CA2526362A1 - Ophthalmic drug delivery system - Google Patents

Ophthalmic drug delivery system Download PDF

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Publication number
CA2526362A1
CA2526362A1 CA002526362A CA2526362A CA2526362A1 CA 2526362 A1 CA2526362 A1 CA 2526362A1 CA 002526362 A CA002526362 A CA 002526362A CA 2526362 A CA2526362 A CA 2526362A CA 2526362 A1 CA2526362 A1 CA 2526362A1
Authority
CA
Canada
Prior art keywords
fluid
atomizer according
discharge plate
reservoir
propulsion means
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002526362A
Other languages
French (fr)
Other versions
CA2526362C (en
Inventor
James F. Collins
Randal B. Chinnock
Jeffrey Melanson
Joseph Howard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2526362A1 publication Critical patent/CA2526362A1/en
Application granted granted Critical
Publication of CA2526362C publication Critical patent/CA2526362C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0638—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced by discharging the liquid or other fluent material through a plate comprising a plurality of orifices
    • B05B17/0646—Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0623—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers coupled with a vibrating horn
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0653—Details
    • B05B17/0676—Feeding means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A61M11/065—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type using steam as driving gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/59—Aesthetic features, e.g. distraction means to prevent fears of child patients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0612—Eyes

Abstract

A fluid atomizer is disclosed. The fluid atomizer comprises a body having a proximal end and a distal end. A removable reservoir containing a fluid disposed therein is connected to the body. A discharge plate is disposed at the distal end, wherein the discharge plate includes a plurality of openings extending therethrough. An ultrasonic oscillator is disposed in the body for transmitting the fluid from the reservoir to the discharge plate and through the plurality of openings, wherein transmission of the fluid through the plurality of openings atomizes the fluid.

Claims (32)

1. A fluid atomizer comprising:
a body having a proximal end and a distal end;
a removable reservoir connected to the body, wherein the reservoir contains a fluid disposed therein;
a discharge plate disposed at the distal end, wherein the discharge plate includes a plurality of openings extending therethrough; and propulsion means for transmitting the fluid from the reservoir to the discharge plate and through the plurality of openings, wherein transmission of the fluid through the plurality of openings atomizes the fluid.
2. The fluid atomizer according to claim 1, further comprising means for selectively determining an amount of the fluid to be transmitted through the plurality of openings during operation of the fluid atomizer.
3. The fluid atomizer according to claim 1, wherein the body further comprises a handle having a trigger mechanism that is alternatively operable by one of a thumb of a first user wherein the distal end is pointed toward the first user and by the other of a finger of the first user wherein the distal end is pointed toward a second user.
4. The fluid atomizer according to claim 1, further comprising a heater element disposed proximate to the fluid such that the heater element heats the fluid.
5. The fluid atomizer according to claim 1, wherein the propulsion means comprises a piezoelectric device.
6. The fluid atomizer according to claim 5, wherein the piezoelectric device comprises a lumen having an elongated shape.
7. The fluid atomizer according to claim 1, wherein the wherein the plurality of openings are arranged in the discharge plate in an elongated shape.
8. The fluid atomizer according to claim 1, wherein the atomizer discharges the fluid having a velocity of between approximately 4 and 30 centimeters per second.
9. The fluid atomizer according to claim 1, wherein the atomizer discharges between approximately 2 and 20 microliters per second.
10. The fluid atomizer according to claim 9, wherein the atomizer discharges between approximately 7 and 10 microliters per second.
11. The fluid atomizer according to claim 9, wherein the atomizer operates for approximately 0.5 to 5 seconds.
12. The fluid atomizer according to claim 1, wherein the atomizer discharges the fluid having average particle sizes between approximately 0.5 and 10 microns in diameter.
13. The fluid atomizer according to claim 1, further comprising a system controller operatively connected to the propulsion means for controlling operation of the propulsion means.
14. The fluid atomizer according to claim 13, further comprising means for transmitting data between the system controller and an external device.
15. The fluid atomizer according to claim 13, further comprising means for operating the atomizer for a period in excess of five seconds.
16. The fluid atomizer according to claim 13, further comprising a low level alert operatively connected to the system controller, wherein the low level alert transmits a signal that the fluid is at a low level in the reservoir.
17. The fluid atomizer according to claim 13, further comprising means for adjusting operation of the propulsion means to adjust an amount of the fluid transmitted across the discharge plate.
18. The fluid atomizer according to claim 17, wherein the means for adjusting operation of the propulsion means are operatively connected to the system controller.
19. The fluid atomizer according to claim 1, wherein the discharge plate is releasably connected to the body.
20. The fluid atomizer according to claim 1, wherein the propulsion means comprises an operating switch operable among an off position, a first operating position, and a second operating position.
21. The fluid atomizer according to claim 20, further comprising a system controller operatively connected to the propulsion means for controlling operation of the propulsion means.
22. The fluid atomizer according to claim 21, wherein, upon engaging the operating switch in the second operating position, the system controller transmits an operating signal to the propulsion means for no more than five seconds.
23. The fluid atomizer according to claim 21 wherein, upon engaging the operating switch in the first operating position, the system controller transmits a signal to a user that the device is ready for operation.
24. The fluid atomizer according to claim 1, wherein the reservoir is tinted.
25. A fluid atomizer comprising:
a body having a proximal end and a distal end;
a removable reservoir connected to the body, wherein the reservoir contains a fluid disposed therein;
a discharge plate disposed at the distal end, wherein the discharge plate includes a plurality of openings extending therethrough;
propulsion means for transmitting the fluid from the reservoir to the discharge plate, wherein transmission of the fluid across the discharge plate atomizes the fluid; and a system controller electronically connected to the propulsion means, wherein the system controller controls operation of the propulsion means.
26. The fluid atomizer according to claim 25, further comprising a low level alert operatively connected to the system controller, wherein the low level alert transmits a signal that the fluid is at a low level in the reservoir.
27. A fluid atomizer comprising:
a body having a proximal end and a distal end;
a reservoir connected to the body, wherein the reservoir contains a fluid disposed therein;
a discharge plate disposed at the distal end, wherein the discharge plate includes a plurality of openings extending therethrough;
propulsion means for transmitting the fluid from the reservoir to the discharge plate and through the plurality of openings, wherein transmission of the fluid through the plurality of openings atomizes the fluid; and means for spacing the discharge plate a predetermined distance from a target.
28. The fluid atomizer according to claim 27, wherein the means for spacing the discharge plate comprises a spacer bar releasably connected to the body.
29. The fluid atomizer according to claim 27, wherein the means for spacing the discharge plate comprises at least one light projected onto the target.
30. The fluid atomizer according to claim 27, wherein the reservoir is removable.
31. The fluid atomizer according to claim 27, wherein the reservoir is refillable.
32. A fluid atomizer comprising:
a body having a proximal end and a distal end;
a removable reservoir connected to the body, wherein the reservoir contains a fluid disposed therein;
a discharge plate disposed at the distal end, wherein the discharge plate includes a plurality of openings extending therethrough;
propulsion means for transmitting the fluid from the reservoir to the discharge plate, wherein transmission of the fluid across the discharge plate atomizes the fluid;

a system controller electronically connected to the propulsion means, wherein the system controller controls operation of the propulsion means; and means for adjusting operation of the propulsion means to adjust an amount of the fluid transmitted across the discharge plate, wherein the means for adjusting operation of the propulsion means are operatively connected to the system controller.
CA2526362A 2003-05-20 2004-05-20 Ophthalmic drug delivery system Expired - Fee Related CA2526362C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US47188303P 2003-05-20 2003-05-20
US60/471,883 2003-05-20
US48530503P 2003-07-03 2003-07-03
US60/485,305 2003-07-03
PCT/US2004/016181 WO2004103478A1 (en) 2003-05-20 2004-05-20 Ophthalmic drug delivery system

Publications (2)

Publication Number Publication Date
CA2526362A1 true CA2526362A1 (en) 2004-12-02
CA2526362C CA2526362C (en) 2012-10-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2526362A Expired - Fee Related CA2526362C (en) 2003-05-20 2004-05-20 Ophthalmic drug delivery system

Country Status (7)

Country Link
US (3) US7883031B2 (en)
EP (1) EP1624938B1 (en)
AT (1) ATE501766T1 (en)
CA (1) CA2526362C (en)
DE (1) DE602004031829D1 (en)
HK (1) HK1086776A1 (en)
WO (1) WO2004103478A1 (en)

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