CA2504397A1 - Meniscal repair scaffold - Google Patents
Meniscal repair scaffold Download PDFInfo
- Publication number
- CA2504397A1 CA2504397A1 CA002504397A CA2504397A CA2504397A1 CA 2504397 A1 CA2504397 A1 CA 2504397A1 CA 002504397 A CA002504397 A CA 002504397A CA 2504397 A CA2504397 A CA 2504397A CA 2504397 A1 CA2504397 A1 CA 2504397A1
- Authority
- CA
- Canada
- Prior art keywords
- cell growth
- conduit flap
- tissue
- growth conduit
- scaffold
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
- A61F2/3872—Meniscus for implantation between the natural bone surfaces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/10—Materials or treatment for tissue regeneration for reconstruction of tendons or ligaments
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Surgical Instruments (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Methods and apparatus for treating meniscal tissue damage are disclosed, including a biocompatible meniscal repair device comprising a biocompatible tissue repair scaffold and a cell growth conduit flap. The tissue repair scaffold is adapted to be placed in contact with a defect in the meniscus and can preferably provide a structure for supporting meniscal tissue and/or encouraging tissue growth. The cell growth conduit flap, which is attached to the tissue repair scaffold, allows communication between the synovium and the tissue repair scaffold.
Claims (29)
1. A biocompatible meniscal repair device, comprising:
a biocompatible tissue repair scaffold adapted to be placed in contact with a defect in a meniscus; and a cell growth conduit flap attached to the tissue repair scaffold, the cell growth conduit flap being adapted to contact a tibial surface and communicate biological materials to a tissue defect in the meniscus.
a biocompatible tissue repair scaffold adapted to be placed in contact with a defect in a meniscus; and a cell growth conduit flap attached to the tissue repair scaffold, the cell growth conduit flap being adapted to contact a tibial surface and communicate biological materials to a tissue defect in the meniscus.
2. The repair device of claim 1, wherein the cell growth conduit flap provides a conduit that enables cells and nutrients to travel from the synovium to the tissue repair scaffold and the tissue defect in the meniscus.
3. The repair device of claim 2, wherein the cell growth conduit flap is adapted to contact the synovium.
4. The repair device of claim 1, wherein the tissue repair scaffold is constructed from a bioabsorable material.
5. The repair device of claim 1, wherein the tissue repair scaffold and the cell growth conduit flap are constructed from different materials.
6. The repair device of claim 1, wherein the tissue repair scaffold and the cell growth conduit flap are constructed from the same materials.
7. The repair device of claim 6, wherein the tissue repair scaffold and the cell growth conduit flap include at least one polymer derived from monomers selected from the group consisting of glycolide, lactide, and dioxanone.
8. The repair device of claim 1, wherein the tissue repair scaffold and the cell growth conduit flap include polydioxanone.
9. The repair device of claim 1, wherein the tissue repair scaffold and the cell growth conduit flap include a copolymer of glycolide and L-lactide.
10. The repair device of claim 1, wherein the tissue repair scaffold is formed from at least one material selected from the group consisting of natural polymers, synthetic polymers, and combinations thereof.
11. The repair device of claim 1, further comprising a viable tissue disposed on or within the tissue repair scaffold and effective to integrate with native tissue adjacent to the tissue repair scaffold.
12. The repair device of claim 1, further comprising at least one bioactive substance effective to stimulate cell growth.
13. The repair device of claim 12, wherein the bioactive substance is selected from the group consisting of a platelet rich plasma, cartilage-derived morphogenic proteins, recombinant human growth factors, and combinations thereof.
14. The repair device of claim 1, wherein the tissue repair scaffold and the cell growth conduit flap are formed from a single piece.
15. The repair device of claim l, wherein the cell growth conduit flap is oriented such that it is substantially perpendicular relative to the tissue repair scaffold.
16. The repair device of claim 1, wherein the cell growth conduit flap and the tissue repair scaffold are oriented with respect to each other such that they form a "T"
shape.
shape.
17. The repair device of claim 1, wherein the cell growth conduit flap and the tissue repair scaffold are oriented with respect to each other such that they from a "L"
shape.
shape.
18. The repair device of claim 1, wherein the cell growth conduit flap has a thickness that is less than the thickness of the tissue repair scaffold.
19. The repair device of claim 1, wherein the density of the cell growth conduit flap is in the range of about 150 mg/cc to 350 mg/cc.
20. The repair device of claim 1, wherein the cell growth conduit flap has a void volume in the range of about 50 % to 95 %.
21. A method of surgically repairing meniscal defects, comprising:
providing a tissue repair scaffold having attached thereto a cell growth conduit flap;
positioning the tissue repair scaffold in contact with a defect in a meniscus while positioning the cell growth conduit flap in contact with a tibial surface; and fixing the tissue repair scaffold in position, wherein the cell growth conduit flap allows cells and nutrients to travel to the defect in the meniscus and thereby encourage healing of the meniscus.
providing a tissue repair scaffold having attached thereto a cell growth conduit flap;
positioning the tissue repair scaffold in contact with a defect in a meniscus while positioning the cell growth conduit flap in contact with a tibial surface; and fixing the tissue repair scaffold in position, wherein the cell growth conduit flap allows cells and nutrients to travel to the defect in the meniscus and thereby encourage healing of the meniscus.
22. The method of claim 21, further comprising the step of rasping the meniscus before positioning the cell growth conduit flap.
23. The method of claim 21, further comprising the step of rasping the synovium before positioning the cell growth conduit flap.
24. The method of claim 21, further comprising placing the cell growth conduit flap in contact with the synovium.
25. A method of surgically repairing meniscal defects, comprising:
providing a cell growth conduit flap;
positioning the cell growth conduit flap in contact with a tissue defect in a meniscus and in contact with a tibial surface; and fixing cell growth conduit flap in position, wherein the cell growth conduit flap is effective to allow cells and nutrients to travel to the defect in the meniscus and thereby promote healing of the meniscus.
providing a cell growth conduit flap;
positioning the cell growth conduit flap in contact with a tissue defect in a meniscus and in contact with a tibial surface; and fixing cell growth conduit flap in position, wherein the cell growth conduit flap is effective to allow cells and nutrients to travel to the defect in the meniscus and thereby promote healing of the meniscus.
26. The method of claim 25, wherein the cell growth conduit flap is positioned in contact the synovium.
27. The method of claim 25, wherein the cell growth conduit flap provides a conduit that enables cells and nutrients to travel from the synovium to the tissue defect in a meniscus.
28. The method of claim 25, further comprising the step of rasping the meniscus before positioning the cell growth conduit flap.
29. The method of claim 25, further comprising the step of rasping the synovium before positioning the cell growth conduit flap.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/828,841 | 2004-04-20 | ||
| US10/828,841 US8657881B2 (en) | 2004-04-20 | 2004-04-20 | Meniscal repair scaffold |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2504397A1 true CA2504397A1 (en) | 2005-10-20 |
| CA2504397C CA2504397C (en) | 2010-07-06 |
Family
ID=34940917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2504397A Expired - Fee Related CA2504397C (en) | 2004-04-20 | 2005-04-20 | Meniscal repair scaffold |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8657881B2 (en) |
| EP (1) | EP1602345B1 (en) |
| JP (1) | JP4549919B2 (en) |
| AU (1) | AU2005201392B8 (en) |
| CA (1) | CA2504397C (en) |
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| CA2504397C (en) | 2010-07-06 |
| EP1602345A1 (en) | 2005-12-07 |
| JP4549919B2 (en) | 2010-09-22 |
| AU2005201392A8 (en) | 2010-04-15 |
| AU2005201392A1 (en) | 2005-11-03 |
| AU2005201392B2 (en) | 2006-09-21 |
| US20050234549A1 (en) | 2005-10-20 |
| EP1602345B1 (en) | 2011-05-25 |
| AU2005201392B8 (en) | 2010-04-15 |
| JP2005305162A (en) | 2005-11-04 |
| US8657881B2 (en) | 2014-02-25 |
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