CA2448902A1 - Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties - Google Patents
Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties Download PDFInfo
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- CA2448902A1 CA2448902A1 CA002448902A CA2448902A CA2448902A1 CA 2448902 A1 CA2448902 A1 CA 2448902A1 CA 002448902 A CA002448902 A CA 002448902A CA 2448902 A CA2448902 A CA 2448902A CA 2448902 A1 CA2448902 A1 CA 2448902A1
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- lancet
- lancing
- tissue
- profile
- phase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150106—Means for reducing pain or discomfort applied before puncturing; desensitising the skin at the location where body is to be pierced
- A61B5/15016—Means for reducing pain or discomfort applied before puncturing; desensitising the skin at the location where body is to be pierced by accessories for bringing the piercing element into the body, e.g. through rotation of the piercing element
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150167—Adjustable piercing speed of skin piercing element, e.g. blade, needle, lancet or canula, for example with varying spring force or pneumatic drive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
- A61B5/150427—Specific tip design, e.g. for improved penetration characteristics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
- A61B5/150435—Specific design of proximal end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150503—Single-ended needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
- A61B5/15123—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising magnets or solenoids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15126—Means for controlling the lancing movement, e.g. 2D- or 3D-shaped elements, tooth-shaped elements or sliding guides
- A61B5/1513—Means for controlling the lancing movement, e.g. 2D- or 3D-shaped elements, tooth-shaped elements or sliding guides comprising linear sliding guides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Optical Communication System (AREA)
- Cosmetics (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
A lancing device (42), an embodiment of which controls the advancement and retraction of a lancet (42) by monitoring the position of the lancet (42) in conjunction with a lancet (42) controller which incorporates a feedback loop for modulating the lancet driver (68) to follow a predetermined tissue lanci ng profile.
Claims (39)
1. A lancing device comprising:
a lancet comprising a shaft having a proximal driving end and a distal lancing end;
a lancet driver coupled to said lancet for longitudinal displacement of said lancet; and a lancet controller coupled to said lancet driver, said lancet controller comprising a feedback loop for monitoring the longitudinal displacement of said lancet and for modulating the lancet driver to provide a predetermined tissue lancing profile having characteristic phases for lancet advancement and retraction.
a lancet comprising a shaft having a proximal driving end and a distal lancing end;
a lancet driver coupled to said lancet for longitudinal displacement of said lancet; and a lancet controller coupled to said lancet driver, said lancet controller comprising a feedback loop for monitoring the longitudinal displacement of said lancet and for modulating the lancet driver to provide a predetermined tissue lancing profile having characteristic phases for lancet advancement and retraction.
2. A lancing device according to claim 1 wherein:
said lancet driver comprises a solenoid.
said lancet driver comprises a solenoid.
3. A lancing device according to claim 2 wherein:
said solenoid drives the lancet with electric current.
said solenoid drives the lancet with electric current.
4. A lancing device according to claim 3 wherein:
said lancet controller comprises additional coil segments disposed adjacent to said solenoid for monitoring the lancet displacement.
said lancet controller comprises additional coil segments disposed adjacent to said solenoid for monitoring the lancet displacement.
5. A lancing device according to claim 1 wherein:
said lancet driver comprises a means for oscillating the lancet to improve the lancet cutting ability.
said lancet driver comprises a means for oscillating the lancet to improve the lancet cutting ability.
6. A lancing device according to claim 5 wherein:
said oscillating means comprises a piezoelectric driver.
said oscillating means comprises a piezoelectric driver.
7. A lancing device according to claim 6 wherein:
said lancet controller controllably varies said tissue lancing profile as a function of impedance changes sensed from said piezoelectric driver resulting from said lancet interacting with said tissue.
said lancet controller controllably varies said tissue lancing profile as a function of impedance changes sensed from said piezoelectric driver resulting from said lancet interacting with said tissue.
8. A lancing device according to claim 5 wherein:
said lancet controller comprises a means for sensing a change in lancing pressure to determine the lancet displacement.
said lancet controller comprises a means for sensing a change in lancing pressure to determine the lancet displacement.
9. A lancing device according to claim 1 wherein:
said lancet controller comprises a processor for modulating the lancet driver.
said lancet controller comprises a processor for modulating the lancet driver.
10. A lancing device according to claim 9 wherein:
said processor comprises memory for storage and retrieval of a set of alternative lancing profiles which the processor uses to modulate the lancet driver.
said processor comprises memory for storage and retrieval of a set of alternative lancing profiles which the processor uses to modulate the lancet driver.
11. A lancing device according to claim 10 wherein:
a user of said lancing device selects the profile desired from said set of alternative profiles to modulate the lancet.
a user of said lancing device selects the profile desired from said set of alternative profiles to modulate the lancet.
12. A lancing device according to claim 9 wherein:
said processor optimizes said phases of said tissue lancing profile based on information entered by the user of said lancing device.
said processor optimizes said phases of said tissue lancing profile based on information entered by the user of said lancing device.
13. A lancing device according to claim 9 wherein:
said processor modulates the lancet driver by comparing an actual profile of the lancet to the profile and maintaining a preset error limit between the actual profile and the profile.
said processor modulates the lancet driver by comparing an actual profile of the lancet to the profile and maintaining a preset error limit between the actual profile and the profile.
14. A lancing device according to claim 9 wherein:
said processor comprises a database for the user.
said processor comprises a database for the user.
15. A lancing device according to claim 14 wherein:
said database allows the calculation of statistics for a profile.
said database allows the calculation of statistics for a profile.
16. A lancing device according to claim 9 or 14 wherein:
said processor comprises an internal clock which links the lancing event with a time stamp.
said processor comprises an internal clock which links the lancing event with a time stamp.
17. A lancing device according to claim 9 wherein:
said processor calculates an appropriate lancet diameter and geometry to collect a blood volume required by the user.
said processor calculates an appropriate lancet diameter and geometry to collect a blood volume required by the user.
18. A method for lancing tissue comprising the steps of:
selecting a desired profile from a set of alternative profiles having characteristic phases for lancet advancement and retraction;
lancing a user according to said profile;
determining a lancing profile trait during each of said characteristic phases; and optimizing said profile for subsequent lancing based upon said profile trait as a function of the characteristic phases for lancet advancement and retraction.
selecting a desired profile from a set of alternative profiles having characteristic phases for lancet advancement and retraction;
lancing a user according to said profile;
determining a lancing profile trait during each of said characteristic phases; and optimizing said profile for subsequent lancing based upon said profile trait as a function of the characteristic phases for lancet advancement and retraction.
19. A method for lancing tissue according to claim 18 wherein:
said profile trait comprises success of obtaining a blood sample from said user.
said profile trait comprises success of obtaining a blood sample from said user.
20. A method for lancing tissue according to claim 18 wherein:
said profile trait comprises blood volume obtained from said user.
said profile trait comprises blood volume obtained from said user.
21. A method for lancing tissue according to claim 18 wherein:
said profile trait comprises pain perceived by said user.
said profile trait comprises pain perceived by said user.
22. A method for lancing tissue according to claim 18 wherein:
said profile trait comprises a relative time associated with skin deformation.
said profile trait comprises a relative time associated with skin deformation.
23. A method for lancing tissue according to claim 18 wherein:
said profile trait comprises dwell time in said tissue of said user.
said profile trait comprises dwell time in said tissue of said user.
24. A method for lancing tissue comprising the steps of:
selecting a desired profile from a set of alternative profiles;
lancing a user according to said profile;
determining whether said lancing generated a blood sample result from said user;
determining whether said lancing had success of obtaining a blood sample from said user;
determining whether said lancing caused pain to said user;
storing said blood sample result, said blood volume, and said pain determinations; and optimizing said profile for subsequent lancing.
selecting a desired profile from a set of alternative profiles;
lancing a user according to said profile;
determining whether said lancing generated a blood sample result from said user;
determining whether said lancing had success of obtaining a blood sample from said user;
determining whether said lancing caused pain to said user;
storing said blood sample result, said blood volume, and said pain determinations; and optimizing said profile for subsequent lancing.
25. A method for lancing tissue according to claim 24 further comprising the step of:
prompting said user to choose between selecting another desired profile and selecting said optimized profile.
prompting said user to choose between selecting another desired profile and selecting said optimized profile.
26. A method for lancing tissue according to claim 24 further comprising the step of:
selecting a lancet diameter and geometry based on the optimizing of said profile.
selecting a lancet diameter and geometry based on the optimizing of said profile.
27. A method for lancing tissue according to claim 18, wherein:
said characteristic phases comprise a completed cycle of advancing and retracting said lancet into and out of a tissue to obtain a blood sample.
said characteristic phases comprise a completed cycle of advancing and retracting said lancet into and out of a tissue to obtain a blood sample.
28. A method for lancing tissue according to claim 18, wherein:
said characteristic phases further comprising:
a lancet introduction phase comprising a longitudinal advancement of the lancet in a first direction into said tissue;
a lancet rest phase comprising a termination of said longitudinal advancement of said lancet wherein said lancet reaches a maximum depth of tissue penetration and becomes relatively stationary; and a lancet retraction phase comprising a longitudinal retraction of said lancet in a second direction opposite said first direction out of said tissue.
said characteristic phases further comprising:
a lancet introduction phase comprising a longitudinal advancement of the lancet in a first direction into said tissue;
a lancet rest phase comprising a termination of said longitudinal advancement of said lancet wherein said lancet reaches a maximum depth of tissue penetration and becomes relatively stationary; and a lancet retraction phase comprising a longitudinal retraction of said lancet in a second direction opposite said first direction out of said tissue.
29. A method for lancing tissue according to claim 28, wherein:
said lancet introduction phase comprises a first time duration; and said lancet retraction phase comprises a second time duration which is relatively longer than said first time duration.
said lancet introduction phase comprises a first time duration; and said lancet retraction phase comprises a second time duration which is relatively longer than said first time duration.
30. A method for lancing tissue according to claim 28, wherein:
said lancet introduction phase further comprises:
a lancet launch phase comprising a longitudinal advancement of the lancet in said first direction from a stationary loaded lancing position toward the tissue;
a tissue contact phase including a point of initial contact between said distal end of said lancet and the tissue;
a tissue deformation phase comprising deforming said tissue while longitudinally advancing said lancet in said first direction;
a tissue lancing phase comprising penetrating said tissue while longitudinally advancing said lancet in said first direction;
said lancet introduction phase further comprises:
a lancet launch phase comprising a longitudinal advancement of the lancet in said first direction from a stationary loaded lancing position toward the tissue;
a tissue contact phase including a point of initial contact between said distal end of said lancet and the tissue;
a tissue deformation phase comprising deforming said tissue while longitudinally advancing said lancet in said first direction;
a tissue lancing phase comprising penetrating said tissue while longitudinally advancing said lancet in said first direction;
31. A method for lancing tissue according to claim 30, wherein:
said introduction phase varies according to said tissue deformation phase, such that said lancing follows said profile.
said introduction phase varies according to said tissue deformation phase, such that said lancing follows said profile.
32. A method for lancing tissue according to claim 30, wherein:
said introduction phase varies according to said tissue contact phase, such that said lancing follows said profile.
said introduction phase varies according to said tissue contact phase, such that said lancing follows said profile.
33. A method for lancing tissue according to claim 28, wherein:
said lancet retraction phase further comprises:
a primary lancet retraction phase comprising a longitudinal retraction of the lancet in said second direction from a relatively stationary position during said rest phase where said skin pushes said lancet in said second direction;
a secondary lancet retraction phase comprising a longitudinal retraction of the lancet in said second direction from said position where said skin stops pushing said lancet in said second direction to a position and said lancet is pulled out of said skin in said second direction;
and a lancet exit phase comprising a exit of the lancet from the shin.
said lancet retraction phase further comprises:
a primary lancet retraction phase comprising a longitudinal retraction of the lancet in said second direction from a relatively stationary position during said rest phase where said skin pushes said lancet in said second direction;
a secondary lancet retraction phase comprising a longitudinal retraction of the lancet in said second direction from said position where said skin stops pushing said lancet in said second direction to a position and said lancet is pulled out of said skin in said second direction;
and a lancet exit phase comprising a exit of the lancet from the shin.
34. A method for lancing tissue according to claim 33, wherein:
said retraction phase varies according to said primary retraction phase, such that said lancing follows said profile.
said retraction phase varies according to said primary retraction phase, such that said lancing follows said profile.
35. A method for lancing tissue according to claim 33, wherein:
said retraction phase varies according to said secondary retraction phase, such that said lancing follows said profile.
said retraction phase varies according to said secondary retraction phase, such that said lancing follows said profile.
36. A lancing device comprising:
means for lancing tissue to obtain a blood sample;
means for driving said lancing means; and means for controlling said driving means to provide a desired tissue lancing profile.
means for lancing tissue to obtain a blood sample;
means for driving said lancing means; and means for controlling said driving means to provide a desired tissue lancing profile.
37. A method for lancing tissue to obtain a blood sample comprising the steps of:
providing a lancet to puncture said tissue;
attaching said lancet to a lancet driver for advancement and retraction of said lancet; and controlling said lancet advancement and retraction by modulating said lancet driver to vary said advancement and retraction as a function of relative position and motion of said lancet.
providing a lancet to puncture said tissue;
attaching said lancet to a lancet driver for advancement and retraction of said lancet; and controlling said lancet advancement and retraction by modulating said lancet driver to vary said advancement and retraction as a function of relative position and motion of said lancet.
38. A lancing device according to claim 1 wherein:
said feedback loop further comprises a light detecting sensor and a light emitter for monitoring the relative position of said lancet, said lancet further comprising a reflective surface on said proximal end such that said light emitter emits light such that said light is reflected from said reflective surface to said sensor.
said feedback loop further comprises a light detecting sensor and a light emitter for monitoring the relative position of said lancet, said lancet further comprising a reflective surface on said proximal end such that said light emitter emits light such that said light is reflected from said reflective surface to said sensor.
39. A lancing device according to claim 1 wherein:
said feedback loop further comprises an electromagnetic sensor for monitoring the relative position of at least one magnetically permeable region disposed on a region of said shaft, said sensor comprising at least one solenoid.
said feedback loop further comprises an electromagnetic sensor for monitoring the relative position of at least one magnetically permeable region disposed on a region of said shaft, said sensor comprising at least one solenoid.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29800101P | 2001-06-12 | 2001-06-12 | |
US60/298,001 | 2001-06-12 | ||
PCT/US2002/019053 WO2002100251A2 (en) | 2001-06-12 | 2002-06-12 | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2448902A1 true CA2448902A1 (en) | 2002-12-19 |
CA2448902C CA2448902C (en) | 2010-09-07 |
Family
ID=23148571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2448902A Expired - Fee Related CA2448902C (en) | 2001-06-12 | 2002-06-12 | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
Country Status (9)
Country | Link |
---|---|
US (2) | US7316700B2 (en) |
EP (1) | EP1404233B1 (en) |
JP (2) | JP4209767B2 (en) |
AT (1) | ATE450210T1 (en) |
AU (1) | AU2002315177A1 (en) |
CA (1) | CA2448902C (en) |
DE (1) | DE60234598D1 (en) |
ES (1) | ES2336081T3 (en) |
WO (1) | WO2002100251A2 (en) |
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USD598126S1 (en) | 2008-06-06 | 2009-08-11 | Lifescan Scotland Limited | Electrochemical test strip |
US8551320B2 (en) | 2008-06-09 | 2013-10-08 | Lifescan, Inc. | System and method for measuring an analyte in a sample |
USD600812S1 (en) | 2008-06-10 | 2009-09-22 | Lifescan Scotland Limited | Analyte test strip port icon |
USD611151S1 (en) | 2008-06-10 | 2010-03-02 | Lifescan Scotland, Ltd. | Test meter |
CA2731031A1 (en) | 2008-07-18 | 2010-01-21 | Lifescan, Inc. | Analyte measurement and management device and associated methods |
USD600813S1 (en) | 2008-07-25 | 2009-09-22 | Lifescan, Inc. | Analyte test meter in a docking station |
USD600349S1 (en) | 2008-07-25 | 2009-09-15 | Lifescan, Inc. | Analyte test meter |
USD601258S1 (en) | 2008-07-25 | 2009-09-29 | Lifescan, Inc. | Analyte test meter docking station |
USD611489S1 (en) | 2008-07-25 | 2010-03-09 | Lifescan, Inc. | User interface display for a glucose meter |
CA2675227C (en) | 2008-08-15 | 2017-09-05 | Lifescan Scotland Limited | Analyte testing method and system |
USD611372S1 (en) | 2008-09-19 | 2010-03-09 | Lifescan Scotland Limited | Analyte test meter |
-
2002
- 2002-06-12 EP EP02742123A patent/EP1404233B1/en not_active Expired - Lifetime
- 2002-06-12 AU AU2002315177A patent/AU2002315177A1/en not_active Abandoned
- 2002-06-12 AT AT02742123T patent/ATE450210T1/en not_active IP Right Cessation
- 2002-06-12 ES ES02742123T patent/ES2336081T3/en not_active Expired - Lifetime
- 2002-06-12 US US10/220,828 patent/US7316700B2/en not_active Expired - Fee Related
- 2002-06-12 DE DE60234598T patent/DE60234598D1/en not_active Expired - Fee Related
- 2002-06-12 JP JP2003503081A patent/JP4209767B2/en not_active Expired - Fee Related
- 2002-06-12 CA CA2448902A patent/CA2448902C/en not_active Expired - Fee Related
- 2002-06-12 WO PCT/US2002/019053 patent/WO2002100251A2/en active Application Filing
-
2007
- 2007-05-03 US US11/744,063 patent/US7988645B2/en not_active Expired - Fee Related
-
2008
- 2008-09-09 JP JP2008230926A patent/JP5134475B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE450210T1 (en) | 2009-12-15 |
US20070239189A1 (en) | 2007-10-11 |
WO2002100251A3 (en) | 2003-08-21 |
EP1404233A2 (en) | 2004-04-07 |
JP5134475B2 (en) | 2013-01-30 |
CA2448902C (en) | 2010-09-07 |
DE60234598D1 (en) | 2010-01-14 |
ES2336081T3 (en) | 2010-04-08 |
US20030233112A1 (en) | 2003-12-18 |
JP2008289939A (en) | 2008-12-04 |
EP1404233B1 (en) | 2009-12-02 |
JP2005504564A (en) | 2005-02-17 |
WO2002100251A2 (en) | 2002-12-19 |
US7316700B2 (en) | 2008-01-08 |
JP4209767B2 (en) | 2009-01-14 |
US7988645B2 (en) | 2011-08-02 |
AU2002315177A1 (en) | 2002-12-23 |
EP1404233A4 (en) | 2007-05-30 |
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EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20170612 |