CA2474564A1 - Side-to-side faims apparatus having an analyzer region with non-uniform spacing and method therefore - Google Patents

Side-to-side faims apparatus having an analyzer region with non-uniform spacing and method therefore Download PDF

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Publication number
CA2474564A1
CA2474564A1 CA002474564A CA2474564A CA2474564A1 CA 2474564 A1 CA2474564 A1 CA 2474564A1 CA 002474564 A CA002474564 A CA 002474564A CA 2474564 A CA2474564 A CA 2474564A CA 2474564 A1 CA2474564 A1 CA 2474564A1
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CA
Canada
Prior art keywords
electrode
ion
analyzer region
asymmetric waveform
ion outlet
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Granted
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CA002474564A
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French (fr)
Other versions
CA2474564C (en
Inventor
David Barnett
Roger Guevremont
Randy Purves
Mark Weir
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Thermo Finnigan LLC
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Ionalytics Corporation
David Barnett
Roger Guevremont
Randy Purves
Mark Weir
Thermo Finnigan Llc
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Publication of CA2474564A1 publication Critical patent/CA2474564A1/en
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Publication of CA2474564C publication Critical patent/CA2474564C/en
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3504—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Abstract

Disclosed is a high field asymmetric waveform ion mobility spectrometer (FAIMS) having a side-to-side electrode geometry. The FAIMS includes an inner electrode (102) having a length and an outer surface that is curved in a direction transverse to the length. The FAIMS also includes an outer electrode (104) having a length, a channel extending therethrough along at least a portion of the length, and a curved inner surface, a portion of the length of the outer electrode overlapping a portion of the length of the inner electrode so as to provide an analyzer region therebetween. The outer electrode has an ion inlet (114) for introducing ions from a source of ions into the analyzer region and an ion outlet (112) for extracting ions from the analyzer region, the ion inlet and the ion outlet being disposed on opposing sides of the outer electrode. The FAIMS is characterized in that at least one of the inner and outer electrodes is shaped such that a width of the analyzer region in the vicinity of the ion outlet is other than a width of the analyzer region in at least one other region.

Claims (31)

1. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry, comprising:
an inner electrode having a length and an outer surface that is curved in a direction transverse to the length; and, an outer electrode having a length, a channel extending therethrough along at least a portion of the length, and a curved inner surface, a portion of the length of the outer electrode overlapping a portion of the length of the inner electrode so as to provide an analyzer region therebetween, the outer electrode including an ion inlet for introducing ions from a source of ions into the analyzer region and an ion outlet for extracting ions from the analyzer region, the ion inlet and the ion outlet disposed on opposing sides of the outer electrode, Characterized in that:
at least one of the inner and outer electrodes is shaped such that a width of the analyzer region in the vicinity of the ion outlet is other than a width of the analyzer region in at least one other region.
2. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to claim 1 wherein the width of the analyzer region in the vicinity of the ion outlet is shorter than a width of the analyzer region in at least one other region.
3. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to any one of claims 1 and 2, wherein the outer surface of the inner electrode is generally circular along a first portion of the outer surface in a cross-section taken in a plane normal to the length, and is distorted from circular along a second portion of the outer surface.
4. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to claim 3, comprising an electrical controller for applying an asymmetric waveform voltage to at least one of the inner electrode and outer electrode and for applying a direct current compensation voltage to at least one of the inner electrode and outer electrode.
5. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to any one of claims 3 and 4, comprising a mechanism for rotating the inner electrode relative to the outer electrode.
6. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to claim 5, wherein the mechanism is for rotating the inner electrode relative to the outer electrode so as to adjustably vary the width of the analyzer region in the vicinity of the ion outlet.
7. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to any one of claims 1, 2, and 3, comprising a gas flow barrier for barring a flow of a gas through a portion of the analyzer region intermediate the gas flow barrier and the ion outlet.
8. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to any one of claims 5 and 6, comprising a gas flow barrier for barring a flow of a gas through a portion of the analyzer region intermediate the gas flow barrier and the ion outlet.
9. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to claim 8, wherein the inner electrode is rotatable between a first operating position and a second operating position, the second portion of the outer surface disposed in a spaced-apart facing arrangement with the ion outlet when the inner electrode is in the first operating position, and the second portion of the outer surface disposed within the portion of the analyzer region when the inner electrode is in the second operating position.
10. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to any one of claims 8 and 9, comprising a gas inlet defined within the curved inner surface of the outer electrode, the gas inlet disposed intermediate the gas flow barrier and the ion inlet for providing a flow of a gas into the analyzer region and out of the ion outlet.
11. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to claim 3, wherein the inner electrode is fixedly mounted relative to the outer electrode, the second portion of the outer surface disposed in a spaced-apart facing arrangement with the ion outlet.
12. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to any one of claims 1 and 2, comprising a mechanism for relatively moving the inner and outer electrodes.
13. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to claim 12, wherein the mechanism is for relatively moving the inner electrode with a translational motion from a first position to a second position nearer the ion outlet.
14. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to any one of claims 1 and 2, wherein the inner surface of the outer electrode has a truncated curved shape with a truncated side, the truncated side having portions thereof spaced substantially closer to the inner electrode than the curved portion of the truncated curved surface.
15. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to claim 4, wherein the second portion of the outer surface is disposed in a spaced-apart facing arrangement with the ion outlet, the spaced-apart facing arrangement being other than adjustable.
16. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to any one of claims 7 and 8, wherein the inner and outer electrodes are supported one relative to the other in an electrically insulating material, and wherein the gas flow barrier comprises a protrusion of the electrically insulating material.
17. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to claim 16, wherein the protrusion forms an approximately gas-tight seal with the outer surface of the inner electrode.
18. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry, comprising:
an outer electrode having a length and an inner surface that is curved in a direction transverse to the length, the outer electrode including an ion inlet within a first portion of the inner surface and an ion outlet within a second portion of the inner surface that is opposite the first portion of the inner surface; and, an eccentric inner electrode rotatably mounted in a spaced-apart arrangement with the outer electrode and defining an analyzer region therebetween, the inner electrode rotatable between a first position for providing a first width of the analyzer region in the vicinity of the ion outlet and a second position for providing a second width of the analyzer region in the vicinity of the ion outlet, the second width shorter than the first width.
19. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to claim 18, comprising a gas flow barrier disposed intermediate the ion inlet and the ion outlet for barring a flow of a gas in one direction around the inner electrode.
20. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to claim 19, comprising a mechanism for selectively switching the inner electrode between the first and second positions.
21. A high field asymmetric waveform ion mobility spectrometer having a side-to-side electrode geometry according to claim 19, comprising a mechanism for selectively rotating the inner electrode to vary approximately continuously the width of the analyzer region in the vicinity of the ion outlet.
22. A method for separating ions, the method comprising the steps of:

providing a FAIMS analyzer region having a side-to-side geometry, the analyzer region disposed between an outer electrode and an inner electrode, the outer electrode having anion inlet and an ion outlet, a radial distance between the ion outlet and an outer surface of the inner electrode being other than a radial distance between an inner surface of the outer electrode and the outer surface of the inner electrode in a region away from the ion outlet;
introducing ions from a source of ions into the analyzer region via the ion inlet;
transmitting at least some of the ions through the analyzer region between the ion inlet and the ion outlet at a given combination of an applied asymmetric waveform and an applied compensation voltage; and, extracting the transmitted ions from the analyzer region through the ion outlet.
23. A method according to claim 22, wherein the radial distance between the ion outlet and the outer surface of the inner electrode is smaller than the radial distance between the inner surface of the outer electrode and the outer surface of the inner electrode in the region away from the ion outlet.
24. A method of separating ions, the method comprising the steps of:
providing a FAIMS analyzer region having a side-to-side geometry, the analyzer region disposed between an outer electrode and an inner electrode, the outer electrode having an ion inlet and an ion outlet;
varying a spacing between the ion outlet and the inner electrode;
introducing ions from a source of ions into the analyzer region via the ion inlet;
transmitting at least some of the ions through the analyzer region between the ion inlet and the ion outlet at a given combination of an applied asymmetric waveform and an applied compensation voltage; and, extracting the transmitted ions from the analyzer region through the ion outlet.
25. A method according to claim 24, wherein the spacing is varied so as to increase an efficiency in the step of extracting ions from the analyzer region.
26. A method according to any one of claims 24 and 25, wherein the spacing is varied such that a radial distance between the ion outlet and an outer surface of the inner electrode is smaller than a radial distance between an inner surface of the outer electrode and the outer surface of the inner electrode in a region away from the ion outlet.
27. A method according to any one of claims 25 and 26, wherein the step of varying a spacing between the ion outlet and the inner electrode comprises a step of rotating the inner electrode relative to the outer electrode.
28. A method according to any one of claims 25 and 26, comprising the step of directing ions around the inner electrode in one direction only.
29. A method according to any one of claims 25 and 26, wherein the step of varying a spacing between the ion outlet and the inner electrode comprises a step of relatively moving the inner electrode toward the outer electrode.
30. A high field asymmetric waveform ion mobility spectrometer comprising:
an inner electrode having a length and a curved outer surface; and, an outer electrode having a length, a channel extending therethrough along at least a portion of the length, and a curved inner surface, a portion of the length of the outer electrode overlapping a portion of the length of the inner electrode so as to provide an analyzer region therebetween, the outer electrode defining an ion inlet and an ion outlet, the ion outlet disposed in a spaced-apart facing arrangement with a portion of the curved outer surface of the inner electrode, the ion outlet recessed within the curved inner surface of the outer electrode, such that a spacing between the portion of the curved outer surface and the ion outlet is longer than a spacing between a different portion of the curved outer surface and the curved inner surface of the outer electrode in a region away from the ion outlet.
31. A high field asymmetric waveform ion mobility spectrometer according to claim 30, comprising an electrical controller for applying an asymmetric waveform voltage to at least one of the inner electrode and outer electrode and for applying a direct current compensation voltage to at least one of the inner electrode and outer electrode.
CA2474564A 2002-02-08 2003-02-07 Side-to-side faims apparatus having an analyzer region with non-uniform spacing and method therefore Expired - Fee Related CA2474564C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35471102P 2002-02-08 2002-02-08
US60/354,711 2002-02-08
PCT/CA2003/000175 WO2003067243A1 (en) 2002-02-08 2003-02-07 Side-to-side faims apparatus having an analyzer region with non-uniform spacing and method therefore

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CA2474564A1 true CA2474564A1 (en) 2003-08-14
CA2474564C CA2474564C (en) 2010-09-28

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CA002475608A Abandoned CA2475608A1 (en) 2002-02-08 2003-01-09 Faims with non-destructive detection of selectively transmitted ions
CA002474561A Abandoned CA2474561A1 (en) 2002-02-08 2003-02-07 Faims apparatus and method for detecting trace amounts of a vapour in a carrier gas
CA2474564A Expired - Fee Related CA2474564C (en) 2002-02-08 2003-02-07 Side-to-side faims apparatus having an analyzer region with non-uniform spacing and method therefore
CA002474566A Abandoned CA2474566A1 (en) 2002-02-08 2003-02-07 Method for distinguishing between protein variants
CA002474584A Abandoned CA2474584A1 (en) 2002-02-08 2003-02-07 Faims apparatus having plural ion inlets and method therefore
CA002475555A Abandoned CA2475555A1 (en) 2002-02-08 2003-02-07 Segmented side-to-side faims
CA2474684A Expired - Fee Related CA2474684C (en) 2002-02-08 2003-02-07 Faims apparatus and method using carrier gases that contain a trace amount of a dopant species
CA2474586A Expired - Fee Related CA2474586C (en) 2002-02-08 2003-02-07 Method and apparatus for desolvating ions for introduction into a faims analyzer region

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CA002475608A Abandoned CA2475608A1 (en) 2002-02-08 2003-01-09 Faims with non-destructive detection of selectively transmitted ions
CA002474561A Abandoned CA2474561A1 (en) 2002-02-08 2003-02-07 Faims apparatus and method for detecting trace amounts of a vapour in a carrier gas

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CA002474566A Abandoned CA2474566A1 (en) 2002-02-08 2003-02-07 Method for distinguishing between protein variants
CA002474584A Abandoned CA2474584A1 (en) 2002-02-08 2003-02-07 Faims apparatus having plural ion inlets and method therefore
CA002475555A Abandoned CA2475555A1 (en) 2002-02-08 2003-02-07 Segmented side-to-side faims
CA2474684A Expired - Fee Related CA2474684C (en) 2002-02-08 2003-02-07 Faims apparatus and method using carrier gases that contain a trace amount of a dopant species
CA2474586A Expired - Fee Related CA2474586C (en) 2002-02-08 2003-02-07 Method and apparatus for desolvating ions for introduction into a faims analyzer region

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US (7) US6917036B2 (en)
EP (5) EP1481415A1 (en)
AU (8) AU2003201232A1 (en)
CA (8) CA2475608A1 (en)
WO (8) WO2003067244A2 (en)

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