CA2495327A1 - Controlled release device and method using electrothermal ablation - Google Patents
Controlled release device and method using electrothermal ablation Download PDFInfo
- Publication number
- CA2495327A1 CA2495327A1 CA002495327A CA2495327A CA2495327A1 CA 2495327 A1 CA2495327 A1 CA 2495327A1 CA 002495327 A CA002495327 A CA 002495327A CA 2495327 A CA2495327 A CA 2495327A CA 2495327 A1 CA2495327 A1 CA 2495327A1
- Authority
- CA
- Canada
- Prior art keywords
- reservoir
- controlled release
- contents
- release
- reservoir cap
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0082—Catheter tip comprising a tool
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
- A61B5/283—Invasive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
- A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
- A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
- A61M2005/1726—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure the body parameters being measured at, or proximate to, the infusion site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0244—Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
- A61M2205/123—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/3653—General characteristics of the apparatus related to heating or cooling by Joule effect, i.e. electric resistance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M25/0069—Tip not integral with tube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
Abstract
Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. In one embodiment, the controlled release system is incorporated into an implantable drug delivery device.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40419602P | 2002-08-16 | 2002-08-16 | |
US60/404,196 | 2002-08-16 | ||
US46386503P | 2003-04-18 | 2003-04-18 | |
US60/463,865 | 2003-04-18 | ||
PCT/US2003/025774 WO2004071487A2 (en) | 2002-08-16 | 2003-08-15 | Controlled release device and method |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2495327A1 true CA2495327A1 (en) | 2004-08-26 |
CA2495327C CA2495327C (en) | 2008-10-21 |
Family
ID=32871667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002495327A Expired - Fee Related CA2495327C (en) | 2002-08-16 | 2003-08-15 | Controlled release device and method using electrothermal ablation |
Country Status (10)
Country | Link |
---|---|
US (4) | US7510551B2 (en) |
EP (1) | EP1528940B1 (en) |
JP (2) | JP4436258B2 (en) |
KR (1) | KR100725973B1 (en) |
CN (1) | CN100594892C (en) |
AT (1) | ATE505224T1 (en) |
AU (1) | AU2003303288B2 (en) |
CA (1) | CA2495327C (en) |
DE (1) | DE60336727D1 (en) |
WO (1) | WO2004071487A2 (en) |
Families Citing this family (130)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7070590B1 (en) | 1996-07-02 | 2006-07-04 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
WO2001064344A2 (en) * | 2000-03-02 | 2001-09-07 | Microchips, Inc. | Microfabricated devices for the storage and selective exposure of chemicals and devices |
ATE441110T1 (en) * | 2000-11-09 | 2009-09-15 | Sicel Technologies Inc | IN-VIVO DETECTION OF BIOMOLECULE CONCENTRATIONS USING FLUORESCENCE MARKERS |
US9107605B2 (en) * | 2000-11-17 | 2015-08-18 | Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. | Device for in vivo delivery of bioactive agents and method of manufacture thereof |
JP4657577B2 (en) * | 2001-01-09 | 2011-03-23 | マイクロチップス・インコーポレーテッド | Flexible microchip device for ocular and other applications |
DE10234589A1 (en) * | 2002-07-30 | 2004-02-12 | Robert Bosch Gmbh | Layer system used in the production of micro-electromechanical structures comprises a passivating layer consisting of an inorganic partial layer and a polymeric partial layer formed on a silicon layer |
US7510551B2 (en) * | 2002-08-16 | 2009-03-31 | Microchips, Inc. | Controlled release device and method using electrothermal ablation |
WO2004022033A1 (en) * | 2002-09-04 | 2004-03-18 | Microchips, Inc. | Method and device for the controlled delivery of parathyroid hormone |
ATE458534T1 (en) * | 2002-10-04 | 2010-03-15 | Microchips Inc | MEDICAL DEVICE FOR CONTROLLED DRUG ADMINISTRATION AND CARDIAC MONITORING AND/OR HEART STIMULATION |
IL152629A (en) * | 2002-11-04 | 2010-12-30 | Innoventions Ltd | Implantable medical device for controlled release of a substance |
WO2005010240A2 (en) * | 2003-07-17 | 2005-02-03 | Microchips, Inc. | Low temperature methods for hermetically sealing reservoir devices |
US20050055014A1 (en) * | 2003-08-04 | 2005-03-10 | Coppeta Jonathan R. | Methods for accelerated release of material from a reservoir device |
US7169405B2 (en) * | 2003-08-06 | 2007-01-30 | Warsaw Orthopedic, Inc. | Methods and devices for the treatment of intervertebral discs |
US8095197B2 (en) * | 2003-11-03 | 2012-01-10 | Microchips, Inc. | Medical device for sensing glucose |
CA2569375A1 (en) * | 2004-06-01 | 2006-08-17 | Microchips, Inc. | Devices and methods for measuring and enhancing drug or analyte transport to/from medical implant |
US20070036835A1 (en) * | 2004-07-19 | 2007-02-15 | Microchips, Inc. | Hermetically Sealed Devices for Controlled Release or Exposure of Reservoir Contents |
WO2006015299A2 (en) * | 2004-07-30 | 2006-02-09 | Microchips, Inc. | Multi-reservoir device for transdermal drug delivery and sensing |
JP5107041B2 (en) * | 2004-09-01 | 2012-12-26 | マイクロチップス・インコーポレーテッド | Multi-cap reservoir device for controlled release or exposure of reservoir contents |
US7350479B2 (en) * | 2004-09-10 | 2008-04-01 | United States Of America As Represented By The Secretary Of The Army | System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp |
US7156049B2 (en) * | 2004-09-10 | 2007-01-02 | The United States Of America As Represented By The Secretary Of The Army | Release mechanism to interact with biota, in particular fauna that may outgrow available habitat |
GB2418144A (en) * | 2004-09-17 | 2006-03-22 | Psimedica Ltd | Medical device for delivery of beneficial substance |
US20060093646A1 (en) * | 2004-10-28 | 2006-05-04 | Cima Michael J | Orthopedic and dental implant devices providing controlled drug delivery |
CA2584851C (en) | 2004-11-04 | 2015-04-07 | Microchips, Inc. | Compression and cold weld sealing methods and devices |
US7413846B2 (en) | 2004-11-15 | 2008-08-19 | Microchips, Inc. | Fabrication methods and structures for micro-reservoir devices |
WO2006081279A2 (en) * | 2005-01-25 | 2006-08-03 | Microchips, Inc. | Control of drug release by transient modification of local microenvironments |
US9095722B2 (en) * | 2005-02-01 | 2015-08-04 | Second Sight Medical Products, Inc. | Micro-miniature implantable coated device |
US8314024B2 (en) * | 2008-12-19 | 2012-11-20 | Unity Semiconductor Corporation | Device fabrication |
US20070016163A1 (en) * | 2005-06-28 | 2007-01-18 | Microchips, Inc. | Medical and dental implant devices for controlled drug delivery |
CN101217995A (en) | 2005-07-05 | 2008-07-09 | 皇家飞利浦电子股份有限公司 | Device for the controlled release of a predefined quantity of a substance |
EP1904148A2 (en) | 2005-07-05 | 2008-04-02 | Koninklijke Philips Electronics N.V. | Device for the controlled release of a predefined quantity of a substance |
US20070228606A1 (en) * | 2005-07-07 | 2007-10-04 | Specialty Coating Systems, Inc. | Nanoscale structures and methods of preparation |
US7387813B2 (en) * | 2005-07-07 | 2008-06-17 | Specialty Coating Systems, Inc. | Methods of preparation of hollow microstructures and nanostructures |
US20080228044A1 (en) * | 2005-10-11 | 2008-09-18 | Koninklijke Philips Electronics, N.V. | Individually Activated Sensors for Implantable Sensors |
US20070106277A1 (en) * | 2005-11-09 | 2007-05-10 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Remote controller for substance delivery system |
US8998886B2 (en) * | 2005-12-13 | 2015-04-07 | The Invention Science Fund I, Llc | Remote control of osmotic pump device |
US8992511B2 (en) * | 2005-11-09 | 2015-03-31 | The Invention Science Fund I, Llc | Acoustically controlled substance delivery device |
US8273071B2 (en) | 2006-01-18 | 2012-09-25 | The Invention Science Fund I, Llc | Remote controller for substance delivery system |
US8936590B2 (en) | 2005-11-09 | 2015-01-20 | The Invention Science Fund I, Llc | Acoustically controlled reaction device |
US7817030B2 (en) * | 2005-11-09 | 2010-10-19 | Invention Science Fund 1, Llc | Remote controller for in situ reaction device |
US9067047B2 (en) * | 2005-11-09 | 2015-06-30 | The Invention Science Fund I, Llc | Injectable controlled release fluid delivery system |
US7942867B2 (en) * | 2005-11-09 | 2011-05-17 | The Invention Science Fund I, Llc | Remotely controlled substance delivery device |
US8083710B2 (en) | 2006-03-09 | 2011-12-27 | The Invention Science Fund I, Llc | Acoustically controlled substance delivery device |
US20070148390A1 (en) * | 2005-12-27 | 2007-06-28 | Specialty Coating Systems, Inc. | Fluorinated coatings |
US20070191816A1 (en) * | 2006-02-13 | 2007-08-16 | Boston Scientific Scimed, Inc. | Radio frequency induced drug elution |
US20080140057A1 (en) * | 2006-03-09 | 2008-06-12 | Searete Llc, A Limited Liability Corporation Of State Of The Delaware | Injectable controlled release fluid delivery system |
US8642060B2 (en) * | 2006-04-24 | 2014-02-04 | Warsaw Orthopedic, Inc. | Controlled release systems and methods for osteal growth |
US7879027B2 (en) * | 2006-04-24 | 2011-02-01 | Warsaw Orthopedic, Inc. | Controlled release devices for fusion of osteal structures |
US7771414B2 (en) * | 2006-04-24 | 2010-08-10 | Warsaw Orthopedic, Inc. | Controlled release devices for therapeutic treatments of spinal discs |
US8642059B2 (en) * | 2006-04-24 | 2014-02-04 | Warsaw Orthopedic, Inc. | Controlled release systems and methods for intervertebral discs |
EP2024999A1 (en) * | 2006-05-05 | 2009-02-18 | Koninklijke Philips Electronics N.V. | Device and method for the controlled release of a predefined quantity of a substance |
JP5241714B2 (en) | 2006-07-07 | 2013-07-17 | プロテウス デジタル ヘルス, インコーポレイテッド | Smart parenteral delivery system |
EP2043728A2 (en) * | 2006-07-11 | 2009-04-08 | Microchips, Inc. | Multi-reservoir pump device for dialysis, biosensing, or delivery of substances |
WO2008017042A1 (en) * | 2006-08-03 | 2008-02-07 | Microchips, Inc. | Cardiac biosensor devices and methods |
WO2008029372A2 (en) * | 2006-09-08 | 2008-03-13 | Koninklijke Philips Electronics N.V. | Device for the controlled release of a predefined quantity of a substance |
US8138588B2 (en) * | 2006-12-21 | 2012-03-20 | Texas Instruments Incorporated | Package stiffener and a packaged device using the same |
US7998110B2 (en) * | 2007-04-25 | 2011-08-16 | Hong Kong Polytechnic University | Medical device for delivering drug and/or performing physical therapy |
WO2008154416A2 (en) * | 2007-06-07 | 2008-12-18 | Microchips, Inc. | Electrochemical biosensors and arrays |
US8753304B2 (en) | 2007-08-17 | 2014-06-17 | The Invention Science Fund I, Llc | Systems, devices, and methods including catheters having acoustically actuatable waveguide components for delivering a sterilizing stimulus to a region proximate a surface of the catheter |
US9005263B2 (en) | 2007-08-17 | 2015-04-14 | The Invention Science Fund I, Llc | System, devices, and methods including actively-controllable sterilizing excitation delivery implants |
US8702640B2 (en) | 2007-08-17 | 2014-04-22 | The Invention Science Fund I, Llc | System, devices, and methods including catheters configured to monitor and inhibit biofilm formation |
US8734718B2 (en) | 2007-08-17 | 2014-05-27 | The Invention Science Fund I, Llc | Systems, devices, and methods including catheters having an actively controllable therapeutic agent delivery component |
US8706211B2 (en) | 2007-08-17 | 2014-04-22 | The Invention Science Fund I, Llc | Systems, devices, and methods including catheters having self-cleaning surfaces |
US8366652B2 (en) | 2007-08-17 | 2013-02-05 | The Invention Science Fund I, Llc | Systems, devices, and methods including infection-fighting and monitoring shunts |
EP2211974A4 (en) * | 2007-10-25 | 2013-02-27 | Proteus Digital Health Inc | Fluid transfer port information system |
US8419638B2 (en) * | 2007-11-19 | 2013-04-16 | Proteus Digital Health, Inc. | Body-associated fluid transport structure evaluation devices |
US7833266B2 (en) * | 2007-11-28 | 2010-11-16 | Boston Scientific Scimed, Inc. | Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment |
DE102008024447A1 (en) | 2008-05-20 | 2009-11-26 | Biotronik Crm Patent Ag | Implantable shock electrode lead and implantable defibrillation assembly |
JP5670326B2 (en) * | 2008-06-25 | 2015-02-18 | メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ | Electronic pill with multiple drug reservoirs |
US7951193B2 (en) * | 2008-07-23 | 2011-05-31 | Boston Scientific Scimed, Inc. | Drug-eluting stent |
WO2010014690A2 (en) * | 2008-07-31 | 2010-02-04 | Boston Scientific Scimed, Inc. | Medical devices for therapeutic agent delivery |
US20110208023A1 (en) * | 2008-12-04 | 2011-08-25 | Goodall Eleanor V | Systems, devices, and methods including implantable devices with anti-microbial properties |
US20110295088A1 (en) * | 2008-12-04 | 2011-12-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems, devices, and methods including implantable devices with anti-microbial properties |
US8285387B2 (en) | 2008-12-12 | 2012-10-09 | Microchips, Inc. | Wireless communication with a medical implant |
US8685093B2 (en) | 2009-01-23 | 2014-04-01 | Warsaw Orthopedic, Inc. | Methods and systems for diagnosing, treating, or tracking spinal disorders |
US8126736B2 (en) | 2009-01-23 | 2012-02-28 | Warsaw Orthopedic, Inc. | Methods and systems for diagnosing, treating, or tracking spinal disorders |
GR1007310B (en) | 2009-03-09 | 2011-06-10 | Αχιλλεας Τσουκαλης | Implantable biosensor with automatic calibration |
BRPI1006765A2 (en) * | 2009-04-07 | 2019-03-26 | Koninl Philips Electronics Nv | ingestible capsule for drug release |
TW201043224A (en) * | 2009-06-06 | 2010-12-16 | Univ Nat Taiwan | Drug delivery chip and fabricating method thereof |
US9283305B2 (en) | 2009-07-09 | 2016-03-15 | Medtronic Vascular, Inc. | Hollow tubular drug eluting medical devices |
AU2010283838A1 (en) * | 2009-08-08 | 2012-03-01 | Sanofi-Aventis Deutschland Gmbh | Implantable sensor device and medical delivery device connectable to such a sensor device |
US20110070358A1 (en) | 2009-09-20 | 2011-03-24 | Medtronic Vascular, Inc. | Method of forming hollow tubular drug eluting medical devices |
EP2496936B1 (en) * | 2009-10-16 | 2018-02-21 | Microchips Biotech, Inc. | Multi-channel potentiostat for biosensor arrays and method of operation |
US8696740B2 (en) | 2010-01-05 | 2014-04-15 | The Johns Hopkins University | Implantable pressure-actuated drug delivery systems and methods of manufacture and use |
US8332020B2 (en) | 2010-02-01 | 2012-12-11 | Proteus Digital Health, Inc. | Two-wrist data gathering system |
AU2011210648B2 (en) | 2010-02-01 | 2014-10-16 | Otsuka Pharmaceutical Co., Ltd. | Data gathering system |
US9389158B2 (en) | 2010-02-12 | 2016-07-12 | Dan Angelescu | Passive micro-vessel and sensor |
US10408040B2 (en) | 2010-02-12 | 2019-09-10 | Fluidion Sas | Passive micro-vessel and sensor |
US9869613B2 (en) | 2010-02-12 | 2018-01-16 | Fluidion Sas | Passive micro-vessel and sensor |
US8506907B2 (en) * | 2010-02-12 | 2013-08-13 | Dan Angelescu | Passive micro-vessel and sensor |
US9772261B2 (en) | 2010-02-12 | 2017-09-26 | Fluidion Sas | Passive micro-vessel and sensor |
WO2012019083A2 (en) | 2010-08-06 | 2012-02-09 | Microchips, Inc. | Biosensor membrane composition, biosensor, and methods for making same |
US20130211219A1 (en) * | 2010-08-24 | 2013-08-15 | Micro CHIPS ,Inc. | Implantable Biosensor Device and Methods of Use Thereof |
WO2012035429A2 (en) | 2010-09-13 | 2012-03-22 | The University Of British Columbia | Remotely controlled drug delivery systems |
WO2013029037A2 (en) * | 2011-08-25 | 2013-02-28 | Microchips, Inc. | Space-efficient containment devices and method of making same |
US10427153B2 (en) | 2011-08-25 | 2019-10-01 | Microchips Biotech, Inc. | Systems and methods for sealing a plurality of reservoirs of a microchip element with a sealing grid |
WO2013067371A1 (en) | 2011-11-03 | 2013-05-10 | Robert Bosch Gmbh | Lithium-ion battery with life extension additive |
WO2013123595A1 (en) | 2012-02-22 | 2013-08-29 | Duchesnay Inc. | Formulation of doxylamine and pyridoxine and/or metabolites or salts thereof |
TWI635855B (en) * | 2012-02-29 | 2018-09-21 | 壯生和壯生視覺關懷公司 | Punctal plug with energized containment array |
KR102142912B1 (en) * | 2012-12-21 | 2020-08-10 | 마이크로칩스 바이오테크, 아이엔씨. | Implantable medical device for minimally-invasive insertion |
WO2014122221A1 (en) | 2013-02-06 | 2014-08-14 | Dan Angelescu | Passive micro-vessel and sensor |
CN104968268A (en) | 2013-02-06 | 2015-10-07 | 加州理工学院 | Miniaturized implantable electrochemical sensor devices |
CA2899076C (en) | 2013-02-28 | 2017-09-12 | Microchips Biotech, Inc. | Implantable medical device for minimally-invasive insertion |
US9486340B2 (en) | 2013-03-14 | 2016-11-08 | Medtronic Vascular, Inc. | Method for manufacturing a stent and stent manufactured thereby |
EP3574943B1 (en) | 2013-05-31 | 2021-06-30 | Zealand Pharma A/S | A fluid delivery device having an insertable prefilled cartridge |
US10028941B2 (en) | 2013-07-22 | 2018-07-24 | Duchesnay Inc. | Composition for the management of nausea and vomiting |
WO2015021031A1 (en) | 2013-08-05 | 2015-02-12 | Cam Med Llc | Conformable patch pump |
EP3126813B1 (en) | 2014-04-03 | 2021-01-20 | Fluidion | System and method for acquiring at least one sample from a fluid |
EP3134041A1 (en) * | 2014-04-25 | 2017-03-01 | Johnson & Johnson Vision Care Inc. | Method and ophthalmic device with active agent release system |
EP3145561A1 (en) | 2014-05-20 | 2017-03-29 | Cequr SA | Medicine delivery device with restricted access filling port |
US10244951B2 (en) * | 2014-06-10 | 2019-04-02 | Acist Medical Systems, Inc. | Physiological sensor delivery device and method |
US9937124B2 (en) | 2014-09-11 | 2018-04-10 | International Business Machines Corporation | Microchip substance delivery devices having low-power electromechanical release mechanisms |
US9808608B2 (en) | 2014-11-16 | 2017-11-07 | International Business Machines Corporation | Helical coil delivery device for active agent |
US10368788B2 (en) * | 2015-07-23 | 2019-08-06 | California Institute Of Technology | System and methods for wireless drug delivery on command |
US10881788B2 (en) | 2015-10-30 | 2021-01-05 | International Business Machines Corporation | Delivery device including reactive material for programmable discrete delivery of a substance |
US10286198B2 (en) | 2016-04-08 | 2019-05-14 | International Business Machines Corporation | Microchip medical substance delivery devices |
US11172879B2 (en) | 2016-05-09 | 2021-11-16 | King Abdullah University Of Science And Technology | Wearable personalized medicinal platform |
US10620151B2 (en) | 2016-08-30 | 2020-04-14 | Analog Devices Global | Electrochemical sensor, and a method of forming an electrochemical sensor |
US11268927B2 (en) | 2016-08-30 | 2022-03-08 | Analog Devices International Unlimited Company | Electrochemical sensor, and a method of forming an electrochemical sensor |
US10784877B2 (en) | 2016-12-21 | 2020-09-22 | Johnson & Johnson Vision Care, Inc. | Extended period timer circuits for ophthalmic devices |
US10737090B2 (en) | 2017-07-11 | 2020-08-11 | Medtronic, Inc. | External defibrillation electrode conductive electrolyte dispersal pad |
US10508755B2 (en) | 2017-07-21 | 2019-12-17 | International Business Machines Corporation | Fluid delivery device with hydrophobic surface |
WO2019138108A1 (en) | 2018-01-15 | 2019-07-18 | Fluidion | Passive micro-vessel and sensor |
US11022579B2 (en) | 2018-02-05 | 2021-06-01 | Analog Devices International Unlimited Company | Retaining cap |
US20210330901A1 (en) * | 2018-09-23 | 2021-10-28 | Douglas G. Metcalf | Systems and Methods to Administer Pharmaceuticals |
CA3126135A1 (en) | 2019-01-09 | 2020-07-16 | Twenty Twenty Therapeutics Llc | Eye mounted device for therapeutic agent release |
EP3909056A1 (en) | 2019-01-09 | 2021-11-17 | Twenty Twenty Therapeutics LLC | Programmable therapeutic agent delivery from eye mounted device |
US11406299B2 (en) | 2019-02-22 | 2022-08-09 | International Business Machines Corporation | Biosensors with programmable sensing cavities |
CN114728152A (en) | 2019-11-01 | 2022-07-08 | 达瑞微芯片生物技术公司 | Two-stage microchip drug delivery device and method |
EP4275593A1 (en) * | 2022-05-09 | 2023-11-15 | Wellspect AB | Disposable medical device assembly with sensor |
CN117228133A (en) * | 2022-06-15 | 2023-12-15 | 珠海纳思达信息技术有限公司 | Package, package assembly and method for upgrading data storage part |
Family Cites Families (121)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3692027A (en) * | 1971-04-23 | 1972-09-19 | Everett H Ellinwood Jr | Implanted medication dispensing device and method |
DE2505186C3 (en) * | 1974-02-15 | 1979-07-12 | N.V. Philips' Gloeilampenfabrieken, Eindhoven (Niederlande) | Programmable read-only memory |
US4003379A (en) * | 1974-04-23 | 1977-01-18 | Ellinwood Jr Everett H | Apparatus and method for implanted self-powered medication dispensing |
US4146029A (en) * | 1974-04-23 | 1979-03-27 | Ellinwood Jr Everett H | Self-powered implanted programmable medication system and method |
US4089734A (en) * | 1974-09-16 | 1978-05-16 | Raytheon Company | Integrated circuit fusing technique |
US3952741A (en) * | 1975-01-09 | 1976-04-27 | Bend Research Inc. | Controlled release delivery system by an osmotic bursting mechanism |
US4209894A (en) * | 1978-04-27 | 1980-07-01 | Texas Instruments Incorporated | Fusible-link semiconductor memory |
US4345981A (en) * | 1978-11-24 | 1982-08-24 | Diamond Shamrock Corporation | Anodically polarized surface for biofouling and scale control |
US4360019A (en) * | 1979-02-28 | 1982-11-23 | Andros Incorporated | Implantable infusion device |
GB8422876D0 (en) * | 1984-09-11 | 1984-10-17 | Secr Defence | Silicon implant devices |
US4585652A (en) * | 1984-11-19 | 1986-04-29 | Regents Of The University Of Minnesota | Electrochemical controlled release drug delivery system |
US5252294A (en) * | 1988-06-01 | 1993-10-12 | Messerschmitt-Bolkow-Blohm Gmbh | Micromechanical structure |
US5200051A (en) * | 1988-11-14 | 1993-04-06 | I-Stat Corporation | Wholly microfabricated biosensors and process for the manufacture and use thereof |
US5041107A (en) * | 1989-10-06 | 1991-08-20 | Cardiac Pacemakers, Inc. | Electrically controllable, non-occluding, body implantable drug delivery system |
US5167625A (en) * | 1990-10-09 | 1992-12-01 | Sarcos Group | Multiple vesicle implantable drug delivery system |
US5493177A (en) * | 1990-12-03 | 1996-02-20 | The Regents Of The University Of California | Sealed micromachined vacuum and gas filled devices |
US5254081A (en) * | 1991-02-01 | 1993-10-19 | Empi, Inc. | Multiple site drug iontophoresis electronic device and method |
US5391164A (en) * | 1991-05-03 | 1995-02-21 | Giampapa; Vincent C. | Subcutaneous implantable multiple-agent delivery system |
US5605662A (en) * | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
WO1993009842A1 (en) * | 1991-11-13 | 1993-05-27 | Elan Corporation, Plc | Drug delivery device |
US5756117A (en) * | 1992-04-08 | 1998-05-26 | International Medical Asscociates, Inc. | Multidose transdermal drug delivery system |
US5304293A (en) * | 1992-05-11 | 1994-04-19 | Teknekron Sensor Development Corporation | Microsensors for gaseous and vaporous species |
US5380272A (en) * | 1993-01-28 | 1995-01-10 | Scientific Innovations Ltd. | Transcutaneous drug delivery applicator |
US5368588A (en) * | 1993-02-26 | 1994-11-29 | Bettinger; David S. | Parenteral fluid medication reservoir pump |
US5366454A (en) * | 1993-03-17 | 1994-11-22 | La Corporation De L'ecole Polytechnique | Implantable medication dispensing device |
US5368704A (en) * | 1993-08-06 | 1994-11-29 | Teknekron Corporation | Micro-electrochemical valves and method |
US6180239B1 (en) * | 1993-10-04 | 2001-01-30 | President And Fellows Of Harvard College | Microcontact printing on surfaces and derivative articles |
EP1157743B1 (en) | 1993-10-28 | 2009-03-11 | Houston Advanced Research Center | Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions |
US6129685A (en) * | 1994-02-09 | 2000-10-10 | The University Of Iowa Research Foundation | Stereotactic hypothalamic obesity probe |
US5660680A (en) * | 1994-03-07 | 1997-08-26 | The Regents Of The University Of California | Method for fabrication of high vertical aspect ratio thin film structures |
US5770076A (en) * | 1994-03-07 | 1998-06-23 | The Regents Of The University Of California | Micromachined capsules having porous membranes and bulk supports |
US5985328A (en) * | 1994-03-07 | 1999-11-16 | Regents Of The University Of California | Micromachined porous membranes with bulk support |
US5971931A (en) * | 1994-03-29 | 1999-10-26 | Raff; Gilbert Lewis | Biologic micromonitoring methods and systems |
US5585069A (en) * | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
US5504026A (en) * | 1995-04-14 | 1996-04-02 | Analog Devices, Inc. | Methods for planarization and encapsulation of micromechanical devices in semiconductor processes |
US7611533B2 (en) * | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
US5992769A (en) * | 1995-06-09 | 1999-11-30 | The Regents Of The University Of Michigan | Microchannel system for fluid delivery |
SE9502258D0 (en) * | 1995-06-21 | 1995-06-21 | Pharmacia Biotech Ab | Method for the manufacture of a membrane-containing microstructure |
WO1997007429A1 (en) * | 1995-08-18 | 1997-02-27 | President And Fellows Of Harvard College | Self-assembled monolayer directed patterning of surfaces |
US5662689A (en) * | 1995-09-08 | 1997-09-02 | Medtronic, Inc. | Method and apparatus for alleviating cardioversion shock pain |
US6051017A (en) * | 1996-02-20 | 2000-04-18 | Advanced Bionics Corporation | Implantable microstimulator and systems employing the same |
DE19610293C1 (en) * | 1996-03-15 | 1997-07-31 | Fraunhofer Ges Forschung | Electronically-breakable microencapsulation system for sensitive materials |
US5951881A (en) * | 1996-07-22 | 1999-09-14 | President And Fellows Of Harvard College | Fabrication of small-scale cylindrical articles |
US5824204A (en) * | 1996-06-27 | 1998-10-20 | Ic Sensors, Inc. | Micromachined capillary electrophoresis device |
US5797898A (en) * | 1996-07-02 | 1998-08-25 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
US7070590B1 (en) * | 1996-07-02 | 2006-07-04 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
US6136212A (en) * | 1996-08-12 | 2000-10-24 | The Regents Of The University Of Michigan | Polymer-based micromachining for microfluidic devices |
IN184589B (en) * | 1996-10-16 | 2000-09-09 | Alza Corp | |
US6326204B1 (en) * | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
DE19716683C1 (en) * | 1997-04-21 | 1998-06-04 | Fraunhofer Ges Forschung | Miniature encapsulation device for sensitive materials |
WO1998049548A1 (en) * | 1997-04-25 | 1998-11-05 | Caliper Technologies Corporation | Microfluidic devices incorporating improved channel geometries |
IL121286A0 (en) * | 1997-07-11 | 1998-01-04 | Pets N People Ltd | Apparatus and methods for dispensing pet care substances |
US5949187A (en) * | 1997-07-29 | 1999-09-07 | Motorola, Inc. | Organic electroluminescent device with plural microcavities |
US5961492A (en) * | 1997-08-27 | 1999-10-05 | Science Incorporated | Fluid delivery device with temperature controlled energy source |
US5842787A (en) * | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
US6081736A (en) * | 1997-10-20 | 2000-06-27 | Alfred E. Mann Foundation | Implantable enzyme-based monitoring systems adapted for long term use |
US6237398B1 (en) * | 1997-12-30 | 2001-05-29 | Remon Medical Technologies, Ltd. | System and method for monitoring pressure, flow and constriction parameters of plumbing and blood vessels |
US6140740A (en) * | 1997-12-30 | 2000-10-31 | Remon Medical Technologies, Ltd. | Piezoelectric transducer |
US6486588B2 (en) | 1997-12-30 | 2002-11-26 | Remon Medical Technologies Ltd | Acoustic biosensor for monitoring physiological conditions in a body implantation site |
US6475170B1 (en) | 1997-12-30 | 2002-11-05 | Remon Medical Technologies Ltd | Acoustic biosensor for monitoring physiological conditions in a body implantation site |
US6001090A (en) | 1998-02-09 | 1999-12-14 | Lenhart; Douglas | Thermal pharmaceutical delivery system |
US6027695A (en) * | 1998-04-01 | 2000-02-22 | Dupont Pharmaceuticals Company | Apparatus for holding small volumes of liquids |
US6757560B1 (en) * | 1999-04-09 | 2004-06-29 | Novosis Pharma Ag | Transdermal delivery system (TDS) with electrode network |
US6319241B1 (en) | 1998-04-30 | 2001-11-20 | Medtronic, Inc. | Techniques for positioning therapy delivery elements within a spinal cord or a brain |
US6161047A (en) | 1998-04-30 | 2000-12-12 | Medtronic Inc. | Apparatus and method for expanding a stimulation lead body in situ |
US6062461A (en) * | 1998-06-03 | 2000-05-16 | Delphi Technologies, Inc. | Process for bonding micromachined wafers using solder |
US6058752A (en) * | 1998-06-10 | 2000-05-09 | Feder; George N. | Pick-resistant lock system and method |
US6941171B2 (en) * | 1998-07-06 | 2005-09-06 | Advanced Bionics Corporation | Implantable stimulator methods for treatment of incontinence and pain |
US6908770B1 (en) * | 1998-07-16 | 2005-06-21 | Board Of Regents, The University Of Texas System | Fluid based analysis of multiple analytes by a sensor array |
US6201980B1 (en) * | 1998-10-05 | 2001-03-13 | The Regents Of The University Of California | Implantable medical sensor system |
US6232150B1 (en) * | 1998-12-03 | 2001-05-15 | The Regents Of The University Of Michigan | Process for making microstructures and microstructures made thereby |
US6289237B1 (en) * | 1998-12-22 | 2001-09-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Apparatus for energizing a remote station and related method |
US6171850B1 (en) * | 1999-03-08 | 2001-01-09 | Caliper Technologies Corp. | Integrated devices and systems for performing temperature controlled reactions and analyses |
US6178349B1 (en) * | 1999-04-15 | 2001-01-23 | Medtronic, Inc. | Drug delivery neural stimulation device for treatment of cardiovascular disorders |
US6669663B1 (en) * | 1999-04-30 | 2003-12-30 | Medtronic, Inc. | Closed loop medicament pump |
US6923784B2 (en) * | 1999-04-30 | 2005-08-02 | Medtronic, Inc. | Therapeutic treatment of disorders based on timing information |
US6683615B1 (en) * | 1999-06-09 | 2004-01-27 | 3Dlabs Inc., Ltd. | Doubly-virtualized texture memory |
US6587719B1 (en) * | 1999-07-01 | 2003-07-01 | Cyberonics, Inc. | Treatment of obesity by bilateral vagus nerve stimulation |
US6804558B2 (en) * | 1999-07-07 | 2004-10-12 | Medtronic, Inc. | System and method of communicating between an implantable medical device and a remote computer system or health care provider |
US6334859B1 (en) * | 1999-07-26 | 2002-01-01 | Zuli Holdings Ltd. | Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments |
WO2001012157A1 (en) * | 1999-08-18 | 2001-02-22 | Microchips, Inc. | Thermally-activated microchip chemical delivery devices |
US6491666B1 (en) * | 1999-11-17 | 2002-12-10 | Microchips, Inc. | Microfabricated devices for the delivery of molecules into a carrier fluid |
AU782639B2 (en) * | 1999-12-10 | 2005-08-18 | Massachusetts Institute Of Technology | Microchip devices for delivery of molecules and methods of fabrication thereof |
CN2414777Y (en) * | 1999-12-14 | 2001-01-17 | 陈刚 | Transcutaneous medicine osmosis instrument |
US6384353B1 (en) * | 2000-02-01 | 2002-05-07 | Motorola, Inc. | Micro-electromechanical system device |
WO2001064344A2 (en) | 2000-03-02 | 2001-09-07 | Microchips, Inc. | Microfabricated devices for the storage and selective exposure of chemicals and devices |
WO2001091902A2 (en) | 2000-05-30 | 2001-12-06 | Massachusetts Institute Of Technology | Methods and devices for sealing microchip reservoir devices |
CN2460122Y (en) * | 2000-06-19 | 2001-11-21 | 翁春晓 | Therapeutic head of microsonic conductometric skin-through dosage device |
US20020022826A1 (en) * | 2000-08-14 | 2002-02-21 | Reynolds John R. | Burst electrode |
US6403403B1 (en) * | 2000-09-12 | 2002-06-11 | The Aerospace Corporation | Diode isolated thin film fuel cell array addressing method |
US6437640B1 (en) * | 2000-09-12 | 2002-08-20 | The Aerospace Corporation | Addressable diode isolated thin film array |
EP1339312B1 (en) | 2000-10-10 | 2006-01-04 | Microchips, Inc. | Microchip reservoir devices using wireless transmission of power and data |
AU2002224453A1 (en) * | 2000-10-11 | 2002-04-22 | Microchips, Inc. | Microchip reservoir devices and facilitated corrosion of electrodes |
US8417334B2 (en) * | 2000-10-26 | 2013-04-09 | Medtronic, Inc. | Method and apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac conditions |
DE60139411D1 (en) * | 2000-10-26 | 2009-09-10 | Medtronic Inc | DEVICE FOR MINIMIZING THE EFFECTS OF A HEART INJURY |
US20030004549A1 (en) * | 2000-10-26 | 2003-01-02 | Medtronic, Inc. | Method and apparatus to minimize the effects of a cardiac insult |
US6378292B1 (en) * | 2000-11-10 | 2002-04-30 | Honeywell International Inc. | MEMS microthruster array |
DE10061057A1 (en) * | 2000-12-08 | 2002-06-13 | Pharmed Holding Gmbh | Chip systems for the controlled emission of chemically sensitive substances |
DE10063612C2 (en) | 2000-12-20 | 2002-11-07 | Fraunhofer Ges Forschung | Microsystem for controlling the delivery of active ingredients from an active ingredient reservoir as well as implant with microsystem |
JP4657577B2 (en) * | 2001-01-09 | 2011-03-23 | マイクロチップス・インコーポレーテッド | Flexible microchip device for ocular and other applications |
US6926670B2 (en) * | 2001-01-22 | 2005-08-09 | Integrated Sensing Systems, Inc. | Wireless MEMS capacitive sensor for physiologic parameter measurement |
DE10102817B4 (en) | 2001-01-23 | 2006-01-12 | Lts Lohmann Therapie-Systeme Ag | Device and method for heat pulse-assisted transdermal application of active substances |
US6571125B2 (en) * | 2001-02-12 | 2003-05-27 | Medtronic, Inc. | Drug delivery device |
US7181287B2 (en) | 2001-02-13 | 2007-02-20 | Second Sight Medical Products, Inc. | Implantable drug delivery device |
US6858220B2 (en) * | 2001-02-28 | 2005-02-22 | Second Sight Medical Products, Inc. | Implantable microfluidic delivery system using ultra-nanocrystalline diamond coating |
US20020144548A1 (en) * | 2001-04-06 | 2002-10-10 | Cohn Michael B. | High precision accelerometer |
WO2002089767A1 (en) * | 2001-05-03 | 2002-11-14 | Massachusetts Eye And Ear Infirmary | Implantable drug delivery device and use thereof |
US6733485B1 (en) * | 2001-05-25 | 2004-05-11 | Advanced Bionics Corporation | Microstimulator-based electrochemotherapy methods and systems |
CA2447643A1 (en) * | 2001-05-29 | 2002-12-05 | Medtronic, Inc. | Closed-loop neuromodulation for prevention and treatment of cardiac conditions |
US6973718B2 (en) | 2001-05-30 | 2005-12-13 | Microchips, Inc. | Methods for conformal coating and sealing microchip reservoir devices |
AU2002326304A1 (en) | 2001-05-31 | 2002-12-16 | Massachusetts Institute Of Technology | Microchip devices with improved reservoir opening |
EP1399135B1 (en) | 2001-06-28 | 2004-12-29 | Microchips, Inc. | Methods for hermetically sealing microchip reservoir devices |
ATE340852T1 (en) * | 2001-06-29 | 2006-10-15 | Univ Leland Stanford Junior | ARTIFICIAL CHIP INTERFACE CONNECTION FOR ELECTRONIC RIDING IMPLANT |
US6663615B1 (en) | 2001-09-04 | 2003-12-16 | The Ohio State University | Dual stage microvalve and method of use |
US7097775B2 (en) * | 2001-10-26 | 2006-08-29 | Second Sight Medical Products, Inc. | Coated microfluidic delivery system |
US7510551B2 (en) * | 2002-08-16 | 2009-03-31 | Microchips, Inc. | Controlled release device and method using electrothermal ablation |
WO2004022033A1 (en) * | 2002-09-04 | 2004-03-18 | Microchips, Inc. | Method and device for the controlled delivery of parathyroid hormone |
ATE458534T1 (en) * | 2002-10-04 | 2010-03-15 | Microchips Inc | MEDICAL DEVICE FOR CONTROLLED DRUG ADMINISTRATION AND CARDIAC MONITORING AND/OR HEART STIMULATION |
US7599737B2 (en) * | 2002-10-04 | 2009-10-06 | Microchips, Inc. | Medical device for neural stimulation and controlled drug delivery |
JP4734236B2 (en) * | 2003-04-25 | 2011-07-27 | ボストン サイエンティフィック サイムド,インコーポレイテッド | Device for the storage and controlled release of solid drugs and method of manufacturing the same |
EP3851030B1 (en) * | 2003-09-11 | 2024-01-17 | Labrador Diagnostics LLC | Medical device for analyte monitoring |
-
2003
- 2003-08-15 US US10/641,507 patent/US7510551B2/en active Active
- 2003-08-15 CA CA002495327A patent/CA2495327C/en not_active Expired - Fee Related
- 2003-08-15 WO PCT/US2003/025774 patent/WO2004071487A2/en active Application Filing
- 2003-08-15 DE DE60336727T patent/DE60336727D1/en not_active Expired - Lifetime
- 2003-08-15 AU AU2003303288A patent/AU2003303288B2/en not_active Ceased
- 2003-08-15 AT AT03815904T patent/ATE505224T1/en not_active IP Right Cessation
- 2003-08-15 EP EP03815904A patent/EP1528940B1/en not_active Expired - Lifetime
- 2003-08-15 CN CN03822267A patent/CN100594892C/en not_active Expired - Fee Related
- 2003-08-15 JP JP2004568295A patent/JP4436258B2/en not_active Expired - Fee Related
- 2003-08-15 KR KR1020057002664A patent/KR100725973B1/en active IP Right Grant
-
2005
- 2005-10-26 US US11/259,301 patent/US7455667B2/en not_active Expired - Lifetime
- 2005-10-27 US US11/260,526 patent/US7910151B2/en active Active
-
2008
- 2008-10-01 US US12/243,791 patent/US8211092B2/en active Active
-
2009
- 2009-04-21 JP JP2009103479A patent/JP5313756B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR100725973B1 (en) | 2007-06-11 |
WO2004071487A2 (en) | 2004-08-26 |
KR20050035277A (en) | 2005-04-15 |
US8211092B2 (en) | 2012-07-03 |
JP5313756B2 (en) | 2013-10-09 |
ATE505224T1 (en) | 2011-04-15 |
AU2003303288A1 (en) | 2004-09-06 |
US20040121486A1 (en) | 2004-06-24 |
CN1681542A (en) | 2005-10-12 |
US20060100608A1 (en) | 2006-05-11 |
WO2004071487A3 (en) | 2004-09-30 |
US20090030404A1 (en) | 2009-01-29 |
JP2006515860A (en) | 2006-06-08 |
AU2003303288B2 (en) | 2006-12-07 |
EP1528940A2 (en) | 2005-05-11 |
US7910151B2 (en) | 2011-03-22 |
JP2009195721A (en) | 2009-09-03 |
US20080168921A1 (en) | 2008-07-17 |
EP1528940B1 (en) | 2011-04-13 |
US7455667B2 (en) | 2008-11-25 |
CA2495327C (en) | 2008-10-21 |
JP4436258B2 (en) | 2010-03-24 |
CN100594892C (en) | 2010-03-24 |
US7510551B2 (en) | 2009-03-31 |
DE60336727D1 (en) | 2011-05-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2495327A1 (en) | Controlled release device and method using electrothermal ablation | |
TW374006B (en) | Electric fumigation device | |
WO2002099457A3 (en) | Microchip devices with improved reservoir opening | |
WO2003043678A3 (en) | Syringe bandolier with control feature | |
AU2002254712A1 (en) | Bipolar or ultrasonic surgical device | |
WO2003026557A3 (en) | Method and device for the iontophoretic delivery of a drug | |
AU4398593A (en) | Iontophoretic delivery device and method of hydrating same | |
WO2002098502A3 (en) | Apparatus and methods for facilitating wound healing | |
AU734727B2 (en) | Improvements in and/or relating to delivery devices and their use | |
WO2008028063A3 (en) | Electrode assembly and method of using same | |
MX9606207A (en) | Electrical devices. | |
WO2006064502A3 (en) | Local delivery of drugs or substances using electronic permeability increase | |
WO2006010837A3 (en) | Device for transferring molecules to cells using an electric force | |
HU222607B1 (en) | Miniature valve, device for filling the reservoir, apparatus for the transdermal administration of medicine, method of manufacturing said valve | |
DE69324499T2 (en) | DISCHARGE DEVICE | |
WO2002055058A3 (en) | Flexible microchip devices for ophthalmic and other applications | |
WO2008063338A3 (en) | Chemical compound delivery device and method | |
WO2007101999A3 (en) | Electrostimulation device | |
WO2007146517A3 (en) | System for neural stimulation via lymphatic vessel | |
WO2004096318A3 (en) | Polymer coated device for electrically mediated drug delivery | |
AUPS081502A0 (en) | Connector for drug delivery system | |
EP1351255A3 (en) | Methods and memory structures using tunnel-junction device as control element | |
WO2010053607A3 (en) | Smart fuze guidance system with replaceable fuze module | |
ATE153244T1 (en) | USER ACTIVATED IONTOPHORETIC DEVICE | |
MX170809B (en) | IONTOPHORESIS ELECTRODE |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20220301 |
|
MKLA | Lapsed |
Effective date: 20200831 |