CA2518992A1 - Air sampling apparatus with related sensing and analysis mechanism - Google Patents

Air sampling apparatus with related sensing and analysis mechanism Download PDF

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Publication number
CA2518992A1
CA2518992A1 CA002518992A CA2518992A CA2518992A1 CA 2518992 A1 CA2518992 A1 CA 2518992A1 CA 002518992 A CA002518992 A CA 002518992A CA 2518992 A CA2518992 A CA 2518992A CA 2518992 A1 CA2518992 A1 CA 2518992A1
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CA
Canada
Prior art keywords
bag
sampling apparatus
air sampling
breath
sensing mechanism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002518992A
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French (fr)
Inventor
Steven D. Hamilton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
QUINTRON INSTRUMENT Co
Original Assignee
QUINTRON INSTRUMENT Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by QUINTRON INSTRUMENT Co filed Critical QUINTRON INSTRUMENT Co
Publication of CA2518992A1 publication Critical patent/CA2518992A1/en
Abandoned legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/08Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/097Devices for facilitating collection of breath or for directing breath into or through measuring devices

Abstract

An air sampling apparatus is disclosed, including a bag for containing air and a sensing mechanism coupled to said bag. The self contained sampling and sensing mechanism can be used for visual or other detection of targeted analytes within a breath.

Description

Atty. DoCl~et Np.- '7165_18676 .. 1 _ Patent AIR SANPT~T13G AP~'ARATZTS WITS REhATED SENSING AND

Background of the Iziventian S Thia ir~.ventiorr relates to t~lze field o:~
samplixxg azx from the lungs a.nd spec~,fically t~~ the field of obtaining a sample of a person's air,including alveolar air from the alveoli of the luxlgs of a person.
Air Exam the lungs of a person, eon. be used for many different types of testing that would othexvrise require the person to undexga an invasive procedure. For example, alveolar air can be analyzed for, but not limited to, the noninvasive diagnosis of a w:.de variety of conditions ineludiz~g the noninvasive diagnorxs of stomach infections related to a high incidence of uleere, er~zymatic deficiencies, anal metabolic condit:.ons and/or abnormalities. Crucial to az~y such testing is the ability to get an accurate sample containing a sufficient volume of alx representative of true alveolar air, necessary far specific testing.
A simple to use, inexpensi~re, and user-friendly apparatus is desixed to collect and store human breath samples_ Siumma,ry of the Zi7.ven.tioa The present invention irf.corporates one ar more Atty. Doclcct No.: 7165.18676 sensing and analy9is mechanisms by coupling said mechanisms to a breath coJ.leotivn apparatus, such as a bag. One exemplary bag is described in commonly owned U.S. Patent 6,468,477.
Preferred sensing and analysis mechanisms are vapor-selective detectors or ~tartificial noses" that are typically based upc~z~. the production of an interpretable signal or display upon. exposure to a vapcr emitt~lng substaxxae or odorant (hereinafter sometimes referred to as ara "analyte") within a humanE brEath, More specifically, typical artificial noses are based upon seleoti.ve chemical binding or an interface between a deteCti~g compound of the artificial nose and an ana.lyte or odorant, and then transforming that chemi~~a1 binding inLO a signal or c~l.isplay, i.e., signal transduotion.
,brief description of the Drawriags Fig. 1 is a'sida view of a breath collectioz2 bag of tkxe present invention, ooupJ.ed to a sens~.ng mechaxxxsm for solar analysis.
Fig. zA is a aide view, with portions Gut away, of an alternate embodiment of a breath colleGtioI1 bag, coupled to a sensing mecY~anism for color analysis.
Fig. 2~ is'a cross sectional view of a breath collection bag of the present invention ahowr.~ in F'ig. 1, ~5 coupled to a sensing mechanism for color ana.lysxs.
Fig. 3 is a side view of a breath collection bag of the present invention, coupled to a sensing mechanism far Color analysis, said bag havi~xg a preferred forced air path to move breath across rk~.e sensing 3b mechanism.
Fig. 4 is a side view of an alternate embodiment of a breath col~.eetion baq df the present invention, coupled to a sensing mechanism for Color analysis, said bag Having a preferred forced air path to 35 move breath across the sensix~g mechanism.

Atty. ypekeL No.: 7165_18676 Descriptioa of the Preferred Embvdimerit Although the di~;closux~e hereof is detailed and e~tact to enable those skilled in the art to practice the invention, the physical embodimez~,ts herein disclosed b merely exemplify the invention which may be embodied in other specific Structures. While the preferred embodiment has been described, the details may be changed without departing from the invention, which is defined by the claims.
Referring now to Fig. z, a side view of a bzeath collection bag 10 of the presez~.t invention, coupled to a sensing mechanism for color analysis is shown. A breath intake structure 100 is provided for a patient to breathe in, so that the breath can be exposed to the sensing mechanism 200. The sensing mechanism 200 shc~u7.d be at least partially exposed to the breath of the patient, so that the breath can be analysed.., .
It is preferab7.e, though not repaired, ,that the bag ~.0 i9 of two ply construction, the two plies sealed together. Of course, more ox less pliES may be used in the bag construction. The bag structure 10 is preferably expsndalale, arid constructed of a supp3.e, inert, and airtight material. oz~,e such supple and airtight material that performs suitably i9 thin polyester film, but foil laminate and a variety of other materials cou~.d, also perform suitably. It should be easily recognisable to one skilled inn, the art that any number of matarialas other than foil lam~.nate can be used, for the bag structure 10. Other examples of materia7.s 3~ that could be used for constructing the present invention include for illustration, but not by way of lim~.tation:
Ted~,ar~, Saranexe, Saran°°, and TefJ.vn~. Those sk~,lled in the ar_t will appreciate that the material can vary widely based on the characteristics of the gases desired to be sampled_ The materials chosen should be inert and Atty. DocYet loo.: 'T165.I867B
exhibit relative impermeability to the gases desired to sample, and arty materials chosen that are relatively permeable to the gases desired to sample would not be preferred.
A preferred sensing mechanism 200 is an array-based vapor-sensing device, available frr~rn ChemSensing of ~lorthbrook, rL. This sensing mechanism is us~:d to detept and differentiate between chemically diverss~ a.z~alytes, based pt~ dross-responsive sensor elements to mimic 'the 1D mammalian olfactory t~ystem~ by pradvcing composite respC~r~ses unigue to each bdorant, such as eole~r response, as described in Ftakr~w, N. A_; suslick, K. ~, "A
CQlorimetric Sensor Array for odour Visualization"
Nature, 2000, X06, 710-714; Suslick, 'K. S.; Rakaw, N. A.
"GolCrimetric Artificial I~Tose Iiaviz~g an Array of Dyes and Method for Artificial plfaction", incorfsorated by reference. An array of dot shaped sensor elements 200a can detect a variety of substances ~ri.thin the breath of a human_ there is desc~eibed an optical chemical sensing method that utilizes the color change induced in an array of metalloparphyrin dyes upon ligand binding while minimising the need for extensive signal transduetion hardware_ The chemoselective response of a library of immobilized ~~apor~sensing metalloporphyrin dares permits the visual identification of a wide range of ligating (alcohols, am~.x~es, ethers, ghosphines, phosphitas, thioethera and thipls) and even weakly Ligating (arenes, halocarbons and ketones7 vepars.
One preferred sensing mechanism 200 comprises a device fQx detecting an analyte comprising ,an analyte specific compound that binds to the analyte and produces a detectable compound in combination with ~a given substrate, said detectable compound producing a resgonse when exposed to at least two dyes, th.e response being stronger and more distWict than a xesponse of the arm.lyte ntt~_ noex~e r~o.: mss.ieszs -w~7;ex~ exposed to the at least two dyes , such a,,. disclosed ~.x~ U.S. Patent Appliaatian 2DD4D~.5'72t3i to Hulkower, inGOrporated herein by referanee_ Far example, one or more pax~phyzin dyes 117. its 5 metalated form (e_g_ , metal7.oporphyrin) or ria~,-~ttetalated form (e_g_. free-base pozZalayrin) can be uses to detect the en~ymatically generated. volatile Gotlipotxrids and the porphyrin dye can 1~e used alone or ae a Gompt~rierit in an array with other chemical dyeas, such as Etrox~sted e'tCid '10 base dyes, Lewis acid-base dyes, zzu~,tterioriic solvatochromic~ dyes, and other ehemorasporisive dyes.
Those skilled in tk~e art will recogri.~.ze that any suitable method may be used. to detect and quantitate a dye color charge corresponding to~the presence of the enzymatically 7.5 generated volatile compound, such as the unas:~isted eye, spectrophotometry and fluorescence detection. or ether readexs or sensors (not shown).
A human breatlx, after exposure to 1=he sensing mechanism 2fl0, will provide a change in co7.or from a 2~ baseline color pattern, providing a unique color fingerprint at perceived and targetec7 a.nalyte eoncentratiorzs . The sensing meohanism 2nt~ campriaea a housing 2D2, preferably with a clear cover tea a7.law easy perception of color change. uhe housing 2n2 holds the ~5 array 200a, and ports P (see Fig. 2a) allow air into the=
housing 20~ for exposure to the array ~DDa.
The embodiment described in Fig. z is r_ef_er_red to as an ambient bag 10/sensor 20o system heaaasp the air is allowed to lae exposed to the sensor 200 without a 30 mechanism for moving the brQath mcaz-e ~.t:ic:kly across the sensor 200. Dynamic systems will 1aQ de$cxibed. later, where the breath is actively passed across the sensor 200 to improve the speed that the serisor 200 can have enough breath past it to provide an accurate reading.
35 The preferred sensing mechanism 2C~0 is shown Atty_ L4C7G~t I30.: 7165_18676 as a preferred embodiment, others may do. The benefit of the sensing mechanism ~p0 coupled with the back 10 is that the breath need Trot be transferred from the bag 10 to the testing medium - w1-rich could decrease test ~~,ccuracy bar introduction to contaminants, and also this assembly creates an easier test. tn administer.
Fig. 2A is a' side view, with portions cut a~iay, ofi ari alternate embodiment of a dynamic aystcm breath collect~,on, bag 10, coupled to a sensing mechanism 1Q 2pp fnr color analyeia is shown.
In this dylrsmio embodiment, the bag 1~o is provided with a seam or partition 12 between two ports P.
A user can then force air past the sensor array YOOa by squaesing one Bide of the bag Z0, alterxiating with the nth.er side of the bag 10,~in bellows like fa;~hion. The air flow path would 'thus be from the left side of the bag 10 to the right, right to ~.eft and so on. In this embodiment, the housing 202 is sealed within a side seam of the bag 10, as opposed to the hous~.ng 202 within the I~.m~.ts of a facE of the bag as shown in Fig. 1. A side seam or seam coupling is referred to herein as a sensing mechanism that is coupled between two seams of the bag 1o_ The housing 202 aaz~ be sealed to the bag by such techniques as heat ax adhesive.
rig. ~8 is a Gross sectior~al view of a breath coll~rctzon bag of the present iriver~.tion shown iz~ 7Fig. 1.
zn this embodiment, the housing 202 of the .~ezxsing meahana.s~m 20o ~,s coupled with the ba.g 18 in what is 3d called face coupling ox a face. Face coupling is referred to herein as a sens~.zlg mechanism that is coupled with one or more facesc of the bag 10.
fig. 3 is a side view of a dynamic seam coupling breath collection bag 10 of the present invention. In this embodiment, the air intake structure ratty. T~ocxec No.: ~m65.~.8676 100 is provided on one side of a partition 12.
p-reLerred forced air path is provided by the partition I2, which divides right anal left sides of the bag 10. A
one way valve 2a to move breath across i=he ser~sing mechanism 200_ A circular flp4r path is created in this embodiment _ Tkr,e partition 12 could be pr~5~rided w~ tb.
xanes of weakness 12' across an inlet of tha va7.ve 20, and oz~.e of the ports P such that a single breath would be captured on one portion. of the bag 10. By ac,~ueezing the bag ~Q, the zones of weakness 12' would b~= .ruptured, allowing manipulation of the bag 10 and ai.r could be circuJ.ated across the circular flow path des,:xi_bed.
Fig. ~ is a side view of an. alternate embodimexit of a seam sealed dynamics breath collection bag 1p of the present invention. 3:n this embodiment, a fight/left alternating flow path a_s created about the two sides of partition 12.
The foregoing is cor~sidered as illustrative only of the principles of the inventa,an. Furthermore, ~sinCe ritxmerous modifications and changes will reada.ly occur to those skilled in the art, it is not cYesired to limit the invention to the exact conetructiozz and operation shown and described. Ti~hile the preferred embodiment has keen described, the details ma~~ be changed without depa.rti.ng from the invent2vr~, which ~.s defined by the claims.

Claims (10)

1. ~An air sampling apparatus comprising:
a bag for containing air;
a sensing mechanism coupled to said bag, said sensing mechanism having a housing coupled to said bag.
2. ~An air sampling apparatus according to claim 1, said housing and said bag coupled by a side seam.
3. ~An air sampling apparatus according to claim 1, said housing having at least two ports, said bag having a partition between said ports.
4. ~An air sampling apparatus according to claim 2, said housing having at least two ports, said bag having a partition between, said ports; said partition having at least one zone of weakness.
5. ~An air sampling apparatus according to claim 2, said housing having at least two ports, said bag having a partition between said ports, said partition defining two interior portions of said bag, said interior portions coupled by a valve.
6. ~An air sampling apparatus according to claim 1, said housing and said bag coupled by a face coupling.
7. ~An air sampling apparatus according to claim 1, said apparatus comprising an ambient system.
8. ~An air sampling apparatus according to claim 1, said apparatus comprising a dynamic system.
9. ~An air sampling apparatus according to claim 1, wherein said sensing mechanism comprises a device for detecting an analyte comprising an analyte-specific compound that binds to the analyze and produces a detectable compound in combination with a given substrate, said detectable compound producing a response when exposed to at least two dyes, the response being stronger and more distinct than a response of the analyte when exposed to the at least two dyes.
10. A method of sampling a breath, said method comprising the steps of:
providing a bag with a breath intake structure and a sensing mechanism;
breathing into said bag;
allowing said breath to contact said sensing mechanism;
analyzing a response of said sensing mechanism to said breath.
CA002518992A 2004-09-10 2005-09-09 Air sampling apparatus with related sensing and analysis mechanism Abandoned CA2518992A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/938,859 2004-09-10
US10/938,859 US20060058696A1 (en) 2004-09-10 2004-09-10 Air sampling apparatus with related sensing and analysis mechanism

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ITMI20111634A1 (en) * 2011-09-09 2013-03-10 Frattini Paolo Giuseppe Gobbi FLEXIBLE BAG WITH TWO COMPARTMENTS FOR THE COLLECTION OF FIATO SAMPLES SUITABLE FOR EXAMINATION OF FOOD INTOLERANCES.

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