CA2497680A1 - Apparatus for the dispensing of liquids, container cartridge suitable for this, and system comprising the apparatus for the dispensing of liquids and the container cartridge - Google Patents

Apparatus for the dispensing of liquids, container cartridge suitable for this, and system comprising the apparatus for the dispensing of liquids and the container cartridge Download PDF

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Publication number
CA2497680A1
CA2497680A1 CA002497680A CA2497680A CA2497680A1 CA 2497680 A1 CA2497680 A1 CA 2497680A1 CA 002497680 A CA002497680 A CA 002497680A CA 2497680 A CA2497680 A CA 2497680A CA 2497680 A1 CA2497680 A1 CA 2497680A1
Authority
CA
Canada
Prior art keywords
container cartridge
container
housing
section
cartridge according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002497680A
Other languages
French (fr)
Other versions
CA2497680C (en
Inventor
Joerg Schiewe
Bernd Zierenberg
Horst Wergen
Gilbert Wuttke
Stephen Dunne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10241640A external-priority patent/DE10241640A1/en
Application filed by Individual filed Critical Individual
Publication of CA2497680A1 publication Critical patent/CA2497680A1/en
Application granted granted Critical
Publication of CA2497680C publication Critical patent/CA2497680C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0054—Cartridges, i.e. containers specially designed for easy attachment to or easy removal from the rest of the sprayer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/0083—Timers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
    • B05B11/025—Membranes or pistons acting on the contents inside the container, e.g. follower pistons with stepwise advancement of the piston, e.g. for spraying a predetermined quantity of content
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/109—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring
    • B05B11/1091—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring being first hold in a loaded state by locking means or the like, then released
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0027—Means for neutralising the actuation of the sprayer ; Means for preventing access to the sprayer actuation means
    • B05B11/0032—Manually actuated means located downstream the discharge nozzle for closing or covering it, e.g. shutters

Abstract

The invention relates to a propellant gas-free device for discharging liquid s, to a cartridge, which is adapted thereto and which is provided for storing t he liquid, and to the ensemble comprised of both the device and cartridge. The invention consists of a device (1) for supplying pressure and for accommodating a cartridge (10), and of a cartridge (10) inside of which a discharging device (29) is integrated.

Claims (35)

1. Device for the delivery of a predosed quantity of a drug in dissolved or suspended form as a liquid jet or as an aerosol of droplets by delivery of the predosed quantity under pressure by a dispensing facility (29), comprising - an elastic element (15, 16) for the storage of a predetermined quantity of energy - a mobile element (6) to which the predetermined quantity of energy can be fed and which can expose the dosed fluid quantity to a predetermined increase in pressure, characterized in that - means (4, 12, 13, 14, 18, 19, 21, 22, 23, 27) for the respective introduction and removal of a container cartridge (10) containing the drug into and from an accommodation chamber (30) lying in the inside of the device and - means for the feeding of the pressurized drug to a dispensing facility (29) firmly connected to the container cartridge (10) are provided.
2. Device according to claim 1, characterized in that the container cartridge (10) can be introduced into the accommodation chamber (30) via an opening (4) in the housing wall (26) of the device.
3. Device according to claim 1 or 2, characterized in that the container cartridge (10) can be introduced directly into its end-position in the device.
4. Device according to claim 1 or 2, characterized in that the container cartridge (10), after its introduction into the housing opening (4), can be transferred into its end-position by a transport means, in particular a transport carriage (14).
5. Device according to one of claims 1 to 4, characterized in that a part of the housing wall is a constituent of a removable grip (18) which is provided with a holding means (12) for accommodating a container cartridge (10).
6. Device according to one of claims 1 to 5, characterized in that the device has a housing lower section (3), one end of which defines the bottom-side end of the device, a housing middle section (2b) housed rotatable against the housing lower section (3) and a housing upper section (2a), designed vertically swivellable or eccentrically rotatable relative to the housing middle section (2b), with the means (30) for accommodating the container cartridge (10), wherein the end which, in the closed state of the device, is not connected to the housing middle section defines the top-side end of the device.
7. Device according to claim 6, characterized in that the container cartridge (10) can be introduced into a bore (30) passing through the housing upper section (2a).
8. Device according to claim 7, characterized in that there are developed on the bore (30) one stop or more stops beyond which the container cannot be pushed and/or means are developed for guiding the container cartridge (10) optionally up to the stop or stops.
9. Device according to one of the preceding claims 1 to 8, characterized in that the elastic element for the storage of a predetermined quantity of energy is a helical spring (16) which is part of a locking clamping means and via which a drive flange (33), which is connected to a pressure piston (6), is moved vertically.
10. Device according to claim 9, characterized in that the compression spring (16) is located in a compression spring housing (31) which is housed rotatable in the housing middle section and is connected to the housing lower section, the compression spring (16) being tensioned via a gear system when the housing lower section (3) and/or the compression spring housing (31) is rotated against the housing middle section (2b) and moves the drive flange bottom-side and the compression spring remains in the tensioned position via a locking member (34), until a relaxation occurs due to the pressing of the release key (35) connected to the locking member (34).
11. Device according to one of the preceding claims 6 to 10, characterized in that blocking means are developed for blocking the release key (35) that are coupled to the closure mechanism between the housing upper section and housing lower section.
12. Device according to claim 11, characterized in that the blocking means comprise a mobile locking bolt (50) which prevents the horizontal release movement of the locking member (34) and/or of the release key (35).
13. Device according to one of claims 1 to 12, characterized in that the device has closure arrest means (54, 55, 56) which prevent the housing upper section (2a) from being opened as long as the compression spring (16) is not tensioned, and the pressure piston (6) thus projects into the housing upper section (2a).
14. Device according to claim 13 in combination with one of claims 6 to 12, characterized in that the closure arrest means comprise a mobile arrester bolt (56) which prevents the release of the closure key 54 until the pressure piston (6) is in the position defined by the tensioned spring (16).
15. Dimensionally stable, manually not deformable container cartridge (10) with a base part and a top part, the top part being formed by a dispensing facility (29) from which a stock cylinder (40) for accommodating a drug in dissolved or suspended form leads to the bottom of the container cartridge, which is closed by sealing means (59) not indestructibly removable from the container cartridge and/or a container punch (39) movable into the stock cylinder (40), sealing and not projecting outwards beyond the bottom area of the container cartridge, and/or by a rigid baseplate (63).
16. Container cartridge according to claim 15, characterized in that the dispensing facility (29) is closed to the outside by a sealing means (58).
17. Container cartridge according to claim 15 or 16, characterized in that the dispensing facility (29) is held in the top-side opening of the stock cylinder (40) by at least one holder (60).
18. Container cartridge according to one of claims 15 to 17, characterized in that the dispensing facility (29) and/or the holder (60) is (are) held in the top-side opening of the stock cylinder (40) by gluing, welding, ultra[sonic] welding, crimping and/or a screw cap.
19. Container cartridge according to one of claims 15 to 18, characterized in that the container punch (39) is a piston (container piston) or preferably a ball (container ball).
20. Container cartridge according to one of claims 15 to 19, characterized in that the stock cylinder has a filling capacity of at most 100 µl.
21. Container cartridge according to one of claims 15 to 20, characterized in that the stock cylinder has a filling capacity of at most 15 µl.
22. Container cartridge according to one of claims 15 to 21, characterized in that the dispensing facility (29) is a nozzle with an opening.
23. Container cartridge according to one of claims 15 to 21, characterized in that the dispensing facility (29) is a nozzle with at least two openings.
24. Container cartridge according to claim 23, characterized in that the channels leading to the at least two openings are oriented to each other in the direction of the openings, so that liquid jets or aerosol clouds dispensed from the openings collide with each other.
25. Container cartridge according to one of claims 15 to 24, characterized in that the dispensing facility (29) has filter means (45).
26. Container cartridge according to one of claims 15 to 25, characterized in that the dispensing facility (29) consists of at least two parts, each with at least an essentially flat surface, via which the two parts are connected to each other to form a unit, at least one of the surfaces having a microstructure with channels which form at least one liquid inlet into the unit and at least one liquid outlet from the unit, optionally filter means and/or one or more plenum chambers.
27. Container cartridge according to one of claims 15 to 26, characterized in that the container cartridge is not plastically deformable up to a pressure difference between the inside of the stock cylinder and the external surroundings of at least 49 bar.
28. Container cartridge according to one of claims 15 to 27, characterized in that the container has a head region, a shoulder and a belly region, the cross-section of the belly region vertical to the longitudinal axis being larger than the cross-section of the head region vertical to the longitudinal axis.
29. Container cartridge according to one of claims 15 to 28, characterized in that the container has a baseplate which has the largest cross-section of the container vertical to the longitudinal axis.
30. Container cartridge according to one of claims 15 to 28, characterized in that one part of the container has a cross-section, vertical to the longitudinal axis, which is not rotation-symmetrical.
31. System for the delivery of a predosed quantity of a medico-therapeutically and/or medico-prophylactically effective substance in dissolved or suspended form as a liquid jet or an aerosol of droplets by delivery of the predosed quantity of the drug under pressure by a dispensing facility (29), comprising a device according to one of claims 1 to 14 as well as at least one container cartridge according to one of claims 15 to 30.
32. System according to claim 31, characterized in that the accommodation chamber (30) and the container cartridge (10) are developed to fit precisely.
33. System according to claim 31, characterized in that it is a needleless injector.
34. System according to claim 31, characterized in that it is an inhalation device.
35. System according to claim 31, characterized in that it is an atomizer for the application of a spray to the surface of the eye.
CA2497680A 2002-09-05 2003-08-26 Apparatus for the dispensing of liquids, container cartridge suitable for this, and system comprising the apparatus for the dispensing of liquids and the container cartridge Expired - Fee Related CA2497680C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10241640.0 2002-09-05
DE10241640A DE10241640A1 (en) 2002-09-05 2002-09-05 Needle-less syringe or inhaler for administering aqueous or aqueous-alcohol formulations of drugs comprises casing containing spring-loaded piston, into which cartridge with integral diffuser head can be introduced
EP02027030.2 2002-12-03
EP02027030 2002-12-03
PCT/EP2003/009442 WO2004022244A1 (en) 2002-09-05 2003-08-26 Device for discharging liquids, a cartridge suited therefor, and system comprised of the device for discharging liquids and of the cartridge

Publications (2)

Publication Number Publication Date
CA2497680A1 true CA2497680A1 (en) 2004-03-18
CA2497680C CA2497680C (en) 2010-12-07

Family

ID=31979475

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2497680A Expired - Fee Related CA2497680C (en) 2002-09-05 2003-08-26 Apparatus for the dispensing of liquids, container cartridge suitable for this, and system comprising the apparatus for the dispensing of liquids and the container cartridge

Country Status (25)

Country Link
EP (1) EP1536894B1 (en)
JP (1) JP2005537834A (en)
KR (1) KR20050057225A (en)
CN (1) CN100586579C (en)
AR (1) AR041162A1 (en)
AT (1) ATE503587T1 (en)
AU (1) AU2008230008A1 (en)
BR (1) BR0314035A (en)
CA (1) CA2497680C (en)
CO (1) CO5720980A2 (en)
DE (1) DE50313589D1 (en)
EA (1) EA007403B1 (en)
EC (1) ECSP055639A (en)
HK (1) HK1084908A1 (en)
HR (1) HRP20050216A2 (en)
MX (1) MXPA05002348A (en)
MY (1) MY140823A (en)
NO (1) NO20051635L (en)
NZ (2) NZ539128A (en)
PE (1) PE20040389A1 (en)
PL (1) PL375495A1 (en)
RS (1) RS20050192A (en)
TW (1) TWI293577B (en)
UY (1) UY27963A1 (en)
WO (1) WO2004022244A1 (en)

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US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator

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US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US8109414B2 (en) 2008-10-07 2012-02-07 Ing. Erich Pfeiffer Gmbh Discharge device
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
US10220163B2 (en) 2012-04-13 2019-03-05 Boehringer Ingelheim International Gmbh Nebuliser with coding means
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US10894134B2 (en) 2013-08-09 2021-01-19 Boehringer Ingelheim International Gmbh Nebulizer
US11642476B2 (en) 2013-08-09 2023-05-09 Boehringer Ingelheim International Gmbh Nebulizer
US10716905B2 (en) 2014-02-23 2020-07-21 Boehringer Lngelheim International Gmbh Container, nebulizer and use
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator

Also Published As

Publication number Publication date
ATE503587T1 (en) 2011-04-15
NZ539128A (en) 2007-03-30
MXPA05002348A (en) 2005-05-23
AU2003264106A1 (en) 2004-03-29
PE20040389A1 (en) 2004-08-10
EP1536894A1 (en) 2005-06-08
CN100586579C (en) 2010-02-03
JP2005537834A (en) 2005-12-15
EP1536894B1 (en) 2011-03-30
ECSP055639A (en) 2005-07-06
TW200413100A (en) 2004-08-01
WO2004022244A1 (en) 2004-03-18
RS20050192A (en) 2007-06-04
MY140823A (en) 2010-01-29
CA2497680C (en) 2010-12-07
CO5720980A2 (en) 2007-01-31
KR20050057225A (en) 2005-06-16
HRP20050216A2 (en) 2006-06-30
NO20051635L (en) 2005-04-01
EA200500407A1 (en) 2005-10-27
DE50313589D1 (en) 2011-05-12
UY27963A1 (en) 2004-05-31
NZ552261A (en) 2008-08-29
CN1678407A (en) 2005-10-05
PL375495A1 (en) 2005-11-28
AU2003264106B2 (en) 2008-11-06
BR0314035A (en) 2005-07-12
HK1084908A1 (en) 2006-08-11
AU2008230008A1 (en) 2008-11-27
EA007403B1 (en) 2006-10-27
AR041162A1 (en) 2005-05-04
TWI293577B (en) 2008-02-21

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