CA2449490A1 - System and method for milling materials - Google Patents

System and method for milling materials Download PDF

Info

Publication number
CA2449490A1
CA2449490A1 CA002449490A CA2449490A CA2449490A1 CA 2449490 A1 CA2449490 A1 CA 2449490A1 CA 002449490 A CA002449490 A CA 002449490A CA 2449490 A CA2449490 A CA 2449490A CA 2449490 A1 CA2449490 A1 CA 2449490A1
Authority
CA
Canada
Prior art keywords
milling
chamber
head
drive
milling chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002449490A
Other languages
French (fr)
Other versions
CA2449490C (en
Inventor
David Czekai
Robert G. Reed
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Pharma Ireland Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2449490A1 publication Critical patent/CA2449490A1/en
Application granted granted Critical
Publication of CA2449490C publication Critical patent/CA2449490C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C17/00—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
    • B02C17/18—Details
    • B02C17/24—Driving mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C17/00—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
    • B02C17/16—Mills in which a fixed container houses stirring means tumbling the charge
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T409/00—Gear cutting, milling, or planing
    • Y10T409/30—Milling

Abstract

A system for milling at least one material, e.g., a drug. The system include s a milling apparatus and at least one milling medium. The milling apparatus includes a chamber having a rotary milling head located in it. The milling head is rotated within the chamber by a magnetic drive system.

Claims (45)

1. A system for milling at least one material, said system comprising a milling apparatus and at least one milling medium for use therewith, said apparatus comprising a milling chamber, a milling head, and a drive member, said milling chamber comprising a hollow vessel for receipt of the at least one material and said at least one milling medium therein, said drive member including at least one drive magnet, said milling head being located within said milling chamber, being rotatably mounted with respect thereto and including at least one driven magnet, said at least one drive magnet being magnetically coupled to said at least one driven magnet, said drive member being arranged to be rotated by an energy source, whereupon rotation of said drive member effects the concomitant rotation of said milling head with respect to said milling chamber, said milling head cooperating with said at least one milling medium and with the at least one material to effect the milling of the at least one material within said milling chamber.
2. The system of Claim 1 wherein said milling chamber is removably mounted with respect to said drive member, whereupon said milling chamber and said milling head can be removed as a unit from said drive member.
3. The system of Claim 1 wherein said milling chamber includes a removable cover.
4. The system of Claim 2 wherein said milling chamber includes a removable cover.
5. The system of Claim 1 wherein said drive member is a shaft that is oriented vertically and is rotated by a motor.
6. The system of Claim 2 wherein said drive member is a shaft that is oriented vertically and is rotated by a motor.
7. The system of Claim 1 wherein said milling head includes at least one member projecting outward therefrom for cooperating with said milling medium and with the material to effect the milling of the at least one material within said milling chamber.
8. The system of Claim 7 wherein said milling head comprises a plurality of pegs projecting outward therefrom.
9. The system of Claim 1 additionally comprising at least one bearing rotatably mounting said milling head within said milling chamber.
10. The system of Claim 1 wherein said at least one drive magnet is a rare earth magnet.
11. The system of Claim 1 wherein said at least one driven magnet is a rare earth magnet.
12. The system of Claim 10 wherein said at least one driven magnet is a rare earth magnet.
13. The system of Claim 1 wherein said milling media comprise a plurality of small bodies.
14. The system of Claim 13 wherein said small bodies are approximately 500 microns in mean diameter or less.
15. The system of Claim 1 wherein said at least one milling media comprise polymeric material.
16. The system of Claim 13 wherein said at least one milling media comprise polymeric material.
17. The system of Claim 14 wherein said at least one milling media comprise polymeric material.
18. The system of Claim 1 wherein said drive member comprises a drive shaft having a first end portion, a longitudinal axis and wherein said at least one drive magnet is coupled to said drive shaft at said first end portion, said milling head having a central bore in which a portion of said milling chamber is located but spaced slightly therefrom, said at least one driven magnet being located adjacent said central bore, said drive shaft being arranged to be rotated about said longitudinal axis by the energy source, whereupon rotation of said drive shaft about said longitudinal axis effects the concomitant rotation of said milling head about said longitudinal axis.
19. The system of Claim 18 wherein said portion of said milling chamber comprises a spindle having a central well therein.
20. The system of Claim 19 wherein said first end portion of said drive shaft is located within said central well and wherein said at least one drive magnet is magnetically coupled to said at least one driven magnet via said spindle.
21. The system of Claim 18 wherein said milling chamber is removably mounted with respect to said drive shaft, whereupon said milling chamber and said milling head can be removed as a unit from said drive shaft.
22. The system of Claim 18 wherein said milling chamber includes a removable cover.
23. The system of Claim 21 wherein said milling chamber includes a removable cover.
24. The system of Claim 22 wherein said drive shaft is oriented vertically and the energy source is a motor to which said drive shaft is coupled.
25. The system of Claim 18 wherein said milling head includes at least one member projecting outward therefrom for cooperating with said milling medium and with the material to effect the milling of the at least one material within said milling chamber.
26. The system of Claim 25 wherein said milling head comprises a plurality of pegs projecting outward therefrom.
27. The system of Claim 20 wherein said milling head includes at least one member projecting outward therefrom for cooperating with said milling medium and with the material to effect the milling of the at least one material within said milling chamber.
28. The system of Claim 27 wherein said milling head comprises a plurality of pegs projecting outward therefrom.
29. The system of Claim 18 additionally comprising at least one bearing rotatably mounting said milling head on said portion of said milling chamber.
30. The system of Claim 19 additionally comprising at least one bearing rotatably mounting said milling head on said spindle.
31. The system of Claim 20 wherein said at least one drive magnet is a rare earth magnet.
32. The system of Claim 20 wherein said milling media comprise a plurality of small bodies.
33. The system of Claim 32 wherein said small bodies are approximately 500 microns in mean diameter or less.
34. The system of Claim 20 wherein said at least one milling media comprise polymeric material.
35. The system of Claim 33 wherein said at least one milling media comprise polymeric material.
36. The system of Claim 1 wherein the material is a drug.
37. The system of Claim 1 wherein the material is a diagnostic imaging agent.
38. A method for milling at least one material comprising:
(A) providing a milling chamber having a milling head located therein;~
(B) providing the at least one material in said milling chamber;
(C) providing at least one milling medium in said milling chamber;
(D) providing a shaft arranged to be rotated about a longitudinal axis by a source of energy; and (E) Magnetically coupling said shaft to said milling head to rotate said milling head about said axis in said milling chamber, whereupon rotation of said shaft about said axis effects the concomitant rotation of said milling head to effect the milling of the at least one material within said milling chamber.
39. The method of Claim 38 wherein said milling chamber is releasably mounted on said shaft, and wherein said method comprises removing said milling chamber and said milling head as a unit from said shaft.
40. The method of Claim 38 wherein said at least one milling medium comprises a plurality of small bodies.
41. The method of Claim 40 wherein said plurality of small bodies are approximately 500 microns in mean diameter or less.
42. The method of Claim 40 wherein said plurality of small bodies are formed of a polymeric material.
43. The method of Claim 41 wherein said plurality of small bodies are formed of a polymeric material.
44. The method of Claim 38 wherein the material is a drug.
45. The method of Claim 38 wherein the material is a diagnostic imaging agent.
CA2449490A 2001-06-05 2002-05-31 System and method for milling materials Expired - Lifetime CA2449490C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29596501P 2001-06-05 2001-06-05
US60/295,965 2001-06-05
PCT/US2002/017323 WO2002098565A1 (en) 2001-06-05 2002-05-31 System and method for milling materials

Publications (2)

Publication Number Publication Date
CA2449490A1 true CA2449490A1 (en) 2002-12-12
CA2449490C CA2449490C (en) 2010-10-05

Family

ID=23139990

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2449490A Expired - Lifetime CA2449490C (en) 2001-06-05 2002-05-31 System and method for milling materials

Country Status (12)

Country Link
US (3) US6742734B2 (en)
EP (1) EP1392441B1 (en)
JP (1) JP4223390B2 (en)
AT (1) ATE401959T1 (en)
AU (1) AU2002312230A1 (en)
CA (1) CA2449490C (en)
CY (1) CY1108429T1 (en)
DE (1) DE60227802D1 (en)
DK (1) DK1392441T3 (en)
ES (1) ES2309177T3 (en)
PT (1) PT1392441E (en)
WO (1) WO2002098565A1 (en)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080102121A1 (en) * 1998-11-02 2008-05-01 Elan Pharma International Limited Compositions comprising nanoparticulate meloxicam and controlled release hydrocodone
US6428814B1 (en) 1999-10-08 2002-08-06 Elan Pharma International Ltd. Bioadhesive nanoparticulate compositions having cationic surface stabilizers
US7198795B2 (en) 2000-09-21 2007-04-03 Elan Pharma International Ltd. In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions
US7998507B2 (en) 2000-09-21 2011-08-16 Elan Pharma International Ltd. Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors
US7276249B2 (en) 2002-05-24 2007-10-02 Elan Pharma International, Ltd. Nanoparticulate fibrate formulations
EP1339390A2 (en) * 2000-12-06 2003-09-03 Pharmacia Corporation Laboratory scale milling process
US6976647B2 (en) 2001-06-05 2005-12-20 Elan Pharma International, Limited System and method for milling materials
DE60227802D1 (en) * 2001-06-05 2008-09-04 Elan Pharma Int Ltd GRINDING MACHINE AND METHOD FOR THE OPERATION
US7758890B2 (en) 2001-06-23 2010-07-20 Lyotropic Therapeutics, Inc. Treatment using dantrolene
DE10141650C1 (en) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Safe transdermal therapeutic system for administration of fentanyl or analogous analgesics, having matrix layer of carboxy group-free polyacrylate adhesive providing high permeation rate
PT1471887E (en) 2002-02-04 2010-07-16 Elan Pharma Int Ltd Nanoparticulate compositions having lysozyme as a surface stabilizer
US9101540B2 (en) 2002-04-12 2015-08-11 Alkermes Pharma Ireland Limited Nanoparticulate megestrol formulations
US7101576B2 (en) 2002-04-12 2006-09-05 Elan Pharma International Limited Nanoparticulate megestrol formulations
JP4533134B2 (en) 2002-06-10 2010-09-01 エラン ファーマ インターナショナル，リミティド Nanoparticulate policosanol formulations and novel policosanol combinations
ES2355723T3 (en) 2002-09-11 2011-03-30 Elan Pharma International Limited COMPOSITIONS OF ACTIVE AGENT IN GAN STABILIZED NANOPARTICLES.
JP4469846B2 (en) 2003-01-31 2010-06-02 エラン ファーマ インターナショナル，リミティド Nanoparticulate topiramate formulation
US20100297252A1 (en) 2003-03-03 2010-11-25 Elan Pharma International Ltd. Nanoparticulate meloxicam formulations
US8512727B2 (en) 2003-03-03 2013-08-20 Alkermes Pharma Ireland Limited Nanoparticulate meloxicam formulations
US7140567B1 (en) * 2003-03-11 2006-11-28 Primet Precision Materials, Inc. Multi-carbide material manufacture and use as grinding media
JP2007501683A (en) 2003-05-22 2007-02-01 エラン ファーマ インターナショナル リミテッド Sterilization of nanoparticle active substance dispersions by gamma irradiation
CA2534924A1 (en) * 2003-08-08 2005-02-24 Elan Pharma International Ltd. Novel metaxalone compositions
US7879360B2 (en) 2003-11-05 2011-02-01 Elan Pharma International, Ltd. Nanoparticulate compositions having a peptide as a surface stabilizer
US7000850B2 (en) * 2004-04-27 2006-02-21 Brand New Technology Ltd. Anti-scald water valve assembly
US7910577B2 (en) 2004-11-16 2011-03-22 Elan Pharma International Limited Injectable nanoparticulate olanzapine formulations
UA89513C2 (en) * 2004-12-03 2010-02-10 Элан Фарма Интернешнл Лтд. Nanoparticulate raloxifene hydrochloride composition
CA2590675A1 (en) * 2004-12-15 2006-06-22 Elan Pharma International Ltd. Nanoparticulate tacrolimus formulations
US20060159767A1 (en) * 2004-12-22 2006-07-20 Elan Pharma International Limited Nanoparticulate bicalutamide formulations
CN101132770A (en) * 2005-01-06 2008-02-27 伊兰制药国际有限公司 Nanoparticulate candesartan formulations
CA2597716A1 (en) * 2005-02-15 2006-08-24 Elan Pharma International Limited Aerosol and injectable formulations of nanoparticulate benzodiazepine
JP2008531721A (en) * 2005-03-03 2008-08-14 エラン・ファルマ・インターナショナル・リミテッド Nanoparticulate compositions of heterocyclic amide derivatives
US20060204588A1 (en) * 2005-03-10 2006-09-14 Elan Pharma International Limited Formulations of a nanoparticulate finasteride, dutasteride or tamsulosin hydrochloride, and mixtures thereof
KR20070118258A (en) * 2005-03-16 2007-12-14 엘란 파마 인터내셔널 리미티드 Nanoparticulate leukotriene receptor antagonist/corticosteroid formulations
MX2007011495A (en) * 2005-03-17 2007-12-06 Elan Pharma Int Ltd Nanoparticulate biphosphonate compositions.
EA200702049A1 (en) 2005-03-23 2008-02-28 Элан Фарма Интернэшнл Лтд. COMPOSITIONS OF CORTICOSTEROID NANOPARTICLES WITH ANTIGISTAMINS
MX2007012778A (en) * 2005-04-12 2008-01-11 Elan Pharma Int Ltd Nanoparticulate quinazoline derivative formulations.
US20110064803A1 (en) * 2005-05-10 2011-03-17 Elan Pharma International Limited. Nanoparticulate and controlled release compositions comprising vitamin k2
BRPI0608771A2 (en) * 2005-05-10 2010-01-26 Elan Pharma Int Ltd nanoparticulate clopidogrel formulations
US20100028439A1 (en) * 2005-05-23 2010-02-04 Elan Pharma International Limited Nanoparticulate stabilized anti-hypertensive compositions
ES2341996T3 (en) * 2005-06-03 2010-06-30 Elan Pharma International Limited IMATINIB MESILATE FORMULATIONS IN THE FORM OF MANOPARTICLES.
CN101262860A (en) * 2005-06-03 2008-09-10 伊兰制药国际有限公司 Nanoparticulate acetaminophen formulations
US20070042049A1 (en) * 2005-06-03 2007-02-22 Elan Pharma International, Limited Nanoparticulate benidipine compositions
CA2612994A1 (en) 2005-06-08 2006-12-08 Elan Pharma International Limited Nanoparticulate and controlled release compositions comprising cefditoren
US20070059371A1 (en) * 2005-06-09 2007-03-15 Elan Pharma International, Limited Nanoparticulate ebastine formulations
MX2007015882A (en) * 2005-06-13 2008-03-04 Elan Pharma Int Ltd Nanoparticulate clopidogrel and aspirin combination formulations.
WO2006138421A2 (en) * 2005-06-15 2006-12-28 Elan Pharma International Limited Nanoparticulate azelnidipine formulations
EP1904041A2 (en) * 2005-07-07 2008-04-02 Elan Pharma International Limited Nanoparticulate clarithromycin formulations
EP1937217A2 (en) * 2005-09-13 2008-07-02 Elan Pharma International Limited Nanoparticulate tadalafil formulations
EP1933814A2 (en) 2005-09-15 2008-06-25 Elan Pharma International Limited Nanoparticulate aripiprazole formulations
EP1984344B1 (en) 2005-12-29 2012-09-26 Lexicon Pharmaceuticals, Inc. Multicyclic amino acid derivatives and methods of their use
US7649098B2 (en) 2006-02-24 2010-01-19 Lexicon Pharmaceuticals, Inc. Imidazole-based compounds, compositions comprising them and methods of their use
US8367112B2 (en) * 2006-02-28 2013-02-05 Alkermes Pharma Ireland Limited Nanoparticulate carverdilol formulations
NZ545960A (en) * 2006-03-15 2008-04-30 Environmental Decontamination Milling apparatus
JP2009538927A (en) * 2006-05-30 2009-11-12 エラン ファーマ インターナショナル，リミティド Nanoparticulate posaconazole formulation
CA2657379A1 (en) * 2006-07-10 2008-01-17 Elan Pharma International Ltd. Nanoparticulate sorafenib formulations
KR20090031618A (en) * 2006-07-12 2009-03-26 엘란 코포레이션, 피엘씨 Nanoparticulate formulations of modafinil
EP2124556B1 (en) 2006-10-09 2014-09-03 Charleston Laboratories, Inc. Pharmaceutical compositions
UA99270C2 (en) 2006-12-12 2012-08-10 Лексикон Фармасьютикалз, Инк. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
CN101730708B (en) 2007-03-28 2013-09-18 哈佛大学校长及研究员协会 Stitched polypeptides
EP2240022B1 (en) 2008-01-09 2016-12-28 Charleston Laboratories, Inc. Bilayered tablets comprising oxycodone and promethazine
US20090197780A1 (en) * 2008-02-01 2009-08-06 Weaver Jimmie D Ultrafine Grinding of Soft Materials
CA2715422A1 (en) * 2008-03-21 2009-09-24 Elan Pharma International Limited Compositions for site-specific delivery of imatinib and methods of use
CA2763456C (en) 2009-05-27 2017-10-24 Alkermes Pharma Ireland Limited Reduction of flake-like aggregation in nanoparticulate active agent compositions
EP2451274B1 (en) 2009-07-08 2017-10-04 Charleston Laboratories, Inc. Pharmaceutical compositions
CA2779681A1 (en) 2009-11-05 2011-05-12 Lexicon Pharmaceuticals, Inc. Tryptophan hydroxylase inhibitors for the treatment of cancer
US20130137635A1 (en) 2010-02-10 2013-05-30 Lexicon Pharmaceuticals, Inc. Tryptophan hydroxylase inhibitors for the treatment of metastatic bone disease
WO2011146583A2 (en) 2010-05-19 2011-11-24 Elan Pharma International Limited Nanoparticulate cinacalcet formulations
CA2807685C (en) 2010-08-13 2020-10-06 Aileron Therapeutics, Inc. P53 derived peptidomimetic macrocycle
US9096684B2 (en) 2011-10-18 2015-08-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP6450192B2 (en) 2012-02-15 2019-01-09 エイルロン セラピューティクス，インコーポレイテッド Triazole-bridged and thioether-bridged peptidomimetic macrocycles
WO2013123266A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US20130303763A1 (en) 2012-03-30 2013-11-14 Michael D. Gershon Methods and compositions for the treatment of necrotizing enterocolitis
US9604919B2 (en) 2012-11-01 2017-03-28 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
JP2017521479A (en) 2014-05-15 2017-08-03 ラニ セラピューティクス， エルエルシー Solid mass pharmaceutical composition comprising a polypeptide and / or protein and method for producing the same
AU2015320549A1 (en) 2014-09-24 2017-04-13 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
BR112017019738A2 (en) 2015-03-20 2018-05-29 Aileron Therapeutics Inc peptidomimetic macrocycles and their uses
CN105381843B (en) * 2015-11-25 2017-08-15 河北新四达电机股份有限公司 Low speed large torque moment permanent-magnet motor-direct-drive type Ball Mill System
JP2019507181A (en) 2016-03-04 2019-03-14 チャールストン ラボラトリーズ，インコーポレイテッド Pharmaceutical composition
US10881135B1 (en) 2017-11-10 2021-01-05 Creative Destruction, LLC Cyclonically cooled and filtered smoking water pipe and method
CN109012906A (en) * 2018-07-10 2018-12-18 黄玉发 A kind of building waste compaction type crushing device

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2350534A (en) * 1942-10-05 1944-06-06 Rosinger Arthur Magnetic stirrer
GB947530A (en) * 1961-09-26 1964-01-22 Gen Electric Co Ltd Improvements in or relating to grinding mills, pelletising mills and like apparatus
US4401672A (en) * 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
DE3345680A1 (en) 1983-12-16 1985-06-20 Gebrüder Netzsch, Maschinenfabrik GmbH & Co, 8672 Selb AGITATOR MILL
US4645131A (en) * 1984-12-24 1987-02-24 Hailey Robert W Powder milling method to produce fine powder sizes
DE3765316D1 (en) * 1986-06-20 1990-11-08 Inoue Mfg DISPERSING AND GRINDING APPARATUS.
FR2608988B1 (en) 1986-12-31 1991-01-11 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF COLLOIDAL DISPERSIBLE SYSTEMS OF A SUBSTANCE, IN THE FORM OF NANOPARTICLES
JPH0658069B2 (en) * 1987-04-03 1994-08-03 三菱電機株式会社 Engine accessory drive
JPH01171627A (en) * 1987-12-28 1989-07-06 Inoue Seisakusho:Kk Mixing and dispersing treatment device
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
NZ248813A (en) 1992-11-25 1995-06-27 Eastman Kodak Co Polymeric grinding media used in grinding pharmaceutical substances
TW384224B (en) 1994-05-25 2000-03-11 Nano Sys Llc Method of preparing submicron particles of a therapeutic or diagnostic agent
DE19533369C2 (en) * 1995-09-09 1998-06-10 Hermann Getzmann Dispersing device and method
DE19613366A1 (en) * 1996-04-03 1997-10-09 Goldschmidt Ag Th Device for treating suspensions
US6245357B1 (en) * 1998-03-06 2001-06-12 Alza Corporation Extended release dosage form
US6336603B1 (en) * 1999-01-12 2002-01-08 Island Oasis Frozen Cocktail Company, Inc. Food processing apparatus including magnetic drive
DE60227802D1 (en) * 2001-06-05 2008-09-04 Elan Pharma Int Ltd GRINDING MACHINE AND METHOD FOR THE OPERATION

Also Published As

Publication number Publication date
AU2002312230A1 (en) 2002-12-16
EP1392441A1 (en) 2004-03-03
DE60227802D1 (en) 2008-09-04
US20040195413A1 (en) 2004-10-07
DK1392441T3 (en) 2010-01-25
CY1108429T1 (en) 2014-04-09
JP4223390B2 (en) 2009-02-12
JP2004535919A (en) 2004-12-02
US7575184B2 (en) 2009-08-18
EP1392441B1 (en) 2008-07-23
ES2309177T3 (en) 2008-12-16
US20080025807A1 (en) 2008-01-31
PT1392441E (en) 2008-09-30
US6742734B2 (en) 2004-06-01
US20020179758A1 (en) 2002-12-05
WO2002098565A1 (en) 2002-12-12
ATE401959T1 (en) 2008-08-15
CA2449490C (en) 2010-10-05

Similar Documents

Publication Publication Date Title
CA2449490A1 (en) System and method for milling materials
JP2004535919A5 (en)
EP0756917A4 (en) Separation type grinding surface plate and grinding apparatus using same
EP1037363A3 (en) Motor for rotating a disk-shaped information recording medium in a disk drive apparatus
EP1592007A3 (en) Data erasure apparatus, data erasure method and method for writing servo patterns on recording disk
JPH10180611A (en) Magnetic grinding method and device based on generation of plurality of alternating fields
EP0810719A4 (en) Multi-degree-of-freedom motor
HK1070132A1 (en) Laboratory apparatus for grinding loose materials
WO2004098828A3 (en) Motorized precision spindle apparatus
CN210054530U (en) Magnetic traction device and lotus seed clamping device applying same
JPS6315947A (en) Portable polishing apparatus for dental instrument
DE20307913U1 (en) Laboratory bench rotary vacuum concentrator comprises internal magnetic drive, for slow removal of solvent in test tube scale preparations
KR970072164A (en) Plasma processing chamber with planetary magnet source assembly
EP1946923A3 (en) Reciprocating cylinder of an inking or dampening system
EP0926275A3 (en) Open-end spinning device for making S or Z twist yarns
GB2412014A (en) Toothbrush driven by magnets
JPS5645752A (en) Stirrer
CN1531877A (en) Device for removing foreign matter from tobacco
JPS63221965A (en) Method and device for polishing pipe material
DE3368878D1 (en) Washing apparatus
CN217702921U (en) Semiconductor processing grinding device
CN214439824U (en) Grinding device for drug synthesis
CN212051324U (en) Microbial cultivation device
CN220372940U (en) Inner wall rust removing equipment for needle bearing machining
CN209973060U (en) Rotary bottling of anatomical specimen

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20220531