CA2557029A1 - Metal implants - Google Patents
Metal implants Download PDFInfo
- Publication number
- CA2557029A1 CA2557029A1 CA002557029A CA2557029A CA2557029A1 CA 2557029 A1 CA2557029 A1 CA 2557029A1 CA 002557029 A CA002557029 A CA 002557029A CA 2557029 A CA2557029 A CA 2557029A CA 2557029 A1 CA2557029 A1 CA 2557029A1
- Authority
- CA
- Canada
- Prior art keywords
- surface layer
- anodising
- metal
- biocidal
- implant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/32—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C28/00—Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D
- C23C28/04—Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D only coatings of inorganic non-metallic material
- C23C28/042—Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D only coatings of inorganic non-metallic material including a refractory ceramic layer, e.g. refractory metal oxides, ZrO2, rare earth oxides
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
- C25D11/02—Anodisation
- C25D11/26—Anodisation of refractory metals or alloys based thereon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Metallurgy (AREA)
- Materials Engineering (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Ceramic Engineering (AREA)
- Mechanical Engineering (AREA)
- Electrochemistry (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
Abstract
A metal implant for use in a surgical procedure is provided with a surface layer that is integral with the metal substrate, and which incorporates a biocidal material. The surface layer is grown by anodizing at a voltage between 50 and 150 V, and the biocidal material incorporated in it by ion exchange. This produces a significantly harder surface than anodizing at low voltage, and generates pits containing ion-absorbing material.
Claims (6)
1. A method of treating a titanium metal implant for use in a surgical procedure, so as to form a surface layer that is integral with the metal substrate and which incorporates a biocidal material, wherein the method comprises anodising the implant at a voltage above 50 V
for a period of at least 30 min, so as to generate a surface layer, and then performing ion exchange so as to incorporate ions of a biocidal metal into the surface layer.
for a period of at least 30 min, so as to generate a surface layer, and then performing ion exchange so as to incorporate ions of a biocidal metal into the surface layer.
2. A method as claimed in claim 1 wherein the anodising is performed so as to generate a dense hard surface layer and also shallow pits in the surface which are filled with a somewhat softer and more porous material, and wherein the magnitude of the anodising voltage and its duration are controlled, so as to control the number and size of the shallow pits.
3. A method as claimed in claim 1 or claim 2 wherein the the biocidal metal is silver.
4. A method as claimed in any one of the preceding claims wherein the anodising step uses an electrolyte comprising phosphoric acid.
5. A method as claimed in claim 4 wherein the phosphoric acid is of concentration between 5% and 20% by weight.
6. A method as claimed in claim 4 or claim 5 wherein the electrolyte comprises chloride ions at a concentration no more than 500 ppm.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0405680.0A GB0405680D0 (en) | 2004-03-13 | 2004-03-13 | Metal implants |
GB0405680.0 | 2004-03-13 | ||
PCT/GB2005/000645 WO2005087982A1 (en) | 2004-03-13 | 2005-03-03 | Metal implants |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2557029A1 true CA2557029A1 (en) | 2005-09-22 |
CA2557029C CA2557029C (en) | 2012-01-03 |
Family
ID=32117618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2557029A Expired - Fee Related CA2557029C (en) | 2004-03-13 | 2005-03-03 | Metal implants |
Country Status (11)
Country | Link |
---|---|
US (1) | US9011665B2 (en) |
EP (1) | EP1725701B1 (en) |
JP (1) | JP4690386B2 (en) |
KR (1) | KR101089053B1 (en) |
AT (1) | ATE372401T1 (en) |
AU (1) | AU2005221862C1 (en) |
CA (1) | CA2557029C (en) |
DE (1) | DE602005002353T2 (en) |
ES (1) | ES2290888T3 (en) |
GB (1) | GB0405680D0 (en) |
WO (1) | WO2005087982A1 (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0208642D0 (en) | 2002-04-16 | 2002-05-22 | Accentus Plc | Metal implants |
US20060147332A1 (en) | 2004-12-30 | 2006-07-06 | Howmedica Osteonics Corp. | Laser-produced porous structure |
US7537664B2 (en) | 2002-11-08 | 2009-05-26 | Howmedica Osteonics Corp. | Laser-produced porous surface |
GB0405680D0 (en) | 2004-03-13 | 2004-04-21 | Accentus Plc | Metal implants |
ITTO20040854A1 (en) * | 2004-12-02 | 2005-03-02 | Torino Politecnico | WORKING PROCEDURE FOR GLASS, CERAMIC AND GLASS SURFACES FOR THE IMPLEMENTATION OF IMPLANTABLE DEVICES WITH ANTIBACTERIAL ACTION |
US8728387B2 (en) | 2005-12-06 | 2014-05-20 | Howmedica Osteonics Corp. | Laser-produced porous surface |
EP2026852B1 (en) * | 2006-06-12 | 2011-01-12 | Accentus Medical plc | Metal implants |
GB0611437D0 (en) * | 2006-06-12 | 2006-07-19 | Accentus Plc | Metal implants |
GB0700713D0 (en) * | 2007-01-15 | 2007-02-21 | Accentus Plc | Metal implants |
US8147861B2 (en) * | 2006-08-15 | 2012-04-03 | Howmedica Osteonics Corp. | Antimicrobial implant |
ATE477006T1 (en) * | 2007-01-15 | 2010-08-15 | Accentus Medical Plc | METAL IMPLANTS |
WO2009014718A1 (en) | 2007-07-24 | 2009-01-29 | Porex Corporation | Porous laser sintered articles |
PL2198076T3 (en) * | 2007-10-03 | 2016-09-30 | Method of manufacturing metal with biocidal properties | |
DE102008008517B4 (en) * | 2008-02-11 | 2014-12-31 | Stryker Trauma Gmbh | Antimicrobial finish of titanium and titanium alloys with silver |
US20090204213A1 (en) * | 2008-02-13 | 2009-08-13 | Depuy Products, Inc. | Metallic implants |
JP2009189683A (en) * | 2008-02-18 | 2009-08-27 | Saga Univ | Living body implant |
DE102008026558B4 (en) | 2008-06-03 | 2010-04-01 | Königsee Implantate und Instrumente zur Osteosynthese GmbH | Electrochemical immersion process in an aqueous electrolyte to produce a biologically degradable surface layer on bases of titanium or titanium-based alloys |
DE102008026557A1 (en) | 2008-06-03 | 2009-12-17 | Königsee Implantate und Instrumente zur Osteosynthese GmbH | Electrochemically produced, biodegradation-stable, ductile and adherent titanium oxide surface layer on titanium or titanium-based alloys |
DE102008043970A1 (en) * | 2008-11-21 | 2010-05-27 | Biotronik Vi Patent Ag | A method for producing a corrosion-inhibiting coating on an implant of a biocorrodible magnesium alloy and implant produced by the method |
WO2010112908A1 (en) * | 2009-03-30 | 2010-10-07 | Accentus Plc | Metal treatment |
GB0905354D0 (en) * | 2009-03-30 | 2009-05-13 | Accentus Plc | Metal treatment |
US20140335142A1 (en) * | 2009-04-02 | 2014-11-13 | Smith & Nephew Orthopaedics Ag | Method of surface treatment of an implant, an implant treated by said method and an electrolyte solution for use in said method |
GB201009772D0 (en) * | 2010-06-11 | 2010-07-21 | Accentus Plc | Metal treatment |
JP2013034507A (en) * | 2011-08-03 | 2013-02-21 | Hoya Corp | Spacer fixing member and spacer with spacer fixing member |
JP5864955B2 (en) * | 2011-08-29 | 2016-02-17 | HOYA Technosurgical株式会社 | Spacer fixing tool and spacer with spacer fixing tool |
US9364896B2 (en) | 2012-02-07 | 2016-06-14 | Medical Modeling Inc. | Fabrication of hybrid solid-porous medical implantable devices with electron beam melting technology |
US9135374B2 (en) | 2012-04-06 | 2015-09-15 | Howmedica Osteonics Corp. | Surface modified unit cell lattice structures for optimized secure freeform fabrication |
US9180010B2 (en) | 2012-04-06 | 2015-11-10 | Howmedica Osteonics Corp. | Surface modified unit cell lattice structures for optimized secure freeform fabrication |
JP2013236700A (en) * | 2012-05-14 | 2013-11-28 | Chube Univ | Antibacterial bone repair material and method of manufacturing the same |
US9586381B1 (en) | 2013-10-25 | 2017-03-07 | Steriplate, LLC | Metal plated object with biocidal properties |
GB201508385D0 (en) * | 2015-05-15 | 2015-07-01 | Accentus Medical Ltd | Metal treatment |
US11135339B2 (en) | 2016-01-25 | 2021-10-05 | Smith & Nephew, Inc. | Orthopaedic implant |
EP3981444A1 (en) | 2017-03-30 | 2022-04-13 | Biomet Manufacturing, LLC | Methods of modifying the porous surface of implants |
EP3586882B1 (en) * | 2017-03-31 | 2023-02-22 | Prostec Co., Ltd. | Antibacterial biological implant |
WO2018179358A1 (en) * | 2017-03-31 | 2018-10-04 | 株式会社プロステック | Method for producing antibacterial biological implant |
US11298747B2 (en) | 2017-05-18 | 2022-04-12 | Howmedica Osteonics Corp. | High fatigue strength porous structure |
US11761068B2 (en) | 2019-11-22 | 2023-09-19 | Blue Point Materials Research LLC | 3D printable stainless steel alloy with antibacterial properties for orthopedic implants |
Family Cites Families (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4027393A (en) | 1975-09-19 | 1977-06-07 | Sybron Corporation | Method of in vivo sterilization of surgical implantables |
GB1602375A (en) | 1977-06-02 | 1981-11-11 | Johnson Matthey Co Ltd | Coating of metals |
JPS56102239A (en) | 1980-01-21 | 1981-08-15 | Shinetsu Chem Ind Co | Member for replacing live body prosthetics |
GB2072514B (en) | 1980-03-27 | 1984-02-29 | Nat Res Dev | Orthopaedic implants |
JPS57500589A (en) | 1980-03-27 | 1982-04-08 | ||
US4476590A (en) | 1980-03-27 | 1984-10-16 | National Research Development Corporation | Antimicrobial surgical implants |
GB2073024B (en) | 1980-03-27 | 1984-06-27 | Nat Res Dev | Antimicrobial surgical implants |
JPS58167798A (en) | 1982-03-29 | 1983-10-04 | Pilot Precision Co Ltd | Film for preventing fouling of ocean organism and preparation thereof |
JPS59171023A (en) | 1983-03-18 | 1984-09-27 | Nippon Light Metal Co Ltd | Manufacture of alumite board for high density magnetic recording material |
DD243855B1 (en) | 1985-12-05 | 1991-09-19 | Chemnitz Tech Hochschule | ACTIVE IMPLANT |
JPS62182298A (en) | 1986-01-17 | 1987-08-10 | Nippon Alum Mfg Co Ltd:The | Aluminum product having antibacterial or antimold anodic oxide film |
DD246028A1 (en) | 1986-02-12 | 1987-05-27 | Karl Marx Stadt Tech Hochschul | CERAMIZED METAL IMPLANT |
US4784160A (en) | 1986-08-19 | 1988-11-15 | Cordis Corporation | Implantable device having plasma sprayed ceramic porous surface |
GB8620469D0 (en) | 1986-08-22 | 1986-10-01 | Atomic Energy Authority Uk | Prostheses |
DE3630224C2 (en) | 1986-09-05 | 1994-01-05 | Nokia Deutschland Gmbh | Process for the production of oxide cathode wires by cataphoretic coating |
CA1269898A (en) | 1986-10-17 | 1990-06-05 | Takayuki Shimamune | Process for production of calcium phosphate compound- coated composite material |
US4813965A (en) | 1988-02-29 | 1989-03-21 | Nuclear Metals, Inc. | Brazed porous coating and improved method of joining metal with silver material |
US4938409A (en) | 1988-02-29 | 1990-07-03 | Nuclear Metals, Inc. | Brazed porous coating and improved method of joining metal with silver material |
JPH02301596A (en) | 1989-05-16 | 1990-12-13 | Minoru Mitani | Surface treatment of aluminum or alloy thereof |
US5185075A (en) | 1990-10-25 | 1993-02-09 | The Alta Group | Surface treated titanium/titanium alloy articles and process for producing |
CA2033107C (en) | 1990-12-24 | 2001-06-12 | Robert Edward Burrell | Actively sterile surfaces |
US5310464A (en) | 1991-01-04 | 1994-05-10 | Redepenning Jody G | Electrocrystallization of strongly adherent brushite coatings on prosthetic alloys |
US5468562A (en) | 1991-03-01 | 1995-11-21 | Spire Corporation | Metallized polymeric implant with ion embedded coating |
US5520664A (en) | 1991-03-01 | 1996-05-28 | Spire Corporation | Catheter having a long-lasting antimicrobial surface treatment |
US5211663A (en) | 1991-06-24 | 1993-05-18 | Smith & Nephew Richards, Inc. | Passivation methods for metallic medical implants |
WO1993007924A1 (en) | 1991-10-18 | 1993-04-29 | Spire Corporation | Bactericidal coatings for implants |
GB9202248D0 (en) | 1992-02-03 | 1992-03-18 | Howmedica | Prosthesis for attachement without bone cement and method of attaching |
US5478237A (en) | 1992-02-14 | 1995-12-26 | Nikon Corporation | Implant and method of making the same |
US5211832A (en) * | 1992-04-22 | 1993-05-18 | The Alta Group | Process for producing electrically impervious anodized films on valve metals and product thereof |
FI91713C (en) | 1992-04-23 | 1994-08-10 | Axidental Oy | New bioactive coatings and their manufacture and use |
US5681575A (en) | 1992-05-19 | 1997-10-28 | Westaim Technologies Inc. | Anti-microbial coating for medical devices |
GEP20002074B (en) | 1992-05-19 | 2000-05-10 | Westaim Tech Inc Ca | Modified Material and Method for its Production |
US5492763A (en) | 1992-06-08 | 1996-02-20 | Spire Corporation | Infection resistant medical devices and process |
US5503704A (en) | 1993-01-06 | 1996-04-02 | The Regents Of The University Of California | Nitrogen based low temperature direct bonding |
CA2136456C (en) | 1993-11-18 | 1999-06-29 | Robert Edward Burrell | Novel anti-microbial materials |
RU2167526C2 (en) | 1993-11-18 | 2001-05-27 | Вестейм Биомедикал Корп. | Antibacterial materials |
UA46720C2 (en) | 1993-11-18 | 2002-06-17 | Накріст Фармасьютікалз Корп. | METHOD FOR PRODUCING ANTIMICROBIAL MATERIAL way to achieve antimicrobial effect, antimicrobial FORM SILVER MATERIAL grained antimicrobial materials and fine-grained antimicrobial METHOD FOR PRODUCING MATERIAL |
AU731732B2 (en) | 1993-11-18 | 2001-04-05 | Smith & Nephew (Overseas) Limited | Anti-microbial materials |
AU731730B2 (en) | 1993-11-18 | 2001-04-05 | Nucryst Pharmaceuticals Corp. | Process for producing anti-microbial effect with complex silver ions |
CA2136455C (en) | 1993-11-18 | 1999-06-29 | Robert Edward Burrell | Process for producing anti-microbial effect with complex silver ions |
US5454886A (en) | 1993-11-18 | 1995-10-03 | Westaim Technologies Inc. | Process of activating anti-microbial materials |
US5482731A (en) | 1994-04-29 | 1996-01-09 | Centro De Investigacion Y De Estudios Avanzados Del Ipn | Method for bonding a calcium phosphate coating to stainless steels and cobalt base alloys for bioactive fixation of artificial implants |
US5486231A (en) * | 1994-05-02 | 1996-01-23 | Dulaney; Donald C. | Water repellent solution for wood and method |
US5984905A (en) | 1994-07-11 | 1999-11-16 | Southwest Research Institute | Non-irritating antimicrobial coating for medical implants and a process for preparing same |
HRP960015B1 (en) | 1995-02-01 | 2000-12-31 | Bayer Ag | Substituted indole derivatives |
DE19504386C2 (en) | 1995-02-10 | 1997-08-28 | Univ Dresden Tech | Process for the production of a graded coating from calcium phosphate phases and metal oxide phases on metallic implants |
US5753322A (en) | 1995-04-21 | 1998-05-19 | Ykk Corporation | Antibacterial, antifungal aluminum building materials and fixtures using the materials |
JP2795824B2 (en) | 1995-05-12 | 1998-09-10 | オオタ株式会社 | Surface treatment method for titanium-based implant and biocompatible titanium-based implant |
AU6423796A (en) | 1995-08-29 | 1997-03-06 | Johnson & Johnson Professional, Inc. | Bone prosthesis with protected coating for penetrating bone intergrowth |
JP3247308B2 (en) | 1996-12-05 | 2002-01-15 | 住友大阪セメント株式会社 | Light alloy excellent in antibacterial property and method for producing the same |
US5833463A (en) | 1996-12-09 | 1998-11-10 | Hurson; Steven M. | Titanium surface treated dental screw for attaching a prosthetic component to an implant |
JPH10168597A (en) | 1996-12-09 | 1998-06-23 | Mitsubishi Alum Co Ltd | Anodized aluminum material excellent in antibacterial property and its production |
JPH10168598A (en) | 1996-12-09 | 1998-06-23 | Mitsubishi Alum Co Ltd | Anodized aluminum material excellent in antibacterial property and its production |
SE513481C2 (en) | 1997-05-16 | 2000-09-18 | Nobel Biocare Ab | Implant element made of titanium with a titanium oxide surface modified by eloxidation |
WO1999001089A1 (en) | 1997-07-01 | 1999-01-14 | Brown University Research Foundation | Implantable prosthetic devices coated with bioactive molecules |
US6365220B1 (en) | 1997-11-03 | 2002-04-02 | Nucryst Pharmaceuticals Corp. | Process for production of actively sterile surfaces |
EP0972852B1 (en) | 1997-11-14 | 2005-04-06 | Sumitomo Osaka Cement Co., Ltd. | Method of producing antimicrobial metal articles and antimicrobial metal articles produced by the method |
JPH11140690A (en) | 1997-11-14 | 1999-05-25 | Kobe Steel Ltd | Aluminum material excellent in thermal cracking resistance and corrosion resistance |
US6267782B1 (en) | 1997-11-20 | 2001-07-31 | St. Jude Medical, Inc. | Medical article with adhered antimicrobial metal |
US6113636A (en) | 1997-11-20 | 2000-09-05 | St. Jude Medical, Inc. | Medical article with adhered antimicrobial metal |
JPH11181596A (en) | 1997-12-19 | 1999-07-06 | Nagoya Alumite Kk | Antibacterial anodic oxidation treated aluminum |
JPH11209895A (en) | 1998-01-26 | 1999-08-03 | Sumitomo Light Metal Ind Ltd | Metallic product excellent in antibacterial property and its production |
JPH11229186A (en) | 1998-02-19 | 1999-08-24 | Sumitomo Osaka Cement Co Ltd | Antibacterial corrosion-resistant light alloy and its production |
JPH11236699A (en) | 1998-02-23 | 1999-08-31 | Kobe Steel Ltd | Surface treated metallic material having excellent wear resistance and antimicrobial property and its production |
US6509057B2 (en) | 1998-04-01 | 2003-01-21 | Sumitomo Osaka Cement, Co., Ltd. | Antibacterial, antifungal or antialgal article and process for producing same |
JPH11302570A (en) | 1998-04-17 | 1999-11-02 | Nippon Alum Co Ltd | Production of antimicrobial coating film |
JP3902329B2 (en) | 1998-05-29 | 2007-04-04 | 株式会社神戸製鋼所 | Surface-treated metal material with durability, antibacterial properties, algae-proofing properties and anti-fouling properties |
EP1148830A1 (en) | 1999-02-04 | 2001-10-31 | Synthes Ag Chur | Bone screw |
WO2000051659A1 (en) | 1999-03-05 | 2000-09-08 | Matson Louis R | Surface-modified bioactive surgical implants suppressing tissue growth |
JP4457230B2 (en) | 1999-03-19 | 2010-04-28 | 明義 尾坂 | Surface treatment method for medical implant material |
US6582715B1 (en) | 1999-04-27 | 2003-06-24 | Agion Technologies, Inc. | Antimicrobial orthopedic implants |
SE514323C2 (en) * | 1999-05-31 | 2001-02-12 | Nobel Biocare Ab | Implants and procedure and use in implants |
DK1196150T3 (en) | 1999-06-14 | 2005-11-21 | Imp College Innovations Ltd | Solvent-containing sol-gel-derived bioglass compositions |
US6322588B1 (en) | 1999-08-17 | 2001-11-27 | St. Jude Medical, Inc. | Medical devices with metal/polymer composites |
US7048541B2 (en) | 2000-04-04 | 2006-05-23 | Nobel Biocare Ab | Implant having attachment and hole-insert parts, and method for producing such an implant |
US6719987B2 (en) | 2000-04-17 | 2004-04-13 | Nucryst Pharmaceuticals Corp. | Antimicrobial bioabsorbable materials |
AU2001288317A1 (en) | 2000-08-30 | 2002-03-13 | Agion Technologies, Llc | Bi-laminar, hyaluronan coatings with silver-based anti-microbial properties |
EP1207220B1 (en) | 2000-10-25 | 2008-01-16 | GHA Corporation | Method for surface treatment of aluminum or aluminum alloy |
DE20020649U1 (en) | 2000-12-06 | 2002-04-11 | Stryker Trauma Gmbh | Device for surgical or therapeutic use, in particular implants and surgical instruments and their accessories |
US7192445B2 (en) | 2000-12-06 | 2007-03-20 | Astra Tech Ab | Medical prosthetic devices and implants having improved biocompatibility |
US6913617B1 (en) | 2000-12-27 | 2005-07-05 | Advanced Cardiovascular Systems, Inc. | Method for creating a textured surface on an implantable medical device |
SE0101910D0 (en) * | 2001-05-29 | 2001-05-29 | Young Taeg Sul | Modified oxide |
SE519565C2 (en) | 2001-07-04 | 2003-03-11 | Nobel Biocare Ab | Arrangement and method of providing implant fixtures made primarily of titanium |
SE519531C2 (en) | 2001-07-04 | 2003-03-11 | Nobel Biocare Ab | Implants including pore arrangements coated with calcium phosphate |
SE519566C2 (en) | 2001-07-04 | 2003-03-11 | Nobel Biocare Ab | Method of Treating Implants by Coating with Calcium Phosphate and Bone Growth Stimulants |
US20030026848A1 (en) | 2001-07-06 | 2003-02-06 | Joshi Ashok V. | Beneficial materials for topical or internal use by a human or other animal |
US6749639B2 (en) | 2001-08-27 | 2004-06-15 | Mayo Foundation For Medical Education And Research | Coated prosthetic implant |
GB0126467D0 (en) | 2001-11-03 | 2002-01-02 | Accentus Plc | Deposition of coatings on substrates |
GB0208642D0 (en) | 2002-04-16 | 2002-05-22 | Accentus Plc | Metal implants |
GB0210786D0 (en) | 2002-05-10 | 2002-06-19 | Plasma Coatings Ltd | Orthopaedic and dental implants |
CA2489676A1 (en) | 2002-06-27 | 2004-01-08 | Marc Long | Prosthetic devices having diffusion-hardened surfaces and bioceramic coatings |
EP1542738A1 (en) * | 2002-09-16 | 2005-06-22 | Lynntech Coatings Ltd. | Anodically treated biocompatible implants |
US8066854B2 (en) | 2002-12-18 | 2011-11-29 | Metascape Llc | Antimicrobial coating methods |
DE10323597A1 (en) | 2003-05-19 | 2004-12-09 | Aesculap Ag & Co. Kg | Medical device, process for its manufacture and use |
US7029566B2 (en) | 2003-09-12 | 2006-04-18 | Chinese Petroleum Corporation | Process of forming HA/ZrO2 complex coating on Co—Cr—Mo alloy |
US7488343B2 (en) * | 2003-09-16 | 2009-02-10 | Boston Scientific Scimed, Inc. | Medical devices |
WO2005084577A1 (en) | 2004-03-04 | 2005-09-15 | Young-Taek Sul | Osseoinductive magnesium-titanate implant and method of manufacturing the same |
GB0405680D0 (en) | 2004-03-13 | 2004-04-21 | Accentus Plc | Metal implants |
JP2005287985A (en) | 2004-04-05 | 2005-10-20 | Gha:Kk | Inflammation/odor suppressing member, manufacturing method thereof, and prosthesis and cast using it |
CA2571853A1 (en) | 2004-06-25 | 2006-01-12 | University Of Nevada, Reno | Bioceramic coated apparatus and method of forming the same |
WO2006007730A1 (en) | 2004-07-21 | 2006-01-26 | The University Of British Columbia | Method of electrolytically depositing a pharmaceutical coating onto a conductive osteal implant |
US20060035039A1 (en) | 2004-08-12 | 2006-02-16 | 3M Innovative Properties Company | Silver-releasing articles and methods of manufacture |
ITTO20040854A1 (en) | 2004-12-02 | 2005-03-02 | Torino Politecnico | WORKING PROCEDURE FOR GLASS, CERAMIC AND GLASS SURFACES FOR THE IMPLEMENTATION OF IMPLANTABLE DEVICES WITH ANTIBACTERIAL ACTION |
US20060229715A1 (en) | 2005-03-29 | 2006-10-12 | Sdgi Holdings, Inc. | Implants incorporating nanotubes and methods for producing the same |
JP2006271860A (en) | 2005-03-30 | 2006-10-12 | Japan Lifeline Co Ltd | Medical device and its manufacturing method |
JP2009507995A (en) | 2005-07-28 | 2009-02-26 | インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション | Niobium oxide compositions, nanostructures, bioactive forms and uses thereof |
US20070092403A1 (en) | 2005-10-21 | 2007-04-26 | Alan Wirbisky | Compact apparatus, compositions and methods for purifying nucleic acids |
DE102006004653A1 (en) | 2006-01-31 | 2007-08-02 | Zipprich, Holger, Dipl.-Ing. | Production of a metal body having a surface with nanoscopic pores or a nanoscopic structure used as a dental implant comprises impinging a metal base body with a current in an electrolytic bath |
US8012338B2 (en) | 2006-02-10 | 2011-09-06 | Syracuse University | Method for preparing biomedical surfaces |
EP2026852B1 (en) | 2006-06-12 | 2011-01-12 | Accentus Medical plc | Metal implants |
GB0702577D0 (en) | 2007-02-09 | 2007-03-21 | Ucl Business Plc | An article and a method of surface treatment of an article |
KR100910064B1 (en) | 2007-06-11 | 2009-07-30 | 재단법인서울대학교산학협력재단 | Implant material with excellent antibacterial and biocompatible properties and Manufacturing method thereof |
US20090035722A1 (en) | 2007-08-01 | 2009-02-05 | Ganesan Balasundaram | Hydroxyapatite coated nanostructured titanium surfaces |
PL2198076T3 (en) | 2007-10-03 | 2016-09-30 | Method of manufacturing metal with biocidal properties | |
US8545559B2 (en) | 2007-10-05 | 2013-10-01 | Washington State University | Modified metal materials, surface modifications to improve cell interactions and antimicrobial properties, and methods for modifying metal surface properties |
WO2009085096A2 (en) | 2007-12-05 | 2009-07-09 | Semprus Biosciences Corporation | Non-leaching, non-fouling antimicrobial coatings |
DE102008008517B4 (en) | 2008-02-11 | 2014-12-31 | Stryker Trauma Gmbh | Antimicrobial finish of titanium and titanium alloys with silver |
US20090204213A1 (en) | 2008-02-13 | 2009-08-13 | Depuy Products, Inc. | Metallic implants |
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2004
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AU2005221862B2 (en) | 2010-03-18 |
DE602005002353D1 (en) | 2007-10-18 |
AU2005221862C1 (en) | 2010-10-07 |
WO2005087982A8 (en) | 2006-04-20 |
EP1725701A1 (en) | 2006-11-29 |
US9011665B2 (en) | 2015-04-21 |
CA2557029C (en) | 2012-01-03 |
DE602005002353T2 (en) | 2008-05-29 |
WO2005087982A1 (en) | 2005-09-22 |
ES2290888T3 (en) | 2008-02-16 |
JP4690386B2 (en) | 2011-06-01 |
KR20070018879A (en) | 2007-02-14 |
ATE372401T1 (en) | 2007-09-15 |
AU2005221862A1 (en) | 2005-09-22 |
US20070181221A1 (en) | 2007-08-09 |
GB0405680D0 (en) | 2004-04-21 |
JP2007529621A (en) | 2007-10-25 |
EP1725701B1 (en) | 2007-09-05 |
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