CA2548357A1 - Composition comprising an aqueous extract of red vine leaves and a diuretic for the treatment of chronic venous insufficiences - Google Patents
Composition comprising an aqueous extract of red vine leaves and a diuretic for the treatment of chronic venous insufficiences Download PDFInfo
- Publication number
- CA2548357A1 CA2548357A1 CA002548357A CA2548357A CA2548357A1 CA 2548357 A1 CA2548357 A1 CA 2548357A1 CA 002548357 A CA002548357 A CA 002548357A CA 2548357 A CA2548357 A CA 2548357A CA 2548357 A1 CA2548357 A1 CA 2548357A1
- Authority
- CA
- Canada
- Prior art keywords
- red vine
- vine leaves
- aqueous extract
- extract
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
This invention relates to a new composition containing the effective dosage of an aqueous extract of red vine leaves (1) and a diuretic (2) for preventing or alleviating the discomfort associated with mild-to-moderate chronic venous insufficiency of the legs. The compositions according to this invention may also contain pharmaceutically or dietetically acceptable additives.
Description
COMPOSITION COMPRISING AN AQUEOUS EXTRACT OF RED VINE LEAVES AND A DIURETIC
FOR
THE TREATMENT OF CHRONIC VENOUS INSUFFICIENCES
BACK-GROUND OF THE INVENTION
1. Technical Field The invention relates to compositions comprising an effective dose of an aqueous extract of red vine leaves and a diuretic for preventing or alleviating mild-to-moderate chronic l0 venous insufficiency of the legs. The composition according to this invention also includes acceptable pharmaceutical or dietetic additives. In addition, the compositions according to this inventions decrease or prevent subjective symptoms such as lassitude (listlessness), heavy legs, tired legs, sensation of tension, and pain associated with swelling of calves and ankles due to disorder of leg venous flow.
FOR
THE TREATMENT OF CHRONIC VENOUS INSUFFICIENCES
BACK-GROUND OF THE INVENTION
1. Technical Field The invention relates to compositions comprising an effective dose of an aqueous extract of red vine leaves and a diuretic for preventing or alleviating mild-to-moderate chronic l0 venous insufficiency of the legs. The composition according to this invention also includes acceptable pharmaceutical or dietetic additives. In addition, the compositions according to this inventions decrease or prevent subjective symptoms such as lassitude (listlessness), heavy legs, tired legs, sensation of tension, and pain associated with swelling of calves and ankles due to disorder of leg venous flow.
2. Related Art Presently, there are millions of people around the world who suffer from mild-to-moderate chronic venous insufficiency of the legs. This common condition is characterized by an inadequacy of the venous circulation to return blood from the legs to the heart. The lack of 2o adequate venous return results in venous stasis and an increased pressure within the venous circulation, promoting the development of oedema and tissular water retention.
Chronic venous insufficiency (CVI) is a functional disorder caused by persistent inadequacy of the venous return and is characterized clinically by oedema, shin changes and subjective complaints such as tired, heavy legs, pain or tingling sensations, which are typically amplified by standing upright and by high ambient temperatures. This dysfunction may be a source of major distress with a significant negative impact on the patient's overall well-being and quality of life.
Early stages (grade I) are characterized by coronal phlebectasia parapiantaris, subfasciai congestion and oedema; grade II CVI is associated with low-grade skin changes, eczema and lipodermatosclerosis. If untreated, grades I and II often progress to an advanced stage characterized by recurrent venous leg ulcers (grade III). The stress caused by the symptoms, even when relatively mild initially, and the risk of later complications call for appropriate supportive and preventive measures to be initiated in the early stages of CVI.
Although some patients, even at early stages, might require surgery (sclerotherapy and variceal surgery), the use of compression stockings with or without additional physiotherapy is the most common treatment approach. The effect of compression is merely mechanical, i.e. this approach does not affect or correct the related biological dysfunction (capillary fragility in particular). Furthermore, the treatment with compression l0 stockings often lacks compliance because of cosmetic concerns and the overall inconvenience of the c~mpressive stockings, in the summer in particular.
Therefore there is an urgent need for alternative approaches that are effective, well-tolerated and more convenient.
This extract of red vine leaves contains flavon (ol) -glycosides, -glucuronides and flavonoids, with quercetin-3-O-beta-D-glucuronide and isoquercitrin (quercetin-3-O-beta-glucoside) as its main active ingredients. The range of their pharmacological actions has not yet been fully elucidated, but in-vitro studies indicate that they have antioxidant and anti-inflammatory properties and that they inhibit platelet aggregation and hyaluronidase and reduce oedema, possibly by reducing capillary permeability. Preclinical in-vivo experiments~demonstrated anti-inflammatory and capillary wall thickening effects.
Dietary supplements including an aqueous extract of red vine leaves are disclosed to prevent and reduce the discomfort relating to mild-to-moderate chronic venous insufficiency of the legs in WO 01128363. However, there are no hints to compositions comprising an aqueous extract of red vine leaves and other active ingredients such as diuretics given by WO 01/28363.
SHORT DESCRIPTION OF THE INVENTION
3o Surprisingly, potentiation of anti-inflammatory action and inhibitory action on oedema, indices of pharmacological activities of an aqueous extract of red vine leaves, is found by _2_ combination of a diuretic with an aqueous extract of red vine leaves comparing the action itself. Moreover, composing nuld diuretics resulted in safe compositions whose efficacy is potentiated for preventing and alleviating discomfort relating to mild-to-moderate chronic venous insufficiency of the legs with minimum or no adverse reactions. The new compositions comprising a diuretic and an aqueous extract of red vine leaves potentiate the efficacy of prevention or relaxation for mild-to-moderate chronic venous insufficiency of the legs.
Therefore, this invention relates to new compositions that comprise an effective dose of an l0 aqueous extract of red vine leaves and a diuretic as pharmacological active substances and their efficacies are potentiated for preventing and relaxing mild-to-moderate chronic venous insufficiency of the legs.
15 Objectiye of the t~resetat invehtioiZ
A primary objective of this invention provides more effective internal compositions for preventing and alleviating the discomfort associated with mild-to-moderate chronic venous insufficiency of the legs.
2o A further objective of this invention provides more effective internal compositions including herb components and a diuretic. The herb components were manufactured pursuant to a controlled process that preserves the herbal effectiveness of the ingredients for preventing and/or alleviating the discomfort associated with mild-to-moderate chronic venous insufficiency of the legs.
Another objective of this invention provides more effective internal compositions including herb components and a diuretic with minimum or no adverse event for safety of internal consumption that prevent andlor alleviate the discomfort associated with mild-to-moderate chronic venous insufficiency of the legs.
The other objective of this invention provides more effective internal pharmaceutical compositions and foods for preventing andlor alleviating the discomfort associated with mild-to-moderate chronic venous insufficiency of the legs.
DETAILLED DESCRIPTION OF THE TNVENTION
This invention relates to internal compositions for preventing or alleviating the discomfort associated with mild-to-moderate chronic venous insufficiency of the legs including an effective dose of an aqueous extract of red vine leaves and a diuretic.
The internal composition of this invention consists of herbal ingredients derived from an aqueous extraction (Extractu~rz vitis vizziferae a folium spissu~rz et siccunz) of red vine leaves (folza vitis virziferae) and a diuretic.
The primary active ingredient of the internal composition is the aqueous extract of red vine leaves (fodiae vitis vifziferae L.).
The term "aqueous extract of red vine leaves" in this invention means the aqueous or solid aqueous extract of red vine leaves manufactured pursuant to a controlled process that preserves the herbal effectiveness of the ingredients. The term "dried extract of red vine 2o leaves" in this invention means dried pure extract of the above aqueous extract of red vine leaves. The term "red vine leaves extract" in this invention means solid extracts added with silicon dioxide in the range of 1 to 10 (wt/wt)% (described as %) and glucose syrup (as dried material) in the range of 5 to 25 % to the above dried extract of red vine leaves (solid pure extracts) in the range of 70 to 90 %.
Red vine leaves as starting material for the aqueous extract of red vine leaves in this invention is also known as "dyer" which are leaves of vitis viraifera LINNE
with blackish-blue pericarp and a red pulp. Concentration of each polyphenol compound in red vine leaves and its composition are affected by various ecophysiological factors around. It is 3o preferred that dried leaves of red vine containing at least 4 % of total polyphenols and 0.2 % of anthocyans are used as starting material in this invention. Red vine leaves characterized like those are harvested at a point of time where the content of flavonoids has reached an optimum i.e. around the harvesting time of the grapes. Moreover, less than 15 cm length and less than 12 cm width of red vine leaves are preferable. The leaves are carefully dried and crushed. For extraction the leaves are cut to pieces of preferably 5 to 10 mm. To achieve a high content of flavonoids the extraction is done using purified water at elevated temperature, preferably at a temperature in the range of 60 to 80 °C, over a time of at least 6 up to 10 hours. The preferred method is that of an exhaustive percolation.
The so-called fluid extract obtained in the process of the extraction may be directly used in the preparation of liquid dosage forms. In order to get a more concentrated extract, at least a part of the solvent is removed by use of a suitable evaporator preferably.
The thick extract is sterilized under heated-compressed condition, preferably at a temperature from 120 to 150°C for 1 up to 30 seconds, more preferably at a temperature from 140 to 145°C for 2 up to 5 seconds. The thick extract, obtained in this step may again be directly used in the manufacturing of liquid dosage forms.
For the preparation of solid dosage forms the thick extract is dried, for instance by use of a vacuum drying oven or a vacuum drying conveyer. Carnets or excipients may be added during drying to facilitate further processing of the extract.
The ratio of carriers or excipients in the range of 10 to 30 % and dried extract of red vine leaves (as pure extract) in the range of 70 to 90 % in red vine leaves extract is preferable.
Such carriers or excipients exemplify one or more than 2 kinds among silicon dioxide, maltodextrine, glucose syrup, cellulose and others. Silicon dioxide and glucose syrup are preferably used in this invention. The ratio of silicon dioxide in the range of 1 to 10 %, glucose syrup (as dried) in the range of 5 to 25 % and dried extract of red vine leaves (as pure extract) in the range of 70 to 90 % in red vine leaves extract is preferable. The ratio of silicon dioxide 2-5 %, glucose syrup (as dried) 10-20 % and dried extract of red vine leaves (as pure extract) 75-S5 % in red vine leaves extract is more preferable.
The aqueous extract of red vine leaves used in this invention by pure extract conversion of 3o an aqueous extract of red vine leaves contains total flavonoids (quercetin-3-O-beta-D-glucuronide) preferably in the range of 0.625 to 25 %, more preferably in the range of 1.25 to 12.5 %, specially in the range of 2.5 to 10 %. This total fiavonoid (quercetin-3-O-beta-D-glucuronide) content in red vine leaves extract (for example, a case in which dried extract of red vine leaves (as pure extract) 80 %) is preferable from 0.5 to 20 %, more preferable from 1 to 10 %, special from 2 to 8 %.
To prevent and/or alleviate the discomfort of mild-to-moderate chronic venous insufficiency of the legs, the daily dosage of the aqueous extract of red vine leaves for an adult in equivalent quantity of dried extract of red vine leaves (pure extract) is usually from 64 to 800mg, preferably from 240 to 640 mg, more preferably from 280 to 600 mg and further more preferably 360 mg. The daily dosage of the aqueous extract of red vine leaves for an adult in equivalent quantity of red vine leaves extract is usually from 80 to 1000mg, preferably from 300 to 800 mg, more preferably 350 to 750 mg and further more preferably 450 mg.
The compositions according to this invention include diuretics as second active ingredients in addition to above aqueous extract of red vine leaves.
Diuretics used in this invention are not limited and determined if the agents contain diuretic action, however, for safety of this agent with minimum or no adverse event, diuretics with mild effects used in non-prescription drug and health food field for many years are preferable. In addition, types and dosage of diuretics change depending on whether this internal composition is pharmaceutical products or not.
Examples of such diuretics are aminophylline, caffeine, herb and crude drug having diuretics action, and diuretically efficient minerals.
Further in detail, caffeine group includes "caffeine and sodium benzoate", anhydrous caffeine, and caffeine etc.
In addition, examples of such crude drug and herb having diuretic action are poria sclerotium (Poria), akebia stem (Akebiae caulis), akebia fruit (Akebiae fructus), astragalus root (Astragals radix), alisma rhizome (Alismatis rhizorna), jujube (Zizyphi fructus), houttuynia herb (Houttuyniae herbs), plantago seed (Ptarvtaginis semen), plantago herb (Plantaginis lzerba), horsetail herb (Equiseti l2erba), gardenia fruit (Gardenias fructus), nettle leaf (Urticae folium), nettle herb (Urticae lzerba), hibiscus rosell (Hibiscus sabdariffa), anemarrhena rhizome (Ar2emarrhenae rhizoma), motherwort herb (Leonuri herbs), areca husk (Arecae pericarpium), abutilon seed (Abutili semen), campsis flower(Canzpsitis flos), bearberry leaf (Uvae ursi folium), atractylodes lances rhizome (Atractylodis Lanceae rlzizoma), Rice Bean (Plzaseoli semen), nuphar rhizome (Nuplzaris rhizonza), elder (Sambucus sieboldiarza blume ex graebn), inula root (Irzulae radix), rose fruit (Rosae fructus), sinomenium stem (Sinorneni caulis et rlzizorna), hedysarum (Hedysarum polybotrys), magnolia bark (Magnolias cortex), job's-tears seed (Coicis lacryrncc jobii semen), parslane herb (Portulacae herbs), reed rhizome (Plzragrrzitis rhizoma), polyporus (Polyporus umbellatus fries), inula flower (Irzulae f los), pharbitis seed (Pharbitidis serrzen), pumice (Purrzex), honeysuckle stem (Lonicerae caulis), pepperweed seed (Lepidii semen), common scouring rush herb (Equiseti herbs), physalis rhizome and root (Physalitis rlzizorrza et radix), kusnezoff monkshood root (Aconiti kusrzezoffii radix), Chinese lobelia herb (Lobeli.ae Chinensis herbs), beautiful sweetgum fruit (Liquidarrzbaris fructus), aconite(prepared) (Acorziti carmichaeli praeparata rad), dwarf lilyturf tuber (Oplziopogonis tuber), twotoothed achyranthes root (Aclzyrarztlzi.s radix), Chinese waxgourd seed (Benincasae semen), white mulberry root-bark (Mori cortex), loquat leaf (Eriobotryae folium), pucture vine caltrop fruit (Tribuli fructus), natural water-content sodium sulfate (Natrium sulficriczzm), elsholtzia herb (Elsholtziae lzerba), senega (Senegae radix), atractylodes rhizome (Atractylodis rhizorna), lilac pink herb (l~iantlzi herbs), forsythia fruit (Forsythias fructus), lalang grass rhizome (Irnperatae rlzizorna), prunellae spica (Prunellae spica), cubeb pepper (Cubebae fructus), corn silk (Maydis stigmata), lightyellow sophora root (Sophorae radix), albizzia bark (Albizziae cortex), belvedere fruit (Kochiae fructus), Chinese iris seed (Iridis semen), evodia fruit (Evodiae fr uctus), largeleaf gentian root (Gerztianae macroplzyllae radix), papermulberry fruit (Broussonetiae fructus), ramie root (Boehrneriae radix), rush (Junci medulla), photinia leaf (Photirziae foliurn), motherwort fruit (LeorZUri fructus), dandelion (Taraxaci herbs), sea-ear shell (Haliotidis corzcha), earthworm (Lurnbricus), Japanese raisin tree seed (Hoveniae semen), pyrrosia herb (Pyrrosiae herbs), vaccinium (Vitis-idaea), eupatorium herb (Eupatorii herbs), cattail pollen (Typhae pollen), hydrangea (Hydrangea macrophylla), Hyssop (Hyssopus officirzalis), wild oat (Avena sativa), parsely (Petroselinum crispuna), yarrow (Achillea millefolium), alfalfa (Medicago sativa), garden thyme (Thymus vulgaris), marsh mallow (Althaea officinalis), guarana (Paullinia cupana), cranberry (Vacciraiunz oxycocos), juniper (Jurziperus conzmunis), saw palmetto (Serenoa repens), dandelion (Taraxacunz off cinale), mate (Ilex paraguayensis), common mallow (Malva sylvestris), linden (Tilia europaea), rose hip (Rosa canina), valerian (Valeriana officinalis), angelica (Angelica archangelica), orange peel (Citrus sinennsis), citrus unshiu peel (Aurantii nobilis pericarpiunz), celery seed (Apiunz graveolens), Tarragon (Artemisia dracunculus), chicory (Cichorium intybus), dill seed (Anetlzutn graveolens), parsley (Pertroselinunz crispm), meadowsweet (Filipendula ulmaria), linden wood (Tilia cordata), linden flower(Tilia platyplzyllos), linden (Tilia europaea), lemon peel(Citrus llimora), Gurmar (Gymnema sylvestre), fennel (Foeniculunz vulga~-e), sweetleaf (Stevia rebaudiana bertorzi), chicory (Cichoriunz ifitybus), hops (Hunzulus lupulus), mustard (Sinapis alba), achiote (Bixa orellana), yerba mate (Ilex paraguayeyzsis), mutamba (Guazonza ulmifolia lam.), mullaca (Physalis angulata), perilla (Perilla f-utescens), eucommia (Eucomnziae cortex), Cha de Burge (Cordia salicifolia), Pearl barley (Coicis fructus), Goldenrod herb (Solidago, Vif gaureae herba), Restharrow root (Orzonis spinosa radix) and Java tea leaves : cats whiskers (Orthosiphon aristatus) etc.
In addition, these crude drug and herb having diuretic action can be dried powder, extract, and fluidextract etc.
Minerals having diuretic efficacy are any sources of magnesium and potassium.
Minerals used in this invention are preferably water soluble synthetic compounds such as chemical synthetic, enzyme synthetic and also natural products or natural products separated and purified. There is no limit for mineral form used in this invention. For example, the forms include mineral, salt, oxide, protein complex, complex of protein decomposed product, polysaccharide complex, complex of polysaccharide decomposed product, modified starch complex, cyclodextrin complex or metalloenzyme including minerals such as superoxide dismutase, glutathione peroxidase, acid phosphatase, metal activating enzyme including phosphoglucomutase, enzyme and coenzyme including metal except for active centers.
_g_ Exemplifying preferred examples of minerals fox magnesium group include magnesium carbonate, magnesium sulfate, magnesium citrate, magnesium lactate, magnesium chloride, magnesium oxide, magnesium aluminum silicate, magnesium aluminometasilicate, magnesium hydroxide aluminum, magnesium L-aspartate and magnesium L-glutamate.
Magnesium stearate is water insoluble and thus cannot become a source of a mineral.
Therefore, the term "diuretically effective mineral" does not include water insoluble magnesium salts such magnesium stearate.
Potassium group includes potassium chloride, potassium sulfate, potassium carbonate, potassium dihydrogen citrate, tripotassium citrate, potassium gluconate, potassium acetate, tripotassium phosphate, dipotassium hydrogen phosphate, potassium dihydrogen phosphate, potassium hydroxide, aluminum potassium sulfate, potassium L-aspartate, and monopotassium L-glutamate.
Diuretics such as those aminophylline, caffeine, crude drug and herb having diuretic action and minerals etc. can be mixed with one or more than two kinds.
2o Combination amount of diuretics used in this invention components changes depend on types of diuretics and categorization as pharmaceutical products or foods, but a daily dose for an adult is between 1 to 18000 mg.
Specifically, daily combination amount of aminophylline is usually between 1 to 400 mg for an adult, preferably between 5 to 350 mg, more preferably between 10 to 300 mg.
Daily combination amount of caffeine and anhydrous caffeine is usually between ~ to 900 mg for an adult, preferably between 5 to 700 mg, more preferably between 10 to 500 mg and daily combination amount of "caffeine and sodium benzoate" is usually between 2 to 1800 mg for an adult, preferably between 10 to 1200 mg, more preferably between 10 to 600 mg.
_g_ 'Daily combination amount of crude drug and herb having diuretic action is usually between 2 to 18000 mg as crude drug substance for an adult, preferably between 4 to 15000 mg, more preferably between 6 to 12000 mg.
Combination amount of mineral is less than 700 mg as magnesium, preferably 1 to 600 mg, more preferably 3 to 500 mg. Potassium is between less than 4000 mg as potassium, preferably 1 to 3000 mg, more preferably 2 to 2000 mg.
The compositions according to this invention may be administered paxentherally, preferably orally in divided doses, most preferably given once a day in the morning, to especially before breakfast. Dose adjustment of the active ingredients may reflect age, body weight, and manifesting symptoms. In addition to active ingredients mentioned above, the internal compositions in this invention may also include other active ingredients.
15 The oral dosage form described in this invention can be used in various types of oral forms as tablets, granules, fine granules, powders, capsules, caplets, soft capsules, pills, oral solutions, syrups, dry syrups, chewable tablets, troches, effervescent tablets, drops, suspension, oral fast-dispersing tablets, etc. Any of these formulations may be prepa~.red using regular methods, and, in addition to the aforementioned components, any excipients 2o in common use may be used upon preparation of these formulations, if necessary. In addition, preparations formed into microparticles such as microcapsules, nanocapsules, microspheres, nanospheres, and included in the aforementioned formulations.
For example, the active ingredients, i.e. an aqueous extract of red vine leaves and diuretics, can be various types of drug forms as separate granules, mufti-layer granules, mufti-layer 25 tablets or dry coated tablets, tablets of separated granules, microcapsules, etc. Coating preparations such as sugarcoated tablets, film coating tablets, coating granule, can be used as well as chewable tablets, oral fast dispersing tablets, matrix tablets, matrix granules, effervescent tablets, dusting powder, solid solutions, etc. These methods can also be combined. Moreover, the properties of the inventive internal composition such as stability, 3o release, continuance, disintegration, distinglation, dissolution, concealment of taste, improvement in usage etc. can be regulated by the addition of additives known in the art.
These oral dosage form described in this invention may be prepared using regular methods by adding generally available pharmaceutical additives and food additives such as excipients, binders, disintegrators, lubricants, coating agents, sugar coating agents, plasticizers, antifoaming agents, polish, foaming agents, antistatic agents, desiccant, surfactant, solubilizer, buffer agents, resolvents, solubilizing agents, solvents, diluents, stabilizers, emulsifying agents, suspension, suspending agents, dispersing agents, isotonizing agents, adsorbents, reducing agents, antioxidant, wetting agents, wet modifier, filler, extender, adhesives, viscous agent, softeners, pH modifiers, antiseptics, 1o preservatives, sweetening agents, corrigent, refrigerative agents, flavoring agents, perfume, fragrance, and coloring matters to the active compounds. Examples of such additives are described in Japanese Pharmaceutical Excipients Directory 2000 (edited by Japan Pharmaceutical Excipients Council, issued by Yakuji Nippo, Ltd.) and The Japan's Specifications and Standards for Food Additives (issued by Japan Food Additives Association).
The compositions according to this invention can be provided as pharmaceutical products or foods. The compositions described in this invention are explained by the following practical examples. However, the scope of this invention is not limited to these practical examples.
Examples Example 1 Capsules The following ingredients were prepared as granules through regular methods, and capsule-filled to give an amount of 280 mg per one capsules.
Red vine leaves extract 450 g Alisma rhizome extract 50 g (Alisma rhizome 500g) Corn starch 30 g Light anhydrous silicic acid 6 g Talc 18 g Magnesium stearate 6 g (Red vine leaves extract = dried aqueous extract of red vine leaves (pure extract): silicon dioxide: glucose syrup (as dried glucose)) = 80: 3: 17 wtiwt%) Example 2 Granules The following ingredients were prepared as granules through a regular method to prepare mixed particles, and packed to nt of 2000 mg per one pack for give an amou granules.
Red vine leaves extract 22.5 g Poria sclerotium extract 8 g (Poria sclerotium 240g) Polyporus extract 25 g (Polyporus 250g) Sinomenium stem extract 40 g (Sinomenium stem 500g) Aminophylline 10 g Calcium carboxymethylcellulose 80 g Mannitol 410 g Corn starch 182 g Tartaric acid 8 g Aspartame 8 g Acesulfame potassium 3 g Fragrant materials 1 g (Red vine leaves extract = dried aqueous extract of red vine leaves (pure extract): silicon dioxide: glucose syrup (as dried glucose)) = 80: 3: 17 wt/wt%) to Example 3 Powder The following ingredients were homogeneously mixed. The resulted mixed particles were divided into portions of 1000 mg to prepare powder compositions.
Red vine leaves extract 450 g Akebia stem extract 100 g (Akebia stem 2500g) Astragalus root extract SO g (Astragalus root SOOg) Jujube extract 100 g (Jujube 250g) Pyridoxine hydrochloride SO g Corn starch 124 g Lactose 108 g Light anhydrous silicic acid 10 g Magnesium stearate 8 g (Red vine leaves extract = dried aqueous extract of red vine leaves (pure extract): silicon dioxide: glucose syrup (as dried glucose)) = 80: 3: 17 wt/wt%) Example 4 Tablet The following ingredients were homogeneously mixed. The resulted mixed particles were to compressed with a mold to prepare tablets at 300 mg each.
Red vine leaves extract 450 g Anhydrous caffeine 10 g Potassium L-aspartate 20 g Pyridoxine hydrochloride 10 g Lactose 100 g Microcrystalline cellulose 296 g Light anhydrous silicic acid 7 g Magnesium stearate S g Talc 2 g (Red vine leaves extract = dried aqueous extract of red vine leaves (pure extract): silicon dioxide: glucose syrup (as dried glucose)) _ ~0: 3: 17 wt/wt%)
Chronic venous insufficiency (CVI) is a functional disorder caused by persistent inadequacy of the venous return and is characterized clinically by oedema, shin changes and subjective complaints such as tired, heavy legs, pain or tingling sensations, which are typically amplified by standing upright and by high ambient temperatures. This dysfunction may be a source of major distress with a significant negative impact on the patient's overall well-being and quality of life.
Early stages (grade I) are characterized by coronal phlebectasia parapiantaris, subfasciai congestion and oedema; grade II CVI is associated with low-grade skin changes, eczema and lipodermatosclerosis. If untreated, grades I and II often progress to an advanced stage characterized by recurrent venous leg ulcers (grade III). The stress caused by the symptoms, even when relatively mild initially, and the risk of later complications call for appropriate supportive and preventive measures to be initiated in the early stages of CVI.
Although some patients, even at early stages, might require surgery (sclerotherapy and variceal surgery), the use of compression stockings with or without additional physiotherapy is the most common treatment approach. The effect of compression is merely mechanical, i.e. this approach does not affect or correct the related biological dysfunction (capillary fragility in particular). Furthermore, the treatment with compression l0 stockings often lacks compliance because of cosmetic concerns and the overall inconvenience of the c~mpressive stockings, in the summer in particular.
Therefore there is an urgent need for alternative approaches that are effective, well-tolerated and more convenient.
This extract of red vine leaves contains flavon (ol) -glycosides, -glucuronides and flavonoids, with quercetin-3-O-beta-D-glucuronide and isoquercitrin (quercetin-3-O-beta-glucoside) as its main active ingredients. The range of their pharmacological actions has not yet been fully elucidated, but in-vitro studies indicate that they have antioxidant and anti-inflammatory properties and that they inhibit platelet aggregation and hyaluronidase and reduce oedema, possibly by reducing capillary permeability. Preclinical in-vivo experiments~demonstrated anti-inflammatory and capillary wall thickening effects.
Dietary supplements including an aqueous extract of red vine leaves are disclosed to prevent and reduce the discomfort relating to mild-to-moderate chronic venous insufficiency of the legs in WO 01128363. However, there are no hints to compositions comprising an aqueous extract of red vine leaves and other active ingredients such as diuretics given by WO 01/28363.
SHORT DESCRIPTION OF THE INVENTION
3o Surprisingly, potentiation of anti-inflammatory action and inhibitory action on oedema, indices of pharmacological activities of an aqueous extract of red vine leaves, is found by _2_ combination of a diuretic with an aqueous extract of red vine leaves comparing the action itself. Moreover, composing nuld diuretics resulted in safe compositions whose efficacy is potentiated for preventing and alleviating discomfort relating to mild-to-moderate chronic venous insufficiency of the legs with minimum or no adverse reactions. The new compositions comprising a diuretic and an aqueous extract of red vine leaves potentiate the efficacy of prevention or relaxation for mild-to-moderate chronic venous insufficiency of the legs.
Therefore, this invention relates to new compositions that comprise an effective dose of an l0 aqueous extract of red vine leaves and a diuretic as pharmacological active substances and their efficacies are potentiated for preventing and relaxing mild-to-moderate chronic venous insufficiency of the legs.
15 Objectiye of the t~resetat invehtioiZ
A primary objective of this invention provides more effective internal compositions for preventing and alleviating the discomfort associated with mild-to-moderate chronic venous insufficiency of the legs.
2o A further objective of this invention provides more effective internal compositions including herb components and a diuretic. The herb components were manufactured pursuant to a controlled process that preserves the herbal effectiveness of the ingredients for preventing and/or alleviating the discomfort associated with mild-to-moderate chronic venous insufficiency of the legs.
Another objective of this invention provides more effective internal compositions including herb components and a diuretic with minimum or no adverse event for safety of internal consumption that prevent andlor alleviate the discomfort associated with mild-to-moderate chronic venous insufficiency of the legs.
The other objective of this invention provides more effective internal pharmaceutical compositions and foods for preventing andlor alleviating the discomfort associated with mild-to-moderate chronic venous insufficiency of the legs.
DETAILLED DESCRIPTION OF THE TNVENTION
This invention relates to internal compositions for preventing or alleviating the discomfort associated with mild-to-moderate chronic venous insufficiency of the legs including an effective dose of an aqueous extract of red vine leaves and a diuretic.
The internal composition of this invention consists of herbal ingredients derived from an aqueous extraction (Extractu~rz vitis vizziferae a folium spissu~rz et siccunz) of red vine leaves (folza vitis virziferae) and a diuretic.
The primary active ingredient of the internal composition is the aqueous extract of red vine leaves (fodiae vitis vifziferae L.).
The term "aqueous extract of red vine leaves" in this invention means the aqueous or solid aqueous extract of red vine leaves manufactured pursuant to a controlled process that preserves the herbal effectiveness of the ingredients. The term "dried extract of red vine 2o leaves" in this invention means dried pure extract of the above aqueous extract of red vine leaves. The term "red vine leaves extract" in this invention means solid extracts added with silicon dioxide in the range of 1 to 10 (wt/wt)% (described as %) and glucose syrup (as dried material) in the range of 5 to 25 % to the above dried extract of red vine leaves (solid pure extracts) in the range of 70 to 90 %.
Red vine leaves as starting material for the aqueous extract of red vine leaves in this invention is also known as "dyer" which are leaves of vitis viraifera LINNE
with blackish-blue pericarp and a red pulp. Concentration of each polyphenol compound in red vine leaves and its composition are affected by various ecophysiological factors around. It is 3o preferred that dried leaves of red vine containing at least 4 % of total polyphenols and 0.2 % of anthocyans are used as starting material in this invention. Red vine leaves characterized like those are harvested at a point of time where the content of flavonoids has reached an optimum i.e. around the harvesting time of the grapes. Moreover, less than 15 cm length and less than 12 cm width of red vine leaves are preferable. The leaves are carefully dried and crushed. For extraction the leaves are cut to pieces of preferably 5 to 10 mm. To achieve a high content of flavonoids the extraction is done using purified water at elevated temperature, preferably at a temperature in the range of 60 to 80 °C, over a time of at least 6 up to 10 hours. The preferred method is that of an exhaustive percolation.
The so-called fluid extract obtained in the process of the extraction may be directly used in the preparation of liquid dosage forms. In order to get a more concentrated extract, at least a part of the solvent is removed by use of a suitable evaporator preferably.
The thick extract is sterilized under heated-compressed condition, preferably at a temperature from 120 to 150°C for 1 up to 30 seconds, more preferably at a temperature from 140 to 145°C for 2 up to 5 seconds. The thick extract, obtained in this step may again be directly used in the manufacturing of liquid dosage forms.
For the preparation of solid dosage forms the thick extract is dried, for instance by use of a vacuum drying oven or a vacuum drying conveyer. Carnets or excipients may be added during drying to facilitate further processing of the extract.
The ratio of carriers or excipients in the range of 10 to 30 % and dried extract of red vine leaves (as pure extract) in the range of 70 to 90 % in red vine leaves extract is preferable.
Such carriers or excipients exemplify one or more than 2 kinds among silicon dioxide, maltodextrine, glucose syrup, cellulose and others. Silicon dioxide and glucose syrup are preferably used in this invention. The ratio of silicon dioxide in the range of 1 to 10 %, glucose syrup (as dried) in the range of 5 to 25 % and dried extract of red vine leaves (as pure extract) in the range of 70 to 90 % in red vine leaves extract is preferable. The ratio of silicon dioxide 2-5 %, glucose syrup (as dried) 10-20 % and dried extract of red vine leaves (as pure extract) 75-S5 % in red vine leaves extract is more preferable.
The aqueous extract of red vine leaves used in this invention by pure extract conversion of 3o an aqueous extract of red vine leaves contains total flavonoids (quercetin-3-O-beta-D-glucuronide) preferably in the range of 0.625 to 25 %, more preferably in the range of 1.25 to 12.5 %, specially in the range of 2.5 to 10 %. This total fiavonoid (quercetin-3-O-beta-D-glucuronide) content in red vine leaves extract (for example, a case in which dried extract of red vine leaves (as pure extract) 80 %) is preferable from 0.5 to 20 %, more preferable from 1 to 10 %, special from 2 to 8 %.
To prevent and/or alleviate the discomfort of mild-to-moderate chronic venous insufficiency of the legs, the daily dosage of the aqueous extract of red vine leaves for an adult in equivalent quantity of dried extract of red vine leaves (pure extract) is usually from 64 to 800mg, preferably from 240 to 640 mg, more preferably from 280 to 600 mg and further more preferably 360 mg. The daily dosage of the aqueous extract of red vine leaves for an adult in equivalent quantity of red vine leaves extract is usually from 80 to 1000mg, preferably from 300 to 800 mg, more preferably 350 to 750 mg and further more preferably 450 mg.
The compositions according to this invention include diuretics as second active ingredients in addition to above aqueous extract of red vine leaves.
Diuretics used in this invention are not limited and determined if the agents contain diuretic action, however, for safety of this agent with minimum or no adverse event, diuretics with mild effects used in non-prescription drug and health food field for many years are preferable. In addition, types and dosage of diuretics change depending on whether this internal composition is pharmaceutical products or not.
Examples of such diuretics are aminophylline, caffeine, herb and crude drug having diuretics action, and diuretically efficient minerals.
Further in detail, caffeine group includes "caffeine and sodium benzoate", anhydrous caffeine, and caffeine etc.
In addition, examples of such crude drug and herb having diuretic action are poria sclerotium (Poria), akebia stem (Akebiae caulis), akebia fruit (Akebiae fructus), astragalus root (Astragals radix), alisma rhizome (Alismatis rhizorna), jujube (Zizyphi fructus), houttuynia herb (Houttuyniae herbs), plantago seed (Ptarvtaginis semen), plantago herb (Plantaginis lzerba), horsetail herb (Equiseti l2erba), gardenia fruit (Gardenias fructus), nettle leaf (Urticae folium), nettle herb (Urticae lzerba), hibiscus rosell (Hibiscus sabdariffa), anemarrhena rhizome (Ar2emarrhenae rhizoma), motherwort herb (Leonuri herbs), areca husk (Arecae pericarpium), abutilon seed (Abutili semen), campsis flower(Canzpsitis flos), bearberry leaf (Uvae ursi folium), atractylodes lances rhizome (Atractylodis Lanceae rlzizoma), Rice Bean (Plzaseoli semen), nuphar rhizome (Nuplzaris rhizonza), elder (Sambucus sieboldiarza blume ex graebn), inula root (Irzulae radix), rose fruit (Rosae fructus), sinomenium stem (Sinorneni caulis et rlzizorna), hedysarum (Hedysarum polybotrys), magnolia bark (Magnolias cortex), job's-tears seed (Coicis lacryrncc jobii semen), parslane herb (Portulacae herbs), reed rhizome (Plzragrrzitis rhizoma), polyporus (Polyporus umbellatus fries), inula flower (Irzulae f los), pharbitis seed (Pharbitidis serrzen), pumice (Purrzex), honeysuckle stem (Lonicerae caulis), pepperweed seed (Lepidii semen), common scouring rush herb (Equiseti herbs), physalis rhizome and root (Physalitis rlzizorrza et radix), kusnezoff monkshood root (Aconiti kusrzezoffii radix), Chinese lobelia herb (Lobeli.ae Chinensis herbs), beautiful sweetgum fruit (Liquidarrzbaris fructus), aconite(prepared) (Acorziti carmichaeli praeparata rad), dwarf lilyturf tuber (Oplziopogonis tuber), twotoothed achyranthes root (Aclzyrarztlzi.s radix), Chinese waxgourd seed (Benincasae semen), white mulberry root-bark (Mori cortex), loquat leaf (Eriobotryae folium), pucture vine caltrop fruit (Tribuli fructus), natural water-content sodium sulfate (Natrium sulficriczzm), elsholtzia herb (Elsholtziae lzerba), senega (Senegae radix), atractylodes rhizome (Atractylodis rhizorna), lilac pink herb (l~iantlzi herbs), forsythia fruit (Forsythias fructus), lalang grass rhizome (Irnperatae rlzizorna), prunellae spica (Prunellae spica), cubeb pepper (Cubebae fructus), corn silk (Maydis stigmata), lightyellow sophora root (Sophorae radix), albizzia bark (Albizziae cortex), belvedere fruit (Kochiae fructus), Chinese iris seed (Iridis semen), evodia fruit (Evodiae fr uctus), largeleaf gentian root (Gerztianae macroplzyllae radix), papermulberry fruit (Broussonetiae fructus), ramie root (Boehrneriae radix), rush (Junci medulla), photinia leaf (Photirziae foliurn), motherwort fruit (LeorZUri fructus), dandelion (Taraxaci herbs), sea-ear shell (Haliotidis corzcha), earthworm (Lurnbricus), Japanese raisin tree seed (Hoveniae semen), pyrrosia herb (Pyrrosiae herbs), vaccinium (Vitis-idaea), eupatorium herb (Eupatorii herbs), cattail pollen (Typhae pollen), hydrangea (Hydrangea macrophylla), Hyssop (Hyssopus officirzalis), wild oat (Avena sativa), parsely (Petroselinum crispuna), yarrow (Achillea millefolium), alfalfa (Medicago sativa), garden thyme (Thymus vulgaris), marsh mallow (Althaea officinalis), guarana (Paullinia cupana), cranberry (Vacciraiunz oxycocos), juniper (Jurziperus conzmunis), saw palmetto (Serenoa repens), dandelion (Taraxacunz off cinale), mate (Ilex paraguayensis), common mallow (Malva sylvestris), linden (Tilia europaea), rose hip (Rosa canina), valerian (Valeriana officinalis), angelica (Angelica archangelica), orange peel (Citrus sinennsis), citrus unshiu peel (Aurantii nobilis pericarpiunz), celery seed (Apiunz graveolens), Tarragon (Artemisia dracunculus), chicory (Cichorium intybus), dill seed (Anetlzutn graveolens), parsley (Pertroselinunz crispm), meadowsweet (Filipendula ulmaria), linden wood (Tilia cordata), linden flower(Tilia platyplzyllos), linden (Tilia europaea), lemon peel(Citrus llimora), Gurmar (Gymnema sylvestre), fennel (Foeniculunz vulga~-e), sweetleaf (Stevia rebaudiana bertorzi), chicory (Cichoriunz ifitybus), hops (Hunzulus lupulus), mustard (Sinapis alba), achiote (Bixa orellana), yerba mate (Ilex paraguayeyzsis), mutamba (Guazonza ulmifolia lam.), mullaca (Physalis angulata), perilla (Perilla f-utescens), eucommia (Eucomnziae cortex), Cha de Burge (Cordia salicifolia), Pearl barley (Coicis fructus), Goldenrod herb (Solidago, Vif gaureae herba), Restharrow root (Orzonis spinosa radix) and Java tea leaves : cats whiskers (Orthosiphon aristatus) etc.
In addition, these crude drug and herb having diuretic action can be dried powder, extract, and fluidextract etc.
Minerals having diuretic efficacy are any sources of magnesium and potassium.
Minerals used in this invention are preferably water soluble synthetic compounds such as chemical synthetic, enzyme synthetic and also natural products or natural products separated and purified. There is no limit for mineral form used in this invention. For example, the forms include mineral, salt, oxide, protein complex, complex of protein decomposed product, polysaccharide complex, complex of polysaccharide decomposed product, modified starch complex, cyclodextrin complex or metalloenzyme including minerals such as superoxide dismutase, glutathione peroxidase, acid phosphatase, metal activating enzyme including phosphoglucomutase, enzyme and coenzyme including metal except for active centers.
_g_ Exemplifying preferred examples of minerals fox magnesium group include magnesium carbonate, magnesium sulfate, magnesium citrate, magnesium lactate, magnesium chloride, magnesium oxide, magnesium aluminum silicate, magnesium aluminometasilicate, magnesium hydroxide aluminum, magnesium L-aspartate and magnesium L-glutamate.
Magnesium stearate is water insoluble and thus cannot become a source of a mineral.
Therefore, the term "diuretically effective mineral" does not include water insoluble magnesium salts such magnesium stearate.
Potassium group includes potassium chloride, potassium sulfate, potassium carbonate, potassium dihydrogen citrate, tripotassium citrate, potassium gluconate, potassium acetate, tripotassium phosphate, dipotassium hydrogen phosphate, potassium dihydrogen phosphate, potassium hydroxide, aluminum potassium sulfate, potassium L-aspartate, and monopotassium L-glutamate.
Diuretics such as those aminophylline, caffeine, crude drug and herb having diuretic action and minerals etc. can be mixed with one or more than two kinds.
2o Combination amount of diuretics used in this invention components changes depend on types of diuretics and categorization as pharmaceutical products or foods, but a daily dose for an adult is between 1 to 18000 mg.
Specifically, daily combination amount of aminophylline is usually between 1 to 400 mg for an adult, preferably between 5 to 350 mg, more preferably between 10 to 300 mg.
Daily combination amount of caffeine and anhydrous caffeine is usually between ~ to 900 mg for an adult, preferably between 5 to 700 mg, more preferably between 10 to 500 mg and daily combination amount of "caffeine and sodium benzoate" is usually between 2 to 1800 mg for an adult, preferably between 10 to 1200 mg, more preferably between 10 to 600 mg.
_g_ 'Daily combination amount of crude drug and herb having diuretic action is usually between 2 to 18000 mg as crude drug substance for an adult, preferably between 4 to 15000 mg, more preferably between 6 to 12000 mg.
Combination amount of mineral is less than 700 mg as magnesium, preferably 1 to 600 mg, more preferably 3 to 500 mg. Potassium is between less than 4000 mg as potassium, preferably 1 to 3000 mg, more preferably 2 to 2000 mg.
The compositions according to this invention may be administered paxentherally, preferably orally in divided doses, most preferably given once a day in the morning, to especially before breakfast. Dose adjustment of the active ingredients may reflect age, body weight, and manifesting symptoms. In addition to active ingredients mentioned above, the internal compositions in this invention may also include other active ingredients.
15 The oral dosage form described in this invention can be used in various types of oral forms as tablets, granules, fine granules, powders, capsules, caplets, soft capsules, pills, oral solutions, syrups, dry syrups, chewable tablets, troches, effervescent tablets, drops, suspension, oral fast-dispersing tablets, etc. Any of these formulations may be prepa~.red using regular methods, and, in addition to the aforementioned components, any excipients 2o in common use may be used upon preparation of these formulations, if necessary. In addition, preparations formed into microparticles such as microcapsules, nanocapsules, microspheres, nanospheres, and included in the aforementioned formulations.
For example, the active ingredients, i.e. an aqueous extract of red vine leaves and diuretics, can be various types of drug forms as separate granules, mufti-layer granules, mufti-layer 25 tablets or dry coated tablets, tablets of separated granules, microcapsules, etc. Coating preparations such as sugarcoated tablets, film coating tablets, coating granule, can be used as well as chewable tablets, oral fast dispersing tablets, matrix tablets, matrix granules, effervescent tablets, dusting powder, solid solutions, etc. These methods can also be combined. Moreover, the properties of the inventive internal composition such as stability, 3o release, continuance, disintegration, distinglation, dissolution, concealment of taste, improvement in usage etc. can be regulated by the addition of additives known in the art.
These oral dosage form described in this invention may be prepared using regular methods by adding generally available pharmaceutical additives and food additives such as excipients, binders, disintegrators, lubricants, coating agents, sugar coating agents, plasticizers, antifoaming agents, polish, foaming agents, antistatic agents, desiccant, surfactant, solubilizer, buffer agents, resolvents, solubilizing agents, solvents, diluents, stabilizers, emulsifying agents, suspension, suspending agents, dispersing agents, isotonizing agents, adsorbents, reducing agents, antioxidant, wetting agents, wet modifier, filler, extender, adhesives, viscous agent, softeners, pH modifiers, antiseptics, 1o preservatives, sweetening agents, corrigent, refrigerative agents, flavoring agents, perfume, fragrance, and coloring matters to the active compounds. Examples of such additives are described in Japanese Pharmaceutical Excipients Directory 2000 (edited by Japan Pharmaceutical Excipients Council, issued by Yakuji Nippo, Ltd.) and The Japan's Specifications and Standards for Food Additives (issued by Japan Food Additives Association).
The compositions according to this invention can be provided as pharmaceutical products or foods. The compositions described in this invention are explained by the following practical examples. However, the scope of this invention is not limited to these practical examples.
Examples Example 1 Capsules The following ingredients were prepared as granules through regular methods, and capsule-filled to give an amount of 280 mg per one capsules.
Red vine leaves extract 450 g Alisma rhizome extract 50 g (Alisma rhizome 500g) Corn starch 30 g Light anhydrous silicic acid 6 g Talc 18 g Magnesium stearate 6 g (Red vine leaves extract = dried aqueous extract of red vine leaves (pure extract): silicon dioxide: glucose syrup (as dried glucose)) = 80: 3: 17 wtiwt%) Example 2 Granules The following ingredients were prepared as granules through a regular method to prepare mixed particles, and packed to nt of 2000 mg per one pack for give an amou granules.
Red vine leaves extract 22.5 g Poria sclerotium extract 8 g (Poria sclerotium 240g) Polyporus extract 25 g (Polyporus 250g) Sinomenium stem extract 40 g (Sinomenium stem 500g) Aminophylline 10 g Calcium carboxymethylcellulose 80 g Mannitol 410 g Corn starch 182 g Tartaric acid 8 g Aspartame 8 g Acesulfame potassium 3 g Fragrant materials 1 g (Red vine leaves extract = dried aqueous extract of red vine leaves (pure extract): silicon dioxide: glucose syrup (as dried glucose)) = 80: 3: 17 wt/wt%) to Example 3 Powder The following ingredients were homogeneously mixed. The resulted mixed particles were divided into portions of 1000 mg to prepare powder compositions.
Red vine leaves extract 450 g Akebia stem extract 100 g (Akebia stem 2500g) Astragalus root extract SO g (Astragalus root SOOg) Jujube extract 100 g (Jujube 250g) Pyridoxine hydrochloride SO g Corn starch 124 g Lactose 108 g Light anhydrous silicic acid 10 g Magnesium stearate 8 g (Red vine leaves extract = dried aqueous extract of red vine leaves (pure extract): silicon dioxide: glucose syrup (as dried glucose)) = 80: 3: 17 wt/wt%) Example 4 Tablet The following ingredients were homogeneously mixed. The resulted mixed particles were to compressed with a mold to prepare tablets at 300 mg each.
Red vine leaves extract 450 g Anhydrous caffeine 10 g Potassium L-aspartate 20 g Pyridoxine hydrochloride 10 g Lactose 100 g Microcrystalline cellulose 296 g Light anhydrous silicic acid 7 g Magnesium stearate S g Talc 2 g (Red vine leaves extract = dried aqueous extract of red vine leaves (pure extract): silicon dioxide: glucose syrup (as dried glucose)) _ ~0: 3: 17 wt/wt%)
Claims (12)
1. A composition for the prevention and/or alleviation of mild-to-moderate chronic venous insufficiency (CVI) of the legs comprising an aqueous extract of red vine leaves (1) and a diuretic (2) as pharmacologically active substances.
2. A composition according to claim 1 containing an aqueous extract of red vine leaves (1), which is obtained by extraction from dried red vine leaves containing at least 4 % of total polyphenols and at least 0.2 % of anthocyans using purified water.
3. A composition according to claim 1 or 2, which contains from 50 to 1000 mg, preferably 64 to 800 mg, in particular about 360 mg or 450 mg of dried aqueous extract of red vine leaves (1).
4. A composition according to any one of claims 1 to 3, which contains from 0.625 to 25 % by weight, preferably from 2.5 and 10 % by weight of flavonoids in the dried aqueous extract of red vine leaves (1).
5. A composition according to any one of claims 1 to 4, which contains dried aqueous extract of red vine leaves (1) and an excipient.
6. A composition according to any one of claims 1 to 5, which contains from 70 and 90 % by weight, preferably 75 to 85 % by weight of dried aqueous extract of red vine leaves (1) and from 10 to 30 % by weight, preferably 10 to 20 % by weight of an excipient.
7. A composition according to any one of claims 1 to 6, which contains 2 to 5 % by weight of silicon dioxide and 10 to 20 % by weight of glucose syrup.
8. A composition according to any one of claims 1 to 7, wherein the diuretic (2) is selected from the group consisting of aminophylline, caffeine, vitamin B6, herb and crude drug including diuretics and a diuretically efficient mineral or a mixture thereof.
9. A composition according to any one of claims 1 and 8, which contains 1 to 18,000 mg of one or more diuretics (2).
10. A composition according to any one of claims 1 and 9, wherein the weight ratio between the dried aqueous extract of red vine leaves (1) to diuretic (2) is from 1 to 1,000 to 1,000 to 1.
11. A composition according to any one of claims 1 and 10, which is suitable for parenteral, preferably oral administration.
12. Use of a composition as claimed in any one of claims 1 to 11 for the preparation of a pharmaceutical product or a health food for the prevention and/or alleviation of mild-to-moderate chronic venous insufficiency (CVI) of the legs.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03029900A EP1550451A1 (en) | 2003-12-29 | 2003-12-29 | Composition comprising an aqueous extract of red vine leaves and a diuretic for the treatment of chronic venous insufficiencies |
| EP03029900.2 | 2003-12-29 | ||
| PCT/EP2004/014458 WO2005063270A1 (en) | 2003-12-29 | 2004-12-18 | Composition comprising an aqueous extract of red vine leaves and a diuretic for the treatment of chronic venous insufficiences |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2548357A1 true CA2548357A1 (en) | 2005-07-14 |
Family
ID=34560172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002548357A Abandoned CA2548357A1 (en) | 2003-12-29 | 2004-12-18 | Composition comprising an aqueous extract of red vine leaves and a diuretic for the treatment of chronic venous insufficiences |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20050142236A1 (en) |
| EP (2) | EP1550451A1 (en) |
| JP (1) | JP2007517785A (en) |
| BR (1) | BRPI0418293A (en) |
| CA (1) | CA2548357A1 (en) |
| MX (1) | MXPA06007499A (en) |
| RU (1) | RU2006127295A (en) |
| WO (1) | WO2005063270A1 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001122791A (en) * | 1999-10-20 | 2001-05-08 | Boehringer Ingelheim Internatl Gmbh | Meal enhancer comprising aqueous extract of red vine leaf for alleviation and prophylaxis of chronic venous insufficiency in lower extremity |
| EP1550450A1 (en) * | 2003-12-29 | 2005-07-06 | Boehringer Ingelheim International GmbH | Composition comprising an aqueous extract of red vine leaves and a blood circulating-improving agent for the treatment of chronic venous insufficiencies |
| CA2551787C (en) * | 2004-02-19 | 2014-04-08 | Boehringer Ingelheim International Gmbh | Composition for the treatment of chronic venous insufficiencies comprising an extract of red vine leaves and an anti-inflammatory agent |
| KR101527829B1 (en) | 2007-04-19 | 2015-06-12 | 마리 케이 인코포레이티드 | Magnolia extract containing compositions |
| WO2008152624A2 (en) * | 2007-06-15 | 2008-12-18 | Antaki Center For Herbal Medicine Ltd | Herbal energy-enhancing formulation |
| CA2697954C (en) * | 2007-08-31 | 2019-04-09 | Boehringer Ingelheim International Gmbh | Sprayable composition comprising extract of red vine leaves |
| ITTO20070861A1 (en) * | 2007-11-29 | 2009-05-30 | Vincenzo Cianni | NATURAL FOOD SUPPLEMENT INCLUDING ACTIVE PRINCIPLES OF LEMON FRUIT (CITRUS LIMONUM) AND RED VINE LEAVES (VITIS VINIFERA) |
| JP4778004B2 (en) * | 2008-01-16 | 2011-09-21 | 濱野 吉秀 | Aoba tea and method for producing the same |
| DE102008012908A1 (en) * | 2008-03-06 | 2009-09-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Method for the anti-inflammatory and anti-edematous protection of explanted biological material up to its transplantation in patients |
| RU2563190C2 (en) * | 2012-06-14 | 2015-09-20 | Открытое Акционерное Общество "Татхимфармпрераты" | Medication based on dry extracts of medicinal plants and method of obtaining thereof (versions) |
| JP6321908B2 (en) * | 2013-02-19 | 2018-05-09 | エスエス製薬株式会社 | Oral composition for swelling treatment |
| KR101483990B1 (en) | 2013-04-23 | 2015-01-20 | 한국식품연구원 | Method for Evaluating Samples having Effects of Alleviation, Prevention or Treatment for Pain |
| WO2014175518A1 (en) * | 2013-04-23 | 2014-10-30 | 한국식품연구원 | Composition for relieving, preventing, or treating pain containing mate extract as active ingredient, and method for evaluating pain relief, prevention, or treatment efficacy of sample |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL278161A (en) * | 1961-05-13 | |||
| JPS55111791A (en) * | 1979-02-22 | 1980-08-28 | Japan Synthetic Rubber Co Ltd | Antitumor substance |
| US6210680B1 (en) * | 1999-06-11 | 2001-04-03 | Univera Pharmaceuticals, Inc. | Method for the prevention and treatment of chronic venous insufficiency |
| JP2001122791A (en) * | 1999-10-20 | 2001-05-08 | Boehringer Ingelheim Internatl Gmbh | Meal enhancer comprising aqueous extract of red vine leaf for alleviation and prophylaxis of chronic venous insufficiency in lower extremity |
| EP1278559B1 (en) * | 2000-04-28 | 2008-03-26 | Baylor College Of Medicine | Decellularised vascular prostheses |
| US20020192834A1 (en) * | 2001-03-23 | 2002-12-19 | Sand Bruce J. | Analysis of caffeine |
| JP4836388B2 (en) * | 2002-03-22 | 2011-12-14 | 第一三共株式会社 | Preventive or therapeutic agent for diseases caused by eNOS expression |
| ITGE20020026A1 (en) * | 2002-03-25 | 2003-09-25 | Segre Silvia Perella | COMPOUND TO BE USED IN SCLEROTHERAPY TREATMENT, IN VENOUS INSUFFICIENCY AND IN MICROCIRCULATION ALTERATIONS. |
| US20040146539A1 (en) * | 2003-01-24 | 2004-07-29 | Gupta Shyam K. | Topical Nutraceutical Compositions with Selective Body Slimming and Tone Firming Antiaging Benefits |
-
2003
- 2003-12-29 EP EP03029900A patent/EP1550451A1/en not_active Withdrawn
-
2004
- 2004-12-02 US US11/002,054 patent/US20050142236A1/en not_active Abandoned
- 2004-12-18 EP EP04804059A patent/EP1708729A1/en not_active Withdrawn
- 2004-12-18 MX MXPA06007499A patent/MXPA06007499A/en not_active Application Discontinuation
- 2004-12-18 JP JP2006546018A patent/JP2007517785A/en active Pending
- 2004-12-18 CA CA002548357A patent/CA2548357A1/en not_active Abandoned
- 2004-12-18 BR BRPI0418293-6A patent/BRPI0418293A/en not_active Application Discontinuation
- 2004-12-18 RU RU2006127295/15A patent/RU2006127295A/en not_active Application Discontinuation
- 2004-12-18 WO PCT/EP2004/014458 patent/WO2005063270A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1550451A1 (en) | 2005-07-06 |
| BRPI0418293A (en) | 2007-05-02 |
| RU2006127295A (en) | 2008-02-10 |
| JP2007517785A (en) | 2007-07-05 |
| US20050142236A1 (en) | 2005-06-30 |
| EP1708729A1 (en) | 2006-10-11 |
| WO2005063270A1 (en) | 2005-07-14 |
| MXPA06007499A (en) | 2006-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2551787C (en) | Composition for the treatment of chronic venous insufficiencies comprising an extract of red vine leaves and an anti-inflammatory agent | |
| US7422760B2 (en) | Plant-based medicament for the treatment of Hepatitis C | |
| ZA200604097B (en) | Composition comprising an aqueous extract of red vine leaves and a blood circulation-improving agent for the treatment of chronic venous insufficiences | |
| US20050142236A1 (en) | Composition comprising an aqueous extract of red vine leaves and a diuretic | |
| CA2386215C (en) | Method for treatment of chronic venous insufficiencies using an extract of red vine leaves | |
| US20050142235A1 (en) | Composition comprising an aqueous extract of red vine leaves and an antithrombotic agent | |
| KR101043212B1 (en) | A food for improving brain function | |
| CN114794478B (en) | Composition capable of reducing blood pressure, blood lipid and blood sugar and application | |
| CN107890528B (en) | Traditional Chinese medicine composition for treating hyperuricemia and preparation method thereof | |
| KR102395338B1 (en) | Oral composition for improving systemic symptoms including sensitivity to cold | |
| JP6321908B2 (en) | Oral composition for swelling treatment | |
| AU2006200036B2 (en) | Vitamin composition, methods and applications | |
| KR101665093B1 (en) | Composition for teeth-alveolar bone and functional food containing the same | |
| MXPA06008457A (en) | Composition for the treatment of chronic venous insufficiencies comprising an extract of red vine leaves and an anti-inflammatory agent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |