CA2542469A1 - Method and apparatus for controlled reoxygenation - Google Patents
Method and apparatus for controlled reoxygenation Download PDFInfo
- Publication number
- CA2542469A1 CA2542469A1 CA002542469A CA2542469A CA2542469A1 CA 2542469 A1 CA2542469 A1 CA 2542469A1 CA 002542469 A CA002542469 A CA 002542469A CA 2542469 A CA2542469 A CA 2542469A CA 2542469 A1 CA2542469 A1 CA 2542469A1
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- blood
- operable
- perfusion device
- oxygen
- sensor
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/32—Oxygenators without membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3613—Reperfusion, e.g. of the coronary vessels, e.g. retroperfusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
- A61M2202/047—Liquids non-physiological cardioplegic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/205—Blood composition characteristics partial oxygen pressure (P-O2)
Abstract
A method and apparatus for performing coronary perfusion and cardiac reoxygenation that enables accurate control of oxygen levels in blood used for the coronary circulation. Deoxygenated blood and oxygenated blood are collected and oxygen levels are measured by sensors. The deoxygenated and oxygenated blood is then mixed and the mixed blood is measured by another sensor. The sensors provide data used to provide real-time oxygen level measurement and adjustment for blood supplied for coronary circulation.
Claims (55)
1. A perfusion device for controlled reoxygenation, the device comprising:
a perfusion control input operable to receive a desired blood oxygen level;
a venous blood sensor operable to measure oxygen levels in venous blood;
an oxygenated blood sensor operable to measure oxygen levels in oxygenated blood;
a mixed blood supply operable to receive venous blood and oxygenated blood;
a mixed blood sensor operable to measure oxygen levels in the mixed blood supply; and a venous blood pump operable to move venous blood to the mixed blood supply;
an oxygenated blood pump operable to move oxygenated blood to the mixed blood supply;
a microprocessor operable to receive data from said perfusion control input, said venous blood sensor, said oxygenated blood sensor, and said mixed blood sensor;
wherein the microprocessor controls the venous blood and oxygenated blood pumps to provide a desired blood oxygen level in the mixed blood supply.
a perfusion control input operable to receive a desired blood oxygen level;
a venous blood sensor operable to measure oxygen levels in venous blood;
an oxygenated blood sensor operable to measure oxygen levels in oxygenated blood;
a mixed blood supply operable to receive venous blood and oxygenated blood;
a mixed blood sensor operable to measure oxygen levels in the mixed blood supply; and a venous blood pump operable to move venous blood to the mixed blood supply;
an oxygenated blood pump operable to move oxygenated blood to the mixed blood supply;
a microprocessor operable to receive data from said perfusion control input, said venous blood sensor, said oxygenated blood sensor, and said mixed blood sensor;
wherein the microprocessor controls the venous blood and oxygenated blood pumps to provide a desired blood oxygen level in the mixed blood supply.
2. The perfusion device of claim 1 wherein the mixed blood supply is a reservoir, blood line, or bladder.
3. The perfusion device controller of claim 1 further comprising a mixed blood supply pump connected with said mixed blood supply.
4. The perfusion device of claim 1 wherein the oxygen levels comprise partial pressure of oxygen.
5. The perfusion device of claim 1 wherein the oxygen levels comprise oxygen saturation.
6. The perfusion device of claim 1 wherein the oxygen levels comprise oxygen saturation and partial pressure of oxygen.
7. The perfusion device of claim 1 further comprising a display connected with the microprocessor.
8. The perfusion device of claim 7 wherein said perfusion control input and said display are a touch screen.
9. The perfusion device of claim 1 wherein the perfusion control input is a dial.
10. The perfusion device of claim 1 further comprising a cardioplegia solution delivery device connected with said mixed blood supply.
11. A coronary perfusion device comprising:
a venous drainage pathway;
a systemic perfusion pathway;
a cardioplegia delivery pathway;
an oxygenator having an input connected with the venous drainage pathway, one or more outputs connected with the systemic delivery pathway and an oxygenation controller;
wherein said oxygenation controller reads data from at least one blood oxygen level sensor and mixes blood from the venous drainage pathway and systemic delivery pathway to create a mixed blood supply.
a venous drainage pathway;
a systemic perfusion pathway;
a cardioplegia delivery pathway;
an oxygenator having an input connected with the venous drainage pathway, one or more outputs connected with the systemic delivery pathway and an oxygenation controller;
wherein said oxygenation controller reads data from at least one blood oxygen level sensor and mixes blood from the venous drainage pathway and systemic delivery pathway to create a mixed blood supply.
12. The coronary perfusion device of claim 11 wherein said at least one blood oxygen level sensor is operable to measure partial pressure of oxygen in blood.
13. A method for controlled reoxygenation, comprising:
providing a venous blood supply;
providing an oxygenated blood supply;
providing at least one sensor for measuring blood oxygen levels;
providing a desired output blood oxygen level;
mixing blood from the venous blood supply with blood from the oxgyenated blood supply;
collecting blood oxygen level data;
comparing a mixed blood oxygen level with the desired blood oxygen level; and adjusting the mixture of blood in response to the comparison.
providing a venous blood supply;
providing an oxygenated blood supply;
providing at least one sensor for measuring blood oxygen levels;
providing a desired output blood oxygen level;
mixing blood from the venous blood supply with blood from the oxgyenated blood supply;
collecting blood oxygen level data;
comparing a mixed blood oxygen level with the desired blood oxygen level; and adjusting the mixture of blood in response to the comparison.
14. The method of claim 13 further comprising the act of providing the mixed blood for coronary circulation.
15. The method of claim 13 wherein the act of adjusting the mixture of blood comprises adjusting flow rates from the venous blood supply and oxygenated blood supply.
16. The method of claim 13 wherein the blood oxygen level data corresponds to measurements of partial pressure of oxygen in the blood.
17. The method of claim 13 wherein said at least one sensor for measuring blood oxygen levels comprises a venous blood sensor, oxygenated blood sensor, and mixed blood sensor.
18. A coronary perfusion device, comprising:
a microprocessor;
one or more memories connected with the microprocessor and operable to store (a) data corresponding to a real-time blood oxygen level for deoxygenated blood, (b) data corresponding to a real-time blood oxygen level for oxygenated blood, (c) data corresponding to a real-time blood oxygen level corresponding to a mixture of deoxygenated and oxygenated blood, and (d) data corresponding to a desired blood oxygen level for the mixture of deoxygenated and oxygenated blood;
wherein the microprocessor is operable to adjust the amount of deoxygenated and oxygenated blood provided to the mixture of deoxygenated and oxygenated blood as a function of at least some of the stored data.
a microprocessor;
one or more memories connected with the microprocessor and operable to store (a) data corresponding to a real-time blood oxygen level for deoxygenated blood, (b) data corresponding to a real-time blood oxygen level for oxygenated blood, (c) data corresponding to a real-time blood oxygen level corresponding to a mixture of deoxygenated and oxygenated blood, and (d) data corresponding to a desired blood oxygen level for the mixture of deoxygenated and oxygenated blood;
wherein the microprocessor is operable to adjust the amount of deoxygenated and oxygenated blood provided to the mixture of deoxygenated and oxygenated blood as a function of at least some of the stored data.
19. The coronary perfusion device of claim 18 wherein the stored data is received from at least one sensor.
20. The coronary perfusion device of claim 18 wherein said one or more memories connected with the microprocessor are operable to store (e) data corresponding to a real-time flow rate of the deoxygenated blood and (f) data corresponding to a real-time flow rate of the oxygenated blood.
21. The coronary perfusion device of claim 18, wherein the blood oxygen levels are measurements of partial pressure of oxygen in blood.
22. A method for controlled cardiac reoxygenation, comprising:
providing a deoxygenated blood supply;
providing an oxygenated blood supply;
receiving real-time blood oxygen level and flow rate data for the deoxygenated blood;
receiving real-time blood oxygen level and flow rate data for the oxygenated blood;
mixing blood from the dexogyenated blood supply with blood from the oxygenated blood supply;
receiving real-time blood oxygen level data for the mixed blood; and adjusting the flow rates of at least one of oxygenated blood, deoxygenated blood or combinations thereof as a function of a desired blood oxygen level for the mixed blood.
providing a deoxygenated blood supply;
providing an oxygenated blood supply;
receiving real-time blood oxygen level and flow rate data for the deoxygenated blood;
receiving real-time blood oxygen level and flow rate data for the oxygenated blood;
mixing blood from the dexogyenated blood supply with blood from the oxygenated blood supply;
receiving real-time blood oxygen level data for the mixed blood; and adjusting the flow rates of at least one of oxygenated blood, deoxygenated blood or combinations thereof as a function of a desired blood oxygen level for the mixed blood.
23. The method of claim 22 further comprising the act of displaying the real-time blood oxygen level for the mixed blood.
24. The method of claim 22 wherein the blood oxygen levels are measurements of partial pressure of oxygen in the blood.
25. A coronary perfusion device, comprising:
a control input operable to receive a desired blood oxygen level;
a venous blood supply input operable to receive deoxygenated blood;
an oxygenated blood supply input operable to receive oxygenated blood;
a mixed blood line connected with said venous blood supply input and said oxygenated blood supply input;
a mixed blood sensor operable to measure blood oxygen levels in the mixed blood line; and a microprocessor operable to receive data from said control input and said mixed blood sensor;
wherein the microprocessor controls a mixture of the venous blood with the oxygenated blood as a function of the desired blood oxygen level.
a control input operable to receive a desired blood oxygen level;
a venous blood supply input operable to receive deoxygenated blood;
an oxygenated blood supply input operable to receive oxygenated blood;
a mixed blood line connected with said venous blood supply input and said oxygenated blood supply input;
a mixed blood sensor operable to measure blood oxygen levels in the mixed blood line; and a microprocessor operable to receive data from said control input and said mixed blood sensor;
wherein the microprocessor controls a mixture of the venous blood with the oxygenated blood as a function of the desired blood oxygen level.
26. The coronary perfusion device of claim 25 further comprising:
a venous blood sensor operable to measure oxygen levels of the deoxygenated blood; and an oxygenated blood sensor operable to measure oxygen levels of the oxygenated blood;
wherein the microprocessor is further operable to receive data from said venous blood sensor and said oxygenated blood sensor.
a venous blood sensor operable to measure oxygen levels of the deoxygenated blood; and an oxygenated blood sensor operable to measure oxygen levels of the oxygenated blood;
wherein the microprocessor is further operable to receive data from said venous blood sensor and said oxygenated blood sensor.
27. The coronary perfusion device of claim 25 further comprising:
a venous blood pump connected with the venus blood supply input and operable to adjust flow of venous blood; and an oxygenated blood pump connected with the oxygenated blood supply input and operable to adjust flow of oxygenated blood;
a venous blood pump connected with the venus blood supply input and operable to adjust flow of venous blood; and an oxygenated blood pump connected with the oxygenated blood supply input and operable to adjust flow of oxygenated blood;
28. The coronary perfusion device of claim 25, wherein the oxygen levels are measurements of partial pressure of oxygen in the blood.
29. The coronary perfusion device of claim 25 further comprising a mixed blood supply connected with said mixed blood line, said mixed blood supply operable to hold mixed blood.
30. The coronary perfusion device of claim 25 further comprising a mixed blood supply having a first input connected with said oxygenated blood input, a second input connected with said venous blood input, and output connected with said mixed blood line.
31. The reoxygenation controller of claim 25 further comprising a mixed blood pump connected with said mixed blood line.
32. The coronary perfusion device of claim 25 further comprising:
a display connected with said microprocessor and operable to display blood oxygen level data.
a display connected with said microprocessor and operable to display blood oxygen level data.
33. The coronary perfusion device of claim 25 wherein the control input comprises a touch screen.
34. The coronary perfusion device of claim 33 wherein the touch screen is operable to receive a tactile input and display blood oxygen level data.
35. The coronary perfusion device of claim 25 wherein the control input is a dial.
36. The coronary perfusion device of claim 25 wherein the mixed blood sensor measures partial pressure of oxygen in blood.
37. The coronary perfusion device of claim 26 wherein the venous blood sensor and oxygenated blood sensor measure partial pressure of oxygen in blood.
38. A coronary perfusion device, comprising:
a first reservoir operable to hold deoxygenated blood;
a first sensor operable to measure oxygen levels of blood in the first reservoir;
a second reservoir operable to hold oxygenated blood;
a second sensor operable to measure oxygen levels of blood in the second reservoir;
a third reservoir operable to receive blood from said first and second reservoirs; and a third sensor operable to measure oxygen levels of blood in the third reservoir;
wherein the third reservoir provides blood for coronary circulation.
a first reservoir operable to hold deoxygenated blood;
a first sensor operable to measure oxygen levels of blood in the first reservoir;
a second reservoir operable to hold oxygenated blood;
a second sensor operable to measure oxygen levels of blood in the second reservoir;
a third reservoir operable to receive blood from said first and second reservoirs; and a third sensor operable to measure oxygen levels of blood in the third reservoir;
wherein the third reservoir provides blood for coronary circulation.
39. The coronary perfusion device of claim 38 wherein the first, second, and third reservoirs and first, second, and third sensors are contained in a disposable bladder.
40. The coronary perfusion device of claim 38 wherein the third reservoir and third sensor are contained in a disposable bladder.
41. The coronary perfusion device of claim 38 wherein the first, second, and third sensors measure partial pressure of oxygen.
42. The coronary perfusion device of claim 38 wherein the first, second, and third sensors measure partial pressure of oxygen and oxygen saturation.
43. A coronary perfusion device, comprising:
a first blood line operable to hold deoxygenated blood;
a first sensor operable to measure oxygen levels of blood in the first blood line;
a second blood line operable to hold oxygenated blood;
a second sensor operable to measure oxygen levels of blood in the second blood line;
a third blood line operable to receive blood from said first and second blood lines; and a third sensor operable to measure oxygen levels of blood in the third blood line;
wherein the third blood line provides blood for coronary circulation.
a first blood line operable to hold deoxygenated blood;
a first sensor operable to measure oxygen levels of blood in the first blood line;
a second blood line operable to hold oxygenated blood;
a second sensor operable to measure oxygen levels of blood in the second blood line;
a third blood line operable to receive blood from said first and second blood lines; and a third sensor operable to measure oxygen levels of blood in the third blood line;
wherein the third blood line provides blood for coronary circulation.
44. The coronary perfusion device of claim 43 wherein the first, second, and third blood lines and first, second, and third sensors are contained in a disposable bladder.
45. The coronary perfusion device of claim 43 wherein the third blood line and third sensor are contained in a disposable bladder.
46. The coronary perfusion device of claim 43 wherein the first, second, and third sensors measure partial pressure of oxygen.
47. The coronary perfusion device of claim 43 wherein the first, second, and third sensors measure partial pressure of oxygen and oxygen saturation.
48. The coronary perfusion device of claim 43 further comprising:
a first reservoir connected with the first blood line;
a second reservoir connected with the second blood line; and a third reservoir connected with the third blood line.
a first reservoir connected with the first blood line;
a second reservoir connected with the second blood line; and a third reservoir connected with the third blood line.
49. A coronary perfusion device, comprising:
a first blood supply operable to hold deoxygenated blood;
a second blood supply operable to hold oxygenated blood;
a third blood supply operable to receive blood from said first and second blood supplies; and at least one sensor operable to measure oxygen levels of blood in the third blood supply;
wherein the third blood line provides blood for coronary circulation and the first, second, and third blood supplies and at least one sensor are contained in a disposable bladder
a first blood supply operable to hold deoxygenated blood;
a second blood supply operable to hold oxygenated blood;
a third blood supply operable to receive blood from said first and second blood supplies; and at least one sensor operable to measure oxygen levels of blood in the third blood supply;
wherein the third blood line provides blood for coronary circulation and the first, second, and third blood supplies and at least one sensor are contained in a disposable bladder
50. The coronary perfusion device of claim 49 wherein said at least one sensor measures partial pressure of oxygen.
51. The coronary perfusion device of claim 49 wherein said at least one sensor measures partial pressure of oxygen and oxygen saturation.
52. The coronary perfusion device of claim 49 further comprising at least one sensor operable to measure oxygen levels of blood in the first blood supply.
53. The coronary perfusion device of claim 49 further comprising at least one sensor operable to measure oxygen levels of blood in the second blood supply.
54. The coronary perfusion device of claim 49 wherein said first, second, and third blood supplies are reservoirs.
55. The coronary perfusion device of claim 49 where said first, second, and third blood supplies are blood lines.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51183703P | 2003-10-16 | 2003-10-16 | |
| US60/511,837 | 2003-10-16 | ||
| US10/869,739 US7455812B2 (en) | 2003-10-16 | 2004-06-16 | Method and apparatus for controlled reoxygenation |
| US10/869,739 | 2004-06-16 | ||
| PCT/US2004/031785 WO2005039687A1 (en) | 2003-10-16 | 2004-09-29 | Method and apparatus for controlled reoxygenation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2542469A1 true CA2542469A1 (en) | 2005-05-06 |
| CA2542469C CA2542469C (en) | 2009-12-01 |
Family
ID=34526642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002542469A Expired - Fee Related CA2542469C (en) | 2003-10-16 | 2004-09-29 | Method and apparatus for controlled reoxygenation |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US7455812B2 (en) |
| EP (1) | EP1684845B1 (en) |
| AT (1) | ATE546177T1 (en) |
| CA (1) | CA2542469C (en) |
| WO (1) | WO2005039687A1 (en) |
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-
2004
- 2004-06-16 US US10/869,739 patent/US7455812B2/en not_active Expired - Fee Related
- 2004-09-29 AT AT04789148T patent/ATE546177T1/en active
- 2004-09-29 EP EP04789148A patent/EP1684845B1/en not_active Not-in-force
- 2004-09-29 WO PCT/US2004/031785 patent/WO2005039687A1/en active Search and Examination
- 2004-09-29 CA CA002542469A patent/CA2542469C/en not_active Expired - Fee Related
-
2008
- 2008-02-12 US US12/069,608 patent/US7708942B2/en active Active
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2010
- 2010-03-29 US US12/748,529 patent/US8178041B2/en active Active
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2012
- 2012-05-14 US US13/470,671 patent/US8709343B2/en active Active
-
2014
- 2014-04-29 US US14/264,211 patent/US9211371B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1684845B1 (en) | 2012-02-22 |
| EP1684845A4 (en) | 2007-06-06 |
| US20050084416A1 (en) | 2005-04-21 |
| WO2005039687A1 (en) | 2005-05-06 |
| US8178041B2 (en) | 2012-05-15 |
| US20100185136A1 (en) | 2010-07-22 |
| CA2542469C (en) | 2009-12-01 |
| US8709343B2 (en) | 2014-04-29 |
| US7708942B2 (en) | 2010-05-04 |
| EP1684845A1 (en) | 2006-08-02 |
| US7455812B2 (en) | 2008-11-25 |
| ATE546177T1 (en) | 2012-03-15 |
| US9211371B2 (en) | 2015-12-15 |
| US20080161740A1 (en) | 2008-07-03 |
| US20130131638A1 (en) | 2013-05-23 |
| US20150057589A1 (en) | 2015-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20190930 |