CA2445356A1 - Biocompatible scaffolds for ligament or tendon repair - Google Patents
Biocompatible scaffolds for ligament or tendon repair Download PDFInfo
- Publication number
- CA2445356A1 CA2445356A1 CA002445356A CA2445356A CA2445356A1 CA 2445356 A1 CA2445356 A1 CA 2445356A1 CA 002445356 A CA002445356 A CA 002445356A CA 2445356 A CA2445356 A CA 2445356A CA 2445356 A1 CA2445356 A1 CA 2445356A1
- Authority
- CA
- Canada
- Prior art keywords
- implant
- scaffold
- tissue
- ligament
- biocompatible
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/3662—Ligaments, tendons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/08—Muscles; Tendons; Ligaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/10—Materials or treatment for tissue regeneration for reconstruction of tendons or ligaments
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Rehabilitation Therapy (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
A biocompatible ligament repair implant or scaffold device is provided for use in repairing a variety of ligament tissue injuries. The repair procedures may be conducted with ligament repair implants that contain a biological component that assists in healing or tissue repair. The biocompatible ligament repair implants include a biocompatible scaffold and particles of viable tissue derived from ligament tissue or tendon tissue, such that the tissue and the scaffold become associated. The particles of living tissue contain one or more viable cells that can migrate from the tissue and populate the scaffold.
Claims (32)
1. A tendon or ligament repair implant, comprising:
a biocompatible scaffold having an aspect ratio greater than 1; and at least one minced tissue particle, derived from ligament tissue or tendon tissue, that is associated with at least a portion of the scaffold.
a biocompatible scaffold having an aspect ratio greater than 1; and at least one minced tissue particle, derived from ligament tissue or tendon tissue, that is associated with at least a portion of the scaffold.
2. The implant of claim l, wherein the scaffold has a cylindrical shape or an elliptical shape.
3. The implant of claim 1, wherein the aspect ratio of the scaffold is in the range of about greater than 2 and less than 100.
4. The implant of claim 1, wherein the scaffold is made from a copolymer of 95:5 lactide and glycolide.
5. The implant of claim 1, wherein the scaffold is made from polymers or copolymers formed from monomers selected from the group consisting of lactide, glycolide, dioxanone, and caprolactone.
6. The implant of claim 1, wherein the implant includes natural polymers selected from the group consisting of collagen, fibrin, and silk.
7. The implant of claim 2, wherein the implant includes strips of collagen or silk present within an inner portion of the scaffold or on a peripheral portion of the scaffold.
The implant of claim l, wherein the scaffold has a diameter in the range of about 3 to 12 mm.
9. The implant of claim 1, wherein the scaffold has a tensile strength and an elastic modulus similar to that of native tendon or ligament tissue.
10. The implant of claim 9, wherein the tensile strength of the scaffold is in the range of about 1000N to 2500N.
11. The implant of claim 9, wherein the elastic modulus of the scaffold is in the range of about 150N/m to 200N/m.
12. The implant of claim 1, wherein the scaffold has a slow resorption profile.
13. The implant of claim 12, wherein the resorption profile of the scaffold spans at least three months.
14. The implant of claim 1, wherein the scaffold is formed from a foam component reinforced with a mesh component.
15. The implant of claim 14, wherein the mesh component includes polydioxanone and the foam component is a copolymer of35:65 .epsilon.-caprolactone and glycolide.
16. The implant of claim 14, wherein the scaffold has an open pore structure with pores having a size sufficient to allow cell and tissue ingrowth.
17. The implant of claim 16, wherein the pores have an average diameter in the range of about 50 to 1000 microns.
18. The implant of claim 14, wherein the foam component has a thickness in the range of about 300 microns to 2 mm.
19. The implant of claim 14, wherein the mesh component has a mesh density in the range of about 12% to 80%.
20. The implant of claim l, wherein the scaffold is formed of plurality of filaments.
21. The implant of claim 20, wherein the majority of fibers that form the filaments are aligned in a longitudinal direction.
22. The implant of claim 1, wherein the scaffold is formed from a material selected from the group consisting of a knit material, a woven material, and a braided material.
23. The implant of claim 14, wherein the mesh is formed on the outer surface of the scaffold.
24. The implant of claim 22, wherein the mesh is a knit or a woven structure,
25. The implant of claim 22, wherein the mesh is biodegradable and biocompatible.
26. The implant of claim 1, further comprising an autograft selected from the group consisting of ligament tissue, bone-patellar tendons, tendon-bone tendons, hamstring tendons, or iliotibial band.
27. The implant of claim 26, wherein the implant and the autograft are configured in an orientation selected from the group consisting of the implant being placed around the autograft, the implant being surrounded by the autograft, and the implant being placed alongside the autograft.
28. The implant of claim 1, wherein the biocompatible scaffold further comprises at least one additional biological component applied thereto.
29. The implant of claim 28, wherein the at least one additional biological component comprises growth factors, matrix proteins, peptides, antibodies, enzymes, cytokines, viruses, nucleic acids, peptides, isolated cells, platelets, and combinations thereof.
30. The implant of claim l, wherein the biocompatible scaffold further comprises an adhesion agent for anchoring the suspension of tissue fragment to the biocompatible scaffold.
31. The implant of claim 30, wherein the adhesion agent comprises an anchoring agent selected from the group consisting of hyaluronic acid, fibrin glue, fibrin clot, collagen gel, gelatin-resorcin-formalin adhesive, mussel-based adhesive, dihydroxyphenylalanine (DOPA) based adhesive, chitosan, transglutaminase, poly(amino acid)-based adhesive, cellulose-based adhesive, synthetic acrylate-based adhesives, platelet rich plasma (PRP), Matrigel, Monostearoyl Glycerol co-Succinate (MGSA), Monostearoyl Glycerol co-Succinate/polyethylene glycol (MGSA/l?EG) copolymers, laminin, elastin, proteoglycans, and combinations thereof.
32. The implant of claim 30, wherein the adhesion agent comprises a cross-linking agent selected from the group consisting of divinyl sulfone (DVS), polyethylene glycon divinyl sulfone (VS-PEG-VS), hydroxyethyl methacrylate divinyl sulfone (HEMA-DIS-HEMA), formaldehyde, glutaraldehyde, aldehydes, isocyanates, alkyl and aryl halides, imidoesters, N-substituted maleimides, acylating compounds, carbodiimide, hydroxychloride, N-hydroxysuccinimide, light, pH, temperature, and combinations thereof.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41953902P | 2002-10-18 | 2002-10-18 | |
US42009302P | 2002-10-18 | 2002-10-18 | |
US60/420,093 | 2002-10-18 | ||
US60/419,539 | 2002-10-18 | ||
US10/374,754 | 2003-02-25 | ||
US10/374,754 US7824701B2 (en) | 2002-10-18 | 2003-02-25 | Biocompatible scaffold for ligament or tendon repair |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2445356A1 true CA2445356A1 (en) | 2004-04-18 |
CA2445356C CA2445356C (en) | 2010-02-02 |
Family
ID=32045863
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002445356A Expired - Fee Related CA2445356C (en) | 2002-10-18 | 2003-10-17 | Biocompatible scaffolds for ligament or tendon repair |
Country Status (6)
Country | Link |
---|---|
US (2) | US7824701B2 (en) |
EP (1) | EP1410810B1 (en) |
JP (1) | JP4623954B2 (en) |
AU (1) | AU2003252882B2 (en) |
CA (1) | CA2445356C (en) |
DE (1) | DE60311379T2 (en) |
Cited By (8)
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US8518433B2 (en) | 2003-12-11 | 2013-08-27 | Zimmer, Inc. | Method of treating an osteochondral defect |
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US9138318B2 (en) | 2007-04-12 | 2015-09-22 | Zimmer, Inc. | Apparatus for forming an implant |
US10167447B2 (en) | 2012-12-21 | 2019-01-01 | Zimmer, Inc. | Supports and methods for promoting integration of cartilage tissue explants |
US10179191B2 (en) | 2014-10-09 | 2019-01-15 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
US10245306B2 (en) | 2012-11-16 | 2019-04-02 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
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CA2445356C (en) | 2010-02-02 |
JP2004136097A (en) | 2004-05-13 |
US7824701B2 (en) | 2010-11-02 |
US20110009963A1 (en) | 2011-01-13 |
JP4623954B2 (en) | 2011-02-02 |
US20040078077A1 (en) | 2004-04-22 |
DE60311379D1 (en) | 2007-03-15 |
EP1410810B1 (en) | 2007-01-24 |
AU2003252882A1 (en) | 2004-05-06 |
US8637066B2 (en) | 2014-01-28 |
EP1410810A1 (en) | 2004-04-21 |
AU2003252882B2 (en) | 2006-07-06 |
DE60311379T2 (en) | 2007-11-08 |
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