CA2508113A1 - Information notification sample processing system and methods of biological slide processing - Google Patents

Information notification sample processing system and methods of biological slide processing Download PDF

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Publication number
CA2508113A1
CA2508113A1 CA002508113A CA2508113A CA2508113A1 CA 2508113 A1 CA2508113 A1 CA 2508113A1 CA 002508113 A CA002508113 A CA 002508113A CA 2508113 A CA2508113 A CA 2508113A CA 2508113 A1 CA2508113 A1 CA 2508113A1
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Prior art keywords
sample processing
information
automated sample
automated
processing system
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CA002508113A
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French (fr)
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CA2508113C (en
Inventor
Gordon Feingold
Marc Key
Rosanne Welcher
John Favuzzi
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Dako Denmark ApS
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    • G01N35/00732Identification of carriers, materials or components in automatic analysers
    • GPHYSICS
    • G01MEASURING; TESTING
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    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • GPHYSICS
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    • G01N2035/009Displaying information to the operator alarms, e.g. audible
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    • GPHYSICS
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    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract

A sample processing system (101) that may be automated and methods are disclosed where sample(s) (198) are arranged on a carrier element (197) and a process operation control system (171) automatically processes the sample(s) perhaps robotically with an operationally-influential exteriorly-consequential information monitor (402) or a data capture element (414). Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element (404) may cause notification of a person at some display (415) that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to "watch" simulated operation in real time or long after completion of the actual processing.

Description

INFORMATION NOTIFICATION SAMPLE PROCESSING
SYSTEM AND METHODS OF BIOLOGICAL SLIDE PROCESSING

This application relates to the field of sample processing systems and methods of automatically monitoring and notifying of certain information for the processing of samples or the process system. The present invention may be directed to the automated processing, treatment, or even staining of samples arranged on carriers, such as slides, and in some embodiments, directed to the continuous or batch processing of samples and carriers. Embodiments may further relate to control systems for sample processing and data input, acquisition, maintenance, and retrieval for sample processing.
Applications to which the present invention may especially~relate include irnmunohistochemistry, in-situ hybridization, fluorescent in-situ hybridization, special staining, and cytology, as well as potentially other chemical and biological applications.
BACKGROUND
Sample processing in immunohistochemical (IHC) applications and in other chemical and biological analyses may require one or a number of various processing sequences or protocols as part of an analysis of one or more samples. The sample processing sequences or protocols may be defined by the individual or organization requesting an analysis, such as a pathologist or histologist of a hospital, and may be further defined by the dictates of a particular analysis to be performed.
In preparation for sample analysis, a biological sample may be acquired by known sample acquisition techniques and may comprise, for example in IHC
applications, tissues generally or even in some applications one or a plurality of isolated cells, such as in microarray samples, and may be presented on a sample carrier including but not limited to microscope slides. Furthermore, the sample may be presented on the carrier variously and potentially in some form of preservation. As one example, a sample such as a layer or slice of skin may be preserved in formaldehyde and presented on a Garner with one or more paraffin or other chemical layers infiltrating the sample.

Immunologic applications, for example, may require processing sequences or protocols that comprise steps such as deparaffmization, target retrieval, reagent application, and staining, especially for in-situ hybridization (ISH) techniques. In some applications, these steps may have been performed manually, potentially creating a time-s intensive protocol and necessitating personnel to be actively involved in the sample processing. Even when performed automatically, there have been inefficiencies in such systems. Attempts have been made to automate sample processing to address the need for expedient sample processing and a less manually burdensome operation.
However, such previous efforts may have not fully addressed certain specific needs for an automated sample processing system. Previous efforts to automate sample processing may be deficient in several aspects that prevent more robust automated sample processing, such as: the lack of sufficient computer control and monitoring of sample processing; the lack of information sharing for processing protocol and processing status, especially for individual samples; the lack of practical information input and process definition entry capabilities; the lack of diagnostic capabilities; and the lack of real-time or adaptive capabilities for multiple sample batch processing.
Past efforts at automated sample processing for samples presented on carriers such as slides, such as US Patent No. 6352861 to Ventana Medical Systems, Inc. and US
Patent No. 5839091 to LabVision Corporation, have not afforded the various advantages and other combinations of features as presented herein.
One of the various aspects that may be significant to users of automated process systems is that of handling information related to the process, the substances used in processing, or even the process instrument itself. In this regard, it has often been considered that operators have to have particular knowledge and skills in order to assure the integrity of the process or instrument or result. Perhaps as a result of this fact, human error was introduced into the system. The present invention seeks to reduce such effects to some degree and seeks to provide a system that may be considered more user, operator, supplier, or manufacturer friendly.
DISCLOSURE OF INVENTION
The present invention presents an automated sample processing system that may greatly improve operation of automated sample processing from several perspectives. It
2 may act to monitor information existing relative to the sample processing events and materials and may automatically inform those in a position to need to know. It also may capture and store high levels of detail relative to the sample processing events so users, recipients, or even maintenance personnel may have ready and certifiable access to what S occurred. As described, sample processing can be accomplished as disclosed herein. In providing this disclosure, it should be understood that the various examples and designs disclosed for sample processing and other disclosed techniques, are not meant to limit the present invention to any particular embodiment, whether apparatus, method, or otherwise.
These descriptions are provided rather to describe various sample processing techniques in a manner in which the present invention can be understood. The descriptions incorporated by reference and the various examples should not be construed to limit the present invention to only such techniques. This disclosure, however, may be understood to incorporate the various techniques in the context of the various embodiments of the presentinvention.

The techniques and systems of sample processing are addressed in a fashion that may provide the processing of one or more samples or of a plurality of groups of one or more samples in sequential or non-sequential fashion. Processing of samples may be determined by the protocol to be followed for each sample or a protocol for multiple samples. Aspects of the present invention may be especially applicable to sample processing having one or a plurality of processing steps to be performed on one, a portion, or an entirety of samples, such protocols identified in some instances by individual carriers presenting the samples or by the individual samples themselves. As mentioned, the present invention may be especially applicable to immunohistochemistry 2S (IHC) techniques, as well as in-situ hybridization (ISH) and fluorescent in-situ hybridization (FISH), special staining of samples, and microarrays; especially techniques incorporating target retrieval or the staining of samples. Furthermore, embodiments may be directed to processing sequences addressing issues of processing control.
Embodiments of the invention may further relate to automated control systems for sample processing. Embodiments may also be directed to data acquisition, input, maintenance, and retrieval for sample processing, as well as information sharing of processing protocol and processing information, and real-time or adaptive capabilities for processing.
3 To disclose the foregoing and other objects and in accordance with the purposes of the present invention, as broadly embodied and described herein, the present invention is characterized in various claims and in explanatory disclosure. None of these should be understood as limiting. Further, all claims presented at any time are incorporated in the specification to afford all opportunities of presentation. Claims potentially to be pursued for some of the initially presented aspects of the invention may include any aspects described.
To achieve the foregoing and other objects of invention, and as may be further disclosed and claimed throughout this description, the invention may comprise an automated sample processing system comprising a plurality of drawers, a plurality of sample Garner elements that may even be each removably configured with one of the drawers, and an adaptive or other sample processing control system. The sample Garners may be both movable and removable. The sample processing control system may 1 S automate the sample processing system such that one or more samples may be processed according to one or more protocols, potentially indicated by information on slides or otherwise input to the system. This sample processing may comprise one or more sampling protocols and steps, such as deparaffinization, target retrieval, and staining.
A sensor may be provided in some embodiments that may automatically identify information from one or more samples, sample Garners, or slides. In embodiments, protocol information may be provided or made available by the sample processing control system. The sample processing system may then process one or more samples or perhaps slides, or one or more batches of slides, concurrently, sequentially, or in any other temporal fashion, potentially in accordance with protocol information previously provided for a sample by a user or other decision maker. This information can then be made available for use by the sample processing control system. Sample batches or individual slides may even be inserted or removed during processing protocol steps by the control and monitoring accomplished by the adaptive sample processing control system.
Another embodiment of the present invention that may achieve the foregoing and other objects of invention may comprise a method of sample processing, comprising the steps of accessing at least one of a plurality of samples or sample drawers, providing at least one sample carrier or perhaps a sample carrier retainment assembly configured with at least one sample, configuring at least one of the drawers with the at least one sample
4 carrier, and adaptively processing the sample. The step of processing or perhaps even adaptive processing may be applied to automate the processing of samples and may allow for either or both continuous or batch processing of samples or slides. It may also afford multiple independent sample or slide processing and in some embodiments slide processing to process each slide independently.
Embodiments of the invention may further comprise a method of automated sample processing, comprising the steps of: acquiring or accepting or accessing information such as protocol or reagent information, transmitting such information to at least one sample processing system or even a stand alone processing system, and processing samples. Furthermore, embodiments may provide: for handling, maintaining, sharing, and using~the sample processing information. These and other aspects may be provided for individual samples or multiple batch processing, and in a real-time manner.
It may also be accomplished in and adaptive manner, perhaps for multiple batch processing or the like.
Again, as mentioned, many of the various aspects of the present invention are applicable to immunohistochemistry (IHC), as well as in-situ hybridization (ISH) and fluorescent in-situ hybridization (FISH), special staining of samples, microarray processes, and techniques incorporating target retrieval or the staining of samples, Furthermore, embodiments are directed to processing sequences addressing issues of processing control, and may be particularly applied to slide processing systems.
BRIEF DESCRIPTION OF THE DRAWINGS
The accompanying figures, are incorporated in and form a part of the description, illustrate some of the preferred embodiments of the present invention.
Together with the written description and disclosures of the specification, they serve to explain principles of the invention and to enable each of the disclosed embodiments.
Figure 1 is a depiction of an embodiment of an overall system incorporating some of the features of the invention.
Figure 2 is a depiction of an embodiment of a portion of a sample carrier assembly of one embodiment of the invention.
Figure 3 is a depiction of an embodiment of a robotic movement aspect of one embodiment of the invention.
5 Figure 4 is a flow chart of some representative process steps of an embodiment of the invention.
Figure 5 is a block diagram of an embodiment of the invention.
Figure 6 is a depiction of an embodiment of a device incorporating some of the features of the invention.
Figure 7 is a depiction of an embodiment connecting one stainer with one manager & server and one label printer.
Figure 8 is a depiction of an embodiment connecting multiple stainers with multiple managers and multiple label printers.
Figure 9 is a depiction of an embodiment connecting a system to a lab network and lab information system.
Figure 10 is a block diagram showing some of the internal software features. ' Figure 11 is a description of representative deparaffinization steps of an embodiment of the invention.
BEST MODES FOR CARRYING OUT THE INVENTION
The following descriptions are provided to describe various embodiments of the present invention in a manner to facilitate a more detailed understanding some of the inventive features. The variously described examples and preferred embodiments should not be construed to limit the present invention to only the explicitly described systems, techniques, and applications. This description may further be understood to incorporate the various systems, techniques, and applications, both singularly and in various combinations consistent with the various inventive features and embodiments of the present invention. Accordingly, the following is a detailed description of a number of specific embodiments of the invention.
Figure 1 shows one embodiment of a sample processing system 101 in accordance with the present invention. The sample processing system 101 is configured to achieve an appropriate sequence of events that achieves a desired result to some degree. In achieving this sequence in an automated fashion to some degree the sample processing system is deemed an automated sample processing system and achieves automatic processing of at least one sample. This automated sequence as well as other aspects of the invention may be controlled by hardware, software, or some combination of them to accomplish a desired sequence with limited human intervention. Regardless how
6 achieved, the automated control may be provided by a process operation control system 171 to direct the various activities. As shown in figure 10, this (as well as other functionalities discussed) may be software programming or subroutines; again, it may also include hardware or the like. The sample 198 processed may be any material, but is most likely a biologic material such as a biological sample or a biological specimen, perhaps such as a histological sample, e.g. tissue and cell specimens, cells, collections of cells, or tissue samples, the definition to include cell lines, proteins and synthetic peptides, tissues, cell preps, cell preparations, blood, bodily fluids, bone marrow, cytology specimens, blood smears, thin-layer preparations, and micro arrays.
It should also be understood to include slide-based biological samples. As used, a sample may be arranged on a carrier element 197 such as a slide, or microscope slide, or the like that may maintain the sample's position or integrity. The carrier element 197 may be configured to move and thus reposition the sample 198. As such, it may be considered a movable carrier element. In processing a slide, the automated sample processing system may serve as an automated slide processing system.
The automated sequence may involve a significant number of steps. In fact each process can itself require many automated movements to achieve its goal. As but one example, the seemingly simple act of merely placing a stain on a sample or a slide can require a surprising number of physical steps. Each of these may involve different valves, motors, switches, relays, or the like. This seemingly simple act can involve:
beginning X-movement of a robot head;
moving the robot head an appropriate distance along an X-axis for a probe wash location;
ending X-movement of the robot head;
beginning Y-movement of a robot head;
moving the robot head an appropriate distance along an Y-axis for a probe wash location;
ending Y-movement of the robot head;
beginning Z-movement of a robot head;
lowering a probe tip into a wash area;
ending Z-movement of the robot head;
switch a valve to activate a probe wash source;
open a valve to begin flow of a wash liquid from the probe wash source;
wash the probe;
7 close a valve to end flow of a wash liquid from the probe wash source;
beginning Z-movement of a robot head;
raising the probe tip;
ending Z-movement of the robot head;
beginning X-movement of a robot head;
moving a robot head an appropriate distance along an X-axis for a desired stain container;
ending X-movement of the robot head;
beginning Y-movement of a robot head;
moving a robot head an appropriate distance along an Y-axis for a desired stain container;
ending Y-movement of the robot head;
beginning Z-movement of a robot head;
lowering the probe tip over a desired stain container;
ending Z-movement of the robot head; ' switch a valve to utilize a stain aspiration pressure source;
open a valve to begin access to the stain aspiration pressure source;
aspirate stain;
close a valve to end access to the stain aspiration pressure source;
beginning Z-movement of a robot head;
raising the stain containing probe tip;
ending Z-movement of the robot head;
beginning X-movement of a robot head;
moving a robot head an appropriate distance along an X-axis for a particular slide;
ending X-movement of the robot head; ' beginning Y-movement of a robot head;
moving a robot head an appropriate distance along an Y-axis for a particular slide;
ending Y-movement of the robot head;
beginning Z-movement of a robot head;
lowering the stain containing probe tip over a particular slide;
ending Z-movement of the robot head;
switch a valve to utilize a stain emission pressure source;
open a valve to begin access to the stain emission pressure source;
emit stain;
close a valve to end access to the stain emission pressure source;
8 beginning Z-movement of a robot head;
raising the empty probe tip; and ending Z-movement of the robot head.
Each of these type of operations or actions may be relevant to understanding an instrument's operation. Further, each of these types of operations or even a lesser set of significant events may be considered important details of the sample process operation.
As explained later, it may be valuable to capture information relative to a significant number of these actions such as all of these operations, some subset of these operations, one-half of these operations, one-third of these operations, or the like.
Further, even the nature or type of the events that may be if interest may be varies. In general, any event that may indicate the propriety of operation or processing may be a subject.
Naturally in order to achieve automated processing it will be necessary to schedule the various sample process or process operations desired. This can be achieved by an item of software or the like that acts as a multiple event scheduler 401.
A particular design of a system may include cabinet sections 102 that may form outer portions of the system and serve to address general structural considerations of the system (a top cabinet section is not shown in Figure 1). The sample processing system may also comprise a plurality of drawers 104 used for the handling and processing of samples and sample carriers such as slides, potentially microscope slides.
Other sample Garners may be accommodated consistent with the present invention. Each drawer may be configured to accommodate Garner retainment assemblies that hold one or, most likely, a number of the particular carriers, slides, or samples involved.
In holding slides the carrier retainment assembly serves as a slide retainment assembly 106. There may also be carrier racks, modules, or magazines encompassed within each of the two broad terms. As one embodiment of a sample carrier retainment assembly, a slide retainxnent assembly 106 is shown in Figure 2. The slide retainment assembly, and indeed the generic carrier retainment assembly may comprise a slide rack, module, or a number of magazines. The slide retainment assembly 106 may be configured to accommodate a plurality of slides in at least one configuration in corresponding sample Garner retention devices lOg. The sample carrier retainment assemblies, are utilized in the processing of samples as further described below. It should be further noted that the sample Garner retainment assembly can be removably configured with the drawers 104, and may be stackable or nested within other retainment assemblies.
9 The general sample processing system 101, and even one or more drawers 110 in the sample processing system 101 may accommodate processing materials such as reagent containers 199 for sample processing, also further described below. A
processing material retainment assembly, such as a container rack 111, shown in Figure 1, may be utilized to accommodate reagent containers 199 or other processing materials within each of drawers 110. Bottle inserts may be preferably configured with the retainment assembly to ensure proper processing material positioning within the processing material retainment assembly and the drawer.
Multiple drawers 104 may be included to allow for one or a plurality of sample processing protocols to be performed by the system 101. Past efforts at sample processing, as previously described, may have been limited to processing sequences for an entire batch of carriers within the system. The present invention, however, in part by providing a plurality of drawers and carrier retainment assemblies, may allow for individual, batch, or multiple batch processing, including real-time or adaptive capabilities, as further described below.
Indicator elements 112 may be provided to indicate a status of the drawers and the carriers or materials within each drawer for an operator of the system. In one embodiment, visual indicators, such as light emitting diodes in preferred embodiments, may be used to indicate if a drawer is available during operation of the sample processing system, and may indicate conditions such as a locked or open condition of a corresponding drawer, Garner capacity status of the drawer or of a carrier retainment assembly within the drawer, and chemical inventory status of the sample processing system, such as reagent loading status or capacity. A warning indication may be given by these or other indicator elements, as well as other indicative signals. One or a plurality of sensors may be utilized to determine the status of the drawer as indicated by the indicator elements 112 and to further provide processing status as further described below.
A processing material unit may be utilized to provide various processing material to the sample processing system 101 and to afford the hazardous and non-hazardous segregation of waste produced during sample processing and the avoidance of cross-contamination. In one embodiment of the present invention, the processing material unit may be configured to accommodate one or a plurality of containers such as deparaffinization solution or other material utilized in sample processing. In some embodiments, the unit may also accommodate waste containers to provide for the collection of waste material from the sample processing. Tubing or other fluid transmission elements may be connected with the containers and the sample processing system 101. Tubing or other fluid transmission elements may also be connected with the waste containers and the system 101.
In accordance with the desire for an automated processing system, embodiments of the present invention may include robotic sample process functions or a robotic motion system 172 responsive to the process operation control system 171 to achieve the desired operation steps. This may further comprise an arm 120 utilized in sample processing, potentially having robotic movement, and in some embodiments, Cartesian movement.
The arm 120 may comprise, in some preferred embodiments, one or more elements, such as an actuator probe 122, a syringe or probe 124, a sensor element and a non-discrete or other volume fluid and/or air applicator. The actuator probe may be utilized in the configuration and manipulation of the carriers in sample processing, further described below. In some preferred embodiments, the actuator probe 122 configures and manipulates the configuration of slides in the sample carrier retention devices 108 by actuation of carrier adjustment element 130 (see for example Figure 2), and in some embodiments, by contact with the slides. As mentioned, in some embodiments, manipulation or movement of the slides or the samples may be accommodated.
This movement may result in a horizontal or vertical configuration of the slides to facilitate sample processing as described below.
As mentioned above, there may be a large number of process steps accomplished.
As may also be appreciated from the nature of the processes envisioned, there may be uses of many different substances or the like. Whether involving a substance or merely a physical action, these types of items may be considered as relating to operationally-influential exteriorly-consequential information. The item may be operationally-influential in that it either its operation or failure in operation may directly or indirectly influence some type of conduct. This conduct may be exteriorly-consequential in that it may be a conduct that does not take place within the process system itself but external to it. As such the present invention may provide the capability to monitor that information.
This capability may even be considered as an operationally-influential exteriorly-consequential information monitor 402 as shown generally in Figure 10. Thus the present invention may include an ability to monitor information of a broad nature.
As but one example, the present invention may involve monitoring exteriorly-consequential information that is actually operationally-altered outside information in that S the activity conducted as part of the process system's operation actually causes a change in the information. But one example of this might be using up a particular stain substance. By monitoring this category of information, the present invention may be considered as monitoring operationally-altered outside information. This embodiment may thus be considered as including an operationally-altered outside information monitor.
Of course, these events may be influenced at least in part by at least some of the robotic sample process functions.
As previously mentioned, arm 120 may comprise syringe 124. The syringe 124 may be considered a probe in some embodiments, depending upon the requirements of protocols to be performed. Syringe 124 may be fluidically connected with and may apply one or more of the following: rinse agents, such as water; containers, potentially removably fluidically connected for the aspiration of reagents, such as aspiration of reagents from containers and to the samples presented with the carriers; and blow off or other removal agents such as an air source. Syringe 124 may be utilized to pierce processing material containers such as reagent containers. In some embodiments, a reservoir may be provided with the arm 120 to allow for various volumes to be aspirated by syringe 124. The unique configuration of the reservoir allows for efficient cleaning and drying of the internal portions of the syringe while allowing for the accurate pipetting or otherwise aspiration of a wide range of volumes.
Arm 120 may, in some preferred embodiments, comprise a sensor element. The sensor element may be used to automatically determine location and other status information of components of the sample processing system, such as reagent containers, or other processing material containers, or sample Garners. This may be used to teach the system proper and/or actual locations, and to calibrate, self calibrate, or self align the system, or the like.
In preferred embodiments, the sample processing system 101 may include an automatic slide identification element. This may be controlled to achieve the act of automatically identifying said plurality of slides. This may also be more generic such as there may be some type of sensor element and it may even comprise a reader or scanner, such as a CCD camera, utilized to determine status information of processing materials, such as reagents as well as to identify slides. The sensor element, for example, may read, detect, or otherwise determine information in the sample processing system 101, for example, from processing material containers, such as, for example, reading coded or perhaps encrypted information provided on the container to determine reagent type and reagent location within the system. The sensor element may also determine status information of sample carriers. For example, in some embodiments, slides configured with a slide retainment assembly may be provided with informational indicia, such as a code, that may indicate information about the sample presented on the slide or the processing protocol to be performed. The sensor element may read the code of the slide to determine the protocol to be performed for the particular slide and sample.
A cleaning station 140, shown in Figure l, may be included to clean elements of arm 120, and in preferred embodiments, may function to clean or otherwise remove completely the previously deposited reagent from the probe, or remove elements containing the internal and/or external surface of the probe and/or syringe 124. In one embodiment, the cleaning station may be configured to clean elements of arm 120, such as syringe 124, while such elements are configured with arm 120. The syringe may be cleaned, for example, with a water rinse through the syringe while the syringe is positioned at the cleaning station. In other embodiments of the present invention, the cleaning station 140 may be configured to allow a drop off and pick up of elements such as syringes for cleaning while allowing the processing throughput of the sample processing system to continue.
In some embodiments, multiple probes or syringes may be used to apply fluids required for the staining of histological tissues samples mounted or otherwise presented on slides. This may encompass automatic staining accomplished through a slide stain element such as the items included on the robotic motion system 172 discussed above.
The sample processing system may drop off a "dirty", contaminated, or used probe or syringe and swap it for a "clean", uncontaminated, sterilized or an unused one. One or more probes or syringes may be cleaned while the system continues processing of samples, such as applying reagent or stain with an alternate probe or syringe.

The system may access, use and wash multiple probes or syringes for pipetting or otherwise aspirating fluids required for the staining of samples mounted or otherwise presented on slides. To eliminate cross contamination, a system with a single reusable probe may wash the probe between each fluid applied. The task of washing the probe can have a large impact on the throughput of the overall system. The present invention may allow for multiple probes to be available to the system for use. The system may continuously have a clean, uncontaminated, sterilized, or an unused probe available to use and sample processing is not impacted by the required cleaning routine. The cleaning routine may be necessary to eliminate the possible cross contamination of fluids and, in some embodiments, may take up to about 1 minute to accomplish. The cumulative impact of the cleaning routine on a series of processing steps can add time to the throughput capabilities of the system. The addition of multiple probes or syringes may eliminate this impact and significantly decreases the time required to process the samples.
Embodiments of the present invention may comprise a mixing station 150, shown in Figure 1. The system may mix component fluids, such as dyes, buffers, or other processing materials, preferably on demand and as the processing steps and protocols dictate. Fluids required during the processing steps rnay sometimes need to be mixed with other fluids to create a final activated fluid mixture or cocktail.
However, the activity levels of these mixtures can be time sensitive and may therefore only be effective for a short period of time. The on demand mixing of fluids is advantageous in that it allows the fluids to be mixed immediately before being used. The syringe or probe 124, in preferred embodiments, will aspirate fluids into and from the mixing station 150 to mix component fluids. A rinse may further be dispensed into the mixing station to sterilize the station.
In preferred embodiments, slides are movable and configurable in both vertical and horizontal positions as required for the pretreatment and staining process. This allows for the automation of the pretreatment and staining of slides in various manners, including pretreatment and staining as accepted in conventional manual laboratory methods. The slides are initially loaded into the carrier retention assemblies, such as slide racks, and drawers in the horizontal position. If pretreatment is required, such as deparaffinization, the system rotates the slide into the vertical position and lowers these samples into a processing tank, further described below, filled with the required fluids. In some embodiments, the slide rack is lowered to affect lowering of the slides (see Figure 2). To perform the staining process on the slides, as described below, the System rotates or moves the slide to the horizontal position and a syringe or probe applies fluid to the sample, providing a horizontal staining of the sample. Each slide can be rotated independently allowing for the independent processing of different samples with different requirements.
The system automates, and in some embodiments mimics or otherwise corresponds to the procedure and physical attributes of the supplies used manually to perform these same pre-treatment processes. Accordingly, a processing tank may be provided. In some embodiments, components of each processing tank may be configured within a drawer 104. In some preferred embodiments, the fluids volume needed to perform pre-treatment processes are maintained but instead of the slide orientation with each other being face-to-face, as in conventional systems, they are side-to-side, although other slide configurations are not disclaimed. The processing tanks provide even distribution of fluids across the face of the slide.
In some embodiments, the processing tanks have the ability to heat and cool the slides. Heat may also be applied to each individual slide by a thermal device.
The precision and physical application of the temperature control can result in standardization and repeatability of process steps. Filling and heating tasks are performed by a computer controlled scheduler, as further described below. Fluid volume may be adjusted to account for the presence or absence of any number of slides.
In some embodiments, the individual fluids used for pretreatment may be contained in the system cabinet. Deparaffmization fluids (except DI water) may be drawn into the processing tanks, then returned to their containers for reuse.
Containers are as listed for fluids one through six. On a periodic basis, the material in the "dirty"
containers may be discarded. The "clean" containers may be moved up to the dirty position, and then fresh fluid added to clean position. DI water may be drawn from the large system DI water container, and discarded after each use. Target retrieval solution may be drawn from dedicated containers, and may be recycled or discarded after each use.
Returning to the aspect of monitoring or capturing information, an embodiment of the system may be designed to monitor replenishable supply information, such as the status of buffers, reagents, stains or the like. By monitoring for a potential need for replenishable supplies the system may not only provide the replenishable supply information monitor 403 shown in Figure 10, but it may also relieve operators of some concerns. It may also remove at least.one possibility for human error.
Significantly, the system may also act to automatically notify any number of people relative to the information monitored. With respect to replenishable supply information, the system may notify a user, an operator, an administrator, or even a supplier of an actual, potential, or impending need to replenish supplies. As such the system may be considered as including an automatic notice element 404, or an automatic operator replenishable supply notice element, an automatic supplier replenishable supply notice element, or the like.
In a similar fashion, an embodiment of the system may monitor or capture information that is of interest to the continued or continuous operation of the device. As such it may be monitoring instrument maintenance information. This may include, but is not limited to monitoring part cycle information, ranging from a gross information such ' as age of the device, estimated number of cycles, to even monitoring specific information such as monitoring individual part cycle information (e.g., how many times and actual valve was turned on or off, etc). By including an instrument maintenance monitor, an instrument maintenance information monitor 405, a part cycle monitor, or an individual part cycle monitor 406, the system may facilitate not only enhanced reliability and continuous operation, but it may permit preventative maintenance such as maintenance based on product cycles or mean times between failures. Naturally, it may also use the automatic notice element 404 such as providing an automatic maintenance notice element to inform a wide range of persons of such issues.
Of course, a large variety of information may be monitored; embodiments of the system may monitor or capture information that relates to material requirements, such as expiration dates, lot information or the like. Thus the present invention may include a material requirement information monitor 407 so that it acts to automatically monitor material requirement information. This may be a product expiration information monitor 40~ that may even act with respect to an upcoming expiration and may even cause the set of automatically advance notifying a person by providing an automatic advance expiration notice element. For items that may be very important there may even be multiple notices either concurrently or sequentially and as such the system may include a multiple advance expiration notice element. Another type of information that may be monitored is historical usage information such as information of a statistical or past nature. Thus the system may include an historical usage information monitor 409. From this, predictive estimates may even be made such as a likely date upon which to order an item or the like. Through monitoring predictive usage information, this may be one way the system may be able to provide an automatic predictive need notice element or even a predictive usage information element 410. It may also provide for a user statistical information monitor so that it can assemble and monitoring user statistical information and act on this such as by comparing to other historical or statistical information or the like. The present invention may also be configured to monitor sample process efficacy information such as by assuring particular protocols are followed or the like and may thus provide a process efficacy information monitor 411. Monitored information may be extrapolated to permit a totalizator 413 capability by adding up individual usages to know amounts left or otherwise impacted by operation. This may include totalizing usage information for an item such as a reagent or an individual part's cycles. Such a capability may serve as a totalization usage information monitor, a reagent totalizator, or a part cycle totalizator. By having a data capture element 414, the system may generate data that may include or permit analysis or use of a variety of aspects, including but not limited to: number of occurrence data, part operation data, amount of usage data, and amount of material used data. Such data may, of course, have a like element, perhaps a subroutine, to do or generate the various function or data involved.
In some embodiments, an imaging device such as an image-capture 2-D optical sensor, perhaps a CCD camera, or the like, may be used to determine the position of the sample on the slide, providing for greater accuracy during sample processing.
Embodiments of the sample processing system 101 may further provide sample diagnostic capabilities. Accordingly, in some embodiments, a device may analyze samples. A camera may be used for diagnostic purposes. In some embodiments, the sample may be scanned for further analysis, potentially by computer. The camera can also be used 1) as an area locator, 2) to locate a tissue area, 3) to apply reagent based on location and area. The scanned image may be analyzed for reagent analysis or other analyses.
The system may also generate or also monitor subject sample data. Relative to the imaging device, the system may monitor or perhaps capture image data, such a sample image data, substance image data, system image data, and even pre- and post-event image data. Each of these may be systematically stored for some purpose. Each of these may correspondingly be considered to present an appropriate element such as a system image data capture element, a substance image data capture element, a sample image data capture element, and a pre- and post-event image data capture element. In addition, there may be included a multiple image data capture element so that more than one image may exist to prove or evidence an aspect of the processing. Again, the system may act to systematically store and one or the multiple images so created. Collections of like data, such as groupings of individual sample process data, individual slide log data, and even type of protocol data may also be created.
The processing of samples may be accomplished according to some preferred embodiments as shown in Figure 4 and Figure 11 consistent with features of the present invention. Variants of these protocols and processing steps, or other processing steps, may be accomplished consistent with the present invention.
One processing sequence may broadly comprise the pre-processing of a sample, if needed, such as deparaffmization (as previously described), and further comprise target or epitope retrieval (as previously described), and sample staining.
In some embodiments, specifics of in-situ hybridization (ISH) may be addressed.
Embodiments of ISH may require a small volume of reagent, such as 15 microliters, to be placed on the sample. Heat control may be maintained between about 95-100 C
and kept constant for a period of time. Temperature may then be lowered in a controlled manner.
Furthermore, fluorescent staining or tagging in IHC or ISH (FISH) may be performed consistent with the features of the present invention.
As mentioned, the sample processing system may automate the processing of samples mounted on Garners or slides. This configuration of the system allows for the flexibility for both continuous, individual, and batch processing of slides with the design lending itself to meet established laboratory workflow demands. The multiple independent and redundant slide processing subsystems found within the system may also maintain its ability to process each slide independently.

The automatic processing may be achieved by .designing a system with automated process operation capability or sequencing through at least some steps without human intervention that may be controlled by or act in response to a process operation control system 171. This may be provided through hardware, software, or some combination of the two. One conceptual embodiment depicts some of the various capabilities in Figure
10. Of course, the user needs the ability to specify the nature and sequence of the various steps or acts desired. This can be accomplished by an input parameter capability 173 through the inclusion of even a sample process parameter input 173. This input can be retained by the creation of stored parameter process data 174. In order to facilitate uninterrupted processing, the input parameter capability 173 may be configured as an independent process parameter input with respect to the process operation control system 171, such that acts caused by the process operation control system 171 are unaffected by any action with respect to the independent process parameter input. Further, the input parameter capability 173 may also be configured as an autonomous input functionality through the inclusion of an autonomous input element.
Capabilities may not only act independent of the automated process operation capabilities, but they may be fully functional even without the presence or operability of the automated process operation capability (which itself may or may not be in a process device). This may be achieved in a variety of manners, including by providing a separate full function computer 181 (e.g., separate from the capability provided or required by a process system) or that may be programmed to accomplish the input. In addition, in order to accomplish a goal of addressing practical and institutional needs, any capability may be configured to provide simplified use and may even be available in a highly simplified level of detail. This may be a "wizard" type of system where there is a "step-by-step"
method for functions such as programming slides, adding slides, achieving the desired input, or the like. Such an aspect may even be simple, regimented, and somewhat inflexible. A structured or simplified input can facilitate input by persons not required to have the full spectrum of skills necessary to be responsible for the operation of the sample processing system 101.
As part of the functions of monitoring or perhaps allowing play back of events, the system may include some type of data capture element 414. As may be appreciated from the initial discussion of the types of actions potentially needing to be programmed, the data capture element 414 may capture individual movement data, only robotic action data, individual robotic movement data, individual operation data, or even individual usage data. Thus the data capture element 414 may be an individual movement data capture element, a robotic action data capture element, an individual robotic movement data capture element, or an individual operation data capture element. All or any part of this data may be systematically stored such as storing all important details, only particularly important details (e.g., relative to highly sensitive valves, substances, or the like) or even only a significant number of details relative to sample process operations.
'Thus the data capture element 414 may be a systematic process detail capture element.
Once captured, this data may be stored in a number of fashions. There may be a memory location at which such data resides and this may thus represent a significant process detail memory 412. It may also represent a subject sample data capture element and any of the memory types mentioned earlier may be used for such a purpose.
In storing the data, the system may create a segmented computer file, that is a file that contains only such data so that it is not as manipulatable as other files. This may aid in assuring the accuracy or even certiftability of the events depicted. For instance for any particular sample, there may be automatically generated upon request a simulation --perhaps with a time base appended -- of what happened to that particular sample as well as pictures of the sample before and after its processing. The data so stored may even be created as an inalterable computer record and perhaps may even include an integral change indicia that can prove its accuracy. When stored, the system may create a common format computer record so that user can easily work with it or it may create a proprietary format computer record that cannot be altered or the like. Thus the significant process detail memory 412 may represent a segmented computer ftle memory element, an inalterable computer record memory element, an integral change indicia memory element, a common format computer record memory element, or a proprietary format computer record memory element.
The capture of data may include time of occurrence data, such as actual date data, actual time data (e.g., UTC, etc.), precise time data (e.g., hours, minutes, seconds), relative time data, absolute time data, initiation time data, and even completion time data (e.g., process, protocol, motor operation events, or the like).
Again, the data capture element 414 may include, but is not limited to, a time of occurrence data capture element, an actual date data capture element, an actual time data capture element, a precise time data capture element, a relative time data capture element, an absolute time data capture element, an initiation time data capture element, or a completion time data capture element.
One item that may be of particular user desire is the fact that the data capture element 414 may represent an individual sample process data capture element, an individual slide log data capture element, a type of protocol data capture element, and even an individual slide log data capture element. There may also be a real time individual slide log data display to show actual processing as it occurs.
As used above, the slide identification information may represent any information unique to a particular slide, such as a serial number, patient number, patient name, unique image, or the like. In keeping with privacy concerns, there may also be coded or perhaps encrypted identification information or internal identification information that others cannot use to identify the particular patient involved or the like. As discussed below and 1 S as shown in Figures 8 & 9, the overall system may include a number of staining instruments and thus the input can include preferred stainer information (which may or may not be indicated or accepted by the automated system). Provision can also be included to achieve a rush test and as such there may be an immediate, urgent, or otherwise known as stet (an often used medical term for immediate) process request information element. Such may also be linked with user privileges information so that only certain individuals may displace other tests to create a different priority. Of course all permutations and combinations of the above may be included.
For automated operation, the input may create data such as parameter process data 174 that may be stored at some location. To provide autonomous operation, it may be independently stored perhaps in a physically independent memory even at a location remote from an actual stainer itself. This may be accomplished by utilizing a primary or secondary storage perhaps of a separate full function computer programmed or configured to accept and/or store data. In such a fashion, the computer may contain what could be considered as an independent process parameter memory 174. Since the computer is likely physically separate, it may be considered to have a physically independent memory perhaps even a remote location memory if it is remote from the process equipment.

By using independent memory and independent other functionality, the system may facilitate full operational functionality of the automated process operation capability.
Since the automated process operation capability is fully operational during operation of either the memory or input, the storing or inputting or other function can be conducted without interrupting the process operation. Thus the inputs can be later accessed at a process time independent of the time of accomplishing slide process parameter input or storing. In addition, entry or storing may also be accomplished at least in part concurrently with the processing of certain samples. This processing may even be initiated significantly after completion of the slide process parameter input action. Such may occur at least about one hour after the input, at least about three hours after the input, at least about eight hours after the input, at least about one day after the input, at least about two days after the input, and at least about one week after the input.
As mentioned briefly above, once the information is either monitored or captured, the present invention may act to automatically inform at least one person who may find the information useful. The automatic notice element 404 mentioned earlier may be configured to act as an automatic exteriorly-consequential information notice element by relating largely to that type of information. Of course, the automatic notice element 404 may act in response to the step of monitoring the particular information involved. For example, if it is monitoring operationally-altered outside information, the automatic notice element 404 may act as an automatic operationally-altered outside information notice element. For process events that are merely captured and not automatically monitored, a person may prompt the system upon which it may provide information by some type of display 415. This display (in its broadest sense) may reveal at least some information, perhaps relative to sample process operations to at least one person. If the display reveals significant process detail information, it may be considered as a significant process detail information display. Further if it displays at a separate location there may even be a significant process data transfer element to facilitate remotely displaying such information. As such the display 415 may be considered a remote process detail information display. As mentioned earlier, the system may provide for a real time information display, that is a display that reveals information at about the time it occurs. By real time displaying information remotely, the operator or any other interested person may be able to "watch" or monitor the progress of the instrument from another location -- perhaps even the other side of the world. This may be particularly valuable when there is a real time display of individual slide log data as mentioned above.

One type of display 415 that may be noteworthy is the fact that embodiments of the invention may create a simulated motion display. The simulation may visually show an element moving on a screen just as the robot head actually moved when it operated.
Embodiments can provide sequential playback capability so that one could also "watch"
the instrument just at it operated at some earlier time. There may also be an altered speed sequential playback capability, a user alterable speed sequential playback capability, or merely a high speed sequential playback capability perhaps all with or without pause or slow motion capability. With this capability, the display 415 may represent a simulated motion process detail information display. The system may thus include a sequential playback element, an altered speed sequential playback element, a user alterable speed sequential playback element, and a high speed sequential playback element.
All this information must, of course be used by some person. Any interested person may have the information available to them, such as an operator (e.g., anyone responsible for all or a portion of a process or the instrument), an instrument operator (e.g., an individual physically responsible for all or a portion of a process), an administrator (e.g., a person managing operators or perhaps responsible for order placement), a substance or other supplier, or even a manufacturer, such as for support and maintenance capability. For events that may require external actions (e.g., ordering more reagent or the like), the system may automatically notify at least one of these types of people and thus the automatic notice element 404 may be considered as representing an automatic operator notice element, an automatic administrator notice element, an automatic supplier notice element, or an automatic manufacturer notice element. It rnay also be considered as representing an automatic operator exteriorly-consequential information notice element, an automatic administrator exteriorly-consequential information notice element, an automatic supplier exteriorly-consequential information notice element, or an automatic manufacturer exteriorly-consequential information notice element.
Notice may be given at a variety of times. The system may act to automatically advance notify a person such as of an upcoming expiration date or of a need to reorder in advance. In so doing it may have or have input to it some type of lead time information that tells it how early to take the action. By properly configuring a lead time information data element 416, lead time may vary by location and situation, for example a machine around the world or used continuously for critical processing may have a longer lead time than a machine right next to a supplier or used only sporadically. Order lead time information, reagent order lead time information, maintenance lead time information (any of which may vary over the course of a year or from time to time) may be utilized and as such the lead time information data element 416 may represent an order lead time information data element, a reagent order lead time information data element, or a maintenance lead time information data element.
Notice itself may be displayed in a variety of ways. The system may automatically E-mail a person through inclusion of an E-mail notice element;
it may automatically print out (including faxing) a notice by having an automatic printout notice element. Among other possibilities, it may automatically utilize a telephone line for simulated or reproduced voice or other information by having an automatic telephone line utilization element.
The actual event of providing notice may be automatic or it may by caused by some type of user prompt 417. By accepting a monitored information user prompt the system may represent a monitored information user prompt. The prompt itself may be a mere software selection or even a mere click-on items such as a software displayed button or the like. Whether displayed and acted upon remotely or at the actual robot-containing housing, such a user prompt 417 may cause a remote access connection to be established and as a result at least some significant process data may be displayed. In such a manner the user prompt may represent an information access prompt element, a software selection element, or a remote access element.
In some embodiments, the system may be comprised of independent or perhaps redundant slide staining modules (some embodiments may comprise eight modules) as shown for some embodiments in Figures 1 and 6. Throughput may be based on the time to first result with the system allowing access to completed slides as soon as a staining module has completed the scheduled staining tasks. The multiple independent or redundant staining modules may allow for both continuous and batch processing of slides.
Additionally, each independent staining module may also allow for the independent pre-treatment and staining of each slide. A Garner retainment assembly, such as a slide retainrnent assembly, may be used to introduce slides to be processed into the drawer 104, the drawer, slide retainment assembly, and components thereof forming a stain module.

The slides may occupy one or more positions of the slide retainment assembly, such as at carrier retention devices, up to the capacity of the slide retainment assembly with the potential for each slide being processed independently of other slides configured with the slide rack. Embodiments of the stain modules, drawers, slide racks, and components thereof are also shown in Figure 6. Figure 6 also provides other embodiments of system features, such as an embodiment of the arm 120 and the component features of the arm.
Slide retainment assemblies having one or more slides and even reagent containers may be introduced into the staining or reagent modules by introduction into drawers 104 one at a time or in any combination until all or an appropriate number of staining modules are appropriately occupied. There may be no restrictions as to the order, number or timing of when the slide retainment assemblies are introduced into the system, the system may also allow for adaptive scheduling of sample loading. Staining modules, and in some embodiments the drawers of the staining modules, may lock out access to the slides during the processing period and may release them to the operator upon completion of the staining or other process on the last slide of that module. In some embodiments, the order in which the slide retainment assemblies are released may be dependant on the time required to process the last slide of the retainment, assembly. Slides may even be processed in the most time efficient manner independently of the order to which they were introduced into the system. The system may provide an optimum or merely an enhanced temporal scheduling of the various sample process steps. To accomplish this, the system may automatically schedule steps that are interspersed for an enhanced time result. This interspersing may be an interleaving of a number of process operations and even an interleaving of a number of individual sample operations. In addition to interleaving steps, the system may sequence the individual sample operations.
Regardless as to how programmed, it may be configured through hardware or software or a combination of each to provide an enhanced temporal scheduler element 179, a process operations interleave element, an individual sample operations interleave element, or even an individual sample operations sequence element. These can be created by integrating the automated process operation capability and either the parameter data or perhaps some replicated portion of that parameter process data (as mentioned later) and can thus act to create an interspersial robotic control functionality 175.

The control of the processing samples may be accomplished according to the following preferred embodiments, one preferred embodiment shown in Figure 5, although other processing may be accomplished consistent with the present invention.
As shown in Figures 8 & 9, in expanded systems, a sample processing system manager, such as a computer server may be connected with a number of individual sample processing systems. These may represent automated slide stainers or even stand alone automated slide processing system such that they are fully capable of functioning with connection to other devices. In systems where a connection does exist, the capability of electronically connecting a number of automated slide stainers or automated sample processing systems or label printers 200, may be provided. As mentioned earlier, there may be one or more separate full function computers connected. These may be connected through a hub 193. There may be a multitasked central processing unit resource on either the stainer or the computer or there may be a number of of central processing units that are configured to avoid using or implementing a multitasked central processing unit resource relative to the process operations in order to maintain full independence or perhaps even autonomous operation. The connection, whether for input or other operation may also be a remote link (including ability to be made remote such as in detachable memory) such as an Internet connection element, a telephone line connection element, a wireless communication element, or even a detachable memory element. In a preferred embodiment, connection among perhaps a number of process systems and perhaps a number of computers, such as workstations and a server (the latter residing either separately or as part of a workstation), may be achieved by use of a local area network (LAN), such as a group of computers and associated devices that share a common communications line or perhaps wireless link and may even share the resources of a single processor, memory, or server within a small geographic area (for example, within an office building or complex). A local area network for this type of system may also include features such as but not limited to: an Ethernet element, a token ring element, an arcnet element, a fiber distributed data interface element, an industry specification protocol, a bluetooth-based element (named but not contemporary to King Harald Bluetooth of Denmark in the mid-tenth century!), a telecommunications industry specification using a frequency band of 2.45 GHz, a communication speciEcation applying an IEEE 802 standard, a frequency hop communication specification, a shared common link element, a transmission control protocol/internet protocol communication element, a packetized information protocol, a shared protocol, a proprietary protocol, and even a layered protocol exchange system. By providing an electronic connection between various resources, the local area network such as the stainer network 183 (a network dedicated to only the stainer or perhaps sample processing resources for integrity, security, and other purposes) in one embodiment may transmit a electronic memory address to achieve access to the appropriate information. Connection may also be established to a lab network, facilities intranet system, or even a lab information system 195 such as through a bridge 194.
As mentioned, connection may be accomplished over Internet connections but more preferably is accomplished over local area network connections. Each sample processing system may be individually controlled, in some embodiments, by a PC
attached with, internal to, or otherwise provided. Data sharing between sample processing systems and the system manager may be performed to allow identification, tracking, and status of sample batches, reagents, and other agents and components of the sample processing system. A determination of which system has which reagents, reagent type, slides and protocols may be performed. Log files for each processing sequence, protocol, or slide can be generated for monitoring processing status. Database maintenance (including but not limited to purge, compact, back=up, databasellist functions) and system diagnostics (including but not limited to exercising active system components to verify proper operation and assisting in troubleshooting efforts) may be accomplished manually or automatically.
The system may be configured to automatically access the required data through operation of the process operation control system 171 by inclusion of an automatic memory access element. This access may be achieved by specifying an electronic memory address that may be transmitted by a electronic memory address element perhaps over a local area network and may be followed by automatically replicating that ' data on some a memory aspect appropriate for operation such as an automatic data replication memory. This memory may include but not be limited to: a volatile memory functionality as implemented by a volatile memory element, a random access memory functionality as implemented by a random access memory element, a non-volatile memory functionality as implemented by a a non-volatile memory element, an electrically erasable programmable read only memory functionality as implemented by an electrically erasable programmable read only memory element, a main storage functionality as implemented by a main storage element, a secondary storage functionality as implemented by a secondary storage element, a cache memory functionality as implemented by a cache memory element, and even a detachable memory functionality as implemented by a detachable memory element.
A control interface may be provided for the operator, such as a graphical user interface (GUI), and may accommodate various languages. Help menus may be provided to assist in sample processing. Password protection features can be provided and even administrator control over at least some aspects. 'This may include the capability to include administrator limitations on the functional availability of any aspect of the system or of specific stainer availability or functionality, certain reagent availability functionality, certain protocol availability functionality, patient identification information access functionality, process priority request functionality, and immediate, urgent, or stat process request functionality. By including an administrator control element 180, the system may have an administrator-implemented user limitation element, a speciftc stainer availability limitation element, a certain reagent availability limitation element, a certain protocol availability limitation element, a patient identification information access limitation element, a process priority request limitation element, an immediate, urgent, or perhaps stat process request limitation element, a user privileges input element, and even a user group privileges configuration or input element.
Control of the sample processing may be accomplished by a dynamic scheduling algorithm, and in some embodiments, in accordance with continuous, or batch processing previously described. The processing sequence may be controlled, in preferred embodiments, such that the various steps of a protocol for samples may be automated by one or more algorithmic controls. As part of input to establish the desired control functionality, user or other input may be accommodated as follows: 1) selecting a ftrst protocol step, 2) selecting a second protocol from a restricted list of menu items that are compatible with the ftrst protocol step, and 3) selecting subsequent protocol steps from a restricted list of menu items that are compatible with the preceding protocol step.
After all data is input, the system may act to determine operational readiness by inclusion of an operational readiness determination element 177 that may be programmed to assess if appropriate resources, drawers, slides, reagents, or other aspects are present or available to the system. Once an appropriate operational readiness is determined, the system may prompt initiation of access of the input data to electronically determine operational availability of a variety of items. These may include but are not limited to: an individual sample element through inclusion of an individual sample readiness determination element, a defined group of samples through inclusion of a defined group of samples readiness determination element, a physically grouped collection of samples through inclusion of a physically grouped collection of samples readiness determination element, a slide drawer component through inclusion of a slide drawer component readiness determination element, a stand alone automated slide processing system through inclusion of an stand alone automated slide processing system readiness determination element, a slide stainer system element through inclusion of a slide stainer system readiness determination element, and even a user initiated prompt signal such as might occur to force or activate the system manually by the inclusion of a user initiated prompt signal determination element.
There may even be timing tolerances, referred to in some embodiments as "bubble tolerance", that may be controlled as between steps, such as between aspiration cycles.
Additional control may be accomplished through timing algorithms to determine time tolerances of components of the processing system, such as the monitoring of "shelf life"
or viability of reagents. Furthermore, adaptive scheduling of sample and slide insertion and removal into the system, as previously described, may be accommodated on an on-going basis throughout operation of the sample processing system.
One aspect of the invention focuses on an automated staining apparatus and a method of automated treating of samples. As to this aspect, the present invention relates to an automated staining apparatus for treating samples arranged on carrier elements or means, such as but not limited to microscope slides, located at defined positions close to or in the apparatus by removing a portion of selected reagent from a station containing a plurality of reagents and thereafter applying the reagent to a sample, e.g. a tissue, organic cells, bacteria etc., arranged on the carrier means. This aspect of the invention facilitates that two or more reagents are mixed and the mixture applied to a sample. It also relates to a method of automated treating of samples by mixing reagents and applying the mixture to the samples.
Staining apparatuses for staining and treating samples by means of a probe normally comprises a first station for containing one or more reagent vials; a second station for mounting slides, a probe arranged for removing a portion of reagent from a selected reagent vial and applying the reagent to a slide on which the sample is arranged and a drive means for moving the probe between the various stations.
An object of this aspect of the present invention is to improve the known apparatuses for staining samples as well as the method for automatic staining of samples by facilitating a wider range of available processes or procedures used to implement treatment, so as to ease the implementation of different staining and/or treatment processes that may be performed automatically, alternatively or additionally to provide an increased quality of some specific staining processes.
The term staining is used for the end product of the process, by which certain parts of the sample may be stained, i.e. has obtained a different colour, either in the optic range or in another electromagnetic range, such as ultra violet, or the staining may be an detectable, preferably automatically detectable, change in properties, such as fluorescent properties, magnetic properties, electrical properties or radioactive properties. To obtain the staining, the sample normally has to undergo a series of treatment steps, such as washing, binding of reagents to the specific parts of the sample, activation of the reagents, etc. and each treatment step may include a plurality of individual treatments.
In some staining processes, it may be required for one or more treatments to use a mixture of reagents prepared from two or more separate reagents which may be somewhat incompatible e.g. unmixable, such as a water based and an oil based reagent, or insoluble, and therefore requires that the two or more reagents are manually prepared and introduced into a reagent vial shortly before starting the staining process in order to obtain the best possible staining result for the selected examination purposes. For other processes, different staining process steps require a mixture of the same two reagents but in different dissolved ratios. Some process steps require mixtures of two or more reagents that, when mixed, have a limited time window of usability because internal chemical processes deteriorate the mixture. By providing a staining apparatus having an automated mixer integrated therein, these types of staining processes can be performed automatically instead of requiring human interaction or manual performance of some process steps in a much more automated process, and the quality of the staining process may be improved as a desired degree of mixing of reagents may be provided or an optimal application time window for a deteriorating mixture may be reached.

The carrier elements or perhaps means are preferably arranged in groups or series on trays or the like, so that a plurality of carrier means may be removed from or situated in the apparatus simultaneously, and the apparatus preferably also comprises means for performing the intermediate storage of the Garner means with samples thereon and the removal of the carrier means from the apparatus automatically.
The operation of the staining apparatus may generally be controlled by means of a control element or perhaps a control means, typically a computer having a central processing unit and one or more memory units associated therewith, an control element or perhaps a means for controlling the various operations of the apparatus by controlling stepper motors, solenoids, valves anrllor other drive or control parts of the apparatus. The control means may have one or more data communication ports for enabling data communication with external computers by wire or wireless. The control means does not have to be physically arranged within the apparatus itself but may be a computer external to the staining apparatus and connected to the apparatus via a data transmission port thereof.
The operation of the staining apparatus will generally be controlled by means of control means, typically a computer having a central processing unit and one or more memory unit associated therewith, means for controlling the various operations of the apparatus by controlling stepper motors, solenoids, valves and/or other drive or control parts of the apparatus. The control means may have one or more data communication ports for enabling data communication with external computers by wire or wireless elements. The control element or perhaps means does not have to be physically arranged within the apparatus itself but may be a computer external to the staining apparatus and connected to the apparatus via a data transmission port thereof.
The present invention also relates to a method of fully automated treating of samples arranged on carrier elements by means of a staining apparatus controlled by means of a control element or means, wherein the method comprises the steps of situating a plurality of Garner means intermediately in a Garner means station, each Garner means having a sample arranged thereon, applying a portion of a first reagent selected from a plurality of reagents to a mixing cup, applying a portion of a second reagent selected from a plurality of reagents to the mixing cup, mixing the reagents in the mixing cup by means of mixing means, moving a probe to the mixing cup by means of a probe drive means, removing a portion of the mixed reagents from the mixing cup by means of the probe, moving the probe to a selected one of said carrier means, and applying the mixed reagents to the selected Garner means, so as to perform a treatment of the sample arranged on the selected Garner means.
The present invention further relates to the use of an apparatus of the present invention as described above for exercising the method of the present invention.
The embodiment shown in the figures and described in details below is only an example of an apparatus in accordance with the present invention and is not limiting the wider scope of the invention as described in the enclosed claims.
As shown in figure 6, a detailed description of one embodiment of this aspect of the invention involves staining apparatus 201. The staining apparatus 201 may comprise a rectangular frame 204 surrounding a first station 202 comprising an array of compartments wherein each compartment a reagent vial 203 is placed, and a second station 205 wherein a number of separate racks 206 is placed, and where each rack may comprise a number of slides 207 mounted side by side in the rack 206. In the embodiment shown, each rack may hold up to 17 slides, but the rack may be designed to hold any suitable number of slides. With eight racks arranged side by side, the shown embodiments rnay hold up to 136 slides 207 each having a sample, e.g. a tissue mounted on the upper side of the slide, so that reagent may be applied from above to the sample on each slide.
A robot arm to move a probe 210 in X and Y direction as indicated by the arrows X and Y may be arranged above the frame 204 of the staining apparatus. The robot arm rnay therefore position the probe 210 above all reagent containers 203 as well as above all the slides 207, and may further operate the probe 210 to remove portions of a reagent contained in any of the containers 203, to transfer the portion of reagent and apply it to any of the slides 207 in order to provide a selected staining or treatment of the sample on each slide 207. By use of a suitable control element, e.g. a computer having the appropriate software, subroutines, or input data for the purpose, this staining apparatus 201 may be able to automatically stain or treat samples requiring different staining or treatment reagents and processes.

Having the appropriate input data, the control element or perhaps means of the apparatus may operate the robot arm to commence a staining or treatment run by moving the probe to a ftrst reagent container 203, into which the probe tip is inserted and liquid is aspirated up into the probe 210 in an amount corresponding to the number of samples to be stained or treated, in accordance with the input data provided to the control element.
Additionally, under certain conditions, the instrument may be required to perform a reagent inventory before a staining or treatment run can commence. This inventory may be accomplished by use of the probe tip to actually touch the liquid surface in each reagent vial 203. To prevent cross-contamination between the reagents in the various containers 203, a cleaning of the probe 210 or at least the probe tip may be required after each measurement of a reagent level.
The probe 210 may be moved by the robot arm towards the slide retainment assembly 205 in which the slides 207 are mounted. The slides 207 may be situated with the surface horizontally oriented and the probe 124 may dispense the required amount of reagent on the appropriate slides in accordance with the input data.
Alternatively, the probe 124 may be moved by the robot arm towards the reagent mixer 209 where it may release reagent into the cup of the reagent mixer 209, and may be subsequently moved to the probe washing station 208. The robot arm may move the new clean probe to a second selected reagent vial 203 for collecting a selected amount of reagent from the second vial 203, and the probe may thereafter by means of the robot arm be moved to the reagent mixer 209, where the reagent in the probe 210 may be released into the cup of the mixer containing the first selected reagent. This may be commenced several times if more than two reagents are to be mixed for a specific staining or treatment process.
An object of the present invention is to provide a staining apparatus and a method for automatic staining of samples, in which the total process time for completing or even entering the staining protocol may be reduced. In particular, it is an object of this aspect of the invention to reduce the amount of time needed in general.
As can be easily understood from the foregoing, the basic concepts of the present invention may be embodied in a variety of ways. It involves both sample processing techniques as well as various systems, assemblies, and devices to accomplish sample processing, input, and other functions. In this application, the sample processing techniques are also disclosed as part of the results shown to be achieved by the various systems, assemblies, and devices described and as steps which are inherent to utilization.
They should be understood to be the natural result of utilizing the devices as intended and described. In addition, while some devices are disclosed, it should be understood that these not only accomplish certain methods but also can be varied in a number of ways.
Importantly, as to all of the foregoing, all of these facets should be understood to be encompassed by this disclosure.
The discussion included in this application is intended to serve as a basic description. The reader should be aware that the specific discussion may not explicitly describe all embodiments possible; many alternatives are implicit. It also may not fully explain the generic nature of the invention and may not explicitly show how each feature or element can actually be representative of a broader function or of a great variety of alternative or equivalent elements. Again, these are implicitly included in this disclosure.
Where the invention is described in device-oriented terminology, each element of the device implicitly performs a function. Importantly, neither the description nor the terminology is intended to limit the scope of the claims which may be included at any ' time.
It should also be understood that a variety of changes may be made without departing from the essence of the invention. Such changes are also implicitly included in the description. They still fall within the scope of this invention. A broad disclosure encompassing both the explicit embodiments) shown, the great variety of implicit alternative embodiments, and the broad methods or processes and the like are encompassed by this disclosure and may be relied upon at any time.
Further, each of the various elements of the invention and claims may also be achieved in a variety of manners. This disclosure should be understood to encompass ' each such variation, be it a variation of an embodiment of any apparatus embodiment, a method or process embodiment, or even merely a variation of any element of these.
Particularly, it should be understood that as the disclosure relates to elements of the invention, the words for each element may be expressed by equivalent apparatus terms or method terms -- even if only the function or result is the same. Such equivalent, broader, or even more generic terms should be considered to be encompassed in the description of each element or action. Such terms can be substituted where desired to make explicit the implicitly broad coverage to which this invention is entitled. As but one example, it should be understood that all actions may be expressed as a means for taleing that action or as an element which causes that action. Similarly, each physical element disclosed should be understood to encompass a disclosure of the action which that physical element facilitates. Regarding this last aspect, as but one example, the disclosure of a "retention element" should be understood to encompass disclosure of the act of "retaining" --whether explicitly discussed or not -- and, conversely, were there effectively disclosure of the act of "retaining", such a disclosure should be understood to encompass disclosure of a "retention element" and even a "means for retaining". It should also be understood that in jurisdictions where specific language may be construed as limiting, as but one example in the United States where some interpretations of "means for" elements can be construed narrowly, broader equivalent language may be used and should be understood as encompassed by this specification. Such changes and alternative terms are to be understood to be explicitly included in the description.
Any patents, patent applications, publications, or other references mentioned in this application for patent are hereby incorporated by reference. In addition, as to each term used it should be understood that unless its utilization in this application is inconsistent with such interpretation, common dictionary definitions should be understood as incorporated for each term and all definitions, alternative terms, and synonyms such as contained in the Random House Webster',,s Unabridged Dictionary, second edition are hereby incorporated by reference as well as the definitions presented by searchStorage.com, such to be considered as representing the meaning of the terms as understood by computer professionals. Finally, any priority case for this application is hereby appended and hereby incorporated by reference.
Thus, the applicants) should be understood to have support to claim at least:
i) each of the sample processing systems and subsystems as herein disclosed and described, ii) the related methods disclosed and described, iii) similar, equivalent, and even implicit variations of each of these systems, assemblies, devices and methods, iv) those alternative designs which accomplish each of the functions shown as are disclosed and described, v) those alternative designs and methods which accomplish each of the functions shown as are implicit to accomplish that which is disclosed and described, vi) each feature, component, and step shown as separate and independent inventions, vii) the applications enhanced by the various systems or components disclosed, viii) the resulting products produced by such systems or components, and ix) methods and systems, assemblies, devices, and apparatuses substantially as described hereinbefore and with reference to any of the accompanying examples, x) the various combinations and permutations of each of the elements disclosed, xi) each potentially dependent claim or concept as a dependency on each and every one of the independent claims or concepts presented, xii) processes performed with the aid of or on a computer as described throughout the above discussion, xiii) a programmable system as described throughout the above discussion, xiv) a computer readable memory encoded with data to direct a computer comprising means or elements which function as described throughout the above discussion, xv) a computer configured as herein disclosed and described, xvi) individual or combined subroutines and programs as herein disclosed and described, xvii) the related methods disclosed and described, xviii) similar, equivalent, and even implicit variations of each of these systems and methods, xix) those alternative designs which accomplish each of the functions shown as are disclosed and described, xx) those alternative designs and methods which accomplish each of the functions shown as are implicit to accomplish that which is disclosed and described, xxi) each feature, component, and step shown as separate and independent inventions, and xxii) the various combinations and permutations of each of the above.
Further, if or when used, the use of the transitional phrase "comprising" or the like is used to maintain the "open-end" claims herein, according to traditional claim interpretation. Thus, unless the context requires otherwise, it should be understood that the term "comprise" or variations such as "comprises" or "comprising" or the like, are intended to imply the inclusion of a stated element or step or group of elements or steps but not the exclusion of any other element or step or group of elements or steps. Such terms should be interpreted in their most expansive form so as to afford the applicant the broadest coverage legally permissible.
Any claims set forth at any time are hereby incorporated by reference as part of this description of the invention, and the applicant expressly reserves the right to use all of or a portion of such incorporated content of such claims as additional description to support any of or all of the claims or any element or component thereof, and the applicant further expressly reserves the right to move any portion of or all of the incorporated content of such claims or any element or component thereof from the description into the claims or vice-versa as necessary to define the matter for which protection is sought by this application or by any subsequent continuation, division, or continuation-in-part application thereof, or to obtain any benefit of, reduction in fees pursuant to, or to comply with the patent laws, rules, or regulations of any country or treaty, and such content incorporated by reference shall survive during the entire pendency of this application including any subsequent continuation, division, or continuation-in-part application thereof or any reissue or extension thereon.

Claims (158)

What is claimed is:
1. A method of automated sample processing comprising the steps of:
establishing an automated sample processing system having an automated process operation capability that causes automated process operation events through robotic sample process functions;
monitoring operationally-influential exteriorly-consequential information;
automatically processing at least one sample at least in part through operation of said robotic sample process functions; and automatically informing at least one person of at least some exteriorly-consequential information in response to said step of monitoring operationally-influential exteriorly-consequential information.
2. A method of automated sample processing as described in claim 1 wherein said step of establishing an automated sample processing system having an automated process operation capability that causes automated process operation events through robotic sample process functions comprises the step of establishing an automated slide processing system.
3. A method of automated sample processing as described in claim 2 wherein said step of automatically processing at least one sample comprises the steps of arranging a plurality of slides on a carrier retainment assembly;
applying a reagent to said plurality of slides; and automatically staining said plurality of slides.
4. A method of automated sample processing as described in claim 3 wherein said step of establishing an automated sample processing system having an automated process operation capability that causes automated process operation events through robotic sample process functions comprises the steps of:
establishing a plurality of automated slide stainers; and electronically connecting said plurality of automated slide stainers.
5. A method of automated sample processing as described in claim 1 , 3, or 4 and further comprising the step of establishing a local area network electronically connected to said automated sample processing system.
6. A method of automated sample processing as described in claim 3 or 4 and further comprising the step of holding said plurality of slides on at least one movable carrier retainment assembly.
7. A method of automated sample processing as described in claim 1 wherein said step of monitoring operationally-influential exteriorly-consequential information comprises the step of monitoring operationally-altered outside information concerning events influenced at least in part by at least some of said robotic sample process functions; and wherein said step of automatically informing at least one person of at least some exteriorly-consequential information comprises the step of automatically informing at least one person of said operationally-altered outside information.
8. A method of automated sample processing as described in claim 1 wherein said step of monitoring operationally-influential exteriorly-consequential information comprises the step of monitoring replenishable supply information.
9. A method of automated sample processing as described in claim 8 and further comprising the step of automatically notifying at least one operator of a potential need for replenishable supplies in response to said step of monitoring operationally-altered outside information concerning events.
10. A method of automated sample processing as described in claim 8 and further comprising the step of automatically notifying at least one supplier of a potential need for replenishable supplies in response to said step of monitoring operationally-altered outside information concerning events.
11. A method of automated sample processing as described in claim 1 wherein said step of monitoring operationally-influential exteriorly-consequential information comprises the step of monitoring instrument maintenance information.
12. A method of automated sample processing as described in claim 11 and further comprising the step of automatically notifying at least one operator of a potential need for maintenance in response to said step of monitoring instrument maintenance information.
13. A method of automated sample processing as described in claim 11 wherein said step of monitoring instrument maintenance information comprises the step of monitoring part cycle information.
14. A method of automated sample processing as described in claim 13 wherein said step of monitoring part cycle information comprises the step of monitoring individual part cycle information.
15. A method of automated sample processing as described in claim 1 or 13 and further comprising the step of automatically notifying at least one supplier of a potential need for maintenance in response to said step of monitoring operationally-influential exteriorly-consequential information.
16. A method of automated sample processing as described in claim 1 wherein said step of monitoring operationally-influential exteriorly-consequential information comprises the step of monitoring product expiration information.
17. A method of automated sample processing as described in claim 16 and further comprising the step of automatically advance notifying at least one person of an upcoming expiration in response to said step of monitoring product expiration information.
18. A method of automated sample processing as described in claim 16 wherein said step of automatically advance notifying at least one person of an upcoming expiration comprises the step of accomplishing multiple notifications of an upcoming expiration.
19. A method of automated sample processing as described in claim 17 wherein said step of automatically advance notifying at least one person of an upcoming expiration in response to said step of monitoring operationally-altered outside information concerning events comprises the step of automatically advance notifying a person selected from a group consisting of:
an instrument operator, an administrator, and a supplier.
20. A method of automated sample processing as described in claim 1 and further comprising the step of monitoring historical usage information.
21. A method of automated sample processing as described in claim 20 wherein said step of monitoring historical usage information comprises the step of monitoring user statistical information.
22. A method of automated sample processing as described in claim 20 and further comprising the step of automatically advance notifying at least one person of a predictive need in response to said step of monitoring historical usage information.
23. A method of automated sample processing as described in claim 22 wherein said step of automatically advance notifying comprises the step of automatically advance notifying an instrument operator of information at least in part in response to said step of monitoring historical usage information.
24. A method of automated sample processing as described in claim 1 , 20, 22, or 23 and further comprising the step of accepting a monitored information user prompt.
25. A method of automated sample processing as described in claim 24 wherein said step of automatically informing at least one person of at least some exteriorly-consequential information acts in response to said step of accepting a monitored information user prompt.
26. A method of automated sample processing as described in claim 1 wherein said step of monitoring operationally-influential exteriorly-consequential information comprises the step of totalizing usage information for an item.
27. A method of automated sample processing as described in claim 26 wherein said step of totalizing usage information for an item comprises the step of totalizing reagent usage information.
28. A method of automated sample processing as described in claim 26 wherein said step of totalizing usage information for an item comprises the step of totalizing individual part cycle information.
29. A method of automated sample processing as described in claim 1 wherein said step of monitoring operationally-influential exteriorly-consequential information comprises the step of monitoring predictive usage information.
30. A method of automated sample processing as described in claim 29 wherein said step of monitoring predictive usage information comprises the step of utilizing order lead time information.
31. A method of automated sample processing as described in claim 29 wherein said step of monitoring predictive usage information comprises the step of utilizing reagent order lead time information
32. A method of automated sample processing as described in claim 29 wherein said step of monitoring predictive usage information comprises the step of utilizing maintenance lead time information.
33. A method of automated sample processing as described in claim 1 wherein said step of automatically informing at least one person of at least some exteriorly-consequential information comprises the step of automatically informing at least one operator of at least some exteriorly-consequential information.
34. A method of automated sample processing as described in claim 1 wherein said step of automatically informing at least one person of at least some exteriorly-consequential information comprises the step of automatically informing at least one administrator of at least some exteriorly-consequential information.
35. A method of automated sample processing as described in claim 1 wherein said step of automatically informing at least one person of at least some exteriorly-consequential information comprises the step of automatically informing at least one supplier of at least some exteriorly-consequential information.
36. A method of automated sample processing as described in claim 1 wherein said step of automatically informing at least one person of at least some exteriorly-consequential information comprises the step of automatically informing at least one manufacturer of at least some exteriorly-consequential information.
37. A method of automated sample processing as described in claim 1 wherein said step of automatically informing at least one person of at least some exteriorly-consequential information comprises the step of automatically E-mailing at least one person of at least some exteriorly-consequential information.
38. A method of automated sample processing as described in claim 1 wherein said step of automatically informing at least one person of at least some exteriorly-consequential information comprises the step of automatically printing out at least some exteriorly-consequential information.
39. A method of automated sample processing as described in claim 1 wherein said step of automatically informing at least one person of at least some exteriorly-consequential information comprises the step of automatically utilizing a telephone line.
40. A method of automated sample processing as described in claim 1 wherein said step of monitoring operationally-influential exteriorly-consequential information comprises the step of monitoring sample process efficacy information.
41. A method of automated sample processing as described in claim 40 wherein said step of monitoring sample process efficacy information comprises the step of monitoring material requirement information.
42. A method of automated sample processing as described in claim 1 wherein said step of monitoring operationally-influential exteriorly-consequential information comprises the step of monitoring any of the permutations and combinations of information selected from a group consisting of:
replenishable supply information, instrument maintenance information, product expiration information, historical usage information, totalization usage information, predictive usage information, and process efficacy information.
43. An automated sample processing system comprising:
at least one sample arranged on a carrier element;
a process operation control system configured to at least partially process said sample;
robotic motion system responsive to said process operation control system;
an operationally-influential exteriorly-consequential information monitor; and an automatic exteriorly-consequential information notice element responsive to said operationally-influential exteriorly-consequential information monitor.
44. An automated sample processing system as described in claim 43 wherein said at least one sample arranged on a carrier element comprises a biological sample arranged on a slide.
45. An automated sample processing system as described in claim 44 wherein said process operation control system configured to at least partially process said sample comprises:
a plurality of slides on a carrier element retainment assembly;
at least one reagent container; and a slide stain element configured to act upon said plurality of slides.
46. An automated sample processing system as described in claim 45 and further comprising:
a plurality of automated slide stainers; and an electronic connection to said plurality of automated slide stainers.
47. An automated sample processing system as described in claim 43, 45, or 46 and further comprising a local area network electronically connected to a stand alone automated slide processing system.
48. An automated sample processing system as described in claim 45 or 46 wherein said carrier element comprises a movable carrier element.
49. An automated sample processing system as described in claim 43 wherein said operationally-influential exteriorly-consequential information monitor comprises an operationally-altered outside information monitor, and wherein said automatic exteriorly-consequential information notice element comprises an automatic operationally-altered outside information notice element.
50. An automated sample processing system as described in claim 43 wherein said operationally-altered outside information monitor comprises a replenishable supply information monitor.
51. An automated sample processing system as described in claim 50 and further comprising an automatic operator replenishable supply notice element that acts in response to said replenishable supply information monitor.
52. An automated sample processing system as described in claim 50 and further comprising an automatic supplier replenishable supply notice element that acts in response to said replenishable supply information monitor.
53. An automated sample processing system as described in claim 43 wherein said operationally-influential exteriorly-consequential information monitor comprises an instrument maintenance monitor.
54. An automated sample processing system as described in claim 53 and further comprising an automatic operator notice element that acts in response to said instrument maintenance information monitor.
55. An automated sample processing system as described in claim 53 wherein said instrument maintenance monitor comprises a part cycle monitor.
56. An automated sample processing system as described in claim 55 wherein said part cycle monitor comprises an individual part cycle monitor.
57. An automated sample processing system as described in claim 43 or 55 and further comprising an automatic maintenance notice element that acts in response to said operationally-influential exteriorly-consequential information monitor.
58. An automated sample processing system as described in claim 43 wherein said operationally-influential exteriorly-consequential information monitor comprises a product expiration information monitor.
59. An automated sample processing system as described in claim 58 and further comprising an automatic advance expiration notice element that acts in response to said product expiration information monitor.
60. An automated sample processing system as described in claim 59 wherein said automatic advance expiration notice element comprises a multiple advance expiration notice element.
61. An automated sample processing system as described in claim 59 wherein said automatic advance expiration notice element comprises a notice element selected from a group consisting of:
an instrument operator notice element, an administrator notice element, and a supplier notice element.
62. An automated sample processing system as described in claim 43 and further comprising a historical usage information monitor.
63. An automated sample processing system as described in claim 62 wherein said historical usage information monitor comprises a user statistical information monitor.
64. An automated sample processing system as described in claim 62 and further comprising an automatic predictive need notice element that acts in response to said historical usage information monitor.
65. An automated sample processing system as described in claim 64 wherein said automatic predictive need notice element comprises an automatic operator notice element.
66. An automated sample processing system as described in claim 43, 62, 64, or and further comprising a monitored information user prompt.
67. An automated sample processing system as described in claim 66 wherein said automatic exteriorly-consequential information notice element acts in response to said monitored information user prompt.
68. An automated sample processing system as described in claim 43 wherein said operationally-influential exteriorly-consequential information monitor comprises a totalizator.
69. An automated sample processing system as described in claim 68 wherein said totalizator comprises a reagent totalizator.
70. An automated sample processing system as described in claim 68 wherein said totalizator comprises a part cycle totalizator.
71. An automated sample processing system as described in claim 43 wherein said operationally-influential exteriorly-consequential information monitor comprises a predictive usage information element.
72. An automated sample processing system as described in claim 71 wherein said predictive usage information element comprises' an order lead time information data element.
73. An automated sample processing system as described in claim 71 wherein said predictive usage information element comprises a reagent order lead time information data element.
74. ~An automated sample processing system as described in claim 71 wherein said predictive usage information element comprises a maintenance lead time information data element.
75. ~An automated sample processing system as described in claim 43 wherein said automatic exteriorly-consequential information notice element comprises an automatic operator exteriorly-consequential information notice element.
76. ~An automated sample processing system as described in claim 43 wherein said automatic exteriorly-consequential information notice element comprises an automatic administrator exteriorly-consequential information notice element.
77. ~An automated sample processing system as described in claim 43 wherein said automatic exteriorly-consequential information notice element comprises an automatic supplier exteriorly-consequential information notice element.
78. ~An automated sample processing system as described in claim 43 wherein said automatic exteriorly-consequential information notice element comprises an automatic manufacturer exteriorly-consequential information notice element.
79. ~An automated sample processing system as described in claim 43 wherein said automatic exteriorly-consequential information notice element comprises an~
automatic E-mail notice element.
80. ~An automated sample processing system as described in claim 43 wherein said automatic exteriorly-consequential information notice element comprises an automatic printout notice element.
81. ~An automated sample processing system as described in claim 43 wherein said automatic exteriorly-consequential information notice element comprises an automatic telephone line utilization element.
82. ~An automated sample processing system as described in claim 43 wherein said operationally-influential exteriorly-consequential information monitor comprises a sample process efficacy information monitor.
83. ~An automated sample processing system as described in claim 82 wherein said~
sample process efficacy information monitor comprises a material requirement information monitor.
84. ~An automated sample processing system as described in claim 43 wherein said operationally-influential exteriorly-consequential information monitor comprises any of the permutations and combinations of a monitor selected from a group~
consisting of:
replenishable supply information monitor, instrument maintenance information monitor, product expiration information monitor, historical usage information monitor, totalization usage information monitor, predictive usage information monitor, and process efficacy information monitor.
85. ~A method of automated sample processing comprising the steps of:
establishing an automated sample processing system having an automated process operation capability that causes automated process operation events through robotic sample process functions;
scheduling a plurality of sample process operations;
systematically storing important details of a significant number of said plurality of sample process operations as such sample process operations occur;
automatically processing at least one sample at least in part through operation of said robotic sample process functions sequencing through said scheduled plurality of sample process operations; and accepting a prompt from a user to display at least a portion of said important details of a significant number of said plurality of sample process operations; and providing information relative to said plurality of sample process operations to at least one person.
86. ~A method of automated sample processing as described in claim 85 wherein said step of establishing an automated sample processing system having an automated process operation capability that causes automated process operation events through robotic sample process functions comprises the step of establishing an automated slide processing system.
87. A method of automated sample processing as described in claim 86 wherein said step of automatically processing at least one sample comprises the steps of:
arranging a plurality of slides on a carrier retainment assembly;
applying a reagent to said plurality of slides; and automatically staining said plurality of slides.
88. A method of automated sample processing as described in claim 87 wherein said step of establishing an automated sample processing system having an automated process operation capability that causes automated process operation events through robotic sample process functions comprises the steps of:
establishing a plurality of automated slide stainers; and electronically connecting said plurality of automated slide stainers.
89. A method of automated sample processing as described in claim 85, 87, or 88 and further comprising the step of establishing a local area network electronically connected to said automated sample processing system.
90. A method of automated sample processing as described in claim 87 or 88 and further comprising the step of holding said plurality of slides on at least one movable carrier retainment assembly.
91. A method of automated sample processing as described in claim 87 wherein said step of systematically storing important details of a significant number of said plurality of sample process operations as such sample process operations occur comprises the steps of:
systematically storing time of occurrence data, systematically storing substance identifier data, systematically storing individual robotic movement data, systematically storing subject sample data, and systematically storing type of protocol data.
92. A method of automated sample processing as described in claim 85 wherein said step of systematically storing important details of a significant number of said plurality of sample process operations as such sample process operations occur comprises the step of systematically storing details selected from a group consisting of:
time of occurrence data, number of occurrence data, part operation data, amount of usage data, amount of material used data, type of material used data, substance identifier data, individual movement data, robotic action data, individual robotic movement data, individual operation data, individual usage data, actual date data, actual time data, precise time data, relative time data, absolute time data, initiation time data, completion time data, subject sample data, sample image data, individual sample process data, individual slide log data, system image data, substance image data, and type of protocol data.
93. A method of automated sample processing as described in claim 85 wherein said step of systematically storing important details of a significant number of said plurality of sample process operations as such sample process operations occur comprises the step of systematically storing amount of material used data.
94. A method of automated sample processing as described in claim 92 wherein said step of systematically storing important details of a significant number of said plurality of sample process operations as such sample process operations occur comprises the step of systematically storing robotic action data.
95. A method of automated sample processing as described in claim 94 wherein said step of systematically storing important details of a significant number of said plurality of sample process operations as such sample process operations occur comprises the step of systematically storing individual robotic movement data.
96. A method of automated sample processing as described in claim 85 wherein said step of systematically storing important details of a significant number of said plurality of sample process operations as such sample process operations occur comprises the step of systematically storing precise time data.
97. A method of automated sample processing as described in claim 96 wherein said step of systematically storing important details of a significant number of said plurality of sample process operations as such sample process operations occur comprises the step of systematically storing relative time data.
98. A method of automated sample processing as described in claim 96 wherein said step of systematically storing important details of a significant number of said plurality of sample process operations as such sample process operations occur comprises the step of systematically storing absolute time data.
99. A method of automated sample processing as described in claim 85 wherein said step of systematically storing important details of a significant number of said plurality of sample process operations as such sample process operations occur comprises the step of systematically storing image data.
100. A method of automated sample processing as described in claim 99 wherein said step of systematically storing image data comprises the step of systematically storing sample image data.
101. A method of automated sample processing as described in claim 99 wherein said step of systematically storing image data comprises the step of systematically storing substance image data.
102. A method of automated sample processing as described in claim 99 wherein said step of systematically storing image data comprises the step of systematically storing system image data.
103. A method of automated sample processing as described in claim 99, 100, 101, 102 wherein said step of systematically storing image data comprises the step of systematically storing multiple image data.
104. A method of automated sample processing as described in claim 103 wherein said step of systematically storing multiple image data comprises the step of systematically storing pre- and post-event image data.
105. A method of automated sample processing as described in claim 85 wherein said step of systematically storing important details of a significant number of said plurality of sample process operations as such sample process operations occur comprises the step of creating a segmented computer file.
106. ~A method of automated sample processing as described in claim 85 wherein said step of systematically storing important details of a significant number of said plurality of sample process operations as such sample process operations occur comprises the step of creating an inalterable computer record.
107. ~A method of automated sample processing as described in claim 106 wherein said step of creating an inalterable computer record comprises the step of creating integral change indicia as part of said inalterable computer record.
108. ~A method of automated sample processing as described in claim 85 wherein said step of systematically storing important details of a significant number of said plurality of sample process operations as such sample process operations occur comprises the step of creating a common format computer record.
109. ~A method of automated sample processing as described in claim 85 wherein said step of systematically storing important details of a significant number of said plurality of sample process operations as such sample process operations occur comprises the step of creating a proprietary format computer record.
110. ~A method of automated sample processing as described in claim 85 wherein said step of accepting a prompt from a user to display at least a portion of said important details of a significant number of said plurality of sample process operations comprises the step of providing a software selection to a user.
111. ~A method of automated sample processing as described in claim 85 wherein said step of accepting a prompt from a user to display at least a portion of said important details of a significant number of said plurality of sample process operations comprises the step of utilizing a remote access connection.
112. ~A method of automated sample processing as described in claim 85 wherein said step of providing information relative to said plurality of sample process operations to at least one person comprises the step of displaying at least a portion of said information.
113. A method of automated sample processing as described in claim 112 wherein said step of displaying at least a portion of said information comprises the step of remotely displaying at least a portion of said information.
114. ~A method of automated sample processing as described in claim 85 or 112 wherein said step of displaying at least a portion of said information comprises the step of real time displaying at least a portion of said information.
115. ~A method of automated sample processing as described in claim 112 wherein said step of displaying at least a portion of said information comprises the step of creating a simulated motion display from at least a portion of said information.
116. ~A method of automated sample processing as described in claim 85 wherein said step of providing information relative to said plurality of sample process operations to at least one person comprises the step of providing a sequential playback capability.
117. ~A method of automated sample processing as described in claim 116 wherein said step of providing a sequential playback capability comprises the step of providing an altered speed sequential playback capability.
118. ~A method of automated sample processing as described in claim 117 wherein said step of providing an altered speed sequential playback capability comprises the step of providing a user alterable speed sequential playback capability.
119. ~A method of automated sample processing as described in claim 117 wherein said step of providing an altered speed sequential playback capability comprises the step of providing a high speed sequential playback capability.
120. A method of automated sample processing as described in claim 85 wherein said step of systematically storing important details of a significant number of said plurality of sample process operations as such sample process operations occur comprises the step of systematically storing individual slide log data.
121. ~A method of automated sample processing as described in claim 85 and further comprising the step of real time displaying individual slide log data.
122. ~An automated sample processing system comprising:
at least one sample arranged on a carrier element;
a process operation control system configured to at least partially process said sample;
robotic motion system responsive to said process operation control system;
a multiple event scheduler to which said robotic motion system is at least in part responsive;
systematic process detail capture element;
a significant process detail memory responsive to said systematic process detail capture element and that stores at least some significant process data;
an information access prompt element to which said significant process data is responsive; and a significant process data transfer element.
123. An automated sample processing system as described in claim 122 wherein said at least one sample arranged on a Garner element comprises a biological sample arranged on a slide.
124. An automated sample processing system as described in claim 123 wherein said process operation control system configured to at least partially process said sample comprises:
a plurality of slides on a carrier element retainment assembly;
at least one reagent container; and a slide stain element configured to act upon said plurality of slides.
125. ~An automated sample processing system as described in claim 124 and further comprising:
a plurality of automated slide stainers; and an electronic connection to said plurality of automated slide stainers.
126. ~An automated sample processing system as described in claim 122, 124, or and further comprising a local area network electronically connected to a stand alone automated slide processing system.
127. ~An automated sample processing system as described in claim 124 or 125 wherein said carrier element comprises a movable carrier element.
128. ~An automated sample processing system as described in claim 124 wherein said systematic process detail capture element comprises:
a time of occurrence data capture element, an individual robotic movement data capture element, a substance identifier data capture element, a subject sample data capture element, and a type of protocol data capture element.
129. ~An automated sample processing system as described in claim 122 wherein said systematic process detail capture element comprises a systematic process detail capture element selected from a group consisting of:
a time of occurrence data capture element, a number of occurrence data capture element, a part operation data capture element, an amount of usage data capture element, an amount of material used data capture element, a type of material used data capture element, a substance identifier data capture element, an individual movement data capture element, a robotic action data capture element, an individual robotic movement data capture element, an individual operation data capture element, an individual usage data capture element, an actual date data capture element, an actual time data capture element, a precise time data capture element, a relative time data capture element, an absolute time data capture element, an initiation time data capture element, a completion time data capture element, a subject sample data capture element, a sample image data capture element, an individual sample process data capture element, individual slide log data capture element, a system image data capture element, a substance image data capture element, and a type of protocol data capture element.
130. An automated sample processing system as described in claim 122 wherein said systematic process detail capture element comprises an amount of material used data capture element.
131. An automated sample processing system as described in claim 129 wherein said systematic process detail capture element comprises a robotic action data capture element.~
132. An automated sample processing system as described in claim 131 wherein said~
systematic process detail capture element comprises an individual robotic movement data capture element.
133. An automated sample processing system as described in claim 122 wherein said systematic process detail capture element comprises a precise time data capture element.
134. An automated sample processing system as described in claim 133 wherein said systematic process detail capture element comprises a relative time data capture element.
135. An automated sample processing system as described in claim 133 wherein said systematic process detail capture element comprises an absolute time data capture element.
136. An automated sample processing system as described in claim 122 wherein said systematic process detail capture element comprises an image data capture element.
137. An automated sample processing system as described in claim 136 wherein said image data capture element comprises a sample image data capture element.
138. An automated sample processing system as described in claim 136 wherein said image data capture element comprises a substance image data capture element.
139. ~An automated sample processing system as described in claim 136 wherein said image data capture element comprises a system image data capture element.
140. ~An automated sample processing system as described in claim 136, 137, 138, or 139 wherein said image data capture element comprises a multiple image data capture element.
141. ~An automated sample processing system as described in claim 140 wherein said multiple image data capture element comprises a pre- and post-event image data capture element.
142. ~An automated sample processing system as described in claim 122 wherein said significant process detail memory comprises a segmented computer file memory element.~
143. ~An automated sample processing system as described in claim 122 wherein said significant process detail memory comprises an inalterable computer record memory element.
144. ~An automated sample processing system as described in claim 143 wherein said significant process detail memory comprises an integral change indicia memory element.
145. ~An automated sample processing system as described in claim 142 wherein said significant process detail memory comprises a common format computer record memory element.
146. ~An automated sample processing system as described in claim 142 wherein said significant process detail memory comprises a proprietary format computer record memory element.
147. ~An automated sample processing system as described in claim 122 wherein said information access prompt element comprises a software selection element.
148. ~An automated sample processing system as described in claim 122 wherein said information access prompt element comprises a remote access element.
149. ~An automated sample processing system as described in claim 122 and further comprising a significant process detail information display that is responsive to said significant process detail memory.
150. ~An automated sample processing system as described in claim 149 wherein said significant process detail information display comprises a remote process detail information display.
151. ~An automated sample processing system as described in claim 122 or 149 wherein said significant process detail information display comprises a real time process detail information display.
152. ~An automated sample processing system as described in claim 149 wherein said significant process detail information display comprises a simulated motion process detail information display.
153. ~An automated sample processing system as described in claim 122 and further comprising a sequential playback element.
154. ~An automated sample processing system as described in claim 153 wherein said sequential playback element comprises an altered speed sequential playback element.
155. ~An automated sample processing system as described in claim 154 wherein said altered speed sequential playback element comprises a user alterable speed sequential playback element.
156. ~An automated sample processing system as described in claim 154 wherein said altered speed sequential playback element comprises a high speed sequential playback element.
157. An automated sample processing system as described in claim 122 wherein said systematic process detail capture element comprises an individual slide log data capture element.
158. An automated sample processing system as described in claim 122 and further comprising a real time individual slide log data display.
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Families Citing this family (272)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6183693B1 (en) * 1998-02-27 2001-02-06 Cytologix Corporation Random access slide stainer with independent slide heating regulation
US7951612B2 (en) * 1999-07-08 2011-05-31 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
US8298485B2 (en) * 1999-07-08 2012-10-30 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
AU2002361618A1 (en) 2001-11-13 2003-05-26 Chromavision Medical Systems, Inc. A system for tracking biological samples
US7754155B2 (en) * 2002-03-15 2010-07-13 Ross Amelia A Devices and methods for isolating target cells
US7468161B2 (en) * 2002-04-15 2008-12-23 Ventana Medical Systems, Inc. Automated high volume slide processing system
US11249095B2 (en) 2002-04-15 2022-02-15 Ventana Medical Systems, Inc. Automated high volume slide processing system
ES2424988T3 (en) * 2002-04-15 2013-10-10 Ventana Medical Systems, Inc. Automated slide plate coloring system with high production speed
AU2003901871A0 (en) * 2003-03-31 2003-05-08 Vision Biosystems Limited A method and apparatus for fluid dispensation, preparation and dilation
KR20040023999A (en) * 2002-09-12 2004-03-20 엘지전자 주식회사 structure of motor shaft in clothes dryer
US7584019B2 (en) 2003-12-15 2009-09-01 Dako Denmark A/S Systems and methods for the automated pre-treatment and processing of biological samples
US7850912B2 (en) * 2003-05-14 2010-12-14 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7875245B2 (en) * 2003-05-14 2011-01-25 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7648678B2 (en) * 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
US20060073074A1 (en) * 2004-10-06 2006-04-06 Lars Winther Enhanced sample processing system and methods of biological slide processing
US8719053B2 (en) * 2003-07-17 2014-05-06 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
US20080235055A1 (en) * 2003-07-17 2008-09-25 Scott Mattingly Laboratory instrumentation information management and control network
US7860727B2 (en) 2003-07-17 2010-12-28 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
EP1654066B1 (en) 2003-07-31 2014-11-12 Handylab, Inc. Processing particle-containing samples
US7767152B2 (en) * 2003-08-11 2010-08-03 Sakura Finetek U.S.A., Inc. Reagent container and slide reaction retaining tray, and method of operation
US7744817B2 (en) * 2003-08-11 2010-06-29 Sakura Finetek U.S.A., Inc. Manifold assembly
US7501283B2 (en) * 2003-08-11 2009-03-10 Sakura Finetek U.S.A., Inc. Fluid dispensing apparatus
US9518899B2 (en) * 2003-08-11 2016-12-13 Sakura Finetek U.S.A., Inc. Automated reagent dispensing system and method of operation
US7517498B2 (en) * 2003-08-19 2009-04-14 Agilent Technologies, Inc. Apparatus for substrate handling
EP1733240A4 (en) * 2004-03-02 2007-08-22 Dako Denmark As Reagent delivery system, dispensing device and container for a biological staining apparatus
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US7867443B2 (en) * 2004-07-23 2011-01-11 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7277223B2 (en) * 2004-07-26 2007-10-02 Meade Instruments Corporation Apparatus and methods for focusing and collimating telescopes
US7690275B1 (en) 2004-08-26 2010-04-06 Elemental Scientific, Inc. Automated sampling device
US7637175B1 (en) 2004-08-26 2009-12-29 Elemental Scientific, Inc. Automated sampling device
US7469606B1 (en) * 2004-08-26 2008-12-30 Elemental Scientific, Inc. Automated sampling device
JP4508790B2 (en) * 2004-09-08 2010-07-21 シスメックス株式会社 Sample preparation equipment
US8986614B2 (en) * 2010-02-23 2015-03-24 Rheonix, Inc. Self-contained biological assay apparatus, methods, and applications
US8236255B2 (en) 2004-12-02 2012-08-07 Lab Vision Corporation Slide treatment apparatus and methods for use
JP4659483B2 (en) 2005-02-25 2011-03-30 シスメックス株式会社 Measuring apparatus control method and measuring apparatus
EP1880222B1 (en) * 2005-05-13 2015-10-21 Leica Biosystems Melbourne Pty Ltd Tissue sample identification system and apparatus
AU2012247048B2 (en) * 2005-05-24 2014-11-27 Angros, Lee H In situ heat induced antigen recovery and staining apparatus and method
US8377377B2 (en) 2005-05-24 2013-02-19 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
WO2006127852A2 (en) 2005-05-24 2006-11-30 Angros Lee H In situ heat induced antigen recovery and staining apparatus and method
US7687243B1 (en) 2005-06-06 2010-03-30 Crook Tonia M Automated method for detecting apoptosis in cells
US20070020150A1 (en) * 2005-07-20 2007-01-25 Daquino Lawrence J Adjustment device for drop dispenser
US9134237B2 (en) 2005-09-20 2015-09-15 Janssen Diagnotics, LLC High sensitivity multiparameter method for rare event analysis in a biological sample
EP3211086B1 (en) 2005-09-20 2021-06-09 Menarini Silicon Biosystems S.p.A. Methods and composition to generate unique sequence dna probes, labeling of dna probes and the use of these probes
JP4674150B2 (en) * 2005-11-14 2011-04-20 サクラ精機株式会社 Dyeing and sticking system
EP1954763B1 (en) 2005-11-28 2016-11-16 Dako Denmark A/S Cyanine dyes and methods for detecting a target using said dyes
US20070136099A1 (en) * 2005-12-13 2007-06-14 Gordon Neligh Distributed medicine system
ES2593930T3 (en) 2005-12-19 2016-12-14 Ventana Medical Systems, Inc. Automated label printing for tissue specimen slides
JP4808492B2 (en) * 2005-12-28 2011-11-02 シスメックス株式会社 Specimen Image Imaging Device, Specimen Image Imaging System, and Specimen Slide Supply Device
US7835823B2 (en) * 2006-01-05 2010-11-16 Intuitive Surgical Operations, Inc. Method for tracking and reporting usage events to determine when preventive maintenance is due for a medical robotic system
CN100410652C (en) * 2006-01-12 2008-08-13 上海交通大学 Teaching kit for cell-level organism evolution
US7657070B2 (en) * 2006-01-20 2010-02-02 Sakura Finetek U.S.A., Inc. Automated system of processing biological specimens and method
NO20060555L (en) * 2006-02-02 2007-08-03 Torstein Ljungmann Apparatus for performing treatment operations in connection with staining of tissue samples on slides
DK2001990T3 (en) 2006-03-24 2016-10-03 Handylab Inc Integrated microfluidic sample processing system and method for its use
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8459509B2 (en) * 2006-05-25 2013-06-11 Sakura Finetek U.S.A., Inc. Fluid dispensing apparatus
KR100759079B1 (en) 2006-07-13 2007-09-19 학교법인 포항공과대학교 Medical automatic diagnosis equipment including robot arm
KR100874519B1 (en) * 2006-07-13 2008-12-16 포항공과대학교 산학협력단 Mobile robot and clinical test device using the same
GB2474611B (en) * 2006-09-08 2011-09-07 Thermo Shandon Ltd Image based detector for slides or baskets for use in a slide processing apparatus
US7875242B2 (en) * 2006-10-17 2011-01-25 Preyas Sarabhai Shah Slide stainer with multiple heater stations
EP2091647A2 (en) 2006-11-14 2009-08-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
JP5192168B2 (en) * 2007-03-30 2013-05-08 シスメックス株式会社 Setting information management system, setting information management method, backup program, and storage medium
WO2008143849A2 (en) 2007-05-14 2008-11-27 Historx, Inc. Compartment segregation by pixel characterization using image data clustering
ES2383390T3 (en) * 2007-07-10 2012-06-20 Ventana Medical Systems, Inc. Apparatus and procedure for the treatment of biological samples
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
JP5651011B2 (en) 2007-07-13 2015-01-07 ハンディーラブ インコーポレイテッド Polynucleotide capture material and method of use thereof
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
CA2604317C (en) 2007-08-06 2017-02-28 Historx, Inc. Methods and system for validating sample images for quantitative immunoassays
DE202007013921U1 (en) * 2007-09-16 2007-12-27 Leica Biosystems Nussloch Gmbh Tissue infiltration device
CN101874205B (en) 2007-10-02 2014-10-01 赛拉诺斯股份有限公司 Modular point-of-care devices and uses thereof
AU2008312470B2 (en) * 2007-10-17 2013-07-11 Aushon Biosystems Continual flow pin washer
EP2210080B1 (en) * 2007-10-24 2015-01-28 Biomarker Strategies, Llc Improved methods and devices for cellular analysis
GB0722226D0 (en) * 2007-11-13 2007-12-27 Ruskinn Life Sciences Ltd Gas mixer
WO2009099872A2 (en) * 2008-01-31 2009-08-13 Kacey Med-Vet, Inc. Automated stainer having stain level detection
US8346574B2 (en) 2008-02-29 2013-01-01 Dako Denmark A/S Systems and methods for tracking and providing workflow information
US20090253163A1 (en) * 2008-04-02 2009-10-08 General Electric Company Iterative staining of biological samples
CA3060913A1 (en) * 2008-04-11 2009-10-15 Meso Scale Technologies, Llc. Assay apparatuses, methods and reagents
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US9240043B2 (en) 2008-09-16 2016-01-19 Novartis Ag Reproducible quantification of biomarker expression
EP2172780A1 (en) 2008-10-01 2010-04-07 Bayer Technology Services GmbH Apparatus for automatically performing analyses
AU2009320213B2 (en) * 2008-10-27 2016-06-16 Qiagen Gaithersburg Inc. Fast results hybrid capture assay and system
DE102008054066B4 (en) * 2008-10-31 2015-03-19 Leica Biosystems Nussloch Gmbh Method for processing tissue samples using a sensor
DE102008054071B4 (en) * 2008-10-31 2014-02-20 Leica Biosystems Nussloch Gmbh Method of operating a tissue processor and tissue processor
JP5474080B2 (en) * 2008-11-12 2014-04-16 ヴェンタナ メディカル システムズ, インコーポレイテッド Device for heating the specimen-carrying slide
EP2406679B1 (en) 2009-03-11 2017-01-25 Sakura Finetek U.S.A., Inc. Autofocus method and autofocus device
US8489545B2 (en) * 2009-03-18 2013-07-16 Norman Ritchie System and method for creating and maintaining pre-task planning documents
DE102009015596A1 (en) 2009-03-30 2010-10-21 Dcs Innovative Diagnostik-Systeme Dr. Christian Sartori Gmbh & Co. Kg Method and device for the treatment of carrier-fixed material
BE1018828A3 (en) * 2009-07-16 2011-09-06 Praet Peter Van INTELLIGENT RACK FOR SPECIMEN TUBES AND METHOD OF LOADING THE TUBES INTO THE RACK.
US8407011B2 (en) * 2009-08-03 2013-03-26 Empire Technology Development Llc Mobile sampling of target substances
JP5275182B2 (en) * 2009-09-11 2013-08-28 株式会社日立ハイテクノロジーズ Dispensing device and analyzer
DE102009049375B4 (en) * 2009-10-14 2014-07-24 Leica Instruments (Singapore) Pte. Ltd. Device for processing tissue samples
EP2494353B1 (en) * 2009-10-30 2017-09-27 Illumina Inc. An apparatus comprising a plurality of encoded microvessels and a plurality of compartments and a method of reading a plurality of encoded micro vessels
US10746752B2 (en) 2009-11-13 2020-08-18 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
WO2011066269A1 (en) 2009-11-24 2011-06-03 Siemens Healthcare Diagnostics Inc. Automated, refrigerated specimen inventory management system
US8765476B2 (en) * 2009-12-22 2014-07-01 Biocare Medical, Llc Methods and systems for efficient automatic slide staining in immunohistochemistry sample processing
US9102979B2 (en) 2010-02-23 2015-08-11 Rheonix, Inc. Self-contained biological assay apparatus, methods, and applications
DE102010036317B4 (en) * 2010-07-09 2020-07-30 Leica Biosystems Nussloch Gmbh Automatic adjustment of a dyeing device
US10139613B2 (en) 2010-08-20 2018-11-27 Sakura Finetek U.S.A., Inc. Digital microscope and method of sensing an image of a tissue sample
EP3779433A3 (en) * 2010-08-30 2021-05-19 Konica Minolta, Inc. Tissue staining method, tissue evaluation method and biosubstance detection method
WO2012048154A1 (en) 2010-10-06 2012-04-12 Biocare Medical, Llc Methods and systems for efficient processing of biological samples
CN103282780B (en) * 2010-10-29 2015-07-08 美诺生命科技(武汉)股份有限公司 Apparatus for processing biological samples and method thereof
EP2638404B1 (en) * 2010-11-12 2021-09-15 Gen-Probe Incorporated System and method for tracking items during a process
DE102010054360B4 (en) * 2010-12-13 2018-09-20 Leica Biosystems Nussloch Gmbh Device, rack turning module, system and method for turning racks
CN102081414B (en) * 2010-12-21 2013-08-28 北京赛科希德科技发展有限公司 Method and system for controlling temperature of sample adding needle
US8388891B2 (en) * 2010-12-28 2013-03-05 Sakura Finetek U.S.A., Inc. Automated system and method of processing biological specimens
US8572556B2 (en) 2010-12-31 2013-10-29 Starlims Corporation Graphically based method for developing connectivity drivers
AU2012205849A1 (en) * 2011-01-10 2013-07-04 Ventana Medical Systems, Inc. Hematoxylin staining method
CA2825196C (en) 2011-01-21 2021-01-05 Theranos, Inc. Systems and methods for sample use maximization
CN102175498B (en) * 2011-01-31 2012-11-14 浙江世纪康大医疗科技有限公司 Tube-taking and liquid-adding device of dyeing instrument
US8752732B2 (en) 2011-02-01 2014-06-17 Sakura Finetek U.S.A., Inc. Fluid dispensing system
DE102011011360A1 (en) * 2011-02-16 2012-08-16 Steinbichler Optotechnik Gmbh Apparatus and method for determining the 3-D coordinates of an object and for calibrating an industrial robot
US9945763B1 (en) 2011-02-18 2018-04-17 Biocare Medical, Llc Methods and systems for immunohistochemistry heat retrieval of biological samples
JP6013376B2 (en) * 2011-02-28 2016-10-25 ダコ・デンマーク・エー/エス Two-phase immiscible system for pretreatment of embedded biological samples
US9140666B2 (en) 2012-03-15 2015-09-22 Advanced Analytical Technologies, Inc. Capillary electrophoresis system
CN102735518A (en) * 2011-04-13 2012-10-17 苏州卫生职业技术学院 Bacterial examination staining rack used for teaching
RU2690374C2 (en) 2011-04-15 2019-06-03 Бектон, Дикинсон Энд Компани Scanning in real time microfluid thermal cycler and methods of synchronized thermal cycling and scanning optical detection
US9123002B2 (en) 2011-05-27 2015-09-01 Abbott Informatics Corporation Graphically based method for developing rules for managing a laboratory workflow
US9665956B2 (en) 2011-05-27 2017-05-30 Abbott Informatics Corporation Graphically based method for displaying information generated by an instrument
JP6113725B2 (en) * 2011-07-22 2017-04-12 ロッシュ ダイアグノスティクス ヘマトロジー インコーポレイテッド Sample transfer system and transfer method
US20130060534A1 (en) * 2011-09-02 2013-03-07 Sigma-Aldrich Co., Llc Systems and methods for validating and customizing oligonucleotides sequences
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US8580568B2 (en) 2011-09-21 2013-11-12 Sakura Finetek U.S.A., Inc. Traceability for automated staining system
JP5686710B2 (en) * 2011-09-21 2015-03-18 株式会社日立ハイテクノロジーズ Automatic analyzer
US8932543B2 (en) 2011-09-21 2015-01-13 Sakura Finetek U.S.A., Inc. Automated staining system and reaction chamber
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
CA2849917C (en) 2011-09-30 2020-03-31 Becton, Dickinson And Company Unitized reagent strip
JP5805486B2 (en) * 2011-09-30 2015-11-04 シスメックス株式会社 Sample analyzer
IN2014DN03406A (en) * 2011-09-30 2015-06-26 Life Technologies Corp
DE102011114674C5 (en) 2011-09-30 2020-05-28 Steinbichler Optotechnik Gmbh Method and device for determining the 3D coordinates of an object
US9495741B2 (en) 2011-09-30 2016-11-15 Life Technologies Corporation Methods and systems for streamlining optical calibration
US9865049B2 (en) 2011-09-30 2018-01-09 Life Technologies Corporation Methods and systems for background subtraction in an image
CN103975230A (en) * 2011-10-17 2014-08-06 胜利医疗系统有限责任公司 Method, apparatus and system for staining of biological samples
EP2773892B1 (en) 2011-11-04 2020-10-07 Handylab, Inc. Polynucleotide sample preparation device
CN102519775A (en) * 2011-11-15 2012-06-27 深圳市科软科技有限公司 Automatic slide stainer
US9395284B2 (en) 2011-11-16 2016-07-19 Leica Biosystems Melbourne Pty Ltd Automated system and method of treating tissue samples on slides
WO2013071358A2 (en) 2011-11-16 2013-05-23 Leica Biosystems Melbourne Pty Ltd Biological sample treatment apparatus
US20130137136A1 (en) * 2011-11-30 2013-05-30 Dako Denmark A/S Method and system for automated deparaffinization and non-immunohistochemical special staining of tissue samples
US9268619B2 (en) 2011-12-02 2016-02-23 Abbott Informatics Corporation System for communicating between a plurality of remote analytical instruments
BR112014018995B1 (en) 2012-02-03 2021-01-19 Becton, Dickson And Company systems to perform automated testing
CN103245547A (en) * 2012-02-12 2013-08-14 高新春 Glass biological-sample section-staining support
US11340191B2 (en) 2012-03-15 2022-05-24 Agilent Technologies, Inc. UV-absorbance multichannel capillary electrophoresis system
US11016057B2 (en) 2012-03-15 2021-05-25 Agilent Technologies, Inc. Pulse-field multiplex capillary electrophoresis system
US10041950B2 (en) 2012-03-27 2018-08-07 Ventana Medical Systems, Inc. Signaling conjugates and methods of use
US20130294826A1 (en) * 2012-05-04 2013-11-07 Advanced Cell Diagnostics, Inc. Lock-in slide rack
US10829291B2 (en) * 2012-06-20 2020-11-10 Thermo Fischer Scientific Baltics UAB Method to prevent silica-based column aging
US9817221B2 (en) 2012-06-29 2017-11-14 General Electric Company Systems and methods for processing and imaging of biological samples
WO2014001531A2 (en) * 2012-06-29 2014-01-03 Victorious Medical Systems Aps A system and a dip tank for washing and target retrieval of tissue samples mounted on microscope slides
US9164015B2 (en) * 2012-06-29 2015-10-20 General Electric Company Systems and methods for processing and imaging of biological samples
US9530053B2 (en) * 2012-07-31 2016-12-27 Tecan Trading Ag Method and apparatus for detecting or checking an arrangement of laboratory articles on a work area of a laboratory work station
CH706772A1 (en) * 2012-07-31 2014-01-31 Tecan Trading Ag Method and apparatus for detecting and verifying an array of laboratory products on a working area of ​​a laboratory workstation.
WO2014036593A1 (en) 2012-09-04 2014-03-13 Leica Biosystems Melbourne Pty Ltd Cover member with orientation indicia
JP6289473B2 (en) * 2012-09-05 2018-03-07 セファイド Universal docking bay and data door in fluid analysis system
WO2014038408A1 (en) 2012-09-06 2014-03-13 ソニー株式会社 Information processing device, information processing method, and program
US9341229B1 (en) 2012-09-10 2016-05-17 Elemental Scientific, Inc. Automated sampling device
CN102854050A (en) * 2012-09-29 2013-01-02 梁建中 Fully-automatic double-rail staining instrument for frozen sections
US10668622B2 (en) * 2012-10-11 2020-06-02 Siemens Healthcare Diagnostics Inc. Automation maintenance carrier
US10473558B2 (en) 2012-11-13 2019-11-12 Ues, Inc. Automated high speed metallographic system
WO2014075693A1 (en) * 2012-11-16 2014-05-22 Dako Denmark A/S Method and apparatus for reagent validation in automated sample processing
EP2925450B1 (en) * 2012-12-03 2017-09-13 Leica Biosystems Melbourne Pty Ltd Thermal module for a sample processing assembly
US11274998B2 (en) 2012-12-26 2022-03-15 Ventana Medical Systems, Inc. Specimen processing systems and methods for holding slides
US9989448B2 (en) 2012-12-26 2018-06-05 Ventana Medical Systems, Inc. Specimen processing systems and methods for holding slides
CN104870972A (en) * 2012-12-26 2015-08-26 文塔纳医疗系统公司 Automated specimen processing systems and methods of using the same
GB2510466B (en) 2012-12-28 2015-05-06 Leica Biosystems Nussloch Gmbh Processor for processing histological samples
JP6416785B2 (en) 2013-01-04 2018-10-31 メソ スケール テクノロジーズ エルエルシー Instrument for electrochemiluminescence analysis using multiwell plate and contact platform
KR20150119365A (en) * 2013-02-18 2015-10-23 테라노스, 인코포레이티드 Systems and methods for multi-analysis
WO2014144759A1 (en) 2013-03-15 2014-09-18 Abbott Laboratories Linear track diagnostic analyzer
US9513303B2 (en) 2013-03-15 2016-12-06 Abbott Laboratories Light-blocking system for a diagnostic analyzer
WO2014144825A2 (en) 2013-03-15 2014-09-18 Abbott Laboratories Automated reagent manager of a diagnostic analyzer system
US11865544B2 (en) 2013-03-15 2024-01-09 Becton, Dickinson And Company Process tube and carrier tray
US10220392B2 (en) 2013-03-15 2019-03-05 Becton, Dickinson And Company Process tube and carrier tray
MX2015011194A (en) 2013-03-15 2016-03-04 Becton Dickinson Co Process tube and carrier tray.
DE102013103971A1 (en) 2013-04-19 2014-11-06 Sensovation Ag Method for generating an overall picture of an object composed of several partial images
US10422806B1 (en) 2013-07-25 2019-09-24 Theranos Ip Company, Llc Methods for improving assays of biological samples
CN103398890B (en) * 2013-08-22 2015-11-11 麦克奥迪(厦门)医疗诊断系统有限公司 A kind of liquid-based cell sample manufacturing system and flaking method thereof
US20150095058A1 (en) * 2013-10-02 2015-04-02 Health Diagnostic Laboratory, Inc. Methods for laboratory sample tracking and devices thereof
CN104630055A (en) * 2013-11-08 2015-05-20 西安科技大学 Main control board of in-situ hybridization system
USD761439S1 (en) * 2013-11-18 2016-07-12 Especialidades Médicas Myr, S.L. Apparatus and equipment for doctors, hospitals and laboratories
WO2015086484A1 (en) 2013-12-13 2015-06-18 Ventana Medical Systems, Inc. Automated histological processing of biological specimens and associated technology
ES2877855T3 (en) 2013-12-13 2021-11-17 Ventana Med Syst Inc Staining reagents and other liquids for histological processing of biological samples and associated technology
WO2015086485A1 (en) 2013-12-13 2015-06-18 Ventana Medical Systems, Inc. Thermal management in the context of automated histological processing of biological specimens and associated technology
US10007102B2 (en) 2013-12-23 2018-06-26 Sakura Finetek U.S.A., Inc. Microscope with slide clamping assembly
KR102175186B1 (en) * 2014-01-17 2020-11-06 주식회사 수젠텍 Auto analysis system for strip
US9347965B1 (en) * 2014-03-13 2016-05-24 EST Analytical, Inc. Autosampler with enhanced expansion capability
WO2015165019A1 (en) * 2014-04-28 2015-11-05 深圳迈瑞生物医疗电子股份有限公司 Smear preparation device, smear preparation method and glass slide basket drying module
JP6187685B2 (en) * 2014-05-20 2017-08-30 株式会社島津製作所 Sample introduction system
CN104148265B (en) * 2014-06-16 2015-09-23 来安县新元机电设备设计有限公司 For electrostatic powder spraying workpiece automation pre-processing device
WO2016001082A1 (en) * 2014-06-30 2016-01-07 Ventana Medical Systems, Inc. Automated specimen processing systems and methods
CN104089804B (en) * 2014-07-02 2019-04-05 上海乐辰生物科技有限公司 Biological sample processing system
US11441975B2 (en) * 2014-07-02 2022-09-13 Shimadzu Corporation Controlling method of preprocessing apparatus
CN104122127A (en) * 2014-07-18 2014-10-29 东南大学 Biological sample treatment device
CN104101529B (en) * 2014-07-27 2016-07-20 李强 pathological staining device
USD814653S1 (en) 2014-08-07 2018-04-03 Becton, Dickinson And Company Sample tube holder and components thereof
JP6278199B2 (en) * 2014-08-20 2018-02-14 株式会社島津製作所 Analyzer management system
CN105578837B (en) * 2014-10-16 2018-06-26 华为技术有限公司 Remote Radio Unit and active antenna system
DK3207379T3 (en) 2014-10-19 2023-08-21 Kamal Prasad Peddinti Automated batch staining device for immunohistochemistry
US10190950B2 (en) 2014-10-31 2019-01-29 General Electric Company Semi-automated sampling system for aseptic sampling
CN105890959A (en) * 2014-11-24 2016-08-24 王素蓉 Staining instrument and control method for staining instrument
CN104502171B (en) * 2014-11-27 2017-05-31 嘉兴凯实生物科技有限公司 A kind of automatic fluorescence sheet stainer
CN104849121A (en) * 2015-02-06 2015-08-19 上海乐辰生物科技有限公司 Biological sample treating instrument
CN104777027B (en) * 2015-03-25 2017-03-22 江苏硕世生物科技有限公司 Multifunctional full-automatic gram staining instrument
WO2016164431A1 (en) 2015-04-06 2016-10-13 Nanocytomics, LLC Automated specimen deposition systems and associated methods
US10091279B2 (en) 2015-05-27 2018-10-02 FlowJo, LLC Wireless connected laboratory
CA2987397C (en) 2015-05-29 2022-03-01 Illumina, Inc. Sample carrier and assay system for conducting designated reactions
US10379130B2 (en) 2015-06-26 2019-08-13 Abbott Laboratories Reaction vessel exchanger device for a diagnostic analyzer
EP3115766A1 (en) 2015-07-10 2017-01-11 3Scan Inc. Spatial multiplexing of histological stains
CA3014617C (en) 2016-02-17 2023-08-22 Becton, Dickinson And Company Automated sample preparation system for diagnostic testing of same
CN105676907B (en) * 2016-03-25 2018-12-28 丁鸿 A kind of temperature control equipment and constant-temperature control method
CN105903500B (en) * 2016-04-18 2018-04-03 佛山盈诺科创投资咨询中心(有限合伙) A kind of reagent arranges formula adding set
EP3446129B1 (en) 2016-04-22 2024-02-14 Becton, Dickinson and Company Automated diagnostic analyzer and method for its operation
EP4234182A2 (en) 2016-04-22 2023-08-30 Becton, Dickinson and Company Automated analyzer piercing stoppers for aspiration
EP3449235B1 (en) * 2016-04-29 2021-09-01 Biocare Medical, LLC Biological sample processing systems and methods
JP6243965B2 (en) 2016-05-26 2017-12-06 シスメックス株式会社 Smear preparation apparatus and smear preparation method
US11460383B2 (en) 2016-06-16 2022-10-04 Nanocytomics, LLC Automated staining system
AU2017282153B2 (en) 2016-06-20 2022-08-04 Genesis Technologies Limited Automated cell processing systems and methods
CN110249350A (en) * 2016-09-20 2019-09-17 河谷控股Ip有限责任公司 Sample tracking, system and method are carried out via sample tracking chain
WO2018085608A2 (en) * 2016-11-04 2018-05-11 Ues, Inc. Automated high speed metallographic system
CN106370830A (en) * 2016-11-14 2017-02-01 漯河医学高等专科学校 Molecular pathology device with independent slip sheet heater
US11280803B2 (en) 2016-11-22 2022-03-22 Sakura Finetek U.S.A., Inc. Slide management system
CN106782464A (en) * 2016-12-01 2017-05-31 北京银河润泰科技有限公司 Keyboard action detection method and device
CN106979883B (en) * 2016-12-19 2019-10-29 浙江世纪康大医疗科技股份有限公司 A kind of dyeing instrument drawer type reagent device
WO2018119321A1 (en) * 2016-12-22 2018-06-28 Counsyl, Inc. Automatic diagnostic laboratory and laboratory information management system for high throughput
EP3601995A4 (en) * 2017-03-31 2020-12-16 X-Zell Inc. Automatic slide staining and cooling systems
US20180372766A1 (en) * 2017-06-21 2018-12-27 Abbott Molecular Inc. Analysis Systems and Methods of Identifying Consumables and Reagents
WO2019023948A1 (en) * 2017-08-01 2019-02-07 深圳华大智造科技有限公司 Gene sequencing reaction device, gene sequencing system, and gene sequencing reaction method
WO2019023947A1 (en) * 2017-08-01 2019-02-07 深圳华大智造科技有限公司 Dna sample loading device, gene sequencing system, and dna sample loading method
US10816562B2 (en) 2017-10-04 2020-10-27 Leica Biosystems Imaging, Inc. Slide inventory and reinsertion system
CN107907396B (en) * 2017-11-07 2020-11-10 山西大学 Automatic immunohistochemical staining system for biological tissues
CN107860632B (en) * 2017-11-07 2020-01-03 山西大学 Automatic immunohistochemical device of fruit bat wing bud
KR102105233B1 (en) * 2017-12-06 2020-06-05 권택민 A laboratory mixer suitable for viscous sample of small quantity
WO2019119037A1 (en) * 2017-12-21 2019-06-27 Leica Biosystems Melbourne Pty Ltd A fluid transport system
WO2019152604A1 (en) * 2018-02-01 2019-08-08 Beckman Coulter, Inc. Image-based deck verification
US20190308191A1 (en) * 2018-04-07 2019-10-10 Lumacyte, LLC Fluidic autosampler and incubator
WO2019241647A1 (en) * 2018-06-15 2019-12-19 Weiderin Daniel R System for prioritization of collecting and analyzing liquid samples
CN109031446A (en) * 2018-07-18 2018-12-18 杭州依美洛克医学科技有限公司 Glass slide detection device
CN109082375A (en) * 2018-09-14 2018-12-25 深圳华云智能装备科技有限公司 A kind of system of sample detection
CN110525974A (en) * 2018-09-21 2019-12-03 安徽恒春玻璃股份有限公司 A kind of glass auto loading machine
CN112740046A (en) * 2018-09-25 2021-04-30 株式会社日立高新技术 Automatic analyzer
CN108872040A (en) * 2018-09-30 2018-11-23 徐州工业职业技术学院 A kind of city haze monitoring system
JP7422746B2 (en) * 2018-12-14 2024-01-26 ライカ・バイオシステムズ・メルボルン・プロプライエタリー・リミテッド reagent cassette
CN109297796A (en) * 2018-12-19 2019-02-01 孝感市森茂激光数控设备有限公司 A kind of sampling of automatic sedimentation pelleter and dye liquor injection device and method
CN113226553B (en) * 2018-12-20 2023-05-23 帝肯贸易股份公司 Method for processing a sample
CN109490045B (en) * 2018-12-25 2022-05-27 宁波察微生物科技有限公司 Slide glass dyeing and mounting all-in-one machine
CN111435108A (en) * 2019-01-11 2020-07-21 蒋洪棉 KD series biological tissue treatment dyeing machine
US20200309649A1 (en) * 2019-03-08 2020-10-01 Samantree Medical Sa Receptacles for staining and/or rinsing samples and methods of their use
US11415409B1 (en) * 2019-08-22 2022-08-16 Charles S. Powers Apparatuses and methods for measuring parameters of an object
CN110631883B (en) * 2019-08-23 2022-05-17 山东滨州拓普化工工程有限公司 High-efficient automatic dyeing appearance
FR3101149B1 (en) * 2019-09-19 2024-02-09 Dreampath Diagnostics Equipment for the traceability of biological samples
CN110865579A (en) * 2019-11-26 2020-03-06 张家港宏昌钢板有限公司 Factory energy and power configuration management and control system
US20210285650A1 (en) * 2020-03-10 2021-09-16 Illinois Tool Works Inc. Drum heater assembly
US11146491B1 (en) * 2020-04-09 2021-10-12 International Business Machines Corporation Dynamically balancing inbound traffic in a multi-network interface-enabled processing system
MX2020007710A (en) * 2020-07-20 2022-01-21 Jesus Raul Beltran Ramirez Automated device for staining multiple histological samples.
JP7014460B1 (en) * 2020-09-30 2022-02-01 株式会社常光 Paraffin embedding block making equipment
CN112945956B (en) * 2021-02-04 2023-06-27 广东小天才科技有限公司 Slide loading detection method and device, terminal equipment and storage medium
US11501623B1 (en) 2021-05-14 2022-11-15 China University Of Geosciences (Wuhan) Arrangement apparatus for multiple integrated sensors in deep position of sliding mass and arrangement method
US11281194B1 (en) * 2021-05-25 2022-03-22 Art Research And Technology, L.L.C. Immune pathway management system
CN113759842B (en) * 2021-08-26 2022-05-17 武汉康录生物技术股份有限公司 Control system for FISH detection
EP4246392A1 (en) 2022-03-15 2023-09-20 F. Hoffmann-La Roche AG Forecasting future laboratory performance
WO2024033954A1 (en) * 2022-08-09 2024-02-15 Logibiotech S.R.L. Device adapted to retrieve histological slides and/or biocassettes
CN116465709B (en) * 2023-04-19 2023-12-29 杭州海世嘉生物科技有限公司 Full-automatic immunohistochemical dyeing machine control method, system and storage medium

Family Cites Families (496)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US495710A (en) * 1893-04-18 Territory
US159875A (en) * 1875-02-16 Improvement in harvester-droppers
US1829341A (en) * 1930-01-11 1931-10-27 William C Denison Air conditioning device
US3219416A (en) 1962-10-30 1965-11-23 Scientific Industries Apparatus for the automatic chemical sequential treatment and analysis of small quantities of material
US3398935A (en) 1964-03-25 1968-08-27 Bausch & Lomb Mixing means
US4018556A (en) * 1965-12-03 1977-04-19 Societe Anonyme Dite: L'oreal Hair dye compounds
US3482082A (en) 1966-03-18 1969-12-02 Techicon Corp Sample identification apparatus
US4066412A (en) * 1966-04-26 1978-01-03 E. I. Du Pont De Nemours And Company Automatic clinical analyzer
US3513320A (en) 1966-10-31 1970-05-19 Markstems Inc Article identification system detecting plurality of colors disposed on article
US3574064A (en) 1968-05-09 1971-04-06 Aerojet General Co Automated biological reaction instrument
US3547064A (en) 1968-08-21 1970-12-15 Cava Ind Planing step
GB1299613A (en) 1968-12-21 1972-12-13 Olympus Optical Co Device for use in measuring automatically a parameter of liquid samples
US3553438A (en) 1969-07-18 1971-01-05 Sylvania Electric Prod Mark sensing system
CH513393A (en) 1969-08-28 1971-09-30 Greiner Electronic Ag Process for performing chemical and / or physical analyzes in series
US3644715A (en) 1969-09-22 1972-02-22 Becton Dickinson Co Machine readable label and sample identification system utilizing the same
US3600900A (en) 1969-11-03 1971-08-24 North American Rockwell Temperature controlled centrifuge
US3916157A (en) 1970-09-08 1975-10-28 Mmbi Inc Specimen carrier
US3680967A (en) 1970-09-14 1972-08-01 Technicon Instr Self-locating sample receptacle having integral identification label
US3772154A (en) 1971-05-03 1973-11-13 Technicon Instr Method and apparatus for automated antibiotic susceptibility analysis of bacteria samples
US3772164A (en) * 1971-08-16 1973-11-13 Micromatic Ind Inc Honing and plating apparatus and method embodying bore gauging means
US3971917A (en) 1971-08-27 1976-07-27 Maddox James A Labels and label readers
BE788877A (en) 1971-09-17 1973-01-02 Vickers Ltd AGITATION OF LIQUID SAMPLES TO OBTAIN HOMOGENOUS MIXTURES
US3861006A (en) * 1971-11-23 1975-01-21 Wellman Co Coupling device for a cutting machine
US3916160A (en) 1971-12-13 1975-10-28 Bendix Corp Coded label for automatic reading systems
US3807851A (en) 1972-06-06 1974-04-30 Minnesota Mining & Mfg Slide identification clip
US3876297A (en) 1972-06-06 1975-04-08 Minnesota Mining & Mfg Slide identification
US3801775A (en) 1972-08-07 1974-04-02 Scanner Method and apparatus for identifying objects
GB1409613A (en) * 1972-09-21 1975-10-08 Geimuplast Mundt Kg Peter Apparatus for welding together a base part and a cover part of a photographic slide frame
US3831006A (en) 1973-01-19 1974-08-20 Honeywell Inc Patient-specimen identification system using stored associated numbers
FR2239167A6 (en) 1973-07-26 1975-02-21 Ministere Agriculture Service Machine for carrying out laboratory analyses - has automatic sample transfer, reactant addition and washing of transfer pipettes
US3851972A (en) 1973-10-18 1974-12-03 Coulter Electronics Automatic method and system for analysis and review of a plurality of stored slides
US3853092A (en) 1973-10-25 1974-12-10 Corning Glass Works Apparatus for nutating and staining a microscope slide
USRE28585E (en) 1973-10-25 1975-10-28 Apparatus for nutating and staining a microscope slide
US3873079A (en) 1974-01-04 1975-03-25 Byron Jackson Inc Belleville spring cartridge
GB1453226A (en) 1974-01-30 1976-10-20 Newman Howells Associates Ltd Apparatus for the treatment or processing of histological and other specimens or apparatus
US3912456A (en) * 1974-03-04 1975-10-14 Anatronics Corp Apparatus and method for automatic chemical analysis
JPS5414287Y2 (en) 1974-05-08 1979-06-13
US3909203A (en) 1974-08-04 1975-09-30 Anatronics Corp Analysis system having random identification and labeling system
US4084541A (en) * 1975-04-22 1978-04-18 Olympus Optical Co., Ltd. Dyeing and decolorization apparatus for use in a blood serum analyzer of an electrophoretic type
USRE30730E (en) 1975-06-11 1981-09-01 National Research Development Corporation Apparatus for use in investigating specimens
US4013038A (en) * 1975-07-21 1977-03-22 Corning Glass Works Apparatus for controlling the temperature of a liquid body
US4013157A (en) * 1975-07-30 1977-03-22 Bally Manufacturing Corporation Bonus play machine
GB1506058A (en) 1975-08-13 1978-04-05 Secr Social Service Brit Liquid storage apparatus
US3994594A (en) 1975-08-27 1976-11-30 Technicon Instruments Corporation Cuvette and method of use
US4018565A (en) * 1975-10-17 1977-04-19 The Foxboro Company Automatic process titration system
JPS5295121A (en) 1976-02-06 1977-08-10 Hitachi Ltd Code plate
US4012038A (en) * 1976-03-03 1977-03-15 Brotz Gregory R Magnetic toy
GB1561061A (en) 1976-03-17 1980-02-13 Hycel Inc Reaction conveyor assembly in an automatic chemical testing apparatus
DE2642019C2 (en) * 1976-09-18 1982-06-03 Robert Bosch Gmbh, 7000 Stuttgart Method for reproducing video signals recorded in individual tracks on a recording medium - preferably magnetic tape
US4159875A (en) 1976-10-21 1979-07-03 Abbott Laboratories Specimen holder
GB1595296A (en) 1976-12-03 1981-08-12 Nat Res Dev Automation of discrete analysis systems
US4298571A (en) 1976-12-17 1981-11-03 Eastman Kodak Company Incubator including cover means for an analysis slide
US4200056A (en) * 1977-01-21 1980-04-29 Miles Laboratories, Inc. Segmented platen for applying liquids to a flat surface
US4115861A (en) 1977-03-28 1978-09-19 Instrumentation Specialties Company Chemical analyzer
US4113038A (en) * 1977-04-18 1978-09-12 Clark George M Drilling jar
JPS5414287A (en) 1977-07-04 1979-02-02 Toshiba Corp Stress sensor using elastic surface wave elements
US4100309A (en) 1977-08-08 1978-07-11 Biosearch Medical Products, Inc. Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same
US4092952A (en) 1977-08-19 1978-06-06 Wilkie Ronald N Automatic slide stainer
US4135883A (en) 1977-08-29 1979-01-23 Bio-Dynamics Inc. Blood analyzer system
US4133437A (en) * 1977-09-09 1979-01-09 Helper Industries, Inc. Wheel chair lift apparatus
FR2403465A2 (en) * 1977-09-16 1979-04-13 Valois Sa MANUAL PISTON PUMP FOR DISTRIBUTION OR SPRAYING
JPS5473094A (en) * 1977-11-21 1979-06-12 Olympus Optical Co Ltd Automatic chemical analytical apparatus
US4227810A (en) 1978-01-26 1980-10-14 Technicon Instruments Corporation Cuvette and method of use
US4133642A (en) * 1978-03-10 1979-01-09 Terumo Corporation Pipetting apparatus for automatic analyzer
US4413584A (en) * 1978-04-19 1983-11-08 A.J.P. Scientific, Inc. Biological slide staining apparatus
JPS55107957U (en) 1979-01-25 1980-07-29
JPS55107957A (en) 1979-02-13 1980-08-19 Agency Of Ind Science & Technol Analyzing method of blood image
JPS55136957A (en) 1979-04-14 1980-10-25 Olympus Optical Co Ltd Automatic analyzer
JPS55136958A (en) 1979-04-14 1980-10-25 Olympus Optical Co Ltd Automatic analyzer
JPS55140155A (en) * 1979-04-19 1980-11-01 Olympus Optical Co Ltd Distribution device
JPS55144550A (en) * 1979-04-28 1980-11-11 Olympus Optical Co Ltd Automatic analyzer
US4281387A (en) 1979-05-21 1981-07-28 American Home Products Corp. Automatic chemical analysis apparatus and method
US4263504A (en) 1979-08-01 1981-04-21 Ncr Corporation High density matrix code
US4406547A (en) 1979-08-07 1983-09-27 Olympus Optical Company Limited Apparatus for effecting automatic analysis
US4346056A (en) 1979-08-15 1982-08-24 Olympus Optical Company Limited Automatic analyzing apparatus
US4318885A (en) * 1979-09-10 1982-03-09 Olympus Optical Co., Ltd. Liquid treating device for chemical analysis apparatus
US4331176A (en) * 1980-03-03 1982-05-25 American Standard Inc. Replaceable cartridge valve assembly
DE3035340C2 (en) 1980-09-19 1983-03-31 Boehringer Ingelheim Diagnostika GmbH, 8046 Garching Method and device for the distribution of samples from primary vessels
US4323537A (en) 1980-10-20 1982-04-06 Instrumentation Laboratory Inc. Analysis system
JPS5782769A (en) * 1980-11-10 1982-05-24 Hitachi Ltd Automatic analyzing device
JPH0217341Y2 (en) 1981-02-10 1990-05-15
US4404641A (en) 1981-02-17 1983-09-13 Dierckx Equipment Corporation Maintenance monitor
US4371498A (en) 1981-06-19 1983-02-01 Medical Laboratory Automation, Inc. Coded cuvette for use in testing apparatus
US4467603A (en) 1981-07-08 1984-08-28 Wilson William L Torque transfer apparatus
ES275136Y (en) 1981-07-20 1984-10-01 American Hospital Supply Corporation ANCHORING DEVICE FOR PELDANS IN CONCRETE PIECES OR SIMILAR.
JPS58105065A (en) * 1981-12-17 1983-06-22 Olympus Optical Co Ltd Analyzer based on emmunological agglutination
US4447395A (en) * 1982-02-12 1984-05-08 The United States Of America As Represented By The Secretary Of The Army Sampling device
US5202252A (en) * 1982-03-05 1993-04-13 Houston Biotechnology Inc. Monoclonal antibodies against lens epithelial cells and methods for preventing proliferation of remnant lens epithelial cells after extracapsular extraction
GB2116711B (en) 1982-03-17 1985-07-31 Vickers Plc Automatic chemical analysis
US4571699A (en) 1982-06-03 1986-02-18 International Business Machines Corporation Optical mark recognition for controlling input devices, hosts, and output devices
US4539632A (en) 1982-09-28 1985-09-03 Borg-Warner Corporation Programmable maintenance timer system
US4467073A (en) 1982-10-20 1984-08-21 Hydromer, Inc. Transparent anti-fog coating compositions
US4488679A (en) 1982-11-01 1984-12-18 Western Publishing Company, Inc. Code and reading system
US4647432A (en) * 1982-11-30 1987-03-03 Japan Tectron Instruments Corporation Tokuyama Soda Kabushiki Kaisha Automatic analysis apparatus
US5175086A (en) 1983-01-24 1992-12-29 Olympus Optical Co., Ltd. Method for effecting heterogeneous immunological analysis
GB8302108D0 (en) 1983-01-26 1983-03-02 Ventana Ltd Ventilators
US4585622A (en) * 1983-02-02 1986-04-29 Ae/Cds, Autoclave, Inc. Chemical microreactor having close temperature control
EP0117262B1 (en) 1983-02-25 1988-04-20 Winfried Dr. med. Stöcker Processes and devices for examinations on immobilised biological material
US4538222A (en) * 1983-04-06 1985-08-27 Halliburton Company Apparatus and method for mixing a plurality of substances
US4510169A (en) * 1983-08-23 1985-04-09 The Board Of Regents, The University Of Texas Method and apparatus for cryopreparing biological tissue for ultrastructural analysis
US4634850A (en) 1983-10-12 1987-01-06 Drexler Technology Corporation Quad density optical data system
US4609017A (en) 1983-10-13 1986-09-02 Coulter Electronics, Inc. Method and apparatus for transporting carriers of sealed sample tubes and mixing the samples
US4683120A (en) 1983-10-28 1987-07-28 Gamma Biologicals, Inc. Biological fluid assay system
US4624588A (en) 1983-11-08 1986-11-25 Maverick Microsystems, Inc. Full field MICR encoder
DE3578454D1 (en) 1984-02-01 1990-08-02 Baxter Int CLINICAL ANALYSIS SYSTEM AND METHOD.
JPH0723895B2 (en) 1984-02-13 1995-03-15 オリンパス光学工業株式会社 Method for controlling reagent amount of automatic analyzer
DE3405292A1 (en) 1984-02-15 1985-09-05 Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg METHOD FOR CARRYING OUT SAMPLES AND RACK FOR CARRYING OUT THE METHOD
US4961906A (en) 1984-04-12 1990-10-09 Fisher Scientific Company Liquid handling
JPS6126863A (en) * 1984-07-17 1986-02-06 Konishiroku Photo Ind Co Ltd Biochemical analysis instrument
US4567748A (en) * 1984-07-19 1986-02-04 Klass Carl S On-line linear tonometer
AU571727B2 (en) 1984-08-23 1988-04-21 Australian Biomedical Corporation Limited Processing apparatus
DE3434931A1 (en) * 1984-09-22 1986-03-27 Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg METHOD AND DEVICE FOR MIXING A LIQUID SAMPLE TO BE ANALYZED
EP0197984B1 (en) 1984-10-01 1990-05-23 BAXTER INTERNATIONAL INC. (a Delaware corporation) Tablet dispensing
JPS61129561A (en) 1984-11-28 1986-06-17 Olympus Optical Co Ltd Electrophoresis device
US4675299A (en) 1984-12-12 1987-06-23 Becton, Dickinson And Company Self-contained reagent package device and an assay using same
US4764342A (en) 1985-02-27 1988-08-16 Fisher Scientific Company Reagent handling
US4708886A (en) 1985-02-27 1987-11-24 Fisher Scientific Company Analysis system
US5656493A (en) 1985-03-28 1997-08-12 The Perkin-Elmer Corporation System for automated performance of the polymerase chain reaction
US4692603A (en) 1985-04-01 1987-09-08 Cauzin Systems, Incorporated Optical reader for printed bit-encoded data and method of reading same
US4782221A (en) 1985-04-01 1988-11-01 Cauzin Systems, Incorporated Printed data strip including bit-encoded information and scanner control
US4678894A (en) 1985-04-18 1987-07-07 Baxter Travenol Laboratories, Inc. Sample identification system
US4706207A (en) 1985-06-24 1987-11-10 Nova Celltrak, Inc. Count accuracy control means for a blood analyses system
DE3683573D1 (en) 1985-06-26 1992-03-05 Japan Tectron Instr Corp AUTOMATIC ANALYZER.
US4643879A (en) * 1985-07-01 1987-02-17 American Hospital Supply Corporation Tower for analyzing system
DE3650054T2 (en) 1985-07-01 1995-09-07 Baxter Diagnostics Inc REAGENT DISTRIBUTOR FOR AN ANALYSIS SYSTEM.
US4681741A (en) 1985-07-01 1987-07-21 American Hospital Supply Corporation Reagent dispenser for an analyzing system
US4719087A (en) * 1985-07-01 1988-01-12 Baxter Travenol Laboratories, Inc. Tray for analyzing system
US4933147A (en) 1985-07-15 1990-06-12 Abbott Laboratories Unitized reagent containment system for clinical analyzer
US4729661A (en) * 1985-07-29 1988-03-08 Specialty Medical Industries, Inc. Asynchronous serial cuvette reader
JPH0640054B2 (en) * 1985-09-20 1994-05-25 株式会社千代田製作所 Embedding device for electron microscope specimen preparation
US4797938A (en) 1985-10-15 1989-01-10 International Business Machines Corporation Method of identifying magnetic ink (MICR) characters
US4695430A (en) 1985-10-31 1987-09-22 Bio/Data Corporation Analytical apparatus
US4754127A (en) 1985-11-15 1988-06-28 Cauzin Systems, Incorporated Method and apparatus for transforming digitally encoded data into printed data strips
US4728783A (en) 1985-11-15 1988-03-01 Cauzin Systems, Incorporated Method and apparatus for transforming digitally encoded data into printed data strips
US4678752A (en) 1985-11-18 1987-07-07 Becton, Dickinson And Company Automatic random access analyzer
JPH0652263B2 (en) * 1985-12-10 1994-07-06 株式会社日立製作所 Cell analyzer
DE3786087T2 (en) 1986-02-07 1993-09-16 Fuji Photo Film Co Ltd DEVICE FOR CHEMICAL ANALYSIS.
US4651671A (en) * 1986-02-21 1987-03-24 Pedersen Anders N Continuous feed apparatus for staining specimens carried on slides
JPH0690212B2 (en) * 1986-02-21 1994-11-14 株式会社東芝 Automatic chemical analyzer
US4815978A (en) * 1986-04-30 1989-03-28 Baxter Travenol Laboratories, Inc. Clinical analysis methods and systems
US4871682A (en) 1986-04-30 1989-10-03 Baxter Travenol Laboratories, Inc. Diluent carryover control
JPS63503245A (en) 1986-04-30 1988-11-24 バクスター、ダイアグノスチックス、インコーポレイテッド Diluent carryover control
JPS62299769A (en) 1986-06-20 1987-12-26 Fuji Photo Film Co Ltd Dispenser
US4824641A (en) * 1986-06-20 1989-04-25 Cetus Corporation Carousel and tip
JPH01500220A (en) 1986-07-01 1989-01-26 バイオテク・インストゥルメンツ・リミテッド automatic chemical analyzer
US4900513A (en) * 1986-07-11 1990-02-13 Beckman Instruments, Inc. Sample loading apparatus
US4965049A (en) 1986-07-11 1990-10-23 Beckman Instruments, Inc. Modular analyzer system
US4728959A (en) 1986-08-08 1988-03-01 Ventana Sciences Inc. Direction finding localization system
JPS6361956A (en) * 1986-09-03 1988-03-18 Fuji Photo Film Co Ltd Chemical analysis instrument
CN1014551B (en) * 1986-09-16 1991-10-30 尼泰库株式会社 Automatic analyser
GB2196116B (en) 1986-10-07 1990-08-15 Weston Terence E Apparatus for chemical analysis.
GB2196428B (en) * 1986-10-14 1990-05-23 Tiyoda Seisakusho Kk Apparatus for dyeing specimens automatically preparatory to microscopic examination
CH669266A5 (en) 1986-10-14 1989-02-28 Serono Diagnostics Ltd Automatic analysis apparatus for the determination of antibody or antigens in a biological liquid.
US4817916A (en) * 1987-03-09 1989-04-04 Jamesbury Corporation Butterfly valve
JPH087220B2 (en) 1987-03-12 1996-01-29 富士写真フイルム株式会社 Analytical method using chemical analysis slide
US4986891A (en) * 1987-03-16 1991-01-22 Helena Laboratories Corporation Automatic electrophoresis apparatus and method
JPS63240688A (en) 1987-03-27 1988-10-06 Kajima Corp Circular code
US4855110A (en) 1987-05-06 1989-08-08 Abbott Laboratories Sample ring for clinical analyzer network
US4849177A (en) 1987-05-08 1989-07-18 Abbott Laboratories Reagent pack and carousel
US4847208A (en) 1987-07-29 1989-07-11 Bogen Steven A Apparatus for immunohistochemical staining and method of rinsing a plurality of slides
US4873877A (en) 1987-08-17 1989-10-17 Davis Meditech Precision liquid handling apparatus
US4868129A (en) 1987-08-27 1989-09-19 Biotrack Inc. Apparatus and method for dilution and mixing of liquid samples
US4854163A (en) 1987-09-28 1989-08-08 Amoco Corporation Beltless core conveyor system for wellsite analysis
GB8722902D0 (en) * 1987-09-30 1987-11-04 Shandon Southern Prod Tissue &c processing
US4794239A (en) 1987-10-13 1988-12-27 Intermec Corporation Multitrack bar code and associated decoding method
US4886590A (en) 1987-11-02 1989-12-12 Man-Gill Chemical Company Chemical process control system
EP0315757A3 (en) * 1987-11-12 1991-03-06 Oerlikon-Contraves AG Method and apparatus for storing and mixing blood samples
US5051238A (en) 1987-11-20 1991-09-24 Hitachi, Ltd. Automatic analyzing system
US4924078A (en) * 1987-11-25 1990-05-08 Sant Anselmo Carl Identification symbol, system and method
US4935875A (en) 1987-12-02 1990-06-19 Data Chem, Inc. Chemical analyzer
JPH076998B2 (en) 1987-12-04 1995-01-30 富士写真フイルム株式会社 Automatic dispenser and spotting method
JPH01187461A (en) 1988-01-22 1989-07-26 Toshiba Corp Automatic chemical analyzer
JPH01126474U (en) 1988-02-22 1989-08-29
US4795710A (en) * 1988-02-26 1989-01-03 Eastman Kodak Company Mounting of analyzer sample tray
US5681543A (en) 1988-02-29 1997-10-28 Shering Aktiengesellschaft Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI
IE64511B1 (en) 1988-03-11 1995-08-09 Takeda Chemical Industries Ltd Automated synthesizing apparatus
US5104527A (en) * 1988-03-24 1992-04-14 Ashland Oil, Inc. Automatic total reducers monitoring and adjustment system using titration
US4896029A (en) * 1988-04-08 1990-01-23 United Parcel Service Of America, Inc. Polygonal information encoding article, process and system
US4874936A (en) 1988-04-08 1989-10-17 United Parcel Service Of America, Inc. Hexagonal, information encoding article, process and system
GB2216259A (en) 1988-03-31 1989-10-04 Microvol Ltd Dispenser for chemical analysis carrying a code
US5544650A (en) 1988-04-08 1996-08-13 Neuromedical Systems, Inc. Automated specimen classification system and method
US4998010A (en) * 1988-04-08 1991-03-05 United Parcel Service Of America, Inc. Polygonal information encoding article, process and system
US4939674A (en) 1988-04-22 1990-07-03 Engineered Data Products, Inc. Label generation apparatus
US4967606A (en) 1988-04-29 1990-11-06 Caveo Scientific Instruments, Inc. Method and apparatus for pipetting liquids
US4939354A (en) 1988-05-05 1990-07-03 Datacode International, Inc. Dynamically variable machine readable binary code and method for reading and producing thereof
US5124536A (en) 1988-05-05 1992-06-23 International Data Matrix, Inc. Dynamically variable machine readable binary code and method for reading and producing thereof
US5053609A (en) 1988-05-05 1991-10-01 International Data Matrix, Inc. Dynamically variable machine readable binary code and method for reading and producing thereof
GB2218514B (en) 1988-05-12 1991-12-11 Gen Motors Corp Process evaluation by isotope enrichment
GB8816982D0 (en) 1988-07-16 1988-08-17 Probus Biomedical Ltd Bio-fluid assay apparatus
US5229074A (en) 1988-07-25 1993-07-20 Precision Systems, Inc. Automatic multiple-sample multiple-reagent chemical analyzer
US5597733A (en) * 1988-07-25 1997-01-28 Precision Systems, Inc. Automatic multiple-sample multiple-reagent dispensing method in chemical analyzer
US5382511A (en) * 1988-08-02 1995-01-17 Gene Tec Corporation Method for studying nucleic acids within immobilized specimens
US5281516A (en) * 1988-08-02 1994-01-25 Gene Tec Corporation Temperature control apparatus and method
ATE134040T1 (en) * 1988-08-02 1996-02-15 Abbott Lab METHOD AND DEVICE FOR GENERATING CALIBRATION DATA FOR ANALYSIS
JP2848411B2 (en) * 1988-08-18 1999-01-20 サイオス インコーポレイテッド Atrial natriuretic peptide clearance inhibitor
US5031797A (en) 1988-11-18 1991-07-16 Beckman Instruments, Inc. Reagent storage and delivery system
US5439826A (en) 1988-12-02 1995-08-08 Bio-Tek Instruments, Inc. Method of distinguishing among strips for different assays in an automated instrument
US5059393A (en) 1989-01-05 1991-10-22 Eastman Kodak Company Analysis slide positioning apparatus and method for a chemical analyzer
US5106583A (en) * 1989-03-08 1992-04-21 Applied Biosystems, Inc. Automated protein hydrolysis system
US5180606A (en) * 1989-05-09 1993-01-19 Wescor, Inc. Apparatus for applying a controlled amount of reagent to a microscope slide or the like
US5695739A (en) 1989-06-30 1997-12-09 Schering Aktiengesellschaft Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
US4943415A (en) 1989-07-14 1990-07-24 Eastman Kodak Company Grooved cover for test elements
US5209903A (en) 1989-09-06 1993-05-11 Toa Medical Electronics, Co., Ltd. Synthetic apparatus for inspection of blood
US5346672A (en) 1989-11-17 1994-09-13 Gene Tec Corporation Devices for containing biological specimens for thermal processing
DE3938992A1 (en) 1989-11-21 1991-05-23 Schering Ag Cascade polymer-bound complex formers, their complexes and conjugates, process for their preparation and pharmaceutical compositions containing them
US5250262A (en) 1989-11-22 1993-10-05 Vettest S.A. Chemical analyzer
US5646046A (en) 1989-12-01 1997-07-08 Akzo Nobel N.V. Method and instrument for automatically performing analysis relating to thrombosis and hemostasis
GB9020352D0 (en) 1990-09-18 1990-10-31 Anagen Ltd Assay or reaction apparatus
JPH03209163A (en) 1990-01-11 1991-09-12 Chiyoda Seisakusho:Kk Method and device for extending chromosome on slide glass
US5355304A (en) 1990-01-30 1994-10-11 Demoranville Victoria E Clinical laboratory work-flow system which semi-automates validated immunoassay and electrophoresis protocols
ES2085471T3 (en) 1990-03-02 1996-06-01 Ventana Med Syst Inc PERFECTED BIOLOGICAL REACTION PLATFORM.
US5595707A (en) * 1990-03-02 1997-01-21 Ventana Medical Systems, Inc. Automated biological reaction apparatus
US6472217B1 (en) 1990-03-02 2002-10-29 Ventana Medical Systems, Inc. Slide aqueous volume controlling apparatus
US5225325A (en) 1990-03-02 1993-07-06 Ventana Medical Systems, Inc. Immunohistochemical staining method and reagents therefor
US5075079A (en) 1990-05-21 1991-12-24 Technicon Instruments Corporation Slide analysis system
AU644876B2 (en) 1990-07-18 1993-12-23 Vision Instruments Limited Automatic tissue staining for immunohistochemistry
US5425918A (en) 1990-07-18 1995-06-20 Australian Biomedical Corporation Apparatus for automatic tissue staining for immunohistochemistry
EP0539379A4 (en) 1990-07-18 1993-06-02 Australian Biomedical Corporation Limited Automatic tissue staining for immunohistochemistry
US5118369A (en) 1990-08-23 1992-06-02 Colorcode Unlimited Corporation Microlabelling system and process for making microlabels
US5350697A (en) 1990-08-28 1994-09-27 Akzo N.V. Scattered light detection apparatus
US5920488A (en) * 1990-10-01 1999-07-06 American Auto-Matrix, Inc. Method and system for maintaining a desired air flow through a fume hood
US5428740A (en) 1990-10-18 1995-06-27 Ventana Systems, Inc. Applying successive data group operations to an active data group
DE4041905A1 (en) * 1990-12-27 1992-07-02 Boehringer Mannheim Gmbh TEST CARRIER ANALYSIS SYSTEM
US6498037B1 (en) 1991-03-04 2002-12-24 Bayer Corporation Method of handling reagents in a random access protocol
CA2384523C (en) * 1991-03-04 2007-01-09 Bayer Corporation Automated analyzer
SE9100661L (en) 1991-03-06 1992-09-07 Varta Batteri Ab PROCEDURES FOR REMOVING DEFECTS IN A SAFETY LAYER
DE4212821C2 (en) * 1991-04-19 1994-07-28 Olympus Optical Co Device for removing a closure from the opening of a container and for removing liquid contents
US5202552A (en) 1991-04-22 1993-04-13 Macmillan Bloedel Limited Data with perimeter identification tag
DE4115789A1 (en) * 1991-05-10 1992-11-12 Schering Ag MACROCYCLIC POLYMER COMPLEX IMAGERS, THEIR COMPLEXES, METHOD FOR THEIR PRODUCTION AND THE PHARMACEUTICAL AGENTS CONTAINING THEM
DE4117833C2 (en) * 1991-05-29 1993-10-07 Medite Ges Fuer Medizintechnik Method and device for staining histological specimens arranged on slides
US5576215A (en) 1991-06-03 1996-11-19 Abbott Laboratories Adaptive scheduling system and method for operating a biological sample analyzer with variable interval periods
US5282149A (en) * 1991-06-03 1994-01-25 Abbott Laboratories Adaptive scheduling system and method for a biological analyzer with reproducible operation time periods
US5289385A (en) * 1991-06-03 1994-02-22 Abbott Laboratories Adaptive scheduling system and method for operating a biological sample analyzer with variable rinsing
JPH0510958A (en) * 1991-07-02 1993-01-19 Olympus Optical Co Ltd Analysis device
WO1993003347A1 (en) 1991-07-26 1993-02-18 Cirrus Diagnostics, Inc. Automated immunoassay analyzer
US5366896A (en) 1991-07-30 1994-11-22 University Of Virginia Alumni Patents Foundation Robotically operated laboratory system
US5696887A (en) 1991-08-05 1997-12-09 Biotek Solutions, Incorporated Automated tissue assay using standardized chemicals and packages
US5355439A (en) 1991-08-05 1994-10-11 Bio Tek Instruments Method and apparatus for automated tissue assay
US5232664A (en) 1991-09-18 1993-08-03 Ventana Medical Systems, Inc. Liquid dispenser
US5184834A (en) * 1991-10-01 1993-02-09 Yu Chung Hsiung Skate shoe having an adjustable plate mounted thereto
US5338356A (en) 1991-10-29 1994-08-16 Mitsubishi Materials Corporation Calcium phosphate granular cement and method for producing same
US5245606A (en) * 1992-01-02 1993-09-14 National Semiconductor Corporation Computer network bridge circuit
US5578452A (en) 1992-01-16 1996-11-26 Biogenex Laboratories Enhancement of immunochemical staining in aldehyde-fixed tissues
US5369261A (en) 1992-02-12 1994-11-29 Shamir; Harry Multi-color information encoding system
JP3382632B2 (en) 1992-03-13 2003-03-04 オリンパス光学工業株式会社 Method for measuring biological substance and reaction vessel used for the method
DE69333230T2 (en) 1992-03-27 2004-08-05 Abbott Laboratories, Abbott Park AUTOMATIC ANALYSIS SYSTEM WITH PERMANENT AND OPTIONAL ACCESS AND COMPONENTS FOR IT
US5646049A (en) * 1992-03-27 1997-07-08 Abbott Laboratories Scheduling operation of an automated analytical system
JP3320444B2 (en) 1992-04-06 2002-09-03 株式会社千代田製作所 Nozzle cleaning equipment for dyeing equipment
US5331176A (en) 1992-04-10 1994-07-19 Veritec Inc. Hand held two dimensional symbol reader with a symbol illumination window
JPH05288756A (en) 1992-04-13 1993-11-02 Hitachi Ltd Automatic analyzer and automatic analyzing system
JP3193443B2 (en) 1992-04-24 2001-07-30 オリンパス光学工業株式会社 Automatic analyzer
DE4313807C2 (en) 1992-04-28 1995-03-09 Olympus Optical Co Reagent container system for the immunological analysis of a sample in an automatic analyzer
US5947167A (en) 1992-05-11 1999-09-07 Cytologix Corporation Dispensing assembly with interchangeable cartridge pumps
US6092695A (en) 1992-05-11 2000-07-25 Cytologix Corporation Interchangeable liquid dispensing cartridge pump
US5645114A (en) 1992-05-11 1997-07-08 Cytologix Corporation Dispensing assembly with interchangeable cartridge pumps
US6180061B1 (en) * 1992-05-11 2001-01-30 Cytologix Corporation Moving platform slide stainer with heating elements
US5316452A (en) * 1992-05-11 1994-05-31 Gilbert Corporation Dispensing assembly with interchangeable cartridge pumps
EP0640209A4 (en) * 1992-05-13 1995-10-25 Australian Biomedical Automatic staining apparatus for slide specimens.
JP3268456B2 (en) 1992-09-04 2002-03-25 フォールト トレラント システムズ エフテーエス−コンピュータ テクニク ゲセムベーハー Communication control device and information transmission method
US5316319A (en) * 1992-09-22 1994-05-31 Rm Engineered Products, Inc. Liveload assembly for maintaining torque on bolts
US5355695A (en) 1992-11-30 1994-10-18 Mitsubishi Denki Kabushiki Kaisha Refrigeration device using hydrofluorocarbon refrigerant
US5395588A (en) * 1992-12-14 1995-03-07 Becton Dickinson And Company Control of flow cytometer having vacuum fluidics
US5439645A (en) 1993-01-25 1995-08-08 Coulter Corporation Apparatus for automatically, selectively handling multiple, randomly associated hematological samples
US5336620A (en) * 1993-01-27 1994-08-09 American Home Products Corporation Process for the production of an anticoagulant composition
IT1263831B (en) 1993-01-29 1996-09-04 Paolo Chiesi MULTI-COMPONENT INCLUSION COMPLEXES WITH HIGH SOLUBILITY CONSTITUTED BY A BASIC-TYPE DRUG, AN ACID AND A CYCLODEXTRINE
US5965454A (en) 1993-02-03 1999-10-12 Histaggen Incorporated Automated histo-cytochemistry apparatus and encapsulation system for processing biological materials
JP3129015B2 (en) 1993-02-16 2001-01-29 株式会社日立製作所 Inspection method and apparatus for dyed particles
US5365595A (en) * 1993-02-19 1994-11-15 Motorola, Inc. Sealed microphone assembly
JPH06250906A (en) * 1993-02-26 1994-09-09 Fujitsu Ltd Backup/recovery system for data developed in main storage device
JPH06249857A (en) 1993-02-26 1994-09-09 Hitachi Ltd Automatic analyzing device
US5365614A (en) 1993-03-22 1994-11-22 The Orvis Company, Inc. Sports vest
US5446652A (en) 1993-04-27 1995-08-29 Ventana Systems, Inc. Constraint knowledge in simulation modeling
US5417213A (en) 1993-06-07 1995-05-23 Prince; Martin R. Magnetic resonance arteriography with dynamic intravenous contrast agents
US5587833A (en) * 1993-07-09 1996-12-24 Compucyte Corporation Computerized microscope specimen encoder
EP0720747B1 (en) 1993-09-24 2002-07-17 Abbott Laboratories Automated continuous and random access analytical system and components thereof
US5416029A (en) 1993-09-27 1995-05-16 Shandon Inc. System for identifying tissue samples
US5439649A (en) 1993-09-29 1995-08-08 Biogenex Laboratories Automated staining apparatus
CA2132269C (en) 1993-10-12 2000-02-01 Rainer Hermann Doerrer Interactive automated cytology method and system
US5441580A (en) 1993-10-15 1995-08-15 Circle-Prosco, Inc. Hydrophilic coatings for aluminum
US5487975A (en) * 1993-11-15 1996-01-30 Ventana Medical Systems, Inc. Biotin/avidin formulation
US5552087A (en) 1993-11-15 1996-09-03 Ventana Medical Systems, Inc. High temperature evaporation inhibitor liquid
US5432056A (en) 1993-11-15 1995-07-11 Ventana Medical Systems, Inc. Bisulfite-based tissue fixative
US5733528A (en) 1993-12-03 1998-03-31 Dibra S.P.A. Paramagnetic chelates for nuclear magnetic resonance diagnosis
US6451551B1 (en) 1994-03-11 2002-09-17 Biogenex Laboratories Releasing embedding media from tissue specimens
US6632598B1 (en) 1994-03-11 2003-10-14 Biogenex Laboratories Deparaffinization compositions and methods for their use
US5930461A (en) 1994-03-24 1999-07-27 Bernstein; Steven A. Method and apparatus for automated tissue assay
US5582814A (en) 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
WO1995032305A1 (en) 1994-05-19 1995-11-30 Dako A/S Pna probes for detection of neisseria gonorrhoeae and chlamydia trachomatis
IT1269839B (en) 1994-05-26 1997-04-15 Bracco Spa CONJUGATES OF BILIARY ACIDS, THEIR DERIVATIVES WITH METALLIC COMPLEXES AND RELATED USES
US6387326B1 (en) 1994-07-19 2002-05-14 Fisher Scientific Company L.L.C. Automated slide staining system and method thereof
US5431455A (en) 1994-08-05 1995-07-11 Seely; Stanley W. Recreational vehicle sewer hose containment assembly
US5946221A (en) * 1994-09-07 1999-08-31 American Auto-Matrix, Inc. Method and system for maintaining a desired air flow through a fume hood
WO1996009598A1 (en) * 1994-09-20 1996-03-28 Neopath, Inc. Cytological slide scoring apparatus
US6097995A (en) 1994-11-30 2000-08-01 Chemmist Limited Partnership Hazardous materials and waste reduction management system
KR100235345B1 (en) 1994-12-29 1999-12-15 전주범 Moving picture estimation apparatus and method in divided region
US5578270A (en) * 1995-03-24 1996-11-26 Becton Dickinson And Company System for nucleic acid based diagnostic assay
GB9506312D0 (en) * 1995-03-28 1995-05-17 Medical Res Council Improvements in or relating to sample processing
US5676910A (en) 1995-06-07 1997-10-14 Alpha Scientific Corporation Automatic blood film preparation device
DE19525924A1 (en) 1995-07-04 1997-01-09 Schering Ag Cascade polymer complexes, processes for their preparation and pharmaceutical compositions containing them
CN1104856C (en) * 1995-07-11 2003-04-09 日商岩井株式会社 Edible prawn product
JP2901521B2 (en) 1995-07-31 1999-06-07 アロカ株式会社 Biological tissue processing equipment
US5963368A (en) 1995-09-15 1999-10-05 Accumed International, Inc. Specimen management system
WO1997011914A1 (en) 1995-09-27 1997-04-03 Technicat, Inc. Water treatment arrangement
WO1997017406A1 (en) 1995-11-06 1997-05-15 M & J Bos Consultants Pty. Ltd. Uv absorbing compositions
US5888733A (en) * 1995-11-16 1999-03-30 Dako A/S In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples
NO954650D0 (en) * 1995-11-17 1995-11-17 Torstein Ljungmann Color machine for staining tissue samples on slides
KR0168189B1 (en) 1995-12-01 1999-02-01 김광호 Control method and apparatus for recognition of robot environment
US5605444A (en) 1995-12-26 1997-02-25 Ingersoll-Dresser Pump Company Pump impeller having separate offset inlet vanes
AUPN762196A0 (en) 1996-01-17 1996-02-08 Australian Biomedical Corporation Limited Specimen preparation apparatus
US5888876A (en) * 1996-04-09 1999-03-30 Kabushiki Kaisha Toshiba Deep trench filling method using silicon film deposition and silicon migration
KR20000011069A (en) * 1996-05-09 2000-02-25 스리-디멘셔널 파마슈티컬스 인코포레이티드 Micro-plate thermal shift assay and apparatus for ligand development and multi-variable protein chemistry optimization
US6509193B1 (en) * 1996-05-20 2003-01-21 Precision System Science Co., Ltd. Method and apparatus for controlling magnetic particles by pipetting machine
DE19621179C2 (en) 1996-05-25 2000-09-07 Nonnenmacher Klaus Transport unit for samples
US5723092A (en) * 1996-06-28 1998-03-03 Dpc Cirrus Inc. Sample dilution system and dilution well insert therefor
US5885529A (en) * 1996-06-28 1999-03-23 Dpc Cirrus, Inc. Automated immunoassay analyzer
DE19633436A1 (en) 1996-08-20 1998-02-26 Boehringer Mannheim Gmbh Method for the detection of nucleic acids by determining the mass
KR19990067484A (en) * 1996-09-18 1999-08-25 이치로 세키 Chemical sample processing device
JPH1090145A (en) 1996-09-18 1998-04-10 Chiyoda Manufacturing Co Ltd Rinse method by automatic staining apparatus for microscopic sample
US5839091A (en) * 1996-10-07 1998-11-17 Lab Vision Corporation Method and apparatus for automatic tissue staining
US6735531B2 (en) 1996-10-07 2004-05-11 Lab Vision Corporation Method and apparatus for automatic tissue staining
US5945341A (en) 1996-10-21 1999-08-31 Bayer Corporation System for the optical identification of coding on a diagnostic test strip
US6110676A (en) 1996-12-04 2000-08-29 Boston Probes, Inc. Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
US5968731A (en) * 1996-12-10 1999-10-19 The Regents Of The University Of California Apparatus for automated testing of biological specimens
US6327395B1 (en) 1996-12-20 2001-12-04 Xerox Parc Glyph address carpet methods and apparatus for providing location information in a multidimensional address space
US5937110A (en) * 1996-12-20 1999-08-10 Xerox Corporation Parallel propagating embedded binary sequences for characterizing objects in N-dimensional address space
US5958341A (en) 1996-12-23 1999-09-28 American Registry Of Pathology Apparatus for efficient processing of tissue samples on slides
US5948359A (en) 1997-03-21 1999-09-07 Biogenex Laboratories Automated staining apparatus
DE19712530A1 (en) 1997-03-25 1998-10-01 Boehringer Mannheim Gmbh New monomer building blocks for labeling peptidic nucleic acids
JP3428426B2 (en) * 1997-03-26 2003-07-22 株式会社日立製作所 Sample analysis system
US5994071A (en) 1997-04-04 1999-11-30 Albany Medical College Assessment of prostate cancer
AU6898398A (en) * 1997-04-08 1998-10-30 Akzo Nobel N.V. Method and apparatus for optimizing assay sequencing on a random access clinicallaboratory instrument
US5900045A (en) * 1997-04-18 1999-05-04 Taiwan Semiconductor Manufacturing Co.Ltd. Method and apparatus for eliminating air bubbles from a liquid dispensing line
US5896486A (en) 1997-05-01 1999-04-20 Lucent Technologies Inc. Mass splice tray for optical fibers
DK0881228T3 (en) 1997-05-30 2005-12-19 Pna Diagnostics As 2- or 3-dimensional geometric structures of peptide nucleic acids
US6420916B1 (en) 1997-08-05 2002-07-16 Rockwell Collins, Inc. Phase locked loop filter utilizing a tuned filter
US6093574A (en) 1997-08-11 2000-07-25 Ventana Medical Systems Method and apparatus for rinsing a microscope slide
US6045759A (en) * 1997-08-11 2000-04-04 Ventana Medical Systems Fluid dispenser
US6192945B1 (en) * 1997-08-11 2001-02-27 Ventana Medical Systems, Inc. Fluid dispenser
US8137619B2 (en) * 1997-08-11 2012-03-20 Ventana Medical Systems, Inc. Memory management method and apparatus for automated biological reaction system
US20050135972A1 (en) * 1997-08-11 2005-06-23 Ventana Medical Systems, Inc. Method and apparatus for modifying pressure within a fluid dispenser
US20020110494A1 (en) 2000-01-14 2002-08-15 Ventana Medical Systems, Inc. Method and apparatus for modifying pressure within a fluid dispenser
US6838051B2 (en) * 1999-05-03 2005-01-04 Ljl Biosystems, Inc. Integrated sample-processing system
US6486947B2 (en) 1998-07-22 2002-11-26 Ljl Biosystems, Inc. Devices and methods for sample analysis
NO306357B1 (en) * 1997-10-16 1999-10-25 Torstein Ljungmann Color machine for preparation of tissue samples placed on slides
US6193933B1 (en) * 1997-10-27 2001-02-27 Hitachi, Ltd. Automatic analysis apparatus
US6444170B1 (en) 1997-12-17 2002-09-03 Microm Laborgeräte GmbH Apparatus for the treatment for specimens
AU1752499A (en) 1997-12-23 1999-07-19 Dako A/S Cartridge device for processing a sample mounted on a surface of a support member
US6358682B1 (en) * 1998-01-26 2002-03-19 Ventana Medical Systems, Inc. Method and kit for the prognostication of breast cancer
US6699710B1 (en) * 1998-02-25 2004-03-02 The United States Of America As Represented By The Department Of Health And Human Services Tumor tissue microarrays for rapid molecular profiling
US6183693B1 (en) * 1998-02-27 2001-02-06 Cytologix Corporation Random access slide stainer with independent slide heating regulation
US6096271A (en) 1998-02-27 2000-08-01 Cytologix Corporation Random access slide stainer with liquid waste segregation
US6248590B1 (en) 1998-02-27 2001-06-19 Cytomation, Inc. Method and apparatus for flow cytometry
EP1073892B1 (en) 1998-02-27 2010-11-24 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US6582962B1 (en) * 1998-02-27 2003-06-24 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US6855559B1 (en) * 1998-09-03 2005-02-15 Ventana Medical Systems, Inc. Removal of embedding media from biological samples and cell conditioning on automated staining instruments
US6405609B1 (en) 1998-02-27 2002-06-18 Ventana Medical Systems, Inc. System and method of aspirating and dispensing reagent
US7396508B1 (en) 2000-07-12 2008-07-08 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US6495106B1 (en) 1998-03-24 2002-12-17 Biogenex Laboratories Automated staining apparatus
WO1999049295A1 (en) 1998-03-24 1999-09-30 Biogenex Laboratories Automated staining apparatus
EP1068717B1 (en) * 1998-03-31 2011-03-02 BRITISH TELECOMMUNICATIONS public limited company Computer telephony integration
US6395562B1 (en) 1998-04-22 2002-05-28 The Regents Of The University Of California Diagnostic microarray apparatus
ATE449868T1 (en) 1998-04-29 2009-12-15 Boston Probes Inc METHODS, TEST SETS AND COMPOSITIONS FOR DETECTING AND QUANTIFYING TARGET SEQUENCES
US6287772B1 (en) 1998-04-29 2001-09-11 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
DE69936237T2 (en) * 1998-05-01 2008-01-31 Gen-Probe Inc., San Diego Stirring device for the fluid content of a container
EP1078098A1 (en) 1998-05-04 2001-02-28 Dako A/S Method and probes for the detection of chromosome aberrations
WO1999058972A1 (en) * 1998-05-09 1999-11-18 Ikonisys Inc. Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis
JPH11326155A (en) 1998-05-20 1999-11-26 Hitachi Ltd Cell fractionating device
AU4696399A (en) * 1998-06-22 2000-01-10 Regents Of The University Of California, The Composition and methods for evaluating an organism's response to alcohol
AUPP441798A0 (en) 1998-06-30 1998-07-23 Australian Biomedical Corporation Limited Laboratory sampling probe positioning apparatus
WO2000002660A1 (en) 1998-07-13 2000-01-20 Biogenex Laboratories Reagent vial for automated processing apparatus
JP2002522065A (en) * 1998-08-10 2002-07-23 ジェノミック ソリューションズ インコーポレイテッド Heat and fluid circulation device for nucleic acid hybridization
US6196979B1 (en) 1998-08-24 2001-03-06 Burstein Technologies, Inc. Cassette and applicator for biological and chemical sample collection
FR2782800B1 (en) * 1998-09-01 2000-10-20 Abx Sa DEVICE FOR THE AUTOMATIC PREPARATION OF BLOOD SPREADS ON BLADES
US6414133B1 (en) 1998-10-13 2002-07-02 Ventana Medical Systems, Inc. Multiple fusion probes
US6413780B1 (en) * 1998-10-14 2002-07-02 Abbott Laboratories Structure and method for performing a determination of an item of interest in a sample
JP2000155796A (en) 1998-10-30 2000-06-06 Becton Dickinson & Co Management system for medical supply and sample
US6110425A (en) 1998-12-03 2000-08-29 Coulter International Corp. Blood smear slide outloader
US20010055799A1 (en) 1998-12-15 2001-12-27 David Baunoch Method and apparatus for automated reprocessing of tissue samples
US6890759B2 (en) 1998-12-30 2005-05-10 Becton, Dickinson And Company System and method for universal identification of biological samples
US6544798B1 (en) * 1999-02-26 2003-04-08 Ventana Medical Systems, Inc. Removal of embedding media from biological samples and cell conditioning on automated staining instruments
US20020017854A1 (en) 1999-03-08 2002-02-14 Paul Von Allmen Electron emissive surface and method of use
US6548822B1 (en) * 1999-12-30 2003-04-15 Curators Of University Of Missouri Method of performing analytical services
US6142292A (en) 1999-03-23 2000-11-07 Fmc Corporation Method and apparatus to prevent a bearing from rotating in a bearing housing
US20020176801A1 (en) 1999-03-23 2002-11-28 Giebeler Robert H. Fluid delivery and analysis systems
US6281004B1 (en) 1999-04-14 2001-08-28 Cytologix Corporation Quality control for cytochemical assays
DE19918442B4 (en) 1999-04-23 2005-04-14 Leica Microsystems Nussloch Gmbh Staining automat for staining objects for microscopic examination
US6192970B1 (en) 1999-04-28 2001-02-27 Rivindra V. Tilak Independently positioned graphite inserts in annular metal casting molds
ES2160486B1 (en) 1999-04-30 2002-05-16 Consejo Superior Investigacion Cell for holding of materials designated for transplants consists of a pressurized container housing the holder of the biological sample in physiological fluid
US6335208B1 (en) * 1999-05-10 2002-01-01 Intersil Americas Inc. Laser decapsulation method
WO2000077592A2 (en) 1999-06-11 2000-12-21 The Foxboro Company Control device providing a virtual machine environment and an ip network
US6104483A (en) 1999-06-18 2000-08-15 Lockheed Martin Tactical Defense Systems, Inc. Optical flow cell with references flange
AU5522500A (en) 1999-06-29 2001-01-22 Dako A/S Benzoate buffers for zone electrophoresis and immunofixation
CA2376619A1 (en) 1999-06-29 2001-01-11 Dako A/S Detection using dendrimers bearing labels and probes
US6534008B1 (en) * 1999-07-08 2003-03-18 Lee Angros In situ heat induced antigen recovery and staining apparatus and method
EP1203343A4 (en) * 1999-07-13 2006-08-23 Chromavision Med Sys Inc Automated detection of objects in a biological sample
DE19933153A1 (en) * 1999-07-20 2001-02-08 Byk Gulden Lomberg Chem Fab Device for processing analytes on solid phases
US6930292B1 (en) 1999-07-21 2005-08-16 Dako A/S Method of controlling the temperature of a specimen in or on a solid support member
US6532798B1 (en) 1999-09-16 2003-03-18 Shofner Engineering Associates, Inc. Micronaire, maturity and fineness measurements via continuous compression air flow permeability measurements
US6403036B1 (en) 1999-09-29 2002-06-11 Ventana Medical Systems, Inc. Temperature monitoring system for an automated biological reaction apparatus
US6403931B1 (en) 1999-10-07 2002-06-11 Ventana Medical Systems, Inc. Slide heater calibrator and temperature converter apparatus and method
WO2001029265A1 (en) 1999-10-15 2001-04-26 Ventana Medical Systems, Inc. Method of detecting single gene copies in-situ
ES2283347T3 (en) * 1999-10-29 2007-11-01 Cytyc Corporation APPARATUS AND PROCEDURE TO VERIFY THE LOCATION OF AREAS OF INTEREST WITHIN A SAMPLE IN AN IMAGE FORMATION SYSTEM.
FI116487B (en) 1999-11-15 2005-11-30 Thermo Electron Oy Apparatus and method for the treatment of laboratory test tubes
ATE271691T1 (en) 2000-01-12 2004-08-15 Ventana Med Syst Inc METHOD FOR DETECTING THE EFFECTIVENESS OF CANCER THERAPY
US6746851B1 (en) 2000-01-14 2004-06-08 Lab Vision Corporation Method for automated staining of specimen slides
DE10002803A1 (en) 2000-01-24 2001-08-02 Conbio Lizenzverwertungsgesell System for the internal qualitative and quantitative validation of marker indices
MXPA02007664A (en) 2000-02-08 2004-08-23 Univ Michigan Protein separation and display.
US6452672B1 (en) 2000-03-10 2002-09-17 Wyatt Technology Corporation Self cleaning optical flow cell
DE10012465A1 (en) 2000-03-15 2001-10-11 Jagenberg Papiertech Gmbh Assembly for coating the surfaces of a paper/cardboard web at the papermaking machine has a setting unit to act on the press rollers against their springs to give a low linear pressure in the press gap
WO2001068259A1 (en) 2000-03-16 2001-09-20 Biogenex Laboratories Automated specimen processing apparatus with fluid detection
US20030100043A1 (en) 2000-03-24 2003-05-29 Biogenex Laboratories, Inc. Device and methods for automated specimen processing
FR2806934B1 (en) * 2000-03-30 2003-04-18 Eisenmann France Sarl DEVICE FOR CONTROLLING A SURFACE TREATMENT INSTALLATION, PARTICULARLY FOR THE AUTOMOTIVE INDUSTRY
US6503457B1 (en) 2000-04-14 2003-01-07 Discovery Partners International, Inc. Container and method for high volume treatment of samples on solid supports
US6615763B2 (en) 2000-05-12 2003-09-09 Innovative Science Limited Printing on microscope slides and histology cassettes
WO2001087487A2 (en) 2000-05-15 2001-11-22 Tecan Trading Ag Bidirectional flow centrifugal microfluidic devices
GB0013619D0 (en) 2000-06-06 2000-07-26 Glaxo Group Ltd Sample container
US20030163031A1 (en) * 2000-06-26 2003-08-28 Adlabs, Inc. Method and system for providing centralized anatomic pathology services
US20020147512A1 (en) * 2000-07-25 2002-10-10 Affymetrix, Inc. System and method for management of microarray and laboratory information
DE10041226A1 (en) 2000-08-22 2002-03-07 Leica Microsystems Method for treatment of cytological and histological specimens, selects shortest paths for distributing specimens to group of treatment stations
DE10041229A1 (en) * 2000-08-22 2002-03-07 Leica Microsystems Handling apparatus for cytological or histological preparations has region which receives modular processing stations
DE10041231A1 (en) 2000-08-22 2002-03-07 Leica Microsystems Device for treating objects
DE10041230A1 (en) 2000-08-22 2002-03-07 Leica Microsystems Handling apparatus for cytological or histological preparations has feed stations and/or removal stations allocated to several processing stations
DE10041228B4 (en) * 2000-08-22 2019-02-14 Leica Biosystems Nussloch Gmbh Device for the treatment of cytological or histological preparations
US6735331B1 (en) * 2000-09-05 2004-05-11 Talia Technology Ltd. Method and apparatus for early detection and classification of retinal pathologies
US7011943B2 (en) 2000-09-06 2006-03-14 Transnetyx, Inc. Method for detecting a designated genetic sequence in murine genomic DNA
DE10052503A1 (en) 2000-10-23 2002-04-25 Leica Microsystems Object treatment device has insert that reduces maximum fill height of container, whereby rack for carrying objects for immersion in container matches residual volume
DE10052832A1 (en) 2000-10-24 2002-04-25 Leica Microsystems Laboratory assembly treating cytological or histological preparations has series of identical treatment stations for use as required
DE10052833A1 (en) * 2000-10-24 2002-04-25 Leica Microsystems Laboratory assembly to dye cytological or histological preparations monitors reagents over extended period
AU2002253796A1 (en) * 2000-10-30 2002-08-28 Robodesign International, Inc. High capacity microarray dispensing
US7113922B2 (en) 2000-11-02 2006-09-26 Living Naturally, Llc Electronic inventory movement and control device
US6844184B2 (en) * 2000-11-08 2005-01-18 Surface Logix, Inc. Device for arraying biomolecules and for monitoring cell motility in real-time
US20030215936A1 (en) * 2000-12-13 2003-11-20 Olli Kallioniemi High-throughput tissue microarray technology and applications
GB0030809D0 (en) 2000-12-16 2001-01-31 Schmidt Paul Sample tracking systems
JP3864193B2 (en) * 2000-12-22 2006-12-27 アークレイ株式会社 measuring device
JP4322430B2 (en) * 2001-01-29 2009-09-02 エスアイアイ・ナノテクノロジー株式会社 Differential scanning calorimeter
US6855925B2 (en) * 2001-02-14 2005-02-15 Picoliter Inc. Methods, devices, and systems using acoustic ejection for depositing fluid droplets on a sample surface for analysis
DE10115065A1 (en) 2001-03-27 2002-10-02 Leica Microsystems Method and device for printing on cassettes or slides for histological preparations
EP1248170B1 (en) * 2001-04-05 2009-09-16 INPECO IP Ltd. Method for the management of workcell systems based on an automation management system
WO2002088670A1 (en) 2001-04-30 2002-11-07 Ventana Medical Systems, Inc. Method and composition for staining microorganisms
JP3603278B2 (en) * 2001-09-06 2004-12-22 理学電機工業株式会社 X-ray fluorescence analysis system and program used therefor
DE10144042B4 (en) 2001-09-07 2006-04-13 Leica Microsystems Nussloch Gmbh Processing device for dyeing and covering slides
JP5193408B2 (en) * 2001-09-13 2013-05-08 ベックマン コールター, インコーポレイテッド Automatic analyzer
AU2002328229A1 (en) 2001-09-21 2003-04-01 Mds Proteomics Inc. Yeast proteome analysis
EP2466313B1 (en) 2001-10-01 2016-03-30 Leica Biosystems Melbourne Pty Ltd Apparatus for histological tissue specimen treatment
US20030099580A1 (en) 2001-10-19 2003-05-29 Monogen, Inc. Universal microscope slide cassette
KR100458148B1 (en) * 2001-10-29 2004-11-26 포라 가세이 고교 가부시키가이샤 A skin analysis system
US7270785B1 (en) 2001-11-02 2007-09-18 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having fixed slide platforms
DE10154843A1 (en) 2001-11-08 2003-05-28 Microm Int Gmbh Method and device for labeling slides for microtomized tissue samples and their processing
DE20118271U1 (en) * 2001-11-09 2002-02-14 Rehau Ag & Co Windshield wiper fluid reservoir
AU2002361618A1 (en) 2001-11-13 2003-05-26 Chromavision Medical Systems, Inc. A system for tracking biological samples
US6998270B2 (en) 2001-11-26 2006-02-14 Lab Vision Corporation Automated tissue staining system and reagent container
US20040033163A1 (en) * 2001-11-26 2004-02-19 Lab Vision Corporation Automated tissue staining system and reagent container
US7005110B2 (en) 2001-12-20 2006-02-28 Ventana Medical Systems, Inc. Method and apparatus for preparing tissue samples for sectioning
US8449822B2 (en) * 2002-01-18 2013-05-28 Sysmex Corporation Smear preparing apparatuses and methods of preparing sample smears
US7378058B2 (en) * 2002-01-30 2008-05-27 Ventana Medical Systems, Inc. Method and apparatus for modifying pressure within a fluid dispenser
US7468161B2 (en) * 2002-04-15 2008-12-23 Ventana Medical Systems, Inc. Automated high volume slide processing system
ES2424988T3 (en) * 2002-04-15 2013-10-10 Ventana Medical Systems, Inc. Automated slide plate coloring system with high production speed
US20030200111A1 (en) 2002-04-19 2003-10-23 Salim Damji Process for determining optimal packaging and shipping of goods
EP1499872B1 (en) 2002-04-26 2015-11-18 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having fixed slide platforms
US20030215357A1 (en) 2002-05-13 2003-11-20 Nigel Malterer Automated processing system and method of using same
WO2003106157A2 (en) 2002-06-14 2003-12-24 Chromavision Medical Systems, Inc. Automated slide staining apparatus
EP1514089B1 (en) 2002-06-20 2014-05-14 Leica Biosystems Melbourne Pty Ltd Biological reaction apparatus with draining mechanism
DE20210451U1 (en) * 2002-07-05 2002-10-17 Leica Microsystems Drive for a device for coloring objects
EP1313262A1 (en) * 2002-07-30 2003-05-21 Agilent Technologies Inc. a Delaware Corporation Integrating different naming conventions into a network management system
US6832904B2 (en) 2002-08-15 2004-12-21 Wellman, Inc. Apparatus for cooling and finishing melt-spun filaments
US6872901B2 (en) * 2002-11-21 2005-03-29 Exon Science Inc. Automatic actuation of device according to UV intensity
US7135992B2 (en) 2002-12-17 2006-11-14 Evolution Robotics, Inc. Systems and methods for using multiple hypotheses in a visual simultaneous localization and mapping system
US20040122708A1 (en) 2002-12-18 2004-06-24 Avinash Gopal B. Medical data analysis method and apparatus incorporating in vitro test data
US7850912B2 (en) 2003-05-14 2010-12-14 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7648678B2 (en) * 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
CA2507995A1 (en) 2002-12-20 2004-07-08 Dakocytomation Denmark A/S An automated sample processing apparatus and a method of automated treating of samples and use of such apparatus
US7875245B2 (en) 2003-05-14 2011-01-25 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7584019B2 (en) 2003-12-15 2009-09-01 Dako Denmark A/S Systems and methods for the automated pre-treatment and processing of biological samples
AU2003900780A0 (en) 2003-02-21 2003-03-13 Vision Biosystems Limited Analysis system and procedure
AU2003900810A0 (en) 2003-02-24 2003-03-13 Vision Biosystems Limited Method of scheduling
JP2004325117A (en) 2003-04-22 2004-11-18 Olympus Corp Liquid dispensing apparatus and method of washing dispensing head
US8283176B2 (en) * 2004-06-29 2012-10-09 Dako Denmark A/S Method of pre-treatment and staining of a biological sample and device for support of a biological sample and methods of using such device
US20060073074A1 (en) * 2004-10-06 2006-04-06 Lars Winther Enhanced sample processing system and methods of biological slide processing
WO2004114081A2 (en) 2003-06-20 2004-12-29 Paradigm Genetics, Inc. Methods and systems for creation of a coherence database
US7860727B2 (en) 2003-07-17 2010-12-28 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
US8719053B2 (en) * 2003-07-17 2014-05-06 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
US9518899B2 (en) * 2003-08-11 2016-12-13 Sakura Finetek U.S.A., Inc. Automated reagent dispensing system and method of operation
EP2489434B1 (en) * 2003-09-09 2016-04-27 BioGenex Laboratories Sample processing system
DE10342264C5 (en) 2003-09-12 2012-10-31 Leica Biosystems Nussloch Gmbh System for uniquely assigning histological cassettes and slides
EP1673608A4 (en) 2003-09-29 2008-05-07 Vision Biosystems Ltd System and method for histological tissue specimen processing
US7142852B2 (en) 2003-11-13 2006-11-28 Motorola, Inc. Method and gateway for controlling call routing
EP1733240A4 (en) 2004-03-02 2007-08-22 Dako Denmark As Reagent delivery system, dispensing device and container for a biological staining apparatus
DE202004006265U1 (en) 2004-04-21 2004-06-17 Leica Microsystems Nussloch Gmbh Microtem for the production of thin sections
JP4482371B2 (en) * 2004-05-12 2010-06-16 シスメックス株式会社 Clinical specimen processing system
JP4152351B2 (en) * 2004-06-17 2008-09-17 シスメックス株式会社 Clinical specimen processing apparatus and clinical specimen processing system
EP1612536A3 (en) * 2004-06-29 2007-03-07 Sysmex Corporation Clinical specimen processsing apparatus
US7867443B2 (en) * 2004-07-23 2011-01-11 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
CN1753432A (en) * 2004-09-22 2006-03-29 国际商业机器公司 Method and system for implementing personalized incoming notifying and terminal apparatus
US20060084088A1 (en) 2004-10-15 2006-04-20 Schultz Emily R Tracking biological samples and their processing history
JP4840763B2 (en) * 2006-01-18 2011-12-21 セイコーインスツル株式会社 Automatic thin section preparation apparatus and automatic thin section preparation apparatus
WO2008055096A2 (en) * 2006-10-30 2008-05-08 Ventana Medical Systems, Inc. Thin film apparatus and method

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