CA2544296C - Implantable valvular prosthesis - Google Patents

Implantable valvular prosthesis Download PDF

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Publication number
CA2544296C
CA2544296C CA2544296A CA2544296A CA2544296C CA 2544296 C CA2544296 C CA 2544296C CA 2544296 A CA2544296 A CA 2544296A CA 2544296 A CA2544296 A CA 2544296A CA 2544296 C CA2544296 C CA 2544296C
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CA
Canada
Prior art keywords
prosthetic valve
valve
membrane assembly
structural frame
cantilever
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2544296A
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French (fr)
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CA2544296A1 (en
Inventor
David Christopher Majercak
Hikmat Hojeibane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cardinal Health Switzerland 515 GmbH
Original Assignee
Cordis Corp
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Publication date
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Publication of CA2544296A1 publication Critical patent/CA2544296A1/en
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Publication of CA2544296C publication Critical patent/CA2544296C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2475Venous valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418Scaffolds therefor, e.g. support stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008Fixation appliances for connecting prostheses to the body
    • A61F2220/0016Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028Shapes in the form of latin or greek characters
    • A61F2230/0054V-shaped

Abstract

The present invention relates to a stent-based valve (100). The valve includes a radially expandable structural frame (101) including an anchor structure (104), a connecting member (105), and a cantilever valve strut (107). The connecting member is attached to the anchor structure. The cantilever valve strut is cooperatively associated with the connecting member. The prosthetic valve further includes a biocompatible membrane assembly (102) having a substantially tubular configuration disposed longitudinally about at least a portion of the connecting member. The membrane assembly has a first diameter and a second end having a second diameter, wherein the first diameter is greater than the second diameter. An end of the membrane assembly is attached along an end of the cantilever valve strut.

Description

IMPLANTABLE VALVULAR PROSTHESIS

FIELD OF THE INVENTION

The present invention relates to a medical device, and more particularly to a frame based unidirectional flow prosthetic valve, and the method for fabricating such valve.
BACKGROUND OF RELATED ART

The human body has numerous biological valves that control fluid flow through body lumens and vessels. For example the circulatory system has various heart valves that allow the heart to act as a pump by controlling the flow of blood through the heart chambers, veins, and aorta. In addition, the venous system has numerous venous valves that help control the flow of blood back to the heart, particularly from the lower extremities.

These valves can become incompetent or damaged by disease, for example, phlebitis, injury, or the result of an inherited malformation. Heart valves are subject to disorders, such as mitral stenosis, mitral regurgitation, aortic stenosis, aortic regurgitation, mitral valve prolapse and tricuspid stenosis. These disorder are potentially life threatening. Similarly, incompetent or damaged venous valves usually leak, allowing the blood to improperly flow back down through veins away from the heart (regurgitation ref lux or retrograde blood flow). Blood can then stagnate in sections of certain veins, and in particular, the veins in the lower extremities. This stagnation of blood raises blood pressure and dilates the veins and venous valves. The dilation of one vein may in turn disrupt the proper function of other venous valves in a cascading manner, leading to chronic venous insufficiency.

Numerous therapies have been advanced to treat symptoms and to correct incompetent valves. Less invasive procedures include compression, elevation and wound care. However, these treatments tend to be somewhat expensive and are not curative. Other procedures involve surgical intervention to repair, reconstruct or replace the incompetent or damaged valves, particularly heart valves.

Surgical procedures for incompetent or damaged venous valves include valvuloplasty, transplantation, and transposition of veins. However, these surgical procedures provide somewhat limited results. The leaflets of some venous valves are generally thin, and once the valve becomes incompetent or destroyed, any repair provides only marginal relief.
2 As an alternative to surgical intervention, drug therapy to correct valvular incompetence has been utilized.
Currently, however, there are no effective drug therapies available.

Other means and methods for treating and/or correcting damaged or 'incompetent valves include utilizing xenograft valve transplantation (monocusp bovine pericardium), prosthetic/bioprosthetic heart valves and vascular grafts, and artificial venous valves. These means have all had somewhat limited results.

What is needed is an artificial endovascular (endoluminal) valve for the replacement of incompetent biological human valves, particularly heart and venous valves. These valves may also find use in artificial hearts and artificial heart assist pumps used in conjunction with heart transplants.

SUMMARY OF THE INVENTION

The present 'invention relates to a medical device, and in particular, to a stent-based valve. A prosthetic valve comprises a radially expandable structural frame defining a longitudinal axis. The structural frame includes an anchor structure having a first and a second open end, a connecting
3 member having a first and a second end, and a cantilever valve strut having a first and a second end. The first end of the connecting member is attached to the second end of the anchor structure. The first end of the cantilever valve strut is cooperatively associated with the second end of the connecting member. The prosthetic valve further includes a biocompatible membrane assembly having a substantially tubular configuration disposed longitudinally about the structural frame. The membrane assembly has a first end having a first diameter and a second end having a second diameter, wherein the first diameter is greater than the second diameter. The first end of the membrane assembly is attached along the second end of the cantilever valve strut.

More particularly, there is provided a prosthetic valve comprising:
a radially expandable structural frame defining a longitudinal axis, including an anchor structure having first and second open ends, a connecting member having first and second ends, the first end of the connecting member being attached to the second end of the anchor structure, and a cantilever valve strut having first and a second ends, the first end of the cantilever valve strut being cooperatively associated with the second end of the connecting member; and a biocompatible membrane assembly having a substantially tubular configuration disposed longitudinally about the structural frame, the membrane assembly including a first end having a first diameter and a second end having a second diameter, wherein the first diameter is greater than the second diameter, the first end of the membrane assembly being attached along the second end of the cantilever valve strut, wherein the structural frame comprises a proximal collar attached to the second end of the connecting member and first end of the cantilever valve strut.
4 In another embodiment of the invention, the prosthetic valve comprises a radially expandable anchor structure formed from a lattice of interconnected elements. The anchor has a substantially cylindrical configuration with a first and a second open end and a longitudinal axis defining a longitudinal direction extending there between. A connecting member and a cantilever valve strut, each having first and second ends, are also provided. The first end of the connecting member is attached to the second end of the anchor. The first end of the cantilever valve strut is 4a cooperatively associated with the second end of the connecting member. The prosthetic valve further includes a biocompatible membrane assembly having a substantially tubular configuration disposed longitudinally about at least a portion of the connecting member. The membrane assembly has a first end having a first diameter and a second end having a second diameter, wherein the first diameter is greater than the second diameter. The first end of the membrane assembly is attached along the second end of the cantilever valve strut.

In still another embodiment of the present invention, the prosthetic valve comprises a radially expandable anchor structure formed from a lattice of interconnected elements.
The anchor structure has a substantially cylindrical configuration with a first and a second open end and a longitudinal axis defining a longitudinal direction extending there between. A collar is provided and located proximal to the radially expandable anchor. At least one connecting member having a first and a second end is provided such that the first end of the connecting member is attached to the second end of the anchor and the second end of the connecting member is attached to the proximal collar.
A cantilever valve strut having a first and a second end is
5 also provided. The first end of the cantilever valve strut is attached to the proximal collar and extends in a distal direction substantially parallel to the longitudinal axis.
The prosthetic valve further includes a biocompatible membrane assembly having a substantially tubular configuration disposed longitudinally about at least a portion of the connecting member. The membrane assembly has a first end having a first diameter and a second end having a second diameter, wherein the first diameter is greater than the second diameter. The first end of the membrane assembly is attached along the second end of the cantilever valve strut.

BRIEF DESCRIPTION OF THE DRAWINGS

Figure 1A shows a perspective view of a prosthetic venous valve in the deployed state according to one embodiment of the present invention.

Figure 2A shows a perspective view of the prosthetic venous valve structural frame in the deployed state according to one embodiment of the present invention.

Figure 2B shows a perspective view of the prosthetic venous valve structural frame having helical connecting
6 members according to one embodiment of the present invention.

Figure 2C shows a perspective view of the prosthetic venous valve structural frame having a sinusoidal cantilever valve strut assembly according to one embodiment of the present invention.

Figure 2D shows a perspective. view of the prosthetic venous valve structural frame having a helical valve strut assembly according to one embodiment of the present invention.

Figure 2E shows a perspective view of the prosthetic venous valve structural frame having a proximal centering mechanism in the deployed state according to one embodiment of the present invention.

Figure 2F shows a perspective view of the prosthetic venous valve structural frame having distal and proximal anchor mechanisms according to one embodiment of the present invention.

Figure 3A shows a perspective view of the distal stent anchor having a plurality of hoop structures according to one embodiment of the present invention.
7 Figure 3B shows a close-up perspective view of a loop member from the anchor having inner and outer radii according to one embodiment of the present invention.

Figure 3C illustrates a single hoop anchor having three connecting members connected to the proximal end of the distal anchor at the outer radii of the inflection point of the loop members.

Figure 3D illustrates a single hoop anchor having three connecting members connected to the proximal end of the distal anchor at the inner radii of the inflection point of the loop members.

Figure 3E illustrates a single hoop anchor having three connecting members connected to the proximal end of the distal anchor along the strut members connecting the loop members.

Figure 4A is a perspective view illustrating one embodiment of the deployed prosthetic venous valve assembly in the open position.

Figure 4B is a section view illustrating one embodiment of the deployed prosthetic venous valve assembly in the open position.
8
9 PCT/US2004/034478 Figure 5A is a perspective view illustrating one embodiment of the deployed prosthetic venous valve assembly in the closed position.

Figure 5B is a section view illustrating one embodiment of the deployed prosthetic venous valve assembly in the closed position.

Figure 6A is a perspective view illustrating a membrane limiting means according to one embodiment of the present invention.

Figure 6B is a perspective view illustrating a membrane limiting means according to one embodiment of the present invention.

Figure 6C is a perspective view illustrating a membrane limiting means according to one embodiment of the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

The stent-based valves of the present invention provide a method for overcoming the difficulties associated with the treatment of valve insufficiency. Although stent based venous valves are disclosed to illustrate one embodiment of the present invention, one of ordinary skill in the art would understand that the disclosed invention can be equally applied to other locations and lumens in the body, such as, for example, coronary, vascular, non-vascular and peripheral vessels, ducts, and the like, including but not limited to cardiac valves, venous valves, valves in the esophagus and at the stomach, valves in the ureter and/or the vesica, valves in the biliary passages, valves in the lymphatic system and valves in the intestines.

In accordance with one aspect of the present invention, the prosthetic valve is designed to be percutaneously delivered through a body lumen to a target site by a delivery catheter. The target site may be, for example, a location in the venous system adjacent to an insufficient venous valve. Once deployed the prosthetic venous valve functions to assist or replace the incompetent or damaged natural valve by allowing normal blood flow (antegrade blood flow) and preventing or reducing backflow (retrograde blood flow).

A perspective view of a prosthetic venous valve in the deployed state according to one embodiment of the present invention is shown in Figure 1. The prosthetic venous valve 100 comprises a structural frame 101 and a biocompatible membrane assembly 102. The membrane assembly 102 is a thin-walled biocompatible material formed into a tube with a closed end. Exemplary configurations of a closed end tube would include a tubular cup or cone shape, however one of skill in the art would understand that other configurations could also be used.

Alternatively, the cup or cone end of membrane assembly 102 may also be partially open, having a cross-sectional area that is substantially smaller than the open end of the membrane assembly. This reduced cross-sectional area must be sized to effectively minimize or reduce fluid flow past the prosthetic valve 100, substantially occluding the vessel, when the valve 100 is in the closed (expanded) position. The partially open-end configuration will allow fluid to pass through the tube (membrane assembly 102) during antegrade blood flow, preventing or reducing fluid stagnation within the tube. In applications where the prosthetic valve 100 is placed in the bloodstream, this reduced stagnation or pooling may decrease the risk of clotting.

For clarity, a perspective view of the prosthetic venous valve 100 structural frame 101 according to one embodiment of the present invention is shown in Figure 2A.
The structural frame 101 consists of an anchor structure 104 connected by at least one connecting member 105 to a proximal collar 108. In a preferred embodiment, at least three connecting members 105 are utilized. By way of example, the embodiment illustrated in Figure 2A shows four connecting members 105.

One or more cantilever valve struts 107 extend from the proximal collar 108 in a proximal direction (upstream) before looping back in a distal (downstream) direction substantially parallel to the structural frame 101 longitudinal axis 106. This configuration allows the cantilever valve strut 107 to be longer, increasing the flexibility of the struts 107 and helping to reduce the strains imposed in the structural frame 101 and/or membrane assembly 102. The cantilever valve struts 107 are attached to the biocompatible membrane assembly 102 (not shown in Figure 2A) and further support the assembly in the open and closed positions. The proximal collar 108 serves as a connection point between the one or move valve strut members 107 and the one or more connecting members 105.

Each of the cantilever valve struts 107 illustrated in Figure 2A have a loop end 112 incorporated into the proximal end and a single branch distal end 113. The loop end 112 of the valve strut 107 is attached directly to the proximal end of the proximal collar 108, and has a semi-circular configuration, substantially symmetric about its center.
This configuration allows the loop end 112 to effectively reverse the direction of the cantilever valve strut 107 from a proximal direction, where it attaches to the proximal end of proximal collar 108, to a distal direction.

In a preferred embodiment, at least three cantilever valve struts 107 are utilized. In the embodiment illustrated in Figures 2A four cantilever valve struts 107 are shown.

The number of cantilever valve struts 107 and connecting members 105 illustrated are not meant to limit the scope of the invention. One of skill in the art would understand that other quantities and combinations of valve struts 107 and connecting members 105 could be used and still accomplish the general intent of the invention.

In addition, the structural frame 101, particularly the connecting members 105 and/or cantilever valve struts 107 may include radiopaque markers or marker bands attached or integrated thereto. The radiopaque markers are opaque to radiation, especially to X rays and MRI, allowing the position of the structural frame 101 or its components to be viewed "in vivo". Figure 1 illustrates marker bands 103 along the cantilever valve strut 107 members.

It should be noted that the terms proximal and distal are typically used to connote a direction or position relative to a human body. For example, the proximal end of a bone may be used to reference the end of the bone that is closer to the center of the body. Conversely, the term distal can be used to refer to the end of the bone farthest from the body. In the vasculature, proximal and distal are sometimes used to refer to the flow of blood to the heart, or away from the heart, respectively. Since the prosthetic valves described in this invention can be used in many different body lumens, including both the arterial and venous system, the use of the terms proximal and distal in this application are used to describe relative position in relation to the direction of fluid flow. As used herein, the terms upstream and downstream are relative to the normal direction of fluid flow (antegrade flow). By way of example, for venous valves, downstream connotes a direction of blood flow toward the heart. Accordingly, the use of the term proximal in the present application describes an upstream member, section or relative position, regardless of its orientation relative to the body. The use of the term distal is used to describe a downstream member, section or relative position regardless of its orientation relative to the body. Similarly, the use of the terms proximal and distal to connote a direction describe upstream (retrograde) or downstream (antegrade) respectively.

In the embodiment illustrated in Figures 2A, the connecting members 105 are substantially linear members, connecting the stent based distal anchor 104 and the proximal collar 108. Alternatively, the connecting members 105 may be twisted in a helical fashion as they extend between the proximal collar 108 and the distal anchor 104.

This alternate embodiment is illustrated in Figure 2B.
Specifically, the connection points between the connecting members 105 and the distal anchor 104, and the connecting members 105 and the proximal collar 108, are rotationally phased 180 degrees from each other to provide the helical design.

Similarly, the distal end 113 of the cantilever valve struts 107 are illustrated as substantially straight members, but may take on other configurations. By way of example, Figure 2C shows a structural frame 101 having sinusoidal cantilever valve struts 107 along the distal end 113, while Figure 2D shows a structural frame 101 having helical cantilever valve struts 107 along the distal end 113. These various configurations may be used to change the properties of the structural frame, for example, by providing more flexibility in a particular plane or direction. Still other configurations are possible as would be understood by one of skill in the art.

The structural frame 101 could also include a secondary mechanism to center the proximal end of the frame in the body vessel or lumen. This mechanism may also provide additional anchoring to the vessel wall to further stabilize the prosthetic valve 100.

Figure 2E shows a centering mechanism 205 incorporated into the proximal end of the structural frame 101 according to one embodiment of the present invention. The centering mechanism 205 is comprised of one or more legs 210 that extend in a substantially radial direction from the longitudinal centerline 106 to the vessel wall (not shown).
In the illustrated embodiment, 4 legs 210 are shown for the purpose of example. The legs 210 terminate with a blunt end, such as the curved bend illustrated, to reduce the possibility of the leg end perforating the vessel wall. The opposite end of the leg 210 is attached to the structural frame at or near the proximal collar 108. In the embodiment illustrated in Figure 2E, the centering legs 210 are cut from the same tube as the remainder of the structural frame 101 such that the structural frame 101, including legs 210, is a one piece unit. Alternatively, the centering legs 210 may be separate wire units and crimped or suitably attached to the structural frame 101 at the proximal collar 108. The leg 210 may include barbs 215 on or along the end portion to further anchor the structural frame 101 to the vessel wall.
The structural frame 101 may also include a second anchor mechanism' 203, similar to anchor 104, as shown in Figure 2F. Aside from providing additional support and anchoring for the proximal end of the structural frame 101, the proximal anchor 203 may also act as a centering mechanism to center the proximal end of the structural frame 101 in the vessel or lumen (not shown). The proximal anchor 203 may be attached directly to the structural frame 101 at the proximal collar 108, or may be attached to the proximal collar by connecting members 206 as shown in Figure 2F. As disclosed above, the proximal anchor 203 and connecting members 206 may be cut from the same tube as the remainder of the structural frame 101 such that the structural frame 101, including the anchor 203 and connecting members 206, is a one piece unit. Alternatively, the anchor 203 and connecting members 206 may be separate units crimped or suitably attached to the structural frame 101 at the proximal collar 108.

The materials for the structural frame 101 should exhibit excellent corrosion resistance and biocompatibility.
In addition, the material comprising the structural frame 101 should be sufficiently radiopaque and create minimal artifacts during MRI.

The present invention contemplates deployment of the prosthetic venous valve 100 by both assisted (mechanical) expansion, i.e. balloon expansion, and self-expansion means.

In embodiments where the prosthetic venous valve 100 is deployed by mechanical (balloon) expansion, the structural frames 101 is made from materials that can be plastically deformed through the expansion of a mechanical assist device, such as by the inflation of a catheter based balloon. When the balloon is deflated, the frame 101 remains substantially in the expanded shape. Accordingly, the ideal material has a low yield stress (to make the frame 101 deformable at manageable balloon pressures), high elastic modulus (for minimal recoil), and is work hardened through expansion for high strength. The most widely used material for balloon expandable structures 101 is stainless steel, particularly 316L stainless steel. This material is particularly corrosion resistant with a low carbon content and additions of molybdenum and niobium. Fully annealed, stainless steel is easily deformable.

Alternative materials for mechanically expandable structural frames 101 that maintain similar characteristics to stainless steel include tantalum, platinum alloys, niobium alloys, and cobalt alloys. In addition other materials, such as polymers and bioabsorbable polymers may be used for the structural frames 101.

Where the prosthetic venous valve 100 is self-expanding, the materials comprising the structural frame 101 should exhibit large elastic strains. A suitable material possessing this characteristic is Nitinol, a Nickel-Titanium alloy that can recover elastic deformations of up to 10 percent. This unusually large elastic range is commonly known as superelasticity.

The disclosure of various materials comprising the structural frame should not be construed as limiting the scope of the invention. One of ordinary skill in the art would understand that other material possessing similar characteristics may also be used in the construction of the prosthetic venous valve 100. For example, bioabsorbable polymers, such as polydioxanone may also be used.

Bioabsorbable materials absorb into the body after a period of time. The period of time for the structural frame 101 to absorb may vary, but is typically sufficient to allow adequate tissue growth at the implant location to adhere to and anchor the biocompatible membrane 102.

The structural frame 101 may be fabricated using several different methods. Typically, the structural frame 101 is constructed from sheet, wire (round or flat) or tubing, but the method of fabrication generally depends on the raw material form used.

The structural frame 101 can be formed from wire using convention wire forming techniques, such as coiling, braiding, or knitting. By welding the wire at specific locations a closed-cell structure may be created. This allows for continuous production, i.e. the components of the structural frame 101, such as the anchors, to be cut to length from a long wire mesh tube. The connecting members (i.e. 206, 105) may then be attached to the proximal and distal anchors (i.e. 203, 104 respectively), by welding or other suitable connecting means. When this fabrication method is used, the proximal collar 108 may also be crimped over the wire frame ends (i.e. connecting members, cantilever struts, and/or centering legs) to connect the individual members together. Alternatively, the wire ends may be attached to the proximal collar 108 by welding or other suitable connecting means.

Alternatively, some or all of the complete structural frame 101 may be cut from a solid wall tube or sheet of material. Laser cutting, water-jet cutting and photochemical etching are all methods that can be employed .to form the structural frame 101 from sheet and tube stock as are known in the art.

Referring to Figure 2A for example, the structural frame 101 (including the distal anchor 104, connecting members 105, cantilever valve struts 107 and proximal collar 108) may all be cut from a solid tube eliminating the need for welding or mechanically attaching individual components together. In this embodiment, the proximal collar 108 shown is the actual pre-cut solid wall tube (and remains in the pre-cut, pre-expansion size), while the remainder of the components comprising the structural frame 101 are shown in the expanded (deployed) position. As one of skill in the art would understand, the proximal collar 108 serves as a common termination point for the cantilever valve struts 107 and connecting members 105.

In other embodiments, the proximal anchor 203 or centering legs 210 may similarly be cut from the same solid wall tube as the remainder of the structural frame 101.

Alternatively, the connecting members 105 and cantilever valve struts 107 may be separate loose components, and tied to each other by the proximal collar-108. In this configuration, the proximal collar 108 acts as a connection point to connect or crimp down and hold the loose members in place. In other embodiments disclosed above, the centering legs 210, connecting members 206 and/or proximal anchor 203 may also be fabricated separate from the other structural frame 101 components, and similarly attached or crimped in place at the proximal collar 108.

As discussed above, the disclosure of various methods for constructing the structural frame 101 should not be construed as limiting the scope of the invention. One of ordinary skill in the art would understand that other construction methods may be employed to form the structural frame 101 of the prosthetic venous valve 100.

In one embodiment of the invention, the anchor 104 (and in other particular embodiments, proximal anchor 203) are stent-based structures. This configuration facilitates the percutaneous delivery of the prosthetic venous valve 100 through the vascular system in a compressed state. Once properly located, the stent-based venous valve 100 may be deployed to the expanded state.

A perspective views of a typical stent-based anchor in the expanded (deployed) state is shown in Figures 3A.
Although stent anchor 104 incorporating a plurality of hoop structures (306A through 306D) is shown in the illustrated embodiment, each stent anchor may utilize a single hoop structure.

The distal stent anchor 104 (and in some embodiments proximal stent anchor 203) is comprised of a tubular configuration of structural elements having proximal and distal open ends and defining the longitudinal axis 106 extending therebetween. The stent anchor 104 has a first diameter (not shown) for insertion into a patient and navigation through the vessels, and a second diameter D2 for deployment into the target area of a vessel, with the second diameter being greater than the first diameter. The stent anchor 104, and thus the stent based venous valve 100, may be either a mechanical (balloon) or self-expanding stent based structure.

The stent anchor 104 comprises at least one hoop structure 306 (306A through 306D are shown) extending between the proximal and distal ends. The hoop structure 306 includes. a plurality of longitudinally arranged strut members 308 and a plurality of loop members 310 connecting adjacent struts 308. Adjacent struts 308 are connected at opposite ends in a substantially S or Z shaped pattern so as to form a plurality of cells. The plurality of loops 310 have a substantially semi-circular configuration, having an inter radii 312 and outer radii 314, and are substantially symmetric about their centers. The inner and outer radii 312, 314 respectively, are shown in a close-up perspective view illustrated in Figure 3B.

In the illustrated embodiment, the distal stent anchor 104 comprises a plurality of bridge members 314 that connect adjacent hoops 306A through 306D. Each bridge member 314 comprises two ends 316A, 316B. One end 316A, '316B of each bridge 314 is attached to one loop on one hoop. Using hoop sections 3060 and 306D for example, each bridge member 314 is connected at end 316A to loop 310 on hoop section 3060 at a point 320. Similarly, the opposite end 316B of each bridge member 314 is connected to loop 310 on hoop sections 306D at a point 321.

As described earlier, although a Z or S shaped pattern stent anchor is shown for the purpose of example, the illustration is not to be construed as limiting the scope of the invention. One of ordinary skill in the art would understand that other stent geometries may be used.

The connecting member 105 may be connected to the distal anchor 104 at various points along the structure. As illustrated in Figure 3A, the connecting members 105 are connected to the proximal end of the distal anchor 104 at the inflection point of the loop members 310, particularly at the outer radii 314 of the inflection point of loop members 310. Similarly, Figure 3C illustrates a single hoop anchor 104 having three connecting members 105 connected to the proximal end of the distal anchor 104 at the outer radii 314 of the inflection point of loop members 310.

Preferably the connecting members 105 are connected to the inflection point of loop members 310 at evenly spaced intervals along the circumference of the tubular anchor 104.
This configuration facilitates the radial expansion of the prosthetic valve from the collapsed (delivered) state to the expanded (deployed) state, and provides a substantially symmetrical valve configuration.

Alternatively, the connecting members 105 may be connected to the proximal end of the distal anchor 104 at the inner radii 312 of the inflection point of loop member 310. This configuration is illustrated in Figure 3D.
Figure 3D also illustrates a partial perspective view of the structural frame 101 having a single hoop structure 306 and three connecting members.

In still a further embodiment, the connecting members 105 may be connected along the strut members 308 of the distal anchor 104 as shown in Figure 3E.

In any of the above described configurations, the connections between the connecting members 105 and the anchor 104 may be made at every inflection point around the circumference of the structure; or alternatively, at a subset of the inflection points around the circumference of the structure. In other words, connected inflection points alternate with unconnected inflection points in some defined pattern.

The distal anchor 104 secures the prosthetic valve 100 to the inside wall of a body vessel such as a vein, and provide anchor points for the connecting members 105. Once deployed in the desired location, the anchor 104 will expand to an outside diameter slightly larger that the inside diameter of the native vessel (not shown) and remain substantially rigid in place, anchoring the valve assembly to the vessel. The connecting members 105 preferably have an inferior radial stiffness, and will conform much more closely to the native diameter of the vessel, facilitating ,the operation and stability of the prosthetic valve 100.

The stent anchor may also have spurs or barbs (not shown) protruding from its proximal or distal end to further assist anchoring the prosthetic valve.

The membrane assembly 102 is formed from a flexible membrane-like biocompatible material shaped into a tubular structure with a closed or substantially closed end.

Exemplary embodiments would include a cup or cone shaped tube. The flexible membrane may be elastic, semi-elastic or display little or no elasticity. One of skill in the art would appreciate that there are many different methods, some known in the art, which may be employed to manufacture the membrane assembly 102 from this material.

The biocompatible material may be a biological material, such as a vein or small intestine submucosa (SIS) formed into a cup or pocket, but is preferably a synthetic material such as a polymer, for example an elastic or elastomeric polymer, including a fluoropolymer, fluoroelastomer, or a bioabsorbable material, such as a bioabsorbable polymer or bioabsorbable elastomer.
Bioabsorbable materials may allow cells to grow and form a tissue membrane over the bioabsorbable membrane. The bioabsorbable membrane then absorbs into the body, leaving the tissue membrane in place to act as a new natural tissue valve.

The membrane material may also be made from other synthetics, such as thin metallic materials or membranes.

The membrane must be strong enough to resist tearing under normal use, yet thin enough to provide the necessary flexibility that allows the biocompatible membrane assembly 102 to open and close satisfactorily. To achieve the necessary flexibility and strength of the membrane assembly 102, the synthetic material may be, for example, reinforced with a fiber, such as an electro-statically spun (ESS) fiber, or formed from a porous foam, such as ePTFE, or a mesh.

Particular ESS fibers suitable for the spinning process include fluoropolymers, such as a crystalline fluoropolymer with an 85/15% (weight/weight ratio) of vinylidene fluoride/hexafluoropropylene (VDF/HFP). Solvay Solef 21508 and Kynarflex 2750-01 are two such examples. However, one of skill in the art would understand that any material possessing the desired characteristics may be used, including, for example: bioabsorbable polymers, such as polyglycolic acid, polylactic acid, poly (paradioxanone), polycaprolactone, poly (trimethylenecarbonate) and their copolymers; and semicrystalline bioelastomers, such as 60/40%(weight/weight ratio) of polylactic acid /

polycaprolactone (PLA/PCL), 65/35 (weight/weight ratio) of polyglycolic acid/polycaprolactone (PGA/PCL), or nonabsorbable siliconized polyurethane, non-siliconized polyurethanes, siliconized polyureaurethane, including siliconized polyureaurethane end capped with silicone or fluorine end groups, or natural, polymers in combination thereof. it should be noted that poly(trimethylenecarbonate) can not be spun as a homopolymer.

The ESS formed membrane assembly 102 may also be coated with a polymer solution, such as fluoroelastomer. The coating process may take place before the membrane assembly is attached to the cantilever valve struts 107 or connecting members 105, or after the membrane assembly 102 and structural frame 101 are assembled.

The coating process may act to encapsulate and attach at least a portion of the spun ESS reinforcement fiber to the structural frame, in particular the cantilever valve strut 107 assembly or connecting members 105. It should be noted that in some embodiments of the invention, some movement between the membrane assembly 102 and the structural frame 101 is desired. Accordingly, not all of the ESS fiber spun structural frame 101 may be coated.

The coating process may also remove some porosity of the membrane material. However, it may be desirable to maintain some porosity in particular embodiments to promote biological cell grown on and within the membrane tubular structure.

The coating solution preferably comprises a polymer put into solution with a solvent. As the solvent evaporates, the polymer comes out of solution forming the coating layer.
Accordingly, for the process to work properly, the solvent used in the coating solution should not dissolve or alter the ESS fibers being coated. By way of example, a coating solution of 60/40% VDF/HFP in methanol (methanol being the solvent) has been found to be a suitable solution for coating an ESS fiber comprised of 85/15% VDF/HFP.

In one embodiment of the invention, the polymer comprising the coating is Daikin's Dai-El G701BP, which is a 60/40% VDF/HFP. In addition, Daikin's Dai-El T630, a thermoplastic elastomer based on vinylidene fluoride/hexafluoropropylene/tetrafluoroethylene.

,(VDF/HFP/TFE) can also be used. Again, one of ordinary skill in the art would understand that other materials having suitable characteristics may be used for the coating, for example, other polymers, such as siliconized polyurethane, including Polymer Technology Group's Pursil, Carbosil, Purspan and Purspan F.

In another embodiment the membrane assembly is made from a micro-cellular foam or porous material, such as, for example an ePTFE membrane.

In this embodiment, the membrane assembly 102 is fabricated from a polymer material that can be processed such that it exhibits an expanded cellular structure, preferably expanded Polytetrafluoroethylene (ePTFE). The ePTFE tubing is made by expanding Polytetrafluoroethylene (PTFE) tubing, under controlled conditions, as is well known in the art. This process alters the physical properties that make it satisfactory for use in medical devices.
However, one of ordinary skill in the art would understand that other materials that possess the necessary characteristics could also be used.

The micro-cellular foam or porous material (preferably expanded Polytetrafluoroethylene (ePTFE)) may be coated with a polymer. The polymer can be coated on the inside or outside surface of the ePTFE tube. Alternatively, the polymer may be coated on the inside and outside of the ePTFE
tube.

In a preferred embodiment of the invention, the polymer comprising the coating includes. Daikin's Dai-El T630, a thermoplastic elastomer based on vinylidene fluoride/hexafluoropropylene/tetrafluoroethylene (VDF/HFP/TFE) and blends thereof. Again, one of ordinary skill in the art would understand that other materials having suitable characteristics may be used for the coating, for example, other polymers, such as siliconized polyurethanes and blends thereof, including Polymer Technology Group's Pursil, Carbosil, Purspan and Purspan F.

The membrane assembly 102 formed from the micro-cellular foam or porous membrane may also be coated with a fluoroelastomer. In one embodiment of the invention, the coating is Daikin G701BP, which is a 60/40% VDF/HFP. Again, one of ordinary skill in the art would understand that other materials having suitable characteristics might be used for the coating, for example, other polymers, such as siliconized polyurethane.

As previously described, the coating process may take place before the membrane assembly is attached to the structural frame 101, or after the membrane assembly 102 and structural frame 101 are assembled. The coating process may act to encapsulate and attach at least a portion of the micro-cellular foam or porous membrane tube to the structural frame 101.

Some post processing of the membrane assembly 102 may also take place to achieve particular desired characteristics or configurations. This may includes creating-the final closed or substantially closed cup or cone shape of the membrane assembly 102 if needed. In addition, post processing may change the characteristics of the membrane assembly 102 by thickening or thinning the membrane in particular locations. Thickening the membrane may add rigidity and reinforcement to a particular area.

Thinning the membrane may make the membrane more pliable, which is a desirable characteristic. Still other post processing procedures may change the physical shape of the membrane assembly 102, for example, by forming loop collars (such as loop collars 605 in Figures 6A through6C) along the distal edge of membrane assembly 102.

The thickness of the synthetic valve membrane assembly 102 is dependent on the size, type and location of the prosthetic valve. For venous valves applications a polymeric membrane assembly 102 having a thickness of between 12 m and 100pm and preferably between 25pm and 50pm has been found to be acceptable.

The membrane assembly 102 is placed or formed over the structural frame 101, similar to a graft. In particular, the membrane assembly 102 is formed into a closed end or substantially closed end tube over at least a portion of the connecting members 105. The cantilever valve struts 107 are then placed over the outer surface of the membrane assembly 102. The connecting members 105 and the cantilever valve struts 107 act to support the membrane assembly in a substantially tubular configuration.

The membrane assembly 102 may be formed into the tubular configuration separately, and then placed over the structural frame 101. Alternatively, the membrane assembly 102 may be. formed into the tubular configuration directly over the structural frame 101, such as by an electrostatic spinning process that spins the ESS fiber directly over the structural frame. This process is disclosed in a co pending patent application, serial number 10/402,048 entitled METHOD
OF FORMING A TUBULAR MEMBRANE ON A STRUCTURAL FRAME, filed on March 28, 2004, and is hereby incorporated by reference.

Figures 4A and 4B are perspective and section views, respectively, illustrating one embodiment of the expanded (deployed) prosthetic venous valve assembly 100 in the open position. In this embodiment, the term open means that the prosthetic venous valve 100 is configured to allow antegrade .blood flow 400 to pass through the valve. To accomplish this, the membrane assembly 102 is in a substantially collapsed position.

The embodiment illustrated in Figures 4A and 4B has three connecting members 105 and three cantilever valve struts 107. The membrane assembly 102 is placed over a portion of the structural frame 101, particularly over the connecting members 105, proximal collar 108 and at least a portion of the loop end 112 of the cantilever valve struts 107. A compression ring 109 may be used to fix the membrane assembly 102 to the proximal collar 108. The ring. 109 should be sized to apply a radially compressive force on the membrane assembly 102, effectively fixing the membrane assembly 102 against the proximal collar 108.

The flexible membrane assembly illustrated in Figure 4A is formed into a tubular cone having a first (distal) and second (proximal) ends 401, 402 respectively. The. first end 401 of the membrane assembly 102 is located at the distal end of the cantilever valve struts 107, near the proximal end of the distal anchor 104, and is capable of opening to substantially the full diameter of the native vessel. In one embodiment of the invention, the membrane assembly 102 is fixedly attached along the distal end of the cantilever valve struts 107 and connecting members 105. Alternatively the membrane assembly 102 may be slidably attached to the connecting members 105. This configuration may assist the membrane assembly 102 when opening and closing.

The membrane assembly extends in a proximal direction along the connecting members 105 and terminates at the second end 402. The second (proximal) end 402 of the membrane assembly 102 is fixedly or slideably attached along the loop end 112 of the cantilever valve struts 107. The proximal end 402 of the membrane assembly 102 has an open end with a substantially reduced cross-sectional area. As previously disclosed, the proximal end 402 may alternatively terminate with a closed cup or cone end.

In an alternative embodiment, the proximal end 402 may terminate at the proximal collar 108 with a closed or open end.

The illustrated embodiment shows a valve assembly 100 having a single cone or cup, and may be considered a monocusp design. However, other configurations using more than a single cup or cone are also contemplated by the present invention.

During retrograde flow, blood passes the leading edge along the first end 401 of the membrane assembly 102 and enters the interior (i.e. "cup") portion of membrane .assembly 102. The membrane assembly 102 quickly fills with the retrograde flowing blood, expanding and opening the membrane assembly 102. As the membrane assembly 102 opens, the first end 401 is forced out toward vessel wall, substantially occluding the vessel and thus reducing retrograde flow through the valve. In a preferred embodiment, the membrane assembly 102 will expand to a sufficient diameter to substantially seal against the inner vessel wall.

As previously described, the membrane assembly 102 may have a closed or substantially closed proximal end 402. In embodiments where the membrane assembly 102 proximal end 402 is substantially closed, the proximal opening must be of a sufficiently reduced cross-sectional area to substantially reduce or prevent the flow of fluid through the proximal end 402 of the membrane assembly 102.

In. the embodiment illustrated in Figure 4A, the proximal end 402 of the membrane assembly 102 is a substantially closed end tube (open but having a reduced cross-sectional area) disposed about the proximal loop end 112 of the cantilever valve struts 107. In particular, the proximal end 402 of the membrane assembly 102 is disposed about the cantilever valve strut 107 in close proximity to the interface between the cantilever valve strut 107 and proximal collar 108. The membrane assembly 102 and cantilever valve strut 107 are configured such that when the valve is in the open position (collapsed to allow blood flow to pass through the valve), the proximal loop ends 112 of the cantilever valve struts 107 are separated and allow the proximal end 402 of the membrane assembly to remain in an open tubular position. When the valve closes during retrograde blood flow, the proximal loop ends .112 of the cantilever valve struts 107 move closer together, urging the proximal end 402 of the membrane assembly 102 together.
This movement substantially or completely closes the proximal end 402 of the membrane assembly 102, allowing the membrane assembly to substantially or completely occlude the vessel.

Figures 5A and 5B show perspective and section views, respectively,' illustrating one embodiment of the expanded (deployed) prosthetic venous valve assembly 100 in the closed position. As the term is used herein, closed means that the prosthetic venous valve 100 is configured to substantially prohibit retrograde blood flow 410 to pass through the valve. To accomplish this, the membrane assembly 102 is in an expanded position, substantially occluding the vessel.

In a preferred embodiment of the invention, the membrane assembly 102 is normally configured in the open position (membrane assembly 102 substantially collapsed), and only moves to the closed position (membrane assembly 102 substantially expanded) upon retrograde blood flow. This configuration minimizes interference with blood flow (minimized occlusion) and reduces turbulence at and through the valve. The cantilever valve struts 107 in this embodiment have an inferior radial stiffness, and provide a natural bias against the movement of the membrane assembly 102 to the closed position. This bias assists the valve membrane assembly 102 when returning to the open position.
Depending on the application, it may also be desirable for the bias towards opening the prosthetic valve 100 (collapsing the membrane assembly 102) be sufficiently high to commence collapsing the membrane assembly 102 before antegrade blood flow begins, i.e. during a point in time when the blood flow is stagnant (there is neither antegrade nor retrograde blood flow), or when minimal retrograde flow is experienced.

In other applications, it may be desirable to have the valve assembly 100 normally configured in the closed position (membrane assembly 102 in the expanded position), biased closed, and only open upon antegrade flow.

As earlier described, the membrane assembly 102 is made from a flexible membrane-like biocompatible material. The membrane assembly 102 can be woven, non-woven (such as electrostatic spinning), mesh, knitted, film or porous film (such as foam).

The membrane assembly 102 may be fixedly attached to the structural frame 101 (particularly cantilever valve struts 107 and/or connecting members 105) by many different methods, including attachment by means of a binder, heat, or chemical bond, and/or attachment by mechanical means, such as welding or suturing. In one embodiment, some of the membrane assembly 102, such as distal end 401, is slideably attached to the connecting member 105. Allowing the distal end 401 to slide along the connecting member 105 107 may allow or improve the opening and closing of the membrane assembly 102. The sliding movement may also assist the membrane assembly 102 cup when filling and emptying.

In some applications, excessive sliding movement of the membrane assembly 102 is undesirable. In, these embodiments, a limiting means may be integrated into the prosthetic valve 100 to limit the sliding movement of the membrane assembly 102. Examples of limiting means are shown in Figures 6A to 6C. In each embodiment a stop 600 (illustrated as stop 600A, 600B, and 600C in Figures 6A to 6C respectively) is integrated into the connecting member 105. The membrane assembly 102 is wrapped around the connecting member 105 and bonded to itself to form a loop collar 605. The loop collar 605 must be sized to inhibit the distal end 401 of the membrane assembly 102 from, sliding past the stop 600. In Figure 6A, the connecting member 105 has a thickened or "bulbous" section forming stop 600A. Figure 6B illustrates an undulating stop 600B configuration. Similarly, Figure 6C

shows the stop 600C configured as a double bulbous section.
It should be noted that the various configurations illustrated in Figures 6A through 6C are exemplary. One of ordinary skill in the art would understand that other configurations of stops may used.

It is important to note that the local delivery of drug/drug combinations may be utilized to treat a wide variety of conditions utilizing any number of medical devices, or to enhance the function and/or life of the device. Medical devices that may benefit from this treatment include, for example, the frame based unidirectional flow prosthetic implant subject of the present invention.

Accordingly, in addition to the embodiments described above, therapeutic or pharmaceutic agents may be added to any component of the device during fabrication, including, for example, the ESS fiber, polymer or coating solution, membrane tube, structural frame or inner and outer membrane, to treat any. number of conditions. In addition, therapeutic or pharmaceutic agents may be applied to the device, such as in the form of a drug or drug eluting layer, or surface treatment after the device has been formed. In a preferred embodiment, the therapeutic and pharmaceutic agents may include any one or more of the following:
antiproliferative/antimitotic agents including natural products such as vinca alkaloids (i.e. vinblastine, vincristine, and vinorelbine), paclitaxel, epidipodophyllotoxins (i.e. etoposide, teniposide), antibiotics (dactinomycin (actinomycin D) daunorubicin, doxorubicin and idarubicin), anthracyclines, mitoxantrone, bleomycins, plicamycin (mithramycin) and mitomycin, enzymes (L-asparaginase which systemically metabolizes L-asparagine and deprives cells which do not have the capacity to synthesize their own asparagine) ; antiplatelet agents such as G(GP) llb/llla inhibitors and vitronectin receptor antagonists; antiproliferative/antimitotic alkylating agents such as nitrogen mustards (mechlorethamine, cyclophosphamide and analogs, melphalan, chlorambucil), ethylenimines and methylmelamines (hexamethylmelamine and thiotepa), alkyl sulfonates-busulfan, nirtosoureas (carmustine (BCNU) and analogs, streptozocin), trazenes dacarbazinine (DTIC); antiproliferative/antimitotic antimetabolites such as folic acid analogs (methotrexate), pyrimidine analogs (fluorouracil, floxuridine, and cytarabine), purine analogs and related inhibitors .20 (mercaptopurine, thioguanine, pentostatin and 2-chlorodeoxyadenosine {cladribine}); platinum coordination complexes (cisplatin, carbo'platin), procarbazine, hydroxyurea, mitotane, aminoglutethimide; hormones (i.e.

estrogen); anticoagulants (heparin, synthetic heparin salts and other inhibitors of thrombin); fibrinolytic agents (such as tissue plasminogen activator, streptokinase and urokinase), aspirin, dipyridamole, ticlopidine, clopidogrel, abciximab; antimigratory; antisecretory (breveldin); anti-inflammatory: such as adrenocortical steroids (cortisol, cortisone, fludrocortisone, prednisone, prednisolone, 6(G-methylprednisolone, triamcinolone, betamethasone, and dexamethasone), non-steroidal agents (salicylic acid derivatives i.e. aspirin; para-aminophenol derivatives i.e.
acetominophen; indole and indene acetic acids (indomethacin, sulindac, and etodalac) , heteroaryl acetic acids (tolmetin, diclofenac, and ketorolac), arylpropionic acids (ibuprofen and derivatives), anthranilic acids (mefenamic acid, and meclofenamic acid), enolic acids (piroxicam, tenoxicam, phenylbutazone, and oxyphenthatrazone), nabumetone, gold.
compounds (auranofin, aurothioglucose, gold sodium thiomalate); immunosuppressives: (cyclosporine, tacrolimus (FK-506), sirolimus (rapamycin), azathioprine, mycophenolate mofetil); angiogenic agents: vascular endothelial .growth factor (VEGF), fibroblast growth factor (FGF); angiotensin receptor blockers; nitric oxide donors; anti-sense oligionucleotides and combinations thereof; cell cycle inhibitors, mTOR inhibitors, and growth factor receptor signal transduction kinase inhibitors; retenoids; cyclin/CDK
inhibitors; HMG co-enzyme reductase inhibitors (statins);
and protease inhibitors.

While a number of variations of the invention have been shown and described in detail, other modifications and methods of use contemplated within the scope of this invention will be readily apparent to those of skill in the art based upon this disclosure. It is contemplated that various combinations or subcombinations of the specific embodiments may be made and still fall within the scope of the invention. For example, the embodiments variously shown to be prosthetic "venous valves" may be modified to instead incorporate prosthetic "heart valves" and are also contemplated. Moreover, all assemblies described are believed useful when modified to treat other vessels or lumens in the body, in particular other regions of the body where fluid flow in a body vessel or lumen needs to be controlled or regulated. This may include, for example, the coronary, vascular, non-vascular and peripheral vessels and ducts. Accordingly, it should be understood that various applications, modifications and substitutions may be made of equivalents without departing from the spirit of the invention or the scope of the following claims.

The following claims are provided to illustrate examples of some beneficial aspects of the subject matter disclosed herein which are within the scope of the present invention.

Claims (33)

1. A prosthetic valve comprising:
a radially expandable structural frame defining a longitudinal axis, including an anchor structure having first and second open ends, a connecting member having first and second ends, the first end of the connecting member being attached to the second end of the anchor structure, and a cantilever valve strut having first and a second ends, the first end of the cantilever valve strut being cooperatively associated with the second end of the connecting member; and a biocompatible membrane assembly having a substantially tubular configuration disposed longitudinally about the structural frame, the membrane assembly including a first end having a first diameter and a second end having a second diameter, wherein the first diameter is greater than the second diameter, the first end of the membrane assembly being attached along the second end of the cantilever valve strut, wherein the structural frame comprises a proximal collar attached to the second end of the connecting member and first end of the cantilever valve strut.
2. The prosthetic valve of claim 1 wherein the anchor structure is formed from a lattice of interconnected elements, and has a substantially cylindrical configuration.
3. The prosthetic valve of claim 1 wherein the structural frame comprises a material selected from the group consisting of stainless steel, tantalum, platinum alloys, niobium alloy, cobalt alloy, and nickeltitanium alloy.
4. The prosthetic valve of claim 1 wherein the structural frame comprises a polymer.
5. The prosthetic valve of claim 1 wherein the biocompatible membrane assembly is formed from a flexible membrane-like material.
6. The prosthetic valve of claim 5 wherein the membrane-like material is a biological material.
7. The prosthetic valve of claim 6 wherein the biological material is a vein.
8. The prosthetic valve of claim 5 wherein the membrane-like material is a synthetic material.
9. The prosthetic valve of claim 8 wherein the synthetic material is an elastomeric polymer.
10. The prosthetic valve of claim 8 wherein the synthetic material is a bioabsorbable material.
11. The prosthetic valve of claim 8 wherein the synthetic material further comprises a reinforcement fiber.
12. The prosthetic valve of claim 1 wherein at least a portion of the structural frame is coated with an agent.
13. The prosthetic valve of claim 12 wherein the agent coating contains a therapeutic agent.
14. The prosthetic valve of claim 12 wherein the agent coating contains a pharmaceutic agent.
15. The prosthetic valve of claim 12 wherein the agent coating comprises an agent-eluting layer.
16. The prosthetic valve of claim 1 wherein at least a portion of the membrane assembly is coated with an agent.
17. The prosthetic valve of claim 16 wherein the agent coating contains a therapeutic agent.
18. The prosthetic valve of claim 16 wherein the agent coating contains a pharmaceutic agent.
19. The prosthetic valve of claim 16 wherein the agent coating comprising an agent-eluting layer.
20. The prosthetic valve of claim 1 wherein at least a portion of the membrane assembly is impregnated with a therapeutic agent.
21. The prosthetic valve of claim 1 wherein at least a portion of the membrane assembly is impregnated with a pharmaceutic agent.
22. The prosthetic valve of claim 1 wherein the connecting member is a substantially straight member oriented in a direction substantially parallel to the longitudinal axis.
23. The prosthetic valve of claim 1 wherein the connecting member has a substantially helical shape about the longitudinal axis.
24. The prosthetic valve of claim 1 wherein the second end of the cantilever valve strut has a substantially straight shape and oriented in a direction substantially parallel to the longitudinal axis.
25. The prosthetic valve of claim 1 wherein the second end of the cantilever valve strut has a substantially helical shape about the longitudinal axis.
26. The prosthetic valve of claim 1 wherein the second end of the cantilever valve strut has a substantially sinusoidal shape oriented in a direction substantially parallel to the longitudinal axis.
27. The prosthetic valve of claim 1 wherein the second end of the tubular biocompatible membrane has a closed end.
28. The prosthetic valve of claim 1 wherein the second end of the tubular biocompatible membrane has an open end.
29. The prosthetic valve of claim 1 wherein the second end of the tubular biocompatible membrane moves from a substantially open to a substantially closed position by the cantilever valve strut.
30. The prosthetic valve of claim 1 wherein the first end of the cantilever valve strut is shaped into a semi-circular loop configuration.
31. The prosthetic valve of claim 1 wherein the structural frame further comprises a centering leg cooperatively associated with the proximal collar.
32. The prosthetic valve of claim 1 wherein the structural frame further comprises a proximal anchor cooperatively associated with the proximal collar.
33. The prosthetic valve of any of claims 1 to 32, wherein the biocompatible membrane assembly is disposed longitudinally about at least a portion of the connecting member.
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US10/699,014 US7070616B2 (en) 2003-10-31 2003-10-31 Implantable valvular prosthesis
PCT/US2004/034478 WO2005046529A1 (en) 2003-10-31 2004-10-18 Implantable valvular prosthesis

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Families Citing this family (315)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6006134A (en) 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
US7341598B2 (en) 1999-01-13 2008-03-11 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US7018406B2 (en) 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US8016877B2 (en) 1999-11-17 2011-09-13 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US7749245B2 (en) 2000-01-27 2010-07-06 Medtronic, Inc. Cardiac valve procedure methods and devices
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US8366769B2 (en) 2000-06-01 2013-02-05 Edwards Lifesciences Corporation Low-profile, pivotable heart valve sewing ring
WO2002005888A1 (en) 2000-06-30 2002-01-24 Viacor Incorporated Intravascular filter with debris entrapment mechanism
US6409758B2 (en) 2000-07-27 2002-06-25 Edwards Lifesciences Corporation Heart valve holder for constricting the valve commissures and methods of use
JP2004506469A (en) 2000-08-18 2004-03-04 アトリテック, インコーポレイテッド Expandable implantable device for filtering blood flow from the atrial appendage
US6602286B1 (en) 2000-10-26 2003-08-05 Ernst Peter Strecker Implantable valve system
US8038708B2 (en) 2001-02-05 2011-10-18 Cook Medical Technologies Llc Implantable device with remodelable material and covering material
US7544206B2 (en) 2001-06-29 2009-06-09 Medtronic, Inc. Method and apparatus for resecting and replacing an aortic valve
US8771302B2 (en) 2001-06-29 2014-07-08 Medtronic, Inc. Method and apparatus for resecting and replacing an aortic valve
US8623077B2 (en) 2001-06-29 2014-01-07 Medtronic, Inc. Apparatus for replacing a cardiac valve
FR2826863B1 (en) 2001-07-04 2003-09-26 Jacques Seguin ASSEMBLY FOR PLACING A PROSTHETIC VALVE IN A BODY CONDUIT
FR2828091B1 (en) 2001-07-31 2003-11-21 Seguin Jacques ASSEMBLY ALLOWING THE PLACEMENT OF A PROTHETIC VALVE IN A BODY DUCT
US7097659B2 (en) 2001-09-07 2006-08-29 Medtronic, Inc. Fixation band for affixing a prosthetic heart valve to tissue
US20060292206A1 (en) 2001-11-26 2006-12-28 Kim Steven W Devices and methods for treatment of vascular aneurysms
US7201771B2 (en) 2001-12-27 2007-04-10 Arbor Surgical Technologies, Inc. Bioprosthetic heart valve
US8308797B2 (en) 2002-01-04 2012-11-13 Colibri Heart Valve, LLC Percutaneously implantable replacement heart valve device and method of making same
US6752828B2 (en) 2002-04-03 2004-06-22 Scimed Life Systems, Inc. Artificial valve
US8721713B2 (en) 2002-04-23 2014-05-13 Medtronic, Inc. System for implanting a replacement valve
US7959674B2 (en) 2002-07-16 2011-06-14 Medtronic, Inc. Suture locking assembly and method of use
US7481821B2 (en) 2002-11-12 2009-01-27 Thomas J. Fogarty Embolization device and a method of using the same
US8551162B2 (en) 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
US6945957B2 (en) 2002-12-30 2005-09-20 Scimed Life Systems, Inc. Valve treatment catheter and methods
US20040260382A1 (en) 2003-02-12 2004-12-23 Fogarty Thomas J. Intravascular implants and methods of using the same
US7201772B2 (en) * 2003-07-08 2007-04-10 Ventor Technologies, Ltd. Fluid flow prosthetic device
BRPI0412362A (en) * 2003-07-08 2006-09-05 Ventor Technologies Ltd prosthetic implant devices particularly for transarterial transport in the treatment of aortic stenoses and implantation methods for such devices
US20050015110A1 (en) 2003-07-18 2005-01-20 Fogarty Thomas J. Embolization device and a method of using the same
US8021421B2 (en) 2003-08-22 2011-09-20 Medtronic, Inc. Prosthesis heart valve fixturing device
US9579194B2 (en) 2003-10-06 2017-02-28 Medtronic ATS Medical, Inc. Anchoring structure with concave landing zone
US7556647B2 (en) 2003-10-08 2009-07-07 Arbor Surgical Technologies, Inc. Attachment device and methods of using the same
US7854761B2 (en) 2003-12-19 2010-12-21 Boston Scientific Scimed, Inc. Methods for venous valve replacement with a catheter
US8128681B2 (en) 2003-12-19 2012-03-06 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US8579962B2 (en) 2003-12-23 2013-11-12 Sadra Medical, Inc. Methods and apparatus for performing valvuloplasty
US7748389B2 (en) 2003-12-23 2010-07-06 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US7445631B2 (en) 2003-12-23 2008-11-04 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US20050137694A1 (en) 2003-12-23 2005-06-23 Haug Ulrich R. Methods and apparatus for endovascularly replacing a patient's heart valve
US8287584B2 (en) 2005-11-14 2012-10-16 Sadra Medical, Inc. Medical implant deployment tool
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US9005273B2 (en) 2003-12-23 2015-04-14 Sadra Medical, Inc. Assessing the location and performance of replacement heart valves
US11278398B2 (en) 2003-12-23 2022-03-22 Boston Scientific Scimed, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US20050137686A1 (en) * 2003-12-23 2005-06-23 Sadra Medical, A Delaware Corporation Externally expandable heart valve anchor and method
US8343213B2 (en) 2003-12-23 2013-01-01 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US7381219B2 (en) 2003-12-23 2008-06-03 Sadra Medical, Inc. Low profile heart valve and delivery system
US20050137687A1 (en) * 2003-12-23 2005-06-23 Sadra Medical Heart valve anchor and method
US20120041550A1 (en) 2003-12-23 2012-02-16 Sadra Medical, Inc. Methods and Apparatus for Endovascular Heart Valve Replacement Comprising Tissue Grasping Elements
EP1702247B8 (en) 2003-12-23 2015-09-09 Boston Scientific Scimed, Inc. Repositionable heart valve
US8603160B2 (en) 2003-12-23 2013-12-10 Sadra Medical, Inc. Method of using a retrievable heart valve anchor with a sheath
US7824443B2 (en) 2003-12-23 2010-11-02 Sadra Medical, Inc. Medical implant delivery and deployment tool
US7780725B2 (en) 2004-06-16 2010-08-24 Sadra Medical, Inc. Everting heart valve
US8840663B2 (en) 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve method
US7329279B2 (en) 2003-12-23 2008-02-12 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8182528B2 (en) 2003-12-23 2012-05-22 Sadra Medical, Inc. Locking heart valve anchor
US8052749B2 (en) 2003-12-23 2011-11-08 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US7824442B2 (en) * 2003-12-23 2010-11-02 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US9526609B2 (en) 2003-12-23 2016-12-27 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US7871435B2 (en) 2004-01-23 2011-01-18 Edwards Lifesciences Corporation Anatomically approximate prosthetic mitral heart valve
CN101683291A (en) 2004-02-27 2010-03-31 奥尔特克斯公司 Prosthetic heart valve delivery systems and methods
ITTO20040135A1 (en) 2004-03-03 2004-06-03 Sorin Biomedica Cardio Spa CARDIAC VALVE PROSTHESIS
BRPI0510107A (en) 2004-04-23 2007-09-25 3F Therapeutics Inc implantable protein valve
EP1753369B1 (en) 2004-06-08 2013-05-29 Advanced Stent Technologies, Inc. Stent with protruding branch portion for bifurcated vessels
US7566343B2 (en) 2004-09-02 2009-07-28 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US20060052867A1 (en) 2004-09-07 2006-03-09 Medtronic, Inc Replacement prosthetic heart valve, system and method of implant
US8562672B2 (en) 2004-11-19 2013-10-22 Medtronic, Inc. Apparatus for treatment of cardiac valves and method of its manufacture
DE102005003632A1 (en) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Catheter for the transvascular implantation of heart valve prostheses
US20060173490A1 (en) 2005-02-01 2006-08-03 Boston Scientific Scimed, Inc. Filter system and method
US7854755B2 (en) 2005-02-01 2010-12-21 Boston Scientific Scimed, Inc. Vascular catheter, system, and method
US7670368B2 (en) 2005-02-07 2010-03-02 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US7780722B2 (en) 2005-02-07 2010-08-24 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US8574257B2 (en) 2005-02-10 2013-11-05 Edwards Lifesciences Corporation System, device, and method for providing access in a cardiovascular environment
ITTO20050074A1 (en) 2005-02-10 2006-08-11 Sorin Biomedica Cardio Srl CARDIAC VALVE PROSTHESIS
US7867274B2 (en) 2005-02-23 2011-01-11 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US7513909B2 (en) 2005-04-08 2009-04-07 Arbor Surgical Technologies, Inc. Two-piece prosthetic valves with snap-in connection and methods for use
US7722666B2 (en) 2005-04-15 2010-05-25 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US7962208B2 (en) 2005-04-25 2011-06-14 Cardiac Pacemakers, Inc. Method and apparatus for pacing during revascularization
US7914569B2 (en) 2005-05-13 2011-03-29 Medtronics Corevalve Llc Heart valve prosthesis and methods of manufacture and use
WO2010037038A2 (en) 2008-09-26 2010-04-01 Sonoma Orthopedic Products, Inc. Bone fixation device, tools and methods
US7909825B2 (en) 2006-11-22 2011-03-22 Sonoma Orthepedic Products, Inc. Fracture fixation device, tools and methods
US9060820B2 (en) 2005-05-18 2015-06-23 Sonoma Orthopedic Products, Inc. Segmented intramedullary fracture fixation devices and methods
US8961516B2 (en) 2005-05-18 2015-02-24 Sonoma Orthopedic Products, Inc. Straight intramedullary fracture fixation devices and methods
EP1885263A1 (en) 2005-05-18 2008-02-13 Sonoma Orthopaedic Products, Inc Minimally invasive actuable bone fixation devices, systems and methods of use
EP3292838A1 (en) 2005-05-24 2018-03-14 Edwards Lifesciences Corporation Rapid deployment prosthetic heart valve
US8211169B2 (en) 2005-05-27 2012-07-03 Medtronic, Inc. Gasket with collar for prosthetic heart valves and methods for using them
US8012198B2 (en) 2005-06-10 2011-09-06 Boston Scientific Scimed, Inc. Venous valve, system, and method
US7776084B2 (en) 2005-07-13 2010-08-17 Edwards Lifesciences Corporation Prosthetic mitral heart valve having a contoured sewing ring
US7712606B2 (en) 2005-09-13 2010-05-11 Sadra Medical, Inc. Two-part package for medical implant
US7569071B2 (en) 2005-09-21 2009-08-04 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US20070078510A1 (en) * 2005-09-26 2007-04-05 Ryan Timothy R Prosthetic cardiac and venous valves
US7540881B2 (en) 2005-12-22 2009-06-02 Boston Scientific Scimed, Inc. Bifurcation stent pattern
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US9078781B2 (en) 2006-01-11 2015-07-14 Medtronic, Inc. Sterile cover for compressible stents used in percutaneous device delivery systems
US7799038B2 (en) 2006-01-20 2010-09-21 Boston Scientific Scimed, Inc. Translumenal apparatus, system, and method
US7967857B2 (en) 2006-01-27 2011-06-28 Medtronic, Inc. Gasket with spring collar for prosthetic heart valves and methods for making and using them
WO2007097983A2 (en) 2006-02-14 2007-08-30 Sadra Medical, Inc. Systems and methods for delivering a medical implant
US8403981B2 (en) * 2006-02-27 2013-03-26 CardiacMC, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
US8147541B2 (en) 2006-02-27 2012-04-03 Aortx, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
US8075615B2 (en) 2006-03-28 2011-12-13 Medtronic, Inc. Prosthetic cardiac valve formed from pericardium material and methods of making same
US7318837B2 (en) * 2006-03-30 2008-01-15 Medtronic Vascular, Inc. Customized alloys for stents
US7740655B2 (en) 2006-04-06 2010-06-22 Medtronic Vascular, Inc. Reinforced surgical conduit for implantation of a stented valve therein
US7524331B2 (en) * 2006-04-06 2009-04-28 Medtronic Vascular, Inc. Catheter delivered valve having a barrier to provide an enhanced seal
US20070239269A1 (en) * 2006-04-07 2007-10-11 Medtronic Vascular, Inc. Stented Valve Having Dull Struts
WO2007130881A2 (en) 2006-04-29 2007-11-15 Arbor Surgical Technologies, Inc. Multiple component prosthetic heart valve assemblies and apparatus and methods for delivering them
US8021161B2 (en) 2006-05-01 2011-09-20 Edwards Lifesciences Corporation Simulated heart valve root for training and testing
US8932348B2 (en) 2006-05-18 2015-01-13 Edwards Lifesciences Corporation Device and method for improving heart valve function
US20070282429A1 (en) 2006-06-01 2007-12-06 Hauser David L Prosthetic insert for improving heart valve function
CN101505686A (en) 2006-06-20 2009-08-12 奥尔特克斯公司 Prosthetic heart valves, support structures and systems and methods for implanting the same
JP2009540952A (en) 2006-06-20 2009-11-26 エーオーテックス, インコーポレイテッド Torque shaft and torque drive
CA2657446A1 (en) 2006-06-21 2007-12-27 Aortx, Inc. Prosthetic valve implantation systems
CA2661959A1 (en) * 2006-09-06 2008-03-13 Aortx, Inc. Prosthetic heart valves, systems and methods of implanting
US8834564B2 (en) 2006-09-19 2014-09-16 Medtronic, Inc. Sinus-engaging valve fixation member
US11304800B2 (en) 2006-09-19 2022-04-19 Medtronic Ventor Technologies Ltd. Sinus-engaging valve fixation member
US8414643B2 (en) * 2006-09-19 2013-04-09 Medtronic Ventor Technologies Ltd. Sinus-engaging valve fixation member
US7951191B2 (en) 2006-10-10 2011-05-31 Boston Scientific Scimed, Inc. Bifurcated stent with entire circumferential petal
WO2008047354A2 (en) 2006-10-16 2008-04-24 Ventor Technologies Ltd. Transapical delivery system with ventriculo-arterial overflow bypass
US7842082B2 (en) 2006-11-16 2010-11-30 Boston Scientific Scimed, Inc. Bifurcated stent
WO2008070797A2 (en) 2006-12-06 2008-06-12 Medtronic Corevalve, Inc. System and method for transapical delivery of an annulus anchored self-expanding valve
US8133270B2 (en) 2007-01-08 2012-03-13 California Institute Of Technology In-situ formation of a valve
JP5313928B2 (en) 2007-02-05 2013-10-09 ボストン サイエンティフィック リミテッド Percutaneous valves and systems
US8623074B2 (en) 2007-02-16 2014-01-07 Medtronic, Inc. Delivery systems and methods of implantation for replacement prosthetic heart valves
US8221505B2 (en) * 2007-02-22 2012-07-17 Cook Medical Technologies Llc Prosthesis having a sleeve valve
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
FR2915087B1 (en) 2007-04-20 2021-11-26 Corevalve Inc IMPLANT FOR TREATMENT OF A HEART VALVE, IN PARTICULAR OF A MITRAL VALVE, EQUIPMENT INCLUDING THIS IMPLANT AND MATERIAL FOR PLACING THIS IMPLANT.
US7637940B2 (en) * 2007-07-06 2009-12-29 Boston Scientific Scimed, Inc. Stent with bioabsorbable membrane
US8828079B2 (en) 2007-07-26 2014-09-09 Boston Scientific Scimed, Inc. Circulatory valve, system and method
US8747458B2 (en) 2007-08-20 2014-06-10 Medtronic Ventor Technologies Ltd. Stent loading tool and method for use thereof
AU2008294012B2 (en) 2007-08-24 2013-04-18 St. Jude Medical, Inc. Prosthetic aortic heart valves
US7959669B2 (en) 2007-09-12 2011-06-14 Boston Scientific Scimed, Inc. Bifurcated stent with open ended side branch support
US10856970B2 (en) 2007-10-10 2020-12-08 Medtronic Ventor Technologies Ltd. Prosthetic heart valve for transfemoral delivery
US9848981B2 (en) 2007-10-12 2017-12-26 Mayo Foundation For Medical Education And Research Expandable valve prosthesis with sealing mechanism
US20090105813A1 (en) * 2007-10-17 2009-04-23 Sean Chambers Implantable valve device
US8216600B2 (en) * 2007-11-14 2012-07-10 Cordis Corporation Polymeric materials for medical devices
US8313526B2 (en) * 2007-11-19 2012-11-20 Cook Medical Technologies Llc Valve frame
US8057532B2 (en) * 2007-11-28 2011-11-15 Cook Medical Technologies Llc Implantable frame and valve design
US7833266B2 (en) 2007-11-28 2010-11-16 Boston Scientific Scimed, Inc. Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment
US8277501B2 (en) 2007-12-21 2012-10-02 Boston Scientific Scimed, Inc. Bi-stable bifurcated stent petal geometry
US7892276B2 (en) 2007-12-21 2011-02-22 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
WO2009086548A1 (en) * 2007-12-31 2009-07-09 C.R. Bard, Inc. Vascular graft prosthesis with selective flow reduction
US8211165B1 (en) 2008-01-08 2012-07-03 Cook Medical Technologies Llc Implantable device for placement in a vessel having a variable size
EP3572044B1 (en) 2008-01-24 2021-07-28 Medtronic, Inc. Stents for prosthetic heart valves
US9089422B2 (en) 2008-01-24 2015-07-28 Medtronic, Inc. Markers for prosthetic heart valves
US8157853B2 (en) 2008-01-24 2012-04-17 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
US9393115B2 (en) 2008-01-24 2016-07-19 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
US9149358B2 (en) 2008-01-24 2015-10-06 Medtronic, Inc. Delivery systems for prosthetic heart valves
US8628566B2 (en) 2008-01-24 2014-01-14 Medtronic, Inc. Stents for prosthetic heart valves
JP5203470B2 (en) * 2008-02-26 2013-06-05 イエナバルブ テクノロジー インク Stent for positioning and securing a valve prosthesis at a patient's heart implantation site
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
BR112012021347A2 (en) 2008-02-26 2019-09-24 Jenavalve Tecnology Inc stent for positioning and anchoring a valve prosthesis at an implantation site in a patient's heart
US20090264989A1 (en) 2008-02-28 2009-10-22 Philipp Bonhoeffer Prosthetic heart valve systems
US8696689B2 (en) * 2008-03-18 2014-04-15 Medtronic Ventor Technologies Ltd. Medical suturing device and method for use thereof
US8313525B2 (en) 2008-03-18 2012-11-20 Medtronic Ventor Technologies, Ltd. Valve suturing and implantation procedures
US8430927B2 (en) 2008-04-08 2013-04-30 Medtronic, Inc. Multiple orifice implantable heart valve and methods of implantation
US8312825B2 (en) 2008-04-23 2012-11-20 Medtronic, Inc. Methods and apparatuses for assembly of a pericardial prosthetic heart valve
US8696743B2 (en) 2008-04-23 2014-04-15 Medtronic, Inc. Tissue attachment devices and methods for prosthetic heart valves
EP2119417B2 (en) 2008-05-16 2020-04-29 Sorin Group Italia S.r.l. Atraumatic prosthetic heart valve prosthesis
US8932340B2 (en) 2008-05-29 2015-01-13 Boston Scientific Scimed, Inc. Bifurcated stent and delivery system
WO2009152273A1 (en) 2008-06-10 2009-12-17 Sonoma Orthopedic Products, Inc. Fracture fixation device, tools and methods
US8998981B2 (en) 2008-09-15 2015-04-07 Medtronic, Inc. Prosthetic heart valve having identifiers for aiding in radiographic positioning
US8721714B2 (en) 2008-09-17 2014-05-13 Medtronic Corevalve Llc Delivery system for deployment of medical devices
US20100082096A1 (en) * 2008-09-30 2010-04-01 Boston Scientific Scimed, Inc. Tailored Luminal & Abluminal Drug Elution
ES2409693T3 (en) 2008-10-10 2013-06-27 Sadra Medical, Inc. Medical devices and supply systems to supply medical devices
US8137398B2 (en) 2008-10-13 2012-03-20 Medtronic Ventor Technologies Ltd Prosthetic valve having tapered tip when compressed for delivery
US8449625B2 (en) 2009-10-27 2013-05-28 Edwards Lifesciences Corporation Methods of measuring heart valve annuluses for valve replacement
US8986361B2 (en) 2008-10-17 2015-03-24 Medtronic Corevalve, Inc. Delivery system for deployment of medical devices
US8308798B2 (en) 2008-12-19 2012-11-13 Edwards Lifesciences Corporation Quick-connect prosthetic heart valve and methods
EP2201911B1 (en) 2008-12-23 2015-09-30 Sorin Group Italia S.r.l. Expandable prosthetic valve having anchoring appendages
WO2010091223A1 (en) * 2009-02-06 2010-08-12 David Cheung Biphasic collagen membrane or capsule for guided tissue regeneration
US8348997B2 (en) * 2009-02-24 2013-01-08 Medtronic Vascular, Inc. One-way replacement valve
EP2413843B1 (en) 2009-03-30 2020-04-22 Suzhou Jiecheng Medical Technology Co. Ltd. Sutureless valve prostheses and devices for delivery
US9980818B2 (en) 2009-03-31 2018-05-29 Edwards Lifesciences Corporation Prosthetic heart valve system with positioning markers
EP2246011B1 (en) 2009-04-27 2014-09-03 Sorin Group Italia S.r.l. Prosthetic vascular conduit
US8348998B2 (en) 2009-06-26 2013-01-08 Edwards Lifesciences Corporation Unitary quick connect prosthetic heart valve and deployment system and methods
US8808369B2 (en) 2009-10-05 2014-08-19 Mayo Foundation For Medical Education And Research Minimally invasive aortic valve replacement
US9504562B2 (en) * 2010-01-12 2016-11-29 Valve Medical Ltd. Self-assembling modular percutaneous valve and methods of folding, assembly and delivery
US9226826B2 (en) 2010-02-24 2016-01-05 Medtronic, Inc. Transcatheter valve structure and methods for valve delivery
US8652204B2 (en) 2010-04-01 2014-02-18 Medtronic, Inc. Transcatheter valve with torsion spring fixation and related systems and methods
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
CN102883684B (en) 2010-05-10 2015-04-08 爱德华兹生命科学公司 Prosthetic heart valve
US9554901B2 (en) 2010-05-12 2017-01-31 Edwards Lifesciences Corporation Low gradient prosthetic heart valve
IT1400327B1 (en) 2010-05-21 2013-05-24 Sorin Biomedica Cardio Srl SUPPORT DEVICE FOR VALVULAR PROSTHESIS AND CORRESPONDING CORRESPONDENT.
CA2799459A1 (en) 2010-05-25 2011-12-01 Jenavalve Technology Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
CN103153384B (en) 2010-06-28 2016-03-09 科利柏心脏瓣膜有限责任公司 For the device of device in the delivery of vascular of chamber
WO2012018599A1 (en) * 2010-08-03 2012-02-09 Cook Medical Technologies Llc Two valve caval stent for functional replacement of incompetent tricuspid valve
US9918833B2 (en) 2010-09-01 2018-03-20 Medtronic Vascular Galway Prosthetic valve support structure
EP4119107A3 (en) 2010-09-10 2023-02-15 Boston Scientific Limited Valve replacement devices, delivery device for a valve replacement device and method of production of a valve replacement device
US8641757B2 (en) 2010-09-10 2014-02-04 Edwards Lifesciences Corporation Systems for rapidly deploying surgical heart valves
US9125741B2 (en) 2010-09-10 2015-09-08 Edwards Lifesciences Corporation Systems and methods for ensuring safe and rapid deployment of prosthetic heart valves
US9370418B2 (en) 2010-09-10 2016-06-21 Edwards Lifesciences Corporation Rapidly deployable surgical heart valves
US8845720B2 (en) 2010-09-27 2014-09-30 Edwards Lifesciences Corporation Prosthetic heart valve frame with flexible commissures
WO2012082952A2 (en) 2010-12-14 2012-06-21 Colibri Heart Valve Llc Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets
ES2641902T3 (en) 2011-02-14 2017-11-14 Sorin Group Italia S.R.L. Sutureless anchoring device for cardiac valve prostheses
EP2486894B1 (en) 2011-02-14 2021-06-09 Sorin Group Italia S.r.l. Sutureless anchoring device for cardiac valve prostheses
WO2012127309A1 (en) 2011-03-21 2012-09-27 Ontorfano Matteo Disk-based valve apparatus and method for the treatment of valve dysfunction
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
EP2520251A1 (en) 2011-05-05 2012-11-07 Symetis SA Method and Apparatus for Compressing Stent-Valves
US8945209B2 (en) 2011-05-20 2015-02-03 Edwards Lifesciences Corporation Encapsulated heart valve
CA2835893C (en) 2011-07-12 2019-03-19 Boston Scientific Scimed, Inc. Coupling system for medical devices
BR112014002174B1 (en) 2011-07-29 2020-12-01 University Of Pittsburgh Of The Commonwealth System Of Higher Education heart valve structure, multi-membrane heart valve structure and method for making a heart valve structure
US9668859B2 (en) 2011-08-05 2017-06-06 California Institute Of Technology Percutaneous heart valve delivery systems
US9131926B2 (en) 2011-11-10 2015-09-15 Boston Scientific Scimed, Inc. Direct connect flush system
US8940014B2 (en) 2011-11-15 2015-01-27 Boston Scientific Scimed, Inc. Bond between components of a medical device
US8951243B2 (en) 2011-12-03 2015-02-10 Boston Scientific Scimed, Inc. Medical device handle
US9510945B2 (en) 2011-12-20 2016-12-06 Boston Scientific Scimed Inc. Medical device handle
US9277993B2 (en) 2011-12-20 2016-03-08 Boston Scientific Scimed, Inc. Medical device delivery systems
US9078747B2 (en) 2011-12-21 2015-07-14 Edwards Lifesciences Corporation Anchoring device for replacing or repairing a heart valve
EP2609893B1 (en) 2011-12-29 2014-09-03 Sorin Group Italia S.r.l. A kit for implanting prosthetic vascular conduits
WO2013112547A1 (en) 2012-01-25 2013-08-01 Boston Scientific Scimed, Inc. Valve assembly with a bioabsorbable gasket and a replaceable valve implant
WO2013120082A1 (en) 2012-02-10 2013-08-15 Kassab Ghassan S Methods and uses of biological tissues for various stent and other medical applications
US9427315B2 (en) 2012-04-19 2016-08-30 Caisson Interventional, LLC Valve replacement systems and methods
US9011515B2 (en) 2012-04-19 2015-04-21 Caisson Interventional, LLC Heart valve assembly systems and methods
US9474605B2 (en) 2012-05-16 2016-10-25 Edwards Lifesciences Corporation Devices and methods for reducing cardiac valve regurgitation
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9883941B2 (en) 2012-06-19 2018-02-06 Boston Scientific Scimed, Inc. Replacement heart valve
US9629721B2 (en) * 2013-02-08 2017-04-25 Muffin Incorporated Peripheral sealing venous check-valve
AU2014214700B2 (en) 2013-02-11 2018-01-18 Cook Medical Technologies Llc Expandable support frame and medical device
EP4094725A1 (en) 2013-03-08 2022-11-30 Carnegie Mellon University Expandable implantable conduit
WO2014159447A2 (en) 2013-03-14 2014-10-02 Cardiovantage Medical, Inc. Embolic protection devices and methods of use
US11406497B2 (en) 2013-03-14 2022-08-09 Jc Medical, Inc. Heart valve prosthesis
US11259923B2 (en) 2013-03-14 2022-03-01 Jc Medical, Inc. Methods and devices for delivery of a prosthetic valve
US9744037B2 (en) 2013-03-15 2017-08-29 California Institute Of Technology Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves
US11007058B2 (en) 2013-03-15 2021-05-18 Edwards Lifesciences Corporation Valved aortic conduits
SG11201506352SA (en) 2013-03-15 2015-09-29 Edwards Lifesciences Corp Valved aortic conduits
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
EP2991586A1 (en) 2013-05-03 2016-03-09 Medtronic Inc. Valve delivery tool
US8870948B1 (en) 2013-07-17 2014-10-28 Cephea Valve Technologies, Inc. System and method for cardiac valve repair and replacement
CN109771100B (en) * 2013-07-22 2021-07-16 梅约医学教育与研究基金会 Device for self-centering a guide catheter
US9867694B2 (en) 2013-08-30 2018-01-16 Jenavalve Technology Inc. Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
SG11201508895RA (en) 2013-09-20 2015-11-27 Edwards Lifesciences Corp Heart valves with increased effective orifice area
US9421094B2 (en) 2013-10-23 2016-08-23 Caisson Interventional, LLC Methods and systems for heart valve therapy
US20150122687A1 (en) 2013-11-06 2015-05-07 Edwards Lifesciences Corporation Bioprosthetic heart valves having adaptive seals to minimize paravalvular leakage
US9770278B2 (en) 2014-01-17 2017-09-26 Arthrex, Inc. Dual tip guide wire
US9549816B2 (en) 2014-04-03 2017-01-24 Edwards Lifesciences Corporation Method for manufacturing high durability heart valve
US9974647B2 (en) 2014-06-12 2018-05-22 Caisson Interventional, LLC Two stage anchor and mitral valve assembly
USD867594S1 (en) 2015-06-19 2019-11-19 Edwards Lifesciences Corporation Prosthetic heart valve
CA2914094C (en) 2014-06-20 2021-01-05 Edwards Lifesciences Corporation Surgical heart valves identifiable post-implant
IL250181B1 (en) * 2014-07-20 2023-12-01 Bruckheimer Elchanan Pulmonary artery implant apparatus
US9814499B2 (en) 2014-09-30 2017-11-14 Arthrex, Inc. Intramedullary fracture fixation devices and methods
US9750605B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
US9750607B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
US9901445B2 (en) 2014-11-21 2018-02-27 Boston Scientific Scimed, Inc. Valve locking mechanism
US9693860B2 (en) * 2014-12-01 2017-07-04 Medtronic, Inc. Segmented transcatheter valve prosthesis having an unsupported valve segment
WO2016093877A1 (en) 2014-12-09 2016-06-16 Cephea Valve Technologies, Inc. Replacement cardiac valves and methods of use and manufacture
US10449043B2 (en) 2015-01-16 2019-10-22 Boston Scientific Scimed, Inc. Displacement based lock and release mechanism
US9861477B2 (en) 2015-01-26 2018-01-09 Boston Scientific Scimed Inc. Prosthetic heart valve square leaflet-leaflet stitch
US10201417B2 (en) 2015-02-03 2019-02-12 Boston Scientific Scimed Inc. Prosthetic heart valve having tubular seal
US9788942B2 (en) 2015-02-03 2017-10-17 Boston Scientific Scimed Inc. Prosthetic heart valve having tubular seal
US10426617B2 (en) 2015-03-06 2019-10-01 Boston Scientific Scimed, Inc. Low profile valve locking mechanism and commissure assembly
US10285809B2 (en) 2015-03-06 2019-05-14 Boston Scientific Scimed Inc. TAVI anchoring assist device
US10080652B2 (en) 2015-03-13 2018-09-25 Boston Scientific Scimed, Inc. Prosthetic heart valve having an improved tubular seal
US10286116B2 (en) 2015-04-15 2019-05-14 Mayo Foundation For Medical Education And Research Methods and materials for reducing venous neointimal hyperplasia of an arteriovenous fistula or graft
EP3288495B1 (en) 2015-05-01 2019-09-25 JenaValve Technology, Inc. Device with reduced pacemaker rate in heart valve replacement
EP4335415A2 (en) 2015-05-14 2024-03-13 Cephea Valve Technologies, Inc. Replacement mitral valves
WO2016183523A1 (en) 2015-05-14 2016-11-17 Cephea Valve Technologies, Inc. Cardiac valve delivery devices and systems
US10195392B2 (en) 2015-07-02 2019-02-05 Boston Scientific Scimed, Inc. Clip-on catheter
WO2017004377A1 (en) 2015-07-02 2017-01-05 Boston Scientific Scimed, Inc. Adjustable nosecone
US10136991B2 (en) 2015-08-12 2018-11-27 Boston Scientific Scimed Inc. Replacement heart valve implant
US10179041B2 (en) 2015-08-12 2019-01-15 Boston Scientific Scimed Icn. Pinless release mechanism
US10779940B2 (en) 2015-09-03 2020-09-22 Boston Scientific Scimed, Inc. Medical device handle
US10080653B2 (en) 2015-09-10 2018-09-25 Edwards Lifesciences Corporation Limited expansion heart valve
CA2998576A1 (en) 2015-10-13 2017-04-20 Venarum Medical, Llc Implantable valve and method
AU2016380345B2 (en) 2015-12-30 2021-10-28 Caisson Interventional, LLC Systems and methods for heart valve therapy
CN108882981B (en) 2016-01-29 2021-08-10 内奥瓦斯克迪亚拉公司 Prosthetic valve for preventing outflow obstruction
US10342660B2 (en) 2016-02-02 2019-07-09 Boston Scientific Inc. Tensioned sheathing aids
US11000370B2 (en) 2016-03-02 2021-05-11 Peca Labs, Inc. Expandable implantable conduit
US10667904B2 (en) 2016-03-08 2020-06-02 Edwards Lifesciences Corporation Valve implant with integrated sensor and transmitter
US10245136B2 (en) 2016-05-13 2019-04-02 Boston Scientific Scimed Inc. Containment vessel with implant sheathing guide
EP4183371A1 (en) 2016-05-13 2023-05-24 JenaValve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
US10583005B2 (en) 2016-05-13 2020-03-10 Boston Scientific Scimed, Inc. Medical device handle
US10201416B2 (en) 2016-05-16 2019-02-12 Boston Scientific Scimed, Inc. Replacement heart valve implant with invertible leaflets
US11331187B2 (en) 2016-06-17 2022-05-17 Cephea Valve Technologies, Inc. Cardiac valve delivery devices and systems
US11771434B2 (en) 2016-09-28 2023-10-03 Restore Medical Ltd. Artery medical apparatus and methods of use thereof
US10610357B2 (en) 2016-10-10 2020-04-07 Peca Labs, Inc. Transcatheter stent and valve assembly
DE202016105963U1 (en) * 2016-10-24 2018-01-25 Nvt Ag Intraluminal vascular prosthesis for implantation in the heart or cardiac vessels of a patient
WO2018090148A1 (en) 2016-11-21 2018-05-24 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
EP4209196A1 (en) 2017-01-23 2023-07-12 Cephea Valve Technologies, Inc. Replacement mitral valves
CA3051272C (en) 2017-01-23 2023-08-22 Cephea Valve Technologies, Inc. Replacement mitral valves
WO2018138658A1 (en) 2017-01-27 2018-08-02 Jenavalve Technology, Inc. Heart valve mimicry
CN110475526B (en) 2017-04-05 2022-02-08 波士顿科学国际有限公司 Bolt capturing centering device
US10463485B2 (en) 2017-04-06 2019-11-05 Edwards Lifesciences Corporation Prosthetic valve holders with automatic deploying mechanisms
CA3060663A1 (en) 2017-04-28 2018-11-01 Edwards Lifesciences Corporation Prosthetic heart valve with collapsible holder
EP3624704A4 (en) 2017-06-05 2021-03-10 Restore Medical Ltd Double walled fixed length stent like apparatus and methods of use thereof
WO2018226915A1 (en) 2017-06-08 2018-12-13 Boston Scientific Scimed, Inc. Heart valve implant commissure support structure
CN110831547B (en) 2017-06-21 2022-07-15 爱德华兹生命科学公司 Double-wire limited expansion heart valve
EP3661458A1 (en) 2017-08-01 2020-06-10 Boston Scientific Scimed, Inc. Medical implant locking mechanism
CN111225633B (en) 2017-08-16 2022-05-31 波士顿科学国际有限公司 Replacement heart valve coaptation assembly
US11141145B2 (en) 2017-08-25 2021-10-12 Edwards Lifesciences Corporation Devices and methods for securing a tissue anchor
WO2019036810A1 (en) 2017-08-25 2019-02-28 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
WO2019051476A1 (en) 2017-09-11 2019-03-14 Incubar, LLC Conduit vascular implant sealing device for reducing endoleak
EP3716907B1 (en) 2017-12-01 2023-06-07 C. R. Bard, Inc. Adjustable vascular graft for custom inner diameter reduction and related methods
US10799350B2 (en) 2018-01-05 2020-10-13 Edwards Lifesciences Corporation Percutaneous implant retrieval connector and method
CN210582753U (en) 2018-01-07 2020-05-22 苏州杰成医疗科技有限公司 Delivery system for delivering a valve prosthesis
CN211213690U (en) 2018-01-07 2020-08-11 苏州杰成医疗科技有限公司 Control unit for controlling a valve delivery device to deliver a valve prosthesis
JP7047106B2 (en) 2018-01-19 2022-04-04 ボストン サイエンティフィック サイムド,インコーポレイテッド Medical device delivery system with feedback loop
EP3740160A2 (en) 2018-01-19 2020-11-25 Boston Scientific Scimed Inc. Inductance mode deployment sensors for transcatheter valve system
EP3720389A1 (en) 2018-01-22 2020-10-14 Edwards Lifesciences Corporation Heart shape preserving anchor
US11147668B2 (en) 2018-02-07 2021-10-19 Boston Scientific Scimed, Inc. Medical device delivery system with alignment feature
WO2019165394A1 (en) 2018-02-26 2019-08-29 Boston Scientific Scimed, Inc. Embedded radiopaque marker in adaptive seal
WO2019222367A1 (en) 2018-05-15 2019-11-21 Boston Scientific Scimed, Inc. Replacement heart valve commissure assembly
WO2019224577A1 (en) 2018-05-23 2019-11-28 Sorin Group Italia S.R.L. A cardiac valve prosthesis
US11007061B2 (en) 2018-05-24 2021-05-18 Edwards Lifesciences Corporation Adjustable percutaneous heart valve repair system
US11241310B2 (en) 2018-06-13 2022-02-08 Boston Scientific Scimed, Inc. Replacement heart valve delivery device
US11737872B2 (en) 2018-11-08 2023-08-29 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
WO2020123486A1 (en) 2018-12-10 2020-06-18 Boston Scientific Scimed, Inc. Medical device delivery system including a resistance member
CA3135753C (en) 2019-04-01 2023-10-24 Neovasc Tiara Inc. Controllably deployable prosthetic valve
CA3136334A1 (en) 2019-04-10 2020-10-15 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
US11439504B2 (en) 2019-05-10 2022-09-13 Boston Scientific Scimed, Inc. Replacement heart valve with improved cusp washout and reduced loading
WO2020236931A1 (en) 2019-05-20 2020-11-26 Neovasc Tiara Inc. Introducer with hemostasis mechanism
CN114144144A (en) 2019-06-20 2022-03-04 内奥瓦斯克迪亚拉公司 Low-profile prosthetic mitral valve
EP4076284A1 (en) 2019-12-16 2022-10-26 Edwards Lifesciences Corporation Valve holder assembly with suture looping protection
JP2023544825A (en) * 2020-10-07 2023-10-25 ザ チルドレンズ メディカル センター コーポレーション Valve reconstruction workflow based on engineering design

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4892541A (en) * 1982-11-29 1990-01-09 Tascon Medical Technology Corporation Heart valve prosthesis
CH672247A5 (en) * 1986-03-06 1989-11-15 Mo Vysshee Tekhnicheskoe Uchil
US4790843A (en) * 1986-06-16 1988-12-13 Baxter Travenol Laboratories, Inc. Prosthetic heart valve assembly
US4725274A (en) * 1986-10-24 1988-02-16 Baxter Travenol Laboratories, Inc. Prosthetic heart valve
US5156621A (en) * 1988-03-22 1992-10-20 Navia Jose A Stentless bioprosthetic cardiac valve
US5032128A (en) * 1988-07-07 1991-07-16 Medtronic, Inc. Heart valve prosthesis
US4969896A (en) * 1989-02-01 1990-11-13 Interpore International Vascular graft prosthesis and method of making the same
DK0474748T3 (en) * 1989-05-31 1995-05-01 Baxter Int Biological flap prosthesis
US5609626A (en) * 1989-05-31 1997-03-11 Baxter International Inc. Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts
US5147391A (en) * 1990-04-11 1992-09-15 Carbomedics, Inc. Bioprosthetic heart valve with semi-permeable commissure posts and deformable leaflets
US5037434A (en) 1990-04-11 1991-08-06 Carbomedics, Inc. Bioprosthetic heart valve with elastic commissures
DK124690D0 (en) * 1990-05-18 1990-05-18 Henning Rud Andersen FAT PROTECTION FOR IMPLEMENTATION IN THE BODY FOR REPLACEMENT OF NATURAL FLEET AND CATS FOR USE IN IMPLEMENTING A SUCH FAT PROTECTION
US5411552A (en) * 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
GB9012716D0 (en) * 1990-06-07 1990-08-01 Frater Robert W M Mitral heart valve replacements
US5163955A (en) * 1991-01-24 1992-11-17 Autogenics Rapid assembly, concentric mating stent, tissue heart valve with enhanced clamping and tissue alignment
US5755782A (en) 1991-01-24 1998-05-26 Autogenics Stents for autologous tissue heart valve
US5489298A (en) * 1991-01-24 1996-02-06 Autogenics Rapid assembly concentric mating stent, tissue heart valve with enhanced clamping and tissue exposure
PL168894B1 (en) * 1991-05-08 1996-04-30 Nika Health Products Ltd Basa for a hearth valvula prosthesis
DK0583410T3 (en) * 1991-05-16 2001-11-12 Mures Cardiovascular Res Inc Heart valve
IT1247037B (en) * 1991-06-25 1994-12-12 Sante Camilli ARTIFICIAL VENOUS VALVE
US5876445A (en) * 1991-10-09 1999-03-02 Boston Scientific Corporation Medical stents for body lumens exhibiting peristaltic motion
US5123919A (en) * 1991-11-21 1992-06-23 Carbomedics, Inc. Combined prosthetic aortic heart valve and vascular graft
US5163953A (en) * 1992-02-10 1992-11-17 Vince Dennis J Toroidal artificial heart valve stent
US5258023A (en) * 1992-02-12 1993-11-02 Reger Medical Development, Inc. Prosthetic heart valve
US5449384A (en) * 1992-09-28 1995-09-12 Medtronic, Inc. Dynamic annulus heart valve employing preserved porcine valve leaflets
US5607463A (en) * 1993-03-30 1997-03-04 Medtronic, Inc. Intravascular medical device
DK0621015T3 (en) * 1993-04-23 1998-12-21 Schneider Europ Gmbh Stent but a cover layer of an elastic material as well as a method of applying this layer to the stent
GB9312666D0 (en) * 1993-06-18 1993-08-04 Vesely Ivan Bioprostetic heart valve
US5480424A (en) * 1993-11-01 1996-01-02 Cox; James L. Heart valve replacement using flexible tubes
EP0667133B1 (en) * 1993-12-14 2001-03-07 Sante Camilli A percutaneous implantable valve for the use in blood vessels
US5609627A (en) * 1994-02-09 1997-03-11 Boston Scientific Technology, Inc. Method for delivering a bifurcated endoluminal prosthesis
US5595571A (en) * 1994-04-18 1997-01-21 Hancock Jaffe Laboratories Biological material pre-fixation treatment
US5522885A (en) * 1994-05-05 1996-06-04 Autogenics Assembly tooling for an autologous tissue heart valve
US5554185A (en) * 1994-07-18 1996-09-10 Block; Peter C. Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same
US5562729A (en) * 1994-11-01 1996-10-08 Biocontrol Technology, Inc. Heart valve
US6124523A (en) * 1995-03-10 2000-09-26 Impra, Inc. Encapsulated stent
EP0831753B1 (en) * 1995-06-01 2005-12-28 Meadox Medicals, Inc. Implantable intraluminal prosthesis
US5728152A (en) * 1995-06-07 1998-03-17 St. Jude Medical, Inc. Bioresorbable heart valve support
AU6280396A (en) * 1995-06-20 1997-01-22 Efstathios A. Agathos Human valve replacement with marine mammal valve
EP0955933B1 (en) * 1995-10-13 2009-08-26 Medtronic Vascular, Inc. A device for interstitial transvascular intervention
US5855602A (en) * 1996-09-09 1999-01-05 Shelhigh, Inc. Heart valve prosthesis
US5861028A (en) * 1996-09-09 1999-01-19 Shelhigh Inc Natural tissue heart valve and stent prosthesis and method for making the same
JPH09185113A (en) * 1996-01-04 1997-07-15 Minolta Co Ltd Waterproof structure for camera
US6036687A (en) * 1996-03-05 2000-03-14 Vnus Medical Technologies, Inc. Method and apparatus for treating venous insufficiency
EP0808614B1 (en) 1996-05-23 2003-02-26 Samsung Electronics Co., Ltd. Flexible self-expandable stent and method for making the same
US5855601A (en) * 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
US6086610A (en) * 1996-10-22 2000-07-11 Nitinol Devices & Components Composite self expanding stent device having a restraining element
US6315791B1 (en) * 1996-12-03 2001-11-13 Atrium Medical Corporation Self-expanding prothesis
NL1004827C2 (en) * 1996-12-18 1998-06-19 Surgical Innovations Vof Device for regulating blood circulation.
US5851232A (en) * 1997-03-15 1998-12-22 Lois; William A. Venous stent
US5928281A (en) * 1997-03-27 1999-07-27 Baxter International Inc. Tissue heart valves
US5957949A (en) * 1997-05-01 1999-09-28 World Medical Manufacturing Corp. Percutaneous placement valve stent
US6245102B1 (en) * 1997-05-07 2001-06-12 Iowa-India Investments Company Ltd. Stent, stent graft and stent valve
US5855597A (en) * 1997-05-07 1999-01-05 Iowa-India Investments Co. Limited Stent valve and stent graft for percutaneous surgery
CA2235911C (en) * 1997-05-27 2003-07-29 Schneider (Usa) Inc. Stent and stent-graft for treating branched vessels
US6158614A (en) * 1997-07-30 2000-12-12 Kimberly-Clark Worldwide, Inc. Wet wipe dispenser with refill cartridge
US5910170A (en) * 1997-12-17 1999-06-08 St. Jude Medical, Inc. Prosthetic heart valve stent utilizing mounting clips
US6342067B1 (en) 1998-01-09 2002-01-29 Nitinol Development Corporation Intravascular stent having curved bridges for connecting adjacent hoops
ES2141071T1 (en) 1998-02-25 2000-03-16 Medtronic Ave Inc ASSEMBLY OF GRAFT AND INSERT AND METHOD OF MANUFACTURE.
US5935163A (en) * 1998-03-31 1999-08-10 Shelhigh, Inc. Natural tissue heart valve prosthesis
JP4399585B2 (en) * 1998-06-02 2010-01-20 クック インコーポレイティド Multi-sided medical device
US7128073B1 (en) * 1998-11-06 2006-10-31 Ev3 Endovascular, Inc. Method and device for left atrial appendage occlusion
JP2000192102A (en) * 1998-12-25 2000-07-11 Kawasaki Steel Corp Ferrous powdery mixture for powder metallurgy
FR2788217A1 (en) 1999-01-12 2000-07-13 Brice Letac PROSTHETIC VALVE IMPLANTABLE BY CATHETERISM, OR SURGICAL
US6425916B1 (en) 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
WO2000047136A1 (en) 1999-02-12 2000-08-17 Johns Hopkins University Venous valve implant bioprosthesis and endovascular treatment for venous insufficiency
US6283995B1 (en) * 1999-04-15 2001-09-04 Sulzer Carbomedics Inc. Heart valve leaflet with scalloped free margin
US6228112B1 (en) * 1999-05-14 2001-05-08 Jack Klootz Artificial heart valve without a hinge
US6296662B1 (en) 1999-05-26 2001-10-02 Sulzer Carbiomedics Inc. Bioprosthetic heart valve with balanced stent post deflection
US6299637B1 (en) * 1999-08-20 2001-10-09 Samuel M. Shaolian Transluminally implantable venous valve
US6440164B1 (en) * 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
US6458153B1 (en) * 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US6702834B1 (en) * 1999-12-30 2004-03-09 Advanced Cardiovascular Systems, Inc. Embolic protection devices
DK1255510T5 (en) * 2000-01-31 2009-12-21 Cook Biotech Inc Stent Valve Klapper
US6245100B1 (en) * 2000-02-01 2001-06-12 Cordis Corporation Method for making a self-expanding stent-graft
JP2001231868A (en) * 2000-02-25 2001-08-28 Arata Ishimaru Stent, stent graft, and stent composing member
AU2001245432B2 (en) * 2000-03-03 2006-04-27 Cook Medical Technologies Llc Bulbous valve and stent for treating vascular reflux
US6613082B2 (en) 2000-03-13 2003-09-02 Jun Yang Stent having cover with drug delivery capability
US7510572B2 (en) * 2000-09-12 2009-03-31 Shlomo Gabbay Implantation system for delivery of a heart valve prosthesis
US6511496B1 (en) * 2000-09-12 2003-01-28 Advanced Cardiovascular Systems, Inc. Embolic protection device for use in interventional procedures
US6746773B2 (en) 2000-09-29 2004-06-08 Ethicon, Inc. Coatings for medical devices
ATE343969T1 (en) * 2000-09-29 2006-11-15 Cordis Corp COATED MEDICAL DEVICES
US6494909B2 (en) * 2000-12-01 2002-12-17 Prodesco, Inc. Endovascular valve
US6582448B1 (en) * 2000-12-21 2003-06-24 Advanced Cardiovascular Systems, Inc. Vessel occlusion device for embolic protection system
US6503272B2 (en) * 2001-03-21 2003-01-07 Cordis Corporation Stent-based venous valves
US7179275B2 (en) * 2001-06-18 2007-02-20 Rex Medical, L.P. Vein filter
FR2828091B1 (en) * 2001-07-31 2003-11-21 Seguin Jacques ASSEMBLY ALLOWING THE PLACEMENT OF A PROTHETIC VALVE IN A BODY DUCT
US6790237B2 (en) * 2001-10-09 2004-09-14 Scimed Life Systems, Inc. Medical stent with a valve and related methods of manufacturing
WO2003079944A1 (en) * 2002-03-20 2003-10-02 Spiration, Inc. Removable anchored lung volume reduction devices and methods
JP4064724B2 (en) * 2002-05-20 2008-03-19 川澄化学工業株式会社 Stent and stent graft
US20040143342A1 (en) * 2003-01-16 2004-07-22 Stack Richard S. Satiation pouches and methods of use
US7163549B2 (en) * 2003-02-11 2007-01-16 Boston Scientific Scimed Inc. Filter membrane manufacturing method
US20040260331A1 (en) * 2003-06-20 2004-12-23 D'aquanni Peter Beta titanium embolic protection frame and guide wire
US20050049668A1 (en) * 2003-08-29 2005-03-03 Jones Donald K. Self-expanding stent and stent delivery system for treatment of vascular stenosis

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