CA2599156A1 - Dosage form containing oxycodone and naloxone - Google Patents
Dosage form containing oxycodone and naloxone Download PDFInfo
- Publication number
- CA2599156A1 CA2599156A1 CA002599156A CA2599156A CA2599156A1 CA 2599156 A1 CA2599156 A1 CA 2599156A1 CA 002599156 A CA002599156 A CA 002599156A CA 2599156 A CA2599156 A CA 2599156A CA 2599156 A1 CA2599156 A1 CA 2599156A1
- Authority
- CA
- Canada
- Prior art keywords
- dosage form
- form according
- oxycodone
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
The present invention concerns a dosage form comprising oxycodone and naloxone which is characterized by specific in vivo parameters such as tmax, Cmax,AUCt value, mean bowel function score and/or duration of analgesic efficacy.
Claims (26)
1. A dosage form comprising oxycodone and/or a pharmaceutically acceptable salt thereof and naloxone and/or a pharmaceutically acceptable salt thereof, which provides a t max for oxycodone or a pharmaceutically acceptable salt at about 1 to about 17 hours, at about 2 to about 15 hours, at about 3 to about 8 hours or at about 4 to about 5 hours after single dose administration to healthy human subjects.
2. The dosage form according to claim 1, which provides an improvement of bowel function during pain therapy, in particular an improvement of the mean bowel function score of at least about 5, at least about 8, at least about 10 or at least about 15 after steady state administration to human patients, wherein the mean bowel function score is measured with a numerical analog scale ranging from 0 to 100.
3. The dosage form according to claim 1 or 2, which provides an analgesic effect for at least about 12 hours or at least about 24 hours after steady state administration to human patients or healthy human subjects.
4. The dosage form according to any of the preceding claims, which provides an AUCt value for oxycodone of about 100 ng.cndot.h/mL to about ng.cndot.h/mL, about 400 ng.cndot.h/mL to about 550 ng.cndot.h/mL, or about 450 to about 510 ng.cndot.h/mL after single dose administration to healthy human subjects.
5. The dosage form according to any of the preceding claims, which provides a C max for oxycodone of about 5 ng/mL to about 50 ng/mL, about ng/mL to about 40 ng/mL or about 35 ng/mL after single dose administration to healthy human subjects.
6. The dosage form according to any of the preceding claims, which in terms of efficacy is ranked good or very good by more than 50% of patients and preferably by more than 70% of patients.
7. The dosage form according to any of the preceding claims, which in terms of tolerability is ranked good or very good by more than 60% of patients and preferably by more than 70 or even 80% of patients.
8. The dosage form according to any of the preceding claims, which provides a reduction of days with laxative intake by at least 10%, preferably by at least 20%, more preferably by at least 25% and even more preferably by at least 30%.
9. The dosage form according to any of the preceding claims, which provides an improved side effect profile.
10. The dosage form according to any of the preceding claims, which shows no food effect.
11. The dosage form according to any of the preceding claims, which precipitates withdrawal symptoms in opioid dependent human subjects.
12. The dosage form according to any of the preceding claims, wherein oxycodone and/or naloxone are present in the form of a hydrochloride.
13. The dosage form according to any of the preceding claims, wherein oxycodone or a pharmaceutically acceptable salt thereof and naloxone or a pharmaceutically acceptable salt thereof are present in a weight ratio range of 2:1.
14. The dosage form according to any of the preceding claims, wherein naloxone or a pharmaceutically acceptable salt thereof is present in an amount of about 10 to about 40 mg, and preferably of about 20 mg and wherein oxycodone or a pharmaceutically acceptable salt thereof is present in an amount of about 10 to about 160 mg, and preferably of about 80 mg or of about 40 mg.
15. The dosage form according to any of the preceding claims, wherein oxycodone and/or naloxone are released from the preparation in a sustained, invariant and/or independent manner.
16. The dosage form according to any of the preceding claims, wherein the preparation comprises a non-swellable and non-erosive diffusion matrix.
17. The dosage form according to claim 16, wherein the diffusion matrix comprises at least one ethylcellulose component and at least one fatty alcohol.
18. The dosage form according to claim 17, wherein the fatty alcohol is selected from lauryl, myrestyl, stearyl, cetostearyl, ceryl and/or cetyl alcohol, and is preferably stearyl alcohol.
19. The dosage form according to claims 17 or 18, wherein the ethylcellulose component is a polymer mixture containing ethylcellulose.
20. The dosage form according to any of the preceding claims, wherein the dosage form has been formulated for oral, nasal, rectal application and/or for application by inhalation.
21. The dosage form according to any of the preceding claims, wherein the dosage form or precursors thereof are produced by extrusion.
22. The dosage form according to any of the preceding claims, which is suitable for stable storage over a period of at least 2 years under standard conditions (60% relative humidity, 25 C) in accordance with admission guidelines by the FDA or EMEA.
23. Use of any of the dosage forms according to claims 1 to 22 for the preparation of a pharmaceutical preparation for pain treatment.
24. Use according to claim 23 for the preparation of a pharmaceutical preparation for the treatment of pain and constipation during pain therapy.
25. Use according claims 23 or 24 for the preparation of a pharmaceutical preparation for the treatment of pain while preventing or reducing also abuse.
26. Use according to any of claims 23 to 25, wherein the dosage form is suitable for once-a-day or twice-a-day administration at steady state or of a single dose to human patients.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2768075A CA2768075A1 (en) | 2005-02-28 | 2006-02-28 | Dosage form containing oxycodone and naloxone |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05004377.7 | 2005-02-28 | ||
| EP05004377A EP1695700A1 (en) | 2005-02-28 | 2005-02-28 | Dosage form containing oxycodone and naloxone |
| PCT/EP2006/060341 WO2006089973A2 (en) | 2005-02-28 | 2006-02-28 | Dosage form containing oxycodone and naloxone |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2768075A Division CA2768075A1 (en) | 2005-02-28 | 2006-02-28 | Dosage form containing oxycodone and naloxone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2599156A1 true CA2599156A1 (en) | 2006-08-31 |
| CA2599156C CA2599156C (en) | 2012-05-01 |
Family
ID=34933990
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2599156A Active CA2599156C (en) | 2005-02-28 | 2006-02-28 | Dosage form containing oxycodone and naloxone |
| CA2960011A Abandoned CA2960011A1 (en) | 2005-02-28 | 2006-02-28 | Dosage form containing oxycodone and naloxone |
| CA2768075A Abandoned CA2768075A1 (en) | 2005-02-28 | 2006-02-28 | Dosage form containing oxycodone and naloxone |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2960011A Abandoned CA2960011A1 (en) | 2005-02-28 | 2006-02-28 | Dosage form containing oxycodone and naloxone |
| CA2768075A Abandoned CA2768075A1 (en) | 2005-02-28 | 2006-02-28 | Dosage form containing oxycodone and naloxone |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US20080145429A1 (en) |
| EP (5) | EP1695700A1 (en) |
| JP (2) | JP2008531650A (en) |
| KR (1) | KR20070107805A (en) |
| CN (2) | CN101128191A (en) |
| AT (1) | ATE517611T1 (en) |
| AU (2) | AU2006217870B2 (en) |
| BR (1) | BRPI0607975A2 (en) |
| CA (3) | CA2599156C (en) |
| CY (1) | CY1111967T1 (en) |
| DE (2) | DE202006020095U1 (en) |
| DK (2) | DK1855657T3 (en) |
| ES (1) | ES2370409T3 (en) |
| FI (1) | FI7750U1 (en) |
| HK (1) | HK1111604A1 (en) |
| HR (1) | HRP20110775T1 (en) |
| IL (2) | IL185514A0 (en) |
| ME (1) | ME01262B (en) |
| MX (1) | MX2007010494A (en) |
| NZ (1) | NZ588875A (en) |
| PL (1) | PL1855657T3 (en) |
| PT (1) | PT1855657E (en) |
| RS (1) | RS51984B (en) |
| RU (1) | RU2428985C2 (en) |
| SI (1) | SI1855657T1 (en) |
| UA (1) | UA93543C2 (en) |
| WO (1) | WO2006089973A2 (en) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
| RU2241458C2 (en) | 1997-12-22 | 2004-12-10 | Эро-Селтик, С.А. | Combinations of agonist/antagonist for opioid |
| CN1525851A (en) | 2001-05-11 | 2004-09-01 | ������ҩ������˾ | Abuse-resistant controlled-release opioid dosage form |
| US7056500B2 (en) | 2001-10-18 | 2006-06-06 | Nektar Therapeutics Al, Corporation | Polymer conjugates of opioid antagonists |
| ES2546010T3 (en) | 2002-04-05 | 2015-09-17 | Euro-Celtique S.A. | Pharmaceutical preparation containing oxycodone and naloxone |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE10361596A1 (en) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Process for producing an anti-abuse dosage form |
| DE102005005446A1 (en) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Break-resistant dosage forms with sustained release |
| DE10336400A1 (en) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Anti-abuse dosage form |
| EP1604667A1 (en) * | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the restless leg syndrome |
| EP1604666A1 (en) | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD) |
| DE102004032049A1 (en) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Anti-abuse, oral dosage form |
| CA2594373A1 (en) * | 2005-01-28 | 2006-08-03 | Euro-Celtique S.A. | Alcohol resistant dosage forms |
| DE102005005449A1 (en) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Process for producing an anti-abuse dosage form |
| EP1702558A1 (en) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Method and device for the assessment of bowel function |
| EP1695700A1 (en) | 2005-02-28 | 2006-08-30 | Euro-Celtique S.A. | Dosage form containing oxycodone and naloxone |
| DE202006018609U1 (en) * | 2006-08-29 | 2007-05-16 | Euro-Celtique S.A. | Needle-free apparatus for administrating pharmaceutical composition in humans, comprises a housing; auxiliary substance to force a pharmaceutical composition from a package into human body; a composition comprising analgesic, e.g. opioids |
| MX2009004965A (en) * | 2006-11-07 | 2009-06-05 | Nektar Therapeutics Al Corp | Dosage forms and co-administration of an opioid agonist and an opioid antagonist. |
| US20090004231A1 (en) | 2007-06-30 | 2009-01-01 | Popp Shane M | Pharmaceutical dosage forms fabricated with nanomaterials for quality monitoring |
| EP2042176A1 (en) * | 2007-09-26 | 2009-04-01 | Euro-Celtique S.A. | Use of a combination of an opioid agonist and an opioid antagonist for the treatment of Crohn's disease |
| JP5651818B2 (en) | 2007-12-17 | 2015-01-14 | パラディン ラブス インコーポレーテッド | Controlled release formulation to prevent misuse |
| EP2249811A1 (en) | 2008-01-25 | 2010-11-17 | Grünenthal GmbH | Pharmaceutical dosage form |
| HUE030803T2 (en) | 2008-05-09 | 2017-06-28 | Gruenenthal Gmbh | Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step |
| ES2635733T3 (en) * | 2008-07-07 | 2017-10-04 | Euro-Celtique S.A. | Use of opioid antagonists to treat urinary retention |
| US8486449B2 (en) | 2008-12-16 | 2013-07-16 | Paladin Labs Inc. | Misuse preventative, controlled release formulation |
| SG174286A1 (en) | 2009-03-10 | 2011-10-28 | Euro Celtique Sa | Immediate release pharmaceutical compositions comprising oxycodone and naloxone |
| EP2456427B1 (en) | 2009-07-22 | 2015-03-04 | Grünenthal GmbH | Hot-melt extruded controlled release dosage form |
| PE20120572A1 (en) | 2009-07-22 | 2012-06-06 | Gruenenthal Chemie | HANDLING RESISTANT STABILIZED OXIDATION DOSAGE FORM |
| US8475832B2 (en) | 2009-08-07 | 2013-07-02 | Rb Pharmaceuticals Limited | Sublingual and buccal film compositions |
| EP2531176B1 (en) | 2010-02-03 | 2016-09-07 | Grünenthal GmbH | Preparation of a powdery pharmaceutical composition by means of an extruder |
| AU2011252040C1 (en) | 2010-05-10 | 2015-04-02 | Euro-Celtique S.A. | Manufacturing of active-free granules and tablets comprising the same |
| CH705273B1 (en) | 2010-05-10 | 2016-06-15 | Euro Celtique Sa | Pharmaceutical composition - comprising hydromorphone and naloxone. |
| CA2798885C (en) | 2010-05-10 | 2014-11-18 | Euro-Celtique S.A. | Combination of active loaded granules with additional actives |
| CH705678B1 (en) * | 2010-08-13 | 2016-03-15 | Euro Celtique Sa | Use of binders for the production of storage-stable formulations. |
| PE20131126A1 (en) | 2010-09-02 | 2013-10-21 | Gruenenthal Chemie | ALTERATION RESISTANT DOSAGE FORM INCLUDING AN ANIONIC POLYMER |
| NZ607392A (en) | 2010-09-02 | 2015-03-27 | Gruenenthal Chemie | Tamper resistant dosage form comprising inorganic salt |
| CN103347495B (en) * | 2010-12-28 | 2017-06-20 | 欧洲凯尔特公司 | Treat the opioid agonist of Parkinson's and the combination of opioid antagonists |
| EP2736495B1 (en) | 2011-07-29 | 2017-08-23 | Grünenthal GmbH | Tamper-resistant tablet providing immediate drug release |
| DK2736497T3 (en) | 2011-07-29 | 2017-11-13 | Gruenenthal Gmbh | Shock-resistant tablet that provides an immediate release of a drug. |
| MX356421B (en) | 2012-02-28 | 2018-05-29 | Gruenenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer. |
| CN110101702A (en) | 2012-04-17 | 2019-08-09 | 普渡制药公司 | System and method for treating bad pharmacodynamics response caused by opioid |
| LT2838512T (en) | 2012-04-18 | 2018-11-12 | GrĆ¼nenthal GmbH | Tamper resistant and dose-dumping resistant pharmaceutical dosage form |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| US10154966B2 (en) | 2013-05-29 | 2018-12-18 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
| MX2015016254A (en) | 2013-05-29 | 2016-04-20 | Gruenenthal Gmbh | Tamper resistant dosage form with bimodal release profile. |
| KR20160031526A (en) | 2013-07-12 | 2016-03-22 | 그뤼넨탈 게엠베하 | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
| NZ716267A (en) | 2013-07-23 | 2017-05-26 | Euro Celtique Sa | A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation |
| CN105916505A (en) | 2013-11-13 | 2016-08-31 | 欧洲凯尔特公司 | Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome |
| CA2931553C (en) | 2013-11-26 | 2022-01-18 | Grunenthal Gmbh | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
| WO2015095644A1 (en) | 2013-12-20 | 2015-06-25 | AntiOP, Inc. | Intranasal naloxone compositions and methods of making and using same |
| US9480644B2 (en) | 2014-03-14 | 2016-11-01 | Opiant Pharmaceuticals, Inc. | Nasal drug products and methods of their use |
| US10085937B2 (en) | 2014-03-14 | 2018-10-02 | Adapt Pharma Limited | Nasal drug products and methods of their use |
| US9561177B2 (en) | 2014-03-14 | 2017-02-07 | Adapt Pharma Limited | Nasal drug products and methods of their use |
| RU2020112530A (en) | 2014-03-14 | 2021-07-21 | ОПИАНТ ФАРМАСЮТИКАЛС, Инк. | Nasal ready-to-use dosage forms and methods of their application |
| EP3142646A1 (en) | 2014-05-12 | 2017-03-22 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
| US9872835B2 (en) | 2014-05-26 | 2018-01-23 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping |
| EP3174534A1 (en) * | 2014-08-01 | 2017-06-07 | KRKA, d.d., Novo mesto | Pharmaceutical formulation comprising an opioid agonist and an opioid antagonist prepared by melt granulation using lipid esters |
| US9849124B2 (en) | 2014-10-17 | 2017-12-26 | Purdue Pharma L.P. | Systems and methods for treating an opioid-induced adverse pharmacodynamic response |
| US20160256453A1 (en) * | 2015-03-06 | 2016-09-08 | Develco Pharma Schweiz Ag | Opioid receptor antagonist for use in treating patients with severe constipation induced by high opiate dosage regimen |
| US20160256451A1 (en) * | 2015-03-06 | 2016-09-08 | Develco Pharma Schweiz Ag | Dosage of naloxone |
| WO2016170097A1 (en) | 2015-04-24 | 2016-10-27 | Grünenthal GmbH | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
| WO2016193456A2 (en) * | 2015-06-03 | 2016-12-08 | Develco Pharma Schweiz Ag | Opioid receptor antagonist for use in treating patients with severe constipation |
| WO2017042325A1 (en) | 2015-09-10 | 2017-03-16 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
| US9943513B1 (en) | 2015-10-07 | 2018-04-17 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
| US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
| US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
| US20210043293A1 (en) * | 2019-08-05 | 2021-02-11 | RxAssurance Corporation (d/b/a OpiSafe) | Techniques for providing interactive clinical decision support for drug dosage reduction |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3173876A (en) * | 1960-05-27 | 1965-03-16 | John C Zobrist | Cleaning methods and compositions |
| NL271831A (en) * | 1960-11-29 | |||
| US3276586A (en) * | 1963-08-30 | 1966-10-04 | Rosaen Filter Co | Indicating means for fluid filters |
| NL6714885A (en) * | 1967-11-02 | 1969-05-06 | ||
| US3541006A (en) * | 1968-07-03 | 1970-11-17 | Amicon Corp | Ultrafiltration process |
| US3773955A (en) * | 1970-08-03 | 1973-11-20 | Bristol Myers Co | Analgetic compositions |
| FR2183546B1 (en) * | 1972-05-10 | 1975-06-20 | Servier Lab | |
| US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US3916889A (en) * | 1973-09-28 | 1975-11-04 | Sandoz Ag | Patient ventilator apparatus |
| US3966940A (en) * | 1973-11-09 | 1976-06-29 | Bristol-Myers Company | Analgetic compositions |
| GB1478759A (en) * | 1974-11-18 | 1977-07-06 | Alza Corp | Process for forming outlet passageways in pills using a laser |
| US3966040A (en) * | 1975-03-05 | 1976-06-29 | Hazelwood John E | Combined vibratory feeder drive unit, vibratory feeder bowl, and parts separator |
| US4077407A (en) * | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
| US4126684A (en) * | 1976-02-11 | 1978-11-21 | Ciba-Geigy Corporation | 4-amino-3-p-halophenylbutyric acids and their derivatives used in the control of narcotic abuse |
| US4063064A (en) * | 1976-02-23 | 1977-12-13 | Coherent Radiation | Apparatus for tracking moving workpiece by a laser beam |
| US4285987A (en) * | 1978-10-23 | 1981-08-25 | Alza Corporation | Process for manufacturing device with dispersion zone |
| US4200098A (en) * | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
| US4457933A (en) | 1980-01-24 | 1984-07-03 | Bristol-Myers Company | Prevention of analgesic abuse |
| GB8332556D0 (en) * | 1983-12-06 | 1984-01-11 | Reckitt & Colmann Prod Ltd | Analgesic compositions |
| US4668685A (en) * | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| US4861598A (en) * | 1986-07-18 | 1989-08-29 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
| DE3812567A1 (en) * | 1988-04-15 | 1989-10-26 | Basf Ag | METHOD FOR PRODUCING PHARMACEUTICAL MIXTURES |
| EP0352361A1 (en) | 1988-07-29 | 1990-01-31 | The Rockefeller University | Method of treating patients suffering from chronic pain or chronic cough |
| US5236714A (en) * | 1988-11-01 | 1993-08-17 | Alza Corporation | Abusable substance dosage form having reduced abuse potential |
| US5656295A (en) * | 1991-11-27 | 1997-08-12 | Euro-Celtique, S.A. | Controlled release oxycodone compositions |
| US5266331A (en) * | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
| US5286493A (en) * | 1992-01-27 | 1994-02-15 | Euroceltique, S.A. | Stabilized controlled release formulations having acrylic polymer coating |
| US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
| US5273760A (en) * | 1991-12-24 | 1993-12-28 | Euroceltigue, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5681585A (en) * | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| US5472712A (en) * | 1991-12-24 | 1995-12-05 | Euroceltique, S.A. | Controlled-release formulations coated with aqueous dispersions of ethylcellulose |
| US5324351A (en) * | 1992-08-13 | 1994-06-28 | Euroceltique | Aqueous dispersions of zein and preparation thereof |
| IL119660A (en) * | 1993-05-10 | 2002-09-12 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
| IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
| DE4325465B4 (en) * | 1993-07-29 | 2004-03-04 | Zenz, Michael, Prof. Dr.med. | Oral pharmaceutical preparation for pain therapy |
| US5411745A (en) * | 1994-05-25 | 1995-05-02 | Euro-Celtique, S.A. | Powder-layered morphine sulfate formulations |
| US5866154A (en) * | 1994-10-07 | 1999-02-02 | The Dupont Merck Pharmaceutical Company | Stabilized naloxone formulations |
| US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
| US5865161A (en) * | 1995-01-04 | 1999-02-02 | Bruce; Norman R. | Baseball pitching device |
| US20020006964A1 (en) * | 1995-05-16 | 2002-01-17 | Young James W. | Methods of using and compositions comprising (+) sibutramine optionally in combination with other pharmacologically active compounds |
| DE19651551C2 (en) * | 1996-12-11 | 2000-02-03 | Klinge Co Chem Pharm Fab | Opioid antagonist-containing galenic formulation |
| US6207142B1 (en) * | 1997-04-14 | 2001-03-27 | Janssen Pharmaceutica N.V. | Compositions containing an antifungal and a cationic agent |
| PT1009387E (en) * | 1997-07-02 | 2006-08-31 | Euro Celtique Sa | STABILIZED CONTROLLED FREQUENCY FORMULATIONS OF TRAMADOL |
| RU2241458C2 (en) * | 1997-12-22 | 2004-12-10 | Эро-Селтик, С.А. | Combinations of agonist/antagonist for opioid |
| CN1204890C (en) * | 1997-12-22 | 2005-06-08 | 欧罗赛铁克股份有限公司 | Method for preventing abuse of opioid dosage forms |
| HUP0101954A3 (en) * | 1998-03-27 | 2002-09-30 | Upjohn Co | Use of cabergoline in the production of pharmaceutical compositions for the treatment of restless legs syndrome |
| US20030178031A1 (en) * | 1999-05-07 | 2003-09-25 | Du Pen, Inc. | Method for cancer pain treatment |
| DE60040536D1 (en) * | 1999-06-11 | 2008-11-27 | Telstra Corp Ltd | PROCESS FOR DEVELOPING AN INTERACTIVE SYSTEM |
| US20030118641A1 (en) * | 2000-07-27 | 2003-06-26 | Roxane Laboratories, Inc. | Abuse-resistant sustained-release opioid formulation |
| DE19938823A1 (en) * | 1999-08-19 | 2001-02-22 | Boehringer Ingelheim Pharma | Treatment of restless leg syndrome symptoms, using synergistic combination of alpha-2 agonist, preferably clonidine, and another neuro-psychic drug, e.g. pramipexol |
| US6258042B1 (en) * | 1999-09-17 | 2001-07-10 | James S. Factor | Visual analog scale and method of use for the diagnosis and/or treatment of physical pain |
| JP2003522144A (en) * | 2000-02-08 | 2003-07-22 | ユーロ−セルティーク，エス．エイ． | Controlled release compositions comprising opioid agonists and antagonists |
| US6716449B2 (en) * | 2000-02-08 | 2004-04-06 | Euro-Celtique S.A. | Controlled-release compositions containing opioid agonist and antagonist |
| US7223421B2 (en) * | 2000-06-30 | 2007-05-29 | Mcneil-Ppc, Inc. | Teste masked pharmaceutical particles |
| AR031152A1 (en) * | 2000-10-31 | 2003-09-10 | Upjohn Co | NEW TREATMENTS FOR THE CONCERNED LEG SYNDROME |
| AP2002002521A0 (en) * | 2001-04-19 | 2002-06-30 | Warner Lambert Co | Fused bicyclic or tricyclic amino acids. |
| UA81224C2 (en) * | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Dosage form of oxycodone and use thereof |
| CN1525851A (en) * | 2001-05-11 | 2004-09-01 | ������ҩ������˾ | Abuse-resistant controlled-release opioid dosage form |
| US20030004177A1 (en) * | 2001-05-11 | 2003-01-02 | Endo Pharmaceuticals, Inc. | Abuse-resistant opioid dosage form |
| SI1416842T1 (en) * | 2001-07-18 | 2009-06-30 | Euro Celtique Sa | Pharmaceutical combinations of oxycodone and naloxone |
| US20030044458A1 (en) * | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
| US7332182B2 (en) * | 2001-08-06 | 2008-02-19 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant |
| US20030092759A1 (en) * | 2001-09-24 | 2003-05-15 | Abuzzahab Faruk S. | Anticonvulsant derivatives useful for the treatment of restless limb syndrome and periodic limb movement disorder |
| SI1482835T1 (en) | 2002-03-06 | 2013-02-28 | Euro-Celtique S.A. | Analog scale for measuring pain |
| ES2546010T3 (en) * | 2002-04-05 | 2015-09-17 | Euro-Celtique S.A. | Pharmaceutical preparation containing oxycodone and naloxone |
| US20030191147A1 (en) * | 2002-04-09 | 2003-10-09 | Barry Sherman | Opioid antagonist compositions and dosage forms |
| WO2004004693A1 (en) * | 2002-07-05 | 2004-01-15 | Collgegium Pharmaceutical | Abuse-deterrent pharmaceutical compositions of opiods and other drugs |
| MY135852A (en) * | 2003-04-21 | 2008-07-31 | Euro Celtique Sa | Pharmaceutical products |
| US7700626B2 (en) * | 2004-06-04 | 2010-04-20 | Adolor Corporation | Compositions containing opioid antagonists |
| EP1604666A1 (en) * | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD) |
| EP1695700A1 (en) * | 2005-02-28 | 2006-08-30 | Euro-Celtique S.A. | Dosage form containing oxycodone and naloxone |
-
2005
- 2005-02-28 EP EP05004377A patent/EP1695700A1/en not_active Withdrawn
-
2006
- 2006-02-28 CA CA2599156A patent/CA2599156C/en active Active
- 2006-02-28 PL PL06708567T patent/PL1855657T3/en unknown
- 2006-02-28 ME MEP-2011-173A patent/ME01262B/en unknown
- 2006-02-28 SI SI200631121T patent/SI1855657T1/en unknown
- 2006-02-28 CA CA2960011A patent/CA2960011A1/en not_active Abandoned
- 2006-02-28 CA CA2768075A patent/CA2768075A1/en not_active Abandoned
- 2006-02-28 KR KR1020077022380A patent/KR20070107805A/en active Search and Examination
- 2006-02-28 AT AT06708567T patent/ATE517611T1/en active
- 2006-02-28 UA UAA200811581A patent/UA93543C2/en unknown
- 2006-02-28 JP JP2007557493A patent/JP2008531650A/en not_active Withdrawn
- 2006-02-28 DE DE202006020095U patent/DE202006020095U1/en not_active Expired - Lifetime
- 2006-02-28 EP EP15180143.8A patent/EP2962686B1/en not_active Revoked
- 2006-02-28 EP EP19167974.5A patent/EP3578173B1/en active Active
- 2006-02-28 CN CNA2006800059691A patent/CN101128191A/en not_active Withdrawn
- 2006-02-28 BR BRPI0607975-0A patent/BRPI0607975A2/en not_active Application Discontinuation
- 2006-02-28 EP EP10176716A patent/EP2258353A3/en not_active Withdrawn
- 2006-02-28 WO PCT/EP2006/060341 patent/WO2006089973A2/en active Application Filing
- 2006-02-28 CN CN201410239260.4A patent/CN104027297A/en active Pending
- 2006-02-28 RS RS20110458A patent/RS51984B/en unknown
- 2006-02-28 DE DE19167974.5T patent/DE19167974T1/en active Pending
- 2006-02-28 NZ NZ588875A patent/NZ588875A/en unknown
- 2006-02-28 AU AU2006217870A patent/AU2006217870B2/en active Active
- 2006-02-28 MX MX2007010494A patent/MX2007010494A/en active IP Right Grant
- 2006-02-28 ES ES06708567T patent/ES2370409T3/en active Active
- 2006-02-28 DK DK06708567.0T patent/DK1855657T3/en active
- 2006-02-28 US US11/885,288 patent/US20080145429A1/en not_active Abandoned
- 2006-02-28 PT PT06708567T patent/PT1855657E/en unknown
- 2006-02-28 RU RU2007135991/15A patent/RU2428985C2/en not_active IP Right Cessation
- 2006-02-28 EP EP06708567A patent/EP1855657B1/en not_active Revoked
-
2007
- 2007-04-13 FI FI20070153U patent/FI7750U1/en not_active IP Right Cessation
- 2007-08-26 IL IL185514A patent/IL185514A0/en unknown
- 2007-09-27 DK DK200700248U patent/DK200700248U3/en not_active IP Right Cessation
-
2008
- 2008-03-04 HK HK08102490.3A patent/HK1111604A1/en not_active IP Right Cessation
-
2009
- 2009-01-15 IL IL196539A patent/IL196539A0/en unknown
- 2009-03-13 AU AU2009201019A patent/AU2009201019B2/en not_active Ceased
-
2010
- 2010-11-12 US US12/945,164 patent/US20110172259A1/en not_active Abandoned
-
2011
- 2011-10-25 CY CY20111101011T patent/CY1111967T1/en unknown
- 2011-10-25 HR HR20110775T patent/HRP20110775T1/en unknown
- 2011-12-16 US US13/329,218 patent/US20120225901A1/en not_active Abandoned
-
2013
- 2013-10-02 US US14/044,175 patent/US20140031382A1/en not_active Abandoned
-
2014
- 2014-04-24 JP JP2014090036A patent/JP6235962B2/en active Active
-
2017
- 2017-03-23 US US15/467,877 patent/US20180008593A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2599156A1 (en) | Dosage form containing oxycodone and naloxone | |
| JP6226916B2 (en) | Pharmaceutical composition | |
| JP5203373B2 (en) | Mixed ORL1 / μ-agonist for the treatment of pain | |
| JP4898073B2 (en) | Fentanyl composition for intranasal administration | |
| RU2572692C2 (en) | Dexmedetomidine sublingual compositions and methods of application thereof | |
| CA2661759A1 (en) | Buprenophine-wafer for drug substitution therapy | |
| US20080145417A1 (en) | Pharmaceutical formulation for the efficient administration apomorphine, 6ar-(-)-n-propyl-norapomorphine and their derivatives and pro-drugs thereof | |
| US20230414572A1 (en) | Prevention or treatment of sleep disorders using dexmedetomidine formulation | |
| US20060100205A1 (en) | Compositions for affecting weight loss | |
| US10278953B2 (en) | Use of NK-1 receptor antagonist serlopitant in pruritus | |
| US20080021083A1 (en) | 4-Methylpyrazole Formulations for Inhibiting Ethanol Intolerance | |
| JP2007518755A (en) | Pharmaceutical composition comprising a monoamine neurotransmitter reuptake inhibitor and an N-methyl-D-aspartate (NMDA) receptor antagonist | |
| WO2014143201A1 (en) | Method for noribogaine treatment of addiction in patients on methadone | |
| US8637087B2 (en) | Treatment of interstitial cystitis using (6aR, 10aR)-Δ8-tetrahydrocannabinol-11-OIC acids | |
| US20080299207A1 (en) | Methods and compositions for administration of oxybutynin | |
| ES2255607T3 (en) | USE OF BUPRENORFINE FOR THE TREATMENT OF URINARY INCONTINENCE. | |
| US20060128738A1 (en) | Treatment of interstitial cystitis using cannabinoid analogs | |
| Kiersch et al. | The onset of action and the analgesic efficacy of Saridon®*(a propyphenazone/paracetamol/caffeine combination) in comparison with paracetamol, ibuprofen, aspirin and placebo (pooled statistical analysis) | |
| US20120029066A1 (en) | Use of flavones for treating psychiatric disorders with sensorimotor gating deficits | |
| EP2560646B1 (en) | Combination of a serotonin and norepinephrine reuptake inhibitor and an opioid agonist for the treatment of pain | |
| JPH11513386A (en) | Novel combinations of beta-receptor blockers and opioids | |
| CN117243947A (en) | Application of daphnetin and combination containing daphnetin in preparation of diabetes complication medicaments | |
| WO2007016771A1 (en) | Dosing regimen for weight loss | |
| CN113181178A (en) | Application of demethylenetetrahydroberberine hydrochloride in preparation of medicine for preventing or treating pain | |
| JP2000327571A (en) | Anti-itching composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |