CA2622697A1 - Crystalline forms of atorvastatin - Google Patents
Crystalline forms of atorvastatin Download PDFInfo
- Publication number
- CA2622697A1 CA2622697A1 CA002622697A CA2622697A CA2622697A1 CA 2622697 A1 CA2622697 A1 CA 2622697A1 CA 002622697 A CA002622697 A CA 002622697A CA 2622697 A CA2622697 A CA 2622697A CA 2622697 A1 CA2622697 A1 CA 2622697A1
- Authority
- CA
- Canada
- Prior art keywords
- intensity
- atorvastatin
- characteristic
- atorvastatin calcium
- ray powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title claims description 12
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 title description 11
- 229960005370 atorvastatin Drugs 0.000 title description 11
- OJRHUICOVVSGSY-RXMQYKEDSA-N (2s)-2-chloro-3-methylbutan-1-ol Chemical compound CC(C)[C@H](Cl)CO OJRHUICOVVSGSY-RXMQYKEDSA-N 0.000 claims abstract description 31
- 238000002360 preparation method Methods 0.000 claims abstract description 26
- 229960001770 atorvastatin calcium Drugs 0.000 claims abstract description 22
- 238000000034 method Methods 0.000 claims abstract description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 22
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 21
- 239000000725 suspension Substances 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 14
- 239000013078 crystal Substances 0.000 claims description 11
- 239000011575 calcium Substances 0.000 claims description 10
- 229910052791 calcium Inorganic materials 0.000 claims description 9
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 14
- 239000003960 organic solvent Substances 0.000 description 13
- 239000000243 solution Substances 0.000 description 9
- 239000002904 solvent Substances 0.000 description 9
- 238000010899 nucleation Methods 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 6
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 4
- OUCSEDFVYPBLLF-KAYWLYCHSA-N 5-(4-fluorophenyl)-1-[2-[(2r,4r)-4-hydroxy-6-oxooxan-2-yl]ethyl]-n,4-diphenyl-2-propan-2-ylpyrrole-3-carboxamide Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@H]2OC(=O)C[C@H](O)C2)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 OUCSEDFVYPBLLF-KAYWLYCHSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
- 238000002441 X-ray diffraction Methods 0.000 description 4
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000003863 ammonium salts Chemical class 0.000 description 3
- 239000000920 calcium hydroxide Substances 0.000 description 3
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 3
- 235000011116 calcium hydroxide Nutrition 0.000 description 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 3
- 238000000113 differential scanning calorimetry Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 3
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- 229940093499 ethyl acetate Drugs 0.000 description 2
- 235000019439 ethyl acetate Nutrition 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- -1 preferably a Substances 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- 229910014812 CaC6 Inorganic materials 0.000 description 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- 229910004373 HOAc Inorganic materials 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- XQKKWWCELHKGKB-UHFFFAOYSA-L calcium acetate monohydrate Chemical compound O.[Ca+2].CC([O-])=O.CC([O-])=O XQKKWWCELHKGKB-UHFFFAOYSA-L 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 1
- 230000000871 hypocholesterolemic effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- VVRPOCPLIUDBSA-CNZCJKERSA-M sodium;(3r,5r)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate Chemical compound [Na+].C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 VVRPOCPLIUDBSA-CNZCJKERSA-M 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
The present invention is directed to new crystalline forms of Atorvastatin calcium (2:1), referred to hereinafter as polymorphic Forms X, A, B, B2, C, D and E.
Furthermore, the present invention is directed to processes for the preparation of these crystalline forms and pharmaceutical compositions comprising the crystalline forms.
Furthermore, the present invention is directed to processes for the preparation of these crystalline forms and pharmaceutical compositions comprising the crystalline forms.
Description
CRYSTALLINE FORMS OF ATORVASTATIN
The present invention is directed to crystalline forms of Atorvastatin calcium, processes for their preparation and pharmaceutical compositions comprising these crystalline forms.
The present invention relates to crystalline forms of Atonrastatin calcium.
Atorvastatin calcium is known by the chemical name, [R-(R*,R*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyi-4-[(phenylamino)carbonyl]-1 H-pyn=ole-1-heptanoic acid calcium salt (2:1). Atorvastatin has the following formula:
HO
COzH
OH F
N
H ~ I
N
O
Atonrastatin calcium is an oraiiy-active hypocholesterolaemic, a liver-setective HMG-CoA
reductase inhibitor. Processes for the preparation of Atorvastatin calcium are described in US-A-5,298,627, US-A-5,273,995 and WO-A-97/03960, and pubiications by P.L.
Brower et al. in Tetrahedron Letters (1992), vol. 33, pages 2279-2282, K.L. Baumann et al. in Tetrahedron Letters (1992), vol. 33, pages 2283-2284 and A. Graul et al. in Drugs Future (1997), vol. 22, pages 956-968.
This calcium salt (2:1) is desirable since it enables Atorvastatin calcium to be conveniently formulated. The processes in the above mentioned patents and publications result in the preparation of amorphous Atorvastatin caicium.
The preparations of Atorvastatin calcium (2:1) described in WO-A-97/03958 and WO-A-97/03959 result in the isolation of crystalline Atonrastatin calcium with the polymorphic forms III, and 1, 11, and IV, respectively. However, there is still a need to produce Atorvastatin calcium in a reproducible, pure and crystalline form to enable formulations to meet exacting pharmaceutical requirements and specifications. Furthermore, it is economically desirable that the product is stable for extended periods of time without the need for specialised storage conditions.
Surprisingly, there have now been found several novel crystalline forms of Atorvastatin calcium salt (2:1), herein designated as Form X, Form A, Form B1, Form B2, Form C, Form D and Form E. The novel forms of the present invention have a good thermal stability and/or good solubility characterisitics.
Accordingly, the present invention is directed to the following polymorphic Forms X, A, B1, B2, C, D and E of Atorvastatin calcium salt (2:1).
A crystalline polymorph of [R-(R",R')]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1 H-pyrrole-1 -heptanoic acid calcium salt which exhibits a characteristic X-ray powder diffraction pattem with characteristic peaks expressed in d-values (A) at 27.9 (s), 20.9 (w), 18.9 (w), 16.1 (w), 11.1 (m), 10.5 (m), 9.1 (m), 5.53 (m), 5.07 (w), 4.77 (vw), 4.55 (m), 4.13 (w), 3.69 (w);
herein designated as Form X. Here and in the following the abbreviations in brackets mean:
(vs) = very strong intensity; (s) = strong intensity; (m) = medium intensity;
(w) = weak intensityy, (vw) = very weak intensity.
A crystalline polymorph of [R-(R*,R')]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyf-4-[(phenylamino)carbonyl]-1 H-pyrrole- 1 -heptanoic acid calcium salt which exhibits a characteristic X-ray powder diffraction pattem with characteristic peaks expressed in d-values (A) at 31.0 (vw), 18.6 (m), 17.0 (w), 15.3 (vw), 12.8 (w), 11.2 (m), 9.6 (s), 9.3 (w), 8.6 (w), 7.4 (m), 6.5 (vw), 6.2 (vw), 5.47 (w), 5.21 (m), 4.64 (vs), 4.46 (s), 4.14 (m), 3.97 (m), 3.74 (m), 3.62 (vw), 3.38 (w), 3.10 (m), herein designated as Form A.
A crystalline polymorph of [R-(R;,R')]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt which exhibits a characteristic X-ray powder diffraction pattem with characteristic peaks expressed in d-values (A) at 27.9 (m), 17.0 (m), 14.2 (w), 12.1 (vs), 10.1 (s), 8.6 (m), 7.1 (m), 6.1 (vw), 5.27 (m), 4.89 (m), 4.68 (m), 4.46 (m), 4.22 (m), 3.90 (w), 3.70 (w), 2.36 (vw), herein designated as Form B1.
= A crystalline polymorph of (R-(R*,R*)]-2-(4-fluorophenyl)-beta,deita-dihydroxy-5-(1-methyiethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1 H-pyrrole-l-heptanoic acid calcium salt which exhibits a characteristic X-ray powder diffraction pattem with characteristic peaks expressed in d-values (A) at 28.1 (m), 17.2 (m), 14.0 (vw), 12.3 (s), 10.4 (s), 8.6 (m), 7.5 (w), 7.0 (m), 5.28 (m), 4.88 (m), 4.55 (m), 4.27 (m), 3.88 (vw), 3.73 (m), herein designated as Form B2.
A crystalline polymorph of [R-(R*,R*)]-2-(4-fiuorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-l-heptanoic acid calcium salt which exhibits a characteristic X-ray powder diffraction pattem with characteristic peaks expressed in d-values (A) at 28.8 (m), 24.0 (m), 17.1 (rrm), 11.3 (s), 9.8 (vw), 8.3 (w), 7.7 (vw), 6.9 (vw), 5.64 (vw), 5.21 (w), 4.59 (m), 4.39 (w), 4.16 (w), 3.70 (w), herein designated as Form C.
A crystaiAne polymorph of [R-(R*,R*)1-2-(4-fluonophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonylj-lH-pyrrole-l-heptanoic acid calcium salt which exhibits a characteristic X-ray powder diffraction pattem with characteristic peaks expressed in d-values (A) at 33.7 (w), 31.0 (m), 16.9 (rn), 10.3 (s), 7.7 (w), 6.4 (vw), 4.84 (s), herein designated as Form D.
A crystalline polymorph of [R-(R*,R*)]-2-(4-fiuorophenyl)-beta,delta-dihydroxy-5-(1-methylethyi)-3-phenyl-4-[(phenylamino)carbonyl]-1 H-pyrrole-1 -heptanoic acid calcium saft which exhibits a characteristic X-ray powder diffraction pattem with characteristic peaks expressed in d-values (A) at 26.8 (s), 9.4 (w), 4.6 (m) herein designated as Form E.
A discussion of the theory of X-ray powder diffraction pattems can be found in 'X-ray diffraction procedures by H.P. Kiug and L.E. Alexander, J. Wiley, New York (1974).
Furthermore, the present invention is directed to processes for the preparation of Form X, Form A, Form B1, Form B2, Form C, Form D and Form E.
Form X can generally be prepared by drying of a solution of Atorvastatin caicium in an organic solvent. Examples of such organic solvents are alcohols, like methanol. Preferably, the solution in addition contains an organic non-solvent, like ethers, for example methyl tert.-butyl ether. Drying can be carried out at elevated temperature, or, preferably, at ambient temperature. If desired, during the preparation process seeding with Form X
can be carried out.
Form A can generally be prepared by suspending Form X or the amorphous form in an organic solvent, like an alcohol, especially isopnopanol. It is preferred that the organic solvent contains as a further solvent some water. The amount of water Is preferably about 0.1 to 5%, preferably about 0.5 to 2%, especiaiiy about 1% by volume of the suspension.
It is preferred that the suspension is treated at temperatures between 10 and 60 C (preferably 30 to 50 C), especially for a longer period of time, like 10 to 40 hours. If desired, during the preparation process seeding with Form A can be carried out.
Form A can also be prepared from Atorvastatin lacton upon subsequent reaction with NaOH
to form Atorvastatin sodium followed by reaction with CaC6 in an organic solvent, like an alcohol, especially isopropanol. It is prefered that the organic solvent contains as a further solvent some water. The amount of water is preferably 0.1 to 10%. if desired, during the preparation process seeding with Form A can be carried out.
Form A can also be prepared directly from Atorvastatin lactone upon reaction with Ca(OH)2 in an organic solvent, like an alcohol, especially isopropanol. It is prefered that the organic solvent contains as a further solvent some water. The amount of water is preferably 0.1 to 10%. If desired, during the preparation process seeding with Form A can be carried out.
Form A can also be prepared by the reaction of Atorvastatln ammonium salt with Ca(li)-acetate in an organic solvent or a mixture of organic solvents, preferably a,mixture of tert-butyl methyl ether (TBME) and isopropanol. The solid formed in this reaction is isolated by filtration and than stirred as a suspension in an organic solvent, like an alcohol, especially isopropanol. it ts prefered that the organic solvent contains as a further solvent some water.
The amount of water is preferably 0.1 to 10%. It is prefered that the suspension is treated at temperatures between 10 and 60 C, especially for a longer period of time, like 10 to 60 = hours. If desired, during the preparation process seeding with Form A can be carried out.
Form Bi can generally be prepared by suspending Form X or the amorphous form in acetonitrile containing a further organic solvent, like tetrahydrofuran. It is prefered that the suspension is treated at temperatures between 10 and 50 C (preferably ambient temperature), especially for a longer period of time, like 10 to 40 hours. if desired, during the preparation process seeding with Form B1 can be carried out.
Form B2 can generally be prepared by suspending Form X or the amorphous form in acetonitrile, preferably pure acetonitrife. It is preferred that the suspension is treated at temperatures between 10 and 50 C (preferabiy 30 to 50 C), especially for a longer period of time, like 10 to 40 hours. If desired, during the preparation process seeding with Form B2 can be carried out.
Form C can generally be prepared by suspending Form X or the amorphous form in a mixture of isopropanol and water, and treating the suspension at ambient temperature for a longer period of time, like 10 to 40 hours. If desired, during the preparation process seeding with Form C can be carried out.
Form D can generally be prepared by suspending Form X or the amorphous form in a mixture of ethanol and water at temperatures between about 20 to 60 C for a longer period of time, like 10 to 40 hours. If desired, during the preparation process seecf'ing with Form D
can be carried out.
Form E can generaiiy be prepared by evaporation of a solution of any form of Atorvastatin, = preferably Form X, in 2-butanone or from solvent mixtures of 2-butanone with heptane or ethylacetate or temary mixtures of 2-butanone, heptane and ethylacetate.
Evaporation is preferably carried out siowiy, for example within 10 to 40 hours.
The present invention is directed to crystalline forms of Atorvastatin calcium, processes for their preparation and pharmaceutical compositions comprising these crystalline forms.
The present invention relates to crystalline forms of Atonrastatin calcium.
Atorvastatin calcium is known by the chemical name, [R-(R*,R*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyi-4-[(phenylamino)carbonyl]-1 H-pyn=ole-1-heptanoic acid calcium salt (2:1). Atorvastatin has the following formula:
HO
COzH
OH F
N
H ~ I
N
O
Atonrastatin calcium is an oraiiy-active hypocholesterolaemic, a liver-setective HMG-CoA
reductase inhibitor. Processes for the preparation of Atorvastatin calcium are described in US-A-5,298,627, US-A-5,273,995 and WO-A-97/03960, and pubiications by P.L.
Brower et al. in Tetrahedron Letters (1992), vol. 33, pages 2279-2282, K.L. Baumann et al. in Tetrahedron Letters (1992), vol. 33, pages 2283-2284 and A. Graul et al. in Drugs Future (1997), vol. 22, pages 956-968.
This calcium salt (2:1) is desirable since it enables Atorvastatin calcium to be conveniently formulated. The processes in the above mentioned patents and publications result in the preparation of amorphous Atorvastatin caicium.
The preparations of Atorvastatin calcium (2:1) described in WO-A-97/03958 and WO-A-97/03959 result in the isolation of crystalline Atonrastatin calcium with the polymorphic forms III, and 1, 11, and IV, respectively. However, there is still a need to produce Atorvastatin calcium in a reproducible, pure and crystalline form to enable formulations to meet exacting pharmaceutical requirements and specifications. Furthermore, it is economically desirable that the product is stable for extended periods of time without the need for specialised storage conditions.
Surprisingly, there have now been found several novel crystalline forms of Atorvastatin calcium salt (2:1), herein designated as Form X, Form A, Form B1, Form B2, Form C, Form D and Form E. The novel forms of the present invention have a good thermal stability and/or good solubility characterisitics.
Accordingly, the present invention is directed to the following polymorphic Forms X, A, B1, B2, C, D and E of Atorvastatin calcium salt (2:1).
A crystalline polymorph of [R-(R",R')]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1 H-pyrrole-1 -heptanoic acid calcium salt which exhibits a characteristic X-ray powder diffraction pattem with characteristic peaks expressed in d-values (A) at 27.9 (s), 20.9 (w), 18.9 (w), 16.1 (w), 11.1 (m), 10.5 (m), 9.1 (m), 5.53 (m), 5.07 (w), 4.77 (vw), 4.55 (m), 4.13 (w), 3.69 (w);
herein designated as Form X. Here and in the following the abbreviations in brackets mean:
(vs) = very strong intensity; (s) = strong intensity; (m) = medium intensity;
(w) = weak intensityy, (vw) = very weak intensity.
A crystalline polymorph of [R-(R*,R')]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyf-4-[(phenylamino)carbonyl]-1 H-pyrrole- 1 -heptanoic acid calcium salt which exhibits a characteristic X-ray powder diffraction pattem with characteristic peaks expressed in d-values (A) at 31.0 (vw), 18.6 (m), 17.0 (w), 15.3 (vw), 12.8 (w), 11.2 (m), 9.6 (s), 9.3 (w), 8.6 (w), 7.4 (m), 6.5 (vw), 6.2 (vw), 5.47 (w), 5.21 (m), 4.64 (vs), 4.46 (s), 4.14 (m), 3.97 (m), 3.74 (m), 3.62 (vw), 3.38 (w), 3.10 (m), herein designated as Form A.
A crystalline polymorph of [R-(R;,R')]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt which exhibits a characteristic X-ray powder diffraction pattem with characteristic peaks expressed in d-values (A) at 27.9 (m), 17.0 (m), 14.2 (w), 12.1 (vs), 10.1 (s), 8.6 (m), 7.1 (m), 6.1 (vw), 5.27 (m), 4.89 (m), 4.68 (m), 4.46 (m), 4.22 (m), 3.90 (w), 3.70 (w), 2.36 (vw), herein designated as Form B1.
= A crystalline polymorph of (R-(R*,R*)]-2-(4-fluorophenyl)-beta,deita-dihydroxy-5-(1-methyiethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1 H-pyrrole-l-heptanoic acid calcium salt which exhibits a characteristic X-ray powder diffraction pattem with characteristic peaks expressed in d-values (A) at 28.1 (m), 17.2 (m), 14.0 (vw), 12.3 (s), 10.4 (s), 8.6 (m), 7.5 (w), 7.0 (m), 5.28 (m), 4.88 (m), 4.55 (m), 4.27 (m), 3.88 (vw), 3.73 (m), herein designated as Form B2.
A crystalline polymorph of [R-(R*,R*)]-2-(4-fiuorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-l-heptanoic acid calcium salt which exhibits a characteristic X-ray powder diffraction pattem with characteristic peaks expressed in d-values (A) at 28.8 (m), 24.0 (m), 17.1 (rrm), 11.3 (s), 9.8 (vw), 8.3 (w), 7.7 (vw), 6.9 (vw), 5.64 (vw), 5.21 (w), 4.59 (m), 4.39 (w), 4.16 (w), 3.70 (w), herein designated as Form C.
A crystaiAne polymorph of [R-(R*,R*)1-2-(4-fluonophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonylj-lH-pyrrole-l-heptanoic acid calcium salt which exhibits a characteristic X-ray powder diffraction pattem with characteristic peaks expressed in d-values (A) at 33.7 (w), 31.0 (m), 16.9 (rn), 10.3 (s), 7.7 (w), 6.4 (vw), 4.84 (s), herein designated as Form D.
A crystalline polymorph of [R-(R*,R*)]-2-(4-fiuorophenyl)-beta,delta-dihydroxy-5-(1-methylethyi)-3-phenyl-4-[(phenylamino)carbonyl]-1 H-pyrrole-1 -heptanoic acid calcium saft which exhibits a characteristic X-ray powder diffraction pattem with characteristic peaks expressed in d-values (A) at 26.8 (s), 9.4 (w), 4.6 (m) herein designated as Form E.
A discussion of the theory of X-ray powder diffraction pattems can be found in 'X-ray diffraction procedures by H.P. Kiug and L.E. Alexander, J. Wiley, New York (1974).
Furthermore, the present invention is directed to processes for the preparation of Form X, Form A, Form B1, Form B2, Form C, Form D and Form E.
Form X can generally be prepared by drying of a solution of Atorvastatin caicium in an organic solvent. Examples of such organic solvents are alcohols, like methanol. Preferably, the solution in addition contains an organic non-solvent, like ethers, for example methyl tert.-butyl ether. Drying can be carried out at elevated temperature, or, preferably, at ambient temperature. If desired, during the preparation process seeding with Form X
can be carried out.
Form A can generally be prepared by suspending Form X or the amorphous form in an organic solvent, like an alcohol, especially isopnopanol. It is preferred that the organic solvent contains as a further solvent some water. The amount of water Is preferably about 0.1 to 5%, preferably about 0.5 to 2%, especiaiiy about 1% by volume of the suspension.
It is preferred that the suspension is treated at temperatures between 10 and 60 C (preferably 30 to 50 C), especially for a longer period of time, like 10 to 40 hours. If desired, during the preparation process seeding with Form A can be carried out.
Form A can also be prepared from Atorvastatin lacton upon subsequent reaction with NaOH
to form Atorvastatin sodium followed by reaction with CaC6 in an organic solvent, like an alcohol, especially isopropanol. It is prefered that the organic solvent contains as a further solvent some water. The amount of water is preferably 0.1 to 10%. if desired, during the preparation process seeding with Form A can be carried out.
Form A can also be prepared directly from Atorvastatin lactone upon reaction with Ca(OH)2 in an organic solvent, like an alcohol, especially isopropanol. It is prefered that the organic solvent contains as a further solvent some water. The amount of water is preferably 0.1 to 10%. If desired, during the preparation process seeding with Form A can be carried out.
Form A can also be prepared by the reaction of Atorvastatln ammonium salt with Ca(li)-acetate in an organic solvent or a mixture of organic solvents, preferably a,mixture of tert-butyl methyl ether (TBME) and isopropanol. The solid formed in this reaction is isolated by filtration and than stirred as a suspension in an organic solvent, like an alcohol, especially isopropanol. it ts prefered that the organic solvent contains as a further solvent some water.
The amount of water is preferably 0.1 to 10%. It is prefered that the suspension is treated at temperatures between 10 and 60 C, especially for a longer period of time, like 10 to 60 = hours. If desired, during the preparation process seeding with Form A can be carried out.
Form Bi can generally be prepared by suspending Form X or the amorphous form in acetonitrile containing a further organic solvent, like tetrahydrofuran. It is prefered that the suspension is treated at temperatures between 10 and 50 C (preferably ambient temperature), especially for a longer period of time, like 10 to 40 hours. if desired, during the preparation process seeding with Form B1 can be carried out.
Form B2 can generally be prepared by suspending Form X or the amorphous form in acetonitrile, preferably pure acetonitrife. It is preferred that the suspension is treated at temperatures between 10 and 50 C (preferabiy 30 to 50 C), especially for a longer period of time, like 10 to 40 hours. If desired, during the preparation process seeding with Form B2 can be carried out.
Form C can generally be prepared by suspending Form X or the amorphous form in a mixture of isopropanol and water, and treating the suspension at ambient temperature for a longer period of time, like 10 to 40 hours. If desired, during the preparation process seeding with Form C can be carried out.
Form D can generally be prepared by suspending Form X or the amorphous form in a mixture of ethanol and water at temperatures between about 20 to 60 C for a longer period of time, like 10 to 40 hours. If desired, during the preparation process seecf'ing with Form D
can be carried out.
Form E can generaiiy be prepared by evaporation of a solution of any form of Atorvastatin, = preferably Form X, in 2-butanone or from solvent mixtures of 2-butanone with heptane or ethylacetate or temary mixtures of 2-butanone, heptane and ethylacetate.
Evaporation is preferably carried out siowiy, for example within 10 to 40 hours.
Another object of the present invention are pharmaceutical compositions comprising an etJ'ective amount of crystalline polymorphic Forin X, Form A, Form B1, Form B2, Form C, Form D or Form E, and a pharmaceutical acceptable carrier.
The polymorphic forms may be used as single components or mixtures.
As to the novel polymorphic forms of Atorvastatin calcium it is prefered that these contain 25-100% by weight, especially 50-100% by weight, of at least one of the novel forms, based on the total amount of Atorvastatin calcium. Preferably, such an amount of the novel polymorphic forms of Atorvastatin calcium is 75-100% by weight, especially 90-100% by weight.
Highly prefered is an amount of 95-100% by weight.
The following Examples illustrate the invention in more detail. Temperatures are given in degrees Celsius.
In the following Examples:
Figure 1 is a characteristic X-ray powder diffraction pattern for Form X;
Figure 2 is a characteristic X-ray powder diffraction pattern for Form A;
Figure 3 are characteristic X-ray powder diffraction patterns for Form B1 and B2;
Figure 4 is a characteristic X-ray powder diffraction pattern for Form C;
Figure 5 is a characteristic X-ray powder diffraction pattern for Form D;
Figure 6 are characteristic Differential Scanning Calorimetry (DSC) scans of Form A and Form X; and Figure 7 is a characteristic X-ray powder diffraction pattern for Form E.
Example 1: Preparation of polymoiphic Form X
Atorvastatin calcium Form X is prepared by dissolving 127 mg Atorvastatin calcium in a mixture of 2.0 ml methanol and 6.0 ml methyl tert.-butyl ether and drying of the solution at ambient temperature. Form X is characterized by a x-ray powder diffraction pattern as shown in Figure 1.
Differential scanning calorimetry in a closed sample pan sealed after equilibrium under dry nitrogen for about 16 hours at ambient temperature shows a melting point of 168 C and an enthalpy of fusion of about 27 Jl'g (see Figure 6). Form X if stored under normal conditions contains about 41'o of water.
The polymorphic forms may be used as single components or mixtures.
As to the novel polymorphic forms of Atorvastatin calcium it is prefered that these contain 25-100% by weight, especially 50-100% by weight, of at least one of the novel forms, based on the total amount of Atorvastatin calcium. Preferably, such an amount of the novel polymorphic forms of Atorvastatin calcium is 75-100% by weight, especially 90-100% by weight.
Highly prefered is an amount of 95-100% by weight.
The following Examples illustrate the invention in more detail. Temperatures are given in degrees Celsius.
In the following Examples:
Figure 1 is a characteristic X-ray powder diffraction pattern for Form X;
Figure 2 is a characteristic X-ray powder diffraction pattern for Form A;
Figure 3 are characteristic X-ray powder diffraction patterns for Form B1 and B2;
Figure 4 is a characteristic X-ray powder diffraction pattern for Form C;
Figure 5 is a characteristic X-ray powder diffraction pattern for Form D;
Figure 6 are characteristic Differential Scanning Calorimetry (DSC) scans of Form A and Form X; and Figure 7 is a characteristic X-ray powder diffraction pattern for Form E.
Example 1: Preparation of polymoiphic Form X
Atorvastatin calcium Form X is prepared by dissolving 127 mg Atorvastatin calcium in a mixture of 2.0 ml methanol and 6.0 ml methyl tert.-butyl ether and drying of the solution at ambient temperature. Form X is characterized by a x-ray powder diffraction pattern as shown in Figure 1.
Differential scanning calorimetry in a closed sample pan sealed after equilibrium under dry nitrogen for about 16 hours at ambient temperature shows a melting point of 168 C and an enthalpy of fusion of about 27 Jl'g (see Figure 6). Form X if stored under normal conditions contains about 41'o of water.
Example 2: Preparation of polymorphic Form A
Form A is prepared by suspending 100 mg of Form X in 3.0 ml isopropanol together with 50 l H,0 and stirring of this suspension at 40 C. After 9 hours an additional amount of 50 l of water is added to the suspension and stirring is continued at 40 C for another 20 hours. The suspension is filtrated and crystalline Form A is obtained. Form A is characterized by a x-ray powder diffraction pattern as shown in Figure 2. Differential scanning calorimetry of Form A in a closed sample pan sealed after equilibration under dry nitrogen for about 16 hours at ambient temperature reveals a melting point of 179 C and an enthalpy of fusion of 53 J/g (see Figure 6).
In the above example it is also possible to start from the amorphous form of Atorvastatin caicium instead of Form X.
Example 3: Preparation of polymorphic Form B 1 Atorvastatin calcium crystal Form B I is prepared by suspending 145 mg of Atorvastatin calcium Form X in a mixture of 1.0 ml acetonitrile and 1.0 ml of tetrahydrofuran at ambient temper ure.
While the cap of the reaction vial is left open some of the tetrahydrofuran evaporates which leads to a slow reduction of the solubility of Atorvastatin calcium in the system.
After 3.5 hours an additional amount of 1.0 ml of acetonitrile is added to the reaction container and stirring is continued for about 15 hours at ambient temperature. After filtration of the suspension crystal form B1 is obtained. Form B1 is characterized by a x-ray powder diffraction pattern as shown in Figure 3.
In the above example it is also possible to start from the amorphous form of Atorvastatin calcium instead of Form X.
Example 4: Preparation of polymorphic Form B2 Form B2 is prepared by suspending 117 mg of Atorvastatin calcium Form X in 2.0 ml of acetonitrile and stirring this suspension at 40"C for about 18 hours. In order to reduce the viscosity of the suspension 1.0 ml of acetonitrile is added at ambient temperature to this suspension after the end of the crystallization process. The obtained product is crystal Fotm B2 which is characterized by an x-ray powder diffraction pattern as shown in Figure 3.
In the above example it is also possible to start from the amorphous form of Atorvastatin calcium instead of Form X.
Example 5: Preparation ofpolymorphic Form C
Fotm C is prepared by suspending 120 mg of Atorvastatin calcium Form X in a mixture of 3.0 ml isopropanol and 1.0 ml water. After one hour of stirring at ambient temperature 2.Oml water are added and stirring is continued for 15 hours at the same temperature. After filtration of the suspension crystal Form C is obtained which is characterized by the x-ray diffraction pattern as shown in Figure 4.
In the above example it is also possible to start from the amorphous form of Atorvastatin calcium instead of Form X.
Example 6: Preparation of polymorphic Form D
Fotm D is prepared by suspending 124 mg of Form X in 3.0 ml of ethanol and by stirring this suspension at ambient temperature. After about 2 hours a suspension of higb viscosity is obtained and 1.0 ml of water are added to the suspension, which reduces the viscosity substantially. After addition of water, the temperature is slowly raised to 40 C and stirring is continued at 40 C for about 16 hours. After 6ltration of the suspension crystal Form D is obtained which is characterized by the x-ray diffraction pattern as shown in Figure 5.
In the above example it is also possible to start from the amorphous form of Atorvastatin calcium instead of Form X.
Example 7: Preparation of polymorphic Form E
60 mg of Atorvastatin Form X are dissolved in 2.0 ml 2-butanone (e.g. Fluka No. 04380) and then 2.0 ml of heptane (e.g. Fluka No. 51745) are added at ambient temperature. This mixture is heated to 50 C for a few minutes until all solid residues are dissolved. The mixture is then slowly cooled to 5 C and later equilibrated at ambient temperature. At ambient temperature the solvent is slowly evaporated within about 10 to 20 hours. After complete evaporation of the solvent Atorvastatin Form E is obtained as a solid residue. The X-ray diffraction pattern of Form E is shown in Figure 7.
Example 8:
OH OH O OH OH O
OH O'NH4+
H N N
F NH3/EtOH H F HOAc, 35 C
I ~ N N
~ O O
I II
O OH OH O
" O H O-N - Ca(OH)2 T
Caz+
F iPrOH/H20 N \ F
N
III IV
a) Preparation of Atorvastatin lactone III:
Diol acid 1(5 g, 8.9 mmol) is dissolved in 10.7 ml ethanol and 5.6 ml 1.6 M
NH3 in ethanol is added at room temperature. The solution is being stirred over 15 to 30 minutes and the solvent is subsequently removed under reduced pressure to give a colorless or slightly beige foam (5.15 g, approximately 100% yield).
Ammonium salt 11 (23.91 g, 41.7 mmol) is dissolved in 115 ml acetic acid. The yellow solution is being stirred at 35 C for approximately 16 h. 200 ml dioxane are added twice and the mixture is being concentrated at 40 C and 35 mbar pressure, respectively. The residue is dissolved in 200 ml TBME and being washing with water and brine and dried over magnesium sulfate. Removal of the solvent affords 21.4g (approx. 95% yield) Atorvastatin lactone III.
b) Preparation of Atorvastatin calcium Form A starting from Atorvastatin lactone III:
Lactone III (20.6 g, 38.2 mmol) is dissolved in 757 ml 2-propanol/water (19:1) and 1.41 g (0.5 eq) calcium hydroxide is added. The turbid solution is stirred at 40 C for 3 d whereupon the solution turns into a thick suspension. White crystals of form A are collected by filtration and being dried at 70 C and 20 mbar pressure overnight. Yield: 19.0 g, 86%.
Example 9: Preparation of Atorvastatin calcium Form A starting from Atorvastatin ammonium salt 11:
Ammonium salt 11 (2 g, 3.5 mmol) is dissolved in 20 ml TBME/isopropanol (1:2) and a solution of calcium acetate hydrate (0.5 eq) is added dropwise at room temperature. The precipitated calcium salt is collected by filtration and dried at 70 C and 20 mbar. (Yield 1.6 g, approx. 80%.) The obtained powder is subsequently being stirred in 58 ml propanol/water (19:1) at 40 C and seeded with 5 % crystals of form A. After 4 d Atorvastatin Calcium form A can be collected by filtration (yield 1.5 g, 91%).
Form A is prepared by suspending 100 mg of Form X in 3.0 ml isopropanol together with 50 l H,0 and stirring of this suspension at 40 C. After 9 hours an additional amount of 50 l of water is added to the suspension and stirring is continued at 40 C for another 20 hours. The suspension is filtrated and crystalline Form A is obtained. Form A is characterized by a x-ray powder diffraction pattern as shown in Figure 2. Differential scanning calorimetry of Form A in a closed sample pan sealed after equilibration under dry nitrogen for about 16 hours at ambient temperature reveals a melting point of 179 C and an enthalpy of fusion of 53 J/g (see Figure 6).
In the above example it is also possible to start from the amorphous form of Atorvastatin caicium instead of Form X.
Example 3: Preparation of polymorphic Form B 1 Atorvastatin calcium crystal Form B I is prepared by suspending 145 mg of Atorvastatin calcium Form X in a mixture of 1.0 ml acetonitrile and 1.0 ml of tetrahydrofuran at ambient temper ure.
While the cap of the reaction vial is left open some of the tetrahydrofuran evaporates which leads to a slow reduction of the solubility of Atorvastatin calcium in the system.
After 3.5 hours an additional amount of 1.0 ml of acetonitrile is added to the reaction container and stirring is continued for about 15 hours at ambient temperature. After filtration of the suspension crystal form B1 is obtained. Form B1 is characterized by a x-ray powder diffraction pattern as shown in Figure 3.
In the above example it is also possible to start from the amorphous form of Atorvastatin calcium instead of Form X.
Example 4: Preparation of polymorphic Form B2 Form B2 is prepared by suspending 117 mg of Atorvastatin calcium Form X in 2.0 ml of acetonitrile and stirring this suspension at 40"C for about 18 hours. In order to reduce the viscosity of the suspension 1.0 ml of acetonitrile is added at ambient temperature to this suspension after the end of the crystallization process. The obtained product is crystal Fotm B2 which is characterized by an x-ray powder diffraction pattern as shown in Figure 3.
In the above example it is also possible to start from the amorphous form of Atorvastatin calcium instead of Form X.
Example 5: Preparation ofpolymorphic Form C
Fotm C is prepared by suspending 120 mg of Atorvastatin calcium Form X in a mixture of 3.0 ml isopropanol and 1.0 ml water. After one hour of stirring at ambient temperature 2.Oml water are added and stirring is continued for 15 hours at the same temperature. After filtration of the suspension crystal Form C is obtained which is characterized by the x-ray diffraction pattern as shown in Figure 4.
In the above example it is also possible to start from the amorphous form of Atorvastatin calcium instead of Form X.
Example 6: Preparation of polymorphic Form D
Fotm D is prepared by suspending 124 mg of Form X in 3.0 ml of ethanol and by stirring this suspension at ambient temperature. After about 2 hours a suspension of higb viscosity is obtained and 1.0 ml of water are added to the suspension, which reduces the viscosity substantially. After addition of water, the temperature is slowly raised to 40 C and stirring is continued at 40 C for about 16 hours. After 6ltration of the suspension crystal Form D is obtained which is characterized by the x-ray diffraction pattern as shown in Figure 5.
In the above example it is also possible to start from the amorphous form of Atorvastatin calcium instead of Form X.
Example 7: Preparation of polymorphic Form E
60 mg of Atorvastatin Form X are dissolved in 2.0 ml 2-butanone (e.g. Fluka No. 04380) and then 2.0 ml of heptane (e.g. Fluka No. 51745) are added at ambient temperature. This mixture is heated to 50 C for a few minutes until all solid residues are dissolved. The mixture is then slowly cooled to 5 C and later equilibrated at ambient temperature. At ambient temperature the solvent is slowly evaporated within about 10 to 20 hours. After complete evaporation of the solvent Atorvastatin Form E is obtained as a solid residue. The X-ray diffraction pattern of Form E is shown in Figure 7.
Example 8:
OH OH O OH OH O
OH O'NH4+
H N N
F NH3/EtOH H F HOAc, 35 C
I ~ N N
~ O O
I II
O OH OH O
" O H O-N - Ca(OH)2 T
Caz+
F iPrOH/H20 N \ F
N
III IV
a) Preparation of Atorvastatin lactone III:
Diol acid 1(5 g, 8.9 mmol) is dissolved in 10.7 ml ethanol and 5.6 ml 1.6 M
NH3 in ethanol is added at room temperature. The solution is being stirred over 15 to 30 minutes and the solvent is subsequently removed under reduced pressure to give a colorless or slightly beige foam (5.15 g, approximately 100% yield).
Ammonium salt 11 (23.91 g, 41.7 mmol) is dissolved in 115 ml acetic acid. The yellow solution is being stirred at 35 C for approximately 16 h. 200 ml dioxane are added twice and the mixture is being concentrated at 40 C and 35 mbar pressure, respectively. The residue is dissolved in 200 ml TBME and being washing with water and brine and dried over magnesium sulfate. Removal of the solvent affords 21.4g (approx. 95% yield) Atorvastatin lactone III.
b) Preparation of Atorvastatin calcium Form A starting from Atorvastatin lactone III:
Lactone III (20.6 g, 38.2 mmol) is dissolved in 757 ml 2-propanol/water (19:1) and 1.41 g (0.5 eq) calcium hydroxide is added. The turbid solution is stirred at 40 C for 3 d whereupon the solution turns into a thick suspension. White crystals of form A are collected by filtration and being dried at 70 C and 20 mbar pressure overnight. Yield: 19.0 g, 86%.
Example 9: Preparation of Atorvastatin calcium Form A starting from Atorvastatin ammonium salt 11:
Ammonium salt 11 (2 g, 3.5 mmol) is dissolved in 20 ml TBME/isopropanol (1:2) and a solution of calcium acetate hydrate (0.5 eq) is added dropwise at room temperature. The precipitated calcium salt is collected by filtration and dried at 70 C and 20 mbar. (Yield 1.6 g, approx. 80%.) The obtained powder is subsequently being stirred in 58 ml propanol/water (19:1) at 40 C and seeded with 5 % crystals of form A. After 4 d Atorvastatin Calcium form A can be collected by filtration (yield 1.5 g, 91%).
Claims (4)
1. A process for the preparation of a crystalline form of [R-(R*,R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (atorvastatin calcium crystal Form C) which exhibits a characteristic X-ray powder diffraction pattern with characteristic peaks expressed in d-values (.ANG.) at 28.8 (m), 24.0 (m), 17.1 (m), 11.3 (s), 9.8 (vw), 8.3 (w), 7.7 (vw), 6.9 (vw), 5.64 (vw), 5.21 (w), 4.59 (m), 4.39 (w), 4.16 (w), 3.70 (w); wherein (s)= strong intensity; (m) = medium intensity; (w) = weak intensity; (vw) = very weak intensity;
which comprises suspending amorphous atorvastatin calcium or atorvastatin calcium crystal Form X which exhibits a characteristic X-ray powder diffraction pattern with characteristic peaks expressed in d-values (.ANG.) at 27.9 (s), 20.9 (w), 18.9 (w), 16.1 (w), 11.1 (m), 10.5 (m), 9.1 (m), 5.53 (m), 5.07 (w), 4.77 (vw), 4.55 (m), 4.13 (w), 3.69 (w); wherein (s) = strong intensity ;
(m) =
medium intensity; (w) = weak intensity; (vw) = very weak intensity;
in a mixture of isopropanol and water and treating the suspension at ambient temperature.
which comprises suspending amorphous atorvastatin calcium or atorvastatin calcium crystal Form X which exhibits a characteristic X-ray powder diffraction pattern with characteristic peaks expressed in d-values (.ANG.) at 27.9 (s), 20.9 (w), 18.9 (w), 16.1 (w), 11.1 (m), 10.5 (m), 9.1 (m), 5.53 (m), 5.07 (w), 4.77 (vw), 4.55 (m), 4.13 (w), 3.69 (w); wherein (s) = strong intensity ;
(m) =
medium intensity; (w) = weak intensity; (vw) = very weak intensity;
in a mixture of isopropanol and water and treating the suspension at ambient temperature.
2. A crystalline polymorph of [R-(R*,R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (atorvastatin calcium crystal Form C) which exhibits a characteristic X-ray powder diffraction pattern with characteristic peaks expressed in d-values (.ANG.) at 28.8 (m), 24.0 (m), 17.1 (m), 11.3 (s), 9.8 (vw), 8.3 (w), 7.7 (vw), 6.9 (vw), 5.64 (vw), 5.21 (w), 4.59 (m), 4.39 (w), 4.16 (w), 3.70 (w); wherein (s) = strong intensity; (m) = medium intensity; (w) = weak intensity; (vw) = very weak intensity.
3. A pharmaceutical composition comprising atorvastatin calcium crystal Form C
according to claim 2, and a pharmaceutical acceptable carrier.
according to claim 2, and a pharmaceutical acceptable carrier.
4. The process of claim 1 where treating occurs for 10 to 40 hours.
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CA002623599A Abandoned CA2623599A1 (en) | 2000-12-27 | 2001-12-19 | Crystalline forms of atorvastatin |
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CA002622727A Abandoned CA2622727A1 (en) | 2000-12-27 | 2001-12-19 | Crystalline forms of atorvastatin |
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PT (1) | PT1345896E (en) |
SK (1) | SK9532003A3 (en) |
WO (1) | WO2002051804A1 (en) |
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US7074818B2 (en) | 2001-07-30 | 2006-07-11 | Dr. Reddy's Laboratories Limited | Crystalline forms VI and VII of Atorvastatin calcium |
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WO2004022053A1 (en) * | 2002-09-03 | 2004-03-18 | Morepen Laboratories Limited | Atorvastatin calcium form vi or hydrates thereof |
EP1424324A1 (en) * | 2002-11-28 | 2004-06-02 | Teva Pharmaceutical Industries Limited | Crystalline form F of Atorvastatin hemi-calcium salt |
WO2004050618A2 (en) * | 2002-11-28 | 2004-06-17 | Teva Pharmaceutical Industries Ltd. | Crystalline form f of atorvastatin hemi-calcium salt |
US7655692B2 (en) | 2003-06-12 | 2010-02-02 | Pfizer Inc. | Process for forming amorphous atorvastatin |
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PT1727795E (en) | 2004-03-17 | 2012-04-11 | Ranbaxy Lab Ltd | Process for the production of atorvastatin calcium in amorphous form |
ES2739493T3 (en) | 2004-05-05 | 2020-01-31 | Pfizer Prod Inc | Salt forms of atorvastatin with benetamine |
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ES2586561T3 (en) * | 2004-07-16 | 2016-10-17 | Lek Pharmaceuticals D.D. | Atorvastatin calcium oxidative degradation products |
JP2008506764A (en) | 2004-07-20 | 2008-03-06 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | [R- (R *, R *)]-2- (4-fluorophenyl) -β, δ-dihydroxy-5- (1-methylethyl) -3-phenyl-4-[(phenylamino) carbonyl]- Novel form of 1H-pyrrole-1-heptanoic acid calcium salt (2: 1) |
AU2005298383A1 (en) | 2004-10-28 | 2006-05-04 | Warner-Lambert Company Llc | Process for forming amorphous atorvastatin |
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CA2499047A1 (en) * | 2005-03-01 | 2006-09-01 | Apotex Pharmachem Inc. | Process for producing atorvastatin hemicalcium |
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TW200745026A (en) | 2005-12-13 | 2007-12-16 | Teva Pharma | Crystal form of atorvastatin hemi-calcium and processes for preparation thereof |
EP1810667A1 (en) | 2006-01-20 | 2007-07-25 | KRKA, tovarna zdravil, d.d., Novo mesto | Pharmaceutical composition comprising amorphous atorvastatin |
KR20080031487A (en) * | 2006-06-28 | 2008-04-08 | 테바 파마슈티컬 인더스트리즈 리미티드 | Crystalline forms of atorvastatin |
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KR20120011249A (en) * | 2010-07-28 | 2012-02-07 | 주식회사 경보제약 | Novel Crystal Form of Atorvastatin Hemi-Calcium, Hydrate thereof, and Method of Producing the Same |
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JP2019167295A (en) * | 2016-07-04 | 2019-10-03 | ゼリア新薬工業株式会社 | Method for producing calcium salt of 1, 5-benzodiazepine compound |
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PT1148049E (en) * | 1995-07-17 | 2005-02-28 | Warner Lambert Co | [R- (R *, R *)] - 2- (4-FLUOROPHENYL) -BETA, DELTA-DIHYDROXY-5- (1-METHYLETHYL) -3-PHENYL-4-PHARMACEUTICAL CRYSTALLINES OF CALCIUM HEMI- [(PHENYLAMINO) -CARBONYL) -1H-PYRROLE-1-HEPTANOIC ACID (ATORVASTATIN) |
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CA2391357C (en) * | 1999-12-17 | 2009-01-06 | Warner Lambert Research And Development Ireland Limited | A process for producing crystalline atorvastatin calcium |
PL362472A1 (en) * | 2000-11-03 | 2004-11-02 | Teva Pharma | Atorvastatin hemi-calcium form vii |
IL156055A0 (en) * | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
WO2002051804A1 (en) * | 2000-12-27 | 2002-07-04 | Ciba Specialty Chemicals Holding Inc. | Crystalline forms of atorvastatin |
WO2002057228A1 (en) | 2001-01-17 | 2002-07-25 | Biocon India Limited | Atorvastatin calcium |
WO2002057229A1 (en) | 2001-01-19 | 2002-07-25 | Biocon India Limited | FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN) |
SI20814A (en) | 2001-01-23 | 2002-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Preparation of amorphous atorvastatin |
SI20848A (en) | 2001-03-14 | 2002-10-31 | Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. | Pharmaceutical formulation containing atorvastatin calcium |
CA2450111C (en) * | 2001-06-29 | 2006-02-07 | Warner-Lambert Company Llc | Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin) |
EP1414796A1 (en) * | 2001-07-30 | 2004-05-06 | Dr. Reddy's Laboratories Ltd. | Crystalline forms vi and vii of atorvastatin calcium |
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