CA2531833A1 - Poly-4-hydroxybutyrate matrices for sustained drug delivery - Google Patents

Poly-4-hydroxybutyrate matrices for sustained drug delivery Download PDF

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Publication number
CA2531833A1
CA2531833A1 CA002531833A CA2531833A CA2531833A1 CA 2531833 A1 CA2531833 A1 CA 2531833A1 CA 002531833 A CA002531833 A CA 002531833A CA 2531833 A CA2531833 A CA 2531833A CA 2531833 A1 CA2531833 A1 CA 2531833A1
Authority
CA
Canada
Prior art keywords
hydroxybutyrate
poly
drug delivery
systems
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002531833A
Other languages
French (fr)
Other versions
CA2531833C (en
Inventor
Vasif N. Hasirci
Dilek Keskin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tepha Inc
Original Assignee
Tepha, Inc.
Vasif N. Hasirci
Dilek Keskin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tepha, Inc., Vasif N. Hasirci, Dilek Keskin filed Critical Tepha, Inc.
Publication of CA2531833A1 publication Critical patent/CA2531833A1/en
Application granted granted Critical
Publication of CA2531833C publication Critical patent/CA2531833C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

Biodegradable controlled release systems providing prolonged controlled release of drugs, and methods for the manufacture thereof are disclosed. The systems are formed from a biocompatible, biodegradable polymer, in particular poly-4-hydroxybutyrate (PHA4400) or copolymers thereof. Copolymers of 4-hydroxybutyrate include but are not limited to poly-3-hydroxybutyrate-co-4-hydroxybutyrate (PHA3444), and poly-4-hydoxybutyrate-co-glycolate (PHA4422).
Drugs are generally incorporated into the polymer using a method that yields a uniform dispersion. The type of drug and the quantity are selected based on the known pharmaceutical properties of these compounds. The systems may be administered for example by implantation, injection, topical administration, or oral ingestion. They may also be used in combination with a medical device, for example, a stent. A major advantage of the drug delivery system is that it does not need to be removed after use since it is slowly degraded and cleared by the patient's body. The device has desirable physical properties, including strength, modulus and elongation.
CA002531833A 2003-07-08 2004-07-08 Poly-4-hydroxybutyrate matrices for sustained drug delivery Active CA2531833C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US48537303P 2003-07-08 2003-07-08
US60/485,373 2003-07-08
US49143003P 2003-07-30 2003-07-30
US60/491,430 2003-07-30
PCT/US2004/022040 WO2005007195A1 (en) 2003-07-08 2004-07-08 Poly-4-hydroxybutyrate matrices for sustained drug delivery

Publications (2)

Publication Number Publication Date
CA2531833A1 true CA2531833A1 (en) 2005-01-27
CA2531833C CA2531833C (en) 2009-10-20

Family

ID=34083339

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002531833A Active CA2531833C (en) 2003-07-08 2004-07-08 Poly-4-hydroxybutyrate matrices for sustained drug delivery

Country Status (7)

Country Link
US (1) US20050025809A1 (en)
EP (1) EP1651273B1 (en)
JP (1) JP2007528853A (en)
AU (1) AU2004257701B2 (en)
CA (1) CA2531833C (en)
ES (1) ES2395077T3 (en)
WO (1) WO2005007195A1 (en)

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Also Published As

Publication number Publication date
EP1651273A1 (en) 2006-05-03
JP2007528853A (en) 2007-10-18
ES2395077T3 (en) 2013-02-08
WO2005007195A1 (en) 2005-01-27
AU2004257701A1 (en) 2005-01-27
US20050025809A1 (en) 2005-02-03
AU2004257701B2 (en) 2007-09-13
EP1651273B1 (en) 2012-08-29
CA2531833C (en) 2009-10-20

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