CA2437057A1 - Biological fluid filtration system - Google Patents
Biological fluid filtration system Download PDFInfo
- Publication number
- CA2437057A1 CA2437057A1 CA002437057A CA2437057A CA2437057A1 CA 2437057 A1 CA2437057 A1 CA 2437057A1 CA 002437057 A CA002437057 A CA 002437057A CA 2437057 A CA2437057 A CA 2437057A CA 2437057 A1 CA2437057 A1 CA 2437057A1
- Authority
- CA
- Canada
- Prior art keywords
- tubing
- channel
- curvilinear
- support
- support member
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/1414—Hanging-up devices
- A61M5/1418—Clips, separators or the like for supporting tubes or leads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
- A61M1/0218—Multiple bag systems for separating or storing blood components with filters
- A61M1/0222—Multiple bag systems for separating or storing blood components with filters and filter bypass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0439—White blood cells; Leucocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/08—Supports for equipment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/08—Tubes; Storage means specially adapted therefor
Abstract
An improved tubing device (30), preferably for use in the medical industruy is provided. The tubing device provides a seamless transport path (32) by using the tubing itself as the transport means without any other internally wetted parts, or connections, to provide a substantial reduction in the number of fluid contact components, and eliminate the need for cutting tubes into segments to be later bonded via tubing connectors. This can reduce the risk of contamination of the transported materials and can also reduce the use of chemicals such as adhesives and bonding agents.
Claims (58)
1. A tubing device for transporting fluids comprising:
a support member, said support member comprising:
a curvilinear channel formed therein for receiving a tube; and an adhesive disposed in said channel for securing a tubing into the channel.
a support member, said support member comprising:
a curvilinear channel formed therein for receiving a tube; and an adhesive disposed in said channel for securing a tubing into the channel.
2. The tubing device according to claim 1, further comprising a flexible tube, said flexible tube being disposed in said channel of said support member.
3. The tubing device according to claim 2, wherein said support member comprises an aperture for hanging said tubing device.
4. The tubing device according to claim 2, wherein said curvilinear channel comprises at least one of: a "U" bend, a right angle bend and a straight section.
5. The tubing device according to claim 2, wherein the interior of said tubing is free of adhesives.
6. The tubing device according to claim 2, wherein said channel has a substantially semi-circular cross section.
7. The tubing device according to claim 2, wherein said channel has a cross section which comprises an arc which is greater than a semi-circle.
8. The tubing device according to claim 7, wherein said tubing is held in said channel of said support device by the greater than semi-circular cross section of said channel.
9. The tubing device according to claim 8, wherein said channel comprises an opening to allow a tube to be inserted into said channel, and said opening is less than the outer diameter of said tubing.
10. The tubing device according to claim 2, wherein the outer diameter of said tubing is substantially equal to the inner diameter of said channel.
11. The tubing device according to claim 2, wherein said channel comprises a "U"-bend, and the legs of said U-bend are oriented substantially perpendicular to the direction the tubing device is designed to hang, to prevent the gravitational forces acting on the device deforming the "U"-shape into a "V"-shape.
12. The tubing device according to claim 1, wherein said curvilinear channel is a first curvilinear channel, and said support member comprises a second curvilinear channel, said second curvilinear channel being disposed adjacent to said first curvilinear channel and within said support member.
13. A tubing device for transporting fluids comprising:
a support member, said member comprising:
a curvilinear channel formed therein for receiving a tube, wherein said curvilinear channel is a first curvilinear channel; and said support member comprises a second curvilinear channel, said second curvilinear being disposed adjacent said first curvilinear channel and within said support member, wherein second curvilinear channel has a diameter less than the cross section of said first curvilinear channel;
and an adhesive disposed in said channel for securing a tubing into the channel.
a support member, said member comprising:
a curvilinear channel formed therein for receiving a tube, wherein said curvilinear channel is a first curvilinear channel; and said support member comprises a second curvilinear channel, said second curvilinear being disposed adjacent said first curvilinear channel and within said support member, wherein second curvilinear channel has a diameter less than the cross section of said first curvilinear channel;
and an adhesive disposed in said channel for securing a tubing into the channel.
14. The tubing device according to claim 13, comprising first and second pieces of flexible tubing, said first piece of flexible tubing being disposed in said first curvilinear channel, and said second piece of curvilinear tubing being disposed in said second curvilinear channel.
15. A tubing device for use in the medical industry, said tubing device comprising:
a tube support comprising a curvilinear channel disposed therein for receiving a piece of tubing; and means for holding a piece of tubing in said channel.
a tube support comprising a curvilinear channel disposed therein for receiving a piece of tubing; and means for holding a piece of tubing in said channel.
16. The tubing device according to claim 15, wherein said means for holding comprises adhesive.
17. The tubing device according to claim 15, wherein said channel has a semi-circular cross-section.
18. The tubing device according to claim 15, wherein said channel has a cross-section with a greater than semi-circular cross-section.
19. The tubing device according to claim 18, wherein said means for holding comprises said greater than semi-circular cross-section.
20. A tubing device for use in the medical industry, said tubing device comprising:
a tube support comprising a curvilinear channel disposed therein for receiving a piece of tubing, wherein said support device further comprises a first portion and a second portion, said first and second portions being connected by a hinge; and means for holding a piece of tubing in said channel.
a tube support comprising a curvilinear channel disposed therein for receiving a piece of tubing, wherein said support device further comprises a first portion and a second portion, said first and second portions being connected by a hinge; and means for holding a piece of tubing in said channel.
21. The tubing device according to claim 20, wherein each of said first portion and said second portion of said tubing device comprises a channel.
22. The tubing device according to claim 21, wherein said channel in said first portion and said channel in said second portion are configured to align with each other to hold a piece of tubing between them.
23. The tubing device according to claim 22, wherein said channel in said first portion and said channel in said second portion are configured to form a cylindrical channel when aligned.
24. The tubing device according to claim 23, wherein said channel in said first portion and said channel in said second portion each has a semi-circular cross section.
25. The tubing device according to claim 23, wherein said channel in said first portion has a greater than semi-circular cross section, and said channel in said second section has a less than semi-circular cross-section.
26. The tubing device according to claim 15, wherein said curvilinear channel is a first curvilinear channel, and said support member comprises a second curvilinear channel, said second curvilinear channel being disposed adjacent to said first curvilinear channel and within said support member.
27. The tubing device according to claim 26, wherein said second curvilinear channel has a diameter less than the cross section of said first curvilinear channel.
28. The tubing device according to claim 27, comprising first and second pieces of flexible tubing, said first piece of flexible tubing being disposed in said first curvilinear channel, and said second piece of curvilinear tubing being disposed in said second curvilinear channel.
29. The tubing device according to claim 27, wherein the outer periphery of said first channel overlaps the outer periphery of said second channel.
30. The tubing device according to claim 27, wherein said support device comprises a barrier between said first and second channels, said barrier comprising a slot to allow communication between said first and second channels.
31. The tubing device according to claim 15, wherein said support member comprises an additional curvilinear channel, said additional curvilinear channel being disposed on an opposing face of said support member from said first curvilinear channel.
32. The tubing device according to claim 15, wherein said support member comprises an aperture for hanging said tubing device.
33. The tubing device according to claim 15, wherein said support device comprises opposing faces and a circumferential edge, and said curvilinear channel comprises a trough disposed along at least a portion of said circumferential edge.
34. The tubing device according to claim 15, wherein said support device comprises apertures to reduce the weight of said support device.
35. A tubing device for transporting a biological fluid, said tubing device comprising:
a tube support comprising a curvilinear channel disposed therein for receiving a piece of tubing; and structure to hold a piece of flexible tubing in said channel.
a tube support comprising a curvilinear channel disposed therein for receiving a piece of tubing; and structure to hold a piece of flexible tubing in said channel.
36. The tubing device according to claim 25, further comprising a piece of flexible tubing disposed in said channel.
37. A method for transporting a fluid for a medical application, said method comprising:
providing a piece of flexible tubing, the tubing comprising a single piece and having no adhesives on the interior surfaces;
providing a support device for the flexible tubing, the support device being configured to prevent flow constricting areas from forming in the flexible tubing;
and transporting a fluid through the flexible tubing.
providing a piece of flexible tubing, the tubing comprising a single piece and having no adhesives on the interior surfaces;
providing a support device for the flexible tubing, the support device being configured to prevent flow constricting areas from forming in the flexible tubing;
and transporting a fluid through the flexible tubing.
38. A kink-resistant tubing apparatus comprising a support structure, said support structure being configured to substantially prevent kinking in a weight bearing flexible tube disposed within said support structure.
39. A kink-resistant tubing apparatus comprising a support structure, said support structure being configured to substantially prevent kinking in a weight bearing flexible tube disposed within said support structure, and said support structure being configured so that said flexible tubing is adjustable within said support structure.
40. A kink-resistant tubing apparatus comprising a support structure, said support structure being configured to be weight bearing to substantially prevent kinking in a flexible tube disposed within said support structure when weight is applied to said flexible tube.
41. A kink-resistant tubing apparatus comprising a support structure, said support structure being configured to substantially prevent kinking in a flexible tube disposed within said support structure when weight is applied to said flexible tube, and said support structure being configured so that said flexible tubing is adjustable within said support structure.
42. A kink-resistant tubing apparatus which is weight bearing.
43. An adjustable kink-resistant tubing apparatus which is weight bearing.
44. A biological fluid filtration system comprising:
a blood container;
a leukocyte depletion device, said leukocyte depletion device having an inlet and an outlet with a filter media disposed therebetween, said leukocyte depletion device being disposed downstream from said blood container;
a first conduit, said blood container and said inlet of said leukocyte depletion device being in fluid communication through said first conduit;
a blood-receiving container, said blood receiving container being disposed downstream of said leukocyte depletion device;
a second conduit, said outlet of said leukocyte depletion device being in fluid communication with said blood receiving bag through said second conduit;
a bypass line, said bypass line providing fluid communication between said. blood container and said blood receiving container;
said bypass line comprising a loop, said loop of said bypass line being configured to be disposed above said blood container at a sufficient height to prevent the passage of fluid around the leukocyte depletion device; and a tube support device, said loop of said bypass line being disposed in said tube support device, and said tube support device being configured to support substantially the entire weight of said biological fluid filtration system without substantially crimping said bypass line.
a blood container;
a leukocyte depletion device, said leukocyte depletion device having an inlet and an outlet with a filter media disposed therebetween, said leukocyte depletion device being disposed downstream from said blood container;
a first conduit, said blood container and said inlet of said leukocyte depletion device being in fluid communication through said first conduit;
a blood-receiving container, said blood receiving container being disposed downstream of said leukocyte depletion device;
a second conduit, said outlet of said leukocyte depletion device being in fluid communication with said blood receiving bag through said second conduit;
a bypass line, said bypass line providing fluid communication between said. blood container and said blood receiving container;
said bypass line comprising a loop, said loop of said bypass line being configured to be disposed above said blood container at a sufficient height to prevent the passage of fluid around the leukocyte depletion device; and a tube support device, said loop of said bypass line being disposed in said tube support device, and said tube support device being configured to support substantially the entire weight of said biological fluid filtration system without substantially crimping said bypass line.
45. The biological fluid filtration system according to claim 44, wherein said bypass line connects to the top of said blood bag.
46. The biological fluid filtration system according to claim 44, wherein said bypass line connects to the bottom of said blood bag.
47. The biological fluid filtration system according to claim 44, wherein said tube support device comprises:
a tube support comprising a curvilinear channel disposed therein for receiving a piece of tubing; and means for holding a piece of tubing in said channel.
a tube support comprising a curvilinear channel disposed therein for receiving a piece of tubing; and means for holding a piece of tubing in said channel.
48. The biological fluid filtration system according to claim 44, wherein said tube support device comprises:
a tube support comprising a curvilinear channel disposed therein for receiving a piece of tubing; and structure to hold a piece of flexible tubing in said channel.
a tube support comprising a curvilinear channel disposed therein for receiving a piece of tubing; and structure to hold a piece of flexible tubing in said channel.
49. A kink resistant tubing apparatus comprising a support member, said support member comprising:
at least two channels through said support member for retaining tubing; and structure to support the weight of said tubing apparatus without substantially deforming tubing retained by said support member.
at least two channels through said support member for retaining tubing; and structure to support the weight of said tubing apparatus without substantially deforming tubing retained by said support member.
50. The kink resistant tubing apparatus according to claim 49, wherein said at least two channels are substantially parallel to each other.
51. The kink resistant tubing apparatus according to claim 50, wherein said support member is substantially rectangular.
59. A weight bearing tubing device for transporting fluids comprising:
a support member, said support member comprising:
a curvilinear channel formed therein for receiving a tube; and an adhesive disposed in said channel for securing a tubing into the channel.
60. The tubing device according to claim 59, further comprising a flexible tube, said flexible tube being disposed in said channel of said support member.
61. The tubing device according to claim 60, wherein said support member comprises an aperture for hanging said tubing device.
62. The tubing device according to claim 60, wherein said curvilinear channel comprises at least one of: a "U" bend, a right angle bend and a straight section.
63. The tubing device according to claim 60, wherein the interior of said tubing is free of adhesives.
64. The tubing device according to claim 60, wherein said channel has a substantially semi-circular cross section.
65. The tubing device according to claim 60, wherein said channel has a cross section which comprises an arc which is greater than a semi-circle.
66. The tubing device according to claim 65, wherein said tubing is held in said channel of said support device by the greater than semi-circular cross section of said channel.
67. The tubing device according to claim 65, wherein said channel comprises an opening to allow a tube to be inserted into said channel, and said opening is less than the outer diameter of said tubing.
68. The tubing device according to claim 60, wherein the outer diameter of said tubing is substantially equal to the inner diameter of said channel.
69. The tubing device according to claim 60, wherein said channel comprises a "U"-bend, and the legs of said U-bend are oriented substantially perpendicular to the direction the tubing device is designed to hang, to prevent the gravitational forces acting on the device deforming the "U"-shape into a "V"-shape.
70. The tubing device according to claim 59, wherein said curvilinear channel is a first curvilinear channel, and said support member comprises a second curvilinear channel, said second curvilinear channel being disposed adjacent to said first curvilinear channel and within said support member.
71. A weight bearing tubing device for use in the medical industry, said tubing device comprising:
a tube support comprising a curvilinear channel disposed therein for receiving a piece of tubing; and means for holding a piece of tubing in said channel.
72. The tubing device according to claim 71, wherein said means for holding comprises adhesive.
73. The tubing device according to claim 71, wherein said channel has a semi-circular cross-section.
74. The tubing device according to claim 71, wherein said channel has a cross-section with a greater than semi-circular cross-section.
75. The tubing device according to claim 74, wherein said means for holding comprises said greater than semi-circular cross-section.
76. A weight bearing tubing device for transporting a biological fluid, said tubing device comprising:
a tube support comprising a curvilinear channel disposed therein for receiving a piece of tubing; and structure to hold a piece of flexible tubing in said channel.
59. A weight bearing tubing device for transporting fluids comprising:
a support member, said support member comprising:
a curvilinear channel formed therein for receiving a tube; and an adhesive disposed in said channel for securing a tubing into the channel.
60. The tubing device according to claim 59, further comprising a flexible tube, said flexible tube being disposed in said channel of said support member.
61. The tubing device according to claim 60, wherein said support member comprises an aperture for hanging said tubing device.
62. The tubing device according to claim 60, wherein said curvilinear channel comprises at least one of: a "U" bend, a right angle bend and a straight section.
63. The tubing device according to claim 60, wherein the interior of said tubing is free of adhesives.
64. The tubing device according to claim 60, wherein said channel has a substantially semi-circular cross section.
65. The tubing device according to claim 60, wherein said channel has a cross section which comprises an arc which is greater than a semi-circle.
66. The tubing device according to claim 65, wherein said tubing is held in said channel of said support device by the greater than semi-circular cross section of said channel.
67. The tubing device according to claim 65, wherein said channel comprises an opening to allow a tube to be inserted into said channel, and said opening is less than the outer diameter of said tubing.
68. The tubing device according to claim 60, wherein the outer diameter of said tubing is substantially equal to the inner diameter of said channel.
69. The tubing device according to claim 60, wherein said channel comprises a "U"-bend, and the legs of said U-bend are oriented substantially perpendicular to the direction the tubing device is designed to hang, to prevent the gravitational forces acting on the device deforming the "U"-shape into a "V"-shape.
70. The tubing device according to claim 59, wherein said curvilinear channel is a first curvilinear channel, and said support member comprises a second curvilinear channel, said second curvilinear channel being disposed adjacent to said first curvilinear channel and within said support member.
71. A weight bearing tubing device for use in the medical industry, said tubing device comprising:
a tube support comprising a curvilinear channel disposed therein for receiving a piece of tubing; and means for holding a piece of tubing in said channel.
72. The tubing device according to claim 71, wherein said means for holding comprises adhesive.
73. The tubing device according to claim 71, wherein said channel has a semi-circular cross-section.
74. The tubing device according to claim 71, wherein said channel has a cross-section with a greater than semi-circular cross-section.
75. The tubing device according to claim 74, wherein said means for holding comprises said greater than semi-circular cross-section.
76. A weight bearing tubing device for transporting a biological fluid, said tubing device comprising:
a tube support comprising a curvilinear channel disposed therein for receiving a piece of tubing; and structure to hold a piece of flexible tubing in said channel.
52. The kink resistant tubing apparatus according to claim 51, wherein said structure to support the weight of said tubing apparatus comprises a hole through said support member.
53. The kink resistant tubing apparatus according to claim 51, wherein said hole through said support structure is substantially perpendicular to said at least two channels.
54. The kink resistant tubing apparatus according to claim 50, wherein said support member comprises a curved portion between said at least two channels.
55. The kink resistant tubing apparatus according to claim 54, wherein said structure to support the weight of said tubing apparatus comprises said curved portion of said support member.
56. The kink resistant tubing apparatus according to claim 49, wherein said support member is configured to prevent deformation of tubing held by said support member upon the weight of said tubing apparatus being supported by said support member.
57. The kink resistant tubing apparatus according to claim 49, wherein said support member is flexible.
58. The kink resistant tubing apparatus according to claim 49, wherein said support member is substantially rigid.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2771046A CA2771046C (en) | 2001-01-31 | 2002-01-31 | Device for transporting fluids |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26556001P | 2001-01-31 | 2001-01-31 | |
US60/265,560 | 2001-01-31 | ||
PCT/US2002/003098 WO2002061318A1 (en) | 2001-01-31 | 2002-01-31 | Multi-purpose tubing apparatus |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2771046A Division CA2771046C (en) | 2001-01-31 | 2002-01-31 | Device for transporting fluids |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2437057A1 true CA2437057A1 (en) | 2002-08-08 |
CA2437057C CA2437057C (en) | 2012-04-24 |
Family
ID=23010962
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2771046A Expired - Fee Related CA2771046C (en) | 2001-01-31 | 2002-01-31 | Device for transporting fluids |
CA2437057A Expired - Fee Related CA2437057C (en) | 2001-01-31 | 2002-01-31 | Biological fluid filtration system |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2771046A Expired - Fee Related CA2771046C (en) | 2001-01-31 | 2002-01-31 | Device for transporting fluids |
Country Status (6)
Country | Link |
---|---|
US (5) | US7571744B2 (en) |
EP (1) | EP1364146B1 (en) |
JP (2) | JP4885417B2 (en) |
AU (3) | AU2002243793B2 (en) |
CA (2) | CA2771046C (en) |
WO (1) | WO2002061318A1 (en) |
Cited By (1)
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US8640738B2 (en) | 2001-01-31 | 2014-02-04 | Haemonetics Corporation | Multi-purpose tubing apparatus |
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- 2002-01-31 WO PCT/US2002/003098 patent/WO2002061318A1/en active IP Right Grant
- 2002-01-31 JP JP2002561229A patent/JP4885417B2/en not_active Expired - Fee Related
- 2002-01-31 CA CA2437057A patent/CA2437057C/en not_active Expired - Fee Related
- 2002-01-31 US US10/066,515 patent/US7571744B2/en not_active Expired - Fee Related
- 2002-01-31 EP EP02709301A patent/EP1364146B1/en not_active Expired - Lifetime
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2006
- 2006-03-31 US US11/395,662 patent/US7686797B2/en not_active Expired - Fee Related
-
2007
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- 2007-10-31 US US11/931,525 patent/US8092413B2/en not_active Expired - Fee Related
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2008
- 2008-08-19 JP JP2008210699A patent/JP5053205B2/en not_active Expired - Fee Related
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2009
- 2009-04-24 AU AU2009201643A patent/AU2009201643B2/en not_active Ceased
- 2009-07-13 US US12/501,552 patent/US8640738B2/en not_active Expired - Fee Related
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- 2010-01-13 US US12/638,761 patent/US8262640B2/en not_active Expired - Fee Related
Cited By (1)
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US8640738B2 (en) | 2001-01-31 | 2014-02-04 | Haemonetics Corporation | Multi-purpose tubing apparatus |
Also Published As
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AU2007202821A1 (en) | 2007-07-12 |
CA2771046C (en) | 2013-11-12 |
JP5053205B2 (en) | 2012-10-17 |
AU2009201643B2 (en) | 2012-11-15 |
CA2437057C (en) | 2012-04-24 |
US20090270837A1 (en) | 2009-10-29 |
US20080058714A1 (en) | 2008-03-06 |
AU2009201643A1 (en) | 2009-05-21 |
WO2002061318A1 (en) | 2002-08-08 |
US20020120224A1 (en) | 2002-08-29 |
JP2009006159A (en) | 2009-01-15 |
US8262640B2 (en) | 2012-09-11 |
EP1364146A1 (en) | 2003-11-26 |
AU2002243793B2 (en) | 2007-03-15 |
CA2771046A1 (en) | 2002-08-08 |
US20100108592A1 (en) | 2010-05-06 |
US7686797B2 (en) | 2010-03-30 |
US8640738B2 (en) | 2014-02-04 |
US7571744B2 (en) | 2009-08-11 |
JP4885417B2 (en) | 2012-02-29 |
US8092413B2 (en) | 2012-01-10 |
US20060178613A1 (en) | 2006-08-10 |
JP2004528067A (en) | 2004-09-16 |
EP1364146B1 (en) | 2012-06-20 |
EP1364146A4 (en) | 2008-07-30 |
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