CA2573787A1 - Method and apparatus for applying fluids to a biological sample - Google Patents

Method and apparatus for applying fluids to a biological sample Download PDF

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Publication number
CA2573787A1
CA2573787A1 CA002573787A CA2573787A CA2573787A1 CA 2573787 A1 CA2573787 A1 CA 2573787A1 CA 002573787 A CA002573787 A CA 002573787A CA 2573787 A CA2573787 A CA 2573787A CA 2573787 A1 CA2573787 A1 CA 2573787A1
Authority
CA
Canada
Prior art keywords
biological sample
cap
curved surface
curved
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002573787A
Other languages
French (fr)
Other versions
CA2573787C (en
Inventor
Charles D. Lemme
Kurt Reinhardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ventana Medical Systems Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2573787A1 publication Critical patent/CA2573787A1/en
Application granted granted Critical
Publication of CA2573787C publication Critical patent/CA2573787C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/112499—Automated chemical analysis with sample on test slide

Abstract

The invention is directed to a method of contacting a biological sample with a solution, comprising the steps of moving a curved surface wetted with the solution in proximity to the biological sample whereby the distance separating the wetted curved surface and the biological sample is sufficient to form a moving liquid meniscus layer between the two. The invention is also directed to an apparatus for contacting a biological sample suspected of containing a biomarker with a solution, comprising a platform for supporting a microscope slide having a biological sample thereon; a translating cap having a curved lower surface positioned above the platform, the curved lower surface being in proximity to a biological sample when in operation; means for moving the translating cap back and forth over the biological sample; and means for applying and removing liquid to and from the cap.

Claims (28)

1. A method of contacting a biological sample with a solution comprising the step of moving a curved surface wetted with a solution in proximity to said biological sample whereby the distance separating said wetted curved surface and said biological sample is sufficient to form a moving liquid meniscus layer between the two.
2. The method of claim 1 wherein said solution contains a conjugate biomolecule selected from the group consisting of an antibody, a RNA/DNA probe, or a chemical stain or a chemical used in detection.
3. The method of claim 1 wherein said biological sample is a tissue section, a cellular preparation, or an array of RNA/DNA, tissue, protein or peptide.
4. The method of claim 1 wherein said tissue contains a biomarker selected from the group consisting of an antigen, an epitope, a cellular protein, or a DNA/RNA
sequence.
5. The method of claim 1 wherein said curved surface is made from metal, plastic or ceramic.
6. The method of claim 1 wherein said curved surface is convex with respect to the microscope slide surface.
7. The method of claim 1 wherein said curved surface is moved in a rectilinear fashion substantially parallel to the microscope slide's upper surface and over the biological sample's surface.
8. The method of claim 1 wherein the distance separating said wetted curved surface and said biological sample is from about 10 microns to about 100microns.
9. An automated method of contacting a biological sample suspected of containing a biomarker with a solution, comprising the step of moving under computer control a curved surface wetted with said solution, said solution containing a conjugate biomolecule in proximity to said biological sample whereby the distance separating said wetted curved surface and said biological sample is sufficient to form a moving liquid meniscus layer between the two.
10. The method of claim 9 wherein said solution contains a conjugate biomolecule selected from the group consisting of an antibody, a RNA/DNA probe, or a chemical stain or a chemical used in detection.
11. The method of claim 9 wherein said biological sample is a tissue section, a cellular preparation, or an array of RNA/DNA, tissue, protein or peptide.
12. The method of claim 9 wherein said tissue contains a biomarker selected from the group consisting of an antigen, an epitope, a cellular protein, or a DNA/RNA
sequence.
13. The method of claim 9 wherein said curved surface is made from metal, plastic or ceramic.
14. The method of claim 9 wherein said curved surface is convex with respect to the microscope slide surface.
15. The method of claim 9 wherein said curved surface is moved in a rectilinear fashion substantially parallel to the microscope slide's upper surface and over the biological sample's surface.
16. The method of claim 9 wherein the distance separating said wetted curved surface and said biological sample is from about 10 microns to about 100microns.
17. Apparatus for contacting a biological sample suspected of containing a biomarker with a solution, comprising (a) a platform for supporting a microscope slide having said biological sample thereon;
(b) a translating cap having a curved lower surface positioned above said platform, said curved lower surface being in proximity to said biological sample when in operation;
(c) means for moving said translating cap back and forth over said biological sample; and (d) means for applying and removing liquid to and from said cap.
18. The apparatus of claim 17 wherein said platform is capable of heating a slide placed thereon.
19. The apparatus of claim 17 wherein said cap substantially covers the width of said microscope slide.
20. The apparatus of claim 17 wherein said cap is made of plastic or ceramic.
21. The apparatus of claim 17 wherein said cap has a curved lower surface capable of supporting a meniscus of liquid formed between said curved lower surface and the upper slide surface.
22. The apparatus of claim 17 wherein said curved lower surface has a radius of about 25 mm.
23. The apparatus of claim 17 wherein the lowest part of the meniscus-forming portion of said cap is from about 0.01 to about 0.10 mm above said slide surface.
24. The apparatus of claim 17 wherein said means for moving said translating cap back and forth comprises a rod connected to said cap at one end, and to a mechanism for imparting motion to said cap at the other.
25. The apparatus of claim 24 wherein said rod further comprises a vertically flexible member connected to said cap at a first end and to said rod at its second end.
26. The apparatus of claim 17 wherein said means for applying and removing liquid to and from said cap comprises a rinse pad being adapted to apply liquid to said cap when said cap is brought into close proximity to said rinse pad.
27. The apparatus of claim 17 wherein said means for applying liquid to said cap comprises a pipettor device for applying liquids to said cap.
28. Automatic apparatus for introducing a conjugate biomolecule into a biological sample suspected of containing a biomarker, comprising (a) a platform for supporting a microscope slide having a biological sample thereon;
(b) a translating cap having a curved lower surface positioned above said platform, said curved lower surface being in proximity to said biological sample when in operation;
(c) means for moving said translating cap back and forth over said biological sample;
(d) means for applying and removing liquid to and from said cap; and (e) means for electronically controlling all of the actions of said apparatus.
CA2573787A 2004-07-23 2005-07-21 Method and apparatus for applying fluids to a biological sample Active CA2573787C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59084304P 2004-07-23 2004-07-23
US60/590,843 2004-07-23
PCT/US2005/026014 WO2006012498A1 (en) 2004-07-23 2005-07-21 Method and apparatus for applying fluids to a biological sample

Publications (2)

Publication Number Publication Date
CA2573787A1 true CA2573787A1 (en) 2006-02-02
CA2573787C CA2573787C (en) 2010-11-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2573787A Active CA2573787C (en) 2004-07-23 2005-07-21 Method and apparatus for applying fluids to a biological sample

Country Status (8)

Country Link
US (1) US7820381B2 (en)
EP (1) EP1771730B1 (en)
JP (1) JP4806410B2 (en)
AU (1) AU2005267018B2 (en)
CA (1) CA2573787C (en)
DK (1) DK1771730T3 (en)
ES (1) ES2505253T3 (en)
WO (1) WO2006012498A1 (en)

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Also Published As

Publication number Publication date
US20060019302A1 (en) 2006-01-26
EP1771730A1 (en) 2007-04-11
US7820381B2 (en) 2010-10-26
EP1771730B1 (en) 2014-08-20
WO2006012498A1 (en) 2006-02-02
AU2005267018B2 (en) 2008-10-23
DK1771730T3 (en) 2014-09-08
JP4806410B2 (en) 2011-11-02
AU2005267018A1 (en) 2006-02-02
JP2008507701A (en) 2008-03-13
ES2505253T3 (en) 2014-10-09
CA2573787C (en) 2010-11-30

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