw coupled adjacent the irrigation conduit. The movable jaw is coupled to the control member, such that actuation of the actuation handle moves the movable jaw relative to the jaw cup. Moving the hollow jaws into a closed position provides a substantially fluidtight coupling between the irrigation and aspiration conduits. The actuation handle is also provided with an assembly to control irrigation to and aspiration from the distal assembly. A proximal sample chamber having a removable screen is provided for filtering tissue samples aspirated from the distal assembly. The jaws are activated to cut a tissue sample and the irrigation and aspiration means are activated to move the sample into the sample chamber for retrieving the sample without removing the instrument from a patient.

Description

'6 X22-499 PROXIMAL ACTUATION HANDhE FOR A BIOPSY FORCEPS INSTRUI~tENT
RAVING IRRIGATION AND ASPIRATION CAPABILITIES
BACKGROUND OF ~ Ti~iE INVE~1TION
1. Field of the invention This invention relates broadly to endosc:opic surgical instruments. More particularly, this invention relates to an actuation handle for an endoscopic biopsy forceps instrument with means for facilitating sample removal without withdrawal of the biopsy forceps instrument from an endoscope.

2. State of the Art Endoscopic biopsy procedures are typically performed with an endoscope and an endoscopic 'biopsy forceps de-~rice cbioptome) .
The endoscope i.s a long flexible tube carrying fiber optics and having a narrow lumen through which the bi~optome is inserted.
The bioptome typically includes a long flexible coilwhaving a pair of opposed jaws at the distal end and manual actuation means at the proximal end. Manipulation of the actuation means opens and closes the jaws. During~a biopsy tissue 'sampling operation, the sur.g.eon guilders the endoscope to the biopsy site while viewing the biopsy site through the :Fiber optics of the endoscope. T.he bi.optome is- inserted through the narrow lumen of the endoscope until the opposed jaws arrive at~the biopsy site.
While viewing the biopsy site through the fiber. optics of ttie endoscope, the swrgeon :positions' the yaws °arourid a tissue to be sampled and manipulates the actuationoiaeans so~that the jaws close around ''the tissue. A sample ~of 'the tissue is 'then cut and/or torn away from the biopsy site while it is ~t~rapped fV~ 98133436 PCTIUS98I0183~' ' p2_ between the jaws of the bioptome. Keeping t:he jaws closed, the surgeon withdraws the bioptome from the endoscope and then opens the jaws to collect the biopsy tissue sample.
A biopsy tissue sampling procedure often requires the.
taking of several tissue samples either from the same or from different biopsy sites. Unfortunately, most bioptomes are limited to taking a single tissue sample, after which the device must be withdrawn from the endoscope and the tissue collected before the device can be used again to take a se<:ond tissue sample. Several attempts have been made to provide an instrument which will allow the taking of several tissue samples before the instrument must be withdrawn and the samples collected. Problems in providing sLich an instrument include the extremely small size required by the narrow lumen of the endoscope and the fact that the instrument must be flexible in order to be inserted through the lumen of the endoscope. Thus, several known multiple sample biopsy instruments are precluded from use with an endoscope because of their size and rigidity.
These include the '°punch and suction type" :instruments disclosed in U.S. Patents No. 3,989,033 to Halpern et al. and No.
4,522,206 to Whipple et a1. F3oth of these devices have a hollow tube with a punch at the distal end and a vacuum source coupled to the proximal end. A tissue sample is cut with the punch anal suctioned away from the biopsy site through the hollow tube. It is generally recognized, however, that dry suctioning tissue samples (i.e., without the use of an irrigating fluid) through a long narrow flexible bioptome is virtually impossible.
Efforts have been made to provide multiple sampling ability to an instrument which must traverse the narrow lumen of an endoscope. These efforts have concentrated on providing a cylindrical atorage space at the distal endl of the instrument wherein several tissue samples can be accurrmlated before the instrument is~withdrawn from the endoscope. U.;5. Patent No.
4,651,753 to Lifton, for example, discloses a rigid cylindrical 5~.9~ST1TUTE ShtEET (Rt)LE 2fi) ., . ,._.i WO 98133430 3'G"fli1S9810 member attached to the distal end of ~ first flexible tube. The cylindrical member has a lateral opening and a concentric cylindrical knife blade is slidably mounted within the cylindrical member. A second flexible tuber concentric to the first tube is coupled to the knife blade for moving the knife blade relative to the lateral opening in the cylindrical membero A third flexible tube having a plunger tip is mounted within the second flexible tube and a vacuum source (a syringe) is coupled to the proximal end of the third tube. A tissue sample is taken by bringing the lateral opening of the cylindrical member upon the biopsy site, applying vacuum with the syringe to draw tissue into th~=_ lateral opening, and pushing the second flexible tube forward to move the knife blade across the lateral opening. A
tissue sample is thereby cut and trapped inside the cylindrical knife within the cylindrical member. The third flexible tube is then pushed forward moving its plunger end against the tissue sample and pushing it forward into a cylindrical storage space at the distal end of the cylindrical member. Approximately six samples can be stored in the cylindrical member, of ter which the instrument is withdrawn from the endoscope. A distal plug on the cylindrical member is removed and the six samples are collected by pushing the third tube so that its plunger end ejects the samples.
The device of the Lifton patent suffers from several recognizable drawbacks. First, it is often difficult tolobtain a tissue sample laterally of the device. Second, in order to expedite the obtaining of a lateral sample, a syringe is used to help draw the tissue into the lateral opening. However, this causes what was once a two-step procedure (position and cut), to become a three-step procedure (position, suction, cut). In addition, the.use of a syringe requires an additional hand.
ThirdP the Lifton patent adds a fourth step to the biopsy procedure by requiring that the tissue sample be pushed into the storage space: ,Thus, in all, the Lifton patent requires substantial effort on the part of the surgeon and an assistant SUBSTITUTE SHEET (RULE ?6) 98133436 ~~ ~~'fUS98101833 and much of this effort is involved in pushing tubes~ an action which is counter-intuitive to classical biopsy sampling. The preferred mode of operation of virtually all endoscopic tools is that a gripping action at the distal end of the instrument is effected by a similar action at the proximal end of the o instrument. Classical biopsy forceps jaws are closed by squeezing a manual actuation member in a syringe-like manner.
A more convenient endoscopic multiple sample biopsy device is disclosed in U.S. Patent No. 5,171,255 to Rydell. Rydell provides a flexible endoscopic instrument with a knife-sharp cutting cylinder at its distal end. A coaxial anvil is coupled to a pull wire and is actuated in the same manner as conventional biopsy forceps. When the anvil is drawn into the cylinder, tissue located between the anvil and the cylinder is cut and pushed into a storage space within the cylinder.
Several samples may be taken and held in the storage space before the device is withdrawn from the endoscope. While the device of Rydell is effective in pr~viding a multiple sample tool where each sample is obtained with a traditional two-step procedure (position and cuts, it is still limited to lateral cutting which is often problematic. Traditional biopsy forceps provide jaws which can grasp tissue frontally or laterally.
Even as such, it is difficult to position the jaws about the tissue to be sampled. lateral sampling is even more difficult.
A multiple sample biopsy forceps of a more traditional form is disclosed in co-owned U.S. Patent No. 5,592,932 to Slater et al. Slater et al. discloses an endoscopic multiple sample biopsy forceps having a jaw assembly which includes a pair of opposed toothed jaw cups each of which is coupled by a resilient arm to a base member. The base member of the jaw assembly is mounted inside a cylinder and axial movement of oa~e of the jaw assembly and cylinder relative to the other draws the arms of the jaws into~the cylinder or moves the cylinder over the arms of the jaws to bring the jaw cups together in a bitiaag action.
SU~S°~ITU'TE S~-IEET RULE 2fi) WO 98133436. ' _ ~ IaCT/US981~ 33 The arms of the jaws effectively form a storage chamber which extends proximally from the lower jaw cup and prevents accumulated biopsy samples from being squeezed laterally out from between the jaws during repeated openin<~ and closing of the jaws and the lower jaw cup enhances movement of the biopsy samples into the storage chamber. The device can hold up to four samples before it must be retrieved out of the endoscope.
However, in some biopsy procedures it is sometimes desirous to retrieve more. In addition, it has been found that samples within the chamber can stick together and make determinations of which sample came from which biopsy site somewhat difficult.
U.S. Patent No. 5,53,008 to Crowe discloses.a multiple sample bioptome which purports to take several samples and to transfer each sample by water pressure through a duct to the proximal end of the instrument, where each ~>ample can be individually retrieved. The device includes a plastic jaw set biased in an open position and coupled to the distal end of an elongate tube, up to seven feet long. The tube defines a duct.
A sleeve extends over the tube and a water :Flow passage is provided between the tube and the sleeve. An aperture is provided in the tube to permit the vaater flow passage to meet the duct at the distal end of the tube. Withdrawing the tube into the sleeve is disclosed to force the jaws closed and enable a sample to be cut from tissue and lodge in the duct. The water flow passage is disclosed to enable water to flow under pressure from the proximal end of passage to the distal end of the passage, through the aperture and into the distal end of the duct and to be aspirated to the proximal en.d of the duct, thereby transferring with it any sample contained in the duct to the proximal end where the sample can be retrieved.
While on.,paper the Crowe device is appealing, in practice the design is impractical and flawed. For example, it would be very difficult,"if not impossible, to slide the elongate tube, cip to seven feet in length, relative to a aleeve of SUBST~TU°tE SHEET (RULE 2:E) w0 98!33436 . P IIJS98I0183~
ro substantially the same lengtho It would also be difficult to maintain an unobstructed water flow passage between the tube and sleeve as the tube and sleeve curve and bend through the bodyo Furthermorea in order for the jaws to cut a tissue sample~ the tube and jaws must be drawn into the sleeve thereby undesirably pulling the jaws away from the tissue to be sampledo SL71~11~IAR~' OF' THE I~l~IENTION
It is therefore an object of the invention to provide an endoscopic biopsy forceps instrument which permits numerous tissue samples to be taken from a patient without removing the forceps from within the patiento It is another object of the invention to provide an endoscopic biopsy forceps instrument which can individually retrieve each of several tissue samples from the forceps without removing the forceps from the patience It is also an object of 'che invention to provide an endoscopic biopsy forceps instrument which irrigates the forceps and aspirates tissue samples contained therein.
It is an additional object of the invention to provide an endoscopic biopsy forceps instrument which includes a proximal actuation handle having a chamber to retain tissue samples aspirated through the instrumento It is a further object of the invention to provide an endoscopic biopsy forceps instrument which includes a proximal actuation handle for an endoscopic biopsy forceps instrument which includes a control means for controlling the aspiration and irrigation of fluid through the instruments In accord 'with these objects which will be discussed in detail below, an endoscopic biopsy forceps instrument is ~U ~'fiT~bTSI~Ei° ~CJL26~

W~ 98133436 . PCTIUS98101a33 _7_ provided and generally includes a proximal actuation handle, a distal forceps assembly, a control member coupled to the proximal actuation handle and the distal forceps assembly, and a flexible multi-lumen tubular member having an irrigation conduit, an aspiration conduit, and a control condu it which receives the control member.
According to a preferred embodiment of the invention, the proximal actuation handle includes a shaft and a spool slidably mounted on the shaft. The actuation handle is also provided with a proximal irrigation passage, a sample chamber; a sample catch member, and a pinch valve which regulates irrigation and aspiration. The proximal irrigation passage is coupled to the irrigation conduit and to an irrigation coupling tube. The sample chamber is coupled to the aspiration conduit and to an aspiration coupling tube. The sample catch member includes a screen which is inserted into the sample chamber and filters out tissue samples from the aspirated fluid. The irrigation coupling tube and the aspiration coupling tube extend through the pinch valve which operates to control the flow of fluid through the tubes. The actuation handle is coupled to the proximal ends of both the flexible tubular member and the control member.and moves the control member relative to the tubular member.
The distal assembly is coupled to the distal end of the tubular member and includes a hollow jaw cup coupled over the distal end of the aspiration conduit and a hs~llow movable jaw pivotally coupled adjacent the irrigation conduit. The jaw cup is preferably formed from a hard plastic a.nd has a blunt cutting surface, while the movable jaw is preferably a metal jaw with a sharp cutting edge. The movable jaw is further coupled to the control. member, such that actuation of the actuation handle moves the movable jaw relative to the jaw cup~ and thereby moves the jaws froii'n anvopen position to a closed position. Moving the hollow jaws to a closed position provides a substantially SU~ST1TUTE SHEET (RULE 26) ~O 98133436 ., ~'~."f/~1598/01833 ' fluidtight coupling between the irrigation and aspiration conduits.
It will be appreciated that the distal end of the instrument is brought into contact with tissue of which a.sample is required and the actuation handle is actuated to close the jaws and cut off a tissue sample. ~lith the jaws in a closed position, water is irrigated through the irrigation conduct to the jaws at the distal end of the instrument and aspirated from the jaws to the proximal end of the instrument through the aspiration conduit, such that the sample cut by the jaws .is aspirated with the water. As the water is.aspirated it passes through the chamber and the sample is filtered onto the screen.
The screen may easily be removed to retrieve the saanple. It will be further appreciated that the entire procedure of cutting a sample and retrieving the sample may be performed without removing the endoscopic biopsy forceps instrument from its location within the body.
According to one embodiment of the biopsy forceps instrument, the tubular member is avoid in shape and defines a control conduit, an irrigation conduits and an aspiration conduit. The distal forceps assembly includes a movable jaw, and a substantially rigid molded collar which is provided with a proximal socket-like coupling means for coupling the tubular member thereto, a fixed jaw cup, a distal irrigation passage, and a control passage. The collar is of similar diameter to the endoscope and is designed to be coupled to the out side of the distal end of an endoscope by a silicone rubber sock. The movable jaw is pivotally mounted on the molded collar and is movable relative to jaw cup. The tubular member is coupled in the socket. A control wire extends through the control conduit and the control passage is coupled to the two holes in the movable jaw.
SU~S°TI~'U~'E 5hlEET RULE 26) !Z!

_g_ According to a second embodiment, the biopsy forceps instrument includes a tubular member which defines can aspiration conduit having a circular cross section, an irriga toLon conduit having a kidney-shaped cross section, and two coat rol conduits.
The distal assembly includes a stationary jaw bonded to the distal end of the tubular member, and a movable jaw. The stationary jaw includes a hollow jaw cup, a clevis member and two proximal ramps. The jaw cup is located over the aspiration conduit, and the clevis and the proximal ramps extend from the jaw cup over the irrigation conduit. The movable jaw is coupled to the clevis and is guided along the proximal ramps. The two control conduits exit the distal end of the tubule r member lateral of the proximal ramps. A central portion of a control member is coupled to the movable jaw and each end of the control member extends through the control conduits to the proximal end of the instrument.
According to a third embodiment of the biops y forceps instrument, the instrument includes a tubular mercibESr which defines an aspiration conduct having a circular c rc~ss section and an irrigation conduit having a crescent-shaped cross section. The distal assembly is substantially similar to the second embodiment. The proximal ramps abut and partially cover the irrigation conduit to define two entrances into the irrigation conduit for the control members. A distal end of each control member is coupled to the movable jade and the control members extend through the entrances and into the irrigation conduit. The entrances are sufficiently small such that when the jaws are in a closed position and fluid is irrigated through the irrigation conduit to th.e distal assembly, substantially all of the fluid passes through the irrigation conduit and into the jawsP i.e. only an insubsta ntaial amount of the fluid ir.~rigated through the irrigation conduit: exits through the entrances formed by the ramps.

66~z~-4yy~
9a In one broad aspect, the invention provides a tubular member for use with a biopsy forceps instrument for retrieving tissue samples from a patient for use with an endoscope, comprisinga a) a multi-lumen tubular extrusion provided with an aspiration conduit and at least one irrigation conduit; and b) at least one support wire co-extruded with said mufti-lumen extrusion and having proximal and distal ends.

WO 98!33436 , P~LTIUS98! 33 _!g_ Additional objects and advantages of the invention will become apparent to those skilled in the art upon reference to the detailed description taken in conjunction with t3~e provided figures.
BRIEF DES.~RIPTION OF T~iE DRAtniINGS
Figure 1 is a broken perspective view of a first. embodiment of an endoscopic biopsy forceps instrument according to the invention;
Figure 2 is a broken perspective view of the proximal end of the first embodiment of the invention;
Figure 3 is a broken perspective view of the sample chamber of the first embodiment of the inventioxl;
Figure 9 is a perspective view of the front side of the sample catch member of the first embodiment of the invention;
Figure 5 is a perspective view of the back side of the sample catch member of the first embodiment of the invention;
Figure 6 is an enlarged broken perspective view of the tubular member of the first embodiment of the invention;
Figure 7 is an enlarged broken perspective view of the distal assembly of the first embodiment of the invention with the jaws in an open position;
Figure 8 is an enlarged broken perspective view of the distal assembly of the first embodiment of the invention with the jaws in~a.closed position;
Figure 9.is a bottom end view of Figure 8;
SUBSTITUTE StiEfT (RULE 2E) WO 98133436 ~ PCTIUS9810~

Figure 10 is a cross section acrflss line 10-10 of Figure 7;
Figure 11 is cross section across line 11-11 of Figure ~:
Figure 12 is a broken perspective view of the distal assembly of the first embodiment illustrating an alternate control member configuration;
Figure 13 is a broken perspective view of the distal assembly of the first embodiment illustrating another alternate control member configuration: w Figure 14 is a front elevation view of a sample catch assembly according to a second embodiment of the invention;
Figure 15 is a top view of the sample catch assembly according to the second embodiment of the iiwention;
Figure 16 is cross section view through line 16-16 in Figure 14;
Figure 17 is a side elevation view of the sample catch assembly according to the second embodiment of the invention;
Figure 18 is a front elevation view of the sample tray of the sample catch assembly according to the second embodiment of the invention;
Figure 19 is a broken perspective view of a third embodiment of an endoscopic biopsy forceps instrument of the invention;
Figure 20 is an enlarged broken transparent perspective view of the tubular member of the third embodiment of the invention; ~ >.
SU~aTITUTE SHEET (f~ULE 26) 98133436 PC3'11J898101833 _12_ Figure 21 is an enlarged cross section across line 21-21 of Figure 20~
Figure 22 is an enlarged broken perspective view of the distal assembly of the third embodiment of the inverztion with the jaws in an open positions Figure 23 is a cross section across line 23-23 of Figure 22;
Figure 24 is an enlarged broken perspective view of the distal end of the third embodiment of the invention with the biopsy jaws in a closed position;
Figure 25 is a cross sectson across line 25-25 of Figure 24;
Figure 26 is an enlarged broken transparent perspective view of the tubular member of the fourth emboda~ment of the invention;
Figure 27 is an enlarged cross-section across line 27-27 of Figure 26;
Figure 28 is a enlarged broken perspective view of the distal end of a fourth embodiment of the invention with the jaws in an open position;
Figure 29 is a cross-section of a tubular mertsber according to a fifth embodiment of the invention; and Figure 30 is a cross-section of a tubular mennber according to a sixth embodiment of the inventions ~US°~~'fUT~ SHEET ~FIIJL2~) 'w~
WO 98133436 PC'f/US98I0 DETAILED DESCRIPTION OF THE PREFERRE1:~ EMBODIMENTS
Turning now to Figure 1, a multiple sample biopsy forceps instrument 10 is shown. The biopsy forceps instrument generally includes a proximal actuation handle 12, a flexible mufti-lumen tubular member 19, a pull wire 20, and a distal assembly 22.
Several coupling tubes are preferably provided to couple the proximal actuation handle 12 to the tubular member 19 and to irrigation and aspiration means. In particular, a control coupling tube 23, first and second irrigation coupling tubes 24, 25 and first and second aspiration coupling tubes 26, 27 are provided.
The proximal actuation handle 12 includes a shaft 30 having a transverse slot 32 and a spool 34 slidably moL~nted on the shaft and having a transverse bar (not shown) extending through the slot 32, as is common in the aria. The actuation handle 12 is provided with a pinch valve 45 which regulates irrigation and aspiration and a sample catch assembly 41 which includes a sample chamber 42 and a sample catch member 44. Turning to Figures 2 and 3, the sample chamber 42 includes irrigation connectors 96, 47 which cauple the first i3_rigation coupling tube 24 to the second irrigation coupling tube 25. The sample chamber 42 also includes first and second aspiration connectors 48, 49 which couple the first aspiration coupling tube 26 to the second aspiration coupling tube 27. As shown i.n Figure 3, the diameter of the chamber 42 is significantly larger than the diameter of the first (and second) aspiration coupling tubes 26 (,27). As also shown in Figure 3, the chamber 42 includes a sample catch connector 43 for removably coupling the chamber to a distal portion of the shaft 30. The sample catch connector 43 is preferably T-shaped for mating with a slot (not shown) on the shaft 30, but may be otherwise shaped for connection to the shaft. Referring to Figures 3 through 5, the sample catch member 44 includes a handle portion 52, an engagement portion 59 which removably engages the sample catch n;~ember 4 ~ to the sar,~ple SU~STtTUT~ SHEET ~RUI.E ~6) _14_ chamber 42, and a screen 56. The screen 56 extends through the sample chamber 42 between the first and second aspi ration connectors 48, 49. The screen 56 includes a front side 58 and a back side 60 and is provided with a plurality of perforations 62 which are preferably frustoconical in shape and expand from the front side 58 to the back side 60. As further shown in Figures 3 through 5, the engagement portion 54 and the opening of the sample chamber 42 preferably have irregular shaped cross-sections which enable the engagement of the engagement portion 59 into the sample chamber 92 in one orientation only. As a result, the frustoconicai perforations 62 of the s creep S6 can be easily aligned in the proper front to back orientation.
As shown in Figure 2, the first irrigati on coupling tube 24 and the first aspiration coupling tube 26 extend through the pinch valve 45 which operates to control the flow of fluid through the tubes 24, 26. The pinch valve is biased to clamp closed the first irrigation coupling tube 24 and the first aspiration coupling tube 26, i.e, to collaps a the tubes on top of each other. Pressing downward on the pinch valve 45 with a practitioner's finger counters the bias of the pinch valve to permit fluid flow through the first irrig anon coupling tube 24 and the first aspiration coupling tube 26.
Turning to Figures 6 and 7, and in accord with the first embodiment of the invention, the tubular member 14 is preferably an ovoid mufti-lumen extrusion. The tubular member includes a proximal end 66, a distal end 68, a control conduit 70, an irrigation conduit 72, and an aspiration conduit 79, each of which extends through the tubular member to the distal assembly 22. At the proximal end 66 of the tubular member, the control conduit 70 is coupled to the control coupling tube 23, the irrigation conduit 72 is coupled to the second irrigation coupling tube~25 and,the aspiration conduit 79 is coupled to the second aspira~~ion coupling tube 27.

66822-499 ~/

Ref erring to Figures 7 through.9, the distal assembly 22 includes a substantially rigid molded collar 80 and a hollow movable jaw 90. The collar 80 is preferably made from a unitary piece of polycarbonate, a glass-filled polycarbonate, a hard grade styrene, or other plastic, while the movable jaw 90 is preferably made from cast metal. The collar includes a central opening 81, a circumferential channel 83, a distal 1y extending control passage 82, a distally extending hollow jaw mount 84, a distally extending hollow stationary jaw 88, and a proximal socket 86.~ The central opening 81 of the collar. 80 is of similar diameter to the outer diameter of the endoscope and is designed to couple the collar to the outside of the distal end of an endoscope. The circumferential channel 81 receives a portion of a silicone rubber sock tnot shown?, which is used to secure the collar 80 to the endoscope.
The stationary jaw 88 preferably includes a blunt edge or lip 92. The movable jaw 90 is pivotally mounted at-a pivot 94 on the jaw mount 84 and is pivotable relative t:o stationary jaw 88. The movable jaw 90 is preferably provided with a sharp cutting edge 98, a stop 100 for limiting the extent to which the movable jaw pivots away from the stationary jaw 88, and two jaw holes 102, 104, for receiving a pull wire 20, as described below.
Referring to Figures 9 through 11, the proximal socket 86 is aligned with the control passage 82, the jaw mount 84 and the stationary jaw 88, and is designed to receive the distal end 68 of the flexible tubular member 14. The distal end 68 of the tubular member is secured in the proximal socket 86., preferably using an adhesion bonding agent, such that the control passage 82 is coupled to the control conduit 70, the jaw mount 89 is coupled substantially fluidtight 'to the irrigation conduit °72, and the stationary jaw 88 is coupled substantially fluidtight to the aspiratio~ri conduit - 74.

-~ I6--Turning back to Figures 1, 6, and 11, a cent ral portion of the pull wire 20 extends through the jaw holes 1~ 2, 109 and the ends of the pull wire 20 extend through the corat r of passage 82, the control conduit 7~~ and the control coupling tube 23 to the y spool 39. Referring to Figure 12, alternatively the pull wire 20a forms a secure loop 106a through the jaw hole's 102x, 104a by doubling back on itself and forming a twiat 108a0 Referring to Figure 13, in yet another alternative, two pull wfi res 20b, 21b may be used, the distal end of eaoh pull wire be Wing coupled to a jaw hole 102b, 104b by a Z-bend 110b; 112:b and extending through the control passage 82b.
Referring to Figures l, 7, and 8, it will be appreciated that movement of the spool 39 relative to the shaft 30 results in movement of the pull wire 20 relative to tt~e tubular member 19 and consequently moves the movable jar~r 90 relative to the stationary jaw 88 such that the jaws open (Figure 7) and cl~se (Figure 8). Referring to Figures 7 through 31, when the stationary and movable jaws 88, 90 are in a c.los ed position a substantially fluidtight passage is formed therebetween.
Because the stationary jaw 88 is coupled to the aspiration conduit 74 and the movable jaw 90 is coupled over the irrigation conduit 72, a substantially fluidtight coupling of the irrigation and aspiration conduits is achieved.
In use, it will be appreciated that. the distal end of the endoscope to which the collar 80 is coupled is maneuvered adjacent the desired tissue far sampling and the distal assembly is brought into contact with tissue 110 (Figure s 10 and 11).
The actuation handle 12 is actuated to crlose the jaws 88, 90 and cut off a tissue sample 112. When the jaws 88, 90 are in a closed position, the irrigation means and the aspiration means are activated and the first proximal irrigation coupling tube and the first.proximal aspiration couplang tube 29, 26 are released from~the clamping action of the pinch valve 93 by depressing the pinch valve. Irrigating fluic. is thereby _17_ permitted-to flow through the first and second proximal irrigation coupling tubes 24, 26, through the irrig ~ti.on conduit 72 and the hollow jaw mount 84, and 'to the jaws 88, 90 at the distal end of, the instrument. The fluid flows thro ugh the jaws and is aspirated back to the proximal end of the ia~strument such that the sample held within the jaws is aspirated with the water. Turning back to Figures 2 through 6, as the water is aspirated through the aspiration conduit 74 and int o the sample chamber 42, the sample is filtered onto the screen 58. The frustoconical shape of the perforations 62 p~ermii:s increased fluid flow through the perforate screen while prEwenting .the tissue sample from passing through the screen. :Ir ~ igation and aspiration means are interrupted by releasing the finch valve 95 such that the pinch valve clamps down on the first proximal irrigation and aspiration coupling tubes 24, 26 an d causes the tubes to collapse on top of each other. Th~~ scree n 58 may easily be removed to retrieve the sample by grippirag the handle portion 52 of the sample catch member 99 and pulling the sample catch member from the sample chamber 92. The camp 1e is recovered from the screen, and the sample catch meanber is reinserted into the sample chamber to continue the procedure.
It will be further appreciated that the entire pro cedure of cutting a sample and retrieving the sample may be performed without removing the endoscopic multiple sample biopsy forceps instrument from its location within the bodly. Un~ invited subsequent samples may be obtained in an identica 3 manner.
A second embodiment of the proximal acauatioaz handle is also provided, substantially similar to the' first embodiment.
Referring to Figures 14 to 18, the second embodiment has an alternate sample catch assembly 900 able tc~ receive and keep separate samples without necessitating the ramous 1 of a sample catch betweea~ each sample retrieval. The ;sample catch assembly 900 generally includes a sample tray holder 902 h suing front and rear walls 908; 910, a sample tray 904 situated in the tray holder between the front and rear walls, a:r~d a threaded _1g_ connector 9fl6 extending through the front wal.1 9fl8 of the tray holder 902 and the tray 904 and removably thz:eaded into the rear wall. The tray 904 is rotatable about the threaded connector 906 and relative to the tray holder 902. The=_ threaded connector preferably includes an enlarged head 912 for easier manipulation by a practitioner's fingers.
The front wall 908 of the tray holder 902 includes a first bore 916 (see Fig. 16} through which extends the threaded connector 906, an inside surface 917, and a first aspiration connector 918 which extends through the front wa7_1 908 to the inside surface 917. The rear wall 910 is provided with a second bore 920, preferably threaded, into which the threaded connector 906 is secured, and a sample catch connector 926 which removably couples the sample catch assembly 900 to a clista:l portion of the shaft 30. The rear wall is also provided with an inside surface 921, a second aspiration connector 922, and a proximal aspiration conduit 924 extending from the inside surface 921 to the second aspiration connector 922. The tray holder 902 is also preferable provided with irrigation connectors 914, 915 which couple the first irrigation coupling tube 24 to the second irrigation coupling tube 25.
The tray 904, preferably polygonally shaped, includes an axial bore 927 and a plurality of chambers or cups 92$a-h (indexed 1 through 8, respectively, in Fig. 18). Referring to Figures 16 and 18, each cup 928x-h has a filter or screen 930a-h and tapers to an outlet 932a-h (932x, 932e shown in Fig. 1~}
proximal of the screen. The screen prefe~a.bly lnas frustoconical perforations. The tray 904 is rotatable w~.thin tl~e tray holder 902 such that each of the cups 928a-h is positionabl.e between the first aspiration connector 918 and the proximal aspiration conduit 924:for receiving a tissue sample. The cups 928a-h are maintained in position by providing indentations 934a-h in the tray 904 which receives a protruberance 93.'~ on the inside surface 921 of the rear wall 910 ( see Fig . 15 a.nci 17 } ; f ..e . ~ a SU~STiTUTE SHEET (RULE "e'.~) ~ O 9813343b ~~ PCTIUS98J01833 cud (for example, 928a) is held is position until sufficient force is provided to the tray 909 to rotate the tray and thereby position the next cup (for example, 928b) fo:~ receiving a tissue sample. Each of the cups may thereby be positioned to receive a tissue sample without necessitating the removal of a screen between retrieving individual tissue samples. Alternatively, or in conjunction with the indentations 934a-h and the protruberance 935, a ratchet mechanism (not shown) can be provided to prevent rotation of a tray opposite to a predetermined direction. Preferably a stop 936 is also provided on the tray 904 to prevent the tray from being rotated through more than one cycle without first retrieving the samples received in the cups;wi.e., to prevent contamination of an earlier retrieved sample by a later retrieved sample. The tray is also preferably provided with indicia 938 to indicate to the practitioner which cup is currently positioned to receive a sample.
After an individual sample has been received into a ffirst cup, according to a similar method as described above with respect to the first embodiment, the aspiration and irrigation are interrupted and the tray 904 is rotated such that the next cup is positioned between the first aspiration connector 918 and the proximal aspiration conduit 929. The process is repeated after each sample is received into a cup. once the practitioner has obtained all of the desired samples, or once each cup of the tray contains a sample, the threaded connector 906 is uncoupled and the tray is removed and the samples may be reranoved from the cups of the tray. Index numbers adjacent the cups indicate the order in which the samples were retrieved.
Turning to Figure 19 and 20, a third embodiment of a multiple sample biopsy forceps instrument 210 is shown. The instrument includes a proximal actuation handle 212, a flexible mufti-lumen t-ubul.ar member 214, a pull wire 220, and a distal assembly 222. Several coupling tubes are preferably provided to SU~ST1TUTE SHEET (RULE 26) t:,.,,' ' couple the proximal actuation handle 212 to the tubular member 214 and to irrigation and aspiration means. In particular, a Y-shaped control coupling tube 223, first and second irrigation coupling tubes 224, 225~ and first and second aspiration coupling tubes 226~ 227 are provided.
The praximal actuation handle 212 is substantially similar to the first embodiment (with like parts having numbers incremented by 2009 Referring to Figure 20, 21 and 22, the tubular member 214 is preferably a mufti-lumen mufti-layer extrusion, and preferably includes a first metal braid 276 beneath the outermost layer to add desired stiffness to the tubular member. If desiredo a second metal braid 277 may be additionally provided around the aspiration conduit 274 to stiffen and support the aspiration conduit 274. The tubular member 214 has a proximal end 266, a distal end 268, two control conduits 270, 271, an irrigation conduit 272, and an aspiration conduit 274, each of the conduits 270, 271, 272, 274 extending through the tubular member to the distal assembly 222. The aspiration conduit 274 has a substantially circular cross section. The irrigation conduit 272 has a generally kidney-shaped cross section and is separated from the aspiration conduit 274 by a membrane 275. The control conduits 270v 271 are preferably situated one on either end of the membrane 275.
Referring to Figures 22 through 25, the distal assembly 222 according to the third embodiment of the invention includes a stationary jaw 281 coupled, preferably by adhesion bonding, to the distal end 268 of the tubular member. The stationary jaw 281, preferably made of plastic, includes a jaw cup 288, an integral central clevis 293 and integral proximal ramps 2958 296. The jaw cup 288 is located over the aspiration conduit 274 and preferably has a blunt cutting surface or lip 292. The central clevis 293 and proximal ramps 295, 296 extend from the stationary jaw 281 and abut and partially cover the irrigation conduit. A movable jaw 290, preferably made of metal, is StJ~S?'ffU'TE S~iEE'~ ~RUI.E 2E) WO 98!33436 , ~ PCT/U598/01$33 provided with a sharp cutting edge 298, defines two jaw holes 3Q2, 304 for receiving a pull wire 220, and is provided with 'two bosses 312, 314 for mounting the jaw. The bosses 312, 314 loosely engage the central clevis 293 and a p~.vot: pin 294 extends through the bosses and the central clevis. The ramps 295, 296 of the stationary jaw 281 guide the movable jaw 290 when opening and closing and assist to form a substantially fluidtight passage between the movable jaw 290 snd the stationary jaw cup 288 when the jaws are in a closed position.
A central portion of the pull wire 220 which is perpendicular to the longitudinal axis of the instrument extends through the jaw holes 372, 304 and the ends of the pull wire extend into the control conduits 270, 271. Turning back to Figure 20, the Y-shaped coupling tube 223 facilitates alignment of th.e ends of the pull wire 220 for coupling the pull wire to the proximal actuation handle. The pull wire 22U may be coated, e.g., in a plastic, to inhibit the pull wire from cutting into the tubular member.
Referring to Figures 23 and 25, the distal end 268 of the tubular member is inserted through the lumen of an endoscope to a biopsy site. The jaws 288, 290 are moved into a closed position cutting off a tissue sample and further providing a substantially fluidtight coupling between the irrigation and aspiration conduits 2?2, 274. While it appears from the illustrations of Figures 23 and 25 that the irrigation conduit 272 is obstructed at the distal end by clevis 293, it will be appreciated that the irrigation conduit 272 is substantially wider than the clevis and that fluid may flow around the clevis to the aspiration conduit 274.
Turning now to Figures 26 through 28, a fourth embodiment of a multiple sample biopsy forceps, substantially similar to the third embodiment (with like parts having numbers incremented by another 20'0) 'i's shown.. The tubular member 914 has a proximal end 466, a distal end 468, an irrigation conduit 472, and an SU~ST1TUTE SHEET (RULE ~6) ~ ~ ~w.J
WO 98133436 PC~'IIJS98101833 aspiration conduit 474. The aspiration conduit 474 has a substantially circular cross section, while the irrigation conduit 472 has a generally crescent-shaped cross sectione A
control coupling tube 423 is coupled to the second irrigation coupling tube 425. Two pull wires 420, 421 extend through the control coupling tube 423, pass through a substantially fluidtight valve (not shown) coupling the control coupling tube 423 and the second irrigation coupling tube 425, enter into the second irrigation coupling tube 425, and extend thr~ugh the irrigation conduit 472 to the distal end 468 of the tubular member. An aspiration coupling tube 427 is coupled to the aspiration conduit 474.
Referring to Figure,28, the distal assembly 42 2 of the fourth embodiment of the invention includes a stationary jaw 481 bonded to the distal end 968 of ~.he tubular member~ and a movable jaw 490 coupled thereto. The stationary jaw 481 includes a jaw cup 988, an integral central clevis 493, and ramps 495, 496. The~jaw cup abuts the distal end of the tubular member and is positioned over the aspiration conduit 474 and preferably has a blunt cutting surface or lip 992. The central clevis 493 and ramps 495, 496 extend from the scat ionary jaw 481 and abut and partially cover -the irrigation conduit 474. A
movable jaw 990, preferably made of metal, is prow ided with a sharp cutting edge 498, defines two jaw holes 902, 404 for receiving a pull wire 9209 and is provided with two bosses 51.2~
519 for mounting the jaw. The bosses 512, 514 loo sely engage the central clevis 493 and a pivot pin 494 extends through the bosses and the central clevis. By partially covering the irrigation conduit, the ramps form entrances 499, 500 for the pull wires. The movable jaw 990 rides on the proximal ramps 995, 496 when moving from an open to a closed position. The pull wires 420, 421 are coupled to the jaw holes 502, 504 by a Z-bend 50&, 507 and extend through the entrances 999, 500 unto the irrigation conduit 972~ through a portion of the second irrigation coupling tube 425a and further into a control ~UBBi'i~'LffE SHEET (BULB 26~

~ ' " .."~~
WO 98133436 PC'TIUS98I01833 coupling tube 423 coupled thereto. The entrances 499, 500 are sufficiently small that only an insubstantial amount of fluid exits from the irrigation conduit when the jaws are in a closed position and irrigant is forced through the irrigation conduit 474 to the distal assembly.
Turning to Figure 29, a fifth embodiment of the invention, substantially similar to the fourth embodiment (vaith like parts having numbers incremented by 200) is shown. The tubular member 614 is preferably a mufti-lumen extrusion co-extruded with support wires 676, 677, 578. The tubular member 614 has two irrigation conduits 6?2, 673, and an aspirat=ion conduit 674.
The aspiration conduit 674 has a substantially circular cross section, and the irrigation conduits 672, 6'73 have a generally ovoid cross section. The extrusion is preferably made of a polymer (e. g., polyurethane, a polyether block amide, polyethylene, or PVC) or another bondable material. ~ pull wire 620, 621 extends through each irrigation conduit. 672, 673. By way of example, the preferred diameter for the tubular member 614 is approximately 2.8 - 3.3 mm, the preferred diameter for the aspiration conduit 679 is approximately 1.5 mm, and the preferred diameter for each of the support wires 676, 677, 678 is approximately 0.4 mm. The support wires are preferably made of stainless steel and are also preferably round, but alternatively may be flat. The tubular member of the fifth embodiment is incorporated into the invention in a manner substantially similar to the tubular member of the faurth embodiment and several advantages are real:i~ed with this embodiment. First, a three support wire co-extrusion prcwides necessary rigidity to the wall of the aspiration conduit.
Second, the three wire co-extrusion is easy to manufacturer.
Turning to Figure 30, it will be further appreciated that the three support wires may be replaced with a single larger high tensile"support wire 676a or rnultiband cable through'the tubular member 619a. The support wire is preferably located SUEST~TUTE SHEET (RULE 2b~

O 98/33436 PCTI<1S98101833 _24-substantially between the two irrigation conduits and the aspiration conduit. The single support wire 67~a provides necessary support to the aspiration conduit 679a and is also easy to manufacture. Moreover, the entire support w ire or dust its distal end may be made from a shape memory mate rial, e.g., Nitinol, which will bend in a predetermined manner when heated to a predetermined temperature. As a result, by he sting the support wire to a predetermined temperature, e.g.8 ~y applying a current thereto, the shape memory distal end of the support wire can be made to bend in a predetermined manner and consequently the tubular member can be made to bend in a predate mined , manner. Tissue samples can thereby be retrieved which are not linearly aligned with the endoscope through which tl-~e distal end of the biopsy forceps instrument extends.
There have been described and illustrated here in several embodiments of a multiple sample endoscopic biopsy ~.nstrument.
While particular embodiments of the invention have been described, it is not intended that the invention be limited thereto, as it is intended that the invention be a s broad in scope as the art will allow and that the specificat ion be read likewise. Therefore~ while a particular manner of coupling the proximal actuation handle to the tubular member ha s been disclosed for the several embodaments~ it will be appreciated that other manners of coupling the proximal and distal assemblies may be used as well. In addition, whil a a pinch valve is described for regulating aspiration and irrigation through the tubular member, it will be appreciated that other valve means may likewise be used to the same effect. Also, it will be appreciated that separate valve means may be provided to individually control aspiration and irrigation. It will also be appreciated that while the valve means has been shown coupled to the proximal actuation~handle, the valve means may be separable and/or independent from the proximal actuation handle.
Furthermore,~~while the chamber has been described as being removably coupled to the shaft, it will be appreciated that the Si9~STITUTE S~iEET (E~IiLE 26) ~ .. .. ~i~% "~
W~ 98!33436 PCTIiJS98/0~833 chamber may be integral with the shaft or, alternatively, not coupled to the actuation handle. Moreover, the sl-dapes of the chamber and the catch member may be different from that described. In addition, it is not necessary to provide first and second irrigation connectors as a single uninterrupted coupling tube may extend from the irrigation cond~,it of the tubular member through the valve means. Furt.hermor~e, while a spool and shaft type actuation means has been disclosed which moves the pull wires) relative to the tubular me~nber~ it will be appreciated that the actuation means may x>e of another type well known in the art. For example, a laparoscopic type handle (scissor-type) may also be used. It will therefore be appreciated by those skilled in the art that yet other modifications could be made to the provided :invention without deviating from its spirit and scope as so claimed.
SU~STiTUT~E Si-iEET (RULE 2~)

Claims

CLAIMS:

1. ~A tubular member for use with a biopsy forceps instrument for retrieving tissue samples from a patient for use with an endoscope, comprising:
a) a multi-lumen tubular extrusion provided with an aspiration conduit and at least one irrigation conduit;
and b) at least one support wire co-extruded with said multi-lumen extrusion and having proximal and distal ends.

2. ~A tubular member according to claim 1, wherein:
said at least one support wire has a distal end formed from a shape memory metal.

3. ~A tubular member according to claim 1, wherein:
said multi-lumen extrusion is made of a polymer.

4. ~A tubular member according to claim 1, wherein:
said at least one support wire is made of one of a rounded wire, a flat wire, and a multi-strand cable.

5. ~A tubular member according to claim 4, wherein:
said at least one support wire is made of stainless steel.

6. ~A tubular member according to claim 1, wherein:
said multi-lumen extrusion has exactly two irrigation conduits and exactly one support wire is co-extruded with said multi-lumen extrusion, s.nd said support wire is located substantially between each of said two irrigation conduits and said aspiration conduit.