CA2505520A1 - Protein-stabilized liposomal formulations of pharmaceutical agents - Google Patents
Protein-stabilized liposomal formulations of pharmaceutical agents Download PDFInfo
- Publication number
- CA2505520A1 CA2505520A1 CA002505520A CA2505520A CA2505520A1 CA 2505520 A1 CA2505520 A1 CA 2505520A1 CA 002505520 A CA002505520 A CA 002505520A CA 2505520 A CA2505520 A CA 2505520A CA 2505520 A1 CA2505520 A1 CA 2505520A1
- Authority
- CA
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- Prior art keywords
- agent
- protein
- pharmaceutical agent
- emulsion
- lipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract 24
- 239000008177 pharmaceutical agent Substances 0.000 title claims 17
- 238000009472 formulation Methods 0.000 title claims 16
- 238000000034 method Methods 0.000 claims abstract 39
- 102000004169 proteins and genes Human genes 0.000 claims abstract 10
- 108090000623 proteins and genes Proteins 0.000 claims abstract 10
- 239000002502 liposome Substances 0.000 claims abstract 5
- 150000002632 lipids Chemical class 0.000 claims 14
- 239000000839 emulsion Substances 0.000 claims 6
- 235000018102 proteins Nutrition 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- -1 poly(ethylene glycol) Polymers 0.000 claims 5
- 239000007864 aqueous solution Substances 0.000 claims 4
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000002105 nanoparticle Substances 0.000 claims 3
- 150000003904 phospholipids Chemical class 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
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- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 2
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- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 2
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- KSCFJBIXMNOVSH-UHFFFAOYSA-N dyphylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1N(CC(O)CO)C=N2 KSCFJBIXMNOVSH-UHFFFAOYSA-N 0.000 claims 2
- CTSPAMFJBXKSOY-UHFFFAOYSA-N ellipticine Chemical compound N1=CC=C2C(C)=C(NC=3C4=CC=CC=3)C4=C(C)C2=C1 CTSPAMFJBXKSOY-UHFFFAOYSA-N 0.000 claims 2
- HESCAJZNRMSMJG-HGYUPSKWSA-N epothilone A Natural products O=C1[C@H](C)[C@H](O)[C@H](C)CCC[C@H]2O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C HESCAJZNRMSMJG-HGYUPSKWSA-N 0.000 claims 2
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 2
- YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 claims 2
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Abstract
The present invention relates to protein stabilized liposomes. Specifically, the present invention discloses compositions and methods for protein stabilized liposomes, the creation of protein stabilized liposomes, and the administration of protein stabilized liposomes.
Claims (38)
1. A method of preparing a protein-stabilized lipid formulation containing at least one lipophilic pharmaceutical agent, the method comprising:
(a) preparing an organic solution comprising one or more phospholipids;
(b) mixing at least one pharmaceutical agent into said organic solution;
(c) infusing said organic mixture into an aqueous solution comprising an emulsion-forming protein to form an emulsion; and (d) removing organic solvent from said emulsion to form the protein-stabilized lipid formulation.
(a) preparing an organic solution comprising one or more phospholipids;
(b) mixing at least one pharmaceutical agent into said organic solution;
(c) infusing said organic mixture into an aqueous solution comprising an emulsion-forming protein to form an emulsion; and (d) removing organic solvent from said emulsion to form the protein-stabilized lipid formulation.
2. The method of claim 1, wherein the lipid formulation comprises protein-stabilized liposomes.
3. The method of claim 2, wherein the liposome-forming components further includes cholesterol.
4. The method of claim 2, wherein the liposome-forming components further includes a PEG-phospholipid.
5. The method of claim 4, wherein said PEG-phospholipid comprises poly(ethylene glycol)-derivatized distearoylphosphatidylethanolamine (PEG-DSPE) and/or poly(ethylene glycol)-derivatized ceramides (PEG-CER)
6. The method of claim 1, wherein the lipophilic pharmaceutical agent is further identified as a substantially water insoluble pharmaceutical agent.
7. The method of claim 1, wherein the phospholipid and lipophilic pharmaceutical agent are included in the organic solution at a ratio ranging from about 0.01:25 to about 1:10 drug:lipid (w/w).
8. The method of claim 1 wherein said emulsion forming protein comprises an albumin, immunoglobulin, casein, insulin, hemoglobin, lysozyme, immunoglobulin, .alpha.-macroglobulin, fibronectin, vitronectin, fibrinogen, lipase, or enzyme.
9. The method of claim 8, wherein the emulsion forming protein is an albumin.
10. The method of claim 1, wherein said aqueous solution is at a pH of between about 6.0 and 7.6.
11. The method of claim 1, wherein said emulsion-forming protein comprises from about 0.1% to about 20% (w/v) of the aqueous solution.
12. The method of claim 11, wherein said emulsion-forming protein comprises from about 1% to about 10% (w/v) of the aqueous solution.
13. The method of claim 1, wherein the emulsion is formed by steps that comprise:
(a) agitating said mixture at between about 1000 and about 24,000 revolutions per minute;
and (b) subjecting the agitated mixture to high pressure microfluidization or homogenization at 5,000 to 30,000 PSI.
(a) agitating said mixture at between about 1000 and about 24,000 revolutions per minute;
and (b) subjecting the agitated mixture to high pressure microfluidization or homogenization at 5,000 to 30,000 PSI.
14. The method of claim 13, wherein the emulsion is formed by steps that comprise:
(a) agitating said mixture at between about 3000 and about 10,000 revolutions per minute;
and (b) subjecting the agitated mixture to high pressure microfluidization or homogenization at 10,000 to 30,000 PSI.
(a) agitating said mixture at between about 3000 and about 10,000 revolutions per minute;
and (b) subjecting the agitated mixture to high pressure microfluidization or homogenization at 10,000 to 30,000 PSI.
15. The method of claim 13, wherein the mixture is agitated using a homogenizer.
16. The method of claim 15, wherein the mixture is agitated using a rotary homogenizer.
17. The method of claim 1, wherein the lipid formulation is filtered.
18. The method of claim 17, wherein the lipid formulation is filtered through a 0.20 or 0.22 micron filter.
19. The method of claim 1, wherein the lipid formulation is lyophilized to provide a powder suitable for reconstitution in an aqueous suspension.
20. The method of claim 19, wherein the lipid formulation is lyophilized in the presence of one or more cryoprotectants.
21. The method of claim 20 wherein the cryoprotectant is sucrose, mannitol or trehalose.
22. The method of claim 1 wherein the pharmaceutical agent comprises a cardiovascular drug, respiratory drug, sympathomimetic drug, cholinomimetic drug, adrenergic or adrenergic neuron blocking drug, analgesic/antipyretic, anesthetic, antiasthamatic, antibiotic, antidepressant, antidiabetic, antifungal agent, antihypertensive agent, anti-inflammatory, antineoplastic, antianxiety agent, immunosuppressive agent, antimigraine agent, sedatives/hypnotic, antianginal agent, antipsychotic agent, antimanic agent, antiarrhythmic, antiarthritic agent, antigout agent, anticoagulant, thrombolytic agent, antifibrinolytic agent, hemorheologic agent, antiplatelet agent, anticonvulsant, antiparkinson agent, antihistamine/antipruritic, agent useful for calcium regulation, antibacterial agent, antiviral agent, antimicrobial, anti-infective, bronchodialator, hormone, hypoglycemic agent, hypolipidemic agent, protein, nucleic acid, agent useful for erythropoiesis stimulation, antiulcer/antireflux agent, antinauseant/antiemetic, oil-soluble vitamin, mitotane, visadine, halonitrosourea, anthrocycline or ellipticine.
23. The method of claim 22, wherein the pharmaceutical agent is Proscillaridin-A, oleandrin, digitoxin, digoxin, odoroside-A, colchicine, colchicine derivatives, ara-C
derivatives, diphyllin, justicidin-A, diphyllin derivatives, cleistanthin A, chloroquine, amphotericin B, paclitaxel, docetaxel, cyclosporine, camptothecin, 7-ethyl-10-hydroxy-camptothecin, 10-hydroxy-camptothecin, a camptothecin derivative, podophyllotoxin, podophyllotoxin derivatives, vinblastine, vincristine, dihydroartemisinin, mitoxantrone, amphotericin B, epothilone-A, epothilone-B, epothilone-C, epothilone-D, an epothilone derivative, a benz[c]-phenanthridine alkaloid derivative, a chelerythrine alkaloid derivative or cisplatin.
derivatives, diphyllin, justicidin-A, diphyllin derivatives, cleistanthin A, chloroquine, amphotericin B, paclitaxel, docetaxel, cyclosporine, camptothecin, 7-ethyl-10-hydroxy-camptothecin, 10-hydroxy-camptothecin, a camptothecin derivative, podophyllotoxin, podophyllotoxin derivatives, vinblastine, vincristine, dihydroartemisinin, mitoxantrone, amphotericin B, epothilone-A, epothilone-B, epothilone-C, epothilone-D, an epothilone derivative, a benz[c]-phenanthridine alkaloid derivative, a chelerythrine alkaloid derivative or cisplatin.
24. The method of claim 1, wherein said one or more phospholipids comprise one or more of hydrogenated soy phosphatidylcholine (HSPC), egg phosphatidylcholine (EPC), phosphatidylethanolamine (PE), phosphatidylglycerol (PG), phosphatidylinsitol (PI) monosialogangolioside, spingomyelin (SPM), distearoylphosphatidylcholine (DSPC), dimyristoylphosphatidylcholine (DMPC), or dimyristoylphosphatidylglycerol (DMPG).
25. The method of claim 1, wherein the ratio of pharmaceutical agent to lipid-protein ranges from about 0.0005 to about 1 (w/w).
26. The method of claim 25, wherein the ratio of pharmaceutical agent to lipid-protein ranges from about 0.0005 to about 0.5 (w/w).
27. The method of claim 26, wherein the ratio of pharmaceutical agent to lipid-protein ranges from about 0.001 to about 0.1 (w/w).
28. The method of claim 1, wherein the lipid formulation is subjected to high shear stress to reduce particle size.
29. The method of claim 1, wherein the lipid formulation is defined further as comprising nanoparticles having size less than about 220 nm.
30. The method of claim 29, wherein the nanoparticles have a size of between about 80-160 nm.
31. The method of claim 30, wherein the nanoparticles have a size of between about 100-120 nm.
32. A protein-stabilized lipid formulation comprising a lipophilic pharmaceutical agent, the formulation prepared by the process of any one of claim 1 - 31.
33. A method of treating a disease in a patient comprising:
(a) obtaining a lipophilic pharmaceutical agent drug indicated for treatment of the disease;
(b) preparing a protein-stabilized lipid formulation of said pharmaceutical agent; and (c) administering an amount of the lipid formulated pharmaceutical agent to said patient that is effective to treat the disease.
(a) obtaining a lipophilic pharmaceutical agent drug indicated for treatment of the disease;
(b) preparing a protein-stabilized lipid formulation of said pharmaceutical agent; and (c) administering an amount of the lipid formulated pharmaceutical agent to said patient that is effective to treat the disease.
34. The method of claim 33, wherein the protein-stabilized lipid formulation of said pharmaceutical agent is prepared in accordance with claim 1.
35. The method of claim 33, wherein the disease is a hyperproliferative disease and the pharmaceutical agent is an anti-hyperproliferative agent.
36. The method of claim 33, wherein the formulation is administered parenterally.
37. The method of claim 36, wherein the formulation is administered by slow infusion or bolus injection.
38
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-
2003
- 2003-11-06 EP EP03781768A patent/EP1585504A4/en not_active Withdrawn
- 2003-11-06 CA CA2505520A patent/CA2505520C/en not_active Expired - Lifetime
- 2003-11-06 JP JP2004551766A patent/JP2006508126A/en active Pending
- 2003-11-06 WO PCT/US2003/035297 patent/WO2004043363A2/en active Application Filing
- 2003-11-06 US US10/703,187 patent/US7179484B2/en not_active Expired - Lifetime
- 2003-11-06 AU AU2003287526A patent/AU2003287526A1/en not_active Abandoned
-
2007
- 2007-01-03 US US11/619,526 patent/US20070166368A1/en not_active Abandoned
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US20040247660A1 (en) | 2004-12-09 |
CA2505520C (en) | 2012-07-17 |
WO2004043363A8 (en) | 2005-07-28 |
AU2003287526A1 (en) | 2004-06-03 |
EP1585504A2 (en) | 2005-10-19 |
WO2004043363A2 (en) | 2004-05-27 |
US7179484B2 (en) | 2007-02-20 |
EP1585504A4 (en) | 2009-07-15 |
AU2003287526A8 (en) | 2004-06-03 |
JP2006508126A (en) | 2006-03-09 |
WO2004043363A3 (en) | 2004-08-12 |
US20070166368A1 (en) | 2007-07-19 |
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