CA2642129A1 - Apparatus and methods for delivering fluid and material to a subject - Google Patents

Apparatus and methods for delivering fluid and material to a subject Download PDF

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Publication number
CA2642129A1
CA2642129A1 CA002642129A CA2642129A CA2642129A1 CA 2642129 A1 CA2642129 A1 CA 2642129A1 CA 002642129 A CA002642129 A CA 002642129A CA 2642129 A CA2642129 A CA 2642129A CA 2642129 A1 CA2642129 A1 CA 2642129A1
Authority
CA
Canada
Prior art keywords
syringe
main body
delivery device
micrometer
plunger
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002642129A
Other languages
French (fr)
Other versions
CA2642129C (en
Inventor
Terrell Pruitt
Stephen A. Cochran
Bryan Marshall
Yandong Su
Kurt Stricker Stenn
Kenneth Justin Washenik
John Depiano
Gary F. Prokop
Martin Rathgeber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aderans Research Institute Inc
Original Assignee
Aderans Research Institute, Inc.
Terrell Pruitt
Stephen A. Cochran
Bryan Marshall
Yandong Su
Kurt Stricker Stenn
Kenneth Justin Washenik
John Depiano
Gary F. Prokop
Martin Rathgeber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aderans Research Institute, Inc., Terrell Pruitt, Stephen A. Cochran, Bryan Marshall, Yandong Su, Kurt Stricker Stenn, Kenneth Justin Washenik, John Depiano, Gary F. Prokop, Martin Rathgeber filed Critical Aderans Research Institute, Inc.
Priority to CA2779561A priority Critical patent/CA2779561A1/en
Publication of CA2642129A1 publication Critical patent/CA2642129A1/en
Application granted granted Critical
Publication of CA2642129C publication Critical patent/CA2642129C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31586—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by rotationally moving or pivoted actuator, e.g. an injection lever or handle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2411—Ampoule inserted into the ampoule holder from the front
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2414—Ampoule inserted into the ampoule holder from the side
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M2005/341—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub angularly adjustable or angled away from the axis of the injector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M2005/342—Off-center needles, i.e. needle connections not being coaxial with the longitudinal symmetry axis of syringe barrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3148—Means for causing or aiding aspiration or plunger retraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31573—Accuracy improving means

Abstract

The present invention provides fluid and material delivery methods and devices for practicing the methods. The invention provides a method of delivering cellular material comprising injecting the cellular material into a subject such that the injected cells retain their inherent morphologic characteristics upon injection. The method comprises the steps of aspirating the cellular material into a fluid delivery device which incorporates a syringe arrangement. The cellular material is aspirated into the main body of the syringe until the desired amount of a material has filled the syringe body. The needle of the fluid delivery device is then inserted into the skin of a subject at an angle about parallel to the skin until a desired depth has been reached. The cellular material is then injected in the subject until the desired volume of material has been injected. The needle of the device is then rotated approximately 45 to 90 degrees and the needle is removed from the injection site.

Claims (61)

1. A fluid delivery device comprising:

a housing body having an exterior and an interior and a syringe cartridge aperture;

a pinion housing attached to the interior of the housing body, the pinion housing having a pinion receiving aperture;

a pinion which is received by the pinion receiving aperture, and attached to the pinion housing such that it can rotate within the pinion receiving aperture, the pinion comprising a front section having gear ridges, a syringe receiving aperture, and a rear section;

a detachable syringe cartridge having a head portion, a syringe body, a main portion, a plunger and a needle;

the head portion engages the housing body and is attached to the syringe body;

the syringe body has an interior channel;

the main body has an interior channel, the main body being attached to the syringe body and the interior channel of the main body having a threaded portion;
the plunger is received by the interior channels of the syringe body and the main body, the plunger having a plunger tip, a threaded screw section which engages with the threaded portion of the interior channel of the main body, and a tail section which is received by the syringe receiving aperture of the pinion and which engages with the rear section of the pinion;

the needle is attached to the head portion of the syringe cartridge and is operatively connected to the interior channel of the syringe body; and a trigger portion having a tab section which is adapted to engage with the gear ridges of the pinion when depressed, the trigger portion being attached at one end to the pinion housing.
2. The fluid delivery device of claim 1 wherein the housing body comprises a rear portion and a front portion.
3. The fluid delivery device of claim 2 wherein the pinion housing further comprises an exterior threaded portion and the rear and front portion of the housing body contain threaded portions in the interior of the housing bodies, wherein the threaded portions of the front and rear housing bodies engage the threaded portion of the pinion housing.
4. The fluid delivery device of any of the previous claims wherein the head portion of the syringe cartridge is made from a clear material.
5. The fluid delivery device of any of the previous claims wherein the tail section of the plunger is splined and the rear section of the pinion contains channels designed to receive the splines of the tail section of the plunger.
6. The fluid delivery device of any of the previous claims wherein the housing body has a longitudinal axis and wherein the needle is at an acute angle to the longitudinal axis of the housing body.
7. The fluid delivery device of claim 6 wherein the needle is at an approximately 40°
angle to the longitudinal axis of the housing body.
8. A micrometer assisted fluid delivery device comprising:

a holder portion comprising a main body having a front section and a back section;

a micrometer having a main body, an adjustment thimble and a spindle, wherein the main body of the micrometer is attached to the back section of the main body of the holder portion;

a syringe comprising a main body and a plunger, the main body of the syringe having an inner channel which receives the plunger, wherein the main body of the syringe is attached to the front section of the main body of the holder portion and the plunger is attached to the spindle of the micrometer.
9. The micrometer assisted fluid delivery device of claim 8 wherein the micrometer main body is attached to the back section of the main body within a micrometer receiving aperture located in the back section of the main body of the holder portion.
10. The micrometer assisted fluid delivery device of claim 8 or claim 9 wherein the main body of the syringe is attached to the front section of the main body within a syringe body receiving aperture located in the front section of the main body of the holder portion.
11. A micrometer assisted fluid delivery device comprising:

a holder portion comprising a main body having a front section, an intermediate section, and a back section;

the main body having a top, a bottom and two side walls;

the front section having a front face, a back face, side walls that extend from the side walls of the main body, and a syringe body receiving channel;

the intermediate section having a front face, a back face, side walls that extend from the side walls of the main body and a syringe plunger receiving channel;
the back section having a front face, a back face, side walls that extend from the side walls of the main body and a micrometer receiving aperture that passes from the front face to the back face of the back section;

a micrometer having a main body, an adjustment thimble and a spindle, wherein the main body of the micrometer is received by the micrometer receiving aperture of the back section of the holder portion;

a syringe comprising a main body finger tabs a plunger and a plunger tabbed end;

the main body of the syringe having an inner channel which receives the plunger and the main body of the syringe is received by the syringe body receiving channel:

the plunger is received by the syringe plunger receiving channel;
the finger tabs are positioned between the intermediate and the front section of the main body of the holder portion; and the spindle of the micrometer is in contact with the plunger head of the syringe.
12. The micrometer assisted fluid delivery device of claim 11 wherein the spindle is attached to the plunger tabbed end.
13. The micrometer assisted fluid delivery device of claim 11 or claim 12 wherein the back section of the main body of the holder portion further comprises a micrometer securing threaded aperture which receives a screw which can be tightened to secure the main body of the micrometer to the back section of the main body of the holder portion.
14. The micrometer assisted fluid delivery device of any one of claims 11 to wherein the front face of the front section of the main body of the holder portion has a threaded channel that receives a screw which can be tightened to secure the finger tab of the syringe to the intermediate section of the main body of the holder portion.
15. A micrometer assisted fluid delivery device comprising:

a holder portion comprising a main body having a front face, a back face, a top, a bottom, two side walls, an interior channel, a syringe finger tab channel, a syringe body channel, a syringe plunger channel and a micrometer receiving aperture which passes through the back face of the main body to the interior channel of the main body;

a micrometer having a main body an adjustment thimble and a spindle wherein the main body of the micrometer is received by the micrometer receiving aperture of the holder portion, a syringe comprising a main body, finger tabs, a plunger and a plunger tabbed end;

the main body of the syringe having an inner channel which receives the plunger and the main body of the syringe is received by the syringe body receiving channel of the holder portion;

the plunger is received by the syringe plunger channel of the holder portion;

the finger tabs are received by the syringe finger tab channel; and the spindle of the micrometer is in contact with the plunger head of the syringe.
16. The micrometer assisted fluid delivery device of claim 15 comprising a syringe plunger holder comprising a main body having a front face, a back face, a side wall, a syringe tabbed end channel which receives the syringe plunger tabbed end, and a syringe plunger channel which receives the syringe plunger, and a spindle channel which receives the spindle of the micrometer.
17. The micrometer assisted fluid delivery device of claim 16 wherein the main body of the syringe plunger holder further comprises a spindle securing threaded aperture that receives a screw which can be tightened to secure the spindle of the micrometer.
18. The micrometer assisted fluid delivery device of any one of claims 15 to wherein the main body of the holder portion further comprises a micrometer securing threaded aperture which receives a screw which can be tightened to secure the main body of the micrometer to the main body of the holder portion.
19. The micrometer assisted fluid delivery device of any one of claims 15 to wherein the front face of the main body of the holder portion has a threaded channel that receives a screw which can be tightened to secure the finger tab of the syringe to the main body of the holder portion.
20. A micrometer assisted fluid delivery device comprising a holder portion comprising a main body having a front face, a back face, a top, a bottom, side walls, a syringe body channel, a plunger yoke channel, and a micrometer receiving aperture located on the front face and passing through to the plunger yoke channel;

a micrometer having a main body, an adjustment thimble and a spindle, wherein the main body of the micrometer is received by the micrometer receiving aperture of the holder portion;

a syringe plunger yoke comprising a main body having a front face, a back face, a top, a bottom and side walls;

a syringe comprising a main body and a plunger;

the main body of the syringe having an inner channel which receives the plunger and the main body of the syringe is received by the syringe body channel of the holder portion;

the plunger is attached to the syringe plunger yoke; and wherein the spindle of the micrometer is attached to the syringe plunger yoke.
21. The micrometer assisted fluid delivery device of claim 20 wherein the plunger of the syringe is received by a syringe plunger channel located on the bottom of the syringe plunger yoke.
22. The micrometer assisted fluid delivery device of claim 21 wherein the syringe further comprises a plunger tabbed end which is received by a syringe plunger tabbed end channel located on the bottom of the syringe plunger yoke.
23. The micrometer assisted fluid delivery device of any one of claims 20 to wherein the spindle of the micrometer is attached to the syringe plunger yoke within a spindle receiving aperture, the spindle being fraction fit within the spindle receiving aperture.
24. The micrometer assisted fluid delivery device of any one of claims 20 to wherein the syringe further comprises finger tabs which are received by a syringe tab channel in the main body of the holder portion.
25. The micrometer assisted fluid delivery device of claim 24 wherein the device further comprises a syringe holder block received by the syringe tab channel, the syringe block holder having a syringe plunger channel that receives the syringe plunger, the syringe plunger block securing the finger tabs of the syringe to the main body of the holder portion by pressure exerted on the syringe plunger block by a spring located in a spring channel located in the main body of the holder portion, the spring channel extending from the back face of the main body of the holder portion to the syringe tab channel.
26. A method of delivering cellular material comprising injecting the cellular material into a subject, wherein the cellular material comprises cells that retain their inherent morphologic characteristics upon injection.
27. The method of claim 26, wherein the cellular material is injected with the device of claims 1, 8, 11, 15 or 20.
28. The method of claim 26 or claim 27, wherein the cells are selected from the group consisting of dermal cells, epidermal cells, epidermal stem cells, basal cells, keratinocytes, melanocytes, trichogenic dermal cells, fibroblasts, follicular progenitor cells, pancreatic islet cells, adipose cells, dental epithelial cells, dental dermal cells and combinations thereof.
29. The method of claim as in one of claims 26-28, wherein the cellular material further comprises a suspension media.
30. The method of any one of claims 26 to 29, wherein the cellular material is delivered to a subject in an amount effective to treat a disease or a physical condition which afflicts the subject.
31 The method of claim 30, wherein the disease or condition is hair loss
32 The method of claim 30, wherein the disease or physical condition is selected from the group consisting of hair loss, psoriasis, diabetes rhytids. skin atrophy, tooth loss. skin ulcers, bed sores, diabetic foot ulcers, burn wounds microbial infections, surgical scars, acne, chicken pox and combinations thereof.
33. The method of any one of claims 26 to 32, wherein the cells comprise follicular progenitor cells.
34. The method of claim 33, wherein the follicular progenitor cells are autologous.
35. The method of claim 34, wherein the cells comprise dermal cells.
36. The method of claim 34, wherein the cells comprise epidermal cells.
37. The method of any one of claims 26 to 36, wherein the cells are delivered to the skin of the subject.
38. The method of claim 37, wherein the cells are delivered to the skin's subepidermal layer, papillary dermal layer or upper reticular dermal layer.
39. A method of delivering a material into a subject's skin using the micrometer assisted fluid delivery device of claim 8 comprising the steps of:

i) aspirating a material into the micrometer assisted fluid delivery device by turning the micrometer adjustment thimble until the desired amount of the material has filled the syringe body of the micrometer assisted fluid delivery device;

ii) inserting the needle of the micrometer assisted fluid delivery device into the skin at an angle about parallel to skin until a desired depth has been reached;

iii) injecting the material by turning the micrometer adjustment thimble in increments until the desired volume has been injected;

iv) rotating the micrometer assisted fluid delivery device approximately 45 to 90 degrees; and v) removing the needle from the injection site
40. The method of claim 39, wherein the desired depth is four to six millimeters below the skin surface.
41 The method of claim 39 or claim 40, wherein the material is selected from the group consisting of botox, collagen, hyaluronic acid, antibiotics, anti-inflammatory drugs, steroids and combinations thereof.
42. The method of claim 39 or claim 40, wherein the material comprises cells.
43. The method of claim 42, wherein the cells are selected from the group consisting of dermal cells, epidermal cells, epidermal stem cells, basal cells, keratinocytes, melanocytes, trichogenic dermal cells, fibroblasts, follicular progenitor cells, pancreatic islet cells, adipose cells, dental epithelial cells, dental dermal cells and combinations thereof.
44. The method of claim 42 or 43, wherein the cells retain their inherent morphologic characteristics upon injection.
45. A method of delivering a material into a subject's skin using the fluid delivery device of claim 1 comprising the steps of:

i) loading the syringe cartridge into the housing body of the fluid delivery device, wherein the syringe body is filled with the material;

ii) inserting the needle of the fluid delivery device into the skin at an angle about parallel to skin until a desired depth has been reached;

iii) injecting the material by depressing the trigger portion of the fluid delivery device;

iv) rotating the fluid delivery device approximately 45 to 90 degrees; and v) removing the needle from the injection site.
46. The method of claim 45, wherein the desired depth is four to six millimeters below the skin surface.
47. The method of claim 45 or claim 46, wherein the material is selected from the group consisting of botox. collagen. hyaluronic acid, antibiotics, anti-inflammatory drugs, steroids and combinations thereof.
48. The method of claim 45 or claim 46, wherein the material is a cellular material comprising cells.
49. The method of claim 48, wherein the cells are selected from the group consisting of dermal cells, epidermal cells, epidermal stem cells, basal cells, keratinocytes, melanocytes, trichogenic dermal cells, fibroblasts, follicular progenitor cells, pancreatic islet cells, adipose cells, dental epithelial cells, dental dermal cells and combinations thereof.
50. The method of claim 48 or claim 49, wherein the cells retain their inherent morphologic characteristics upon injection.
51. A cellular material delivery device comprising an elongated shaft having a diameter, a latitudinal axis, a circumference and proximal, medial and distal portions, the distal portion having a sharpened point and the medial portion having series of annular grooves that run around the circumference of the shaft.
52. The cellular material delivery device of claim 51, wherein the sharpened point is a pencil shaped point.
53. The cellular material delivery device of claim 51, wherein the sharpened point is a trocar shape having three facetted sections.
54. The cellular material delivery device of claim 53, wherein the elongated shaft further comprises an axial channel that runs along a portion of the shaft and onto one of the facetted sections.
55. The cellular material delivery device of any one of claims 51 to 54, wherein the annular grooves are helically orientated around the medial portion of the shaft.
56 The cellular material delivery device of any one of claims 51 to 55, wherein the diameter of the shaft is less than 1 millimeter
57. The cellular material delivery device of any one of claims 51 to 56, wherein the annular grooves have a depth of less than 0.5 millimeters.
58. The cellular material delivery device of claim 57, wherein the annular grooves have a depth of approximately 0.15 millimeters.
59. The cellular material delivery device of any one of claims 51 to 58, wherein the annular grooves have a width of 0.5 millimeters or less.
60. The cellular material delivery device of claim 59, wherein the annular grooves have a width of approximately 0.2 millimeters.
61. A method of using the cellular delivery device of claim 51 to deposit cellular material under the surface of skin comprising the steps of:

i) depositing the material on the surface;

ii) piercing the surface using the sharpened point of the cellular delivery device;

iii) continuing insertion of the cellular delivery device into the surface, the annular grooves picking up the material from the surface and conveying the material beneath the surface; and iv) withdrawing the apparatus from the surface having deposited the material below the surface.
CA2642129A 2006-02-09 2007-02-08 Apparatus and methods for delivering fluid and material to a subject Expired - Fee Related CA2642129C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2779561A CA2779561A1 (en) 2006-02-09 2007-02-08 Apparatus and methods for delivering fluid and material to a subject

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US77191506P 2006-02-09 2006-02-09
US60/771,915 2006-02-09
US79148906P 2006-04-12 2006-04-12
US60/791,489 2006-04-12
US80324806P 2006-05-26 2006-05-26
US60/803,248 2006-05-26
PCT/US2007/061856 WO2007092929A2 (en) 2006-02-09 2007-02-08 Apparatus and methods for delivering fluid and material to a subject

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2779561A Division CA2779561A1 (en) 2006-02-09 2007-02-08 Apparatus and methods for delivering fluid and material to a subject

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CA2642129A1 true CA2642129A1 (en) 2007-08-16
CA2642129C CA2642129C (en) 2012-08-21

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US (3) US7780635B2 (en)
EP (3) EP1986731A4 (en)
JP (1) JP4910002B2 (en)
CN (2) CN102600548A (en)
AR (1) AR059424A1 (en)
AU (1) AU2007213706B2 (en)
CA (1) CA2642129C (en)
MX (1) MX2008010258A (en)
TW (2) TWI377074B (en)
WO (1) WO2007092929A2 (en)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8105580B2 (en) 2001-12-07 2012-01-31 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to promote wound healing
EP1921133B1 (en) 2001-12-07 2015-05-20 Cytori Therapeutics, Inc. System for processing lipoaspirate cells
US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
US7651684B2 (en) 2001-12-07 2010-01-26 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in augmenting autologous fat transfer
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
US9597395B2 (en) 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US20050220821A1 (en) * 2004-03-31 2005-10-06 Allergan, Inc. Pressure sore treatment
WO2010056759A1 (en) 2008-11-12 2010-05-20 The Trustees Of The University Of Pennsylvania Fibroblast growth factor-9 promotes hair follicle regeneration after wounding
CA2626199A1 (en) * 2005-10-17 2007-04-26 Aderans Research Institute, Inc. Method of delivering hair follicle progenitor cells to the skin
WO2007062386A2 (en) 2005-11-22 2007-05-31 Aderans Research Institute, Inc. Hair follicle graft from tissue engineered skin
EP1986731A4 (en) 2006-02-09 2012-11-07 Aderans Res Inst Inc Apparatus and methods for delivering fluid and material to a subject
US7922688B2 (en) 2007-01-08 2011-04-12 Restoration Robotics, Inc. Automated delivery of a therapeutic or cosmetic substance to cutaneous, subcutaneous and intramuscular tissue regions
US8036448B2 (en) 2007-04-05 2011-10-11 Restoration Robotics, Inc. Methods and devices for tattoo application and removal
US8208189B2 (en) * 2007-04-13 2012-06-26 Reliant Technologies, Inc. Treatment of alopecia by micropore delivery of stem cells
US7985537B2 (en) 2007-06-12 2011-07-26 Aderans Research Institute, Inc. Methods for determining the hair follicle inductive properties of a composition
US9656019B2 (en) 2007-10-02 2017-05-23 Medimop Medical Projects Ltd. Apparatuses for securing components of a drug delivery system during transport and methods of using same
US9345836B2 (en) 2007-10-02 2016-05-24 Medimop Medical Projects Ltd. Disengagement resistant telescoping assembly and unidirectional method of assembly for such
US7967795B1 (en) 2010-01-19 2011-06-28 Lamodel Ltd. Cartridge interface assembly with driving plunger
CN101868273B (en) 2007-10-02 2014-10-15 莱蒙德尔有限公司 External drug pump
US10420880B2 (en) 2007-10-02 2019-09-24 West Pharma. Services IL, Ltd. Key for securing components of a drug delivery system during assembly and/or transport and methods of using same
WO2009055610A1 (en) * 2007-10-26 2009-04-30 Cytori Therapeutics, Inc. Syringe system for controlled delivery or removal of material
US9044477B2 (en) * 2007-12-12 2015-06-02 Allergan, Inc. Botulinum toxin formulation
US20100291580A1 (en) * 2007-12-19 2010-11-18 Aderans Research Institute, Inc Biomarkers for trichogenicity
EP2326369B1 (en) 2008-05-30 2018-04-18 Allergan, Inc. Injection device for soft-tissue augmentation fillers, bioactive agents and other biocompatible materials in liquid or gel form
US7811261B2 (en) 2008-06-02 2010-10-12 Sta-Med, Llc Needle cover assembly for a syringe
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
US9393369B2 (en) 2008-09-15 2016-07-19 Medimop Medical Projects Ltd. Stabilized pen injector
US20100145305A1 (en) * 2008-11-10 2010-06-10 Ruth Alon Low volume accurate injector
RU2514896C2 (en) * 2008-12-02 2014-05-10 Аллерган, Инк. Device for injections
US20100179492A1 (en) * 2009-01-14 2010-07-15 Aderans Research Institute, Inc., Methods for increasing trichogenicity of dermal cells
AU2010242780B2 (en) 2009-05-01 2016-04-21 Puregraft Llc Systems, methods and compositions for optimizing tissue and cell enriched grafts
JP2012530492A (en) 2009-06-17 2012-12-06 アデランス リサーチ インスティテュート，インコーポレイティド Methods and compositions for increasing the ability of dermal cells to promote hair growth
WO2011011593A1 (en) 2009-07-23 2011-01-27 Aderans Research Institute, Inc. Identity markers
KR20120089236A (en) 2009-07-23 2012-08-09 아데란스 리서치 인스티튜트 인코포레이티드 Method for detecting/enriching trichogenic dermal cells, cells and use thereof in method of treatment of hair loss
US10071198B2 (en) 2012-11-02 2018-09-11 West Pharma. Servicees IL, Ltd. Adhesive structure for medical device
US10071196B2 (en) 2012-05-15 2018-09-11 West Pharma. Services IL, Ltd. Method for selectively powering a battery-operated drug-delivery device and device therefor
US8157769B2 (en) 2009-09-15 2012-04-17 Medimop Medical Projects Ltd. Cartridge insertion assembly for drug delivery system
EP2477676B1 (en) * 2009-09-15 2019-10-30 Becton, Dickinson and Company Self-injection device
US20110137260A1 (en) 2009-12-07 2011-06-09 Allergan, Inc. Slotted syringe
US8348898B2 (en) 2010-01-19 2013-01-08 Medimop Medical Projects Ltd. Automatic needle for drug pump
WO2011141907A1 (en) * 2010-05-10 2011-11-17 Medimop Medical Projects Ltd. Low volume accurate injector
AU2011255534A1 (en) 2010-05-19 2012-12-20 Allergan, Inc. Modular injection device
US8162882B2 (en) 2010-06-23 2012-04-24 Sta-Med, Llc Automatic-locking safety needle covers and methods of use and manufacture
US8246571B2 (en) * 2010-08-24 2012-08-21 Warsaw Orthopedic, Inc. Drug storage and delivery device having a retaining member
US9220501B2 (en) 2010-09-30 2015-12-29 Ethicon Endo-Surgery, Inc. Tissue thickness compensators
EP2455122A1 (en) * 2010-11-19 2012-05-23 Sanofi-Aventis Deutschland GmbH Drive mechanism for a drug delivery device
USD702834S1 (en) 2011-03-22 2014-04-15 Medimop Medical Projects Ltd. Cartridge for use in injection device
WO2012166746A1 (en) 2011-05-31 2012-12-06 Sta-Med, Llc Blood collection safety devices and methods of use and manufacture
US20140316369A1 (en) * 2011-11-14 2014-10-23 Regenerative Sciences, Llc Suspended particle delivery systems and methods
US8603028B2 (en) * 2011-11-18 2013-12-10 Allergan, Inc. Injection device having an angled tip portion
USD690004S1 (en) 2012-03-16 2013-09-17 Aderans Research Institute, Inc. Holder for a device for delivering cellular material and physiologic fluids
US9072827B2 (en) 2012-03-26 2015-07-07 Medimop Medical Projects Ltd. Fail safe point protector for needle safety flap
JP6040563B2 (en) * 2012-05-08 2016-12-07 高電工業株式会社 Puncture needle, jig for collecting a small amount of body fluid, and jig for dispensing a small amount of liquid
US9114216B2 (en) 2012-07-16 2015-08-25 Accunit, Llc Handheld medical substance dispensing system, apparatus and methods
US9724479B2 (en) * 2012-07-16 2017-08-08 Accunit, Llc Handheld medical substance dispensing system, apparatus and methods
WO2014028463A1 (en) 2012-08-14 2014-02-20 Allergan, Inc. Syringe for mixing and dispensing adipose tissue
US9421323B2 (en) 2013-01-03 2016-08-23 Medimop Medical Projects Ltd. Door and doorstop for portable one use drug delivery apparatus
WO2014151665A1 (en) 2013-03-14 2014-09-25 Boston Scientific Scimed, Inc. Injection devices with controllable depth adjustability and methods of use
US9011164B2 (en) 2013-04-30 2015-04-21 Medimop Medical Projects Ltd. Clip contact for easy installation of printed circuit board PCB
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
US20140350516A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Mechanical syringe accessory
USD748243S1 (en) * 2013-08-06 2016-01-26 Michael Perthu Auto-injector
USD756507S1 (en) * 2013-09-04 2016-05-17 Michael Perthu Auto-injector
GB201321078D0 (en) 2013-11-29 2014-01-15 Smiths Medical Int Ltd Syringe assemblies
KR101511775B1 (en) 2013-12-03 2015-04-13 주식회사 삼육오엠씨네트웍스 Liposuction cannula
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
ES2551810B1 (en) * 2014-05-21 2016-05-17 Kiro Robotics Sl ROBOTIZED SYRINGE ACTUATOR
US10583257B2 (en) * 2014-06-30 2020-03-10 BreezzAngel, LLC Method and apparatus for controlling the discharge rate of a syringe
US9764122B2 (en) 2014-07-25 2017-09-19 Warsaw Orthopedic, Inc. Drug delivery device and methods having an occluding member
US9775978B2 (en) 2014-07-25 2017-10-03 Warsaw Orthopedic, Inc. Drug delivery device and methods having a retaining member
GB2529621B (en) * 2014-08-21 2016-12-07 Owen Mumford Ltd Safety syringe
CN104173117A (en) * 2014-08-21 2014-12-03 安徽农业大学 Animal udder medicine injection needle
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
US9987041B2 (en) * 2014-11-03 2018-06-05 Follicular Technologies, Llc Disposable needle hair transplanter
CA2976544A1 (en) 2015-03-10 2016-09-15 Allergan Pharmaceuticals Holdings (Ireland) Unlimited Company Multiple needle injector
US10293120B2 (en) 2015-04-10 2019-05-21 West Pharma. Services IL, Ltd. Redundant injection device status indication
US10149943B2 (en) 2015-05-29 2018-12-11 West Pharma. Services IL, Ltd. Linear rotation stabilizer for a telescoping syringe stopper driverdriving assembly
EP3302652B1 (en) 2015-06-04 2023-09-06 Medimop Medical Projects Ltd. Cartridge insertion for drug delivery device
US9987432B2 (en) 2015-09-22 2018-06-05 West Pharma. Services IL, Ltd. Rotation resistant friction adapter for plunger driver of drug delivery device
US10576207B2 (en) 2015-10-09 2020-03-03 West Pharma. Services IL, Ltd. Angled syringe patch injector
CN108472438B (en) 2015-10-09 2022-01-28 西医药服务以色列分公司 Tortuous fluid path attachment to pre-filled fluid reservoirs
US10076650B2 (en) 2015-11-23 2018-09-18 Warsaw Orthopedic, Inc. Enhanced stylet for drug depot injector
JP6885960B2 (en) 2016-01-21 2021-06-16 ウェスト ファーマ サービシーズ イスラエル リミテッド Drug delivery device with visual indicators
JP6513297B2 (en) 2016-01-21 2019-05-22 ウェスト ファーマ サービシーズ イスラエル リミテッド Automatic injector, receiving frame and method of connecting cartridge in automatic injector
US10646643B2 (en) 2016-01-21 2020-05-12 West Pharma. Services IL, Ltd. Needle insertion and retraction mechanism
WO2017161076A1 (en) 2016-03-16 2017-09-21 Medimop Medical Projects Ltd. Staged telescopic screw assembly having different visual indicators
AU2017246114B2 (en) 2016-04-08 2022-03-17 Allergan, Inc. Aspiration and injection device
CN109310831B (en) 2016-06-02 2021-11-23 西医药服务以色列有限公司 Three position needle retraction
USD802755S1 (en) 2016-06-23 2017-11-14 Warsaw Orthopedic, Inc. Drug pellet cartridge
EP3490643B1 (en) 2016-08-01 2021-10-27 West Pharma. Services Il, Ltd. Anti-rotation cartridge pin
US11730892B2 (en) 2016-08-01 2023-08-22 West Pharma. Services IL, Ltd. Partial door closure prevention spring
US10434261B2 (en) 2016-11-08 2019-10-08 Warsaw Orthopedic, Inc. Drug pellet delivery system and method
EP3339424B1 (en) * 2016-12-23 2019-05-22 Eppendorf AG Manual injector for cell manipulation
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
CN110869072B (en) 2017-05-30 2021-12-10 西部制药服务有限公司(以色列) Modular drive mechanism for a wearable injector
US11246994B2 (en) * 2017-10-19 2022-02-15 Lifecell Corporation Methods for introduction of flowable acellular tissue matrix products into a hand
WO2019079672A1 (en) 2017-10-19 2019-04-25 Lifecell Corporation Flowable acellular tissue matrix products and methods of production
CN114470420A (en) 2017-12-22 2022-05-13 西氏医药包装(以色列)有限公司 Syringe adapted for cartridges of different sizes
JP7298629B2 (en) * 2019-03-29 2023-06-27 凸版印刷株式会社 Living body transfer device
WO2022235703A1 (en) * 2021-05-03 2022-11-10 The Children's Hospital Of Philadelphia Syringes and controllers for the same
FR3129290A1 (en) * 2021-11-24 2023-05-26 Collin Syringe support device, injection device and robotic installation for surgical intervention
US20230405098A1 (en) * 2022-06-16 2023-12-21 Innomed Technologies, Inc. Type e botulinum toxin to treat botulism

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1556085A (en) * 1922-11-04 1925-10-06 Pew Henry H De Surgical instrument
US2472116A (en) * 1945-10-18 1949-06-07 Emma C Maynes Syringe holder
US2474116A (en) * 1948-05-12 1949-06-21 Carnegie Illinois Steel Corp Apparatus for measuring differential speed
US2660342A (en) * 1949-04-01 1953-11-24 Ruf Herman Burette with variable capacity
US2853070A (en) * 1955-10-05 1958-09-23 Julliard Maurice Syringes
FR1318748A (en) * 1962-01-10 1963-02-22 Centre Nat Rech Scient Automatic rheometer
US3273763A (en) * 1965-01-22 1966-09-20 Roger Gilmont Instr Inc Micrometer buret
US3596292A (en) * 1969-02-20 1971-08-03 Franklin Institute Hair implant structure
JPS4960055A (en) * 1972-10-13 1974-06-11
US3799406A (en) * 1973-02-16 1974-03-26 Baxter Laboratories Inc Liquid injection apparatus for successive injection of equal metered volumes
US4458678A (en) * 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
ATE19203T1 (en) * 1981-11-12 1986-05-15 John Joseph Jacklich DENTAL SYRINGE.
US4659327A (en) * 1985-11-26 1987-04-21 Dentsply Research & Development Corp. Multiple dosage syringe
US5423778A (en) * 1989-12-14 1995-06-13 Elof Eriksson System and method for transplantation of cells
US5697901A (en) * 1989-12-14 1997-12-16 Elof Eriksson Gene delivery by microneedle injection
US5545208A (en) * 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5219099A (en) * 1991-09-06 1993-06-15 California Institute Of Technology Coaxial lead screw drive syringe pump
US5376542A (en) * 1992-04-27 1994-12-27 Georgetown University Method for producing immortalized cell lines using human papilluma virus genes
ZA941881B (en) * 1993-04-02 1995-09-18 Lilly Co Eli Manifold medication injection apparatus and method
US5611811A (en) * 1994-04-29 1997-03-18 Star-Wood, Inc. Micro and mini hair transplant device
US5782851A (en) * 1996-04-10 1998-07-21 Rassman; William R. Hair transplantation system
US5591444A (en) 1995-07-28 1997-01-07 Isolagen Technologies, Inc. Use of autologous dermal fibroblasts for the repair of skin and soft tissue defects
US5817120A (en) * 1997-02-10 1998-10-06 Rassman; William R. Hair implanting instrument
NL1005445C2 (en) 1997-03-05 1998-09-21 Gho St Holding B V Method of multiplying hair.
US5993374A (en) * 1997-06-17 1999-11-30 Radiance Medical Systems, Inc. Microcapsules for site-specific delivery
WO1999001034A1 (en) 1997-07-01 1999-01-14 Cooley Jerry E Method for producing new hair growth
US5957896A (en) * 1997-08-11 1999-09-28 Becton, Dickinson And Company Medication delivery pen
FR2770136B1 (en) * 1997-10-27 2000-03-10 Njc Innovations DEVICE FOR ADMINISTERING THERAPEUTIC SUBSTANCES WITH A MOTORIZED SYRINGE
CN1243578C (en) 1998-01-30 2006-03-01 诺沃挪第克公司 An injection syringe
US6660301B1 (en) * 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
US6027744A (en) * 1998-04-24 2000-02-22 University Of Massachusetts Medical Center Guided development and support of hydrogel-cell compositions
GB9817662D0 (en) * 1998-08-13 1998-10-07 Crocker Peter J Substance delivery
US6062753A (en) * 1998-08-17 2000-05-16 Pentech International Inc. Writing instrument with enhanced tactile control and gripping comfort and method of making same
AU769637B2 (en) * 1998-11-19 2004-01-29 Organogenesis Inc. Bioengineered tissue constructs and methods for producing and using them
WO2000045736A1 (en) 1999-02-08 2000-08-10 Bioamide, Inc. Filamentary means for introducing agents into cells
US6884427B1 (en) * 1999-02-08 2005-04-26 Aderans Research Institute, Inc. Filamentary means for introducing agents into tissue of a living host
DE60023677T2 (en) * 1999-04-16 2006-08-24 Becton Dickinson And Co. PENCIL INJECTOR WITH CHARACTERISTICS FOR AUTOMATIC SUBSTANCE COMBINATION
US7482114B2 (en) * 1999-10-06 2009-01-27 Tigenix N.V. In vivo assay and molecular markers for testing the phenotypic stability of cell populations, and selected cell populations for autologous transplantation
US20020193740A1 (en) * 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US6569143B2 (en) * 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
JP2001286493A (en) * 2000-02-03 2001-10-16 Shiro Yamada Artificial hair for transplant and method of manufacture
JP2003525722A (en) 2000-03-06 2003-09-02 ティーイーアイ バイオサイエンシズ，インコーポレイテッド Injectable biocompatible materials and methods of use
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
WO2001070289A2 (en) 2000-03-20 2001-09-27 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
US7338657B2 (en) * 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
WO2001070290A2 (en) 2000-03-20 2001-09-27 Biosphere Medical, Inc. Injectable microspheres for tissue construction
JP2001302520A (en) 2000-04-19 2001-10-31 Takahashi Akemasa Method for regenerating hair by cultured hair papilla cell
TW506890B (en) * 2000-05-24 2002-10-21 Netstal Ag Maschf Giesserei Enabling the entire machine to be provided with a short and compact structure
AU2001279209B2 (en) * 2000-08-08 2006-08-24 Aderans Research Institute, Inc. Scaffolds for tissue engineered hair
US6387077B1 (en) * 2000-10-13 2002-05-14 Mallinckrodt Inc. Apparatus and method for providing a suspended agent
MXPA03006714A (en) 2001-01-29 2005-04-08 Aderans Res Inst Inc Hair follicle neogenesis by injection of follicle progenitor cells.
AU2002252025A1 (en) * 2001-02-23 2002-09-12 University Of Massachusetts Injection molding of living tissues
WO2002083216A1 (en) 2001-04-13 2002-10-24 Becton Dickinson And Company Method of intradermally injecting substances
US6749792B2 (en) * 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
DE10163327A1 (en) * 2001-07-30 2003-02-27 Disetronic Licensing Ag Reservoir module with piston rod
EP2319562B1 (en) * 2001-12-13 2012-05-30 Panasonic Corporation Administration instrument for medical use
US20050089512A1 (en) * 2001-12-19 2005-04-28 Kordula Schlotmann Skin/hair equivalent with reconstructed papillae
JP2005519591A (en) * 2001-12-31 2005-07-07 イソラゲン テクノロジーズ，インコーポレーテッド Hair follicle growth
US20040068284A1 (en) * 2002-01-29 2004-04-08 Barrows Thomas H. Method for stimulating hair growth and kit for carrying out said method
US20030161815A1 (en) * 2002-02-12 2003-08-28 Intercytex Limited Cell delivery system
JP2003235990A (en) 2002-02-13 2003-08-26 Institute Of Immunology Co Ltd Method for discharging minute organismic material
US20030198646A1 (en) 2002-04-17 2003-10-23 Stenn Kurt Stricker Compositions and methods for inducing new hair follicle formation and hair growth in a desired orientation
NO20023724D0 (en) * 2002-08-07 2002-08-07 Amersham Health As Adapter
GB0304822D0 (en) * 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
US7156856B2 (en) * 2003-04-29 2007-01-02 Feller Alan S Method and apparatus for follicular extraction and transplantation
PT1656170T (en) * 2003-08-12 2019-05-31 Lilly Co Eli Medication dispensing apparatus with triple screw threads for mechanical advantage
BRPI0413867A (en) 2003-08-26 2006-10-24 Alza Corp device and method for intradermal cell implantation
CN2659454Y (en) * 2003-11-24 2004-12-01 李洪恩 Electric remote controlled constrast medium transferring device
EP1702632B1 (en) 2003-12-05 2012-10-31 Biointegrence Inc. Hair growth method
US20050233450A1 (en) * 2004-01-12 2005-10-20 Goetinck Paul F Methods of inducing hair growth
US7597885B2 (en) 2004-03-26 2009-10-06 Aderans Research Institute, Inc. Tissue engineered biomimetic hair follicle graft
ATE526052T1 (en) * 2004-03-30 2011-10-15 Lilly Co Eli MEDICATION DISPENSING DEVICE HAVING A GEAR SET WITH AN OPENING FOR RECEIVING A DRIVE ELEMENT
US20080114305A1 (en) * 2004-08-10 2008-05-15 Gerondale Scott J Botox® Injector
AR050212A1 (en) * 2004-08-13 2006-10-04 Aderans Res Inst Inc ORGANOGENESIS FROM DISCELLED CELLS
US20060057126A1 (en) * 2004-09-16 2006-03-16 Nikolai Tankovich Device and method for hair growth from stem cells
KR100616752B1 (en) 2004-11-29 2006-08-31 박정극 Method for preparation of dermal papilla tissue inducing hair folicle formation
TWI245653B (en) * 2005-01-27 2005-12-21 Wei-Shui Wu Safety syringe with needle head seat
CA2626199A1 (en) * 2005-10-17 2007-04-26 Aderans Research Institute, Inc. Method of delivering hair follicle progenitor cells to the skin
WO2007062386A2 (en) 2005-11-22 2007-05-31 Aderans Research Institute, Inc. Hair follicle graft from tissue engineered skin
US20070122387A1 (en) * 2005-11-22 2007-05-31 Aderans Research Institute, Inc. Hair grafts derived from plucked hair
JP4834389B2 (en) * 2005-11-29 2011-12-14 前田産業株式会社 Injection device
EP1986731A4 (en) * 2006-02-09 2012-11-07 Aderans Res Inst Inc Apparatus and methods for delivering fluid and material to a subject

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