CA2432284A1 - Antibiotic calcium phosphate coating - Google Patents

Antibiotic calcium phosphate coating Download PDF

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Publication number
CA2432284A1
CA2432284A1 CA002432284A CA2432284A CA2432284A1 CA 2432284 A1 CA2432284 A1 CA 2432284A1 CA 002432284 A CA002432284 A CA 002432284A CA 2432284 A CA2432284 A CA 2432284A CA 2432284 A1 CA2432284 A1 CA 2432284A1
Authority
CA
Canada
Prior art keywords
calcium phosphate
implant
therapeutic agent
phosphate coating
antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002432284A
Other languages
French (fr)
Other versions
CA2432284C (en
Inventor
Christopher Scott
Joseph Zitelli
Paul Higham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Howmedica Osteonics Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2432284A1 publication Critical patent/CA2432284A1/en
Application granted granted Critical
Publication of CA2432284C publication Critical patent/CA2432284C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Abstract

A process for applying a coating having a therapeutic agent such as an antibiotic to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.
CA002432284A 2001-10-24 2002-10-22 Antibiotic calcium phosphate coating Expired - Fee Related CA2432284C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/001,525 US6596338B2 (en) 2001-10-24 2001-10-24 Antibiotic calcium phosphate coating
US10/001,525 2001-10-24
PCT/US2002/033675 WO2003035123A1 (en) 2001-10-24 2002-10-22 Antibiotic calcium phosphate coating

Publications (2)

Publication Number Publication Date
CA2432284A1 true CA2432284A1 (en) 2003-05-01
CA2432284C CA2432284C (en) 2008-03-18

Family

ID=21696484

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002432284A Expired - Fee Related CA2432284C (en) 2001-10-24 2002-10-22 Antibiotic calcium phosphate coating

Country Status (6)

Country Link
US (2) US6596338B2 (en)
EP (1) EP1438080A4 (en)
JP (1) JP2005506879A (en)
AU (1) AU2002347989B2 (en)
CA (1) CA2432284C (en)
WO (1) WO2003035123A1 (en)

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WO2009132411A1 (en) * 2008-04-28 2009-11-05 The University Of British Columbia Polymer-free drug delivery system for implantable medical devices

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Publication number Priority date Publication date Assignee Title
WO2009132411A1 (en) * 2008-04-28 2009-11-05 The University Of British Columbia Polymer-free drug delivery system for implantable medical devices

Also Published As

Publication number Publication date
US20040001911A1 (en) 2004-01-01
WO2003035123A1 (en) 2003-05-01
CA2432284C (en) 2008-03-18
US6821528B2 (en) 2004-11-23
AU2002347989B2 (en) 2007-07-19
US20030077381A1 (en) 2003-04-24
US6596338B2 (en) 2003-07-22
EP1438080A1 (en) 2004-07-21
EP1438080A4 (en) 2010-03-17
JP2005506879A (en) 2005-03-10

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Effective date: 20201022