CA2556183A1 - Bone graft substitute - Google Patents

Bone graft substitute Download PDF

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Publication number
CA2556183A1
CA2556183A1 CA002556183A CA2556183A CA2556183A1 CA 2556183 A1 CA2556183 A1 CA 2556183A1 CA 002556183 A CA002556183 A CA 002556183A CA 2556183 A CA2556183 A CA 2556183A CA 2556183 A1 CA2556183 A1 CA 2556183A1
Authority
CA
Canada
Prior art keywords
bone
restorative
collagen
biocompatible
graft
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002556183A
Other languages
French (fr)
Other versions
CA2556183C (en
Inventor
Erik M. Erbe
Theodore D. Clineff
Charanpreet S. Bagga
Gina M. Nagvajara
Antony Koblish
Steven B. Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orthovita Inc
Original Assignee
Vita Special Purpose Corporation
Erik M. Erbe
Theodore D. Clineff
Charanpreet S. Bagga
Gina M. Nagvajara
Antony Koblish
Steven B. Brown
Vita Licensing, Inc.
Orthovita, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Special Purpose Corporation, Erik M. Erbe, Theodore D. Clineff, Charanpreet S. Bagga, Gina M. Nagvajara, Antony Koblish, Steven B. Brown, Vita Licensing, Inc., Orthovita, Inc. filed Critical Vita Special Purpose Corporation
Publication of CA2556183A1 publication Critical patent/CA2556183A1/en
Application granted granted Critical
Publication of CA2556183C publication Critical patent/CA2556183C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
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    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/54—Biologically active materials, e.g. therapeutic substances
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Abstract

Biocompatible bone graft material having a biocompatible, resorbable polymer and a biocompatible, resorbable inorganic material exhibiting macro, meso, and microporosities are described herein (Figure 2). A pliable bone restorative having an osteoconductive foam that at least partially surrounds a biocompatible mesh and the foam comprises a biocompatible, resorbable polymer and calcium phosphate is also described.

Claims (174)

1. A biocompatible bone graft material comprising a biocompatible, resorbable polymer, and the oxidation-reduction reaction product of at least one metal cation, at least one oxidizing agent, and at least one oxidizable precursor anion.
2. The graft material of claim 1 wherein said polymer is collagen.
3. The graft material of claim 1 wherein the polymer is at least 85% Type I
bovine collagen.
4. The graft material of claim 3 wherein said Type I bovine collagen is native fibrous collagen, soluble collagen, reconstituted collagen, or combinations thereof.
5. The graft material of claim 4 wherein said Type I bovine collagen is predominantly fibrous collagen.
6. The graft material of claim 2 wherein the reaction product and collagen have a mass ratio of about 70:30.
7. The graft material of claim 2 wherein the reaction product and collagen have a mass ratio of about 80:20.
8. The graft material of claim 2 wherein said reaction product and collagen have a mass ratio of about 90:10.
9. The graft material of claim 1 having up to about 30% by weight of biocompatible polymer.
10. The graft material of claim 1 having up to about 20% by weight of biocompatible polymer.
11. The graft material of claim 1 having up to about 10% by weight of biocompatible polymer.
12. The graft material of claim 1 having macro-, meso-, and microporosity.
13. The graft material of claim 1 wherein said reaction product is calcium phosphate.
14. The graft material of claim 1 wetted with a fluid comprising bone marrow aspirate, blood, or saline.
15. The graft material of claim 1 having a cylindrical, block, or discoid shape.
16. The graft material of claim 1 further comprising a mesh or plate.
17. The graft material of claim 16 comprising a mesh or plate comprised of a metal or polymer.
18. A biocompatible bone graft material comprising biocompatible, resorbable collagen, and calcium phosphate.
19. The bone graft material of claim 18 wherein said collagen is at least 85%
Type I
bovine collagen.
20. The bone graft material of claim 19 wherein said Type I bovine collagen is a mixture of native fibrous collagen, soluble collagen, or reconstituted collagen.
21. The bone graft material of claim 18 wherein said reaction product and collagen have a mass ratio of about 70:30.
22. The bone graft material of claim 18 wherein said reaction product and collagen have a mass ratio of about 80:20.
23. The bone graft material of claim 18 wherein said reaction product and collagen have a mass ratio of about 90:10.
24. The bone graft material of claim 18 having up to about 30% by weight of collagen.
25. The bone graft material of claim 18 having up to about 20% by weight of collagen.
26. The bone graft material of claim 18 having up to about 10% by weight of collagen.
27. The bone graft material of claim 18 having macro-, meso-, and microporosity.
28. The bone graft material of claim 18 wetted with a fluid comprising bone marrow aspirate, blood, or saline.
29. The bone graft material of claim 18 having a cylindrical, block, or discoid shape.
30. The bone graft material of claim 18 also comprising a mesh or plate.
31. The bone graft material of claim 30 comprising a mesh or plate comprised of a metal or polymer.
32. A biocompatible bone graft material comprising biocompatible, resorbable collagen and calcium phosphate having macro-, meso-, and microporosity.
33. The bone graft material of claim 32 wherein said collagen is Type I bovine collagen.
34. The bone graft material of claim 32 wherein said phosphate and collagen have a mass ratio of about 90:10 to about 70:30.
35. The bone graft material of claim 34 wherein said phosphate and collagen have a mass ratio of about 85:15 to about 75:25
36. The bone graft material of claim 32 having up to about 30% by weight of collagen.
37. The bone graft material of claim 32 having up to about 20% by weight of collagen.
38. The bone graft material of claim 32 having up to about 10% by weight of collagen.
39. The bone graft material of claim 32 wetted with a fluid comprising bone marrow aspirate, blood, or saline.
40. The bone graft material of claim 32 having a cylindrical, block, or discoid shape.
41. The bone graft material of claim 32 also comprising a metal mesh.
42. The bone graft material of claim 41 wherein said metal comprises titanium.
43. The bone graft material of claim 32 wherein the bone graft material is shredded.
44. A composite biocompatible graft comprising a biocompatible, resorbable substantially homogenous blend of a first polymeric material and a second material having interconnected macro-, meso- and microporosity.
45. The graft of claim 44 wherein the polymeric material is Type I bovine collagen.
46. The graft of claim 44 having up to about 80% of the second material.
47. The graft of claim 46 having a total porosity of at least 70%.
48. The graft of claim 47 wherein the second material is beta tri-calcium phosphate.
49. The graft of claim 47 further comprising a titanium mesh affixed to the graft.
50. A method for restoring or repairing bone in a mammal comprising:
- placing into a bony space a bone graft material comprising biocompatible, resorbable collagen, the oxidation-reduction reaction product of at least one metal cation, at least one oxidizing agent, and at least one oxidizable precursor anion.
51. The method of claim 50 wherein said collagen is at least 85% Type I bovine collagen.
52. The method of claim 51 wherein said Type I bovine collagen is a mixture of native fibrous collagen, soluble collagen, or reconstituted collagen.
53. The method of claim 50 wherein said reaction product and collagen have a mass ratio of about 90:10 to about 70:30.
54. The method of claim 50 wherein said reaction product and collagen have a mass ratio of about 85:15 to about 75:25.
55. The method of claim 50 having up to about 30% by weight of collagen.
56. The method of claim 50 having up to about 20% by weight of collagen.
57. The method of claim 50 having up to about 10% by weight of collagen.
58. The method of claim 50 wherein said graft material has macro-, meso-, and microporosity.
59. The method of claim 50 wherein said reaction product is calcium phosphate.
60. The method of claim 50 further comprising allowing said graft material to be wetted with a fluid comprising bone marrow aspirate, blood, or saline.
61. The method of claim 50 wherein said graft material has a cylindrical, block, or discoid shape.
62. The method of claim 50 also comprising a mesh or plate comprised of a metal or polymer.
63. A bone graft for long bone reinforcement comprising a biocompatible, resorbable sleeve of a polymer and beta-tricalcium phosphate, the graft having interconnected macro-, meso-, and microporosity.
64. The bone graft of claim 63 further comprising a mesh affixed to the surface of the sleeve.
65. The bone graft of claim 63 wherein said mesh is immersed in the graft.
66. The bone graft of claim 64 wherein the mesh is of titanium, stainless steel, nitinol, a composite polymer, or polyetheretherketone.
67. The bone graft of claim 63 wherein the polymer is collagen.
68. The bone graft of claim 63 wherein the beta-tricalcium phosphate and polymer are in a mass ratio of about 90:10 to about 70:10.
69. The bone graft of claim 69 wherein the beta-tricalcium phosphate and polymer are in a mass ratio of about 85:15 to about 75:25.
70. The bone graft of claim 63 wherein the cross-section of the sleeve is in the shape of a crescent shape moon.
71. A graft for the restoration of bone in the form of a shaped body, the shaped body comprising a polymer and beta-tricalcium phosphate, the graft having interconnected macro-, meso-, and microporosity; the body shape being selected to conform generally to a mammalian, anatomical tissue structure.
72. The graft of claim 72 further comprising a mesh affixed to a side of the polymer.
73. The graft of claim 73 wherein the mesh is of titanium, stainless steel, nitinol, a composite polymer, or polyetheretherketone.
74. The graft of claim 72 wherein the polymer is collagen.
75. The graft of claim 72 wherein the body shape is a disk, semi-sphere, semi-tubular, or torus.
76. The graft of claim 72 wherein the body shape conforms to the acetabulum.
77. The graft of claim 72 wherein the beta-tricalcium phosphate and polymer are in a mass ratio of about 90:10 to about 70:10.
78. The graft of claim 77 wherein the beta-tricalcium phosphate and polymer are in a mass ratio of about 85:15 to about 75:25.
79. A pliable bone restorative comprising an osteoconductive foam comprising biocompatible, resorbable polymer and calcium phosphate that at least partially surrounds a biocompatible mesh.
80. The bone restorative of claim 79 wherein said polymer is collagen.
81. The bone restorative of claim 79 having macro-, meso-, and microporosity.
82. The bone restorative of claim 79 wetted with a fluid comprising bone marrow aspirate, cell concentrate, liquid hemostat, fibrin sealant, blood, or saline.
83. The bone restorative of claim 79 having a cylindrical, block, wedge, sheet, hemisphere, half pipe, rod, funnel, or discoid shape.
84. The bone restorative of claim 79 wherein said mesh comprises titanium, stainless steel, nitinol, a composite polymer, or polyetheretherketone.
85. The bone restorative of claim 84 wherein said mesh comprises acid etched titanium or sodium treated titanium.
86. The bone restorative of claim 79 wherein said restorative is coated with titanium plasma spray.
87. The bone restorative of claim 79 that is radiopaque.
88. The bone restorative of claim 79 wherein said foam completely surrounds said mesh.
89. A pliable bone restorative comprising a biocompatible mesh and at least partially surrounding said mesh, a biocompatible, resorbable polymer, and the oxidation-reduction reaction product of at least one metal cation, at least one oxidizing agent, and at least one oxidizable precursor anion.
90. The bone restorative of claim 89 wherein said polymer is collagen.
91. The bone restorative of claim 89 having macro-, meso-, and microporosity.
92. The bone restorative of claim 89 wherein said reaction product is calcium phosphate.
93. The bone restorative of claim 89 wetted with a fluid comprising bone marrow aspirate, cell concentrate, liquid hemostat, fibrin sealant, blood, or saline.
94. The bone restorative of claim 89 having a cylindrical, block, wedge, sheet, hemisphere, half pipe, rod, funnel, or discoid shape.
95. The bone restorative of claim 79 wherein said mesh comprises titanium, stainless steel, nitinol, a composite polymer, or polyetheretherketone. (17)
96. The bone restorative of claim 95 wherein said mesh comprises acid etched titanium or sodium treated titanium.
97. The bone restorative of claim 79 wherein said restorative is coated with titanium plasma spray.
98. The bone restorative of claim 79 that is radiopaque.
99. A pliable bone restorative comprising a biocompatible mesh and a bone graft material comprising biocompatible, resorbable collagen and calcium phosphate.
100. The bone restorative of claim 21 having macro-, meso-, and microporosity.
101. The bone restorative of claim 21 wetted with a fluid comprising bone marrow aspirate, cell concentrate, liquid hemostat, fibrin sealant, blood, or saline.
102. The bone restorative of claim 21 having a cylindrical, block, wedge, sheet, hemisphere, half pipe, rod, funnel, or discoid shape.
103. The bone restorative of claim 21 wherein said mesh comprises titanium, stainless steel, nitinol, a composite polymer, or polyetheretherketone.
104. The bone restorative of claim 103 wherein said mesh comprises acid etched titanium or sodium treated titanium.
105. The bone restorative of claim 21 wherein said restorative is coated with titanium plasma spray.
106. The bone restorative of claim 21 that is radiopaque.
107. A pliable bone restorative comprising a biocompatible mesh and a biocompatible bone graft material comprising biocompatible, resorbable collagen and calcium phosphate having macro, meso, and microporosity.
108. The bone restorative of claim 107 wetted with a fluid comprising bone marrow aspirate, cell concentrate, liquid hemostat, fibrin sealant, blood, or saline.
109. The bone restorative of claim 107 having a cylindrical, block, wedge, sheet, hemisphere, half pipe, rod, funnel, or discoid shape.
110. The bone restorative of claim 107 wherein said mesh comprises titanium, stainless steel, nitinol, a composite polymer, or polyetheretherketone.
111. The bone restorative of claim 110 wherein said mesh comprises acid etched titanium or sodium treated titanium.
112. The bone restorative of claim 107 wherein said restorative is coated with titanium plasma spray.
113. The bone restorative of claim 107 that is radiopaque.
114. A pliable bone restorative comprising a biocompatible, resorbable substantially homogenous blend of a first polymeric material and a second material having interconnected macro, meso-, and microporosity, said blend at least partially surrounding a biocompatible mesh with said bone restorative.
115. The bone restorative of claim 114 wherein said polymeric material is collagen.

95. The bone restorative of claim 79 wherein said mesh comprises titanium, stainless steel, nitinol, a composite polymer, or polyetheretherketone. (17) 96. The bone restorative of claim 95 wherein said mesh comprises acid etched titanium or sodium treated titanium.
97. The bone restorative of claim 79 wherein said restorative is coated with titanium plasma spray.
98. The bone restorative of claim 79 that is radiopaque.
99. A pliable bone restorative comprising a biocompatible mesh and a bone graft material comprising biocompatible, resorbable collagen and calcium phosphate.
100. The bone restorative of claim 21 having macro-, meso-, and microporosity.
101. The bone restorative of claim 21 wetted with a fluid comprising bone marrow aspirate, cell concentrate, liquid hemostat, fibrin sealant, blood, or saline.
102. The bone restorative of claim 21 having a cylindrical, block, wedge, sheet, hemisphere, half pipe, rod, funnel, or discoid shape.
103. The bone restorative of claim 21 wherein said mesh comprises titanium, stainless steel, nitinol, a composite polymer, or polyetheretherketone.
104. The bone restorative of claim 103 wherein said mesh comprises acid etched titanium or sodium treated titanium.
105. The bone restorative of claim 21 wherein said restorative is coated with titanium plasma spray.

106. The bone restorative of claim 21 that is radiopaque.
107. A pliable bone restorative comprising a biocompatible mesh and a biocompatible bone graft material comprising biocompatible, resorbable collagen and calcium phosphate having macro, meso, and microporosity.
108. The bone restorative of claim 107 wetted with a fluid comprising bone marrow aspirate, cell concentrate, liquid hemostat, fibrin sealant, blood, or saline.
109. The bone restorative of claim 107 having a cylindrical, block, wedge, sheet, hemisphere, half pipe, rod, funnel, or discoid shape.
110. The bone restorative of claim 107 wherein said mesh comprises titanium, stainless steel, nitinol, a composite polymer, or polyetheretherketone.
111. The bone restorative of claim 110 wherein said mesh comprises acid etched titanium or sodium treated titanium.
112. The bone restorative of claim 107 wherein said restorative is coated with titanium plasma spray.
113. The bone restorative of claim 107 that is radiopaque.
114. A pliable bone restorative comprising a biocompatible, resorbable substantially homogenous blend of a first polymeric material and a second material having interconnected macro, meso-, and microporosity, said blend at least partially surrounding a biocompatible mesh with said bone restorative.
115. The bone restorative of claim 114 wherein said polymeric material is collagen.
116. The bone restorative of claim 115 wherein said second material comprises calcium phosphate.
117. The bone restorative of claim 115 wetted with a fluid comprising bone marrow aspirate, cell concentrate, liquid hemostat, fibrin sealant, blood, or saline.
118. The bone restorative of claim 115 having a cylindrical, block, wedge, sheet, hemisphere, half pipe, rod, funnel, or discoid shape.
119. The bone restorative of claim 115 wherein said mesh comprises titanium, stainless steel, nitinol, a composite polymer, or polyetheretherketone.
120. The bone restorative of claim 119 wherein said mesh comprises acid etched titanium or sodium treated titanium.
121. The bone restorative of claim 115 wherein said restorative is coated with titanium plasma spray.
122. The bone restorative of claim 115 that is radiopaque.
123. A pliable bone restorative for the restoration of bone in the form of a shaped body, the shaped body selected to conform generally to a mammalian, anatomical tissue structure, said body comprising a polymer and beta tricalcium phosphate, and partially surrounding a biocompatible mesh; the bone restorative having interconnected macro-, meso-, and microporosity.
124. The bone restorative of claim 123 wherein said polymer comprises collagen.
125. The bone restorative of claim 123 having a cylindrical, block, wedge, sheet, hemisphere, half pipe, rod, funnel, or discoid shape.
126. The bone restorative of claim 123 wetted with a fluid comprising bone marrow aspirate, cell concentrate, liquid hemostat, fibrin sealant, blood, or saline.
127. The bone restorative of claim 123 wherein said mesh comprises titanium, stainless steel, nitinol, a composite polymer, or polyetheretherketone.
128. The bone restorative of claim 127 wherein said mesh comprises acid etched titanium or sodium treated titanium.
129. The bone restorative of claim 123 wherein said restorative is coated with titanium plasma spray.
130. The bone restorative of claim 123 that is radiopaque.
131. A method for delivering therapeutic material comprising providing a bone restorative comprising biocompatible, resorbable polymer, the oxidation-reduction reaction product of at least one metal cation, at least one oxidizing agent, and at least one oxidizable precursor anion;
- imbibing said bone restorative with a therapeutic material; and - placing said bone restorative into a bony space.
132. The method of claim131 wherein said therapeutic material comprises blood, cells, protein rich plasma, growth hormones, antibiotics, cell signaling materials, anti-bone resoprtion drugs, chemotherapeutic agents, chemicals, genes, chemicals, genes, fibrin sealants, liquid hemostats, vectors, vitamin D, or sodium fluoride.
133. The method of claim 132 wherein said cells comprise fibroblasts, mesenchymal, stromal, marrow, adipose, myoblast, lyosomes, or stem cells.
134. The method of claim131 wherein said polymer is collagen.
135. The method of claiml3l wherein said reaction product is calcium phosphate.
136. The method of claim131 wherein said reaction product is .beta.-tricalcium phosphate.
137. The method of claim131 wherein said bone restorative comprises wells or channels.
138. The method of claim 137 wherein said wells or channels contain therapeutic material or admixtures of autogenous bone chips and synthetic bone grafts.
139. The method of claim131 further comprising releasing said therapeutic materials over time.
140. The method of claiml3l wherein the therapeutic material is imbibed in a 1:1 volume with the bone restorative.
141. A method for delivering therapeutic material comprising - providing a bone restorative comprising biocompatible, resorbable collagen, the oxidation-reduction reaction product of at least one metal cation, at least one oxidizing agent, and at least one oxidizable precursor anion;
- imbibing said bone restorative with a therapeutic material; and - placing said bone restorative into a bony space.
142. The method of claim 141 wherein said therapeutic material comprises blood, cells, protein rich plasma, growth hormones, antibiotics, cell signaling materials, anti-bone resoprtion drugs, chemotherapeutic agents, chemicals, genes, chemicals, genes, fibrin sealants, liquid hemostats, vectors, vitamin D, or sodium fluoride.
143. The method of claim 141 wherein said cells comprise fibroblasts, mesenchymal, stromal, marrow, adipose, myoblast, lyosomes, or stem cells.
144. The method of claim 141 wherein said reaction product is calcium phosphate.
145. The method of claim 141 wherein said reaction product is .beta.-tricalcium phosphate.
146. The method of claim 141 wherein said bone restorative comprises wells or channels.
147. The method of claim 146 wherein said wells or channels contain therapeutic material or admixtures of autogenous bone chips and synthetic bone grafts.
148. The method of claim 141 further comprising releasing said therapeutic materials over time.
149. The method of claim 141 wherein the therapeutic material is imbibed in a 1:1 volume with the bone restorative.
150. A method for delivering therapeutic material comprising - providing a pliable bone restorative comprising biocompatible, resorbable collagen and calcium phosphate;
- imbibing said bone restorative with said therapeutic material; and - placing said bone restorative into a bony space.
151. The method of claim 150 wherein said therapeutic material comprises blood, cells, protein rich plasma, growth hormones, antibiotics, cell signaling materials, anti-bone resoprtion drugs, chemotherapeutic agents, chemicals, genes, chemicals, genes, fibrin sealants, liquid hemostats, vectors, vitamin D, or sodium fluoride.
152. The method of claim 150 wherein said cells comprise fibroblasts, mesenchymal, stromal, marrow, adipose, myoblast, lyosomes, or stem cells.
153. The method of claim 150 wherein said calcium phosphate is .beta.-tricalcium phosphate.
154. The method of claim 150 wherein said bone restorative comprises wells or channels.
155. The method of claim 154 wherein said wells or channels contain therapeutic material or admixtures of autogenous bone chips and synthetic bone grafts.
156. The method of claim 150 further comprising releasing said therapeutic materials over time.
157. The method of claim 150 wherein the therapeutic material is imbibed in a 1:1 volume with the bone restorative
158. A method for delivering therapeutic material comprising - providing a pliable bone restorative comprising biocompatible, resorbable collagen and calcium phosphate having macro-, meso-, and microporosity;
- imbibing said bone restorative with a therapeutic fluid; and - placing said bone restorative into a bony space.
159. The method of claim 158 wherein said therapeutic material comprises blood, cells, protein rich plasma, growth hormones, antibiotics, cell signaling materials, anti-bone resoprtion drugs, chemotherapeutic agents, chemicals, genes, chemicals, genes, fibrin sealants, liquid hemostats, vectors, vitamin D, or sodium fluoride.
160. The method of claim 158 wherein said cells comprise fibroblasts, mesenchymal, stromal, marrow, adipose, myoblast, lyosomes, or stem cells.
161. The method of claim 158 wherein said reaction product is calcium phosphate.
162. The method of claim 158 wherein said reaction product is .beta.-tricalcium phosphate.
163. The method of claim 158 wherein said bone restorative comprises wells or channels.
164. The method of claim 163 wherein said wells or channels contain therapeutic material or admixtures of autogenous bone chips and synthetic bone grafts.
165. The method of claim 158 further comprising releasing said therapeutic materials over time.
166. The method of claim 158 wherein the therapeutic material is imbibed in a 1:1 volume with the bone restorative
167. A method for delivering therapeutic material comprising - ductile bone restorative comprising a biocompatible mesh and a bone graft material comprising biocompatible, resorbable collagen and calcium phosphate and wells for containing therapeutic materials;
- imbibing said bone restorative with a therapeutic fluid; and - placing said bone restorative into a bony space.
168. The method of claim 167 wherein said therapeutic material comprises blood, cells, protein rich plasma, growth hormones, antibiotics, cell signaling materials, anti-bone resoprtion drugs, chemotherapeutic agents, chemicals, genes, chemicals, genes, fibrin sealants, liquid hemostats, vectors, vitamin D, or sodium fluoride.
169. The method of claim 167 wherein said cells comprise fibroblasts, mesenchymal, stromal, marrow, adipose, myoblast, lyosomes, or stem cells.
170. The method of claim 167 wherein said reaction product is .beta.-tricalcium phosphate.
171. The method of claim 167 wherein said bone restorative comprises wells or channels.
172. The method of claim 171 wherein said wells or channels contain therapeutic material or admixtures of autogenous bone chips and synthetic bone grafts.
173. The method of claim 167 further comprising releasing said therapeutic materials over time.
174. The method of claim 167 wherein the therapeutic material is imbibed in a 1:1 volume with the bone restorative
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US10/771,077 US7189263B2 (en) 2004-02-03 2004-02-03 Biocompatible bone graft material
US10/973,972 US7531004B2 (en) 2004-02-03 2004-10-26 Pliable conformable bone restorative
US10/973,781 US7534451B2 (en) 2004-02-03 2004-10-26 Bone restorative carrier mediums
US10/973,972 2004-10-26
US10/973,781 2004-10-26
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