CA2627166A1 - Arthroplasty revision device and method - Google Patents
Arthroplasty revision device and method Download PDFInfo
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- CA2627166A1 CA2627166A1 CA002627166A CA2627166A CA2627166A1 CA 2627166 A1 CA2627166 A1 CA 2627166A1 CA 002627166 A CA002627166 A CA 002627166A CA 2627166 A CA2627166 A CA 2627166A CA 2627166 A1 CA2627166 A1 CA 2627166A1
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- tip
- tips
- surgical instrument
- tines
- forceps
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2/4611—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof of spinal prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/02—Surgical instruments, devices or methods, e.g. tourniquets for holding wounds open; Tractors
- A61B17/025—Joint distractors
- A61B2017/0256—Joint distractors for the spine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30331—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementarily-shaped recess, e.g. held by friction fit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30476—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements locked by an additional locking mechanism
- A61F2002/305—Snap connection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30518—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements with possibility of relative movement between the prosthetic parts
- A61F2002/3052—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements with possibility of relative movement between the prosthetic parts unrestrained in only one direction, e.g. moving unidirectionally
- A61F2002/30522—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements with possibility of relative movement between the prosthetic parts unrestrained in only one direction, e.g. moving unidirectionally releasable, e.g. using a releasable ratchet
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30604—Special structural features of bone or joint prostheses not otherwise provided for modular
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
- A61F2002/3069—Revision endoprostheses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
- A61F2/4425—Intervertebral or spinal discs, e.g. resilient made of articulated components
- A61F2002/443—Intervertebral or spinal discs, e.g. resilient made of articulated components having two transversal endplates and at least one intermediate component
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2002/4619—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof for extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2002/4622—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof having the shape of a forceps or a clamp
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2002/4625—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use
- A61F2002/4628—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use with linear motion along or rotating motion about an axis transverse to the instrument axis or to the implantation direction, e.g. clamping
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
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- A—HUMAN NECESSITIES
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- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0033—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
Abstract
A surgical instrument for revising/removing an artificial disc or removing/replacing a core of an artificial disc includes a pair of tips (12, 14), each tip having a pair of tines (16, 18, 20, 22) and a stop (24, 26, 28, 30) defining a proximal end of each tine. The stop of at least one tip is abutted against an interior surface of an implanted endplate of an artificial disc, whereby tines of the tip can support the artificial disc. The tip is separated from another, opposing tip, whereby opposing implanted endplates, each of which is supported by pairs of tines of a tip, are separated, thereby distracting vertebrae between which the endplates are implanted. Upon distracting the disc space, the core can be revised or removed from between the endplates of the artificial disc. Following core removal, the endplates of the artificial disc are revised (repositioned), removed or replaced.
Description
ARTHROPLASTY REVISION DEVICE AND METHOD
RELATED APPLICATION
This application is a continuation of and claims priority to U.S. Application No. 11/263,603, filed on October 31, 2005. The entire teachings of the above application is incorporated herein by reference.
BACKGROUND OF THE INVENTION
Arthroplasty is becoming significantly more prevalent as a surgical procedure to treat injury and disease. Of particular importance is the use of artificial discs to replace vertebral discs as functioning artificial joints.
Instrumentation employed to conduct surgical techniques that implant artificial discs still are of limited variety and generally do not permit modification subsequent to completion of the procedure without radical reconstruction and a significant likelihood of additional tissue damage. Artificial discs typically include two endplates and a core between endplates. The core pernlits movement of the endplates relative to each other, thereby simulating the function of the intervertebral disc that it replaces. Artificial discs can be implanted as complete assemblies, or, alternatively, endplates of an artificial disc can be inserted first, followed by placement of a core between the endplates. As in any surgical implantation, the initial placement may not be optimal. In such an instance, the surgeon typically is left with the option of leaving the implant in a sub-optimal position or removing it, and replacing the implant in a more optimal position. During the process, further traumatization of the surrounding tissue can occur. Therefore, a need exists for a device and a method that'significantly eliminates or reduces the above-referenced problems.
RELATED APPLICATION
This application is a continuation of and claims priority to U.S. Application No. 11/263,603, filed on October 31, 2005. The entire teachings of the above application is incorporated herein by reference.
BACKGROUND OF THE INVENTION
Arthroplasty is becoming significantly more prevalent as a surgical procedure to treat injury and disease. Of particular importance is the use of artificial discs to replace vertebral discs as functioning artificial joints.
Instrumentation employed to conduct surgical techniques that implant artificial discs still are of limited variety and generally do not permit modification subsequent to completion of the procedure without radical reconstruction and a significant likelihood of additional tissue damage. Artificial discs typically include two endplates and a core between endplates. The core pernlits movement of the endplates relative to each other, thereby simulating the function of the intervertebral disc that it replaces. Artificial discs can be implanted as complete assemblies, or, alternatively, endplates of an artificial disc can be inserted first, followed by placement of a core between the endplates. As in any surgical implantation, the initial placement may not be optimal. In such an instance, the surgeon typically is left with the option of leaving the implant in a sub-optimal position or removing it, and replacing the implant in a more optimal position. During the process, further traumatization of the surrounding tissue can occur. Therefore, a need exists for a device and a method that'significantly eliminates or reduces the above-referenced problems.
SUMMARY OF THE INVENTION
The invention is directed to a surgical instrument and a method for revising/removing an artificial disc or removing/replacing a core of an artificial disc.
In one embodiment, a surgical instrument of the invention includes a pair of tips, each tip having a pair of tines and a stop defining a proximal end of each tine.
In one embodiment, the stop of each tip extends between the tines of the tip.
The tines of each tip also can essentially match the tines of the other tip. In one embodiment, the tines of each tip have a flat surface, and the flat surface of the tines of each tip are parallel. Alternatively, the tines of each tip can have surfaces that complement surfaces of the tines of the other tip. In one such embodiment, each tip includes a base portion, wherein the tines of each tip extend from the base portion.
Also, the base portion of each tip can include a surface, at least a portion of which complements at least a portion of a surface of a base portion of the other tip. In one embodiment, the complementary surfaces of the base portion are continuous with the complementary surface of at least one tine of each tip. The continuous complementing surfaces of the tips can partition the remaining portion of the base of each tip when the complementary surfaces of the tips are in contact with each other.
In one embodiment, the surgical instrument includes a forceps portion. In one embodiment, the forceps portion is a double-action forceps. In another embodiment, the forceps portion is a parallel-action forceps. The tips can be releasable from the forceps portion. In one embodiment, at least one of the tips is releasable by activation of a spring-loaded clip that releasably couples the tip to the forceps portion. In a specific einbodiment, a major axis of the tines extends at an oblique angle to a major axis of the forceps portion. The base of at least one of the tips can define a chamfered recess having a major axis essentially parallel to a major axis of the tines of the tip. In a specific embodiment, botli tips can define a chamfered recess, wherein the chamfered recesses are opposed to each other when the tips are coupled to the forceps portion. In a particular embodiment, the continuous step of at least one tip is chainfered.
A method of revising a position of an artificial disc or of implanting a core of an artificial disc includes abutting the stop of at least one tip against an outer surface of an implanted endplate of the artificial disc, whereby tines of the tip can support the artificial disc. The tip is then separated from another, opposing tip, whereby opposing implanted endplates, each of which is supported by a pair of tines of a tip, are separated, thereby distracting vertebrae between which the endplates are implanted. The core between the endplates can then be removed and replaced by one that is more appropriately sized (e.g., height of the core), or the core can be removed so that the endplates can be removed and easily repositioned (revised) or replaced. In a specific embodiment, the stops of each pair of tips abuts each of a pair of opposing implanted endplates. In one embodiment, the tips are abutted against the endplates simultaneously. The tips can be abutted against the endplates while the tips are in a nested position. In one embodiment, the tips are separated from each other by actuating nonparallel-action forceps to which the tips are attached or of which they are a component. In another embodiment, the tips are separated from each other by actuating a parallel-action forceps to wliich the tips are attached or of which they are a component. The method can further include the step of releasing the forceps, whereby the endplates each rest against the core.
The present invention has many advantages. For example, the apparatus and method of the invention permit revision or implantation of a core of an artificial disc without disturbing seating of implanted endplates of the artificial disc.
Accordingly, the surgeon can conduct any necessary iterative procedure that may be required to optimally place a core between implanted endplates of an artificial disc.
Further, implanted endplates can be distracted with minimal movement, thereby also minimizing trauma to adjacent tissue. Also, abutting stops of the tines of each tip against an endplate enables the apparatus to be freely manipulated by the surgeon without significant risk of injury by incidental contact of the tines, such as by contact of the tines to nerve tissue.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 A is a perspective view of a pair of tips of a surgical instrument of the invention.
FIG. 1B is an end view of the pair of tips shown in FIG. 1A.
FIG. 1C is an opposing end view of the pair of tips shown in FIG. lA:
FIG. 2A is a perspective view of FIGS. 1A - 1C in a nearly-nested position.
The invention is directed to a surgical instrument and a method for revising/removing an artificial disc or removing/replacing a core of an artificial disc.
In one embodiment, a surgical instrument of the invention includes a pair of tips, each tip having a pair of tines and a stop defining a proximal end of each tine.
In one embodiment, the stop of each tip extends between the tines of the tip.
The tines of each tip also can essentially match the tines of the other tip. In one embodiment, the tines of each tip have a flat surface, and the flat surface of the tines of each tip are parallel. Alternatively, the tines of each tip can have surfaces that complement surfaces of the tines of the other tip. In one such embodiment, each tip includes a base portion, wherein the tines of each tip extend from the base portion.
Also, the base portion of each tip can include a surface, at least a portion of which complements at least a portion of a surface of a base portion of the other tip. In one embodiment, the complementary surfaces of the base portion are continuous with the complementary surface of at least one tine of each tip. The continuous complementing surfaces of the tips can partition the remaining portion of the base of each tip when the complementary surfaces of the tips are in contact with each other.
In one embodiment, the surgical instrument includes a forceps portion. In one embodiment, the forceps portion is a double-action forceps. In another embodiment, the forceps portion is a parallel-action forceps. The tips can be releasable from the forceps portion. In one embodiment, at least one of the tips is releasable by activation of a spring-loaded clip that releasably couples the tip to the forceps portion. In a specific einbodiment, a major axis of the tines extends at an oblique angle to a major axis of the forceps portion. The base of at least one of the tips can define a chamfered recess having a major axis essentially parallel to a major axis of the tines of the tip. In a specific embodiment, botli tips can define a chamfered recess, wherein the chamfered recesses are opposed to each other when the tips are coupled to the forceps portion. In a particular embodiment, the continuous step of at least one tip is chainfered.
A method of revising a position of an artificial disc or of implanting a core of an artificial disc includes abutting the stop of at least one tip against an outer surface of an implanted endplate of the artificial disc, whereby tines of the tip can support the artificial disc. The tip is then separated from another, opposing tip, whereby opposing implanted endplates, each of which is supported by a pair of tines of a tip, are separated, thereby distracting vertebrae between which the endplates are implanted. The core between the endplates can then be removed and replaced by one that is more appropriately sized (e.g., height of the core), or the core can be removed so that the endplates can be removed and easily repositioned (revised) or replaced. In a specific embodiment, the stops of each pair of tips abuts each of a pair of opposing implanted endplates. In one embodiment, the tips are abutted against the endplates simultaneously. The tips can be abutted against the endplates while the tips are in a nested position. In one embodiment, the tips are separated from each other by actuating nonparallel-action forceps to which the tips are attached or of which they are a component. In another embodiment, the tips are separated from each other by actuating a parallel-action forceps to wliich the tips are attached or of which they are a component. The method can further include the step of releasing the forceps, whereby the endplates each rest against the core.
The present invention has many advantages. For example, the apparatus and method of the invention permit revision or implantation of a core of an artificial disc without disturbing seating of implanted endplates of the artificial disc.
Accordingly, the surgeon can conduct any necessary iterative procedure that may be required to optimally place a core between implanted endplates of an artificial disc.
Further, implanted endplates can be distracted with minimal movement, thereby also minimizing trauma to adjacent tissue. Also, abutting stops of the tines of each tip against an endplate enables the apparatus to be freely manipulated by the surgeon without significant risk of injury by incidental contact of the tines, such as by contact of the tines to nerve tissue.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 A is a perspective view of a pair of tips of a surgical instrument of the invention.
FIG. 1B is an end view of the pair of tips shown in FIG. 1A.
FIG. 1C is an opposing end view of the pair of tips shown in FIG. lA:
FIG. 2A is a perspective view of FIGS. 1A - 1C in a nearly-nested position.
FIG. 2B is an end view of the pair of tips in the nearly-nested position shown in FIG. 2A.
FIG. 2C is a detail of the end view of FIG. 2B, showing the tines of the pair of tips nearly nested.
FIG. 2D is an opposing end view of the pair of tips shown in FIG. 2A in the nearly-nested position.
FIG. 2E is an alternative embodiment of the surgical instrument of the invention wherein the pair of tips abut each other at flat surfaces.
FIG. 3A is a perspective view of the pair of tips of FIGS. 1A - 1 C and 2A -2D in combination with a parallel-action forceps in a retraction position and of the relation of the pair of tips to the parallel-action forceps upon assembly.
FIG. 3B is a side view of the embodiment shown in FIG. 3A.
FIG. 3C is a perspective view of the embodiment of FIGS. 3A and 3B in a distracted position.
FIG. 3D is a side view of the embodiment of FIG. 3C in the distracted position.
FIG. 3E is a plan view of the embodiment of FIG. 3C.
FIG. 3F is an end view of the embodiment of FIG. 3C.
FIG. 4 is a perspective view of the pair of tips of FIGS. lA - 1C and 2A - 2D
in combination with a nonparallel-action forceps in a retraction position.
FIG. 5A is a perspective view of the invention in a retracted position where tips are non-modular components of parallel action forceps.
FIG. 5B is a side view of the embodiment shown in FIG. 5A.
FIG. 5C is an end view of the embodiment shown in FIG. 5A.
FIG. 5D is a perspective view of the embodiment of FIG. 5A in a distracted position.
FIG. 5E is a side view of the embodiment of FIG. 5D.
FIG. 5F is an end view of the embodiment of FIG. 5D.
DETAILED DESCRIPTION OF THE INVENTION
The foregoing and other objects, features and advantages of the invention will be apparent from the following more particular description of preferred embodiments of the invention, as illustrated in the accompanying drawings in which like reference characters refer to the same parts throughout the different views. The drawings are not necessarily to scale, emphasis instead being placed upon illustrating the principles of the invention.
The invention generally is directed to a surgical instrument and method for revising the position of, or implanting a core between, implanted endplates of an artificial disc. FIGS. 1A, 1B and 1C represent perspective and opposing end views of pair of tips 10 of the surgical instrument of the invention in a distracted position.
Tip 12 and opposing tip 14 include pairs of tines 16, 18 and 20, 22, respectively.
Tines 16, 18 of tip 12 and tines 20, 22 of opposing tip 14 are each defined by stops 24, 26 and stops 28, 30, respectively.
Tip 12 and opposing tip 14 include base 32 and base 34, respectively. As shown in FIG. 1A, stops 24, 26 of tip 12 are continuous along base 32. In corresponding manner, stops 28, 30 define a continuous surface along base 34 of opposing tip 14. Tines 16, 18 of tip 12 and tines 20, 22 of opposing tip 14, along with a portion of base 32 and base 34, defme complementary surfaces 36, 38 of tip 12, and complementary surfaces 40, 42 of opposing tip 14. Specifically, complementary surface 36 nests with complementary surface 40 and complementary surface 38 nests with complementary surface 42. As shown in FIG. 1B, tip 12 and opposing tip 14 also include chamfered surfaces 43, 44, at base 32 and base 34, respectively. As shown in FIG. 1 C, tips 12, 14 also include recessed portions 46, 48, which define chamfered recesses 50, 52, respectively. Chamfered recesses 50, 52 oppose each other when complementary surfaces 36, 40 and 38, 42 are nested.
Chamfered recesses 50, 52 each include a major axis that is essentially parallel to a plane extending through at least one tine of a respective tip. Chamfered recesses 50, 52 are intended to allow access to space between tines during core removal/replacement.
Modular connectors 54, 56 extend from base 32 and base 34, respectively. A
major axis of each of modular connectors 54, 56 extends through a major axis of at least one tine and a respective tip at an oblique angle. Preferably, the oblique angle is in a range of between about 1 degree and about 20 degrees. In a particularly preferred embodiment, the oblique angle is 15 degrees. In the alternative, a major axis of the tines is parallel to the major axis of the forceps, or distraction instrument.
FIGS. 2A, 2B and 2D represent perspective and opposing end views of the surgical instrument of the invention shown in FIGS. 1 A - 1 C in a nearly-nested or nearly-reduced position. Tip 12 and opposing tip 14 are nearly-nested, because, as can be seen in FIG. 2C, which is a detail of FIG. 2B, coinplementary surfaces 38, 42 of tines 18, 22, respectively, are not in contact, but are in close proximate relation to each other. Upon contact, tip 12 and opposing tip 14 would be in a nested position.
It is to be understood, however, that as an alternative to complementary surfaces, tines of opposing tips can abut without being complementary. In one embodiment, the tines of opposing tips can abut in a retracted position at continuous flat surfaces of the tines, as shown in FIG. 2E (in a distracted position).
FIGS. 3A and 3B represent, respectively, perspective and side views of surgical instrument 60 of the invention that includes parallel-action forceps 62 in combination with tip 12 and opposing tip 14 of FIGS. 1A - 1C and FIGS. 2A -2D.
Parallel-action forceps 62 can be any suitable parallel-action forceps, such as is described in U.S. 5,122,130, issued to Keller on June 16, 1992, the entire teachings of which are incorporated herein by reference. Tips 12 and 14 can be modular, wllereby they are releasable from another component of a surgical instrument.
As shown in FIGS. 3A and 3B, tip 12 and opposing tip 14 are compatible for coupling with parallel-action forceps 62 at modular connectors 54, 56. Modular connectors link with the parallel-action forceps with spring-loaded clips 64, 66, respectively. It is to be understood, however, that any suitable coupling mechanism could be employed, such as described in U.S. Serial Number 10/616,506, filed July 8, 2003, and U.S. Serial Number 10/959,598, filed October 6, 2004, the entire teachings of both of which are incorporated herein by reference. FIGS. 3A and 3B represent surgical instrument 60 in a reduced position. FIGS. 3C, 3D, 3E and 3F
represent surgical instrument 60 in a distracted position, with tip 12 and opposing tip assembled with parallel-action forceps 62. Alternatively, tip 12 and opposing tip 14 can be a component of or suitably connected such as by a modular connection as described, for example, above, to a nonparallel-action forceps as opposed to a parallel-action forceps. A representative example of a nonparallel-action forceps is shown in FIG. 4, wherein surgical instrument 70 includes nonparallel-action forceps 72 coupled to tip 12 and opposing tip 14. In another embodiment, tip 12 and tip 14 can be non-modular components of parallel action or non-parallel action forceps.
FIG. 5A is a perspective view of tip 12 and tip 14 as components of parallel action forceps 80 arranged as a non-modular embodiment in a retracted position. FIGS.
5B and 5C are side and end views, respectively, of the non-modular embodiment of FIG. 5A. FIGS. 5D, 5E and 5F are perspective, side and end views, respectively, of the embodiment of FIG. 5A in a distracted position.
In a method of the invention, the size of a core of an artificial disc is revised, or the core of an artificial disc is implanted, by abutting the stop or stops of at least one tip of the invention against an interior surface of an implanted endplate of an artificial disc, whereby tines of the tip can support the artificial disc. The tip is separated from another opposing tip, whereby opposing implanted endplates, each of which is supported by pairs of tines of a tip, are separated, thereby distracting vertebrae between which the endplates are implanted. Preferably, the stops and the tines of each tip comport with each endplate, whereby the force of distraction of the vertebrae is born, at least substantially, if not entirely, by the endplates, rather than by the force of direct contact between the vertebrae and the tines. Upon sufficient distraction of the vertebrae, the core between the artificial disc can be revised or the core can be removed, implanted, or both, between the endplates of the artificial disc.
Preferably, the tips are abutted against the endplates while the tips are in a nested position. Actuation of the nonparallel-action forceps or parallel-action forceps moves the forceps from a reduced position, such as in shown in FIGS. 3A and 3B, in the case of parallel-action forceps, to a distracted position, such as is shown in FIGS.
3C through 3F, thereby distracting vertebrae adjacent to implanted endplates of an artificial disc. In another embodiment of the method of the invention, the core can be removed, followed by removal of the pair of tips from between the endplates, and revision (repositioning), removal and/or replacement of the endplates of the artificial disc. The endplates can then be distracted again by use of the pair of tips, as described above, and a core, of either the same or a different size can be implanted between the endplates. The pair of tips is then removed by releasing the forceps, and the operation is completed..
FIG. 2C is a detail of the end view of FIG. 2B, showing the tines of the pair of tips nearly nested.
FIG. 2D is an opposing end view of the pair of tips shown in FIG. 2A in the nearly-nested position.
FIG. 2E is an alternative embodiment of the surgical instrument of the invention wherein the pair of tips abut each other at flat surfaces.
FIG. 3A is a perspective view of the pair of tips of FIGS. 1A - 1 C and 2A -2D in combination with a parallel-action forceps in a retraction position and of the relation of the pair of tips to the parallel-action forceps upon assembly.
FIG. 3B is a side view of the embodiment shown in FIG. 3A.
FIG. 3C is a perspective view of the embodiment of FIGS. 3A and 3B in a distracted position.
FIG. 3D is a side view of the embodiment of FIG. 3C in the distracted position.
FIG. 3E is a plan view of the embodiment of FIG. 3C.
FIG. 3F is an end view of the embodiment of FIG. 3C.
FIG. 4 is a perspective view of the pair of tips of FIGS. lA - 1C and 2A - 2D
in combination with a nonparallel-action forceps in a retraction position.
FIG. 5A is a perspective view of the invention in a retracted position where tips are non-modular components of parallel action forceps.
FIG. 5B is a side view of the embodiment shown in FIG. 5A.
FIG. 5C is an end view of the embodiment shown in FIG. 5A.
FIG. 5D is a perspective view of the embodiment of FIG. 5A in a distracted position.
FIG. 5E is a side view of the embodiment of FIG. 5D.
FIG. 5F is an end view of the embodiment of FIG. 5D.
DETAILED DESCRIPTION OF THE INVENTION
The foregoing and other objects, features and advantages of the invention will be apparent from the following more particular description of preferred embodiments of the invention, as illustrated in the accompanying drawings in which like reference characters refer to the same parts throughout the different views. The drawings are not necessarily to scale, emphasis instead being placed upon illustrating the principles of the invention.
The invention generally is directed to a surgical instrument and method for revising the position of, or implanting a core between, implanted endplates of an artificial disc. FIGS. 1A, 1B and 1C represent perspective and opposing end views of pair of tips 10 of the surgical instrument of the invention in a distracted position.
Tip 12 and opposing tip 14 include pairs of tines 16, 18 and 20, 22, respectively.
Tines 16, 18 of tip 12 and tines 20, 22 of opposing tip 14 are each defined by stops 24, 26 and stops 28, 30, respectively.
Tip 12 and opposing tip 14 include base 32 and base 34, respectively. As shown in FIG. 1A, stops 24, 26 of tip 12 are continuous along base 32. In corresponding manner, stops 28, 30 define a continuous surface along base 34 of opposing tip 14. Tines 16, 18 of tip 12 and tines 20, 22 of opposing tip 14, along with a portion of base 32 and base 34, defme complementary surfaces 36, 38 of tip 12, and complementary surfaces 40, 42 of opposing tip 14. Specifically, complementary surface 36 nests with complementary surface 40 and complementary surface 38 nests with complementary surface 42. As shown in FIG. 1B, tip 12 and opposing tip 14 also include chamfered surfaces 43, 44, at base 32 and base 34, respectively. As shown in FIG. 1 C, tips 12, 14 also include recessed portions 46, 48, which define chamfered recesses 50, 52, respectively. Chamfered recesses 50, 52 oppose each other when complementary surfaces 36, 40 and 38, 42 are nested.
Chamfered recesses 50, 52 each include a major axis that is essentially parallel to a plane extending through at least one tine of a respective tip. Chamfered recesses 50, 52 are intended to allow access to space between tines during core removal/replacement.
Modular connectors 54, 56 extend from base 32 and base 34, respectively. A
major axis of each of modular connectors 54, 56 extends through a major axis of at least one tine and a respective tip at an oblique angle. Preferably, the oblique angle is in a range of between about 1 degree and about 20 degrees. In a particularly preferred embodiment, the oblique angle is 15 degrees. In the alternative, a major axis of the tines is parallel to the major axis of the forceps, or distraction instrument.
FIGS. 2A, 2B and 2D represent perspective and opposing end views of the surgical instrument of the invention shown in FIGS. 1 A - 1 C in a nearly-nested or nearly-reduced position. Tip 12 and opposing tip 14 are nearly-nested, because, as can be seen in FIG. 2C, which is a detail of FIG. 2B, coinplementary surfaces 38, 42 of tines 18, 22, respectively, are not in contact, but are in close proximate relation to each other. Upon contact, tip 12 and opposing tip 14 would be in a nested position.
It is to be understood, however, that as an alternative to complementary surfaces, tines of opposing tips can abut without being complementary. In one embodiment, the tines of opposing tips can abut in a retracted position at continuous flat surfaces of the tines, as shown in FIG. 2E (in a distracted position).
FIGS. 3A and 3B represent, respectively, perspective and side views of surgical instrument 60 of the invention that includes parallel-action forceps 62 in combination with tip 12 and opposing tip 14 of FIGS. 1A - 1C and FIGS. 2A -2D.
Parallel-action forceps 62 can be any suitable parallel-action forceps, such as is described in U.S. 5,122,130, issued to Keller on June 16, 1992, the entire teachings of which are incorporated herein by reference. Tips 12 and 14 can be modular, wllereby they are releasable from another component of a surgical instrument.
As shown in FIGS. 3A and 3B, tip 12 and opposing tip 14 are compatible for coupling with parallel-action forceps 62 at modular connectors 54, 56. Modular connectors link with the parallel-action forceps with spring-loaded clips 64, 66, respectively. It is to be understood, however, that any suitable coupling mechanism could be employed, such as described in U.S. Serial Number 10/616,506, filed July 8, 2003, and U.S. Serial Number 10/959,598, filed October 6, 2004, the entire teachings of both of which are incorporated herein by reference. FIGS. 3A and 3B represent surgical instrument 60 in a reduced position. FIGS. 3C, 3D, 3E and 3F
represent surgical instrument 60 in a distracted position, with tip 12 and opposing tip assembled with parallel-action forceps 62. Alternatively, tip 12 and opposing tip 14 can be a component of or suitably connected such as by a modular connection as described, for example, above, to a nonparallel-action forceps as opposed to a parallel-action forceps. A representative example of a nonparallel-action forceps is shown in FIG. 4, wherein surgical instrument 70 includes nonparallel-action forceps 72 coupled to tip 12 and opposing tip 14. In another embodiment, tip 12 and tip 14 can be non-modular components of parallel action or non-parallel action forceps.
FIG. 5A is a perspective view of tip 12 and tip 14 as components of parallel action forceps 80 arranged as a non-modular embodiment in a retracted position. FIGS.
5B and 5C are side and end views, respectively, of the non-modular embodiment of FIG. 5A. FIGS. 5D, 5E and 5F are perspective, side and end views, respectively, of the embodiment of FIG. 5A in a distracted position.
In a method of the invention, the size of a core of an artificial disc is revised, or the core of an artificial disc is implanted, by abutting the stop or stops of at least one tip of the invention against an interior surface of an implanted endplate of an artificial disc, whereby tines of the tip can support the artificial disc. The tip is separated from another opposing tip, whereby opposing implanted endplates, each of which is supported by pairs of tines of a tip, are separated, thereby distracting vertebrae between which the endplates are implanted. Preferably, the stops and the tines of each tip comport with each endplate, whereby the force of distraction of the vertebrae is born, at least substantially, if not entirely, by the endplates, rather than by the force of direct contact between the vertebrae and the tines. Upon sufficient distraction of the vertebrae, the core between the artificial disc can be revised or the core can be removed, implanted, or both, between the endplates of the artificial disc.
Preferably, the tips are abutted against the endplates while the tips are in a nested position. Actuation of the nonparallel-action forceps or parallel-action forceps moves the forceps from a reduced position, such as in shown in FIGS. 3A and 3B, in the case of parallel-action forceps, to a distracted position, such as is shown in FIGS.
3C through 3F, thereby distracting vertebrae adjacent to implanted endplates of an artificial disc. In another embodiment of the method of the invention, the core can be removed, followed by removal of the pair of tips from between the endplates, and revision (repositioning), removal and/or replacement of the endplates of the artificial disc. The endplates can then be distracted again by use of the pair of tips, as described above, and a core, of either the same or a different size can be implanted between the endplates. The pair of tips is then removed by releasing the forceps, and the operation is completed..
While this invention has been particularly shown and described with reference to various embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the invention encompassed by the appended claims.
Claims (29)
1. A surgical instrument, comprising a pair of tips, each tip having a pair of tines and a stop defining a proximal end of each tine.
2. The surgical instrument of Claim 1, wherein the stop of each tip extends between the tine of the tip.
3. The surgical instrument of Claim 2, wherein the tines of each tip essentially match the tines of the other tip.
4. The surgical instrument of Claim 3, wherein the tines of each tip have a flat surface, and wherein the flat surfaces of the tines of each tip are parallel.
5. The surgical instrument of Claim 3, wherein the tines of each tip have surfaces that complement surfaces of the tines of the other tip.
6. The surgical instrument of Claim 5, wherein each tip includes a base portion, wherein the tines of each tip extend from the base portion.
7. The surgical instrument of Claim 6, wherein the base portion of each tip includes a surface, at least a portion of which complements at least a portion of a surface of a base portion of the other tip.
8. The surgical instrument of Claim 7, wherein the complementary surfaces of the base portion are continuous with the complementary surface of at least one tine of each tip.
9. The surgical instrument of Claim 8, wherein the continuous complementary surfaces of the tips partition the remaining portion of the base of each tip when the complementary surfaces of the tips are in contact with each other.
10. The surgical instrument of Claim 9, further including a forceps portion.
11. The surgical instrument of Claim 10, wherein the forceps portion is a nonparallel-action forceps.
12. The surgical instrument of Claim 10, wherein the forceps portion is a parallel-action forceps.
13. The surgical instrument of Claim 12, wherein at least one of the tips is releasable from the forceps portion.
14. The surgical instrument of Claim 13, wherein at least one of the tips is releasable by actuation of a spring-loaded clip that releasably couples the tip to the forceps portion.
15. The surgical instrument of Claim 14, wherein a major axis of the tines extends at an oblique angle to a major axis of the forceps portion.
16. The surgical instrument of Claim 15, wherein the base of at least one of the tips defines a chamfered recess having a major axis essentially parallel to a major axis of the tines of the clip.
17. The surgical instrument of Claim 16, wherein both tips define a chamfered recess, and wherein the chamfered recesses are opposed to each other when the tips are coupled to the forceps portion.
18. The surgical instrument of Claim 17, wherein the continuous stop of at least one tip includes a chamfered surface.
19. A method for manipulating an artificial disc, comprising the steps of :
a) abutting the stop of at least one tip against an outer surface of an implanted endplate of the artificial disc, whereby tines of the tip support the artificial disc; and b) separating the tip from another, opposing tip, whereby opposing implanted endplates, each of which is supported by a pair of tines of a tip, are separated, thereby distracting vertebrae between which the endplates are implanted, thereby manipulating the artificial disc.
a) abutting the stop of at least one tip against an outer surface of an implanted endplate of the artificial disc, whereby tines of the tip support the artificial disc; and b) separating the tip from another, opposing tip, whereby opposing implanted endplates, each of which is supported by a pair of tines of a tip, are separated, thereby distracting vertebrae between which the endplates are implanted, thereby manipulating the artificial disc.
20. The method of Claim 19, further including the step of removing or replacing a core of the artificial disc.
21. The method of Claim 20, wherein the core is removed, and further including the step of revising at least one of the endplates.
22. The method of Claim 21, wherein the core is removed and further including the step of replacing at least one of the endplates of the artificial disc.
23. The method of Claim 21, wherein the core is replaced with a core of different size.
24. The method of Claim 19, wherein the stop of each of a pair of tips abuts each of a pair of opposing implanted endplates.
25. The method of Claim 24, wherein the tips are abutted against the endplates simultaneously.
26. The method of Claim 25, wherein the tips are abutted against the endplate while the tips are in a nested position.
27. The method of Claim 26, wherein the tips are separated from each other by actuating a double-action forceps to which the tips are attached or of which they are a component.
28. The method of Claim 26, wherein the tips are separated from each other by actuating a parallel-action forceps to which the tips are attached or of which they are a component.
29. The method of Claim 28, further including the step of releasing the forceps, whereby the endplates each rest against the core.
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-
2005
- 2005-10-31 US US11/263,603 patent/US7867237B2/en active Active
-
2006
- 2006-10-25 WO PCT/US2006/041402 patent/WO2007053364A1/en active Application Filing
- 2006-10-25 JP JP2008537864A patent/JP2009513257A/en active Pending
- 2006-10-25 CA CA002627166A patent/CA2627166A1/en not_active Abandoned
- 2006-10-25 AU AU2006309102A patent/AU2006309102B2/en active Active
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WO2007053364A1 (en) | 2007-05-10 |
US20070100347A1 (en) | 2007-05-03 |
AU2006309102B2 (en) | 2010-08-19 |
AU2006309102A1 (en) | 2007-05-10 |
US20110040341A1 (en) | 2011-02-17 |
EP1942841A1 (en) | 2008-07-16 |
JP2009513257A (en) | 2009-04-02 |
EP1942841B1 (en) | 2014-07-23 |
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