CA2570078C - Inhaler device that reduces the risk for miscounting a dosage - Google Patents
Inhaler device that reduces the risk for miscounting a dosage Download PDFInfo
- Publication number
- CA2570078C CA2570078C CA2570078A CA2570078A CA2570078C CA 2570078 C CA2570078 C CA 2570078C CA 2570078 A CA2570078 A CA 2570078A CA 2570078 A CA2570078 A CA 2570078A CA 2570078 C CA2570078 C CA 2570078C
- Authority
- CA
- Canada
- Prior art keywords
- inhaler
- position ensuring
- ensuring means
- actuator body
- canister assembly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
- G06M1/00—Design features of general application
- G06M1/02—Housing
- G06M1/026—Connecting or supporting parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/007—Mechanical counters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/007—Mechanical counters
- A61M15/0071—Mechanical counters having a display or indicator
- A61M15/0073—Mechanical counters having a display or indicator on a ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/007—Mechanical counters
- A61M15/0071—Mechanical counters having a display or indicator
- A61M15/0075—Mechanical counters having a display or indicator on a disc
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/0081—Locking means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/27—General characteristics of the apparatus preventing use
- A61M2205/276—General characteristics of the apparatus preventing use preventing unwanted use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
- A61M2205/6045—General characteristics of the apparatus with identification means having complementary physical shapes for indexing or registration purposes
Abstract
Inhaler device (10) comprising an actuator body (20) and an inhaler canister assembly (70), the inhaler canister assembly (70) is comprised of a canister (30) with a metering valve at a valve end and a dose counter unit (60) attached to a base end thereof. Further, the inhaler canister assembly (70) comprises first position ensuring means (110, 230), the actuator body comprises second position ensuring means (120,210), wherein the first and second position ensuring means being complementary mating means, and the first and second position ensuring means being so arranged that the inhaler device (10) cannot be fired, nor the counter unit (60) count unless the first and second position ensuring means are in a mating relationship. There is also provided an inhaler canister assembly (70) and an actuator body (20).
Description
Inhaler device that reduces the risk for miscounting a dosage The present invention relates to the art of inhaler devices, and in particular to an inhaler device that ensures that a canister assembly is correctly inserted into an actuator body.
Background of the Invention Many types of medicines are provided in fluid form, such as a solution or suspension of particles in a propellant or emulsion, and are adapted for oral inhalation by a patient. As one example, a canister might contain asthma medicine such as fluticasone propionate.
Inhaler devices are commonly used for delivery of a wide range of medicaments.
Such an inhaler device normally comprises an actuator body that holds a canister of medicament, the canister being actuated by compression to deliver a dose of medicament through a mouthpiece to a user.
Canisters for holding a suspension or solution of a pharmaceutical substance in a propellant under pressure are well known. One such known canister to be used in an inhalation device comprises a can coupled with a metering valve. The metering valve consists of a body comprising a chamber, a valve stem (which extends from a head of the body) and a metering chamber, selectively communicable by the valve stem to the atmosphere via an L-shaped conduit within the valve body. The valve stem is axially displaceable between a first, extended position in which the metering chamber, and hence the canister, is closed to the atmosphere (since the L-shaped conduit is disposed wholly outside the metering chamber), and a second, depressed position, in which the metering chamber is in open communication with the outlet provided by the L-shaped conduit in the valve stem and through which a metered dose of propellant containing pharmaceutical substance is delivered.
Inserted in the inhaler device, the valve stem is inserted into a stem receiving body, which is part of the actuator body. The patient presses down on the base of the canister, held in an inverted position in the actuator body, whereby the valve stem is forced against the stem receiving body in the inside of the actuator, and when the valve stem has been depressed sufficiently to open the metering channel, the inhaler will discharge a single dose. This is known as the firing of the inhaler device. This technology is well known and described in many parts of the prior art. For example in Respiratory Drug delivery, Ed Peter Byron, CRC
press, 1991, and in Lung Biology in Health and Disease, Vol 94, Inhalation Aerosols, AJ Hickey, Publisher Marcel Decker, 1996 and in Pharmaceutical Preformulation and Formulation, Ed Mark Gibson, Chapter 10, Inhalation Dosage Fauns, IHS Health Group, 2001.
It is important for the patient to be able to ascertain the level of medicament remaining in the canister. This requirement is met by the use of a dose counter unit either attached to or part of the inhaler device. It is obvious that this counter must be accurate in that over-counting results in medicament being left in the inhaler unnecessarily resulting in more repeat prescribing with their resultant costs and inconvenience to patient. It also means that in an emergency situation the patient may not use the inhaler in the belief that it is empty when it is not. Conversely, undercounting could result in the inhaler being empty of medicament before the patient has a replacement, which could be dangerous for the patient and reduce patient compliance.
Regulatory guidelines require the over and undercounting errors to be minimised.
An inhaler traditionally contains from 120 to 200 doses (shots) so any counter must be reliable, accurate and easy to read. There are many examples of dose counters in the prior art, some located near the valve region of the canister and some attached to the base end of the canister which due to the fact that the caniSter is in an inverted position in the inhaler mouthpiece means that the counter is on the top of the assembled inhaler and can be easily viewed.
In US 4817822 a counter attached to the base end of the canister forming an inhaler canister assembly, is disclosed. A problem with the counter disclosed in US 4817822 is that the counter actuation member is arranged in a non protected position, whereby it can be actuated by mistake or tampered with. Moreover, the inhaler canister assembly can be placed in the wrong orientation in the actuator body, whereby the inhaler device could be fired without actuating the counter.
In WO 02/067844 a counter attached to the base of the canister is disclosed where the counter actuator means extends along the whole periphery of the top edge of the actuator body. One problem with this design is that the counter actuation member could easily be tampered with.
Moreover counters attached to canisters containing different medicament could easily be interchanged between different actuators and made to operate Summary of the Invention The object of some embodiments of the invention is to provide a new inhaler device, inhaler canister assembly and actuator body, which overcome one or more drawbacks of the prior art.
According to one aspect of the present invention, there is provided an inhaler canister assembly comprised of a canister with a metering valve at a valve end and a dose counter unit attached to a base end thereof, the inhaler canister assembly forming an inhaler device when combined with an actuator body, wherein the inhaler canister assembly comprises first position ensuring means being complementary mating means to second position ensuring means of the actuator body, the first position ensuring means being at least one mating aperture, groove or slit in the inhaler canister assembly and the second position ensuring means being at least one protrusion from the actuator body and the first and second position ensuring means being so arranged that the inhaler device cannot be fired, nor the counter count unless the first and second position ensuring means are in a mating relationship.
According to another aspect of the present invention, there is provided an inhaler device comprising an actuator body and the inhaler canister assembly as described above.
According to still another aspect of the present invention, there is provided an actuator body forming an inhaler device when combined with an inhaler canister assembly, the inhaler canister assembly is comprised of a canister with a metering valve at a valve end and a dose counter unit attached to a base end thereof, wherein the actuator body comprises second position ensuring means being complementary mating means to first position ensuring means of the inhaler canister assembly, the first position ensuring means being at least one mating aperture, groove or slit in the inhaler canister assembly and the second position ensuring means being at least one protrusion from the actuator body and the first and second position ensuring means being so arranged that the inhaler device cannot be fired, nor the counter count unless the first and second position ensuring means are in a mating relationship.
One advantage with such a device is that there is a greatly reduced risk for miscounting when firing the device or tampering with the counter.
3a Brief Description of the Drawings The invention will be described in detail below with reference to the drawings, in which Fig. 1 shows a partially sectional perspective view of an embodiment of an inhaler device according to the present invention.
Fig. 2a shows a schematic front view of an inhaler device according to the present invention.
Fig. 2b shows a schematic cross-sectional view along the line a¨a of the inhaler device in fig. 2a.
Figs. 3a and 3b, show schematic views of the inhaler device of figs. 2a and 2b in a firing state.
Fig. 4a shows a schematic top view of the inhaler can assembly of fig. 2a.
Fig. 4b shows a schematic bottom view of the actuator body of fig. 2b.
Fig. 5a shows a schematic front view of an embodiment of the inhaler device according to the present invention.
Background of the Invention Many types of medicines are provided in fluid form, such as a solution or suspension of particles in a propellant or emulsion, and are adapted for oral inhalation by a patient. As one example, a canister might contain asthma medicine such as fluticasone propionate.
Inhaler devices are commonly used for delivery of a wide range of medicaments.
Such an inhaler device normally comprises an actuator body that holds a canister of medicament, the canister being actuated by compression to deliver a dose of medicament through a mouthpiece to a user.
Canisters for holding a suspension or solution of a pharmaceutical substance in a propellant under pressure are well known. One such known canister to be used in an inhalation device comprises a can coupled with a metering valve. The metering valve consists of a body comprising a chamber, a valve stem (which extends from a head of the body) and a metering chamber, selectively communicable by the valve stem to the atmosphere via an L-shaped conduit within the valve body. The valve stem is axially displaceable between a first, extended position in which the metering chamber, and hence the canister, is closed to the atmosphere (since the L-shaped conduit is disposed wholly outside the metering chamber), and a second, depressed position, in which the metering chamber is in open communication with the outlet provided by the L-shaped conduit in the valve stem and through which a metered dose of propellant containing pharmaceutical substance is delivered.
Inserted in the inhaler device, the valve stem is inserted into a stem receiving body, which is part of the actuator body. The patient presses down on the base of the canister, held in an inverted position in the actuator body, whereby the valve stem is forced against the stem receiving body in the inside of the actuator, and when the valve stem has been depressed sufficiently to open the metering channel, the inhaler will discharge a single dose. This is known as the firing of the inhaler device. This technology is well known and described in many parts of the prior art. For example in Respiratory Drug delivery, Ed Peter Byron, CRC
press, 1991, and in Lung Biology in Health and Disease, Vol 94, Inhalation Aerosols, AJ Hickey, Publisher Marcel Decker, 1996 and in Pharmaceutical Preformulation and Formulation, Ed Mark Gibson, Chapter 10, Inhalation Dosage Fauns, IHS Health Group, 2001.
It is important for the patient to be able to ascertain the level of medicament remaining in the canister. This requirement is met by the use of a dose counter unit either attached to or part of the inhaler device. It is obvious that this counter must be accurate in that over-counting results in medicament being left in the inhaler unnecessarily resulting in more repeat prescribing with their resultant costs and inconvenience to patient. It also means that in an emergency situation the patient may not use the inhaler in the belief that it is empty when it is not. Conversely, undercounting could result in the inhaler being empty of medicament before the patient has a replacement, which could be dangerous for the patient and reduce patient compliance.
Regulatory guidelines require the over and undercounting errors to be minimised.
An inhaler traditionally contains from 120 to 200 doses (shots) so any counter must be reliable, accurate and easy to read. There are many examples of dose counters in the prior art, some located near the valve region of the canister and some attached to the base end of the canister which due to the fact that the caniSter is in an inverted position in the inhaler mouthpiece means that the counter is on the top of the assembled inhaler and can be easily viewed.
In US 4817822 a counter attached to the base end of the canister forming an inhaler canister assembly, is disclosed. A problem with the counter disclosed in US 4817822 is that the counter actuation member is arranged in a non protected position, whereby it can be actuated by mistake or tampered with. Moreover, the inhaler canister assembly can be placed in the wrong orientation in the actuator body, whereby the inhaler device could be fired without actuating the counter.
In WO 02/067844 a counter attached to the base of the canister is disclosed where the counter actuator means extends along the whole periphery of the top edge of the actuator body. One problem with this design is that the counter actuation member could easily be tampered with.
Moreover counters attached to canisters containing different medicament could easily be interchanged between different actuators and made to operate Summary of the Invention The object of some embodiments of the invention is to provide a new inhaler device, inhaler canister assembly and actuator body, which overcome one or more drawbacks of the prior art.
According to one aspect of the present invention, there is provided an inhaler canister assembly comprised of a canister with a metering valve at a valve end and a dose counter unit attached to a base end thereof, the inhaler canister assembly forming an inhaler device when combined with an actuator body, wherein the inhaler canister assembly comprises first position ensuring means being complementary mating means to second position ensuring means of the actuator body, the first position ensuring means being at least one mating aperture, groove or slit in the inhaler canister assembly and the second position ensuring means being at least one protrusion from the actuator body and the first and second position ensuring means being so arranged that the inhaler device cannot be fired, nor the counter count unless the first and second position ensuring means are in a mating relationship.
According to another aspect of the present invention, there is provided an inhaler device comprising an actuator body and the inhaler canister assembly as described above.
According to still another aspect of the present invention, there is provided an actuator body forming an inhaler device when combined with an inhaler canister assembly, the inhaler canister assembly is comprised of a canister with a metering valve at a valve end and a dose counter unit attached to a base end thereof, wherein the actuator body comprises second position ensuring means being complementary mating means to first position ensuring means of the inhaler canister assembly, the first position ensuring means being at least one mating aperture, groove or slit in the inhaler canister assembly and the second position ensuring means being at least one protrusion from the actuator body and the first and second position ensuring means being so arranged that the inhaler device cannot be fired, nor the counter count unless the first and second position ensuring means are in a mating relationship.
One advantage with such a device is that there is a greatly reduced risk for miscounting when firing the device or tampering with the counter.
3a Brief Description of the Drawings The invention will be described in detail below with reference to the drawings, in which Fig. 1 shows a partially sectional perspective view of an embodiment of an inhaler device according to the present invention.
Fig. 2a shows a schematic front view of an inhaler device according to the present invention.
Fig. 2b shows a schematic cross-sectional view along the line a¨a of the inhaler device in fig. 2a.
Figs. 3a and 3b, show schematic views of the inhaler device of figs. 2a and 2b in a firing state.
Fig. 4a shows a schematic top view of the inhaler can assembly of fig. 2a.
Fig. 4b shows a schematic bottom view of the actuator body of fig. 2b.
Fig. 5a shows a schematic front view of an embodiment of the inhaler device according to the present invention.
Fig. 5b shows a schematic cross-sectional view along the line b¨b of the inhaler device in fig. 5a.
Fig. 6 shows a schematic cross-sectional view of the counter unit of fig. 1.
Detailed Description of Preferred Embodiments In Fig. 1 an inhalation device 10 according to one embodiment of the invention is shown. It comprises an actuator body 20, which encloses a canister 30 holding the medicament. The medicament is delivered to the user through a valve stem 40 connected to the top of the canister 30 (lower part of the canister in the figure due to the invert position of the canister in the inhalation device). The medicament is inhaled by the user through a mouthpiece 50 that is a part of the actuator body 20. The mouthpiece 50 is in connection with the valve stem 40 via a stem receiving body 45 for receiving the medicament to be delivered.
Furthermore a dose counter unit 60 is provided at the base end of the canister 30, i.e. in the opposite end to the valve stem 40. In the embodiments disclosed herein, the dose counter unit 60 is preferably permanently attached to the canister 30, in order to avoid that the counter unit 60 is removed from one canister 30 and attached on another canister 30 containing a different level of medicament. The canister 30 with the attached dose counter unit 60 is hereafter referred to as an inhaler can assembly 70. When a dose of medicament should be delivered to the user, the inhaler can assembly 70 is pressed downwards whereby the valve stem 40 is forced into a position where it delivers a dose of medicament, or by other words is fired.
This is in conformity with many inhalation devices according to the prior art and will not be described in more detail here.
The counting is related to the downward motion of the inhaler can assembly 70.
The dose counter unit 60 should increase the number of counted doses by one every time a dose has been delivered. The dose counter unit 60 can either count up from zero or count down from a predetermined maximum number. Since undercounting is not to recommend due to the risk that the user believes that there is medicament left in the canister 30 when it actually is empty, the counter unit 60 usually is affected to count one count when the inhaler can assembly 70 has been pressed down a distance slightly less than is needed for delivering the dose of medicament.
The dose counter unit 60 comprises a counter housing 80 and a counter mechanism 90 with a counter actuator 100 for actuating the counter mechanism 90. The housing 80 is, in a downwards directed surface thereof, provided with an aperture 110 that is adapted to receive a protrusion 120 from the top edge 130 of the actuator body 20 in a mating relationship.
Fig. 6 shows a schematic cross-sectional view of the counter unit of fig. 1.
Detailed Description of Preferred Embodiments In Fig. 1 an inhalation device 10 according to one embodiment of the invention is shown. It comprises an actuator body 20, which encloses a canister 30 holding the medicament. The medicament is delivered to the user through a valve stem 40 connected to the top of the canister 30 (lower part of the canister in the figure due to the invert position of the canister in the inhalation device). The medicament is inhaled by the user through a mouthpiece 50 that is a part of the actuator body 20. The mouthpiece 50 is in connection with the valve stem 40 via a stem receiving body 45 for receiving the medicament to be delivered.
Furthermore a dose counter unit 60 is provided at the base end of the canister 30, i.e. in the opposite end to the valve stem 40. In the embodiments disclosed herein, the dose counter unit 60 is preferably permanently attached to the canister 30, in order to avoid that the counter unit 60 is removed from one canister 30 and attached on another canister 30 containing a different level of medicament. The canister 30 with the attached dose counter unit 60 is hereafter referred to as an inhaler can assembly 70. When a dose of medicament should be delivered to the user, the inhaler can assembly 70 is pressed downwards whereby the valve stem 40 is forced into a position where it delivers a dose of medicament, or by other words is fired.
This is in conformity with many inhalation devices according to the prior art and will not be described in more detail here.
The counting is related to the downward motion of the inhaler can assembly 70.
The dose counter unit 60 should increase the number of counted doses by one every time a dose has been delivered. The dose counter unit 60 can either count up from zero or count down from a predetermined maximum number. Since undercounting is not to recommend due to the risk that the user believes that there is medicament left in the canister 30 when it actually is empty, the counter unit 60 usually is affected to count one count when the inhaler can assembly 70 has been pressed down a distance slightly less than is needed for delivering the dose of medicament.
The dose counter unit 60 comprises a counter housing 80 and a counter mechanism 90 with a counter actuator 100 for actuating the counter mechanism 90. The housing 80 is, in a downwards directed surface thereof, provided with an aperture 110 that is adapted to receive a protrusion 120 from the top edge 130 of the actuator body 20 in a mating relationship.
5 Generally speaking, the aperture 110 and the protrusion 120 can be referred to as first and second position ensuring means respectively, as they ensure that the inhaler canister assembly 70 is received in the correct position with respect to the actuator body 20.
In order to avoid that the inhaler device 10 is fired without the corresponding actuation of the dose counter unit 60, the top edge 130 of the actuator body including the protrusion 120, and the bottom surface 140 of the counter housing 80 are so formed that depression of the inhaler canister assembly 70 cannot be perfoilned unless the protrusion 120 and the aperture 110 are positioned in the correct mating position. Moreover, when the inhaler can assembly 70 is depressed in order to fire the inhaler device 10, the protrusion 120 extends through the aperture 110 into the counter housing 80 and engages the counter actuator 100, and hence actuates the counter mechanism 90.
Figs. 2a, 2b, 3a, 3b, 4a and 4b more clearly show the relationship between the protrusion 120 and the aperture 110 in the counter housing 60 of the inhaler can assembly 70.
As is shown in these figures, the inhaler device 10 has two states of operation: normal state and firing state.
In the norinal state that is shown in figs. 2a and 2b, the metering valve of the canister 30 is closed and the protrusion 120 is aligned with the aperture 110 but not affecting the counter actuator 100. In the shown example, the protrusion 120 extends a small distance into the aperture 110, but in other embodiments the protrusion 120 may be located completely outside the aperture 110, as long as the protrusion 120 must enter the aperture 110 in order for the inhaler device 10 to be fired and for actuating the dose counter unit 60. In the firing state that is shown in figs. 3a and 3b, the metering valve is depressed so that a metered dose of medicine is delivered to a user via the mouthpiece 50. In the firing state the protrusion 120 extends through the aperture 110 into the counter housing 80 and actuates the counter actuator.
As can be appreciated by figs. 2a and 2b, the inhaler canister assembly 70 must be placed in the correct position with respect to the actuator body 20 in order for the protrusion 120 to fit into the aperture 110. If the inhaler canister assembly 70 is placed in the wrong position, the protrusion 120 will abut against the bottom surface 140 of the counter housing 80, and the firing operation cannot be performed. Furthermore, as the protrusion 120 will not extend through the aperture 110 into the counter housing 80, the counter actuator 100 is not actuated.
In a general embodiment of the inhaler device 10 the inhaler canister assembly 70 comprises first position ensuring means 110, the actuator body 20 comprises second position ensuring means 120, wherein the first and second position ensuring means 110, 120 are complementary mating means, and the first and second position ensuring means 110, 120 are so arranged that the inhaler device 10 cannot be fired, nor the counter unit 60 be actuated unless the first and second position ensuring means 110, 120 are in a mating relationship. In the embodiments disclosed above, the protrusion 120 serves as the second position ensuring means, and it also serves to actuate the counter actuator 100 and thus the counter unit 60.
However, the actuation of the counter actuator 100 might be performed by alternative means separated from the position ensuring means, as long as the counter actuator 100 cannot be actuated unless the first and second position ensuring means are in mating relationship.
It should be appreciated that there might be more than one pair of mating position ensuring means, which all cooperate to ensure that the inhaler canister assembly and the actuator body are positioned in a correct relationship, of which pairs at least one pair is comprised of a protrusion 120 from the actuator body 20 and a mating aperture 110 in the counter housing 80, and which protrusion 120 actuates the counter linit 60 in the firing operation. Figs. 5a and 5b schematically shows an alternative embodiment of the inhaler device according to the present invention, wherein the protrusion 120 is provided at a lower level 200 than the main =
portion of the upper edge 130 of the actuator body 20. In this embodiment, the essentially vertical portions 210 of the upper edge 130 interacts with essentially vertical side portions 230 of the downwards extending sections 220 of the counter housing 80 in order to form a secondary pair of position ensuring means. In this embodiment the protrusion 120 is protected from accidental damage by the secondary pair of position ensuring means, as they e.g.
prevents the protrusion 120 from excessive angular forces that can be applied by a user on the counter housing and potentially break the protrusion , if the secondary position ensuring means were not present. If the protrusion is damaged/removed, then the device could be fired and the counter would not count; therefore the device would undercount i.e.
display that there were more doses remaining than there actually were, a dangerous situation.
By arranging the counter actuator 100 so that it is activated by the relatively small sized protrusion 120 that has to be inserted into a mating aperture 110, the risk for accidental actuation, as well as willful tampering is minimized, as it requires that a similar small sized object has to be introduced into the aperture 110.
In the disclosed embodiment, the protrusion 120 and the mating aperture 110 have a rectangular cross section, but it may be given any suitable shape. The protrusion 120 may farther be formed such that the aperture 110 or first position ensuring means takes the form of a grove or a slit in the counter housing 80. In one embodiment, the shape of the protrusion/aperture 110, 120 is used to identify e.g. the content or concentration contained in the canister 30 and actuator bodies 20 adapted for delivering specific medicines, respectively, in order to avoid that a inhaler canister assembly 70 is used with an improper actuator body 20.
= In the disclosed embodiments, the actuation of the inhaler device 10 is performed by a linear relative movement of the inhaler canister assembly 70 with respect to the actuator body 20.
However, the actuation could also be an angular relative movement, or a combination thereof, and the first and second position ensuring means thus being adapted to the path of the movement.
Fig. 6 shows a schematic cross sectional view of the inhaler canister assembly 70 of the inhaler device 10 in fig. 1, and the following description refers to both figures. For clarity reasons the parts of the counter mechanism are omitted in fig 4. The dose counter unit 60 comprises a protecting shield 150 that extends downwards from the counter unit 60 adjacent to the outer surface of the actuator body 20. The protecting shield 150 further ensures that that dose counter unit 60 cannot be actuated by mistake, as it is positioned adjacent to the aperture 110 and thus further obstructs access to the aperture 110. Moreover, during the firing operation, the shield 150 covers the protrusion 120 and the aperture 110 and thus protects them from being obstructed in their relative movement The inner surface of the protecting shield 150 further serves as a guide means for guiding the protrusion 120 into mating relationship with the aperture 110. Alternatively, the inner surface of the protecting shield 150 can be provided with guide means in the form of ridges or the like. The dose counter unit 60 further comprises guiding means between the aperture and. the outer surface of the canister 30 in the form of an inclined surface or ridge 160. Furthermore, the protecting shield provides a large surface which allows a clear label to be added to the front of the device (dose level, drug etc) because the counter is attached in the normal position for the drug label (around the base of the canister).
In order to avoid that the inhaler device 10 is fired without the corresponding actuation of the dose counter unit 60, the top edge 130 of the actuator body including the protrusion 120, and the bottom surface 140 of the counter housing 80 are so formed that depression of the inhaler canister assembly 70 cannot be perfoilned unless the protrusion 120 and the aperture 110 are positioned in the correct mating position. Moreover, when the inhaler can assembly 70 is depressed in order to fire the inhaler device 10, the protrusion 120 extends through the aperture 110 into the counter housing 80 and engages the counter actuator 100, and hence actuates the counter mechanism 90.
Figs. 2a, 2b, 3a, 3b, 4a and 4b more clearly show the relationship between the protrusion 120 and the aperture 110 in the counter housing 60 of the inhaler can assembly 70.
As is shown in these figures, the inhaler device 10 has two states of operation: normal state and firing state.
In the norinal state that is shown in figs. 2a and 2b, the metering valve of the canister 30 is closed and the protrusion 120 is aligned with the aperture 110 but not affecting the counter actuator 100. In the shown example, the protrusion 120 extends a small distance into the aperture 110, but in other embodiments the protrusion 120 may be located completely outside the aperture 110, as long as the protrusion 120 must enter the aperture 110 in order for the inhaler device 10 to be fired and for actuating the dose counter unit 60. In the firing state that is shown in figs. 3a and 3b, the metering valve is depressed so that a metered dose of medicine is delivered to a user via the mouthpiece 50. In the firing state the protrusion 120 extends through the aperture 110 into the counter housing 80 and actuates the counter actuator.
As can be appreciated by figs. 2a and 2b, the inhaler canister assembly 70 must be placed in the correct position with respect to the actuator body 20 in order for the protrusion 120 to fit into the aperture 110. If the inhaler canister assembly 70 is placed in the wrong position, the protrusion 120 will abut against the bottom surface 140 of the counter housing 80, and the firing operation cannot be performed. Furthermore, as the protrusion 120 will not extend through the aperture 110 into the counter housing 80, the counter actuator 100 is not actuated.
In a general embodiment of the inhaler device 10 the inhaler canister assembly 70 comprises first position ensuring means 110, the actuator body 20 comprises second position ensuring means 120, wherein the first and second position ensuring means 110, 120 are complementary mating means, and the first and second position ensuring means 110, 120 are so arranged that the inhaler device 10 cannot be fired, nor the counter unit 60 be actuated unless the first and second position ensuring means 110, 120 are in a mating relationship. In the embodiments disclosed above, the protrusion 120 serves as the second position ensuring means, and it also serves to actuate the counter actuator 100 and thus the counter unit 60.
However, the actuation of the counter actuator 100 might be performed by alternative means separated from the position ensuring means, as long as the counter actuator 100 cannot be actuated unless the first and second position ensuring means are in mating relationship.
It should be appreciated that there might be more than one pair of mating position ensuring means, which all cooperate to ensure that the inhaler canister assembly and the actuator body are positioned in a correct relationship, of which pairs at least one pair is comprised of a protrusion 120 from the actuator body 20 and a mating aperture 110 in the counter housing 80, and which protrusion 120 actuates the counter linit 60 in the firing operation. Figs. 5a and 5b schematically shows an alternative embodiment of the inhaler device according to the present invention, wherein the protrusion 120 is provided at a lower level 200 than the main =
portion of the upper edge 130 of the actuator body 20. In this embodiment, the essentially vertical portions 210 of the upper edge 130 interacts with essentially vertical side portions 230 of the downwards extending sections 220 of the counter housing 80 in order to form a secondary pair of position ensuring means. In this embodiment the protrusion 120 is protected from accidental damage by the secondary pair of position ensuring means, as they e.g.
prevents the protrusion 120 from excessive angular forces that can be applied by a user on the counter housing and potentially break the protrusion , if the secondary position ensuring means were not present. If the protrusion is damaged/removed, then the device could be fired and the counter would not count; therefore the device would undercount i.e.
display that there were more doses remaining than there actually were, a dangerous situation.
By arranging the counter actuator 100 so that it is activated by the relatively small sized protrusion 120 that has to be inserted into a mating aperture 110, the risk for accidental actuation, as well as willful tampering is minimized, as it requires that a similar small sized object has to be introduced into the aperture 110.
In the disclosed embodiment, the protrusion 120 and the mating aperture 110 have a rectangular cross section, but it may be given any suitable shape. The protrusion 120 may farther be formed such that the aperture 110 or first position ensuring means takes the form of a grove or a slit in the counter housing 80. In one embodiment, the shape of the protrusion/aperture 110, 120 is used to identify e.g. the content or concentration contained in the canister 30 and actuator bodies 20 adapted for delivering specific medicines, respectively, in order to avoid that a inhaler canister assembly 70 is used with an improper actuator body 20.
= In the disclosed embodiments, the actuation of the inhaler device 10 is performed by a linear relative movement of the inhaler canister assembly 70 with respect to the actuator body 20.
However, the actuation could also be an angular relative movement, or a combination thereof, and the first and second position ensuring means thus being adapted to the path of the movement.
Fig. 6 shows a schematic cross sectional view of the inhaler canister assembly 70 of the inhaler device 10 in fig. 1, and the following description refers to both figures. For clarity reasons the parts of the counter mechanism are omitted in fig 4. The dose counter unit 60 comprises a protecting shield 150 that extends downwards from the counter unit 60 adjacent to the outer surface of the actuator body 20. The protecting shield 150 further ensures that that dose counter unit 60 cannot be actuated by mistake, as it is positioned adjacent to the aperture 110 and thus further obstructs access to the aperture 110. Moreover, during the firing operation, the shield 150 covers the protrusion 120 and the aperture 110 and thus protects them from being obstructed in their relative movement The inner surface of the protecting shield 150 further serves as a guide means for guiding the protrusion 120 into mating relationship with the aperture 110. Alternatively, the inner surface of the protecting shield 150 can be provided with guide means in the form of ridges or the like. The dose counter unit 60 further comprises guiding means between the aperture and. the outer surface of the canister 30 in the form of an inclined surface or ridge 160. Furthermore, the protecting shield provides a large surface which allows a clear label to be added to the front of the device (dose level, drug etc) because the counter is attached in the normal position for the drug label (around the base of the canister).
Claims (10)
1. An inhaler canister assembly comprised of a canister with a metering valve at a valve end and a dose counter unit attached to a base end thereof, the inhaler canister assembly forming an inhaler device when combined with an actuator body, wherein the inhaler canister assembly comprises first position ensuring means being complementary mating means to second position ensuring means of the actuator body, the first position ensuring means being at least one mating aperture, groove or slit in the inhaler canister assembly and the second position ensuring means being at least one protrusion from the actuator body and the first and second position ensuring means being so arranged that the inhaler device cannot be fired, nor the counter count unless the first and second position ensuring means are in a mating relationship.
2. An inhaler device comprising an actuator body and the inhaler canister assembly according to claim 1.
3. The inhaler device according to claim 2 wherein the inhaler device is fired by a relative motion of the inhaler canister assembly with respect to the actuator body, and the first and second position ensuring means being arranged to prevent said relative motion of the inhaler canister assembly, when they are positioned in a non mating relationship.
4. The inhaler device according to claim 2 or 3 wherein the first position ensuring means is formed in the dose counter unit.
5. The inhaler device according to claim 4 wherein the second position ensuring means is arranged to act as actuation means for the dose counter.
6. The inhaler device according to claim 4 wherein, when the canister assembly is placed in the actuator body, the first and second position ensuring means are covered by a protecting shield that extends downwards from the counter adjacent to the outer surface of the actuator body.
7. The inhaler device according to claim 4 further comprising guiding means for guiding the second position ensuring means into mating relationship with the first position ensuring means.
8. The inhaler device according to claim 4 wherein guiding means are provided on the inner side of the protecting shield.
9. The inhaler device according to claim 4 wherein guiding means are provided between the first position ensuring means and the outer surface of the canister.
10. An actuator body forming an inhaler device when combined with an inhaler canister assembly, the inhaler canister assembly is comprised of a canister with a metering valve at a valve end and a dose counter unit attached to a base end thereof, wherein the actuator body comprises second position ensuring means being complementary mating means to first position ensuring means of the inhaler canister assembly, the first position ensuring means being at least one mating aperture, groove or slit in the inhaler canister assembly and the second position ensuring means being at least one protrusion from the actuator body and the first and second position ensuring means being so arranged that the inhaler device cannot be fired, nor the counter count unless the first and second position ensuring means are in a mating relationship.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0401786A SE0401786D0 (en) | 2004-07-05 | 2004-07-05 | Inhaler device |
| SE0401786-9 | 2004-07-05 | ||
| PCT/SE2005/000996 WO2006004498A1 (en) | 2004-07-05 | 2005-06-23 | Inhaler device that reduces the risk for miscounting a dosage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2570078A1 CA2570078A1 (en) | 2006-01-12 |
| CA2570078C true CA2570078C (en) | 2013-08-06 |
Family
ID=32768797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2570078A Active CA2570078C (en) | 2004-07-05 | 2005-06-23 | Inhaler device that reduces the risk for miscounting a dosage |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8528545B2 (en) |
| EP (1) | EP1765441B1 (en) |
| JP (2) | JP4959559B2 (en) |
| KR (1) | KR101247097B1 (en) |
| CN (2) | CN101035582A (en) |
| AR (1) | AR054295A1 (en) |
| AU (1) | AU2005260195C1 (en) |
| BR (1) | BRPI0512999B8 (en) |
| CA (1) | CA2570078C (en) |
| ES (1) | ES2679101T3 (en) |
| IL (1) | IL180099A (en) |
| MX (1) | MXPA06014658A (en) |
| NO (1) | NO20070520L (en) |
| NZ (1) | NZ552104A (en) |
| SE (1) | SE0401786D0 (en) |
| TR (1) | TR201809758T4 (en) |
| TW (1) | TW200613019A (en) |
| UY (1) | UY28998A1 (en) |
| WO (1) | WO2006004498A1 (en) |
| ZA (1) | ZA200610423B (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6082358A (en) | 1998-05-05 | 2000-07-04 | 1263152 Ontario Inc. | Indicating device for aerosol container |
| SE0401773D0 (en) * | 2004-07-02 | 2004-07-02 | Astrazeneca Ab | An inhalation and a method for assessing said inhalation device |
| SE0401786D0 (en) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Inhaler device |
| SE0401787D0 (en) * | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Inhaler device counter |
| GB0425518D0 (en) * | 2004-11-19 | 2004-12-22 | Clinical Designs Ltd | Substance source |
| GB0428204D0 (en) | 2004-12-23 | 2005-01-26 | Clinical Designs Ltd | Medicament container |
| RS52589B (en) * | 2005-08-24 | 2013-04-30 | Boehringer Ingelheim International Gmbh | Atomiser comprising a counter and an end of operation lock |
| GB0518400D0 (en) | 2005-09-09 | 2005-10-19 | Clinical Designs Ltd | Dispenser |
| GB0521510D0 (en) * | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
| DE102006032293A1 (en) | 2006-07-11 | 2008-01-24 | Friedrich Sanner Gmbh & Co. Kg | Device for the metered delivery of sprayable substances |
| JP4828403B2 (en) * | 2006-12-28 | 2011-11-30 | 株式会社吉野工業所 | Drug release device |
| GB0706405D0 (en) * | 2007-04-02 | 2007-05-09 | 3M Innovative Properties Co | Dose counter |
| WO2010075240A1 (en) * | 2008-12-22 | 2010-07-01 | Novartis Ag | Medical device |
| GB0904059D0 (en) | 2009-03-10 | 2009-04-22 | Euro Celtique Sa | Counter |
| GB0904040D0 (en) | 2009-03-10 | 2009-04-22 | Euro Celtique Sa | Counter |
| GB2469068B (en) * | 2009-03-31 | 2011-03-09 | Naseem Bari | Usage indicator |
| PL2684577T3 (en) * | 2009-05-18 | 2016-05-31 | Norton Healthcare Ltd | Dry-powder inhaler |
| WO2013045996A1 (en) | 2011-09-26 | 2013-04-04 | Trudell Medical International | Dose counter and medication delivery device |
| GB201118842D0 (en) * | 2011-11-01 | 2011-12-14 | Euro Celtique Sa | Dispenser cap arrangement |
| SG10201709354PA (en) * | 2014-05-07 | 2018-01-30 | Boehringer Ingelheim Int | Nebulizer, Indicator Device And Container |
| JP6559157B2 (en) * | 2014-05-07 | 2019-08-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Nebulizer |
| AU2018318123A1 (en) | 2017-08-15 | 2020-03-19 | Nephron Pharmaceuticals Corporation | Aqueous nebulization composition |
| CN110652632A (en) * | 2018-06-29 | 2020-01-07 | 上海英何医药包装技术有限公司 | Inhalation aerosol administration device |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3565070A (en) * | 1969-02-28 | 1971-02-23 | Riker Laboratories Inc | Inhalation actuable aerosol dispenser |
| US3900138A (en) * | 1972-08-07 | 1975-08-19 | Minnesota Mining & Mfg | Medicament dispenser |
| US4693551A (en) * | 1983-10-05 | 1987-09-15 | U.S. Holding Company, Inc. | Dielectric strength elements for loose tube optical fiber cable |
| DK481884D0 (en) * | 1984-10-09 | 1984-10-09 | Karl Holm | MEDICAL ORAL OR SWALLOW SPRAY APPLIANCES |
| GB8610121D0 (en) * | 1986-04-25 | 1986-05-29 | Glaxo Group Ltd | Medical aerosol devices |
| FI871799A (en) | 1986-04-25 | 1987-10-26 | Glaxo Group Ltd | INDIKERINGSANORDNING. |
| US5009338A (en) | 1989-02-03 | 1991-04-23 | Senetics Corporation | Indicator cap for a medicine bottle |
| US5718355A (en) * | 1989-02-03 | 1998-02-17 | Senetics, Inc. | Indicator device responsive to axial force for use with inhaler |
| DE69233258T2 (en) | 1991-08-26 | 2004-05-19 | Minnesota Mining And Mfg. Co., Saint Paul | powder dispenser |
| US5724957A (en) * | 1993-01-29 | 1998-03-10 | Aradigm Corporation | Intrapulmonary delivery of narcotics |
| US5505192A (en) * | 1993-11-12 | 1996-04-09 | New-Med Corporation | Dispenser monitoring system |
| US5411173A (en) * | 1993-12-17 | 1995-05-02 | Weinstein; Albert | Counter attachment for product dispensers |
| GB2288259A (en) | 1994-03-30 | 1995-10-11 | Norton Healthcare Ltd | Inhaler dose counter |
| US5564414A (en) | 1994-05-26 | 1996-10-15 | Walker; William F. | Pressurized and metered medication dose counter on removable sleeve |
| US5482030A (en) * | 1994-06-13 | 1996-01-09 | Klein; David | Aerosol and non-aerosol spray counter |
| US5544647A (en) | 1994-11-29 | 1996-08-13 | Iep Group, Inc. | Metered dose inhalator |
| GB2320489A (en) * | 1996-12-20 | 1998-06-24 | Norton Healthcare Ltd | Inhaler dose counter |
| US5904139A (en) * | 1997-03-28 | 1999-05-18 | Hauser; Stephen G. | Breath coordinated inhaler |
| JPH10267700A (en) | 1997-03-28 | 1998-10-09 | Nippon Seiki Co Ltd | Front side board for instrument, and its manufacture |
| US5871007A (en) * | 1997-06-09 | 1999-02-16 | Chase Marketing International L.L.C. | Throat spray counting mechanism |
| TW533865U (en) | 1997-06-10 | 2003-05-21 | Glaxo Group Ltd | Dispenser for dispensing medicament and actuation indicating device |
| EP1449557B1 (en) * | 1998-01-16 | 2016-09-07 | Trudell Medical International | Dispensing device kit |
| US6082358A (en) * | 1998-05-05 | 2000-07-04 | 1263152 Ontario Inc. | Indicating device for aerosol container |
| US6729330B2 (en) * | 1998-05-05 | 2004-05-04 | Trudell Medical International | Indicating device for aerosol container |
| US6257233B1 (en) * | 1998-06-04 | 2001-07-10 | Inhale Therapeutic Systems | Dry powder dispersing apparatus and methods for their use |
| US6615827B2 (en) * | 1999-09-08 | 2003-09-09 | Sapphire Designs, Inc. | Inhalation counter device |
| MXPA02003784A (en) | 1999-10-16 | 2002-12-13 | Glaxo Group Ltd | Device housing for an aerosol container. |
| SE515858C2 (en) | 1999-11-26 | 2001-10-22 | Ernst Hoerlins Ingenjoersbyra | Counter and spray dose inhaler with the counter |
| GB2360272B (en) | 2000-03-07 | 2002-02-13 | Bespak Plc | Improvements in or relating to valves for dispensers |
| GB2372542B (en) * | 2001-02-23 | 2003-08-20 | Bespak Plc | Dosage counting devices |
| FR2830527B1 (en) * | 2001-10-04 | 2004-08-27 | Valois Sa | DOSAGE COUNTER FOR A FLUID PRODUCT DISPENSER |
| EP1369139A1 (en) | 2002-06-03 | 2003-12-10 | 3M Innovative Properties Company | Dose indicators and dispensing canister-indicator assemblies |
| ATE424010T1 (en) * | 2002-06-21 | 2009-03-15 | Glaxo Group Ltd | ACTIVATION INDICATOR FOR A DISPENSING DEVICE |
| US7322352B2 (en) * | 2002-09-21 | 2008-01-29 | Aventis Pharma Limited | Inhaler |
| FR2846308B1 (en) * | 2002-10-28 | 2006-02-10 | Valois Sas | FLUID PRODUCT DISPENSING DEVICE WITH DOSE INDICATOR |
| WO2004041334A2 (en) | 2002-11-04 | 2004-05-21 | Bang & Olufsen Medicom A/S | Device for dispension |
| NL1021837C2 (en) * | 2002-11-05 | 2004-05-07 | Fountain Patents B V | Mold and method for the manufacture of containers such as tub-shaped containers. |
| US20040221840A1 (en) * | 2003-01-07 | 2004-11-11 | Stockman-Lamb Melissa Soyna | Inhaler |
| US6971381B2 (en) * | 2003-01-17 | 2005-12-06 | Stanley C. Langford | Actuation inhibitor for metered dose inhalers |
| SE525061C2 (en) | 2003-04-08 | 2004-11-23 | Ernst Hoerlins Ingenjoersbyraa | Counters for counting doses |
| GB0328502D0 (en) * | 2003-12-10 | 2004-01-14 | 3M Innovative Properties Co | Metered dose dispensers and assemblies therefor |
| SE0401773D0 (en) | 2004-07-02 | 2004-07-02 | Astrazeneca Ab | An inhalation and a method for assessing said inhalation device |
| SE0401786D0 (en) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Inhaler device |
| SE0401787D0 (en) * | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Inhaler device counter |
-
2004
- 2004-07-05 SE SE0401786A patent/SE0401786D0/en unknown
-
2005
- 2005-06-23 CN CNA2005800221427A patent/CN101035582A/en active Pending
- 2005-06-23 ES ES05754095.7T patent/ES2679101T3/en active Active
- 2005-06-23 CA CA2570078A patent/CA2570078C/en active Active
- 2005-06-23 JP JP2007520262A patent/JP4959559B2/en active Active
- 2005-06-23 TR TR2018/09758T patent/TR201809758T4/en unknown
- 2005-06-23 WO PCT/SE2005/000996 patent/WO2006004498A1/en active Application Filing
- 2005-06-23 KR KR1020077000207A patent/KR101247097B1/en active IP Right Grant
- 2005-06-23 JP JP2007520261A patent/JP4805923B2/en active Active
- 2005-06-23 US US11/571,645 patent/US8528545B2/en active Active
- 2005-06-23 MX MXPA06014658A patent/MXPA06014658A/en active IP Right Grant
- 2005-06-23 NZ NZ552104A patent/NZ552104A/en unknown
- 2005-06-23 AU AU2005260195A patent/AU2005260195C1/en active Active
- 2005-06-23 BR BRPI0512999A patent/BRPI0512999B8/en active IP Right Grant
- 2005-06-23 CN CN2011100212675A patent/CN102058921A/en active Pending
- 2005-06-23 EP EP05754095.7A patent/EP1765441B1/en active Active
- 2005-07-04 UY UY28998A patent/UY28998A1/en unknown
- 2005-07-05 AR ARP050102794A patent/AR054295A1/en unknown
- 2005-07-05 TW TW094122751A patent/TW200613019A/en unknown
-
2006
- 2006-12-12 ZA ZA2006/10423A patent/ZA200610423B/en unknown
- 2006-12-14 IL IL180099A patent/IL180099A/en active IP Right Grant
-
2007
- 2007-01-26 NO NO20070520A patent/NO20070520L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102058921A (en) | 2011-05-18 |
| TW200613019A (en) | 2006-05-01 |
| JP4805923B2 (en) | 2011-11-02 |
| US20080060643A1 (en) | 2008-03-13 |
| NO20070520L (en) | 2007-03-22 |
| CN101035582A (en) | 2007-09-12 |
| IL180099A0 (en) | 2007-05-15 |
| JP2008504925A (en) | 2008-02-21 |
| TR201809758T4 (en) | 2018-07-23 |
| AU2005260195A1 (en) | 2006-01-12 |
| JP4959559B2 (en) | 2012-06-27 |
| CA2570078A1 (en) | 2006-01-12 |
| AR054295A1 (en) | 2007-06-20 |
| AU2005260195B2 (en) | 2008-10-30 |
| ES2679101T3 (en) | 2018-08-22 |
| ZA200610423B (en) | 2008-01-08 |
| KR20070043771A (en) | 2007-04-25 |
| KR101247097B1 (en) | 2013-03-25 |
| NZ552104A (en) | 2009-12-24 |
| BRPI0512999A (en) | 2008-04-22 |
| IL180099A (en) | 2012-01-31 |
| WO2006004498A1 (en) | 2006-01-12 |
| US8528545B2 (en) | 2013-09-10 |
| EP1765441B1 (en) | 2018-05-16 |
| MXPA06014658A (en) | 2007-02-12 |
| AU2005260195C1 (en) | 2011-06-30 |
| BRPI0512999B8 (en) | 2021-06-22 |
| EP1765441A1 (en) | 2007-03-28 |
| UY28998A1 (en) | 2006-02-24 |
| BRPI0512999B1 (en) | 2017-07-11 |
| JP2008504924A (en) | 2008-02-21 |
| SE0401786D0 (en) | 2004-07-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2570078C (en) | Inhaler device that reduces the risk for miscounting a dosage | |
| CN110545868B (en) | Medicinal inhaler driving mechanism | |
| EP1768727B1 (en) | An inhalation device and a method for assembling said inhalation device | |
| JP4605388B2 (en) | Dosing device | |
| US20060254581A1 (en) | Dose counting in metered dose inhaler | |
| US9032953B2 (en) | Modular aerosol delivery system | |
| KR20140063784A (en) | Inhaler | |
| KR20030058937A (en) | Pre-metered dose magazine for breath-actuated dry powder inhaler | |
| JP2008100089A (en) | Indicating device used for dispensing device | |
| GB2429166A (en) | Inhaler counter |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |