CA2464485A1 - Microneedle transdermal transport device - Google Patents

Microneedle transdermal transport device Download PDF

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Publication number
CA2464485A1
CA2464485A1 CA002464485A CA2464485A CA2464485A1 CA 2464485 A1 CA2464485 A1 CA 2464485A1 CA 002464485 A CA002464485 A CA 002464485A CA 2464485 A CA2464485 A CA 2464485A CA 2464485 A1 CA2464485 A1 CA 2464485A1
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Canada
Prior art keywords
needle
formulation
transport device
transdermal transport
reservoir
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Granted
Application number
CA002464485A
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French (fr)
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CA2464485C (en
Inventor
Aimee B. Angel
Ian W. Hunter
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Massachusetts Institute of Technology
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Massachusetts Institute Of Technology
Aimee B. Angel
Ian W. Hunter
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Publication of CA2464485A1 publication Critical patent/CA2464485A1/en
Application granted granted Critical
Publication of CA2464485C publication Critical patent/CA2464485C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/155—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by gas introduced into the reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M2005/1401—Functional features
    • A61M2005/1405—Patient controlled analgesia [PCA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M2005/14204—Pressure infusion, e.g. using pumps with gas-producing electrochemical cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A61M2005/14252—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M2005/14268—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1581—Right-angle needle-type devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0266—Shape memory materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/65—Impedance, e.g. conductivity, capacity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means

Abstract

A transdermal transport device includes a reservoir for holding a formulation of an active principle, and a needle (14) with a bore extending along the length of the needle from a first end of the needle to a second end of the needle. The second end is substantially aligned to a plane parallel to a body surface of a biological body when the device is placed on the body surface.
The device also includes an actuator which pumps the formulation through the bore of the needle between a target area of the body and the reservoir.

Claims (71)

1. A transdermal transport device, comprising:
a reservoir for holding a formulation of an active principle;
more than one needle configured to attach the device to the body, each needle having a bore extending along the length of the needle from a first end of the needle to a second end of the needle, the second end being substantially aligned to a plane parallel to a body surface of a biological body when the device is placed on the body surface; and an actuator which pumps the formulation through the bore of each needle between a target area of the body and the reservoir.
2. The transdermal transport device of claim 1 wherein the second end moves in the plane to pierce the body surface.
3. The trandermal transport device of claim 1 wherein the actuator pumps the formulation into the biological body.
4. The transdermal transport device of claim 1 wherein the actuator is reversible to draw the formulation into the vial.
5. The transdermal transport device of claim 1 wherein each needle is positioned in a retracted state when the actuator is de-energized.
6. The transdermal transport device of claim 1 wherein the actuator includes a vapor generator.
7. The transdermal transport device of claim 1 wherein the actuator operates by an electrochemical process.
8. The transdermal transport device of claim 1 wherein the actuator is a conductive polymer.
9. The transdermal transport device of claim 1 further comprising an oscillator which causes the second end of each needle to vibrate along its length to reduce the force required to drive the needle into the body.
10. The transdermal transport device of claim 9 wherein the oscillator is a piezoelectric crystal which generates the vibration of the needle.
11. The transdermal transport device of claim 1 further comprising a sensor to monitor the status of a patient.
12. The transdermal transport device of claim 11 wherein the status is the glucose concentration of the patient.
13. The transdermal transport device of claim 12 wherein the formulation is insulin pumped into the patient, the amount of insulin pumped being based on the glucose concentration.
14. The transdermal transport device of claim 1 further comprising a base unit and a control unit, each needle being located within the base unit.
15. The transdermal transport device of claim 14 wherein the base unit and the control unit are separate connectable units.
16. The transdermal transport device of claim 1 wherein the second end is slanted.
17. The transdermal transport device of claim 16 wherein the slanted side is beveled.
18. The transdermal transport device of claim 1 further comprising a controller which provides operating instructions for the transport device.
19. The transdermal transport device of claim 1 wherein at least one of the needles has solid lip and openings positioned laterally about the bore.
20. The transdermal transport device of claim 1 wherein the actuator moves the first end into the reservoir with the bore being in fluid communication with the reservoir.
21. The transdermal transport device of claim 1 further comprising a rotary actuator which moves the second end of each needle in the plane.
22. The transdermal transport device of claim 1 wherein each needle is bent.
23. A transdermal transport device, comprising:
a reservoir for holding a formulation of an active principle; and a needle which transmits the formulation between the reservoir and a biological body, the needle having a bore extending along the length of the needle from a first end of the needle to a second end of the needle, the second end being substantially aligned in a plane parallel to a body surface of the biological body when the device is placed on the body surface, and the second end having tip end that is slanted and defines an opening from which the formulation is dispensed to control the direction of diffusion of the formulation into the body.
24. The transdermal transport device of claim 23 further comprising one or more additional needles.
25. The transdermal transport device of claim 23 wherein the needle has an outer diameter of about 30 µm to 250 µm.
26. The transdermal transport device of claim 23 wherein the needle has an inner diameter of about 10 µm to 100 µm
27. The transdermal transport device of claim 23 wherein the tip end is slanted between about 10° to 60°.
28. The transdermal transport device of claim 23 wherein the needle is made of 304 stainless steel.
29. A transdermal transport device, comprising:
a reservoir for holding a formulation of an active principle; and a needle having a hollow pathway through which the formulation is transported between an end portion of the needle and the reservoir, the end portion having a plurality of openings along its length, the formulation being dispensed from and drawn through the plurality of openings.
30. The transdermal transport device of claim 29 further comprising one or more additional needles.
31. The transdermal transport device of claim 29 wherein the needle has an outer diameter of about 30 µm to 250 µm.
32. The transdermal transport device of claim 29 wherein the needle has an inner diameter of about 10 µm to 100 µm
33. The transdermal transport device of claim 29 wherein the needle has from one to 20 openings.
34. The transdermal transport device of claim 33 wherein the openings are spaced apart between about 100 µm to 2 mm.
35. The transdermal transport device of claim 33 wherein the openings are located along a side of the needle facing away from the top of the skin when the needle has penetrated the skin.
36. The transdermal transport device of claim 35 where the needle is made of 304 stainless steel.
37. The transdermal transport device of claim 35 wherein the needle has a solid tip.
38. A transdermal transport device, comprising:
a reservoir for holding a formulation of an active principle;
a needle having a bore through which the formulation is transmitted between the reservoir and a body;
an actuator which pumps the formulation between the reservoir and the body; and a controller which directs the actuator to pump a desired amount of the formulation, the desired amount being dependent on input specifics of the body.
39. The transdermal transport device of claim 38 wherein the desired amount of the formulation is dispensed from the reservoir over a particular time period.
40. The transdermal transport device of claim 39 wherein the time period is from 1 sec to 10 days.
41. The transdermal transport device of claim 39 wherein the desired amount of formulation is dispensed incrementally over time.
42. The transdermal transport device of claim 38 wherein the body is a human patient.
43. The transdermal transport device of claim 38 wherein the desired amount of the formulation is a sample collected from a patient drawn into the reservoir over a particular time period.
44. A method of transporting a formulation of an active principle, comprising:
placing a delivery device with a reservoir for holding the formulation of an active principle on a body surface of a biological body;
inserting a needle into the body, the needle having a terminal end substantially aligned to a plane parallel to the body surface when the device is placed on the body surface; and pumping the formulation through a bore of the needle between a target area of the body and the reservoir.
45. ~The method of claim 44 wherein the inserting includes moving the terminal end in the plane.
46. The method of claim 44 wherein the pumping includes pumping the formulation into the biological body.
47. The method of claim 44 wherein the pumping includes drawing the formulation into the reservoir.
48. The method of claim 44 further comprising generating a longitudinal vibration along the length of the terminal end to reduce the needle the force required to drive the needle into the body.
49. The method of claim 44 further comprising monitoring the status the body, the body being a patient.
50. The method of claim 49 wherein the status is the glucose concentration of the patient.
51. The method of claim 50 wherein the formulation is insulin pumped into the patient, the amount of insulin pumped being based on the glucose concentration.
52. The method of claim 44 further comprising providing operating instructions to the device with a controller.
53. The method of claim 44 further comprising moving the needle relative to the reservoir such that the proximal end of the reservoir is moved into the reservoir.
54. The method of claim 53 wherein the inserting includes inserting one or more additional needles, each needle having a terminal end substantially aligned to a plane parallel to the body surface when the device is placed on the body surface, and having a bore through which the formulation is transported.
55. A method of transporting a formulation of an active principle, comprising:
placing a delivery device with a reservoir for holding the formulation of an active principle on a body surface of a biological body;
inserting a needle into the body, the needle transmitting the formulation between the reservoir and the biological body, the needle having a terminal end substantially aligned to a plane parallel to the body surface when the device is placed on the body surface, the terminal end being provided with a tip end that is slanted and defines an opening from which the formulation is dispensed to control the direction of diffusion of the formulation into the body.
56. The method of claim 55 wherein the inserting includes inserting one or more additional needles.
57. The method of claim 55 wherein the tip end is slanted between about 10°to 60°.
58. A method of transporting a formulation of an active principle, comprising:
placing a delivery device with a reservoir for holding the formulation of an active principle on a body surface of a biological body;
inserting a needle into the body, the needle having a hollow pathway through which the formulation is transported between an end portion of the needle and the reservoir, the end portion having a plurality of openings along its length, the formulation being dispensed from and drawn through the plurality of openings.
59. The method of claim 58 wherein the inserting includes inserting one or more additional needles.
60. The method of claim 58 wherein the needle has from one to 20 openings.
61. The method of claim 58 wherein the openings are spaced apart between about 100 µm to 2 mm.
62. A method of transporting a formulation of an active principle, comprising:
placing a delivery device with a reservoir for holding the formulation of an active principle on a body surface of a biological body;
inserting a needle into the body;

pumping the formulation through a bore of the needle between a target area of the body and the reservoir; and controlling the pumping to pump a desired amount of the formulation, the desired amount being dependent on input specifics of the body.
63. The method of claim 62 wherein the pumping includes pumping the desired amount of the formulation from the reservoir over a particular time period.
64. The method of claim 63 wherein the time period is from about 1 sec to 10 days.
65. The method of claim 63 wherein the pumping includes pumping the desired amount of the formulation incrementally over time.
66. The method of claim 62 wherein the body is a human patient.
67. The method of claim 66 wherein the formulation is a sample collected from a patient drawn into the reservoir over a particular time period.
68. A transdermal transport device, comprising:
a means for holding a formulation of an active principle;
a means for transporting the formulation between the means for holding and a target area of the body, the means for transporting having a first end and a second end, the second end being substantially aligned to a plane parallel to a body surface of a biological body when the device is placed on the body surface; and a means for pumping the formulation between the target area of the body and the first end of the means for holding.

-35.1-
69. The transdermal transport device of claim 22 wherein each bent needle defines a bend angle less than 180°.
70. The transdermal transport device of claim 69 wherein the bend angle is approximately 90°.
71. The transdermal transport device, comprising a reservoir for holding a formulation of an active principle;
a bent needle having a bore extending along the length of the bent needle from a first end of the bent needle to a second end of the bent needle, the second end being substantially aligned to a plane parallel to a body surface of a biological body when the device is placed on the body surface; and an actuator which pumps the formulation through the bore of the bent needle between a target area of the body and the reservoir.
CA2464485A 2001-10-26 2002-10-21 Microneedle transdermal transport device Expired - Fee Related CA2464485C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US33842501P 2001-10-26 2001-10-26
US60/338,425 2001-10-26
US39948902P 2002-07-29 2002-07-29
US60/399,489 2002-07-29
PCT/US2002/033794 WO2003037404A1 (en) 2001-10-26 2002-10-21 Microneedle transdermal transport device

Publications (2)

Publication Number Publication Date
CA2464485A1 true CA2464485A1 (en) 2003-05-08
CA2464485C CA2464485C (en) 2010-05-11

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CA2464483A Expired - Fee Related CA2464483C (en) 2001-10-26 2002-10-18 Microneedle transport device
CA2464485A Expired - Fee Related CA2464485C (en) 2001-10-26 2002-10-21 Microneedle transdermal transport device
CA2464670A Expired - Fee Related CA2464670C (en) 2001-10-26 2002-10-22 Transdermal transport device with suction
CA2464673A Expired - Fee Related CA2464673C (en) 2001-10-26 2002-10-22 Impedance sensor
CA002464487A Abandoned CA2464487A1 (en) 2001-10-26 2002-10-22 Transdermal transport device with an electrolytic actuator

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CA2464483A Expired - Fee Related CA2464483C (en) 2001-10-26 2002-10-18 Microneedle transport device

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CA2464670A Expired - Fee Related CA2464670C (en) 2001-10-26 2002-10-22 Transdermal transport device with suction
CA2464673A Expired - Fee Related CA2464673C (en) 2001-10-26 2002-10-22 Impedance sensor
CA002464487A Abandoned CA2464487A1 (en) 2001-10-26 2002-10-22 Transdermal transport device with an electrolytic actuator

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AT (3) ATE420680T1 (en)
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