CA2636711A1 - Flexible heart valve - Google Patents

Flexible heart valve Download PDF

Info

Publication number
CA2636711A1
CA2636711A1 CA002636711A CA2636711A CA2636711A1 CA 2636711 A1 CA2636711 A1 CA 2636711A1 CA 002636711 A CA002636711 A CA 002636711A CA 2636711 A CA2636711 A CA 2636711A CA 2636711 A1 CA2636711 A1 CA 2636711A1
Authority
CA
Canada
Prior art keywords
heart valve
stent
commissures
commissure
cusps
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002636711A
Other languages
French (fr)
Other versions
CA2636711C (en
Inventor
Alain Carpentier
Stefan G. Schreck
Richard S. Rhee
Diana Nguyen Thien Nhon
Hung Ly Lam
William Recktenwald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Edwards Lifesciences Corp
Original Assignee
Edwards Lifesciences Corporation
Alain Carpentier
Stefan G. Schreck
Richard S. Rhee
Diana Nguyen Thien Nhon
Hung Ly Lam
William Recktenwald
Baxter International Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/332,759 external-priority patent/US6558418B2/en
Application filed by Edwards Lifesciences Corporation, Alain Carpentier, Stefan G. Schreck, Richard S. Rhee, Diana Nguyen Thien Nhon, Hung Ly Lam, William Recktenwald, Baxter International Inc. filed Critical Edwards Lifesciences Corporation
Publication of CA2636711A1 publication Critical patent/CA2636711A1/en
Application granted granted Critical
Publication of CA2636711C publication Critical patent/CA2636711C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0066—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements stapled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004—Rounded shapes, e.g. with rounded corners
    • A61F2230/0013—Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0017—Angular shapes
    • A61F2230/0023—Angular shapes triangular
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/902—Method of implanting
    • Y10S623/904—Heart

Abstract

A highly flexible tissue-type heart valve is disclosed having a structural stent in a generally cylindrical configuration with cusps and commissures that are permitted to move radially. The stent commissures are constructed so that the cusps are pivotably or flexibly coupled together at the commissures to permit relative movement therebetween. The stent may be cloth-covered and may be a single element or may be made in three separate elements for a three cusp valve, each element having a cusp portion and two commissure portions; adjacent commissure portions for each pair of adjacent stent element combining to form the stent commissures. If the stent has separate elements their commissure portions may be pivotably or flexibly coupled, or may be designed to completely separate into independent leaflets at bioresorbable couples. The cloth covering may have an outwardly projecting flap that mates with valve leaflets (e.g., pericardial leaflets) along the cusps and commissures. A connecting band may be provided that follows the cusps and commissures and extends outwardly. The valve is connected to the natural tissue along the undulating connecting band using conventional techniques, such as sutures. The connecting band may be a cloth-covered silicon member and attaches to the underside of the valve at the cusps to provide support to the stent and to the outer side of the valve at the commissures. A multi-legged holder is used to implant the valve, with the legs serving to maintain an implant shape to the valve. The holder may have six legs with one releasably connected to each cusp and one releasably connected to each commissure. A method of implantation of the flexible valve using the holder is also disclosed.

Claims (79)

1. A prosthetic heart valve, comprising:
a flexible, generally cylindrical stent having alternating cusps and commissures;
a plurality of flexible leaflets attached to the stent so as to form a one-way valve within the cylinder, and a flexible band attached along the stent and having a free edge extending outward from the stent along the alternating cusps and commissures for connecting the heart valve to an anatomical orifice.
2. A highly flexible heart valve, comprising:
a stent/leaflet subassembly including a peripheral stent and a plurality of leaflets disposed therewithin, the stent/leaflet subassembly including alternating cusps and commissures; and a connecting band attached to the stent/leaflet subassembly and following the alternating cusps and commissures, the band having a free edge extending from the stent for connecting the heart valve to an anatomical orifice.
3. The heart valve of either of claims 1 or 2, wherein the stent is configured to permit the cusps and commissures to move radially in and out.
4. The heart valve of either of claims 1 or 2, wherein the stent comprises a cloth-covered rod-like structure.
5. The heart valve of claim 4, wherein the cloth-covering closely surrounds the rod-like structure and exhibits a flap projecting outward therefrom substantially the entire length of the cusps and commissures for connecting to the band and leaflets.
6. The heart valve of either of claims 1 or 2, wherein the stent comprises a plurality of separate elements, each having arcuate cusp regions and upstanding commissure regions, wherein each pair of commissure regions of adjacent elements are juxtaposed to define each commissure.
7. The heart valve of claim 6, wherein each pair of commissure regions of adjacent elements is coupled together to be relatively fixed at the commissures, while the intermediate cusps are permitted to move radially with respect to the commissures.
8. The heart valve of either of claims 1 or 2, wherein the band comprises a suture-permeable inner member and a cloth outer cover, the band exhibiting continuous cusp portions and commissure portions.
9. The heart valve of claim 8, wherein the suture-permeable inner member comprises a molded silicone structure.
10. The heart valve of claim 8, wherein the band comprises an outwardly projecting series of parallel ribs extending continuously along the entire band cusp portions and commissure portions.
11. The heart valve of claim 8, wherein the commissure portions of the band are generally planar and axially aligned, and the cusp portions of the band each include an outwardly angled portion and an inwardly angled ledge.
12. The heart valve of claim 11, wherein the inwardly angled ledge of each cusp portion of the band extends inward a distance sufficient to support the corresponding cusp.
13. The heart valve of either of claims 1 or 2, wherein the band includes arcuate cusp portions generally conforming to the cusps, and the band includes commissure portions therebetween each having an inverted U-shape to define a downwardly opening gap that enhances flexibility of the valve by permitting relative cusp movement.
14. A prosthetic heart valve, comprising:
a plurality of flexible leaflets each having an arcuate cusp edge and a coapting edge; and a stent including a plurality of cusps connected to each other at upstanding commissures to generally defined a substantially cylindrical volume therebetween, the leaflets being attached to the stent within the volume and the cusps being free to move with respect to one another about the commissures.
15. The heart valve of claim 14, wherein the stent comprises a plurality of separate members dispose generally in a circle to define the cylindrical volume, each member including an arcuate cusp portion and two upstanding commissure portions, wherein each pair of commissure portions of adjacent members is juxtaposed to define each stent commissure.
16. The heart valve of claim 14, wherein the cusps of the valve are hingedly connected to each other.
17. The heart valve of claim 16, wherein the stent comprises a single member and the cusps are hingedly connected to each other at coil springs.
18. The heart valve of claim 16, wherein the stent comprises a plurality of separate members dispose generally in a circle to define the cylindrical volume, each member including an arcuate cusp portion and two upstanding commissure portions, wherein each pair of commissure portions of adjacent members is juxtaposed to define each stent commissure.
19. The heart valve of claim 18, wherein each pair of commissure portions is connected with sutures to enable relative movement of adjacent cusp portions.
20. The heart valve of claim 18, wherein each commissure portion is connected to pivot about a first axis which is fixed with respect to a second axis about which the adjacent commissure portion pivots.
21. The heart valve of claim 20, wherein the first and second axes are coincident.
22. The heart valve of claim 21, wherein each commissure portion terminates at an arcuate tip, the valve further including coupling members having an arcuate channel therein, the coupling members receiving the arcuate tips of the commissure portions and permitting relative sliding movement about a pivot axis defined by the arcuate channel.
23. The heart valve of claim 20, wherein each commissure portion terminates at a generally circular tip, the valve further including coupling members having a pair of spaced pins provided thereon that defined the first and second axes and about which the circular tips of each commissure portion pivot.
24. The heart valve of claim 18, wherein the valve includes a plurality of pliable coupling members each of which couples to a pair of adjacent commissure portions to permit relative movement therebetween.
25. The heart valve of claim 24, wherein each commissure portion terminates at a generally linear tip, the pliable coupling members comprising pliable tubular sleeves closely fitting over the linear tips.
26. The heart valve of Claim 14, further including means for connecting the stent cusps together at the stent commissures to enable relative movement of adjacent cusps.
27. The heart valve of Claim 26, wherein the means for connecting the stent cusps together comprises sutures.
28. The heart valve of Claim 26, wherein the means for connecting the stent cusps together comprises a flexible material interface.
29. The heart valve of Claim 26, where the means for connecting the stent cusps together comprises a bioresorbable structure.
30. The heart valve of claim 14, wherein the stent comprises a cloth-covered rod-like structure.
31. The heart valve of claim 30, wherein the cloth-covering closely surrounds the rod-like structure and exhibits a flap projecting outward therefrom substantially the entire length of the cusps and commissures.
32. The heart valve of claim 31, wherein the flap has a width that varies along the cusps and commissures of the stent, the flap being narrower in the cusps.
33. The heart valve of claim 31, further including a flexible band attached along the stent flap and having a free edge extending outward from the stent along the alternating cusps and commissures for connecting the heart valve to an anatomical orifice.
34. The heart valve of claim 33, wherein the cusp edges of the leaflets are attached between the band and the stent flap.
35. The heart valve of claim 33, wherein the band exhibits continuous cusps and commissures, the cusps of the band each including an outwardly angled portion and an inwardly angled ledge extending inward a distance sufficient to support the corresponding cusp of the stent.
36. The heart valve of claim 30, wherein the rod-like structure is made of a polymer.
37. The heart valve of claim 22, wherein each separate member is separately cloth-covered.
38. The heart valve of claim 37, wherein each upstanding commissure portion terminates in a substantially circular bent tip, adjacent and bent tips of each separate member being juxtaposed and sutured together through the respective cloth coverings.
39. The heart valve of claim 18, wherein each leaflet includes an arcuate cusp edge terminating at outer tips joined to the stent commissures, and a coapting edge that is defined by two relatively angled lines joined at an apex midway between the two tips.
40. The heart valve of claim 39, wherein each leaflet is made of pericardial tissue.
41. The heart valve of claim 39, wherein the arcuate cusp edges gradually become asymptotic at the tips.
42. The heart valve of claim 39, further including an outwardly angled transition edge from the arcuate cusp edges to the tips.
43. The heart valve of claim 42, wherein a generally linear edge is defined between each outwardly angled transition edge and the corresponding tip defining a generally trapezoidal tab adjacent the tips.
44. The heart valve of claim 18, wherein each leaflet includes an arcuate cusp edge terminating at outer tips joined to the stent commissures, wherein adjacent tips are joined not to each other but to portions of the stent that are permitted to move with respect to one another.
45. The heart valve of claim 44, further including a flexible band attached along the stent and having a free edge extending outward from the stent along the alternating cusps and commissures for connecting the heart valve to an anatomical orifice, the band defining an inverted U-shape at the stent commissures with a gap formed between portions of the stent that are permitted to move with respect to one another.
46. A prosthetic heart valve, comprising:
a stent including a plurality of stent members adjacently disposed around a circle to define a substantially cylindrical volume therebetween, the stent including a plurality of alternating cusps and commissures.
47. The heart valve of claim 46, wherein each stent member includes an arcuate cusp region and two upstanding commissure regions, and wherein each pair of commissure regions of adjacent stent members is juxtaposed to define each stent commissure.
48. The heart valve of Claim 47, further including means for connecting the stent members together at the stent commissures to enable relative movement of adjacent cusp regions.
49. The heart valve of Claim 48, wherein the means for connecting the stent members together comprises sutures.
50. The heart valve of Claim 48, wherein the means for connecting the stent members together comprises a flexible material interface.
51. The heart valve of Claim 48, where the means for connecting the stent members together comprises a bioresorbable structure.
52. The heart valve of claim 47, wherein each commissure region is connected to pivot about a first axis which is fixed with respect to a second axis about which the adjacent commissure region pivots.
53. The heart valve of claim 52, wherein each commissure region terminates at a generally circular tip, the valve further including coupling members having a pair of spaced pins provided thereon that defined the first and second axes and about which the circular tips of each commissure region pivot.
54. The heart valve of claim 52, wherein the first and second axes are coincident.
55. The heart valve of claim 47, wherein each commissure region terminates at an arcuate tip, the valve further including coupling members having an arcuate channel therein, the coupling members receiving the arcuate tips of the commissure regions and permitting relative sliding movement about a pivot axis defined by the arcuate channel.
56. The heart valve of claim 47, wherein the valve includes a plurality of pliable coupling members each of which couples to a pair of adjacent commissure regions to permit relative movement therebetween.
57. The heart valve of claim 56, wherein each commissure region terminates at a generally linear tip, the pliable coupling members comprising pliable tubular sleeves closely fitting over the linear tips.
58. The heart valve of claim 46, wherein each stent member is coupled to move with respect to the other stent members about the stent commissures.
59. The heart valve of claim 58, wherein each stent member is pivotally coupled with respect to the other stent members at the stent commissures.
60. The heart valve of claim 58, wherein each stent member is flexibly coupled with respect to the other stent members at the stent commissures.
61. The heart valve of claim 60, wherein each stent member is elastically coupled with respect to the other stent members at the stent commissures.
62. A holder for a prosthetic heart valve, comprising:
a central hub with a plurality of radially outward upper legs, and a plurality of lower legs angled downward and outward, the upper legs being adapted to connect to corresponding commissures of a prosthetic heart valve, and the lower legs being adapted to connect to corresponding cusps of the prosthetic heart valve.
63. The holder of claim 62, wherein the hub is internally threaded for mating with a handle.
64. The holder of claim 62, wherein each of the upper and lower legs includes structure to which sutures can be anchored.
65. The holder of claim 62, wherein each lower leg has a width from the hub to a terminal end that is greatest at the terminal end to provide more surface area to contact the corresponding valve cusp.
66. A prosthetic heart valve and implantation holder combination, comprising:
a flexible prosthetic heart valve having alternating cusps and commissures in a generally cylindrical configuration and adapted to move radially in and out with respect to one another; and the rigid holder having structure for maintaining a fixed shape of the flexible prosthetic heart valve during implantation.
67. The combination of claim 66, wherein the holder includes a central hub with a plurality of radially outward upper legs, and a plurality of lower legs angled downward and outward, the upper legs being adapted to connect to corresponding commissures of the prosthetic heart valve, and the lower legs being adapted to connect to corresponding cusps of the prosthetic heart valve.
68. The combination of claim 67, wherein the hub is internally threaded for mating with a handle.
69. The combination of claim 66, structure on the holder for maintaining the fixed shape of the heart valve comprises a plurality of outwardly extending legs, the assembly further comprising a plurality of sutures attaching each leg to a portion on the heart valve.
70. The combination of claim 69, wherein each of the legs includes structure to which sutures can be anchored.
71. The combination of claim 69, wherein the holder includes one leg for each cusp and one leg for each commissure of the valve.
72. A heart valve leaflet, comprising:
a flexible, planar body having an arcuate cusp edge terminating at outer tips, and a coapting edge that is defined by two relatively angled lines joined at an apex directed away from the cusp edge midway between the two tips.
73. The heart valve of claim 72, wherein each leaflet is made of pericardial tissue.
74. The heart valve of claim 72, wherein the arcuate cusp edges gradually become asymptotic at the tips.
75. The heart valve of claim 72, further including an outwardly angled transition edge from the arcuate cusp edges to the tips.
76. The heart valve of claim 75, wherein a generally linear edge is defined between each outwardly angled transition edge and the corresponding tip defining a generalty trapezoidal tab adjacent the tips.
77. An independent heart valve leaflet, comprising:
a flexible body having an arcuate fixation edge defined by a cusp region and two commissure regions, and a coapting edge between the two commissure regions, and a flexible support attached along the fixation edge.
78. The leaflet of claim 77, wherein the flexible body is a biomaterial and the support comprises a strip of synthetic material.
79. The leaflet of claim 78, wherein the flexible body is made of bovine pericardium.
CA2636711A 1999-01-26 2000-01-26 Flexible heart valve Expired - Lifetime CA2636711C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11744599P 1999-01-26 1999-01-26
US60/117,445 1999-01-26
US09/332,759 US6558418B2 (en) 1999-01-26 1999-06-14 Flexible heart valve
CA002358521A CA2358521C (en) 1999-01-26 2000-01-26 Flexible heart valve

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002358521A Division CA2358521C (en) 1999-01-26 2000-01-26 Flexible heart valve

Publications (2)

Publication Number Publication Date
CA2636711A1 true CA2636711A1 (en) 2000-07-27
CA2636711C CA2636711C (en) 2011-11-22

Family

ID=26815300

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002358521A Expired - Lifetime CA2358521C (en) 1999-01-26 2000-01-26 Flexible heart valve
CA2636711A Expired - Lifetime CA2636711C (en) 1999-01-26 2000-01-26 Flexible heart valve

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002358521A Expired - Lifetime CA2358521C (en) 1999-01-26 2000-01-26 Flexible heart valve

Country Status (10)

Country Link
US (1) US6338740B1 (en)
EP (2) EP1143882B1 (en)
JP (3) JP4230118B2 (en)
AT (1) ATE379998T1 (en)
AU (1) AU757091B2 (en)
BR (1) BR0007745B1 (en)
CA (2) CA2358521C (en)
DE (1) DE60037309T2 (en)
IL (2) IL144298A0 (en)
WO (1) WO2000042950A2 (en)

Families Citing this family (258)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6332893B1 (en) 1997-12-17 2001-12-25 Myocor, Inc. Valve to myocardium tension members device and method
US6260552B1 (en) 1998-07-29 2001-07-17 Myocor, Inc. Transventricular implant tools and devices
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
US6736845B2 (en) * 1999-01-26 2004-05-18 Edwards Lifesciences Corporation Holder for flexible heart valve
US6371983B1 (en) * 1999-10-04 2002-04-16 Ernest Lane Bioprosthetic heart valve
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US7018406B2 (en) 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
US6458153B1 (en) 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US6872226B2 (en) 2001-01-29 2005-03-29 3F Therapeutics, Inc. Method of cutting material for use in implantable medical device
CN1404376A (en) 2000-01-27 2003-03-19 3F治疗有限公司 Prosthetic heart valve
ES2286097T7 (en) 2000-01-31 2009-11-05 Cook Biotech, Inc ENDOPROTESIS VALVES.
DE10010074B4 (en) 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device for fastening and anchoring heart valve prostheses
DE10010073B4 (en) * 2000-02-28 2005-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anchoring for implantable heart valve prostheses
US8474460B2 (en) 2000-03-04 2013-07-02 Pulmonx Corporation Implanted bronchial isolation devices and methods
US6454799B1 (en) * 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
US8784482B2 (en) * 2000-09-20 2014-07-22 Mvrx, Inc. Method of reshaping a heart valve annulus using an intravascular device
US7527646B2 (en) * 2000-09-20 2009-05-05 Ample Medical, Inc. Devices, systems, and methods for retaining a native heart valve leaflet
US8956407B2 (en) 2000-09-20 2015-02-17 Mvrx, Inc. Methods for reshaping a heart valve annulus using a tensioning implant
US20060106278A1 (en) * 2004-05-14 2006-05-18 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of an adjustable bridge implant system
US20050228422A1 (en) * 2002-11-26 2005-10-13 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US7691144B2 (en) 2003-10-01 2010-04-06 Mvrx, Inc. Devices, systems, and methods for reshaping a heart valve annulus
US20090287179A1 (en) 2003-10-01 2009-11-19 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US6893459B1 (en) * 2000-09-20 2005-05-17 Ample Medical, Inc. Heart valve annulus device and method of using same
WO2004030568A2 (en) * 2002-10-01 2004-04-15 Ample Medical, Inc. Device and method for repairing a native heart valve leaflet
US20060106279A1 (en) * 2004-05-14 2006-05-18 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of a bridge implant having an adjustable bridge stop
US20080091264A1 (en) 2002-11-26 2008-04-17 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US6461382B1 (en) * 2000-09-22 2002-10-08 Edwards Lifesciences Corporation Flexible heart valve having moveable commissures
US6616684B1 (en) 2000-10-06 2003-09-09 Myocor, Inc. Endovascular splinting devices and methods
US6723038B1 (en) 2000-10-06 2004-04-20 Myocor, Inc. Methods and devices for improving mitral valve function
US6974476B2 (en) * 2003-05-05 2005-12-13 Rex Medical, L.P. Percutaneous aortic valve
US6565599B1 (en) 2000-12-28 2003-05-20 Advanced Cardiovascular Systems, Inc. Hybrid stent
WO2002074201A1 (en) * 2001-03-16 2002-09-26 Mayo Foundation For Medical Education And Research Synthethic leaflets for heart valve repair or replacement
US7556646B2 (en) * 2001-09-13 2009-07-07 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
FR2828263B1 (en) 2001-08-03 2007-05-11 Philipp Bonhoeffer DEVICE FOR IMPLANTATION OF AN IMPLANT AND METHOD FOR IMPLANTATION OF THE DEVICE
US20030050648A1 (en) 2001-09-11 2003-03-13 Spiration, Inc. Removable lung reduction devices, systems, and methods
US6562069B2 (en) * 2001-09-19 2003-05-13 St. Jude Medical, Inc. Polymer leaflet designs for medical devices
EP1434542A2 (en) * 2001-10-01 2004-07-07 Ample Medical, Inc. Methods and devices for heart valve treatments
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
US6592594B2 (en) 2001-10-25 2003-07-15 Spiration, Inc. Bronchial obstruction device deployment system and method
US20030114919A1 (en) * 2001-12-10 2003-06-19 Mcquiston Jesse Polymeric stent with metallic rings
US7201771B2 (en) * 2001-12-27 2007-04-10 Arbor Surgical Technologies, Inc. Bioprosthetic heart valve
US7189258B2 (en) * 2002-01-02 2007-03-13 Medtronic, Inc. Heart valve system
US7033390B2 (en) * 2002-01-02 2006-04-25 Medtronic, Inc. Prosthetic heart valve system
US6764510B2 (en) 2002-01-09 2004-07-20 Myocor, Inc. Devices and methods for heart valve treatment
WO2003068108A1 (en) * 2002-02-14 2003-08-21 St. Jude Medical, Inc. Heart valve structures
GB0204381D0 (en) * 2002-02-26 2002-04-10 Mcminn Derek J W Knee prosthesis
US20030181922A1 (en) 2002-03-20 2003-09-25 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20030216769A1 (en) 2002-05-17 2003-11-20 Dillard David H. Removable anchored lung volume reduction devices and methods
US9694166B2 (en) 2002-03-26 2017-07-04 Medtronics Ps Medical, Inc. Method of draining cerebrospinal fluid
US7691461B1 (en) 2002-04-01 2010-04-06 Advanced Cardiovascular Systems, Inc. Hybrid stent and method of making
US8348963B2 (en) * 2002-07-03 2013-01-08 Hlt, Inc. Leaflet reinforcement for regurgitant valves
US7959674B2 (en) * 2002-07-16 2011-06-14 Medtronic, Inc. Suture locking assembly and method of use
WO2004010845A2 (en) 2002-07-26 2004-02-05 Emphasys Medical, Inc. Bronchial flow control devices with membrane seal
EP2517674B1 (en) * 2002-08-15 2016-03-16 Cook Medical Technologies LLC Implantable vascular device
CA2503258C (en) * 2002-08-28 2011-08-16 Heart Leaflet Technologies, Inc. Method and device for treating diseased valve
US7137184B2 (en) 2002-09-20 2006-11-21 Edwards Lifesciences Corporation Continuous heart valve support frame and method of manufacture
EP1562522B1 (en) * 2002-10-01 2008-12-31 Ample Medical, Inc. Devices and systems for reshaping a heart valve annulus
US7112219B2 (en) 2002-11-12 2006-09-26 Myocor, Inc. Devices and methods for heart valve treatment
US20040097979A1 (en) * 2002-11-14 2004-05-20 Oleg Svanidze Aortic valve implantation device
US7189259B2 (en) * 2002-11-26 2007-03-13 Clemson University Tissue material and process for bioprosthesis
US20040153145A1 (en) * 2002-11-26 2004-08-05 Clemson University Fixation method for bioprostheses
US8551162B2 (en) 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
US7455687B2 (en) * 2002-12-30 2008-11-25 Advanced Cardiovascular Systems, Inc. Polymer link hybrid stent
US9333102B2 (en) * 2003-02-24 2016-05-10 Allium Medical Solutions Ltd. Stent
US7717952B2 (en) * 2003-04-24 2010-05-18 Cook Incorporated Artificial prostheses with preferred geometries
US8221492B2 (en) * 2003-04-24 2012-07-17 Cook Medical Technologies Artificial valve prosthesis with improved flow dynamics
US7625399B2 (en) 2003-04-24 2009-12-01 Cook Incorporated Intralumenally-implantable frames
AU2004253375B2 (en) * 2003-07-08 2011-07-14 Ventor Technologies Ltd. Implantable prosthetic devices particularly for transarterial delivery in the treatment of aortic stenosis, and methods of implanting such devices
FR2858543B1 (en) * 2003-08-08 2006-02-03 Assist Publ Hopitaux De Paris AORTIC AND ANCILLARY RING FOR ITS INSTALLATION
US7533671B2 (en) 2003-08-08 2009-05-19 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US8021421B2 (en) 2003-08-22 2011-09-20 Medtronic, Inc. Prosthesis heart valve fixturing device
US7556647B2 (en) * 2003-10-08 2009-07-07 Arbor Surgical Technologies, Inc. Attachment device and methods of using the same
US20050149181A1 (en) * 2004-01-07 2005-07-07 Medtronic, Inc. Bileaflet prosthetic valve and method of manufacture
US7871435B2 (en) 2004-01-23 2011-01-18 Edwards Lifesciences Corporation Anatomically approximate prosthetic mitral heart valve
US20090132035A1 (en) * 2004-02-27 2009-05-21 Roth Alex T Prosthetic Heart Valves, Support Structures and Systems and Methods for Implanting the Same
US8128692B2 (en) * 2004-02-27 2012-03-06 Aortx, Inc. Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of same
US20070073387A1 (en) * 2004-02-27 2007-03-29 Forster David C Prosthetic Heart Valves, Support Structures And Systems And Methods For Implanting The Same
ITTO20040135A1 (en) 2004-03-03 2004-06-03 Sorin Biomedica Cardio Spa CARDIAC VALVE PROSTHESIS
US20050228494A1 (en) * 2004-03-29 2005-10-13 Salvador Marquez Controlled separation heart valve frame
JP5290573B2 (en) * 2004-04-23 2013-09-18 メドトロニック スリーエフ セラピューティクス，インコーポレイティド Implantable prosthetic valve
US7534259B2 (en) 2004-05-05 2009-05-19 Direct Flow Medical, Inc. Nonstented heart valves with formed in situ support
US7566343B2 (en) * 2004-09-02 2009-07-28 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
CA2583591C (en) * 2004-10-02 2018-10-30 Christoph Hans Huber Methods and devices for repair or replacement of heart valves or adjacent tissue without the need for full cardiopulmonary support
US7771472B2 (en) 2004-11-19 2010-08-10 Pulmonx Corporation Bronchial flow control devices and methods of use
DE102005003632A1 (en) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Catheter for the transvascular implantation of heart valve prostheses
US7670368B2 (en) * 2005-02-07 2010-03-02 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
ITTO20050074A1 (en) 2005-02-10 2006-08-11 Sorin Biomedica Cardio Srl CARDIAC VALVE PROSTHESIS
US8057538B2 (en) 2005-02-18 2011-11-15 Medtronic, Inc. Valve holder
CZ2007547A3 (en) * 2005-03-01 2007-10-24 Andrieu@Raymond IIntraparietal reinforcement device for biological prosthesis of heart and reinforced aortic valve biological prosthesis per se
US10219902B2 (en) 2005-03-25 2019-03-05 Mvrx, Inc. Devices, systems, and methods for reshaping a heart valve anulus, including the use of a bridge implant having an adjustable bridge stop
US8062359B2 (en) * 2005-04-06 2011-11-22 Edwards Lifesciences Corporation Highly flexible heart valve connecting band
US7513909B2 (en) * 2005-04-08 2009-04-07 Arbor Surgical Technologies, Inc. Two-piece prosthetic valves with snap-in connection and methods for use
EP1887980B1 (en) * 2005-05-17 2012-09-05 Cook Medical Technologies LLC Frameless valve prosthesis and system for its deployment
EP3482717B1 (en) 2005-05-27 2023-09-06 Edwards Lifesciences Corporation Stentless support structure
US8211169B2 (en) 2005-05-27 2012-07-03 Medtronic, Inc. Gasket with collar for prosthetic heart valves and methods for using them
US7739971B2 (en) * 2005-06-07 2010-06-22 Edwards Lifesciences Corporation Systems and methods for assembling components of a fabric-covered prosthetic heart valve
WO2006133294A2 (en) * 2005-06-07 2006-12-14 Direct Flow Medical, Inc. Stentless aortic valve replacement with high radial strength
EP1913899B1 (en) * 2005-07-08 2010-10-06 Beijing Balance Medical Co. Ltd. A valved patch and a valved tube for repairing a cardiac outflow vessel
US7455689B2 (en) * 2005-08-25 2008-11-25 Edwards Lifesciences Corporation Four-leaflet stented mitral heart valve
DE102005051849B4 (en) 2005-10-28 2010-01-21 JenaValve Technology Inc., Wilmington Device for implantation and attachment of heart valve prostheses
DE102005052628B4 (en) * 2005-11-04 2014-06-05 Jenavalve Technology Inc. Self-expanding, flexible wire mesh with integrated valvular prosthesis for the transvascular heart valve replacement and a system with such a device and a delivery catheter
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US7967857B2 (en) 2006-01-27 2011-06-28 Medtronic, Inc. Gasket with spring collar for prosthetic heart valves and methods for making and using them
US8147541B2 (en) * 2006-02-27 2012-04-03 Aortx, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
US8403981B2 (en) * 2006-02-27 2013-03-26 CardiacMC, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
JP5102279B2 (en) * 2006-03-10 2012-12-19 メドトロニック，インコーポレイテッド Artificial valve introducer, method for producing the same and method for using the same
US7691151B2 (en) 2006-03-31 2010-04-06 Spiration, Inc. Articulable Anchor
US7806926B2 (en) 2006-04-14 2010-10-05 Edwards Lifesciences Corporation Holders for prosthetic aortic heart valves
WO2007130881A2 (en) * 2006-04-29 2007-11-15 Arbor Surgical Technologies, Inc. Multiple component prosthetic heart valve assemblies and apparatus and methods for delivering them
US8585594B2 (en) * 2006-05-24 2013-11-19 Phoenix Biomedical, Inc. Methods of assessing inner surfaces of body lumens or organs
AU2007261016A1 (en) * 2006-06-20 2007-12-27 Aortx, Inc. Prosthetic valve implant site preparation techniques
AU2007260928A1 (en) * 2006-06-20 2007-12-27 Aortx, Inc. Prosthetic heart valves, support structures and systems and methods for implanting the same
EP2035723A4 (en) * 2006-06-20 2011-11-30 Aortx Inc Torque shaft and torque drive
AU2007260951A1 (en) * 2006-06-21 2007-12-27 Aortx, Inc. Prosthetic valve implantation systems
WO2008002767A1 (en) * 2006-06-29 2008-01-03 Mayo Foundation For Medical Education And Research Genetically modified heart valve xenografts
US7815676B2 (en) * 2006-07-07 2010-10-19 The Cleveland Clinic Foundation Apparatus and method for assisting in the removal of a cardiac valve
US20100256752A1 (en) * 2006-09-06 2010-10-07 Forster David C Prosthetic heart valves, support structures and systems and methods for implanting the same,
US7935144B2 (en) 2006-10-19 2011-05-03 Direct Flow Medical, Inc. Profile reduction of valve implant
US8142805B1 (en) 2006-11-06 2012-03-27 Clemson University Research Foundation Implantable devices including fixed tissues
US7678144B2 (en) * 2007-01-29 2010-03-16 Cook Incorporated Prosthetic valve with slanted leaflet design
KR100805831B1 (en) * 2007-02-06 2008-02-21 주식회사 사이언씨티 Template for individual aortic valve leaflet reconstruction
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US9138315B2 (en) * 2007-04-13 2015-09-22 Jenavalve Technology Gmbh Medical device for treating a heart valve insufficiency or stenosis
US9295551B2 (en) * 2007-04-13 2016-03-29 Jenavalve Technology Gmbh Methods of implanting an endoprosthesis
US8409274B2 (en) * 2007-04-26 2013-04-02 St. Jude Medical, Inc. Techniques for attaching flexible leaflets of prosthetic heart valves to supporting structures
CA2978267A1 (en) 2007-08-23 2009-02-23 Dfm, Llc Translumenally implantable heart valve with formed in place support
US8273118B2 (en) * 2007-09-17 2012-09-25 Medtronic, Inc. Heart valve holder assembly for use in valve implantation procedures
JP5106019B2 (en) * 2007-09-26 2012-12-26 崎 重 之 尾 Valve leaflet and its components
US7803186B1 (en) * 2007-09-28 2010-09-28 St. Jude Medical, Inc. Prosthetic heart valves with flexible leaflets and leaflet edge clamping
CN101868199B (en) 2007-10-12 2016-04-06 斯波瑞申有限公司 valve loader method, system and equipment
US9848981B2 (en) 2007-10-12 2017-12-26 Mayo Foundation For Medical Education And Research Expandable valve prosthesis with sealing mechanism
HRP20211382T1 (en) 2007-12-14 2021-12-24 Edwards Lifesciences Corporation Leaflet attachment frame for a prosthetic valve
US8317858B2 (en) 2008-02-26 2012-11-27 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US9168130B2 (en) 2008-02-26 2015-10-27 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8465540B2 (en) * 2008-02-26 2013-06-18 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis
US8398704B2 (en) 2008-02-26 2013-03-19 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
ES2903231T3 (en) 2008-02-26 2022-03-31 Jenavalve Tech Inc Stent for positioning and anchoring a valve prosthesis at an implantation site in a patient's heart
US9044318B2 (en) * 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
EP2119417B2 (en) 2008-05-16 2020-04-29 Sorin Group Italia S.r.l. Atraumatic prosthetic heart valve prosthesis
EP3799839A1 (en) * 2008-06-06 2021-04-07 Edwards Lifesciences Corporation Low profile transcatheter heart valve
ES2551694T3 (en) 2008-12-23 2015-11-23 Sorin Group Italia S.R.L. Expandable prosthetic valve with anchoring appendages
AU2010218384B2 (en) * 2009-02-27 2014-11-20 St. Jude Medical, Inc. Stent features for collapsible prosthetic heart valves
US8366767B2 (en) * 2009-03-30 2013-02-05 Causper Medical Inc. Methods and devices for transapical delivery of a sutureless valve prosthesis
CN102438553A (en) * 2009-03-31 2012-05-02 天成医疗有限公司 Leaflet alignment fixture and methods therefor
EP2246011B1 (en) 2009-04-27 2014-09-03 Sorin Group Italia S.r.l. Prosthetic vascular conduit
EP2424468A1 (en) * 2009-04-29 2012-03-07 Carlo Antona A prosthesis for repairing heart valves
NZ596179A (en) * 2009-04-29 2014-05-30 Cleveland Clinic Foundation Apparatus and method for replacing a diseased cardiac valve
US20100292779A1 (en) * 2009-05-15 2010-11-18 Helmut Straubinger Device for compressing a stent and a system as well as a method for loading a stent into a medical delivery system
US8348998B2 (en) * 2009-06-26 2013-01-08 Edwards Lifesciences Corporation Unitary quick connect prosthetic heart valve and deployment system and methods
DE102009042465A1 (en) * 2009-09-23 2011-03-31 Fehling Instruments Gmbh & Co. Kg Instrument for the surgical treatment of aortic valve defects
US8808369B2 (en) 2009-10-05 2014-08-19 Mayo Foundation For Medical Education And Research Minimally invasive aortic valve replacement
US10022222B2 (en) * 2009-10-06 2018-07-17 Adam Groothuis Systems and methods for treating lumenal valves
US9358109B2 (en) * 2010-01-13 2016-06-07 Vinay Badhwar Transcorporeal delivery system and method
US8795354B2 (en) 2010-03-05 2014-08-05 Edwards Lifesciences Corporation Low-profile heart valve and delivery system
CA2794750C (en) * 2010-03-26 2015-06-16 Thubrikar Aortic Valve, Inc. Valve component, frame component and prosthetic valve device including the same for implantation in a body lumen
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
WO2011139488A2 (en) 2010-05-06 2011-11-10 Mayo Foundation For Medical Education And Research Methods and materials for reducing cardiac xenograft rejection
CA2798711C (en) 2010-05-10 2019-08-27 Heart Leaflet Technologies, Inc. Stentless support structure
US8986374B2 (en) 2010-05-10 2015-03-24 Edwards Lifesciences Corporation Prosthetic heart valve
US9603708B2 (en) 2010-05-19 2017-03-28 Dfm, Llc Low crossing profile delivery catheter for cardiovascular prosthetic implant
US10856978B2 (en) 2010-05-20 2020-12-08 Jenavalve Technology, Inc. Catheter system
US11278406B2 (en) 2010-05-20 2022-03-22 Jenavalve Technology, Inc. Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect
IT1400327B1 (en) 2010-05-21 2013-05-24 Sorin Biomedica Cardio Srl SUPPORT DEVICE FOR VALVULAR PROSTHESIS AND CORRESPONDING CORRESPONDENT.
BR112012029896A2 (en) 2010-05-25 2017-06-20 Jenavalve Tech Inc prosthetic heart valve for stent graft and stent graft
US8845720B2 (en) * 2010-09-27 2014-09-30 Edwards Lifesciences Corporation Prosthetic heart valve frame with flexible commissures
DK2624785T3 (en) 2010-10-05 2021-05-10 Edwards Lifesciences Corp Heart valve prosthesis
US9078750B2 (en) 2010-11-30 2015-07-14 Edwards Lifesciences Corporation Ergonomic mitral heart valve holders
US9498317B2 (en) * 2010-12-16 2016-11-22 Edwards Lifesciences Corporation Prosthetic heart valve delivery systems and packaging
EP2486893B1 (en) 2011-02-14 2017-07-05 Sorin Group Italia S.r.l. Sutureless anchoring device for cardiac valve prostheses
EP2486894B1 (en) 2011-02-14 2021-06-09 Sorin Group Italia S.r.l. Sutureless anchoring device for cardiac valve prostheses
US9155619B2 (en) 2011-02-25 2015-10-13 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
US9968446B2 (en) 2011-03-23 2018-05-15 The Regents Of The University Of California Tubular scaffold for fabrication of heart valves
US8936650B2 (en) * 2011-03-23 2015-01-20 The Regents Of The University Of California Mesh enclosed tissue constructs
US9925296B2 (en) 2011-03-23 2018-03-27 The Regents Of The University Of California Mesh enclosed tissue constructs
US10610616B2 (en) 2011-03-23 2020-04-07 The Regents Of The University Of California Mesh enclosed tissue constructs
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US8968394B2 (en) 2011-05-12 2015-03-03 Edwards Lifesciences Corporation Mitral heart valve holder and storage system
EP2758010B1 (en) 2011-09-23 2017-02-08 Pulmonx, Inc Implant loading system
JP6005168B2 (en) 2011-10-21 2016-10-12 イエナバルブ テクノロジー インク Catheter system for introducing an expandable heart valve stent into a patient's body, insertion system equipped with a catheter system, and medical device for treating heart valve defects
EP2842517A1 (en) 2011-12-29 2015-03-04 Sorin Group Italia S.r.l. A kit for implanting prosthetic vascular conduits
EP2811939B8 (en) 2012-02-10 2017-11-15 CVDevices, LLC Products made of biological tissues for stents and methods of manufacturing
US9427315B2 (en) 2012-04-19 2016-08-30 Caisson Interventional, LLC Valve replacement systems and methods
US9011515B2 (en) 2012-04-19 2015-04-21 Caisson Interventional, LLC Heart valve assembly systems and methods
US20130289699A1 (en) * 2012-04-30 2013-10-31 St. Jude Medical, Cardiology Division, Inc. Aortic valve holder with stent protection and/or ability to decrease valve profile
US9445897B2 (en) 2012-05-01 2016-09-20 Direct Flow Medical, Inc. Prosthetic implant delivery device with introducer catheter
ES2962678T3 (en) * 2012-05-15 2024-03-20 Valve Medical Ltd System for assembling a folded percutaneous valve
EP2849678B1 (en) 2012-05-16 2022-08-10 JenaValve Technology, Inc. Catheter delivery system for introducing an expandable heart valve prosthesis and medical device for the treatment of a heart valve defect
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
NL2009145C2 (en) 2012-07-06 2014-01-07 Xeltis B V Implant.
US9693862B2 (en) 2012-07-31 2017-07-04 Edwards Lifesciences Corporation Holders for prosthetic heart valves
BR112015009802A2 (en) * 2012-10-30 2017-07-11 Veroux Pierfrancesco venous endoluminal device optimized for the treatment of vein defects
US20140228937A1 (en) 2013-02-11 2014-08-14 Joshua Krieger Expandable Support Frame and Medical Device
US11406497B2 (en) 2013-03-14 2022-08-09 Jc Medical, Inc. Heart valve prosthesis
EP2967810B1 (en) 2013-03-14 2020-04-22 Suzhou Jiecheng Medical Technology Co., Ltd. Embolic protection devices
US11259923B2 (en) 2013-03-14 2022-03-01 Jc Medical, Inc. Methods and devices for delivery of a prosthetic valve
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
CA2920724A1 (en) 2013-08-12 2015-02-19 Mitral Valve Technologies Sarl Apparatus and methods for implanting a replacement heart valve
WO2015028209A1 (en) 2013-08-30 2015-03-05 Jenavalve Technology Gmbh Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
EP2853237A1 (en) * 2013-09-25 2015-04-01 Universität Zürich Biological heart valve replacement, particularly for pediatric patients, and manufacturing method
US9050188B2 (en) 2013-10-23 2015-06-09 Caisson Interventional, LLC Methods and systems for heart valve therapy
US9414913B2 (en) 2013-10-25 2016-08-16 Medtronic, Inc. Stented prosthetic heart valve
US9622863B2 (en) 2013-11-22 2017-04-18 Edwards Lifesciences Corporation Aortic insufficiency repair device and method
US10098734B2 (en) 2013-12-05 2018-10-16 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
US9974647B2 (en) 2014-06-12 2018-05-22 Caisson Interventional, LLC Two stage anchor and mitral valve assembly
US10016272B2 (en) 2014-09-12 2018-07-10 Mitral Valve Technologies Sarl Mitral repair and replacement devices and methods
US9750607B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
US9750605B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
WO2016144391A1 (en) 2015-03-11 2016-09-15 Mvrx, Inc. Devices, systems, and methods for reshaping a heart valve annulus
DE102015206098B4 (en) * 2015-04-02 2018-09-27 Hans-Hinrich Sievers Implantation aid for a biological heart valve prosthesis and heart valve prosthesis system
US10709555B2 (en) 2015-05-01 2020-07-14 Jenavalve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
JP6595210B2 (en) * 2015-05-08 2019-10-23 株式会社日本医療機器開発機構 Aortic valve reconstruction training kit
US20170143478A1 (en) 2015-11-02 2017-05-25 Robert S. Schwartz Devices and methods for reducing cardiac valve regurgitation
CN113143539A (en) 2015-12-10 2021-07-23 姆维亚克斯股份有限公司 System for reshaping a heart valve annulus
WO2017117388A1 (en) 2015-12-30 2017-07-06 Caisson Interventional, LLC Systems and methods for heart valve therapy
CN108882981B (en) 2016-01-29 2021-08-10 内奥瓦斯克迪亚拉公司 Prosthetic valve for preventing outflow obstruction
US10363130B2 (en) 2016-02-05 2019-07-30 Edwards Lifesciences Corporation Devices and systems for docking a heart valve
EP3432835A4 (en) 2016-03-24 2019-03-27 Edwards Lifesciences Corporation Delivery system for prosthetic heart valve
CN109475419B (en) 2016-05-13 2021-11-09 耶拿阀门科技股份有限公司 Heart valve prosthesis delivery systems and methods for delivering heart valve prostheses through guide sheaths and loading systems
US10973631B2 (en) 2016-11-17 2021-04-13 Edwards Lifesciences Corporation Crimping accessory device for a prosthetic valve
US10463484B2 (en) 2016-11-17 2019-11-05 Edwards Lifesciences Corporation Prosthetic heart valve having leaflet inflow below frame
EP3541462A4 (en) 2016-11-21 2020-06-17 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
US10603165B2 (en) 2016-12-06 2020-03-31 Edwards Lifesciences Corporation Mechanically expanding heart valve and delivery apparatus therefor
US11654023B2 (en) 2017-01-23 2023-05-23 Edwards Lifesciences Corporation Covered prosthetic heart valve
US11185406B2 (en) 2017-01-23 2021-11-30 Edwards Lifesciences Corporation Covered prosthetic heart valve
US11013600B2 (en) 2017-01-23 2021-05-25 Edwards Lifesciences Corporation Covered prosthetic heart valve
CN110392557A (en) 2017-01-27 2019-10-29 耶拿阀门科技股份有限公司 Heart valve simulation
CN114631913A (en) 2017-05-22 2022-06-17 爱德华兹生命科学公司 Valve anchors and methods of installation
US20210401571A9 (en) 2017-05-31 2021-12-30 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
SG11201912180QA (en) 2017-06-30 2020-01-30 Edwards Lifesciences Corp Docking stations transcatheter valves
US10918473B2 (en) 2017-07-18 2021-02-16 Edwards Lifesciences Corporation Transcatheter heart valve storage container and crimping mechanism
IL301081A (en) 2017-08-11 2023-05-01 Edwards Lifesciences Corp Sealing element for prosthetic heart valve
US11083575B2 (en) 2017-08-14 2021-08-10 Edwards Lifesciences Corporation Heart valve frame design with non-uniform struts
US10932903B2 (en) 2017-08-15 2021-03-02 Edwards Lifesciences Corporation Skirt assembly for implantable prosthetic valve
US10898319B2 (en) 2017-08-17 2021-01-26 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
US10973628B2 (en) 2017-08-18 2021-04-13 Edwards Lifesciences Corporation Pericardial sealing member for prosthetic heart valve
US10722353B2 (en) 2017-08-21 2020-07-28 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
EP3672530A4 (en) 2017-08-25 2021-04-14 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US10973629B2 (en) 2017-09-06 2021-04-13 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
US11147667B2 (en) 2017-09-08 2021-10-19 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
CN210301305U (en) 2018-01-07 2020-04-14 苏州杰成医疗科技有限公司 Heart valve prosthesis delivery system
US11464639B2 (en) 2018-01-31 2022-10-11 Oregon Health & Science University Methods for creating sinus-matched aortic valves
US11318011B2 (en) 2018-04-27 2022-05-03 Edwards Lifesciences Corporation Mechanically expandable heart valve with leaflet clamps
CN112437649A (en) 2018-05-23 2021-03-02 索林集团意大利有限责任公司 Heart valve prosthesis
EP3840694B1 (en) 2018-08-22 2023-09-27 Edwards Lifesciences Corporation Automated heart valve manufacturing devices and methods
CA3116003A1 (en) 2018-10-19 2020-04-23 Edwards Lifesciences Corporation Prosthetic heart valve having non-cylindrical frame
JP7260930B2 (en) 2018-11-08 2023-04-19 ニオバスク ティアラ インコーポレイテッド Ventricular deployment of a transcatheter mitral valve prosthesis
WO2020198273A2 (en) 2019-03-26 2020-10-01 Edwards Lifesciences Corporation Prosthetic heart valve
EP3946163A4 (en) 2019-04-01 2022-12-21 Neovasc Tiara Inc. Controllably deployable prosthetic valve
CN113924065A (en) 2019-04-10 2022-01-11 内奥瓦斯克迪亚拉公司 Prosthetic valve with natural blood flow
EP3972673A4 (en) 2019-05-20 2023-06-07 Neovasc Tiara Inc. Introducer with hemostasis mechanism
WO2020257643A1 (en) 2019-06-20 2020-12-24 Neovasc Tiara Inc. Low profile prosthetic mitral valve
JP2022547247A (en) 2019-09-13 2022-11-11 エドワーズ ライフサイエンシーズ コーポレイション Adaptable devices and systems for docking in the circulatory system and methods thereof
EP4120962A1 (en) 2020-03-19 2023-01-25 Edwards Lifesciences Corporation Devices and systems for docking a heart valve
JP2023534384A (en) 2020-06-09 2023-08-09 エドワーズ ライフサイエンシーズ コーポレイション Automatic sewing and thread management
CN116194065A (en) 2020-06-18 2023-05-30 爱德华兹生命科学公司 Method for crimping
CA3199682A1 (en) 2020-11-10 2022-05-19 Edwards Lifesciences Corporation Docking station for a transcatheter heart valve
CN115813608A (en) 2021-09-17 2023-03-21 爱德华兹生命科学公司 Device and system for docking a heart valve

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3197788A (en) * 1962-04-23 1965-08-03 Inst Of Medical Sciences Prosthetic valve for cardiac surgery
US3714671A (en) * 1970-11-30 1973-02-06 Cutter Lab Tissue-type heart valve with a graft support ring or stent
US4291420A (en) 1973-11-09 1981-09-29 Medac Gesellschaft Fur Klinische Spezialpraparate Mbh Artificial heart valve
GB1443221A (en) * 1973-11-20 1976-07-21 Medac Klinische Spezialpraep Artificial heart valve
US4501030A (en) * 1981-08-17 1985-02-26 American Hospital Supply Corporation Method of leaflet attachment for prosthetic heart valves
US4451936A (en) 1981-12-21 1984-06-05 American Hospital Supply Corporation Supra-annular aortic valve
US5147391A (en) 1990-04-11 1992-09-15 Carbomedics, Inc. Bioprosthetic heart valve with semi-permeable commissure posts and deformable leaflets
US5584803A (en) * 1991-07-16 1996-12-17 Heartport, Inc. System for cardiac procedures
US5489297A (en) 1992-01-27 1996-02-06 Duran; Carlos M. G. Bioprosthetic heart valve with absorbable stent
US5258023A (en) * 1992-02-12 1993-11-02 Reger Medical Development, Inc. Prosthetic heart valve
US5449384A (en) 1992-09-28 1995-09-12 Medtronic, Inc. Dynamic annulus heart valve employing preserved porcine valve leaflets
AU2391795A (en) * 1994-04-22 1995-11-16 Medtronic, Inc. Stented bioprosthetic heart valve
US5728152A (en) 1995-06-07 1998-03-17 St. Jude Medical, Inc. Bioresorbable heart valve support
US5861028A (en) 1996-09-09 1999-01-19 Shelhigh Inc Natural tissue heart valve and stent prosthesis and method for making the same
US6074419A (en) 1996-12-31 2000-06-13 St. Jude Medical, Inc. Indicia for prosthetic device
US5928281A (en) * 1997-03-27 1999-07-27 Baxter International Inc. Tissue heart valves
US5964770A (en) * 1997-09-30 1999-10-12 Litana Ltd. High strength medical devices of shape memory alloy
US6254636B1 (en) 1998-06-26 2001-07-03 St. Jude Medical, Inc. Single suture biological tissue aortic stentless valve

Also Published As

Publication number Publication date
EP1143882A2 (en) 2001-10-17
ATE379998T1 (en) 2007-12-15
DE60037309D1 (en) 2008-01-17
IL144298A0 (en) 2002-05-23
BR0007745A (en) 2001-11-13
EP1990024A3 (en) 2014-05-28
JP2002535037A (en) 2002-10-22
WO2000042950A2 (en) 2000-07-27
DE60037309T2 (en) 2008-11-27
BR0007745B1 (en) 2009-01-13
EP1143882B1 (en) 2007-12-05
JP2010279730A (en) 2010-12-16
CA2358521C (en) 2009-12-29
CA2636711C (en) 2011-11-22
JP2009018180A (en) 2009-01-29
AU2737000A (en) 2000-08-07
JP4230118B2 (en) 2009-02-25
EP1990024A2 (en) 2008-11-12
US6338740B1 (en) 2002-01-15
WO2000042950A3 (en) 2000-11-30
CA2358521A1 (en) 2000-07-27
AU757091B2 (en) 2003-01-30
IL144298A (en) 2007-09-20
JP4701276B2 (en) 2011-06-15

Similar Documents

Publication Publication Date Title
CA2636711A1 (en) Flexible heart valve
US10342661B2 (en) Prosthetic mitral valve
EP0477325B1 (en) Bioprosthetic heart valve with elastic commissures
EP1924223B1 (en) Four-leaflet stented mitral heart valve
CA1069652A (en) Supported bioprosthetic heart valve with compliant orifice ring
US5147391A (en) Bioprosthetic heart valve with semi-permeable commissure posts and deformable leaflets
EP0150608B1 (en) Stent covering for tissue valves
US6558418B2 (en) Flexible heart valve
US20040225356A1 (en) Flexible heart valve
CA2461531C (en) Low-profile heart valve sewing ring
AU2005204649A1 (en) Bileaflet prosthetic valve and method of manufacture

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20200127