CA2454174A1 - Bioactive spinal implant material and method of manufacture thereof - Google Patents
Bioactive spinal implant material and method of manufacture thereof Download PDFInfo
- Publication number
- CA2454174A1 CA2454174A1 CA002454174A CA2454174A CA2454174A1 CA 2454174 A1 CA2454174 A1 CA 2454174A1 CA 002454174 A CA002454174 A CA 002454174A CA 2454174 A CA2454174 A CA 2454174A CA 2454174 A1 CA2454174 A1 CA 2454174A1
- Authority
- CA
- Canada
- Prior art keywords
- synthetic
- implant material
- weight
- bioactive
- filler
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/18—Materials at least partially X-ray or laser opaque
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30965—Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/36—Femoral heads ; Femoral endoprostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
- A61F2/447—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages substantially parallelepipedal, e.g. having a rectangular or trapezoidal cross-section
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2892—Tibia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/3008—Properties of materials and coating materials radio-opaque, e.g. radio-opaque markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30957—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using a positive or a negative model, e.g. moulds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/36—Femoral heads ; Femoral endoprostheses
- A61F2/3609—Femoral heads or necks; Connections of endoprosthetic heads or necks to endoprosthetic femoral shafts
- A61F2002/3625—Necks
- A61F2002/3631—Necks with an integral complete or partial peripheral collar or bearing shoulder at its base
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
- A61F2002/4649—Bone graft or bone dowel harvest sites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
- A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00017—Iron- or Fe-based alloys, e.g. stainless steel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00329—Glasses, e.g. bioglass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs
Abstract
Bioactive spinal implant materials having optimized radiopacity, stiffness, and bioactivity properties for formulation of shaped bodies capable of withstanding large dynamic, compressive loads are provided. The invention al so provides methods of making the optimized implant materials.
Claims (35)
1. A synthetic, bioactive spinal implant material having a range of radiopacity from about 30 to about 55 and a range of stiffness from about 6 GPa to about 20 GPa.
2. The synthetic, bioactive spinal implant material of claim 1 formed from a polymerized resin matrix.
3. The synthetic, bioactive spinal implant material of claim 1 wherein the material includes at least one filler.
4. The synthetic, bioactive spinal implant material of claim 3 wherein the at least one filler includes a bioactive filler.
5. The synthetic, bioactive spinal implant material of claim 4 wherein the bioactive filler is combeite.
6. The synthetic, bioactive spinal implant material of claim 2, wherein the polymerized resin matrix includes a DUDMA and a TEDGMA resin.
7. The synthetic, bioactive spinal implant material of claim 2 wherein the polymerized resin matrix comprises about 10% by weight to about 90% by weight of the total composition of the implant material.
8. The synthetic, bioactive spinal implant material of claim 2 wherein the polymerized resin matrix comprises about 20% by weight to about 50% by weight of the total composition of the implant material.
9. The synthetic, bioactive spinal implant material of claim 3 wherein there is about 50% by weight to about 80% by weight filler comprising the total composition of the implant material.
10. The synthetic, bioactive spinal implant material of claim 1 wherein the shaped body is an implant.
11. The synthetic, bioactive spinal implant material of claim 10 in the form of a shaped body.
12. The synthetic, bioactive spinal implant material of claim 1 having a range of radiopacity from about 38 to about 50 and a stiffness from about 8 GPa to about 17 GPa.
13. A synthetic, artificial shaped body in the form of a spinal implant, said shaped body having a radiopacity of about 30 to about 55 and a range of stiffness from about 6 GPa to about 20 GPa.
14. The synthetic, artificial shaped body of claim 13 comprised of a polymerized resin matrix.
15. The synthetic, artificial shaped body of claim 13 wherein the implant includes at least one filler.
16. The synthetic, artificial shaped body of claim 15 wherein the at least one filler includes a bioactive filler.
17. The synthetic, artificial body of claim 16 wherein the bioactive filler is combeite.
18. The synthetic, artificial shaped body of claim 14, wherein the polymerized resin matrix includes a DUDMA and a TEDGMA resin.
19. The synthetic, artificial shaped body of claim 14 wherein the polymerized resin matrix comprises about 10% by weight to about 90% by weight of the total composition of the implant.
20. The synthetic, artificial shaped body of claim 14 wherein the polymerized resin matrix comprises about 20% by weight to about 50% by weight of the total composition of the implant.
21. The synthetic, artificial shaped body of claim 15 wherein the at least one filler comprises about 50% by weight to about 80% by weight of the total composition of the implant.
22. The synthetic, artificial shaped body of claim 13 having a radiopacity between about 38 to about 50 and a range of stiffness from about 8 GPa to about 17 GPa.
23. A synthetic spinal implant material comprising a polymerizable resin matrix comprising at least DUDMA and TEDGMA resins and at least one filler, said material, when polymerized, exhibiting a radiopacity from about 30 to about 55 and a stiffness of about 6 GPa to about 20 GPa; said polymerized material forming calcium phosphate on its surface when contacted with bodily fluid.
24. The synthetic spinal implant material of claim 23 wherein the polymerizable resin matrix comprises about 10% by weight to about 90% by weight of the total composition of the implant material.
25. The synthetic spinal implant material of claim 23 wherein the polymerizable resin matrix comprises about 20% by weight to about 50% by weight of the total composition of the implant material.
26. The synthetic spinal implant material of claim 23 wherein the at least one filler comprises about 50% to about 80% of the total composition of the implant material.
27. The synthetic spinal implant material of claim 23 wherein the at least one filler comprises a bioactive filler.
28. The synthetic spinal implant material of claim 23 wherein the at least one bioactive filler is combeite.
29. A method of making a synthetic spinal implant material:
-providing a blend of DUDMA and TEDGMA;
-mixing said resin blend with at least one filler, the blend comprising from about 10% by weight to about 90% by weight of the material; and -agitating the resultant mixture to form said implant material having, when polymerized, a radiopacity from about 30 to about 55 and a stiffness of about GPa to about 20 GPa.
-providing a blend of DUDMA and TEDGMA;
-mixing said resin blend with at least one filler, the blend comprising from about 10% by weight to about 90% by weight of the material; and -agitating the resultant mixture to form said implant material having, when polymerized, a radiopacity from about 30 to about 55 and a stiffness of about GPa to about 20 GPa.
30. The method of claim 26 wherein the at least one filler comprises a bioactive filler.
31. The method of claim 27 wherein the at least one bioactive filler is combeite.
32. The method of claim 26 wherein the polymerizable resin matrix comprises about 20% by weight to about 50% by weight of the total composition of the implant material.
33. The method of claim 26 wherein the filler comprises about 50% by weight to about 80% by weight of the total composition of the implant material.
34. The method of claim 26 wherein the material has a range of radiopacity from about 30 to about 55 and a range of stiffness from about 6 GPa to about 20 GPa.
35. The method of claim 26 wherein the material has a range of radiopacity of about 38 to about 50 and a range of stiffness from about 8 GPa to about 17 GPa.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30507001P | 2001-07-13 | 2001-07-13 | |
US60/305,070 | 2001-07-13 | ||
US33987101P | 2001-12-12 | 2001-12-12 | |
US60/339,871 | 2001-12-12 | ||
US10/127,947 US6987136B2 (en) | 2001-07-13 | 2002-04-23 | Bioactive spinal implant material and method of manufacture thereof |
US10/127,947 | 2002-04-23 | ||
PCT/US2002/020887 WO2003005937A1 (en) | 2001-07-13 | 2002-07-01 | Bioactive spinal implant material and method of manufacture thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2454174A1 true CA2454174A1 (en) | 2003-01-23 |
CA2454174C CA2454174C (en) | 2012-03-20 |
Family
ID=27383641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2454174A Expired - Fee Related CA2454174C (en) | 2001-07-13 | 2002-07-01 | Bioactive spinal implant material and method of manufacture thereof |
Country Status (5)
Country | Link |
---|---|
US (1) | US6987136B2 (en) |
EP (1) | EP1408883A1 (en) |
CA (1) | CA2454174C (en) |
MX (1) | MXPA04000359A (en) |
WO (1) | WO2003005937A1 (en) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2767675B1 (en) * | 1997-08-26 | 1999-12-03 | Materiel Orthopedique En Abreg | INTERSOMATIC IMPLANT AND ANCILLARY OF PREPARATION SUITABLE FOR ALLOWING ITS POSITION |
US6458162B1 (en) | 1999-08-13 | 2002-10-01 | Vita Special Purpose Corporation | Composite shaped bodies and methods for their production and use |
US7169183B2 (en) * | 2000-03-14 | 2007-01-30 | Warsaw Orthopedic, Inc. | Vertebral implant for promoting arthrodesis of the spine |
US6875212B2 (en) | 2000-06-23 | 2005-04-05 | Vertelink Corporation | Curable media for implantable medical device |
US6964667B2 (en) * | 2000-06-23 | 2005-11-15 | Sdgi Holdings, Inc. | Formed in place fixation system with thermal acceleration |
US6899713B2 (en) | 2000-06-23 | 2005-05-31 | Vertelink Corporation | Formable orthopedic fixation system |
WO2002000126A1 (en) * | 2000-06-23 | 2002-01-03 | University Of Southern California | Percutaneous vertebral fusion system |
US7238203B2 (en) * | 2001-12-12 | 2007-07-03 | Vita Special Purpose Corporation | Bioactive spinal implants and method of manufacture thereof |
US6793678B2 (en) | 2002-06-27 | 2004-09-21 | Depuy Acromed, Inc. | Prosthetic intervertebral motion disc having dampening |
GB0223327D0 (en) * | 2002-10-08 | 2002-11-13 | Ranier Ltd | Artificial spinal disc |
US7063725B2 (en) | 2002-10-21 | 2006-06-20 | Sdgi Holdings, Inc. | Systems and techniques for restoring and maintaining intervertebral anatomy |
US7125425B2 (en) * | 2002-10-21 | 2006-10-24 | Sdgi Holdings, Inc. | Systems and techniques for restoring and maintaining intervertebral anatomy |
AU2004212942A1 (en) | 2003-02-14 | 2004-09-02 | Depuy Spine, Inc. | In-situ formed intervertebral fusion device |
US20040267367A1 (en) | 2003-06-30 | 2004-12-30 | Depuy Acromed, Inc | Intervertebral implant with conformable endplate |
EP1682161A4 (en) * | 2003-10-29 | 2011-12-07 | Gentis Inc | Polymerizable emulsions for tissue engineering |
DE102004022505A1 (en) * | 2003-12-12 | 2005-08-18 | Centrum für Prototypenbau GmbH | Industrially-produced (especially cage) implant is predominantly made from a bone substitute material, especially PMMA, and can be patient-specific |
US9220595B2 (en) | 2004-06-23 | 2015-12-29 | Orthovita, Inc. | Shapeable bone graft substitute and instruments for delivery thereof |
GB0418421D0 (en) * | 2004-08-18 | 2004-09-22 | Pearsalls Ltd | Improvements in and relating to testing |
US20070111165A1 (en) * | 2005-05-26 | 2007-05-17 | Michael Wallick | Polymer Core Prosthetic Dental Device with an Esthetic Surface |
US8814567B2 (en) | 2005-05-26 | 2014-08-26 | Zimmer Dental, Inc. | Dental implant prosthetic device with improved osseointegration and esthetic features |
JP4975741B2 (en) * | 2005-05-26 | 2012-07-11 | ジマー デンタル, インコーポレイテッド | Artificial dental prosthesis |
US7947759B2 (en) * | 2005-08-08 | 2011-05-24 | Angstrom Medica | Cement products and methods of making and using the same |
EP1928346B1 (en) | 2005-08-30 | 2016-05-04 | Zimmer Dental, Inc. | Dental implant with improved osseointegration features |
US8562346B2 (en) | 2005-08-30 | 2013-10-22 | Zimmer Dental, Inc. | Dental implant for a jaw with reduced bone volume and improved osseointegration features |
US20070077267A1 (en) * | 2005-10-03 | 2007-04-05 | Sdgi Holdings, Inc. | Bioactive composite implants |
US20070276492A1 (en) * | 2006-05-09 | 2007-11-29 | Ranier Limited | Artificial spinal disc implant |
WO2008002682A2 (en) | 2006-06-29 | 2008-01-03 | Orthovita, Inc. | Bioactive bone graft substitute |
US8034110B2 (en) | 2006-07-31 | 2011-10-11 | Depuy Spine, Inc. | Spinal fusion implant |
US8968797B2 (en) * | 2006-09-25 | 2015-03-03 | Orthovita, Inc. | Bioactive load-bearing composites |
US8105382B2 (en) | 2006-12-07 | 2012-01-31 | Interventional Spine, Inc. | Intervertebral implant |
US20080138781A1 (en) * | 2006-12-08 | 2008-06-12 | Warsaw Orthopedic, Inc. | Surgical training model and method for use in facilitating training of a surgical procedure |
US8480718B2 (en) * | 2006-12-21 | 2013-07-09 | Warsaw Orthopedic, Inc. | Curable orthopedic implant devices configured to be hardened after placement in vivo |
US8663328B2 (en) * | 2006-12-21 | 2014-03-04 | Warsaw Orthopedic, Inc. | Methods for positioning a load-bearing component of an orthopedic implant device by inserting a malleable device that hardens in vivo |
US7771476B2 (en) * | 2006-12-21 | 2010-08-10 | Warsaw Orthopedic Inc. | Curable orthopedic implant devices configured to harden after placement in vivo by application of a cure-initiating energy before insertion |
US8758407B2 (en) * | 2006-12-21 | 2014-06-24 | Warsaw Orthopedic, Inc. | Methods for positioning a load-bearing orthopedic implant device in vivo |
US20080206297A1 (en) * | 2007-02-28 | 2008-08-28 | Roeder Ryan K | Porous composite biomaterials and related methods |
US8900307B2 (en) | 2007-06-26 | 2014-12-02 | DePuy Synthes Products, LLC | Highly lordosed fusion cage |
US8815973B2 (en) * | 2007-08-28 | 2014-08-26 | Pioneer Surgical Technology, Inc. | Cement products and methods of making and using the same |
US20090061389A1 (en) | 2007-08-30 | 2009-03-05 | Matthew Lomicka | Dental implant prosthetic device with improved osseointegration and shape for resisting rotation |
US20090138092A1 (en) * | 2007-11-28 | 2009-05-28 | Johnston Brent W | Therapeutic Structures for Utilization in Temporomandibular Joint Replacement Systems |
CA2710142A1 (en) | 2008-01-17 | 2009-07-23 | Beat Lechmann | An expandable intervertebral implant and associated method of manufacturing the same |
EP2273952B1 (en) | 2008-04-02 | 2018-02-21 | Pioneer Surgical Technology, Inc. | Intervertebral implant devices for supporting vertebrae and devices for insertion thereof |
WO2009124269A1 (en) | 2008-04-05 | 2009-10-08 | Synthes Usa, Llc | Expandable intervertebral implant |
US20090270988A1 (en) * | 2008-04-24 | 2009-10-29 | Ranier Limited | Artificial spinal disc implant |
US8899982B2 (en) | 2008-07-02 | 2014-12-02 | Zimmer Dental, Inc. | Implant with structure for securing a porous portion |
US8562348B2 (en) * | 2008-07-02 | 2013-10-22 | Zimmer Dental, Inc. | Modular implant with secured porous portion |
US9095396B2 (en) | 2008-07-02 | 2015-08-04 | Zimmer Dental, Inc. | Porous implant with non-porous threads |
US8231387B2 (en) | 2008-07-02 | 2012-07-31 | Zimmer, Inc. | Porous implant with non-porous threads |
US20100114314A1 (en) | 2008-11-06 | 2010-05-06 | Matthew Lomicka | Expandable bone implant |
US20100168798A1 (en) | 2008-12-30 | 2010-07-01 | Clineff Theodore D | Bioactive composites of polymer and glass and method for making same |
US8647614B2 (en) * | 2009-02-18 | 2014-02-11 | Orthovita, Inc. | Method for stabilizing vertebral body architecture |
US9526620B2 (en) | 2009-03-30 | 2016-12-27 | DePuy Synthes Products, Inc. | Zero profile spinal fusion cage |
US9707058B2 (en) | 2009-07-10 | 2017-07-18 | Zimmer Dental, Inc. | Patient-specific implants with improved osseointegration |
US9095444B2 (en) | 2009-07-24 | 2015-08-04 | Warsaw Orthopedic, Inc. | Implant with an interference fit fastener |
EP2493425B1 (en) * | 2009-10-29 | 2016-10-05 | Prosidyan, Inc. | Dynamic bioactive bone graft material and methods for handling |
US8602782B2 (en) | 2009-11-24 | 2013-12-10 | Zimmer Dental, Inc. | Porous implant device with improved core |
US9168138B2 (en) | 2009-12-09 | 2015-10-27 | DePuy Synthes Products, Inc. | Aspirating implants and method of bony regeneration |
US9393129B2 (en) | 2009-12-10 | 2016-07-19 | DePuy Synthes Products, Inc. | Bellows-like expandable interbody fusion cage |
US8778378B2 (en) | 2009-12-21 | 2014-07-15 | Orthovita, Inc. | Bioactive antibacterial bone graft materials |
US9265857B2 (en) | 2010-05-11 | 2016-02-23 | Howmedica Osteonics Corp. | Organophosphorous, multivalent metal compounds, and polymer adhesive interpenetrating network compositions and methods |
US8979860B2 (en) | 2010-06-24 | 2015-03-17 | DePuy Synthes Products. LLC | Enhanced cage insertion device |
US9592063B2 (en) | 2010-06-24 | 2017-03-14 | DePuy Synthes Products, Inc. | Universal trial for lateral cages |
WO2012003175A1 (en) | 2010-06-29 | 2012-01-05 | Synthes Usa, Llc | Distractible intervertebral implant |
US8480747B2 (en) | 2010-08-11 | 2013-07-09 | Warsaw Orthopedic, Inc. | Interbody spinal implants with extravertebral support plates |
US9402732B2 (en) | 2010-10-11 | 2016-08-02 | DePuy Synthes Products, Inc. | Expandable interspinous process spacer implant |
US8454694B2 (en) | 2011-03-03 | 2013-06-04 | Warsaw Orthopedic, Inc. | Interbody device and plate for spinal stabilization and instruments for positioning same |
US8765189B2 (en) | 2011-05-13 | 2014-07-01 | Howmedica Osteonic Corp. | Organophosphorous and multivalent metal compound compositions and methods |
US20130202670A1 (en) | 2012-02-03 | 2013-08-08 | Orthovita, Inc. | Bioactive antibacterial bone graft materials containing silver |
WO2014131020A2 (en) * | 2013-02-25 | 2014-08-28 | Ndsu Research Foundation | Artificial bone forms and compositions for approximating bone |
US9522070B2 (en) | 2013-03-07 | 2016-12-20 | Interventional Spine, Inc. | Intervertebral implant |
US11426290B2 (en) | 2015-03-06 | 2022-08-30 | DePuy Synthes Products, Inc. | Expandable intervertebral implant, system, kit and method |
CN109688981A (en) | 2016-06-28 | 2019-04-26 | Eit 新兴移植技术股份有限公司 | Distensible, adjustable angle intervertebral cage |
CN109688980B (en) | 2016-06-28 | 2022-06-10 | Eit 新兴移植技术股份有限公司 | Expandable and angularly adjustable intervertebral cage with articulation joint |
EP3320877B1 (en) * | 2016-11-14 | 2021-05-26 | Andreas Schwitalla | Implant made from fibre-reinforced plastic |
US10888433B2 (en) | 2016-12-14 | 2021-01-12 | DePuy Synthes Products, Inc. | Intervertebral implant inserter and related methods |
US10398563B2 (en) | 2017-05-08 | 2019-09-03 | Medos International Sarl | Expandable cage |
US11344424B2 (en) | 2017-06-14 | 2022-05-31 | Medos International Sarl | Expandable intervertebral implant and related methods |
US10940016B2 (en) | 2017-07-05 | 2021-03-09 | Medos International Sarl | Expandable intervertebral fusion cage |
US10092675B1 (en) * | 2017-08-12 | 2018-10-09 | Dewey M Sims, Jr. | Wear-resistant joint arthroplasty implant devices |
CA3074834A1 (en) | 2017-09-08 | 2019-03-14 | Pioneer Surgical Technology, Inc. | Intervertebral implants, instruments, and methods |
USD907771S1 (en) | 2017-10-09 | 2021-01-12 | Pioneer Surgical Technology, Inc. | Intervertebral implant |
US11446156B2 (en) | 2018-10-25 | 2022-09-20 | Medos International Sarl | Expandable intervertebral implant, inserter instrument, and related methods |
US11147903B2 (en) | 2019-03-23 | 2021-10-19 | Dewey M. Sims, Jr. | Wear-resistant joint arthroplasty implant devices |
US11426286B2 (en) | 2020-03-06 | 2022-08-30 | Eit Emerging Implant Technologies Gmbh | Expandable intervertebral implant |
US11850160B2 (en) | 2021-03-26 | 2023-12-26 | Medos International Sarl | Expandable lordotic intervertebral fusion cage |
US11752009B2 (en) | 2021-04-06 | 2023-09-12 | Medos International Sarl | Expandable intervertebral fusion cage |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4110184A (en) | 1973-04-24 | 1978-08-29 | Imperial Chemical Industries Limited | Photocurable dental filling compositions |
US4491453A (en) | 1980-08-29 | 1985-01-01 | Dentsply Research & Development Corp. | Process for restoring teeth with visible light curable compositions |
US4698373A (en) | 1981-01-21 | 1987-10-06 | Dentsply Research & Development Corp. | Stable one part dental compositions employing ipn technology |
US4801528A (en) | 1981-05-04 | 1989-01-31 | Dentsply Research & Development Corporation | Dental adhesive system |
US5024232A (en) | 1986-10-07 | 1991-06-18 | The Research Foundation Of State University Of Ny | Novel radiopaque heavy metal polymer complexes, compositions of matter and articles prepared therefrom |
US5415546A (en) | 1993-03-23 | 1995-05-16 | Cox, Sr.; Ronald W. | Radiopaque dental composite and materials |
US6039762A (en) | 1995-06-07 | 2000-03-21 | Sdgi Holdings, Inc. | Reinforced bone graft substitutes |
US5681742A (en) | 1995-09-26 | 1997-10-28 | Louisville Laboratories, Inc. | Biological specimen containment and incubation device |
US5681872A (en) | 1995-12-07 | 1997-10-28 | Orthovita, Inc. | Bioactive load bearing bone graft compositions |
US5914356A (en) | 1996-12-06 | 1999-06-22 | Orthovita, Inc. | Bioactive load bearing bone bonding compositions |
US5972368A (en) | 1997-06-11 | 1999-10-26 | Sdgi Holdings, Inc. | Bone graft composites and spacers |
US6123731A (en) | 1998-02-06 | 2000-09-26 | Osteotech, Inc. | Osteoimplant and method for its manufacture |
US6132465A (en) | 1998-06-04 | 2000-10-17 | Raymedica, Inc. | Tapered prosthetic spinal disc nucleus |
-
2002
- 2002-04-23 US US10/127,947 patent/US6987136B2/en not_active Expired - Fee Related
- 2002-07-01 EP EP02749739A patent/EP1408883A1/en not_active Withdrawn
- 2002-07-01 CA CA2454174A patent/CA2454174C/en not_active Expired - Fee Related
- 2002-07-01 MX MXPA04000359A patent/MXPA04000359A/en active IP Right Grant
- 2002-07-01 WO PCT/US2002/020887 patent/WO2003005937A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MXPA04000359A (en) | 2005-03-07 |
US20030087984A1 (en) | 2003-05-08 |
CA2454174C (en) | 2012-03-20 |
US6987136B2 (en) | 2006-01-17 |
WO2003005937A1 (en) | 2003-01-23 |
EP1408883A1 (en) | 2004-04-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2454174A1 (en) | Bioactive spinal implant material and method of manufacture thereof | |
US4878914A (en) | Ceramic prosthesis for living body & method of making the same | |
CA2128783A1 (en) | Injectable ceramic compositions and methods for their preparation and use | |
EP0519293A3 (en) | Implant material | |
IL113316A (en) | Slow-release matrix pellets and the production thereof | |
CA2427370A1 (en) | Bone cement mixture and x-ray contrast medium as well as method for their preparation | |
FR2870129A1 (en) | POLYMERIC CEMENT FOR PERCUTANEOUS VERTEBROPLASTY | |
AU4950099A (en) | Material for bone reconstruction | |
WO2006101751A3 (en) | A composite spinal nucleus implant with water absorption and swelling capabilities | |
CA2473861A1 (en) | Dental pastes, dental articles, and methods | |
BR9906822A (en) | Nanocomposite material based on a polymeric matrix and a double layer hydroxide, process for preparing the same, modified double layer hydroxide, and shaped article. | |
EP0353476A3 (en) | Biomedical material and method for making the same | |
WO2006056740A3 (en) | Bioabsorbable composite fibres | |
GR3024277T3 (en) | Tgf-beta formulation for inducing bone growth. | |
EP1329211A4 (en) | Antibacterial resin | |
EP0820737A3 (en) | Artificial dental implant | |
WO2008009361A3 (en) | Multicompartment granulate formulations for active substances | |
CA2396223A1 (en) | Instant granules and process for their formulation | |
MX9304263A (en) | PROCEDURE AND COMPOSITIONS FOR COMPACT DETERGENTS. | |
ATE142665T1 (en) | REINFORCED COMPOSITE RESIN | |
Canul‐Chuil et al. | Comparative study of bone cements prepared with either HA or α‐TCP and functionalized methacrylates | |
WO2010021517A3 (en) | Shoe insole | |
WO2002056929A3 (en) | Implant with porous calcium phosphate surface layer | |
CA2190764A1 (en) | Gel and cushioning devices | |
WO2000057932A3 (en) | Nanocomposite surgical materials and method of producing them |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20150702 |