CA2495234A1 - Endoprosthesis deployment system for treating vascular bifurcations - Google Patents

Endoprosthesis deployment system for treating vascular bifurcations Download PDF

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Publication number
CA2495234A1
CA2495234A1 CA002495234A CA2495234A CA2495234A1 CA 2495234 A1 CA2495234 A1 CA 2495234A1 CA 002495234 A CA002495234 A CA 002495234A CA 2495234 A CA2495234 A CA 2495234A CA 2495234 A1 CA2495234 A1 CA 2495234A1
Authority
CA
Canada
Prior art keywords
stent
deployment system
proximal end
deploying
bifurcation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002495234A
Other languages
French (fr)
Other versions
CA2495234C (en
Inventor
Jacques Seguin
Robert John Elicker
Jean-Claude Laborde
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biosensors International Group Ltd
Original Assignee
Devax, Inc.
Jacques Seguin
Robert John Elicker
Jean-Claude Laborde
Biosensors International Group, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Devax, Inc., Jacques Seguin, Robert John Elicker, Jean-Claude Laborde, Biosensors International Group, Ltd. filed Critical Devax, Inc.
Publication of CA2495234A1 publication Critical patent/CA2495234A1/en
Application granted granted Critical
Publication of CA2495234C publication Critical patent/CA2495234C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/856—Single tubular stent with a side portal passage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/9517—Instruments specially adapted for placement or removal of stents or stent-grafts handle assemblies therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/954—Instruments specially adapted for placement or removal of stents or stent-grafts for placing stents or stent-grafts in a bifurcation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
    • A61F2/966—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
    • A61F2/966—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
    • A61F2/9661—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod the proximal portion of the stent or stent-graft is released first
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/958—Inflatable balloons for placing stents or stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2002/065—Y-shaped blood vessels
    • A61F2002/067—Y-shaped blood vessels modular
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • A61F2002/91541—Adjacent bands are arranged out of phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/958—Inflatable balloons for placing stents or stent-grafts
    • A61F2002/9583—Means for holding the stent on the balloon, e.g. using protrusions, adhesives or an outer sleeve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0058—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements soldered or brazed or welded

Abstract

A device and method for treating pathological narrowing of fluid-carrying conduits of the human body (such as blood vessels) in an area of a bifurcation is disclosed. In particular, a stent system (10) comprising a pair of dissimilar stents (12, 14), one of which is particularly suited for treating a widened portion of a blood vessel immediately proximal to a bifurcation (30).
A stent delivery system (100) including a handpiece (102) adapted to selectively deliver the stents (12, 14) is also disclosed.

Claims (36)

1. A deployment system, comprising:
an elongate, flexible body, having a proximal end and a distal end;
a first stent on the body, having a first configuration; and a second stent on the body, having a second, different configuration.
2. A deployment system as in Claim 1, comprising a releasable restraint, for retaining the stents on the flexible body.
3. A deployment system as in any of the preceding claims, further comprising at least one inflatable balloon, for expanding at least one stent.
4. A deployment system as in any of the preceding claims, further comprising a guidewire lumen extending axially through at least a portion of the flexible body.
5. A deployment system as in any of the preceding claims, wherein the guidewire lumen has a proximal access port and a distal access port, and the proximal access port is positioned along the flexible body, spaced distally apart from the proximal end.
6. A deployment system as in any of the preceding claims, wherein the guidewire lumen has a proximal access port and a distal access port, and the proximal access port is positioned at the proximal end of the flexible body.
7. A deployment system as in airy of the preceding claims, wherein the releasable restraint comprises an axially movable control element extending along the length of the flexible body.
8. A deployment system as in any of the preceding claims, wherein the releasable restraint comprises a tubular sheath.
9. A deployment system as in any of the preceding claims, wherein the releasable restraint comprises a pull wire.
10. A deployment system as in any of the preceding claims, wherein the releasable restraint comprises a dissolvable media.
11. A deployment system as in any of the preceding claims, wherein the first and second stems have different expanded geometries.
12. A deployment system as in any of the preceding claims, wherein the first stent has a substantially cylindrical unconstrained expanded configuration, having a proximal end, a distal end and a substantially constant radius throughout.
13. A deployment system as in any of the preceding claims, wherein the second stent has an unconstrained expanded configuration in which a proximal end has a smaller diameter than a distal end.
14. A deployment system as in any of the preceding claims, wherein the expanded diameter of the second stent tapers radially outwardly in the distal direction.
15. A deployment system as in any of the preceding claims, wherein the first and second stents are carried by the catheter such that release of the stents from the catheter causes the proximal end of the first stent and the distal end of the second stent, as implanted, to be separated by a distance of no more than about 4 mm.
16. A deployment system as in any of the preceding claims, wherein the distance separating the proximal end of the first stent and the distal end of the second stent is no more than about 2 mm.
17. A deployment system as in any of the preceding claims, wherein the distance separating the proximal end of the first stent and the distal end of the second stent is no more than about 1 mm.
18. A deployment system according to any of the preceding claims, comprising:
a handpiece on the proximal end; and a control on the handpiece, the control having a first position for indicating partial deployment of the first stent, and a second position indicating complete deployment of the first stent.
19. A deployment system as in any of the preceding claims, wherein the control further comprises a third position indicating partial deployment of the second stent.
20. A deployment system as in any of the preceding claims, wherein the control further comprises a fourth position indicating complete deployment of the second stent.
21. A method of deploying first and second stents in the vicinity of a vascular bifurcation of a main vessel into first and second branch vessels, the method comprising the steps of:
providing a delivery catheter having first and second stents thereon;
positioning the catheter such that the first and second stents are in the vicinity of the bifurcation; and deploying the first stent in a branch vessel and the second stent in the main vessel;

wherein the second stent expands to a first diameter at a proximal end and a second, greater diameter at a distal end.
22. A method as in Claim 21, wherein the deploying step includes inflating a balloon within at least one of the stents.
23. A method as in Claim 21 or 22, wherein the deploying step comprises permitting at least one stent to self expand.
24. A method as in any of Claims 21-23, wherein the distal end of the second stent is positioned in proximity to the proximal end of the first stent.
25. A method as in any of Claims 21-24, wherein the distal end of the second stent expands to a greater diameter than the proximal end of the first stent.
26. A method as in any of Claims 21-25, wherein the distal end of the second stent expands to a diameter that is at least about 110% of the diameter of the proximal end of the first stent.
27. A method as in any of Claims 21-26, wherein the distal end of the second stent expands to a diameter that is at least about 105% of the diameter of the proximal end of the first stent.
28. A method as in any of Claims 21-27, further comprising the steps of:
deploying a substantially cylindrical stent in a first branch vessel; and deploying a tapered stent in the main vessel;
wherein both of the substantially cylindrical stent and the tapered stent are deployed from the same catheter.
29. A method of treating a vascular bifurcation as in any of Claims 21-28, wherein at least one of the substantially cylindrical stent and the tapered stent is deployed from a delivery catheter by proximally retracting an outer sheath on the delivery catheter.
30. A method of treating a vascular bifurcation as in any of Claims 21-29, wherein the tapered stent has a relatively smaller diameter first end and a larger second end, and the cylindrical stent is positioned adjacent the second end.
31. A method as in any of Claims 21-30, further comprising the steps of:
positioning the catheter in the vicinity of the bifurcation;
partially deploying the first stent into the first branch vessel;
introducing contrast media to permit visualization of the location of the first stent; and completely deploying the first stent into the first branch.
32. A method of treating a bifurcation as in any of Claims 21-31, further comprising the step of partially deploying the second stent in the main vessel.
33. A method of treating a bifurcation as in any of Claims 21-32, further comprising the step of introducing contrast media to permit visualization of the partially deployed second stent in the main vessel.
34. A method of treating a bifurcation as in any of Claims 21-33, further comprising the step of completely deploying the second stent in the main vessel.
35. A method of treating a bifurcation as in any of Claims 21-34, wherein the completely deploying the first stent step comprises proximally retracting a tubular sheath.
36. A method of treating a bifurcation as in any of Claims 21-35, wherein the completely deploying the second stent step comprises proximally retracting the tubular sheath.
CA2495234A 2002-08-20 2003-08-19 Endoprosthesis deployment system for treating vascular bifurcations Expired - Fee Related CA2495234C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/225,484 2002-08-20
US10/225,484 US7238197B2 (en) 2000-05-30 2002-08-20 Endoprosthesis deployment system for treating vascular bifurcations
PCT/US2003/025988 WO2004017865A1 (en) 2002-08-20 2003-08-19 Endoprosthesis deployment system for treating vascular bifurcations

Publications (2)

Publication Number Publication Date
CA2495234A1 true CA2495234A1 (en) 2004-03-04
CA2495234C CA2495234C (en) 2011-10-04

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CA2495234A Expired - Fee Related CA2495234C (en) 2002-08-20 2003-08-19 Endoprosthesis deployment system for treating vascular bifurcations

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US (5) US7238197B2 (en)
EP (1) EP1539042A1 (en)
JP (2) JP2005536284A (en)
AU (2) AU2003259932C1 (en)
CA (1) CA2495234C (en)
WO (1) WO2004017865A1 (en)

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US20050096726A1 (en) 2005-05-05
US7125419B2 (en) 2006-10-24
WO2004017865A1 (en) 2004-03-04
US7238197B2 (en) 2007-07-03
AU2009202028A2 (en) 2009-07-02
AU2009202028A1 (en) 2009-06-11
AU2003259932C1 (en) 2009-09-03
US20030125791A1 (en) 2003-07-03
US8603157B2 (en) 2013-12-10
EP1539042A1 (en) 2005-06-15
AU2003259932B2 (en) 2009-03-05
US8236041B2 (en) 2012-08-07
AU2009202028B2 (en) 2011-03-24
CA2495234C (en) 2011-10-04
US20070100425A1 (en) 2007-05-03
AU2003259932A1 (en) 2004-03-11
US20080046064A1 (en) 2008-02-21
JP2005536284A (en) 2005-12-02
US7686845B2 (en) 2010-03-30
US20030114912A1 (en) 2003-06-19
JP2011041833A (en) 2011-03-03

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