CA2530492A1 - Portable electrotherapy device for knee joint maladies - Google Patents

Portable electrotherapy device for knee joint maladies Download PDF

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Publication number
CA2530492A1
CA2530492A1 CA002530492A CA2530492A CA2530492A1 CA 2530492 A1 CA2530492 A1 CA 2530492A1 CA 002530492 A CA002530492 A CA 002530492A CA 2530492 A CA2530492 A CA 2530492A CA 2530492 A1 CA2530492 A1 CA 2530492A1
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CA
Canada
Prior art keywords
duty cycle
signal
compound electric
signals
approximately
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002530492A
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French (fr)
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CA2530492C (en
Inventor
Carl T. Brighton
Michael D. Carlozzi
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University of Pennsylvania Penn
Original Assignee
The Trustees Of The University Of Pennsylvania
Carl T. Brighton
Michael D. Carlozzi
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Application filed by The Trustees Of The University Of Pennsylvania, Carl T. Brighton, Michael D. Carlozzi filed Critical The Trustees Of The University Of Pennsylvania
Publication of CA2530492A1 publication Critical patent/CA2530492A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Abstract

A portable device for applying therapeutic electrical signals and/or electromagnetic fields to a patient's knee for the treatment of osteoarthritis and other diseases, defects and injuries. The device is operable in several modes to deliver signals to the patients knee so as to cause an electric and/or electromagnetic field to be generated that selectively up-regulates gene expression of Aggrecan and Type II Collagen while simultaneously selectively down-regulating the gene expression of metalloproteases. The device includes a signal generator that generates compound electric signals including a 60kHz sine wave having a peak to peak voltage of approximately 4.6 V to 7.6 V and a 100% duty cycle signal that is generated for approximately 30 minutes and a 50% duty cycle signal that is generated for approximately 1 hour after the 100% duty cycle signal. These compound electric signals are communicated to electrodes or coils in the proximity of a patient's knee for the generation of a specific and selective electromagnetic field that treats the diseased tissue.

Claims (18)

1. ~A device for generating specific and selective signals for application to a capacitive coupling and/or inductive coupling device for the generation of selective electric or electromagnetic fields for the treatment of defective or diseased tissue in a human knee joint, comprising:
a signal generator that generates compound electric signals that selectively up-regulate at least one of Aggrecan gene expression and Type II Collagen gene expression and selectively down-regulates metalloprotease gene expression; and means for communicating said compound electric signals to said capacitive and/or inductive coupling device.
2. ~A device as in claim 1, wherein said compound electric signals comprise a 60 kHz sine wave having a peak to peak voltage of approximately 4.6 V to 7.6 V.
3. ~A device as in claim 2, wherein said compound electric signals comprise a 100% duty cycle signal that is generated for approximately 30 minutes and a 50% duty cycle signal that is generated for approximately 1 hour after said 100%
duty cycle signal.
4. ~A device as in claim 3, wherein said signal generator further generates during a 24 hour time period at least one additional 50% duty cycle signal having a duration of approximately 1 hour.
5. ~A device as in claim 4, wherein said signal generator is selectable into at least three modes, a first mode for generating during a 24 hour time period said compound electric signal and three of said additional 50% duty cycle signals, a second mode for generating during a 24 hour time period said compound electric signal and two of said additional 50% duty cycle signals, and a third mode for generating during a 24 hour time period said compound electric signal and one of said additional 50% duty cycle signals.
6. ~A device as in claim 5, wherein said signal generator comprises a switch that may be manually or automatically switched to switch said signal generator into different modes.
7. ~A device as in claim 1, further comprising means for holding said signal generator in proximity of a patient for communication with said capacitive and/or inductive coupling device.
8. ~A device as in claim 7, wherein said holding means comprises a Velcro .TM. strap that holds said signal generator to one of a patient's leg and a knee wrap.
9. ~A device as in claim 7, wherein said holding means comprises a pocket in one of a knee wrap and leg wrap.
10. ~A device as in claim 7, wherein said holding means comprises one of a pocket and a holster worn at the patient's waist.
11. ~A device as in claim 1, wherein said communicating means comprises one of an electric lead and a wireless connection.
12. ~A device as in claim 1, wherein said signal generator comprises a microcontroller responsive to time of day data to selectively generate said compound electric signals at predetermined treatment times.
13. ~A device as in claim 1, wherein said signal generator generates compound electric signals that down-regulate the gene expression of metalloproteases and other proteases in the treatment of cancer and in the prevention of metastases in cancer.
14. ~A device as in claim 1, wherein said signal generator is selectable to generate said compound electric signal at different voltages in accordance with a circumference of a patient's knee.
15. ~A non-invasive electromagnetic therapeutic method for treating defective or diseased tissue in a human knee joint, comprising the steps of:
generating compound electric signals comprising a 60kHz sine wave having a peak to peak voltage of approximately 4.6 V to 7.6 V and a 100% duty cycle signal that is generated for approximately 30 minutes and a 50% duty cycle signal that is generated for approximately 1 hour after said 100% duty cycle signal; and communicating said compound electric signals to one of a capacitive coupling and an inductive coupling device in the proximity of a patient's knee for the generation of a specific and selective electromagnetic field that treats said diseased tissue.
16. ~A method as in claim 15, wherein said generating step comprises the step of generating during a 24 hour time period at least one additional 50%
duty cycle signal having a duration of approximately 1 hour.
17. ~A method as in claim 16, wherein said generating step comprises the step of selecting one of at least three duty cycle modes, a first mode for generating during a 24 hour time period said compound electric signal and three of said additional 50% duty cycle signals, a second mode for generating during a 24 hour time period said compound electric signal and two of said additional 50% duty cycle signals, and a third mode for generating during a 24 hour time period said compound electric signal and one of said additional 50% duty cycle signals.
18. ~A method as in claim 15, comprising wherein said generating step comprises the step of selecting a voltage for said compound electric signal in accordance with a circumference of a patient's knee.
CA2530492A 2003-06-25 2004-06-14 Portable electrotherapy device for knee joint maladies Active CA2530492C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/603,226 2003-06-25
US10/603,226 US7130692B2 (en) 2000-02-23 2003-06-25 Portable electrotherapy device for treating osteoarthritis and other diseases, defects and injuries of the knee joint
PCT/US2004/019142 WO2005002667A1 (en) 2003-06-25 2004-06-14 Portable electrotherapy device for knee joint maladies

Publications (2)

Publication Number Publication Date
CA2530492A1 true CA2530492A1 (en) 2005-01-13
CA2530492C CA2530492C (en) 2010-09-21

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CA2530492A Active CA2530492C (en) 2003-06-25 2004-06-14 Portable electrotherapy device for knee joint maladies

Country Status (17)

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US (1) US7130692B2 (en)
EP (1) EP1644074B1 (en)
JP (1) JP2007523671A (en)
KR (1) KR20060025568A (en)
CN (1) CN1826152A (en)
AT (1) ATE437671T1 (en)
AU (1) AU2004253470A1 (en)
BR (1) BRPI0411818A (en)
CA (1) CA2530492C (en)
CR (1) CR8165A (en)
DE (1) DE602004022302D1 (en)
ES (1) ES2330225T3 (en)
IL (1) IL172775A0 (en)
NO (1) NO20060414L (en)
NZ (1) NZ544884A (en)
WO (1) WO2005002667A1 (en)
ZA (1) ZA200600694B (en)

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Also Published As

Publication number Publication date
WO2005002667A1 (en) 2005-01-13
US20050010264A1 (en) 2005-01-13
DE602004022302D1 (en) 2009-09-10
CN1826152A (en) 2006-08-30
EP1644074B1 (en) 2009-07-29
ATE437671T1 (en) 2009-08-15
CA2530492C (en) 2010-09-21
IL172775A0 (en) 2006-04-10
ES2330225T3 (en) 2009-12-07
BRPI0411818A (en) 2006-08-08
EP1644074A1 (en) 2006-04-12
JP2007523671A (en) 2007-08-23
AU2004253470A1 (en) 2005-01-13
KR20060025568A (en) 2006-03-21
NO20060414L (en) 2006-03-22
CR8165A (en) 2006-09-12
US7130692B2 (en) 2006-10-31
NZ544884A (en) 2008-03-28
ZA200600694B (en) 2007-05-30
EP1644074A4 (en) 2008-06-11

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