CA2445654A1 - Anastomosis devices and methods for treating anastomotic sites - Google Patents

Anastomosis devices and methods for treating anastomotic sites Download PDF

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Publication number
CA2445654A1
CA2445654A1 CA002445654A CA2445654A CA2445654A1 CA 2445654 A1 CA2445654 A1 CA 2445654A1 CA 002445654 A CA002445654 A CA 002445654A CA 2445654 A CA2445654 A CA 2445654A CA 2445654 A1 CA2445654 A1 CA 2445654A1
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living organism
substantially tubular
tubular organs
organism according
joining
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CA002445654A
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French (fr)
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CA2445654C (en
Inventor
Kevin Weadock
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Cordis Corp
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Cordis Corp
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    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/0097—Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated

Abstract

Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reacti on to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.</S DOAB>

Claims (40)

1, An apparatus for joining substantially tubular organs in a living organism, comprising:
an anastomosis device for connecting a graft vessel to a target vessel such that the two vessels are in fluid communication; and at least one agent in therapeutic dosages incorporated into the graft vessel for treatment of reactions by the living organism.
2. The apparatus for joining substantially tubular organs in a living organism according to Claim 1, wherein the anastomosis device comprises a flange and a plurality of fastener members.
3. The apparatus for joining substantially tubular organs in a living organism according to Claim 1, wherein the anastomosis device comprises a surgical clip for sealingly connecting the graft vessel to the target vessel.
4. The apparatus for joining substantially tubular organs in a living organism according to Claim 3, wherein the surgical clip comprises a holding device which penetrates the graft and target vessel walls and sealingly joins them when crimped.
5. The apparatus for joining substantially tubular organs in a living organism according to Claim 1, wherein the graft vessel comprises an autograft.
6. The apparatus for joining substantially tubular organs in a living organism according to Claim 1, wherein the graft vessel comprises a homograft.
7. The apparatus for joining substantially tubular organs in a living organism according to Claim 1, wherein the graft vessel comprises a xenograft.
8. The apparatus for joining substantially tubular organs in a living organism according to Claim 1, wherein the graft vessel comprises a synthetic material.
9. The apparatus for joining substantially tubular organs in a living organism according to Claim 8, wherein the synthetic material comprises a polymer.
10. The apparatus for joining substantially tubular organs in a living organism according to Claim 1, wherein the at least one agent comprises an anti-proliferative.
11. The apparatus for joining substantially tubular organs in a living organism according to Claim 1, wherein the at least one agent comprises an anti-inflammatory.
12. The apparatus for joining substantially tubular organs in a living organism according to Claim 1, wherein the at least one agent comprises an anti-coagulant.
13. The apparatus for joining substantially tubular organs in a living organism according to Claim 1, wherein the at least one agent comprises rapamycin.
14. The apparatus for joining substantially tubular organs in a living organism according to Claim 1, wherein the at least one agent comprises heparin.
15. An apparatus for joining substantially tubular organs in a living organism, comprising:

an anastomosis device for connecting a graft vessel to a target vessel such that the two vessels are in fluid communication;
a biocompatible vehicle affixed to at least a portion of the graft vessel; and at least one agent in therapeutic dosages incorporated into the biocompatible vehicle for the treatment of reactions by the living organism caused by the anastomosis device or the implantation thereof.
16. The apparatus for joining substantially tubular organs in a living organism according to Claim 15, wherein the anastomosis device comprises a flange and a plurality of fastener members.
17. The apparatus for joining substantially tubular organs in a living organism according to Claim 15, wherein the anastomosis device comprises a surgical clip for sealingly connecting the graft vessel to the target vessel.
18. The apparatus for joining substantially tubular organs in a living organism according to Claim 17, wherein the surgical clip comprises a holding device which penetrates the graft and target vessel walls and sealingly joins them when crimped.
19. The apparatus for joining substantially tubular organs in a living organism according to Claim 15, wherein the biocompatible material comprises a polymeric matrix.
20. The apparatus for joining substantially tubular organs in a living organism according to Claim 16, wherein the biocompatible vehicle comprises a polyfluoro copolymer comprising polymerized residue of a first moiety selected from the group consisting of vinylidenefluoride and tetrafluoroethylene, and polymerized residue of a second moiety other than the first moiety and which is copolymerized with the first moiety, thereby producing the polyfluoro copolymer, wherein the relative amounts of the polymerized residue of the first moiety and the polymerized residue of the second moiety are effective to produce the biocompatible coating with properties effective for use in coating implantable medical devices when the coated medical device is subjected to a predetermined maximum temperature, and a solvent in which the polyfluoro copolymer is substantially soluble.
21. The apparatus for joining substantially tubular organs in a living organism according to Claim 20, wherein the polyfluoro copolymer comprises from about 50 to about 92 weight percent of the polymerized residue of the first moiety copolymerized with from about 50 to about 3 weight percent of the polymerized residue of the second moiety.
22. The apparatus for joining substantially tubular organs in a living organism according to Claim 20, wherein said polyfluoro copolymer comprises from about 50 to about 85 weight percent of the polymerized residue of vinylidenefluoride copolymerized with from about 50 to about 15 weight percent of the polymerized residue of the second moiety.
23. The apparatus for joining substantially tubular organs in a living organism according to Claim 20, wherein said copolymer comprises from about 55 to about 65 weight percent of the polymerized residue of the vinylidenefluoride copolymerized with from about 45 to about 35 weight percent of the polymerized residue of the second moiety.
24. The apparatus for joining substantially tubular organs in a living organism according to Claim 20, wherein the second moiety is selected from the group consisting of hexafluoropropylene, tetrafluoroethylene, vinylidenefluoride, 1-hydropentafluoropropylene, perfluoro (methyl vinyl ether), chlorotrifluoroethylene, pentafluoropropene, trifluoroethylene, hexafluoroacetone and hexafluoroisobutylene.
25. The apparatus for joining substantially tubular organs in a living organism according to Claim 20, wherein the second moiety is hexafluoropropylene.
26. The apparatus for joining substantially tubular organs in a living organism according to Claim 15, wherein the at least one agent comprises an anti-proliferative.
27. The apparatus for joining substantially tubular organs in a living organism according to Claim 15, wherein the at least one agent comprises an anti-inflammatory.
28. The apparatus for joining substantially tubular organs in a living organism according to Claim 15, wherein the at least one agent comprises an anti-coagulant.
29. The apparatus for joining substantially tubular organs in a living organism according to Claim 15, wherein the at least one agent comprises rapamycin.
30. The apparatus for joining substantially tubular organs in a living organism according to Claim 15, wherein the at least one agent comprises heparin.
31. An apparatus for joining substantially tubular organs in a living organism, comprising:
a device for connecting a graft vessel to a target vessel such that the two vessels are in fluid communication;
a cuff positioned around the graft vessel proximate to where the graft vessel is connected to the target vessel; and at least one agent in therapeutic dosages incorporated into the cuff for treatment of reactions by the living organism caused by the device or the implantation thereof.
32. The apparatus for joining substantially tubular organs in a living organism according to Claim 31, wherein the device comprises a flange and a plurality of fastener members.
33. The apparatus for joining substantially tubular organs in a living organism according to Claim 31, wherein the device comprises a surgical clip for sealingly connecting the graft vessel to the target vessel.
34. The apparatus for joining substantially tubular organs in a living organism according to Claim 33, wherein the surgical clip comprises a holding device which penetrates the graft and target vessel walls and sealingly joins them when crimped.
35. The apparatus for joining substantially tubular organs in a living organism according to Claim 31, wherein the cuff comprises a resorbable material.
36. The apparatus for joining substantially tubular organs in a living organism according to Claim 31, wherein the cuff comprises a non-resorbable material.
37. The apparatus for joining substantially tubular organs in a living organism according to Claim 31, wherein the at least one agent is incorporated directly into the cuff.
38. The apparatus for joining substantially tubular organs in a living organism according to Claim 31, wherein the at least one agent is incorporated into a biocompatible vehicle and the biocompatible material is affixed to the cuff.
39. The apparatus for joining substantially tubular organs in a living organism according to Claim 33, wherein the biocompatible vehicle comprises a polymeric matrix.

44. The apparatus for joining tissue in a living organism according to
Claim 40, wherein the second moiety is selected from the group consisting of hexafluoropropylene, tetrafluoroethylene, vinylidenefluoride, 1-hydropentafluoropropylene, perfluoro (methyl vinyl ether), chlorotrifluoroethylene, pentafluoropropene, trifluoroethylene, hexafluoroacetone and hexafluoroisobutylene.
45. The apparatus for joining tissue in a living organism according to Claim 40, wherein the second moiety is hexafluoropropylene.
46. The apparatus for joining tissue in a living organism according to Claim 31, wherein the at least one agent comprises an anti-proliferative.
47. The apparatus for joining tissue in a living organism according to Claim 31, wherein the at least one agent comprises an anti-inflammatory.
48. The apparatus for joining tissue in a living organism according to Claim 31, wherein the at least one agent comprises an anti-coagulant.
49. The apparatus for joining tissue in a living organism according to Claim 31, wherein the at least one agent comprises rapamycin.
50. The apparatus for joining tissue in a living organism according to Claim 31, wherein the at least one agent comprises heparin.
51. A method for the local treatment of an anastomotic site, comprising:
connecting a graft vessel to a target vessel such that the two vessels are in fluid communication; and delivering at least one agent in therapeutic dosages to at least one of the graft vessel or target vessel for treatment of reactions by a living organism caused by the connection of the graft vessel to the target vessel.

52. The method for the local treatment of an anastomotic site according to Claim 51, wherein the step of delivering at least one agent comprises affixing the at least one agent to the graft vessel.
53. The method for the local treatment of an anastomotic site according to Claim 51, wherein the step of delivering at least one agent comprises affixing a cuff containing the at least one agent to one of the graft vessel or target vessel.
54. The method for the local treatment of an anastomotic site according to Claim 51, wherein the step of delivering at least one agent comprises injecting the at least one agent into one of the graft vessel or target vessel.
55. The method for the local treatment of an anastomotic site according to Claim 51, wherein the step of delivering at least one agent comprises applying a gel containing the at least one agent to one of the graft vessel or target vessel.
56. An apparatus for joining substantially tubular organs in a living organism, comprising:
an anastomosis device for connecting a graft vessel to a target vessel such that the two vessels are in fluid communication; and at least one agent in therapeutic dosages incorporated into the graft vessel for treatment of reactions by the living organism caused by the anastomosis device or the implantation thereof.
CA2445654A 2002-10-21 2003-10-20 Anastomosis devices and methods for treating anastomotic sites Expired - Lifetime CA2445654C (en)

Applications Claiming Priority (2)

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US10/274,770 2002-10-21
US10/274,770 US20030065345A1 (en) 2001-09-28 2002-10-21 Anastomosis devices and methods for treating anastomotic sites

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CA2445654C CA2445654C (en) 2012-04-17

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EP (1) EP1421909B1 (en)
JP (1) JP4279114B2 (en)
AT (1) ATE442089T1 (en)
CA (1) CA2445654C (en)
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