CA2650920C - Patient customized therapeutic regimens - Google Patents
Patient customized therapeutic regimens Download PDFInfo
- Publication number
- CA2650920C CA2650920C CA2650920A CA2650920A CA2650920C CA 2650920 C CA2650920 C CA 2650920C CA 2650920 A CA2650920 A CA 2650920A CA 2650920 A CA2650920 A CA 2650920A CA 2650920 C CA2650920 C CA 2650920C
- Authority
- CA
- Canada
- Prior art keywords
- patient
- data
- therapeutic regimen
- pharmaceutical dosage
- confirmatory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q10/00—Administration; Management
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0026—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the transmission medium
- A61B5/0028—Body tissue as transmission medium, i.e. transmission systems where the medium is the human body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
- A61B5/073—Intestinal transmitters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4833—Assessment of subject's compliance to treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
- G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M8/00—Fuel cells; Manufacture thereof
- H01M8/02—Details
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04B—TRANSMISSION
- H04B13/00—Transmission systems characterised by the medium used for transmission, not provided for in groups H04B3/00 - H04B11/00
- H04B13/005—Transmission systems in which the medium consists of the human body
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M2220/00—Batteries for particular applications
- H01M2220/10—Batteries in stationary systems, e.g. emergency power source in plant
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/10—Energy storage using batteries
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/30—Hydrogen technology
- Y02E60/50—Fuel cells
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/903—Radio telemetry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/92—Computer assisted medical diagnostics
Abstract
Methods, systems and compositions that allow for treating a patient according to a patient customized therapeutic regimen are provided. Embodiments of the invention include obtaining dosage administration information from a patient and using the same to tailor a therapeutic regimen for the patient. Embodiments of the invention further include preparing and forwarding to the patient physical pharmaceutical dosages based on the customized therapeutic regimen.
Description
PATIENT CUSTOMIZED THERAPEUTIC REGIMENS
FIELD OF THE INVENTION =
The present Invention relates generally to health care and particularly to therapeutic regimens. More specifically, the present invention relates to methods and systems for treating patients according to patient specific customized therapeutic regimens that can be adjusted as a treatment protocol progresses.
BACKGROUND
Prescription medications are effective remedies for many patients when taken properly, e.g., according to instructions. However, prescription medications are generally taken according to predetermined dosing schedules that are developed using clinical data obtained from large patient populations. As such, when a health care practitioner determines that a patient will benefit from a given prescription medication, the health care practitioner generally assigns a standard dosage protocol to the patient, such as take once daily, take two times daily every 12 hours, etc.
While standard dosing regimens are based on clinical information taken from a large number of patients, such regimens do not take into account any physiological considerations that are unique to a given patient and may impact how a given pharmaceutical medication affects a particular patient. For example, such standard dosing schedules do not take into account the impact that any other medications which the patient may be taking may have on the activity of the prescribed medication. Furthermore, standard dosing schedules do not take into account any activity of an implanted medical device, e.g., a pacemaker, that may be present and operating on the patient. In addition, standard dosing schedules do not take into account any impact that non-compliance with the dosing schedule may have. Other parameters that are not accounted for in standard dosing schedules include a patient's daily anticipated activities, how a patient is subjectively feeling, etc.
Accordingly, standardized dosing regimens are not optimal dosing regimens for at least some patients that are prescribed medications for the treatment of a condition. Taking medications according to sub-optimal dosing regimens can have a variety of unwanted effects, including sub-optimal treatment, sub-optimal dompliance, toxic side effects, and even death.
Therefore, there is a need for the development of better methods of determining therapeutic regimens for patients. Of particular interest would be the development of methods for determining patient customized therapeutic regimens, where such regimens are tailored for a particular patient. The present invention satisfies this, and other, needs.
SUMMARY
The present invention allows, for the first time, the development of patient specific customized therapeutic regimens, in which doses of therapeutic interventions, e.g., pharmaceutical intervention, are specifically tailored for a given patient, where the doses can be determined based on a number of different patient specific criteria, such as the impact of other medications a patient is taking, the anticipated daily activities of the patient, and the like. The present invention also allows for the ability to modify a given therapeutic regimen over time, e.g., to account for changes unique to a given patient, such as how the patient is responding to prior treatment, how the patient has complied with prior dosing schedules, etc.
Embodiments of the invention include methods in which dosage administration data (particularly in the form of confirmatory data for administration of a medical composition), such as compliance data, is obtained from the patient.
This obtained confirmatory data is then evaluated, e.g., using automated decision
FIELD OF THE INVENTION =
The present Invention relates generally to health care and particularly to therapeutic regimens. More specifically, the present invention relates to methods and systems for treating patients according to patient specific customized therapeutic regimens that can be adjusted as a treatment protocol progresses.
BACKGROUND
Prescription medications are effective remedies for many patients when taken properly, e.g., according to instructions. However, prescription medications are generally taken according to predetermined dosing schedules that are developed using clinical data obtained from large patient populations. As such, when a health care practitioner determines that a patient will benefit from a given prescription medication, the health care practitioner generally assigns a standard dosage protocol to the patient, such as take once daily, take two times daily every 12 hours, etc.
While standard dosing regimens are based on clinical information taken from a large number of patients, such regimens do not take into account any physiological considerations that are unique to a given patient and may impact how a given pharmaceutical medication affects a particular patient. For example, such standard dosing schedules do not take into account the impact that any other medications which the patient may be taking may have on the activity of the prescribed medication. Furthermore, standard dosing schedules do not take into account any activity of an implanted medical device, e.g., a pacemaker, that may be present and operating on the patient. In addition, standard dosing schedules do not take into account any impact that non-compliance with the dosing schedule may have. Other parameters that are not accounted for in standard dosing schedules include a patient's daily anticipated activities, how a patient is subjectively feeling, etc.
Accordingly, standardized dosing regimens are not optimal dosing regimens for at least some patients that are prescribed medications for the treatment of a condition. Taking medications according to sub-optimal dosing regimens can have a variety of unwanted effects, including sub-optimal treatment, sub-optimal dompliance, toxic side effects, and even death.
Therefore, there is a need for the development of better methods of determining therapeutic regimens for patients. Of particular interest would be the development of methods for determining patient customized therapeutic regimens, where such regimens are tailored for a particular patient. The present invention satisfies this, and other, needs.
SUMMARY
The present invention allows, for the first time, the development of patient specific customized therapeutic regimens, in which doses of therapeutic interventions, e.g., pharmaceutical intervention, are specifically tailored for a given patient, where the doses can be determined based on a number of different patient specific criteria, such as the impact of other medications a patient is taking, the anticipated daily activities of the patient, and the like. The present invention also allows for the ability to modify a given therapeutic regimen over time, e.g., to account for changes unique to a given patient, such as how the patient is responding to prior treatment, how the patient has complied with prior dosing schedules, etc.
Embodiments of the invention include methods in which dosage administration data (particularly in the form of confirmatory data for administration of a medical composition), such as compliance data, is obtained from the patient.
This obtained confirmatory data is then evaluated, e.g., using automated decision
2 tools, to determine whether a change in the therapeutic regimen that has been prescribed to the patient is desired. Based on this determination, the decision tool provides a recommendation. If a change is recommended, the therapeutic regimen for the patient may then be modulated in some manner. In certain embodiments, the methods further include implementation of the revised = therapeutic regimen, e.g., in the form of preparation of a customized physical dosage according to the revised therapeutic regimen and forwarding of the same to the patient. Also provided are systems and programming for performing various steps of the subject methods.
BRIEF DESCRIPTION OF THE FIGURES
FIG. 1 presents a flow chart illustrating the process for developing a patient specific therapeutic regimen, in accordance with an embodiment of the present invention.
FIG. 2 presents a flow chart illustrating a variation of the process shown in FIG.1, in which the modified therapeutic regimen is implemented by production of patient-specific physical pharmaceutical dosages, in accordance to one embodiment of the present invention.
FIG. 3 provides an illustration of a specific embodiment of the present invention.
FIG. 4 depicts a system according to an embodiment of the invention for performing methods of the invention.
DEFINITIONS
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Still, certain elements are defined below for the sake of clarity and ease of reference.
By "remote location," it is meant a location other than the location at which a referenced item is present, e.g., a location apart from a patient, such as another physical location, (e.g., office, lab, etc.) in the same city, another location in a different city, another location in a different state, another location in a different country, etc. As such, when one item is indicated as being "remote" from
BRIEF DESCRIPTION OF THE FIGURES
FIG. 1 presents a flow chart illustrating the process for developing a patient specific therapeutic regimen, in accordance with an embodiment of the present invention.
FIG. 2 presents a flow chart illustrating a variation of the process shown in FIG.1, in which the modified therapeutic regimen is implemented by production of patient-specific physical pharmaceutical dosages, in accordance to one embodiment of the present invention.
FIG. 3 provides an illustration of a specific embodiment of the present invention.
FIG. 4 depicts a system according to an embodiment of the invention for performing methods of the invention.
DEFINITIONS
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Still, certain elements are defined below for the sake of clarity and ease of reference.
By "remote location," it is meant a location other than the location at which a referenced item is present, e.g., a location apart from a patient, such as another physical location, (e.g., office, lab, etc.) in the same city, another location in a different city, another location in a different state, another location in a different country, etc. As such, when one item is indicated as being "remote" from
3 another, what is meant is that the two items are at least in different areas of the same room, such as in different rooms or different buildings, and may be at least one mile, ten miles, or at least one hundred miles apart.
"Communicating" information references transmitting the data representing that information as signals (e.g., electrical, optical, radio signals, etc.) over a suitable communication channel (e.g., a private or public network), for example, a Wide Area Network ("WAN"), telephone network, satellite network, or any other suitable communication channel, including the Internet, an Intranet, etc.
Communicating may occur using any convenient communication module suitable for the type of communication channel used, such as a computer network card, a computer fax card or machine, or a telephone or satellite modem.
"Forwarding" an item refers to any means of getting that item from one location to the next, whether by physically transporting that item or otherwise (where that is possible) and includes, at least in the case of data, physically transporting a medium carrying the data or communicating the data, e.g., via ways described above.
The terms "system" and "computer-based system" refer to the hardware means, software means, and data storage means (e.g., a memory) used to practice aspects of the present invention. The minimum hardware of the computer-based systems of the present invention includes a central processing unit (CPU), input means; output means, and data storage means (e.g., a memory). A skilled artisan can readily appreciate that many computer-based systems are available which are suitable for use in the present invention. The data storage means may include any manufacture having a recording of the present information as described above, or a memory access means that can . access such a manufacture.
A "processor" references any hardware and/or software combination that will perform the functions required of it. For example, any processor herein may be a programmable digital microprocessor such as available in the form of an electronic controller, mainframe, server or personal computer (desktop or portable). Where the processor is programmable, suitable programming can be communicated from a remote location to the processor, or previously saved in a computer program product (such as a portable or fixed computer readable storage medium, whether magnetic, optical or solid state device based). For
"Communicating" information references transmitting the data representing that information as signals (e.g., electrical, optical, radio signals, etc.) over a suitable communication channel (e.g., a private or public network), for example, a Wide Area Network ("WAN"), telephone network, satellite network, or any other suitable communication channel, including the Internet, an Intranet, etc.
Communicating may occur using any convenient communication module suitable for the type of communication channel used, such as a computer network card, a computer fax card or machine, or a telephone or satellite modem.
"Forwarding" an item refers to any means of getting that item from one location to the next, whether by physically transporting that item or otherwise (where that is possible) and includes, at least in the case of data, physically transporting a medium carrying the data or communicating the data, e.g., via ways described above.
The terms "system" and "computer-based system" refer to the hardware means, software means, and data storage means (e.g., a memory) used to practice aspects of the present invention. The minimum hardware of the computer-based systems of the present invention includes a central processing unit (CPU), input means; output means, and data storage means (e.g., a memory). A skilled artisan can readily appreciate that many computer-based systems are available which are suitable for use in the present invention. The data storage means may include any manufacture having a recording of the present information as described above, or a memory access means that can . access such a manufacture.
A "processor" references any hardware and/or software combination that will perform the functions required of it. For example, any processor herein may be a programmable digital microprocessor such as available in the form of an electronic controller, mainframe, server or personal computer (desktop or portable). Where the processor is programmable, suitable programming can be communicated from a remote location to the processor, or previously saved in a computer program product (such as a portable or fixed computer readable storage medium, whether magnetic, optical or solid state device based). For
4 example, a magnetic medium or optical disk may carry the programming, and can be read by a suitable reader communicating with each processor at its = corresponding station.
A "memory," "memory element" or "memory unit" refers to any device that can store information for subsequent retrieval by a processor, and may include magnetic or optical devices (such as a hard disk, floppy disk, CD, or DVD), or solid-state memory devices (such as volatile or non-volatile RAM). A memory or memory unit may have more than one physical memory device of the same or different types (for example, a memory may have multiple memory devices such as multiple hard drives or multiple solid state memory devices or some combination of hard drives and solid state memory devices).
In certain embodiments, a system includes hardware components which take the form of one or more platforms, e.g., in the form of servers, such that any functional elements of the system, i.e., those elements of the system that carry out specific tasks (such as managing input and output ofinformation, processing information, etc.) of the system may be carried out by the execution of software applications on and across the one or more computer platforms represented of the system. The one or more platforms present in the subject systems may be any convenient type of computer platform, e.g., such as a server, main-frame computer, a work station, etc. Where more than one platform is present, the platforms may be connected via any convenient type of connection, e.g., cabling or other communication system including wireless systems, either networked or otherwise. Where more than one platform is present, the platforms may be co-located or they may be physically separated. Various operating systems may be employed on any of the computer platforms, where representative operating systems include Windows, Sun Solaris, Linux, OS/400, Compaq Tru64 Unix, SGI
IRIX, Siemens Reliant Unix, and others. The functional elements of system may also be implemented in accordance with a variety of software facilitators and platforms, as is known in the art.
DETAILED DESCRIPTION
The present invention provides the clinician important new tools in their therapeutic armamentarium--e.g., the ability to customize therapeutic regimens in.
A "memory," "memory element" or "memory unit" refers to any device that can store information for subsequent retrieval by a processor, and may include magnetic or optical devices (such as a hard disk, floppy disk, CD, or DVD), or solid-state memory devices (such as volatile or non-volatile RAM). A memory or memory unit may have more than one physical memory device of the same or different types (for example, a memory may have multiple memory devices such as multiple hard drives or multiple solid state memory devices or some combination of hard drives and solid state memory devices).
In certain embodiments, a system includes hardware components which take the form of one or more platforms, e.g., in the form of servers, such that any functional elements of the system, i.e., those elements of the system that carry out specific tasks (such as managing input and output ofinformation, processing information, etc.) of the system may be carried out by the execution of software applications on and across the one or more computer platforms represented of the system. The one or more platforms present in the subject systems may be any convenient type of computer platform, e.g., such as a server, main-frame computer, a work station, etc. Where more than one platform is present, the platforms may be connected via any convenient type of connection, e.g., cabling or other communication system including wireless systems, either networked or otherwise. Where more than one platform is present, the platforms may be co-located or they may be physically separated. Various operating systems may be employed on any of the computer platforms, where representative operating systems include Windows, Sun Solaris, Linux, OS/400, Compaq Tru64 Unix, SGI
IRIX, Siemens Reliant Unix, and others. The functional elements of system may also be implemented in accordance with a variety of software facilitators and platforms, as is known in the art.
DETAILED DESCRIPTION
The present invention provides the clinician important new tools in their therapeutic armamentarium--e.g., the ability to customize therapeutic regimens in.
5 a patient specific manner. The present invention allows therapeutic regimens to be developed and modified based on actual dosage administration information, i.e., confirmatory data for administration of a medical composition to a patient, which information can be supplemented with additional dosage relevant information, such as lifestyle information, etc. In this manner, patient specific customized optimal therapeutic regimens may be formulated by the clinician. By example, cardiac stimulating drugs can be titrated to the most appropriate dosages based on a number of factors, including actual compliance data, minimizing side effects such as cardiac muscle exhaustion and rebound effects among others, and optimizing both dosage and timing for each, individual patient.
Assessment of a range of alternate medications is made possible by the present invention without resort to awaiting overt clinical sequel of treatment, many of which can be seriously adverse. By example, positive effects would be quickly ascertainable without being obscured by more random factors. Negative responses, such as changes in blood pressure, would become clearly evident as drug related or independent above background physiologic variation. In one clinical arena, the present invention allows, in concert with other sensing devices, e.g., devices developed and owned by the assignee of the present application, the measurement and assessment of the cardiac response to those medications.
These co-employed sensing devices can be those enumerated below, among others. Other sensing technology developed by some of the present inventors allows measurement of heart health and cardiac efficiency. Using these tools in concert with the present inventive methods and systems, the clinician will be able to compare the response of the heart and body to the administered pharmaceutical and make patient specific customized therapeutic regimen modifications to achieve and optimal patient specific therapeutic regimen.
In further describing the invention in greater detail, the methods are reviewed first in greater detail. Next, systems for implementing the methods are described. Finally, representative applications in which the methods find use are reviewed.
METHODS
In one sense, the invention provides methods of treating a patient for a condition, where the condition may be a condition that benefits from some type of
Assessment of a range of alternate medications is made possible by the present invention without resort to awaiting overt clinical sequel of treatment, many of which can be seriously adverse. By example, positive effects would be quickly ascertainable without being obscured by more random factors. Negative responses, such as changes in blood pressure, would become clearly evident as drug related or independent above background physiologic variation. In one clinical arena, the present invention allows, in concert with other sensing devices, e.g., devices developed and owned by the assignee of the present application, the measurement and assessment of the cardiac response to those medications.
These co-employed sensing devices can be those enumerated below, among others. Other sensing technology developed by some of the present inventors allows measurement of heart health and cardiac efficiency. Using these tools in concert with the present inventive methods and systems, the clinician will be able to compare the response of the heart and body to the administered pharmaceutical and make patient specific customized therapeutic regimen modifications to achieve and optimal patient specific therapeutic regimen.
In further describing the invention in greater detail, the methods are reviewed first in greater detail. Next, systems for implementing the methods are described. Finally, representative applications in which the methods find use are reviewed.
METHODS
In one sense, the invention provides methods of treating a patient for a condition, where the condition may be a condition that benefits from some type of
6 medical intervention, such as pharmaceutical intervention, nutritional/vitamin intervention, fluid intervention (e.g., dialysis), etc., where some form of medical composition is administered to a patient. The term "medical composition" is used broadly to refer a variety of different types of compositions that may be administered to a patient for an ultimate goal of somehow improving the health of the patient, where examples of medical compositions include, but are not limited to: pharmaceuticals or drugs (e.g., which may be available by prescription or over the counter), a vitamin and nutriceuticals, therapeutic fluids, such as infusates, e.g., saline, dialysates, etc., antacids, etc. For convenience of description only, the invention is now further described primarily in terms of pharmaceutical medical compositions. However, the invention is not so limited.
In practicing the methods of the invention, a first step is to obtain dosage administration data from a patient (i.e., confirmatory data for administration of a medical composition to a patient), where the patient is, in certain embodiments, on a therapeutic regimen. By "on a therapeutic regimen" is meant that the patient has been prescribed a therapeutic protocol in which the patient is administered, either self-administered or by a health care practitioner or another-individual (or event the patient himself), a medical composition according to a dosing schedule, e.g., once every few hours, once a day, once every two days, once a week, etc.
In certain embodiments, the patient includes an implantable medical device that is involved in administration of the medical composition, such as a cardiovascular device, e.g., diabetes care device, drug administration device, etc.
Dosage administration data that is obtained in this step of the methods is information about whether or not, as well as when, a patient has been administered (either through self administration or by another individual) a given therapeutic invention, e.g., activity of implantable device, a pharmaceutical dosage, etc. The dosage administration data is confirmatory data for . administration of a medical composition to the patient. As the data is confirmatory, it is data that informs one that a particular composition has actually been administered to a patient. In certain embodiments, the confirmatory data is data that can only be generated when the medical composition actually contacts the patient, and therefore it is distinguishable from compliance data that may be generated from methods/systems which use a proxy for such contact, such as methods or systems that rely on patient recordation of administration, methods or
In practicing the methods of the invention, a first step is to obtain dosage administration data from a patient (i.e., confirmatory data for administration of a medical composition to a patient), where the patient is, in certain embodiments, on a therapeutic regimen. By "on a therapeutic regimen" is meant that the patient has been prescribed a therapeutic protocol in which the patient is administered, either self-administered or by a health care practitioner or another-individual (or event the patient himself), a medical composition according to a dosing schedule, e.g., once every few hours, once a day, once every two days, once a week, etc.
In certain embodiments, the patient includes an implantable medical device that is involved in administration of the medical composition, such as a cardiovascular device, e.g., diabetes care device, drug administration device, etc.
Dosage administration data that is obtained in this step of the methods is information about whether or not, as well as when, a patient has been administered (either through self administration or by another individual) a given therapeutic invention, e.g., activity of implantable device, a pharmaceutical dosage, etc. The dosage administration data is confirmatory data for . administration of a medical composition to the patient. As the data is confirmatory, it is data that informs one that a particular composition has actually been administered to a patient. In certain embodiments, the confirmatory data is data that can only be generated when the medical composition actually contacts the patient, and therefore it is distinguishable from compliance data that may be generated from methods/systems which use a proxy for such contact, such as methods or systems that rely on patient recordation of administration, methods or
7 systems that rely on smart packaging of medical compositions, etc. As such, dosage administration or confirmatory data employed in the methods of the invention .may include pharmaceutical compliance data, which compliance data includes information on if, including when, a patient received a particular pharmaceutical dosage.
In certain embodiments, the confirmatory data is data that is produced by a first device and is transmitted to a second device, where both of said first and second devices are associated with the body of said patient. In these situations, a first device that is associated with the body generates or produces a signal (which may be a collection of individual data elements, such as bits) when the medical composition has been administered to the patient. The signal is then transmitted to a second device which receives, and may record, the signal. The second device is also associated with the body. By associated with the body is meant that the first and second devices are in contact with the body, either topically or inside of the body, e.g., ingested, implanted, etc., depending the particular nature of the first and second devices.
An example of where the first and second devices are associated with a body of patient is where the first and second devices are electrically coupled to the body of a patient. As the devices are electrically coupled to the body of the patient, the confirmatory data may be transmitted from the first device to the second device by establishing an electrical current between the first and second devices, where the body serves as the conductive medium through which the electrical current travels, and therefore provides for "Coulombic"
communication between the first and second devices. Such embodiments are distinguished from devices that communicate with each via radio frequency (RF).
Depending on the nature of the first and second devices, the electrical current may be one that is confined among the first and second devices and the body of the patient. For example, where the first device is a pharma-informatics enabled pharmaceutical dosage (described in greater detail below), and the second device is a personal health companion implanted inside of or topically present on the patient, the electrical current that is established upon transmission of the data may be confined to the first and second devices and the patient.
Alternatively, the electrical current may be one that is confined between the first and second devices, wherein the first and second devices are capacitively
In certain embodiments, the confirmatory data is data that is produced by a first device and is transmitted to a second device, where both of said first and second devices are associated with the body of said patient. In these situations, a first device that is associated with the body generates or produces a signal (which may be a collection of individual data elements, such as bits) when the medical composition has been administered to the patient. The signal is then transmitted to a second device which receives, and may record, the signal. The second device is also associated with the body. By associated with the body is meant that the first and second devices are in contact with the body, either topically or inside of the body, e.g., ingested, implanted, etc., depending the particular nature of the first and second devices.
An example of where the first and second devices are associated with a body of patient is where the first and second devices are electrically coupled to the body of a patient. As the devices are electrically coupled to the body of the patient, the confirmatory data may be transmitted from the first device to the second device by establishing an electrical current between the first and second devices, where the body serves as the conductive medium through which the electrical current travels, and therefore provides for "Coulombic"
communication between the first and second devices. Such embodiments are distinguished from devices that communicate with each via radio frequency (RF).
Depending on the nature of the first and second devices, the electrical current may be one that is confined among the first and second devices and the body of the patient. For example, where the first device is a pharma-informatics enabled pharmaceutical dosage (described in greater detail below), and the second device is a personal health companion implanted inside of or topically present on the patient, the electrical current that is established upon transmission of the data may be confined to the first and second devices and the patient.
Alternatively, the electrical current may be one that is confined between the first and second devices, wherein the first and second devices are capacitively
8 coupled to a conductor or ground external to the patient. For example, where the first device is a smart parenteral delivery device, e.g., as described below, and the second device is a personal health companion that is present on a surface of the patient, the first and second devices may be capacitively coupled to a convenient ground external to the patient and, and the confirmatory data transmitted from the first device to the second device using an electrical current established in the body of the patient.
The system of the first and second device may be viewed as one the generates confirmatory data by broadcasting an electronic signal from the first device while a medication is being administered to the patient, e.g., from the first device; conducting the confirmatory signal through the patient to a receiver associated with said patient, e.g., a personal health companion device implanted in the patient or topically applied to the patient; and recording the confirmatory signal by the second device.
To provide for improved reliability, though not necessary to practice all aspects of the invention, the confirmatory data may be obtained using a system of a first and second device that automatically generates, transmits, receives and records the confirmatory data. The phrase "automatically" refers to a situation where, apart from an initial setup, no human intervention is required for the confirmatory data to be obtained.
In certain embodiments, individually detectable smart dosages may be employed as the first devices described in the above systems which generate the confirmatory data. Examples of such smart dosages include, but are not limited to, those described in: U.S. Patent No. 5,079,006 and published PCT
Publication Nos. WO 2007/027660; WO 2007/021496; WO 2007/014084; WO 2007/013952;
WO 2007/001742; WO 2007/001724; WO 2006/127355; WO 2006/104843; WO
2006/055892; WO 2001/047466; and WO 2005/020023.
Of particular interest in certain embodiments is the use of "smart" dosages that are activated upon contact with a target body location (e.g., the stomach), where activation occurs, for example, via completion of a power source. Such dosages may include identifiers associated with pharmaceutical compositions
The system of the first and second device may be viewed as one the generates confirmatory data by broadcasting an electronic signal from the first device while a medication is being administered to the patient, e.g., from the first device; conducting the confirmatory signal through the patient to a receiver associated with said patient, e.g., a personal health companion device implanted in the patient or topically applied to the patient; and recording the confirmatory signal by the second device.
To provide for improved reliability, though not necessary to practice all aspects of the invention, the confirmatory data may be obtained using a system of a first and second device that automatically generates, transmits, receives and records the confirmatory data. The phrase "automatically" refers to a situation where, apart from an initial setup, no human intervention is required for the confirmatory data to be obtained.
In certain embodiments, individually detectable smart dosages may be employed as the first devices described in the above systems which generate the confirmatory data. Examples of such smart dosages include, but are not limited to, those described in: U.S. Patent No. 5,079,006 and published PCT
Publication Nos. WO 2007/027660; WO 2007/021496; WO 2007/014084; WO 2007/013952;
WO 2007/001742; WO 2007/001724; WO 2006/127355; WO 2006/104843; WO
2006/055892; WO 2001/047466; and WO 2005/020023.
Of particular interest in certain embodiments is the use of "smart" dosages that are activated upon contact with a target body location (e.g., the stomach), where activation occurs, for example, via completion of a power source. Such dosages may include identifiers associated with pharmaceutical compositions
9 =
and provide information (i.e., confirmatory data) about when a patient is actually . administered the dosage (e.g., by emitting a signal upon contact with a targeted physiological site, such as the stomach), such that the information obtained is not a proxy for the dosage administration but is, in fact, tied to actual administration of the dosage. Smart dosages of this type include those described in PCT
application serial no. PCT/ US2006/016370 titled "Pharma Informatics System"
which was filed on April 28, 2006 and published as WO 2006/116718 on November 2, 2006; as well as the additional embodiments of such smart dosages as described in United States Provisional Application Serial Nos. 60/866,581;
60/829,832; 60/887,780; 60/889,868; 60/889,870; 60/889,871; 60/894,171 and 60/894,167., Such dosages may be viewed as pharma-informatics enabled dosages.
Dosage compliance data can also be obtained using smart therapeutics systems, e.g., systems that provide specific identification and detection of beneficial agents or beneficial agents taken into the body through other methods, for example, through the use of a syringe, inhaler, infusion machine, dialysis machine, or other device that administers medicine. The smart therapeutics system can include a beneficial agent with a chip. The chip can contain information about the type of beneficial agent to be administered to the patient.
Upon extracting the beneficial agent from the holding container, e.g., a vial, a signal can be sent from the vial to a chip within the syringe. The broadcasted signal can indicate the type of beneficial agent extracted from the vial. Upon injection into the patient, the information can be sent from the syringe to an information management database located. in, on, or near the patient, e.g., a personal health companion device. The system can also notify the receiver about any therapies the patient is undergoing, such as dialysis. In this case, the dialysis machine, or an add-on module added to current dialysis machines, can be used to collect and transmit data about the dialysis being performed and parameters of the blood going out of and in to the patient during dialysis.
Upon successful detection and decoding of the transmitted signal, the receiver can activate an alert to let the nurse or other attending person and/or the patient that the receiver has successfully received information about the medication or therapy which was administered. Such systems are disclosed in United States Provisional Patent Application Nos. 60/819,750 filed July 7, 2006 and 60/891,883 'filed February 27, 2007_ As indicated above, the second device may be a device configured to receive data transmitted through a body from the first device (and record and retransmit the data where desired), where the second device may be a personal health companion device that is configured to detect dosage administration, e.g., by a signal emitted by an identifier of a pharma-informatics enabled dosage formulation, such as described in pending provisional application serial no.
60/887,780 titled "Signal Receivers for Pharma-lnformatics Systems"; the disclosure of which is herein incorporated by reference. As mentioned above, the personal health companion may be dimensioned for implantation and or topical application to a patient, where the device is dimensioned such that however it is associated with the patient it can be associated with the patient for extended periods of time, e.g., days, weeks, months, years or longer, without causing substantial if any discomfort to the patient.
In certain of the above described embodiments, the first device and the second device ar6 different types of devices, e.g., where the first device may be associated with an active agent, such as where the first device is a smart dosage, and the second device is not associated with an active agent.
In certain embodiments, the methods included obtaining from the patient two or more sets of a confirmatory over a given period of time, e.g., 2 or more sets of confirmatory data over a period of 1 day, 1 week,. 1 month, 1 year, etc., depending on the particular regimen of the patient. While the two or more sets of confirmatory data may be generated from the same first device, in certain embodiments, e.g., where the first device is a pharma-informatics enabled dosage, e.g., such as a smart dosage described above, the first and second devices will be different dosages, e.g., different pills. As such, embodiments of the methods include obtaining an additional set of confirmatory data from at least a third device, e.g., a second pharmaceutical dosage which is separate from the first pharmaceutical dosage, where the same second device is employed regardless of how many additional first, third, etc., devices are employed.
In addition to dosage administration data, additional data may be obtained from the patient as desired. Types of additional patient data that may be obtained include, but are not limited to: physiological parameter data, e.g., as may be obtained using any convenient sensing device, including the sensors and systems developed by some of the inventors of the assignee of the present application and described in co-owned applications and patents, as referenced below; lifestyle data, such as historical information about the patient (e.g., the patients activities on a given day, how the patient was feeling, etc.);
anticipated activities of the patient (e.g., whether or not the patient expects to exercise, whether or not the patient is feeling well, etc.); and the like.
Following obtainment of the dosage administration (i.e., confirmatory) data from the patient, e.g., where the patient may or may not be in a remote location such that obtainment of the data includes transmitting the data from a first location to a second location (for example over the internet) the data is then evaluated, e.g., using a system as reviewed below, to determine when a change in the therapeutic regimen is desired and provide a recommendation based on the determination. This step of the methods may include inputting the data into a decision support tool (e.g., of an appropriate system) and obtaining from the decision support tool a recommendation based on the confirmatory data as to whether a change is the therapeutic regimen is desirable. The dosage administration data is assessed to identify whether, based on the information received from the patient, such as compliance data, physiological parameters and lifestyle data, any modification should be made to the therapeutic regimen in order to optimize the therapeutic regimen for the patient in some way. The data may be evaluated by a health care practitioner, e.g., manually or through use of any convenient decision tool, e.g., such as the system described below, that may include a database, algorithm, actionable interface (e.g., in the form of a graphical user interface (GUI)), outcome measure, etc.
The resultant recommendation based on this evaluation step may then be employed, e.g., by a health care professional, to determine whether the therapeutic regimen should be modulated in some manner. The determination is then communicated, e.g., by a health care practitioner, to the patient, where the determination may be in the form of an indication that no change in the therapeutic regimen should be made or that a change in the therapeutic regimen should be made. As such, the health care practitioner may inform the patient that no change in therapeutic regimen should be made and that the patient should continue to follow the therapeutic regimen as previously specified to the patient.
Alternatively, the health care practitioner, following a recommendation from the evaluation step, may also forward to the patient a modified therapeutic regimen, e.g., in the form of instructions on how to change the regimen as previously specified to the patient.
The modulation of the therapeutic regimen, when made, may take a variety of different formats. For example, the modulation may take the form of a change in a pharmaceutical dosage regimen, e.g., in the amounts of active agent taken and/or the different types of active agents taken. The modulation may also take the form of a change in the activity of an implanted medical device. In addition, the modification may include lifestyle alteration recommendations, e.g., instructions to refrain from exercise, instructions to engage in exercise, instructions to modify diet, etc.
In certain embodiments, the methods may further include implementation of change in a therapeutic regimen. This implementation may be manifested in a number of different ways. For example, this implementation may be in the form of the preparation of one or more actual, physical pharmaceutical dosages that will be used in the therapeutic regimen as modified. The phrase "physical pharmaceutical dosage" refers to the actual pharmaceutical composition(s) that is administered at any given time, e.g., the actual one or more pills that are administered at a given administration event. In one form of implementation, a modified therapeutic regimen that includes a selection of different active agents in specific amounts is implemented by collecting different compositions, e.g., pills, of the active agents into a set and forwarding the set to the patient. In another form of implementation, a combination of two or more active agents in amounts specified by a therapeutic regimen as described above are combined into a single composition, and the composition is then forwarded to the patient. For example, a given modified therapeutic regimen determined as described above may call for the administration of a first amount of pharmaceutical X, a second amount pharmaceutical Y and a third amount of pharmaceutical Z. A single composition is made, e.g., by a pharmaceutical composition manufacturer in response to instructions from a system, as reviewed in greater detail below, that includes all three different pharmaceuticals in the amounts specified. The three different amounts may be present in different compartments of an inert carrier, combined in a capsule, etc., as desired. The compositions of these embodiments may be manufactured at any point along a given supply chain, e.g., at the pharmaceutical agent manufacturer level, at a distributor level, at a retail (e.g., pharmacy) level or even at the customer level, e.g., by using a home device that prepares customized formulations from stock components. Implementation may also include modulation Of the activity of an implanted device, such as a cardiac device, neurostimulatory device, etc., as may be desirable.
In certain embodiments, additional methods and systems of monitoring or tracking individual dosages or collections of dosages may be employed in conjunction, with the methods and systems of the present invention. For example, "smart package devices (i.e., pharmaceutical compliance packages) which record when a patient obtains a dosage from the package and thereby provides a proxy for the administration of the dosage to the patient may be employed.
Examples of such "smart" packaging devices and methods are found in, but not limited to: smart drug dispensers as disclosed in U.S. Pat. Nos. 4,360,125;
4,768,176; 4,768,177; 5,200,891; 5,642,731; 5,752,235 and 5,954,641.
Alternatively or in addition, RFID/barcode approaches= may be employed to provide additional confirmation or tracking information between a source of pharmaceutical dosages and patient.
Other sources of dosage compliance data include, but are not limited to, patient data recordation, e.g., via input into a compliance recordation program, etc. Dosage administration data can also include implantable medical device activity data, such as pacemaker activity data, where such activity may be monitored using any convenient system, including the system described in published PCT Application Publication No. WO 2007/028035 titled " Implantable Zero-Wire Communications System", Such additional sources of information may be employed in conjunction with the methods of invention, where desired.
FIGS. 1 and 2 provide flow charts of two different embodiments of the methods described above. In FIG. 1, the first step 110 of the exemplified method is to obtain dosage administration data, such as pharmaceutical compliance data, as reviewed above. Next, at step 120 the obtained dosage administration data is input into a therapeutic regimen evaluator, e.g., as described in greater detail below. Following step 120, the evaluator assesses at step 130 the input data to determine whether a change in the therapeutic regimen is desired. At decision box 140, if a change is the regimen is not recommended, instructions are =
forwarded to the patient to continue with the current therapeutic regimen, as shown at step 150. However, if a change in the regimen is recommended at decision box 140, a modified therapeutic regimen, e.g., in the form of a changed pharmaceutical dosage regimen and/or implanted medical device activity regimen, is developed at step 160. The developed modulated pharmaceutical dosage regimen is then forwarded to the patient at step 170. Finally, the patient proceeds by continuing to follow the prior therapeutic regimen or adopting the modified regimen, as shown at step 180.
FIG. 2 provides a modified version of the protocol shown in FIG. 1, where the method includes an implementation of the modified therapeutic regimen. In FIG. 2, the first step 210 of the exemplified method is to obtain dosage administration data, such as pharmaceutical compliance data, as reviewed above. Next, at step 220 the obtained dosage administration data is input into a therapeutic regimen evaluator, e.g., as described in greater detail below.
Following step 220, the evaluator assesses at step 230 the input data to determine whether a change in the therapeutic regimen is desired. At decision box 240, if a change is the regimen is not recommended, instructions are forwarded to the patient to continue with the current therapeutic regimen, as shown at step 250. At step 250, instructions are also sent to the patient to continue with the implementation of the prior therapeutic regimen, e.g., by taking the same pharmaceutical compositions according to the same dosing schedule, etc. However, if a change in the regimen is recommended at decision box 240, a modified therapeutic regimen, e.g., in the form of a changed pharmaceutical dosage regimen and/or implanted medical device activity regimen, is developed at step 260. The resultant modified therapeutic regimen is implemented as desired, e.g., by fabricating a physical pharmaceutical dosage (as described above) at step 270.The developed modulated pharmaceutical dosage regimen and implementation thereof is then forwarded to the patient at step 275.
Finally, the patient proceeds by continuing to follow the prior therapeutic regimen or adopting the modified regimen, along with the implementation thereof, as shown at step 280.
SYSTEMS
Also provided by the subject invention are systems that may be used to perform on or more aspects of the methods, such as the data evaluation step, e.g., as described above. In certain embodiments, the systems include a decision tool, e.g., in the form of a processor accessing a database and running an appropriate algorithm, which may take the form of a data evaluation module, which serves as a therapeutic regimen evaluator to assess the input data and provide a recommendation of whether or not a change is desired.
In the process schematically depicted in FIG. 1, a data evaluation module is employed as a therapeutic regimen evaluator to assess the input data and generate a recommendation as to whether or not the regimen should be changed. As such, the data evaluation module performs the function of receiving the input information and generating the regimen recommendation information in response thereto.
The data evaluation module employed in the subject methods may include a collection dosage administration data (e.g., compliance data) element and regimen recommendation linked data element stored in a memory, such as a database. The data elements of the module may be organized in any convenient manner. The content of the data evaluation module may be controlled using any convenient protocol. In certain embodiments, the content may be maintained by a single entity, e.g., where the entity initially creates the content and then updates the content periodically. Embodiments of the modules include updated modules in which the content of the module has been updated one or more times following its manufacture, e.g., two or more times, 5 or more times, 10 or more times, 50 or more times, 100 or more times, 1000 or more times, etc., where the updated =
content may be any of a variety of different types of information.
An embodiment of a system .that includes a data evaluation module is shown in FIG. 3. In FIG. 3, system 300 includes communications module 320 and processing module 330, where each module may be present on the same or different platforms, e.g., servers, as is known in the art. The communications module includes an input manager 322 and output manager 324 functional elements. Input manager 322 receives information, e.g., sample identifier information, from a user e.g., locally or from a remote location (such as over the Internet). Input manager 322 processes and forwards this information to the =
processing module 330. Output manager 324 provides information assembled by processing module 330, e.g., a modified therapeutic regimen, to a user. The communications module 320 may be operatively connected to a user computer 310 by communications element 315, which element provides a vehicle for a user to interact with the system 300. User computer 310, shown in FIG. 3, may be a computing device specially designed and configured to support and execute any of a multitude of different applications. Computer 310 also may be any of a variety of types of general-purpose computers such as a personal computer, network server, workstation, or other computer platform now or later developed.
As reviewed above, the systems include various functional elements that carry out specific tasks on the platforms in response to information introduced into the system by one or more users. In FIG. 3, elements 332, 334 and 336 represent three different functional elements of processing module 330.
At least one of the functional elements 332 of processing module 330 is a functionality for assessing the dosage administration data and providing a determination as to whether a change in at therapeutic dosage regimen is desired, and is conveniently referred to herein as the therapeutic regimen evaluator. Additional functional elements that may be present include, but are not limited to, elements for determining modified therapeutic regimens, etc.
In certain embodiments, the systems include one or more implantable devices, which may have therapeutic (such as electrostimulatory) and/or sensory activity.
Such sensors and systems include, but are not limited to, those described in various applications assigned to the assignee of the present application, where such applications include, but are not limited to: U.S. Patent Application No.
and provide information (i.e., confirmatory data) about when a patient is actually . administered the dosage (e.g., by emitting a signal upon contact with a targeted physiological site, such as the stomach), such that the information obtained is not a proxy for the dosage administration but is, in fact, tied to actual administration of the dosage. Smart dosages of this type include those described in PCT
application serial no. PCT/ US2006/016370 titled "Pharma Informatics System"
which was filed on April 28, 2006 and published as WO 2006/116718 on November 2, 2006; as well as the additional embodiments of such smart dosages as described in United States Provisional Application Serial Nos. 60/866,581;
60/829,832; 60/887,780; 60/889,868; 60/889,870; 60/889,871; 60/894,171 and 60/894,167., Such dosages may be viewed as pharma-informatics enabled dosages.
Dosage compliance data can also be obtained using smart therapeutics systems, e.g., systems that provide specific identification and detection of beneficial agents or beneficial agents taken into the body through other methods, for example, through the use of a syringe, inhaler, infusion machine, dialysis machine, or other device that administers medicine. The smart therapeutics system can include a beneficial agent with a chip. The chip can contain information about the type of beneficial agent to be administered to the patient.
Upon extracting the beneficial agent from the holding container, e.g., a vial, a signal can be sent from the vial to a chip within the syringe. The broadcasted signal can indicate the type of beneficial agent extracted from the vial. Upon injection into the patient, the information can be sent from the syringe to an information management database located. in, on, or near the patient, e.g., a personal health companion device. The system can also notify the receiver about any therapies the patient is undergoing, such as dialysis. In this case, the dialysis machine, or an add-on module added to current dialysis machines, can be used to collect and transmit data about the dialysis being performed and parameters of the blood going out of and in to the patient during dialysis.
Upon successful detection and decoding of the transmitted signal, the receiver can activate an alert to let the nurse or other attending person and/or the patient that the receiver has successfully received information about the medication or therapy which was administered. Such systems are disclosed in United States Provisional Patent Application Nos. 60/819,750 filed July 7, 2006 and 60/891,883 'filed February 27, 2007_ As indicated above, the second device may be a device configured to receive data transmitted through a body from the first device (and record and retransmit the data where desired), where the second device may be a personal health companion device that is configured to detect dosage administration, e.g., by a signal emitted by an identifier of a pharma-informatics enabled dosage formulation, such as described in pending provisional application serial no.
60/887,780 titled "Signal Receivers for Pharma-lnformatics Systems"; the disclosure of which is herein incorporated by reference. As mentioned above, the personal health companion may be dimensioned for implantation and or topical application to a patient, where the device is dimensioned such that however it is associated with the patient it can be associated with the patient for extended periods of time, e.g., days, weeks, months, years or longer, without causing substantial if any discomfort to the patient.
In certain of the above described embodiments, the first device and the second device ar6 different types of devices, e.g., where the first device may be associated with an active agent, such as where the first device is a smart dosage, and the second device is not associated with an active agent.
In certain embodiments, the methods included obtaining from the patient two or more sets of a confirmatory over a given period of time, e.g., 2 or more sets of confirmatory data over a period of 1 day, 1 week,. 1 month, 1 year, etc., depending on the particular regimen of the patient. While the two or more sets of confirmatory data may be generated from the same first device, in certain embodiments, e.g., where the first device is a pharma-informatics enabled dosage, e.g., such as a smart dosage described above, the first and second devices will be different dosages, e.g., different pills. As such, embodiments of the methods include obtaining an additional set of confirmatory data from at least a third device, e.g., a second pharmaceutical dosage which is separate from the first pharmaceutical dosage, where the same second device is employed regardless of how many additional first, third, etc., devices are employed.
In addition to dosage administration data, additional data may be obtained from the patient as desired. Types of additional patient data that may be obtained include, but are not limited to: physiological parameter data, e.g., as may be obtained using any convenient sensing device, including the sensors and systems developed by some of the inventors of the assignee of the present application and described in co-owned applications and patents, as referenced below; lifestyle data, such as historical information about the patient (e.g., the patients activities on a given day, how the patient was feeling, etc.);
anticipated activities of the patient (e.g., whether or not the patient expects to exercise, whether or not the patient is feeling well, etc.); and the like.
Following obtainment of the dosage administration (i.e., confirmatory) data from the patient, e.g., where the patient may or may not be in a remote location such that obtainment of the data includes transmitting the data from a first location to a second location (for example over the internet) the data is then evaluated, e.g., using a system as reviewed below, to determine when a change in the therapeutic regimen is desired and provide a recommendation based on the determination. This step of the methods may include inputting the data into a decision support tool (e.g., of an appropriate system) and obtaining from the decision support tool a recommendation based on the confirmatory data as to whether a change is the therapeutic regimen is desirable. The dosage administration data is assessed to identify whether, based on the information received from the patient, such as compliance data, physiological parameters and lifestyle data, any modification should be made to the therapeutic regimen in order to optimize the therapeutic regimen for the patient in some way. The data may be evaluated by a health care practitioner, e.g., manually or through use of any convenient decision tool, e.g., such as the system described below, that may include a database, algorithm, actionable interface (e.g., in the form of a graphical user interface (GUI)), outcome measure, etc.
The resultant recommendation based on this evaluation step may then be employed, e.g., by a health care professional, to determine whether the therapeutic regimen should be modulated in some manner. The determination is then communicated, e.g., by a health care practitioner, to the patient, where the determination may be in the form of an indication that no change in the therapeutic regimen should be made or that a change in the therapeutic regimen should be made. As such, the health care practitioner may inform the patient that no change in therapeutic regimen should be made and that the patient should continue to follow the therapeutic regimen as previously specified to the patient.
Alternatively, the health care practitioner, following a recommendation from the evaluation step, may also forward to the patient a modified therapeutic regimen, e.g., in the form of instructions on how to change the regimen as previously specified to the patient.
The modulation of the therapeutic regimen, when made, may take a variety of different formats. For example, the modulation may take the form of a change in a pharmaceutical dosage regimen, e.g., in the amounts of active agent taken and/or the different types of active agents taken. The modulation may also take the form of a change in the activity of an implanted medical device. In addition, the modification may include lifestyle alteration recommendations, e.g., instructions to refrain from exercise, instructions to engage in exercise, instructions to modify diet, etc.
In certain embodiments, the methods may further include implementation of change in a therapeutic regimen. This implementation may be manifested in a number of different ways. For example, this implementation may be in the form of the preparation of one or more actual, physical pharmaceutical dosages that will be used in the therapeutic regimen as modified. The phrase "physical pharmaceutical dosage" refers to the actual pharmaceutical composition(s) that is administered at any given time, e.g., the actual one or more pills that are administered at a given administration event. In one form of implementation, a modified therapeutic regimen that includes a selection of different active agents in specific amounts is implemented by collecting different compositions, e.g., pills, of the active agents into a set and forwarding the set to the patient. In another form of implementation, a combination of two or more active agents in amounts specified by a therapeutic regimen as described above are combined into a single composition, and the composition is then forwarded to the patient. For example, a given modified therapeutic regimen determined as described above may call for the administration of a first amount of pharmaceutical X, a second amount pharmaceutical Y and a third amount of pharmaceutical Z. A single composition is made, e.g., by a pharmaceutical composition manufacturer in response to instructions from a system, as reviewed in greater detail below, that includes all three different pharmaceuticals in the amounts specified. The three different amounts may be present in different compartments of an inert carrier, combined in a capsule, etc., as desired. The compositions of these embodiments may be manufactured at any point along a given supply chain, e.g., at the pharmaceutical agent manufacturer level, at a distributor level, at a retail (e.g., pharmacy) level or even at the customer level, e.g., by using a home device that prepares customized formulations from stock components. Implementation may also include modulation Of the activity of an implanted device, such as a cardiac device, neurostimulatory device, etc., as may be desirable.
In certain embodiments, additional methods and systems of monitoring or tracking individual dosages or collections of dosages may be employed in conjunction, with the methods and systems of the present invention. For example, "smart package devices (i.e., pharmaceutical compliance packages) which record when a patient obtains a dosage from the package and thereby provides a proxy for the administration of the dosage to the patient may be employed.
Examples of such "smart" packaging devices and methods are found in, but not limited to: smart drug dispensers as disclosed in U.S. Pat. Nos. 4,360,125;
4,768,176; 4,768,177; 5,200,891; 5,642,731; 5,752,235 and 5,954,641.
Alternatively or in addition, RFID/barcode approaches= may be employed to provide additional confirmation or tracking information between a source of pharmaceutical dosages and patient.
Other sources of dosage compliance data include, but are not limited to, patient data recordation, e.g., via input into a compliance recordation program, etc. Dosage administration data can also include implantable medical device activity data, such as pacemaker activity data, where such activity may be monitored using any convenient system, including the system described in published PCT Application Publication No. WO 2007/028035 titled " Implantable Zero-Wire Communications System", Such additional sources of information may be employed in conjunction with the methods of invention, where desired.
FIGS. 1 and 2 provide flow charts of two different embodiments of the methods described above. In FIG. 1, the first step 110 of the exemplified method is to obtain dosage administration data, such as pharmaceutical compliance data, as reviewed above. Next, at step 120 the obtained dosage administration data is input into a therapeutic regimen evaluator, e.g., as described in greater detail below. Following step 120, the evaluator assesses at step 130 the input data to determine whether a change in the therapeutic regimen is desired. At decision box 140, if a change is the regimen is not recommended, instructions are =
forwarded to the patient to continue with the current therapeutic regimen, as shown at step 150. However, if a change in the regimen is recommended at decision box 140, a modified therapeutic regimen, e.g., in the form of a changed pharmaceutical dosage regimen and/or implanted medical device activity regimen, is developed at step 160. The developed modulated pharmaceutical dosage regimen is then forwarded to the patient at step 170. Finally, the patient proceeds by continuing to follow the prior therapeutic regimen or adopting the modified regimen, as shown at step 180.
FIG. 2 provides a modified version of the protocol shown in FIG. 1, where the method includes an implementation of the modified therapeutic regimen. In FIG. 2, the first step 210 of the exemplified method is to obtain dosage administration data, such as pharmaceutical compliance data, as reviewed above. Next, at step 220 the obtained dosage administration data is input into a therapeutic regimen evaluator, e.g., as described in greater detail below.
Following step 220, the evaluator assesses at step 230 the input data to determine whether a change in the therapeutic regimen is desired. At decision box 240, if a change is the regimen is not recommended, instructions are forwarded to the patient to continue with the current therapeutic regimen, as shown at step 250. At step 250, instructions are also sent to the patient to continue with the implementation of the prior therapeutic regimen, e.g., by taking the same pharmaceutical compositions according to the same dosing schedule, etc. However, if a change in the regimen is recommended at decision box 240, a modified therapeutic regimen, e.g., in the form of a changed pharmaceutical dosage regimen and/or implanted medical device activity regimen, is developed at step 260. The resultant modified therapeutic regimen is implemented as desired, e.g., by fabricating a physical pharmaceutical dosage (as described above) at step 270.The developed modulated pharmaceutical dosage regimen and implementation thereof is then forwarded to the patient at step 275.
Finally, the patient proceeds by continuing to follow the prior therapeutic regimen or adopting the modified regimen, along with the implementation thereof, as shown at step 280.
SYSTEMS
Also provided by the subject invention are systems that may be used to perform on or more aspects of the methods, such as the data evaluation step, e.g., as described above. In certain embodiments, the systems include a decision tool, e.g., in the form of a processor accessing a database and running an appropriate algorithm, which may take the form of a data evaluation module, which serves as a therapeutic regimen evaluator to assess the input data and provide a recommendation of whether or not a change is desired.
In the process schematically depicted in FIG. 1, a data evaluation module is employed as a therapeutic regimen evaluator to assess the input data and generate a recommendation as to whether or not the regimen should be changed. As such, the data evaluation module performs the function of receiving the input information and generating the regimen recommendation information in response thereto.
The data evaluation module employed in the subject methods may include a collection dosage administration data (e.g., compliance data) element and regimen recommendation linked data element stored in a memory, such as a database. The data elements of the module may be organized in any convenient manner. The content of the data evaluation module may be controlled using any convenient protocol. In certain embodiments, the content may be maintained by a single entity, e.g., where the entity initially creates the content and then updates the content periodically. Embodiments of the modules include updated modules in which the content of the module has been updated one or more times following its manufacture, e.g., two or more times, 5 or more times, 10 or more times, 50 or more times, 100 or more times, 1000 or more times, etc., where the updated =
content may be any of a variety of different types of information.
An embodiment of a system .that includes a data evaluation module is shown in FIG. 3. In FIG. 3, system 300 includes communications module 320 and processing module 330, where each module may be present on the same or different platforms, e.g., servers, as is known in the art. The communications module includes an input manager 322 and output manager 324 functional elements. Input manager 322 receives information, e.g., sample identifier information, from a user e.g., locally or from a remote location (such as over the Internet). Input manager 322 processes and forwards this information to the =
processing module 330. Output manager 324 provides information assembled by processing module 330, e.g., a modified therapeutic regimen, to a user. The communications module 320 may be operatively connected to a user computer 310 by communications element 315, which element provides a vehicle for a user to interact with the system 300. User computer 310, shown in FIG. 3, may be a computing device specially designed and configured to support and execute any of a multitude of different applications. Computer 310 also may be any of a variety of types of general-purpose computers such as a personal computer, network server, workstation, or other computer platform now or later developed.
As reviewed above, the systems include various functional elements that carry out specific tasks on the platforms in response to information introduced into the system by one or more users. In FIG. 3, elements 332, 334 and 336 represent three different functional elements of processing module 330.
At least one of the functional elements 332 of processing module 330 is a functionality for assessing the dosage administration data and providing a determination as to whether a change in at therapeutic dosage regimen is desired, and is conveniently referred to herein as the therapeutic regimen evaluator. Additional functional elements that may be present include, but are not limited to, elements for determining modified therapeutic regimens, etc.
In certain embodiments, the systems include one or more implantable devices, which may have therapeutic (such as electrostimulatory) and/or sensory activity.
Such sensors and systems include, but are not limited to, those described in various applications assigned to the assignee of the present application, where such applications include, but are not limited to: U.S. Patent Application No.
10/734490 published as 20040193021 titled: "Method And System For Monitoring And Treating Hemodynamic Parameters"; U.S. Patent Application No.
11/219,305 published as 20060058588 titled: "Methods And Apparatus For Tissue Activation And Monitoring"; International Application No.
PCT/US2005/046815 titled: "Implantable Addressable Segmented Electrodes";
U.S. Patent Application No. 11/324,196 titled" Implantable Accelerometer-Based Cardiac Wall Position Detector"; U.S. Patent Application No. 10/764,429, entitled =
"Method and Apparatus for Enhancing Cardiac Pacing," U.S. Patent Application No. 10/764,127, entitled "Methods and Systems for Measuring Cardiac Parameters;" U.S. Patent Application No.10/764,125, entitled "Method and System for Remote Hemodynamic Monitoring"; International Application No.
PCT/ US2005/046815 titled: "Implantable Hermetically Sealed Structures"; U.S.
Application No. 11/368,259 titled: "Fiberoptic Tissue Motion Sensor";
International Application No. PCT/US2004/041430 titled: "Implantable Pressure Sensors"; U.S.
Patent Application No. 11/249,152 entitled "Implantable Doppler Tomography System," and claiming priority to: U.S. Provisional Patent Application No.
60/617,618; International Application Serial No. PCT/USUS05/39535 titled "Cardiac Motion Characterization by Strain Gauge". ' REPRESENTATIVE EMBODIMENT
A specific representative embodiment of the above described methods and systems that may be employed in the management of a specific patient for a specific disease condition is depicted in FIG. 4. Patient 410 is a cardiovascular patient that may suffer from a variety of cardiovascular disease conditions, e.g., heart failure, hypertension, etc. Patient 410 has been implanted with a cardiovascular medical device, 420, which may include one or more of an electrical therapy element, a sensor element, including but not limited to the sensors described below, as well as a monitoring element. In certain embodiments, the monitoring element is configured to obtain, store and forward actual dosage administration information from an identifier tagged pharmaceutical composition, e.g., as described in PCT application serial no. PCT/
U82006/016370 titled "Pharma Informatics System" which was filed on April 28, 2006 and published as WO 2006/116718 on November 2, 2006; as well as the additional embodiments of such smart dosages as described in United States Provisional Application Serial Was. 60/866,581; 60/829,832; 60/887,780;
60/889,868; 60/889,870; 60/889,871; 60/894,171 and 60/894,167.
In addition, patient 410 is taking a plurality of different pharmaceuticals 430 according to a prescribed pharmaceutical dosage regimen. The pharmaceuticals 430 are identifier tagged pharmaceuticals, e.g., that include identifying IC
chips that emit a signal upon contact with a target physiological site, as described in PCT application serial no. PCT/ US2006/016370 titled "Pharma Informatics System" which was filed on April 28, 2006 and published as WO 2006/116718 on November 2, 2006; as well as the additional embodiments of such smart dosages as described in United States Provisional Application Serial Nos. 60/866,581;
60/829,832; 60/887,780; 60/889,868; 60/889,870; 60/889,871; 60/894,171 and 60/894,167.
Also shown in FIG. 4 is modem 440 that serves to relay obtained dosage information from the patient 410 to a remote location, e.g., a doctor's office. Modem 440 may be located at an in-home location, e.g., the bedside, and connected to Internet, e.g., via a wireless connection, so that data can be uploaded by the modem to the Internet and designated address thereon automatically at a predetermined daily time, e.g., when the patient is expected to be near the modem, such as at 3 AM when the patient is expected to be asleep in their bed. Of course modem 440 may be replaced by any, convenient communications element, such as a network relay station, etc. Of interest are embodiments where elements 430, 420 and 440 communicate via an implantable or topical signal receiver element (e.g., a personal health companion device) that . is configured to detect dosage administration, e.g., by a signal emitted by an identifier of a pharma informatics enabled dosage formulation, such as described in pending provisional application serial no. 60/887,780 titled "Signal Receivers for Pharma-Informatics Systems"; the disclosure of which is herein incorporated by reference.
=
Central processor 450 includes servers that include or can access a number of different information sources, e.g., patient databases, population information, sub-population information, patient specific information, etc.
The dataset or sets present .in process 450 may be raw datasets or processed in some manner, e.g., to produce subsets or populations, e.g., categories of data.
For example, compliance data from an individual patient over a period of time can be combined with data from other individuals. The combined data can be processed to identify trends or subpopulations of individuals that respond similarly under similar dosage compliance and/or other parameters, e.g., health, age, =disease stage, etc. Trends or subpopulations may be identified from the raw data using any convenient protocols, including by use of data processing algorithms that can process the data automatically and identify trends or subpopulations,. e.g., according to predetermined rules. The identified trends/subpopulations can then be employed in a variety of different ways, as desired. For example, information about a given population or groups of populations can be used by a health care professional to help inform a practitioner on the best way to treat a particular patient given that patients individual compliance data. For example, a health care professional, such as a pharmaceutical representative, can help nurse 470 and/or doctor 490 make informed therapeutic treatment regimen decisions for patent 410 by helping 470 and/or doctor 490 to interpret the particular compliance data obtained from patient 410 in the context of a given subpopulation of patients as identified and available to the representative from datasets 450. In this manner nurse 470 and/or doctor 490 actively employ the sales representative and the knowledge provided to the sales representative from datasets 450 in making individual treatment therapeutic regimen decisions for patient 410.
Laptop 460 is an embodiment of the system 300 depicted in FIG. 3 and includes a decision support tool, such as a therapeutic regimen evaluator, as reviewed above. The decision support tool has access to a variety of different types of information, such as information provided in the database exemplified as element 450, information present in the doctor's office, e.g., patient records. In certain embodiments, the decision support tool 460 can complete prescription and/or generate E-mail alerts based on data. In certain embodiments, the decision support tool 460 is linked to a wider health or hospital information system.
Shown in FIG. 4 is nurse 450 that can review patient alerts and individual web pages, contact the patient or caregiver thereof, provide advice and/or schedule visits based on recommendations generated by the decision support tool, e.g., via phone 480.
In FIG. 4, physician 490 performs one or more of the following tasks, e.g., reviews the patient log, adjusts electrical therapy, develops profiles, selects drug alternates, adjusts dosing, confirms that the current regimen is acceptable, etc. In the embodiment shown in FIG. 4, when the doctor adjusts dosing regimens, this information is forwarded to manufacturer 500: While a central manufacture is shown in FIG. 4, the dosing adjustment instructions could be forwarded to any convenient formulator, e.g., hospital or independent pharmacy, or even home formulation device. Manufacturer 500, in response to the dosing information provided by the doctor 490, makes drugs to order which are specifically tailored to the patient 410 as specified by doctor 490, e.g., within a 48 hour cycle.
The manufactured physical dosage is then forwarded directed to the patient, e.g., by express mail, as depicted by element 510.
=
PROGRAMMING
The invention also provides programming, e.g., in the form of computer program products, for use in practicing the methods. Programming according to the present invention can be recorded on computer readable media, e.g., any medium that can be read and accessed directly by a computer. Such media include, but are not limited to: magnetic storage media, such as floppy discs, hard disc storage medium, and magnetic tape; optical storage media such as CD-ROM; electrical storage media such as RAM, ROM, flash drives, micro drives;
and hybrids of these categories such as magnetic/optical storage media. One of skill in the art can readily appreciate how any of the presently known computer readable mediums can. be used to create a manufacture that includes a recording of the present programming/algorithms for carrying out the above-described methodology.
UTILITY
The present invention provides the clinician an important new tool in their therapeutic armamentarium i.e., the ability to customize therapeutic regimens in a patient specific manner. The present invention allows therapeutic regimens to be developed and modified based on actual dosage administration information, which information can be supplemented with additional dosage relevant information, such as additional physiological parameters, lifestyle information, etc. In this manner, patient specific customized optimal therapeutic regimens may be formulated by the clinician. A number of benefits result from implementation of the present invention, including but not limited to one or more of: reduced medical errors, e.g., such as those that can arise from using a standardized therapeutic regimens in a variable compliance environment; a reduction in liability, since errors will be reduced; etc.
One type of application in which the subject compositions and systems find use is in monitoring patient compliance with prescribed therapeutic regimens.
By monitoring patient compliance is meant tracking whether a patient is actually taking medication in the manner prescribed to the patient. As such, the present invention provides accurate data of when a pill has been taken and which pill has been taken. This allows the precise determination of which pill was taken at a specific point in time. Such monitoring capability assures patients are taking the prescribed medication correctly. This information avoids the potential for over prescription of medications that are not actually being taken. By example, if pain killers are intended to be administered to a patient, it is possible to verify with the present invention that the patient did in fact take those pain killers in a certain period of time. This knowledge is an important tool in limiting the illicit sale of unconsumed drugs to an unintended party. In the case of cardio vascular pills, the clinician or care giver is able to verify that the amount of the drug was taken has been taken at approximately the right point and time. Thus, the true efficacy of the drug can be accurately evaluated. Proper administration and patient compliance is especially critical in Alzheimer's, psychiatric, and alcohol aversion drugs, and in the treatment of rest home residents. In the case of accidental and other overdoses situations, the intervening clinician will be able to discern how far the ingestion has proceeded, and how many pills are involved.
In more complex embodiments of the present invention, correct, timely ingestion of the drugs will automatically trigger a prescription refill signal which is forwarded to a pharmacy data system, and in some cases the refill will be automatically delivered directly to the patient's home, or released by a device in the patient's home some period of time later. This feature is particularly valuable in patients with compromised mental capacity and/or limited physical mobility.
The invention is particularly useful in complex administration regimens, such as when multiple pharmaceuticals are being taken, and confusion is more likely to occur. The inventive pills can have multiple external layers, with only correct dosage allowing dissolution and absorption of the pharmaceutical component. Specific indicators, such as electrical conduction velocity in the heart or electrolytic levels in the blood in response to pharmaceutical can also be titrated.
In certain embodiments, a patient can be alerted when the patient is in some way non-compliant with a given treatment regimen. For example, by a sound, visual, or computer reminder, if the pharmacological regimen is not being accurately adhered to, a reminder is provided. If that reminder is not accurately responded to, the system can provide an alert to family members, caregivers, or clinicians in order to remedy the gap in treatment or overdose. The device may also automatically modify the dosage and timing of the regimen to compensate for prior non-standard dosing.
One type of application in which the subject compositions and systems find use is in tailoring therapeutic regimens based on patient compliance. In such applications, data obtained about whether a patient has or has not taken a particular dosage is employed to determine future dosages and/or timing of such dosages. In certain embodiments, data concerning patient compliance is combined with additional data, e.g., sensed physiological data, to make customized changes or modifications to a given therapeutic regimen. By example, when data about dosage compliance obtained according to the invention is used in concert with other medical sensing devices, correlation between drug delivery, batch and dosage can be correlated to a physiological response. In this manner, optimal pharma-therapeutic regimens may be formulated by the clinician. By example, cardiac stimulating drugs can be titrated to the most appropriate dosages, minimizing side effects such as cardiac muscle exhaustion and rebound effects among others, and optimizing both dosage and timing for each individual patient.
Assessment of a range of alternate medications is made possible by the present invention without resort to awaiting overt clinical sequel of treatment, many of which can be seriously adverse. By example, positive effects would be quickly ascertainable without being obscured by more random factors. Negative responses, such as changes in blood pressure, would become clearly evident as drug related or independent above background physiologic variation.
In one clinical arena, the present invention allows, in concert with other sensing devices developed by some of the present inventors, the measurement and assessment of the cardiac response to those medications. These co-employed sensing devices can be those enumerated below, among others.
Other sensing technology, e.g., as mentioned above, developed by some of the present inventors allows measurement of heart health and cardiac efficiency.
Using these tools in concert with the present inventive device, the clinician will be able to compare the response of the heart and body to the administered pharmaceutical. The data provided by the present invention can optionally be recorded over time. The recording system records synchrony or conduction velocity of a signal going through cardiac tissue and how that is mediated by the presence of a certain medication. This unique data is made possible by the present invention.
In more standard clinical environments, this unique data allows careful selection and titration of drug administration without resort to more overt physical symptoms to ascertain contraindications, efficacy, and optimal dosage levels.
The present invention provides a record for emergency room technicians or doctors when a patient is admitted to a hospital so that the patient's status can be accurately ascertained. Dosage events within the last hour or day prior to admission, and the identity of the last medication, will be immediately available:
As such, future therapeutic regimens can be made based on accurate records of patient drug medication history.
The patient monitoring capacity of the external reporting apparatus is an importation function which the inventive device can provide. When coordinated with internal or external physiologic sensing data, the device can read out the physiological response of the patient to the ingestion of medication, and then . transmit this information back to the clinician. The clinician can then modify therapy to optimal effectiveness, as indicated by the new data in response to the modified therapy, and so forth.
In more sophisticated embodiments of the present invention, the dosage adjustment function, within certain parameters, can be performed by an intelligence circuit in the apparatus. By example, for a blood pressure medication, the patient takes their blood pressure pill. 20 minutes later, the internal monitoring circuitry in the implantable device registers a deop in blood pressure. The circuitry quantifies this drop, and transmits it to this bedside apparatus. The apparatus then can adjust the dosage of the pill to optimally treat the patient.
Similarly, when the patient is connected to an IV, the dosage can be dispensed directly into the IV fluid. In certain embodiments, the closed-loop system is provided as a fully implantable device.
Current clinical practice for drug treatment optimization is considerably more limited than that which is available by use of the present inventive device.
Currently, blood pressure medication treatment is set at so many pills per day.
Such a blunt dosage regime takes a long time to optimize appropriately because the feedback loop is very slow. By contrast, with the present invention, the feedback loop of physiologic response to pharmaceutical dosage is very rapid and very efficient. Ultimately, the present invention allows tailoring the drug dosages day to day, or even more finely, to account for change in activity, change in physiological conditions in the patient, and other dosage parameter.
In more sophisticated embodiments of the present invention, physiological reactions to specific dosages and time intervals would also be continually monitored. in some embodiments, the level of drug in the blood stream is monitored, allowing for individual and time of day variations in drug metabolism.
This aspect of the present invention effectively minimizes underdosing or overdosing the controlled substances, in some cases addressing these changes before they produce external symptoms apparent to the patient or clinician.
The drug dosage can be automatically titrated so that, by example, the smallest appropriate level to quell anxiety due to pain, other physiologic reactions to pain, or provide steady or gradually diminishing blood levels of the drug would be dispensed. This feature of the present invention provides an automatic, appropriately gradual, weaning off of the drug, lessening the chance of serious addiction or severe, adverse withdrawal reactions.
KITS
Also provided are kits for practicing the subject methods. Kits may include one or more components of the systems as described above, e.g., smart packaged dosages, smart pharmaceutical compositions, receivers and modems, computer programming, etc.
The subject kits may also include instructions for how to practice the subject methods using the components of the kit. The instructions may be recorded on a suitable recording medium or substrate. For example, the instructions may be printed on a substrate, such as paper or plastic, etc. As such, the instructions may be present in the kits as a package insert, in the labeling of the container of the kit or components thereof (i.e., associated with the packaging or sub-packaging) etc. In other embodiments, the instructions are present as an electronic storage data file present on a suitable computer readable storage medium, e.g. CD-ROM, diskette, etc. In yet other embodiments, the actual instructions are not present in the kit, but means for obtaining the instructions from a remote source, e.g. via the internet, are provided. An example of this embodiment is a kit that includes a web address where the instructions can be viewed and/or from which the instructions can be downloaded. As with the instructions, this means for obtaining the instructions is recorded on a suitable substrate.
Some or all components of the subject kits may be packaged in suitable packaging to maintain sterility. In many embodiments of the subject kits, the components of the kit are packaged in a kit containment element to make a single, easily handled unit, where the kit containment element, e.g., box or analogous structure, may or may not be an airtight container, e.g., to further preserve the sterility of some or all of the components of the kit.
It is to be understood that this invention is not limited to particular embodiments described, as such may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting, since the scope of the present invention will be limited only by the appended claims.
Where a range of values is provided, it is understood that each intervening value, to the tenth of the unit of the lower limit unless the context clearly dictates otherwise, between the upper and lower limit of that range and any other stated or intervening value in that stated range, is encompassed within the invention.
The upper and lower limits of these smaller ranges may independently be included in= the smaller ranges and are also encompassed within the invention, subject to any specifically excluded limit in the stated range. Where the stated range includes one or both of the limits, ranges excluding either or both of those included limits are also included in the invention.
Certain ranges are presented herein with numerical values being preceded by the term "about." The term "about" is used herein to provide literal support for the exact number that it precedes, as well as a number that is near to or approximately the number that the term precedes. In determining whether a number is near to or approximately a specifically recited number, the near or approximating unrecited number may be a number which, in the context in which it is presented, provides the substantial equivalent of the specifically recited number.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods and materials similar or equivalent to those described herein can also be used in the practice or testing of the present invention, representative illustrative methods and materials are now described.
All publications and patents cited in this specification are herein incorporated by reference as if each individual publication or patent were specifically and individually indicated to be incorporated by reference and are incorporated herein by reference to disclose and describe the methods and/or materials in connection with which the publications are cited. The citation of any publication is for its disclosure prior to the filing date and should not be construed as an admission that the present invention is not entitled to antedate such publication by virtue of prior invention. Further, the dates of publication provided may be different from the actual publication dates which may need to be independently confirmed.
It is noted that, as used herein and in the appended claims, the singular forms "a", "an", and "the" include plural referents unless the context clearly dictates otherwise. It is further noted that the claims may be drafted to exclude any optional element. As such, this statement is intended to serve as antecedent basis for use of such exclusive terminology as "solely," "only" and the like in ' connection with the recitation of claim elements, or use of a "negative"
limitation.
As will be apparent to those of skill in the art upon reading this disclosure, each of the individual embodiments described and illustrated herein has discrete components and features which may be readily separated from or combined with the features of any of the other several embodiments without departing from the scope or spirit of the present invention. Any recited method can be carried out in the order of events recited or in any other order which is logically possible.
Although the foregoing invention has been described in some detail by way of illustration and example for purposes of clarity of understanding, it is readily apparent to those of ordinary skill in the art in light of the teachings of this invention that certain changes and modifications may be made thereto, =
Accordingly, the preceding merely illustrates the principles of the invention.
It will be appreciated that those skilled in the art will be able .to devise various arrangements which, although not explicitly described or shown herein, embody the principles of the invention, Furthermore, all examples and conditional language recited herein are principally intended to aid the reader in understanding the principles of the invention and the concepts contributed by the inventors to furthering the art, and are to be construed as being without limitation to such specifically recited examples and conditions. Moreover, all statements herein reciting principles, aspects, and embodiments of the invention as well as specific examples thereof, are intended to encompass both structural and functional equivalents thereof. Additionally, it is intended that such equivalents include both currently known equivalents and equivalents developed in the future, i.e., any elements developed that perform the same function, regardless of structure. The scope of the present invention, therefore, is not intended to be limited to the exemplary embodiments shown and = described herein.
PCT/US2005/046815 titled: "Implantable Addressable Segmented Electrodes";
U.S. Patent Application No. 11/324,196 titled" Implantable Accelerometer-Based Cardiac Wall Position Detector"; U.S. Patent Application No. 10/764,429, entitled =
"Method and Apparatus for Enhancing Cardiac Pacing," U.S. Patent Application No. 10/764,127, entitled "Methods and Systems for Measuring Cardiac Parameters;" U.S. Patent Application No.10/764,125, entitled "Method and System for Remote Hemodynamic Monitoring"; International Application No.
PCT/ US2005/046815 titled: "Implantable Hermetically Sealed Structures"; U.S.
Application No. 11/368,259 titled: "Fiberoptic Tissue Motion Sensor";
International Application No. PCT/US2004/041430 titled: "Implantable Pressure Sensors"; U.S.
Patent Application No. 11/249,152 entitled "Implantable Doppler Tomography System," and claiming priority to: U.S. Provisional Patent Application No.
60/617,618; International Application Serial No. PCT/USUS05/39535 titled "Cardiac Motion Characterization by Strain Gauge". ' REPRESENTATIVE EMBODIMENT
A specific representative embodiment of the above described methods and systems that may be employed in the management of a specific patient for a specific disease condition is depicted in FIG. 4. Patient 410 is a cardiovascular patient that may suffer from a variety of cardiovascular disease conditions, e.g., heart failure, hypertension, etc. Patient 410 has been implanted with a cardiovascular medical device, 420, which may include one or more of an electrical therapy element, a sensor element, including but not limited to the sensors described below, as well as a monitoring element. In certain embodiments, the monitoring element is configured to obtain, store and forward actual dosage administration information from an identifier tagged pharmaceutical composition, e.g., as described in PCT application serial no. PCT/
U82006/016370 titled "Pharma Informatics System" which was filed on April 28, 2006 and published as WO 2006/116718 on November 2, 2006; as well as the additional embodiments of such smart dosages as described in United States Provisional Application Serial Was. 60/866,581; 60/829,832; 60/887,780;
60/889,868; 60/889,870; 60/889,871; 60/894,171 and 60/894,167.
In addition, patient 410 is taking a plurality of different pharmaceuticals 430 according to a prescribed pharmaceutical dosage regimen. The pharmaceuticals 430 are identifier tagged pharmaceuticals, e.g., that include identifying IC
chips that emit a signal upon contact with a target physiological site, as described in PCT application serial no. PCT/ US2006/016370 titled "Pharma Informatics System" which was filed on April 28, 2006 and published as WO 2006/116718 on November 2, 2006; as well as the additional embodiments of such smart dosages as described in United States Provisional Application Serial Nos. 60/866,581;
60/829,832; 60/887,780; 60/889,868; 60/889,870; 60/889,871; 60/894,171 and 60/894,167.
Also shown in FIG. 4 is modem 440 that serves to relay obtained dosage information from the patient 410 to a remote location, e.g., a doctor's office. Modem 440 may be located at an in-home location, e.g., the bedside, and connected to Internet, e.g., via a wireless connection, so that data can be uploaded by the modem to the Internet and designated address thereon automatically at a predetermined daily time, e.g., when the patient is expected to be near the modem, such as at 3 AM when the patient is expected to be asleep in their bed. Of course modem 440 may be replaced by any, convenient communications element, such as a network relay station, etc. Of interest are embodiments where elements 430, 420 and 440 communicate via an implantable or topical signal receiver element (e.g., a personal health companion device) that . is configured to detect dosage administration, e.g., by a signal emitted by an identifier of a pharma informatics enabled dosage formulation, such as described in pending provisional application serial no. 60/887,780 titled "Signal Receivers for Pharma-Informatics Systems"; the disclosure of which is herein incorporated by reference.
=
Central processor 450 includes servers that include or can access a number of different information sources, e.g., patient databases, population information, sub-population information, patient specific information, etc.
The dataset or sets present .in process 450 may be raw datasets or processed in some manner, e.g., to produce subsets or populations, e.g., categories of data.
For example, compliance data from an individual patient over a period of time can be combined with data from other individuals. The combined data can be processed to identify trends or subpopulations of individuals that respond similarly under similar dosage compliance and/or other parameters, e.g., health, age, =disease stage, etc. Trends or subpopulations may be identified from the raw data using any convenient protocols, including by use of data processing algorithms that can process the data automatically and identify trends or subpopulations,. e.g., according to predetermined rules. The identified trends/subpopulations can then be employed in a variety of different ways, as desired. For example, information about a given population or groups of populations can be used by a health care professional to help inform a practitioner on the best way to treat a particular patient given that patients individual compliance data. For example, a health care professional, such as a pharmaceutical representative, can help nurse 470 and/or doctor 490 make informed therapeutic treatment regimen decisions for patent 410 by helping 470 and/or doctor 490 to interpret the particular compliance data obtained from patient 410 in the context of a given subpopulation of patients as identified and available to the representative from datasets 450. In this manner nurse 470 and/or doctor 490 actively employ the sales representative and the knowledge provided to the sales representative from datasets 450 in making individual treatment therapeutic regimen decisions for patient 410.
Laptop 460 is an embodiment of the system 300 depicted in FIG. 3 and includes a decision support tool, such as a therapeutic regimen evaluator, as reviewed above. The decision support tool has access to a variety of different types of information, such as information provided in the database exemplified as element 450, information present in the doctor's office, e.g., patient records. In certain embodiments, the decision support tool 460 can complete prescription and/or generate E-mail alerts based on data. In certain embodiments, the decision support tool 460 is linked to a wider health or hospital information system.
Shown in FIG. 4 is nurse 450 that can review patient alerts and individual web pages, contact the patient or caregiver thereof, provide advice and/or schedule visits based on recommendations generated by the decision support tool, e.g., via phone 480.
In FIG. 4, physician 490 performs one or more of the following tasks, e.g., reviews the patient log, adjusts electrical therapy, develops profiles, selects drug alternates, adjusts dosing, confirms that the current regimen is acceptable, etc. In the embodiment shown in FIG. 4, when the doctor adjusts dosing regimens, this information is forwarded to manufacturer 500: While a central manufacture is shown in FIG. 4, the dosing adjustment instructions could be forwarded to any convenient formulator, e.g., hospital or independent pharmacy, or even home formulation device. Manufacturer 500, in response to the dosing information provided by the doctor 490, makes drugs to order which are specifically tailored to the patient 410 as specified by doctor 490, e.g., within a 48 hour cycle.
The manufactured physical dosage is then forwarded directed to the patient, e.g., by express mail, as depicted by element 510.
=
PROGRAMMING
The invention also provides programming, e.g., in the form of computer program products, for use in practicing the methods. Programming according to the present invention can be recorded on computer readable media, e.g., any medium that can be read and accessed directly by a computer. Such media include, but are not limited to: magnetic storage media, such as floppy discs, hard disc storage medium, and magnetic tape; optical storage media such as CD-ROM; electrical storage media such as RAM, ROM, flash drives, micro drives;
and hybrids of these categories such as magnetic/optical storage media. One of skill in the art can readily appreciate how any of the presently known computer readable mediums can. be used to create a manufacture that includes a recording of the present programming/algorithms for carrying out the above-described methodology.
UTILITY
The present invention provides the clinician an important new tool in their therapeutic armamentarium i.e., the ability to customize therapeutic regimens in a patient specific manner. The present invention allows therapeutic regimens to be developed and modified based on actual dosage administration information, which information can be supplemented with additional dosage relevant information, such as additional physiological parameters, lifestyle information, etc. In this manner, patient specific customized optimal therapeutic regimens may be formulated by the clinician. A number of benefits result from implementation of the present invention, including but not limited to one or more of: reduced medical errors, e.g., such as those that can arise from using a standardized therapeutic regimens in a variable compliance environment; a reduction in liability, since errors will be reduced; etc.
One type of application in which the subject compositions and systems find use is in monitoring patient compliance with prescribed therapeutic regimens.
By monitoring patient compliance is meant tracking whether a patient is actually taking medication in the manner prescribed to the patient. As such, the present invention provides accurate data of when a pill has been taken and which pill has been taken. This allows the precise determination of which pill was taken at a specific point in time. Such monitoring capability assures patients are taking the prescribed medication correctly. This information avoids the potential for over prescription of medications that are not actually being taken. By example, if pain killers are intended to be administered to a patient, it is possible to verify with the present invention that the patient did in fact take those pain killers in a certain period of time. This knowledge is an important tool in limiting the illicit sale of unconsumed drugs to an unintended party. In the case of cardio vascular pills, the clinician or care giver is able to verify that the amount of the drug was taken has been taken at approximately the right point and time. Thus, the true efficacy of the drug can be accurately evaluated. Proper administration and patient compliance is especially critical in Alzheimer's, psychiatric, and alcohol aversion drugs, and in the treatment of rest home residents. In the case of accidental and other overdoses situations, the intervening clinician will be able to discern how far the ingestion has proceeded, and how many pills are involved.
In more complex embodiments of the present invention, correct, timely ingestion of the drugs will automatically trigger a prescription refill signal which is forwarded to a pharmacy data system, and in some cases the refill will be automatically delivered directly to the patient's home, or released by a device in the patient's home some period of time later. This feature is particularly valuable in patients with compromised mental capacity and/or limited physical mobility.
The invention is particularly useful in complex administration regimens, such as when multiple pharmaceuticals are being taken, and confusion is more likely to occur. The inventive pills can have multiple external layers, with only correct dosage allowing dissolution and absorption of the pharmaceutical component. Specific indicators, such as electrical conduction velocity in the heart or electrolytic levels in the blood in response to pharmaceutical can also be titrated.
In certain embodiments, a patient can be alerted when the patient is in some way non-compliant with a given treatment regimen. For example, by a sound, visual, or computer reminder, if the pharmacological regimen is not being accurately adhered to, a reminder is provided. If that reminder is not accurately responded to, the system can provide an alert to family members, caregivers, or clinicians in order to remedy the gap in treatment or overdose. The device may also automatically modify the dosage and timing of the regimen to compensate for prior non-standard dosing.
One type of application in which the subject compositions and systems find use is in tailoring therapeutic regimens based on patient compliance. In such applications, data obtained about whether a patient has or has not taken a particular dosage is employed to determine future dosages and/or timing of such dosages. In certain embodiments, data concerning patient compliance is combined with additional data, e.g., sensed physiological data, to make customized changes or modifications to a given therapeutic regimen. By example, when data about dosage compliance obtained according to the invention is used in concert with other medical sensing devices, correlation between drug delivery, batch and dosage can be correlated to a physiological response. In this manner, optimal pharma-therapeutic regimens may be formulated by the clinician. By example, cardiac stimulating drugs can be titrated to the most appropriate dosages, minimizing side effects such as cardiac muscle exhaustion and rebound effects among others, and optimizing both dosage and timing for each individual patient.
Assessment of a range of alternate medications is made possible by the present invention without resort to awaiting overt clinical sequel of treatment, many of which can be seriously adverse. By example, positive effects would be quickly ascertainable without being obscured by more random factors. Negative responses, such as changes in blood pressure, would become clearly evident as drug related or independent above background physiologic variation.
In one clinical arena, the present invention allows, in concert with other sensing devices developed by some of the present inventors, the measurement and assessment of the cardiac response to those medications. These co-employed sensing devices can be those enumerated below, among others.
Other sensing technology, e.g., as mentioned above, developed by some of the present inventors allows measurement of heart health and cardiac efficiency.
Using these tools in concert with the present inventive device, the clinician will be able to compare the response of the heart and body to the administered pharmaceutical. The data provided by the present invention can optionally be recorded over time. The recording system records synchrony or conduction velocity of a signal going through cardiac tissue and how that is mediated by the presence of a certain medication. This unique data is made possible by the present invention.
In more standard clinical environments, this unique data allows careful selection and titration of drug administration without resort to more overt physical symptoms to ascertain contraindications, efficacy, and optimal dosage levels.
The present invention provides a record for emergency room technicians or doctors when a patient is admitted to a hospital so that the patient's status can be accurately ascertained. Dosage events within the last hour or day prior to admission, and the identity of the last medication, will be immediately available:
As such, future therapeutic regimens can be made based on accurate records of patient drug medication history.
The patient monitoring capacity of the external reporting apparatus is an importation function which the inventive device can provide. When coordinated with internal or external physiologic sensing data, the device can read out the physiological response of the patient to the ingestion of medication, and then . transmit this information back to the clinician. The clinician can then modify therapy to optimal effectiveness, as indicated by the new data in response to the modified therapy, and so forth.
In more sophisticated embodiments of the present invention, the dosage adjustment function, within certain parameters, can be performed by an intelligence circuit in the apparatus. By example, for a blood pressure medication, the patient takes their blood pressure pill. 20 minutes later, the internal monitoring circuitry in the implantable device registers a deop in blood pressure. The circuitry quantifies this drop, and transmits it to this bedside apparatus. The apparatus then can adjust the dosage of the pill to optimally treat the patient.
Similarly, when the patient is connected to an IV, the dosage can be dispensed directly into the IV fluid. In certain embodiments, the closed-loop system is provided as a fully implantable device.
Current clinical practice for drug treatment optimization is considerably more limited than that which is available by use of the present inventive device.
Currently, blood pressure medication treatment is set at so many pills per day.
Such a blunt dosage regime takes a long time to optimize appropriately because the feedback loop is very slow. By contrast, with the present invention, the feedback loop of physiologic response to pharmaceutical dosage is very rapid and very efficient. Ultimately, the present invention allows tailoring the drug dosages day to day, or even more finely, to account for change in activity, change in physiological conditions in the patient, and other dosage parameter.
In more sophisticated embodiments of the present invention, physiological reactions to specific dosages and time intervals would also be continually monitored. in some embodiments, the level of drug in the blood stream is monitored, allowing for individual and time of day variations in drug metabolism.
This aspect of the present invention effectively minimizes underdosing or overdosing the controlled substances, in some cases addressing these changes before they produce external symptoms apparent to the patient or clinician.
The drug dosage can be automatically titrated so that, by example, the smallest appropriate level to quell anxiety due to pain, other physiologic reactions to pain, or provide steady or gradually diminishing blood levels of the drug would be dispensed. This feature of the present invention provides an automatic, appropriately gradual, weaning off of the drug, lessening the chance of serious addiction or severe, adverse withdrawal reactions.
KITS
Also provided are kits for practicing the subject methods. Kits may include one or more components of the systems as described above, e.g., smart packaged dosages, smart pharmaceutical compositions, receivers and modems, computer programming, etc.
The subject kits may also include instructions for how to practice the subject methods using the components of the kit. The instructions may be recorded on a suitable recording medium or substrate. For example, the instructions may be printed on a substrate, such as paper or plastic, etc. As such, the instructions may be present in the kits as a package insert, in the labeling of the container of the kit or components thereof (i.e., associated with the packaging or sub-packaging) etc. In other embodiments, the instructions are present as an electronic storage data file present on a suitable computer readable storage medium, e.g. CD-ROM, diskette, etc. In yet other embodiments, the actual instructions are not present in the kit, but means for obtaining the instructions from a remote source, e.g. via the internet, are provided. An example of this embodiment is a kit that includes a web address where the instructions can be viewed and/or from which the instructions can be downloaded. As with the instructions, this means for obtaining the instructions is recorded on a suitable substrate.
Some or all components of the subject kits may be packaged in suitable packaging to maintain sterility. In many embodiments of the subject kits, the components of the kit are packaged in a kit containment element to make a single, easily handled unit, where the kit containment element, e.g., box or analogous structure, may or may not be an airtight container, e.g., to further preserve the sterility of some or all of the components of the kit.
It is to be understood that this invention is not limited to particular embodiments described, as such may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting, since the scope of the present invention will be limited only by the appended claims.
Where a range of values is provided, it is understood that each intervening value, to the tenth of the unit of the lower limit unless the context clearly dictates otherwise, between the upper and lower limit of that range and any other stated or intervening value in that stated range, is encompassed within the invention.
The upper and lower limits of these smaller ranges may independently be included in= the smaller ranges and are also encompassed within the invention, subject to any specifically excluded limit in the stated range. Where the stated range includes one or both of the limits, ranges excluding either or both of those included limits are also included in the invention.
Certain ranges are presented herein with numerical values being preceded by the term "about." The term "about" is used herein to provide literal support for the exact number that it precedes, as well as a number that is near to or approximately the number that the term precedes. In determining whether a number is near to or approximately a specifically recited number, the near or approximating unrecited number may be a number which, in the context in which it is presented, provides the substantial equivalent of the specifically recited number.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods and materials similar or equivalent to those described herein can also be used in the practice or testing of the present invention, representative illustrative methods and materials are now described.
All publications and patents cited in this specification are herein incorporated by reference as if each individual publication or patent were specifically and individually indicated to be incorporated by reference and are incorporated herein by reference to disclose and describe the methods and/or materials in connection with which the publications are cited. The citation of any publication is for its disclosure prior to the filing date and should not be construed as an admission that the present invention is not entitled to antedate such publication by virtue of prior invention. Further, the dates of publication provided may be different from the actual publication dates which may need to be independently confirmed.
It is noted that, as used herein and in the appended claims, the singular forms "a", "an", and "the" include plural referents unless the context clearly dictates otherwise. It is further noted that the claims may be drafted to exclude any optional element. As such, this statement is intended to serve as antecedent basis for use of such exclusive terminology as "solely," "only" and the like in ' connection with the recitation of claim elements, or use of a "negative"
limitation.
As will be apparent to those of skill in the art upon reading this disclosure, each of the individual embodiments described and illustrated herein has discrete components and features which may be readily separated from or combined with the features of any of the other several embodiments without departing from the scope or spirit of the present invention. Any recited method can be carried out in the order of events recited or in any other order which is logically possible.
Although the foregoing invention has been described in some detail by way of illustration and example for purposes of clarity of understanding, it is readily apparent to those of ordinary skill in the art in light of the teachings of this invention that certain changes and modifications may be made thereto, =
Accordingly, the preceding merely illustrates the principles of the invention.
It will be appreciated that those skilled in the art will be able .to devise various arrangements which, although not explicitly described or shown herein, embody the principles of the invention, Furthermore, all examples and conditional language recited herein are principally intended to aid the reader in understanding the principles of the invention and the concepts contributed by the inventors to furthering the art, and are to be construed as being without limitation to such specifically recited examples and conditions. Moreover, all statements herein reciting principles, aspects, and embodiments of the invention as well as specific examples thereof, are intended to encompass both structural and functional equivalents thereof. Additionally, it is intended that such equivalents include both currently known equivalents and equivalents developed in the future, i.e., any elements developed that perform the same function, regardless of structure. The scope of the present invention, therefore, is not intended to be limited to the exemplary embodiments shown and = described herein.
Claims (31)
1. A method for managing a therapeutic regimen, said method comprising:
receiving confirmatory data from a first device associated with a patient at a second device associated with a body of the patient when the first device is ingested by the patient and is activated upon contact with an electrically conductive body fluid via completion of a partial power source, wherein the first device is electrically coupled to the body of the patient, wherein the confirmatory data represents actual ingestion of the pharmaceutical dosage of the medical composition by the patient, and wherein the confirmatory data is produced by the first device and is transmitted to the second device;
receiving at the second device physiological data indicating a response of the patient to the pharmaceutical dosage of the medical composition, wherein the second device is electrically coupled external to the body of the patient;
evaluating said confirmatory data and the physiological data to determine when a change in said therapeutic regimen is desired; and when the change is determined to be desired, indicating a modulation in said therapeutic regimen comprising indicating changing at least one of the pharmaceutical dosage of the medical composition and the dosing schedule based on the evaluation of the confirmatory data and the physiological data.
receiving confirmatory data from a first device associated with a patient at a second device associated with a body of the patient when the first device is ingested by the patient and is activated upon contact with an electrically conductive body fluid via completion of a partial power source, wherein the first device is electrically coupled to the body of the patient, wherein the confirmatory data represents actual ingestion of the pharmaceutical dosage of the medical composition by the patient, and wherein the confirmatory data is produced by the first device and is transmitted to the second device;
receiving at the second device physiological data indicating a response of the patient to the pharmaceutical dosage of the medical composition, wherein the second device is electrically coupled external to the body of the patient;
evaluating said confirmatory data and the physiological data to determine when a change in said therapeutic regimen is desired; and when the change is determined to be desired, indicating a modulation in said therapeutic regimen comprising indicating changing at least one of the pharmaceutical dosage of the medical composition and the dosing schedule based on the evaluation of the confirmatory data and the physiological data.
2. The method according to Claim 1, wherein said first and second devices are electrically coupled to said body.
3. The method according to Claim 1, wherein said confirmatory data is transmitted from said first device to said second device by establishing an electrical current between said first and second devices.
4. The method according to Claim 3, wherein said electrical current is confined among said first and second devices and said body.
5. The method according to Claim 3, wherein said electrical current is confined between said first and second devices, and wherein said first and second devices are each capacitively coupled to a conductor or ground external to said patient.
6. The method according to Claim 1, wherein said confirmatory data is obtained automatically.
7. The method according to Claim 1, wherein said first and second devices are different types of devices.
8. The method according to Claim 7, wherein said first device comprises an active agent.
9. The method according to Claim 8, wherein said second device does not comprise an active agent.
10. The method according to Claim 9, wherein said method further comprises transmitting a second set of confirmatory data from a third device to said second device.
11. The method according to Claim 10, wherein said third device comprises an active agent.
12. The method according to Claim 1, wherein said medical composition is selected from the group consisting of a drug, a vitamin, saline, infusate, a dialysate and an antacid.
13. The method according to Claim 1, wherein said first device comprises an identifier associated with a pharmaceutical composition, wherein said identifier produces said confirmatory data upon contact with a target physiological site of said patient.
14. The method according to Claim 1, wherein said evaluating comprises inputting said data into a decision support tool and obtaining from said decision support tool a recommendation based on said confirmatory data as to whether a change is said therapeutic regimen is desirable.
15. The method according to Claim 14, wherein said evaluating further comprises assessing physiological data obtained from said patient.
16. The method according to Claim 1, wherein said evaluating further comprises assessing lifestyle information obtained from said patient.
17. The method according to Claim 1, wherein said method further comprises forwarding said confirmatory data from said patient to a second location.
18. The method according to Claim 17, wherein said second location is a remote location.
19. The method according to Claim 14, further comprising determining whether a change in said therapeutic regimen is to be made.
20. The method according to Claim 19, further comprising communicating a modulated therapeutic regimen to said patient.
21. The method according to Claim 20, wherein modulating the modulated therapeutic regimen includes changing a pharmaceutical dosage regimen.
22. The method according to Claim 21, wherein changing said pharmaceutical dosage regimen includes changing an amount of a pharmaceutical agent.
23. The method according to Claim 21, wherein changing said pharmaceutical dosage regimen includes changing the use of at least one type of pharmaceutical agent.
24. The method according to Claim 19, wherein said method further comprises preparing a physical pharmaceutical dosage comprising one or more active agents and forwarding said physical pharmaceutical dosage to said patient.
25. The method according to Claim 24, wherein said physical 5 pharmaceutical dosage comprises two or more distinct compositions.
26. The method according to Claims 24, wherein said physical pharmaceutical dosage comprises a composition that includes two or more active agents.
27. The method according to Claim 26, wherein said composition is fabricated in response to said modulation of said therapeutic regimen.
28. The method according to Claim 24, wherein said composition of said physical pharmaceutical dosage comprises a dosage ingestion compliance identifier.
29. A system for managing a therapeutic regimen, said system comprising:
(a) an input manager for receiving:
confirmatory data for actual ingestion of a medical composition by a patient from a first device when the first device is ingested by the patient and is activated upon contact with an electrically conductive body fluid via completion of a partial power source, wherein the first device is electrically coupled to the body of the patient, wherein the confirmatory data represents the actual ingestion of the pharmaceutical dosage of the medical composition to by the patient; and physiological data indicating a response of the patient to the pharmaceutical dosage of the medical composition from a second device, wherein the second device is electrically coupled external to the body of the patient, wherein communication from the first device to the second device is by way of a conductive current signal through a body of the patient, and wherein the second device is electrically coupled external to the body of the patient;
(b) a processing module comprising a therapeutic regimen evaluator configured to assess a therapeutic regimen based on received confirmatory data and the physiological data to determine whether a change in a therapeutic regimen is desirable and provide a recommendation based on said determination; and (c) an output manager for providing said recommendation to a user, wherein the recommendation indicates a change in at least one of the pharmaceutical dosage of the medical composition and the dosing schedule.
(a) an input manager for receiving:
confirmatory data for actual ingestion of a medical composition by a patient from a first device when the first device is ingested by the patient and is activated upon contact with an electrically conductive body fluid via completion of a partial power source, wherein the first device is electrically coupled to the body of the patient, wherein the confirmatory data represents the actual ingestion of the pharmaceutical dosage of the medical composition to by the patient; and physiological data indicating a response of the patient to the pharmaceutical dosage of the medical composition from a second device, wherein the second device is electrically coupled external to the body of the patient, wherein communication from the first device to the second device is by way of a conductive current signal through a body of the patient, and wherein the second device is electrically coupled external to the body of the patient;
(b) a processing module comprising a therapeutic regimen evaluator configured to assess a therapeutic regimen based on received confirmatory data and the physiological data to determine whether a change in a therapeutic regimen is desirable and provide a recommendation based on said determination; and (c) an output manager for providing said recommendation to a user, wherein the recommendation indicates a change in at least one of the pharmaceutical dosage of the medical composition and the dosing schedule.
30. A method for managing a therapeutic regimen, said method comprising:
inputting confirmatory data received from said patient into a system according to Claim 29; and obtaining a recommendation from said system for treating said patient according to said recommendation.
inputting confirmatory data received from said patient into a system according to Claim 29; and obtaining a recommendation from said system for treating said patient according to said recommendation.
31. A computer program product comprising a computer readable storage medium having a computer program stored thereon, wherein said computer program, when loaded onto a computer, operates said computer to:
receive confirmatory data for actual ingestion of a pharmaceutical dosage of a medical composition to a patient from a first device, when the first device is ingested by the patient and is activated upon contact with an electrically conductive body fluid via completion of a partial power source, wherein the first device is electrically coupled to the body of the patient;
receive physiological data indicating a response of the patient to the pharmaceutical dosage of the medical composition, by a second device, wherein the second device is electrically coupled external to the body of the patient;
assess a therapeutic regimen of said patient in view of said confirmatory data and the physiological data to determine whether a change in a therapeutic regimen is desirable and provide a recommendation based on said determination; and provide said recommendation to a user, wherein the recommendation indicates a change in at least one of the pharmaceutical dosage of the medical composition and a dosing schedule based on the assessment.
receive confirmatory data for actual ingestion of a pharmaceutical dosage of a medical composition to a patient from a first device, when the first device is ingested by the patient and is activated upon contact with an electrically conductive body fluid via completion of a partial power source, wherein the first device is electrically coupled to the body of the patient;
receive physiological data indicating a response of the patient to the pharmaceutical dosage of the medical composition, by a second device, wherein the second device is electrically coupled external to the body of the patient;
assess a therapeutic regimen of said patient in view of said confirmatory data and the physiological data to determine whether a change in a therapeutic regimen is desirable and provide a recommendation based on said determination; and provide said recommendation to a user, wherein the recommendation indicates a change in at least one of the pharmaceutical dosage of the medical composition and a dosing schedule based on the assessment.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74625006P | 2006-05-02 | 2006-05-02 | |
US60/746,250 | 2006-05-02 | ||
PCT/US2007/010688 WO2007130491A2 (en) | 2006-05-02 | 2007-05-02 | Patient customized therapeutic regimens |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2650920A1 CA2650920A1 (en) | 2007-11-15 |
CA2650920C true CA2650920C (en) | 2016-10-18 |
Family
ID=38668294
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2650920A Active CA2650920C (en) | 2006-05-02 | 2007-05-02 | Patient customized therapeutic regimens |
Country Status (8)
Country | Link |
---|---|
US (3) | US8956287B2 (en) |
EP (2) | EP3367386A1 (en) |
JP (3) | JP2009544338A (en) |
KR (2) | KR20140018439A (en) |
CN (2) | CN105468895A (en) |
CA (1) | CA2650920C (en) |
IL (1) | IL195052A (en) |
WO (1) | WO2007130491A2 (en) |
Families Citing this family (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
US8802183B2 (en) | 2005-04-28 | 2014-08-12 | Proteus Digital Health, Inc. | Communication system with enhanced partial power source and method of manufacturing same |
US8912908B2 (en) | 2005-04-28 | 2014-12-16 | Proteus Digital Health, Inc. | Communication system with remote activation |
EP3827747A1 (en) | 2005-04-28 | 2021-06-02 | Otsuka Pharmaceutical Co., Ltd. | Pharma-informatics system |
US8836513B2 (en) | 2006-04-28 | 2014-09-16 | Proteus Digital Health, Inc. | Communication system incorporated in an ingestible product |
US9198608B2 (en) | 2005-04-28 | 2015-12-01 | Proteus Digital Health, Inc. | Communication system incorporated in a container |
US8730031B2 (en) | 2005-04-28 | 2014-05-20 | Proteus Digital Health, Inc. | Communication system using an implantable device |
US8543420B2 (en) * | 2007-09-19 | 2013-09-24 | Fresenius Medical Care Holdings, Inc. | Patient-specific content delivery methods and systems |
JP2009544338A (en) | 2006-05-02 | 2009-12-17 | プロテウス バイオメディカル インコーポレイテッド | Treatment regimen customized to the patient |
US8054140B2 (en) | 2006-10-17 | 2011-11-08 | Proteus Biomedical, Inc. | Low voltage oscillator for medical devices |
KR101611240B1 (en) | 2006-10-25 | 2016-04-11 | 프로테우스 디지털 헬스, 인코포레이티드 | Controlled activation ingestible identifier |
WO2008063626A2 (en) | 2006-11-20 | 2008-05-29 | Proteus Biomedical, Inc. | Active signal processing personal health signal receivers |
MY165532A (en) | 2007-02-01 | 2018-04-02 | Proteus Digital Health Inc | Ingestible event marker systems |
EP2111661B1 (en) | 2007-02-14 | 2017-04-12 | Proteus Digital Health, Inc. | In-body power source having high surface area electrode |
EP2063771A1 (en) | 2007-03-09 | 2009-06-03 | Proteus Biomedical, Inc. | In-body device having a deployable antenna |
WO2008112577A1 (en) | 2007-03-09 | 2008-09-18 | Proteus Biomedical, Inc. | In-body device having a multi-directional transmitter |
US8540632B2 (en) | 2007-05-24 | 2013-09-24 | Proteus Digital Health, Inc. | Low profile antenna for in body device |
EP4011289A1 (en) | 2007-09-25 | 2022-06-15 | Otsuka Pharmaceutical Co., Ltd. | In-body device with virtual dipole signal amplification |
US20090135886A1 (en) | 2007-11-27 | 2009-05-28 | Proteus Biomedical, Inc. | Transbody communication systems employing communication channels |
JP2011513865A (en) | 2008-03-05 | 2011-04-28 | プロテウス バイオメディカル インコーポレイテッド | Multi-mode communication ingestible event marker and system and method of using the same |
WO2010005877A2 (en) | 2008-07-08 | 2010-01-14 | Proteus Biomedical, Inc. | Ingestible event marker data framework |
AU2013273755B2 (en) * | 2008-07-08 | 2015-10-29 | Proteus Digital Health, Inc. | Ingestible event marker data framework |
US8057679B2 (en) * | 2008-07-09 | 2011-11-15 | Baxter International Inc. | Dialysis system having trending and alert generation |
KR101214453B1 (en) | 2008-08-13 | 2012-12-24 | 프로테우스 디지털 헬스, 인코포레이티드 | Ingestible circuitry |
US9439566B2 (en) | 2008-12-15 | 2016-09-13 | Proteus Digital Health, Inc. | Re-wearable wireless device |
US9659423B2 (en) | 2008-12-15 | 2017-05-23 | Proteus Digital Health, Inc. | Personal authentication apparatus system and method |
TWI503101B (en) | 2008-12-15 | 2015-10-11 | Proteus Digital Health Inc | Body-associated receiver and method |
WO2013012869A1 (en) | 2011-07-21 | 2013-01-24 | Proteus Digital Health, Inc. | Mobile communication device, system, and method |
CN102341031A (en) | 2009-01-06 | 2012-02-01 | 普罗秋斯生物医学公司 | Ingestion-related biofeedback and personalized medical therapy method and system |
US8698741B1 (en) | 2009-01-16 | 2014-04-15 | Fresenius Medical Care Holdings, Inc. | Methods and apparatus for medical device cursor control and touchpad-based navigation |
GB2480965B (en) | 2009-03-25 | 2014-10-08 | Proteus Digital Health Inc | Probablistic pharmacokinetic and pharmacodynamic modeling |
MX2011011506A (en) | 2009-04-28 | 2012-05-08 | Proteus Biomedical Inc | Highly reliable ingestible event markers and methods for using the same. |
US9149423B2 (en) | 2009-05-12 | 2015-10-06 | Proteus Digital Health, Inc. | Ingestible event markers comprising an ingestible component |
US8822225B2 (en) | 2009-10-01 | 2014-09-02 | Fresenius Medical Care Holdings, Inc. | Method of calculating a phosphorus-protein ratio |
TWI517050B (en) | 2009-11-04 | 2016-01-11 | 普羅托斯數位健康公司 | System for supply chain management |
US8632485B2 (en) * | 2009-11-05 | 2014-01-21 | Fresenius Medical Care Holdings, Inc. | Patient treatment and monitoring systems and methods |
US10799117B2 (en) | 2009-11-05 | 2020-10-13 | Fresenius Medical Care Holdings, Inc. | Patient treatment and monitoring systems and methods with cause inferencing |
AU2011210648B2 (en) | 2010-02-01 | 2014-10-16 | Otsuka Pharmaceutical Co., Ltd. | Data gathering system |
WO2011127252A2 (en) | 2010-04-07 | 2011-10-13 | Proteus Biomedical, Inc. | Miniature ingestible device |
TWI557672B (en) | 2010-05-19 | 2016-11-11 | 波提亞斯數位康健公司 | Computer system and computer-implemented method to track medication from manufacturer to a patient, apparatus and method for confirming delivery of medication to a patient, patient interface device |
US9585810B2 (en) | 2010-10-14 | 2017-03-07 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter-chamber diffuser |
US8585604B2 (en) | 2010-10-29 | 2013-11-19 | Medtronic, Inc. | Integrated patient care |
EP2642983A4 (en) | 2010-11-22 | 2014-03-12 | Proteus Digital Health Inc | Ingestible device with pharmaceutical product |
US9439599B2 (en) | 2011-03-11 | 2016-09-13 | Proteus Digital Health, Inc. | Wearable personal body associated device with various physical configurations |
WO2013006643A1 (en) | 2011-07-06 | 2013-01-10 | The Parkinson's Institute | Compositions and methods for treatment of symptoms in parkinson's disease patients |
US9756874B2 (en) | 2011-07-11 | 2017-09-12 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
US9073206B2 (en) | 2012-06-21 | 2015-07-07 | Omnicare, Inc. | Methods and apparatus for automated filling of packagings with medications |
CA2828430C (en) | 2011-07-11 | 2019-03-05 | Omnicare Inc. | Methods and apparatus for filling of packagings with medications |
WO2015112603A1 (en) | 2014-01-21 | 2015-07-30 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
US9443061B2 (en) | 2011-08-16 | 2016-09-13 | Elwha Llc | Devices and methods for recording information on a subject's body |
US9286615B2 (en) * | 2011-08-16 | 2016-03-15 | Elwha Llc | Devices and methods for recording information on a subject's body |
US9772270B2 (en) | 2011-08-16 | 2017-09-26 | Elwha Llc | Devices and methods for recording information on a subject's body |
US9235683B2 (en) | 2011-11-09 | 2016-01-12 | Proteus Digital Health, Inc. | Apparatus, system, and method for managing adherence to a regimen |
KR101306983B1 (en) * | 2011-12-22 | 2013-09-10 | 연세대학교 산학협력단 | Apparatus and method for prescription of chemotheraphy |
US20150019138A1 (en) * | 2012-03-30 | 2015-01-15 | Baxter Corporation Englewood | Systems and methods for determining ingredient amounts for preparations for administration to patients |
TW201424689A (en) | 2012-07-23 | 2014-07-01 | Proteus Digital Health Inc | Techniques for manufacturing ingestible event markers comprising an ingestible component |
US9268909B2 (en) | 2012-10-18 | 2016-02-23 | Proteus Digital Health, Inc. | Apparatus, system, and method to adaptively optimize power dissipation and broadcast power in a power source for a communication device |
KR101916418B1 (en) * | 2012-11-29 | 2018-11-08 | 삼성전자주식회사 | Method and apparatus for reducing power consumption of receiver |
US10105487B2 (en) | 2013-01-24 | 2018-10-23 | Chrono Therapeutics Inc. | Optimized bio-synchronous bioactive agent delivery system |
US11149123B2 (en) | 2013-01-29 | 2021-10-19 | Otsuka Pharmaceutical Co., Ltd. | Highly-swellable polymeric films and compositions comprising the same |
WO2014121257A1 (en) * | 2013-02-04 | 2014-08-07 | Sano Informed Prescribing, Llc | Prescription decision support system and method using comprehensive multiplex drug monitoring |
US10262112B2 (en) | 2013-02-04 | 2019-04-16 | Precera Bioscience, Inc. | Prescription decision support system and method using comprehensive multiplex drug monitoring |
US9805163B1 (en) | 2013-03-13 | 2017-10-31 | Wellframe, Inc. | Apparatus and method for improving compliance with a therapeutic regimen |
JP6498177B2 (en) | 2013-03-15 | 2019-04-10 | プロテウス デジタル ヘルス, インコーポレイテッド | Identity authentication system and method |
US10175376B2 (en) | 2013-03-15 | 2019-01-08 | Proteus Digital Health, Inc. | Metal detector apparatus, system, and method |
JP6511439B2 (en) | 2013-06-04 | 2019-05-15 | プロテウス デジタル ヘルス, インコーポレイテッド | Systems, devices, and methods for data collection and outcome assessment |
US9796576B2 (en) | 2013-08-30 | 2017-10-24 | Proteus Digital Health, Inc. | Container with electronically controlled interlock |
MX356850B (en) | 2013-09-20 | 2018-06-15 | Proteus Digital Health Inc | Methods, devices and systems for receiving and decoding a signal in the presence of noise using slices and warping. |
US9577864B2 (en) | 2013-09-24 | 2017-02-21 | Proteus Digital Health, Inc. | Method and apparatus for use with received electromagnetic signal at a frequency not known exactly in advance |
US10084880B2 (en) | 2013-11-04 | 2018-09-25 | Proteus Digital Health, Inc. | Social media networking based on physiologic information |
US20150279178A1 (en) * | 2014-03-31 | 2015-10-01 | Elwha Llc | Quantified-self machines and circuits reflexively related to fabricator, big-data analytics and user interfaces, and supply machines and circuits |
US9922307B2 (en) | 2014-03-31 | 2018-03-20 | Elwha Llc | Quantified-self machines, circuits and interfaces reflexively related to food |
US10318123B2 (en) | 2014-03-31 | 2019-06-11 | Elwha Llc | Quantified-self machines, circuits and interfaces reflexively related to food fabricator machines and circuits |
US10127361B2 (en) | 2014-03-31 | 2018-11-13 | Elwha Llc | Quantified-self machines and circuits reflexively related to kiosk systems and associated food-and-nutrition machines and circuits |
US10704944B2 (en) | 2014-09-14 | 2020-07-07 | Becton, Dickinson And Company | System and method for capturing dose information |
US10971260B2 (en) | 2014-09-14 | 2021-04-06 | Becton, Dickinson And Company | System and method for capturing dose information |
NZ762886A (en) * | 2014-09-29 | 2022-02-25 | Zogenix International Ltd | Control system for control of distribution of medication |
WO2016064908A1 (en) * | 2014-10-25 | 2016-04-28 | Sumner Bluffs, Llc. | Systems and methods for determining compliance and efficacy of a dosing regimen for a pharmaceutical agent |
AU2016211330A1 (en) | 2015-01-28 | 2017-08-03 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
JP2018511127A (en) | 2015-03-12 | 2018-04-19 | クロノ セラピューティクス インコーポレイテッドChrono Therapeutics Inc. | Craving input and support system |
US11051543B2 (en) | 2015-07-21 | 2021-07-06 | Otsuka Pharmaceutical Co. Ltd. | Alginate on adhesive bilayer laminate film |
US20170084195A1 (en) * | 2015-09-17 | 2017-03-23 | Susan Roberts | Method and System for Improving Weight Management Interventions by Assessing Variability in Serial Weight Measurements |
US9928348B2 (en) | 2015-12-21 | 2018-03-27 | At&T Intellectual Property I, L.P. | Medicine dispensing system |
US11488714B2 (en) | 2016-03-23 | 2022-11-01 | HealthPals, Inc. | Machine learning for collaborative medical data metrics |
US11185282B2 (en) * | 2016-05-20 | 2021-11-30 | Appmed Inc. | System and method for monitoring and identifying posology efficacy for an an individual |
CN109843149B (en) | 2016-07-22 | 2020-07-07 | 普罗秋斯数字健康公司 | Electromagnetic sensing and detection of ingestible event markers |
JP2019535377A (en) | 2016-10-26 | 2019-12-12 | プロテウス デジタル ヘルス, インコーポレイテッド | Method for producing capsules with ingestible event markers |
JP2020503950A (en) | 2017-01-06 | 2020-02-06 | クロノ セラピューティクス インコーポレイテッドChrono Therapeutics Inc. | Device and method for transdermal drug delivery |
JP6904036B2 (en) * | 2017-04-19 | 2021-07-14 | 株式会社湯山製作所 | Therapy management system, therapy management program |
US11017892B1 (en) | 2017-09-11 | 2021-05-25 | Massachusetts Mutual Life Insurance Company | System and method for ingestible drug delivery |
US20210035672A1 (en) * | 2018-04-05 | 2021-02-04 | University Of Maryland, Baltimore | Method and apparatus for individualized administration of medicaments for delivery within a therapeutic range |
AU2019279884A1 (en) | 2018-05-29 | 2020-12-10 | Morningside Venture Investments Limited | Drug delivery methods and systems |
CA3107769A1 (en) * | 2018-07-26 | 2020-01-30 | Eli Lilly And Company | Systems and methods for remote prescription of medication-dosing regimens |
US11464410B2 (en) * | 2018-10-12 | 2022-10-11 | Masimo Corporation | Medical systems and methods |
WO2020234883A1 (en) * | 2019-05-21 | 2020-11-26 | Syqe Medical Ltd. | Substance delivery planning system |
US11684299B2 (en) | 2019-12-17 | 2023-06-27 | Mahana Therapeutics, Inc. | Method and system for remotely monitoring the psychological state of an application user using machine learning-based models |
US11610663B2 (en) | 2020-05-29 | 2023-03-21 | Mahana Therapeutics, Inc. | Method and system for remotely identifying and monitoring anomalies in the physical and/or psychological state of an application user using average physical activity data associated with a set of people other than the user |
CN111899844B (en) * | 2020-09-28 | 2021-11-23 | 平安科技(深圳)有限公司 | Sample generation method and device, server and storage medium |
JP2022068527A (en) * | 2020-10-22 | 2022-05-10 | 株式会社Cureapp | System, electronic device, method, and program for adjusting amount of medication intake |
WO2022086784A1 (en) * | 2020-10-22 | 2022-04-28 | Mahana Therapeutics, Inc. | Methods and systems for treating gastrointestinal and inflammatory health conditions using prescription digital therapeutics in combination with other therapies |
US20230107786A1 (en) * | 2021-10-05 | 2023-04-06 | Bradford RABIN | Methods and systems for electronically adjusting a dosing pattern of a patient undergoing a medical regimen |
Family Cites Families (1096)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB775071A (en) | 1954-08-03 | 1957-05-22 | The Chloride Electrical Storage Co. Ltd. | Improvements in primary electric batteries |
US3345989A (en) | 1963-11-05 | 1967-10-10 | Gen Electric | Implantable power source employing a body fluid as an electrolyte |
GB1140684A (en) | 1965-08-31 | 1969-01-22 | Rotax Ltd | Switching circuits |
US3799802A (en) | 1966-06-28 | 1974-03-26 | F Schneble | Plated through hole printed circuit boards |
US3409721A (en) | 1967-09-15 | 1968-11-05 | Neomed Lab Inc | Oral dosage system effective to control the reproduction cycle |
US3607788A (en) | 1967-11-20 | 1971-09-21 | Robert J Adolph | Liquid electrode material |
US3589943A (en) | 1968-08-29 | 1971-06-29 | Gen Electric | Electrochemical battery |
US3642008A (en) * | 1968-09-25 | 1972-02-15 | Medical Plastics Inc | Ground electrode and test circuit |
US3679480A (en) | 1969-05-08 | 1972-07-25 | Dow Chemical Co | Electrical cell assembly |
US3682160A (en) | 1969-10-16 | 1972-08-08 | Matsushita Electric Ind Co Ltd | Physiological signal transmitter for use inside the body |
US3628669A (en) | 1969-12-22 | 1971-12-21 | Owens Corning Fiberglass Corp | Semipermeable membranes |
US3719183A (en) * | 1970-03-05 | 1973-03-06 | H Schwartz | Method for detecting blockage or insufficiency of pancreatic exocrine function |
US3727616A (en) | 1971-06-15 | 1973-04-17 | Gen Dynamics Corp | Electronic system for the stimulation of biological systems |
US3837339A (en) | 1972-02-03 | 1974-09-24 | Whittaker Corp | Blood glucose level monitoring-alarm system and method therefor |
US3825016A (en) * | 1972-02-28 | 1974-07-23 | Devices Ltd | Implantable cardiac pacemaker with battery voltage-responsive rate |
US3828766A (en) | 1972-08-14 | 1974-08-13 | Jet Medical Prod Inc | Disposable medical electrode |
US3989050A (en) | 1972-09-19 | 1976-11-02 | Gilbert Buchalter | Process for utilizing certain gel compositions for electrical stimulation |
US3944064A (en) * | 1973-10-26 | 1976-03-16 | Alza Corporation | Self-monitored device for releasing agent at functional rate |
US4106348A (en) | 1974-02-20 | 1978-08-15 | U.S. Philips Corporation | Device for examination by means of ultrasonic vibrations |
US3893111A (en) | 1974-03-14 | 1975-07-01 | Albert Albert F | System and method for remote monitoring of animal temperature |
US3967202A (en) | 1974-07-25 | 1976-06-29 | Northern Illinois Gas Company | Data transmission system including an RF transponder for generating a broad spectrum of intelligence bearing sidebands |
US4090752A (en) | 1974-10-07 | 1978-05-23 | Baxter Travenol Laboratories, Inc. | Diagnostic electrode assembly |
ZA755785B (en) * | 1974-10-07 | 1976-08-25 | Baxter Laboratories Inc | Diagnostic electrode assembly |
US4077397A (en) * | 1974-10-07 | 1978-03-07 | Baxter Travenol Laboratories, Inc. | Diagnostic electrode assembly |
US4062750A (en) | 1974-12-18 | 1977-12-13 | James Francis Butler | Thin film electrochemical electrode and cell |
FR2330368A1 (en) | 1975-11-04 | 1977-06-03 | Anvar | METHOD AND DEVICE FOR IN VIVO MEASUREMENT OF THE DEGREE OF BONE CONSOLIDATION |
US4055178A (en) | 1976-03-10 | 1977-10-25 | Harrigan Roy Major | Drug delivery device for preventing contact of undissolved drug with the stomach lining |
US4017856A (en) | 1976-03-10 | 1977-04-12 | Westinghouse Electric Corporation | Self-calibrating microwave transponder |
US4075070A (en) | 1976-06-09 | 1978-02-21 | Ppg Industries, Inc. | Electrode material |
US4129125A (en) | 1976-12-27 | 1978-12-12 | Camin Research Corp. | Patient monitoring system |
US4105023A (en) * | 1977-01-19 | 1978-08-08 | American Optical Corporation | Pacemaker artifact suppression in coronary monitoring |
GB1594214A (en) | 1977-01-21 | 1981-07-30 | Cardio Tech | Body electrodes |
US4082087A (en) | 1977-02-07 | 1978-04-04 | Isis Medical Instruments | Body contact electrode structure for deriving electrical signals due to physiological activity |
JPS5475284A (en) | 1977-11-29 | 1979-06-15 | Asahi Chemical Ind | Threeeterminal magnetic reluctance effect element |
US4239046A (en) | 1978-09-21 | 1980-12-16 | Ong Lincoln T | Medical electrode |
US4345588A (en) | 1979-04-23 | 1982-08-24 | Northwestern University | Method of delivering a therapeutic agent to a target capillary bed |
US4281664A (en) | 1979-05-14 | 1981-08-04 | Medtronic, Inc. | Implantable telemetry transmission system for analog and digital data |
US4269189A (en) | 1979-07-09 | 1981-05-26 | Consolidated Medical Equipment Inc. | Skin conducting electrode assembly |
DE2928477C3 (en) | 1979-07-14 | 1982-04-15 | Battelle-Institut E.V., 6000 Frankfurt | Device for the release of substances at defined locations in the digestive tract |
US4360125A (en) | 1980-03-10 | 1982-11-23 | Medtronic, Inc. | Medication inventory device |
US4331654A (en) | 1980-06-13 | 1982-05-25 | Eli Lilly And Company | Magnetically-localizable, biodegradable lipid microspheres |
US4578061A (en) | 1980-10-28 | 1986-03-25 | Lemelson Jerome H | Injection catheter and method |
US4418697A (en) | 1981-08-17 | 1983-12-06 | Francine Tama | Electrode attachment method |
US4494950A (en) * | 1982-01-19 | 1985-01-22 | The Johns Hopkins University | Plural module medication delivery system |
US4439196A (en) * | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
JPS5997924U (en) | 1982-12-22 | 1984-07-03 | 宮崎製陶株式会社 | Stacking straightening device for ceramic green molded products |
GB8315308D0 (en) | 1983-06-03 | 1983-07-06 | Jenkins W N | Arc deposition of metal onto substrate |
DE3335301C2 (en) | 1983-06-25 | 1985-05-02 | Udo 8500 Nürnberg Simon | Drug container |
US4564363A (en) * | 1983-07-13 | 1986-01-14 | Smithkline Beckman Corporation | Delayed action assembly |
GB8322007D0 (en) | 1983-08-16 | 1983-09-21 | Wellcome Found | Pharmaceutical delivery system |
US4749575A (en) | 1983-10-03 | 1988-06-07 | Bio-Dar Ltd. | Microencapsulated medicament in sweet matrix |
US4559950A (en) | 1983-11-25 | 1985-12-24 | Graphic Controls Corporation | Disposable biomedical and diagnostic electrode |
US5000957A (en) | 1984-03-19 | 1991-03-19 | Alza Corporation | Dispenser comprising hydrophilic osmopolymer |
JPS6117949A (en) | 1984-07-05 | 1986-01-25 | Katsuo Ebara | Solid ph sensor |
US4768177A (en) | 1984-07-06 | 1988-08-30 | Kehr Bruce A | Method of and apparatus for alerting a patient to take medication |
US4768176A (en) | 1984-07-06 | 1988-08-30 | Kehr Bruce A | Apparatus for alerting a patient to take medication |
GB8422876D0 (en) | 1984-09-11 | 1984-10-17 | Secr Defence | Silicon implant devices |
FR2571603B1 (en) | 1984-10-11 | 1989-01-06 | Ascher Gilles | PORTABLE ELECTROCARDIOGRAM RECORDER |
JPS6172712U (en) | 1984-10-12 | 1986-05-17 | ||
US4618533A (en) | 1984-11-30 | 1986-10-21 | Millipore Corporation | Porous membrane having hydrophilic surface and process |
US4681111A (en) | 1985-04-05 | 1987-07-21 | Siemens-Pacesetter, Inc. | Analog and digital telemetry system for an implantable device |
US4654165A (en) | 1985-04-16 | 1987-03-31 | Micro Tracers, Inc. | Microingredient containing tracer |
US4767627A (en) | 1985-05-29 | 1988-08-30 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
US4763659A (en) | 1985-08-21 | 1988-08-16 | Spring Creek Institute, Inc. | Dry electrode system for detection of biopotentials |
US4669479A (en) | 1985-08-21 | 1987-06-02 | Spring Creek Institute, Inc. | Dry electrode system for detection of biopotentials |
US4635641A (en) * | 1985-10-16 | 1987-01-13 | Murray Electronics Associates Limited | Multi-element electrode |
US4663250A (en) | 1986-03-12 | 1987-05-05 | Institute Of Gas Technology | Reduction of electrode dissolution |
US4725997A (en) | 1986-08-22 | 1988-02-16 | Aprex Corporation | Contingent dosing device |
US4784162A (en) | 1986-09-23 | 1988-11-15 | Advanced Medical Technologies | Portable, multi-channel, physiological data monitoring system |
US4896261A (en) | 1986-11-24 | 1990-01-23 | Motorola Inc. | System for scheduling serial message transmission on a bus which is adoptable for rescheduling prioritized messages using a doubly-linked list |
DE3713251C2 (en) | 1987-04-18 | 1996-04-11 | Mannesmann Kienzle Gmbh | Device for the transmission and storage of energy and information in a card-shaped, mobile data carrier |
US4876093A (en) | 1987-07-02 | 1989-10-24 | Alza Corporation | Dispenser with dispersing member for delivering beneficial agent |
DE3723310A1 (en) | 1987-07-15 | 1989-01-26 | John Urquhart | PHARMACEUTICAL PREPARATION AND METHOD FOR THE PRODUCTION THEREOF |
JPH01285247A (en) | 1988-05-12 | 1989-11-16 | Olympus Optical Co Ltd | Medical capsule |
US5002772A (en) | 1988-05-31 | 1991-03-26 | Pfizer Inc. | Gastric retention system for controlled drug release |
CA1327838C (en) | 1988-06-13 | 1994-03-15 | Fred Zacouto | Implantable device to prevent blood clotting disorders |
US4975230A (en) | 1988-06-17 | 1990-12-04 | Vapor Technologies Inc. | Method of making an open pore structure |
US5245332A (en) | 1988-06-22 | 1993-09-14 | Iedsco Oy | Programmable memory for an encoding system |
US4844076A (en) | 1988-08-26 | 1989-07-04 | The Johns Hopkins University | Ingestible size continuously transmitting temperature monitoring pill |
US4871974A (en) | 1988-12-23 | 1989-10-03 | International Business Machines, Corp. | Coherent phase shift keyed demodulator |
US5000997A (en) * | 1989-02-06 | 1991-03-19 | The Budd Company | Method for making a painted part and part made thereby |
DE58908945D1 (en) | 1989-04-10 | 1995-03-09 | Pacesetter Ab | Implantable medical device with means for the telemetric transmission of data. |
CA2016517C (en) | 1989-05-11 | 1999-01-12 | Dale R. Shackle | Solid state electrochemical cell having microroughened current collector |
US5281287A (en) | 1989-07-21 | 1994-01-25 | Iomed, Inc. | Method of making a hydratable bioelectrode |
US4987897A (en) | 1989-09-18 | 1991-01-29 | Medtronic, Inc. | Body bus medical device communication system |
JPH0646539Y2 (en) | 1989-11-09 | 1994-11-30 | ヤコー通信工業株式会社 | Powder paint tank |
US5200891A (en) | 1990-01-17 | 1993-04-06 | Bruce A. Kehr | Electronic medication dispensing method |
US5642731A (en) | 1990-01-17 | 1997-07-01 | Informedix, Inc. | Method of and apparatus for monitoring the management of disease |
US5752235A (en) | 1990-01-17 | 1998-05-12 | Informedix, Inc. | Electronic medication monitoring and dispensing method |
JP2552927B2 (en) | 1990-01-26 | 1996-11-13 | 三菱電機株式会社 | Demodulator for π / 4 shift QPSK signal |
US5468222A (en) * | 1990-05-03 | 1995-11-21 | Mayo Foundation For Medical Education & Research | Process for determining drug taper schedules |
US6749122B1 (en) | 1990-05-25 | 2004-06-15 | Broadcom Corporation | Multi-level hierarchial radio-frequency system communication system |
US6359872B1 (en) | 1997-10-28 | 2002-03-19 | Intermec Ip Corp. | Wireless personal local area network |
US5167626A (en) | 1990-10-02 | 1992-12-01 | Glaxo Inc. | Medical capsule device actuated by radio-frequency (RF) signal |
JP3203680B2 (en) * | 1991-05-28 | 2001-08-27 | ソニー株式会社 | Vertical synchronization processing circuit |
US5395366A (en) | 1991-05-30 | 1995-03-07 | The State University Of New York | Sampling capsule and process |
US5279607A (en) | 1991-05-30 | 1994-01-18 | The State University Of New York | Telemetry capsule and process |
US6605046B1 (en) | 1991-06-03 | 2003-08-12 | Del Mar Medical Systems, Llc | Ambulatory physio-kinetic monitor with envelope enclosure |
EP0526166A2 (en) | 1991-07-29 | 1993-02-03 | Albert L. Dessertine | Patient compliance monitoring method and system |
CA2074889C (en) | 1991-07-30 | 1997-12-09 | Motoya Iwasaki | Carrier frequency error detector capable of accurately detecting a carrier frequency error |
GB9123638D0 (en) | 1991-11-07 | 1992-01-02 | Magill Alan R | Apparel & fabric & devices suitable for health monitoring applications |
US5176626A (en) | 1992-01-15 | 1993-01-05 | Wilson-Cook Medical, Inc. | Indwelling stent |
JPH05228128A (en) | 1992-02-25 | 1993-09-07 | Olympus Optical Co Ltd | Capsule for medical treatment |
JPH05245215A (en) * | 1992-03-03 | 1993-09-24 | Terumo Corp | Heart pace maker |
EP0636009B1 (en) | 1992-04-03 | 2000-11-29 | Micromedical Industries Limited | system for physiological monitoring |
US5263481A (en) | 1992-05-21 | 1993-11-23 | Jens Axelgaard | Electrode system with disposable gel |
US5283136A (en) | 1992-06-03 | 1994-02-01 | Ramot University Authority For Applied Research And Industrial Development Ltd. | Rechargeable batteries |
US5318557A (en) | 1992-07-13 | 1994-06-07 | Elan Medical Technologies Limited | Medication administering device |
US5261402A (en) | 1992-07-20 | 1993-11-16 | Graphic Controls Corporation | Snapless, tabless, disposable medical electrode with low profile |
JP3454525B2 (en) | 1992-07-23 | 2003-10-06 | 三洋電機株式会社 | Micromachines and power systems in micromachines |
US5428961A (en) | 1992-07-21 | 1995-07-04 | Sanyo Electric Co., Ltd. | Micromachines |
US5338625A (en) | 1992-07-29 | 1994-08-16 | Martin Marietta Energy Systems, Inc. | Thin film battery and method for making same |
US7758503B2 (en) | 1997-01-27 | 2010-07-20 | Lynn Lawrence A | Microprocessor system for the analysis of physiologic and financial datasets |
US5412372A (en) | 1992-09-21 | 1995-05-02 | Medical Microsystems, Inc. | Article dispenser for monitoring dispensing times |
JP3214159B2 (en) | 1993-01-22 | 2001-10-02 | 三菱電機株式会社 | Carrier detector |
US5757326A (en) | 1993-03-29 | 1998-05-26 | Seiko Epson Corporation | Slot antenna device and wireless apparatus employing the antenna device |
US5406945A (en) | 1993-05-24 | 1995-04-18 | Ndm Acquisition Corp. | Biomedical electrode having a secured one-piece conductive terminal |
US5394882A (en) * | 1993-07-21 | 1995-03-07 | Respironics, Inc. | Physiological monitoring system |
US5458141A (en) | 1993-08-04 | 1995-10-17 | Quinton Instrument Company | Abrasive skin electrode |
US5443461A (en) | 1993-08-31 | 1995-08-22 | Alza Corporation | Segmented device for simultaneous delivery of multiple beneficial agents |
DE4329898A1 (en) | 1993-09-04 | 1995-04-06 | Marcus Dr Besson | Wireless medical diagnostic and monitoring device |
US5402793A (en) | 1993-11-19 | 1995-04-04 | Advanced Technology Laboratories, Inc. | Ultrasonic transesophageal probe for the imaging and diagnosis of multiple scan planes |
SE512207C2 (en) | 1993-11-26 | 2000-02-14 | Meditelligence Ab | Drug storage device |
US6390088B1 (en) | 1993-12-13 | 2002-05-21 | Boehringer Ingelheim Kg | Aerosol inhaler |
US5476488A (en) | 1993-12-15 | 1995-12-19 | Pacesetter, Inc. | Telemetry system power control for implantable medical devices |
US6206829B1 (en) | 1996-07-12 | 2001-03-27 | First Opinion Corporation | Computerized medical diagnostic and treatment advice system including network access |
DE69526371T2 (en) | 1994-03-21 | 2002-11-28 | Dusa Pharmaceuticals Inc | PLASTER AND CONTROL DEVICE FOR PHOTODYNAMIC THERAPY FROM DERMAL INJURIES |
US5925066A (en) | 1995-10-26 | 1999-07-20 | Galvani, Ltd. | Atrial arrythmia sensor with drug and electrical therapy control apparatus |
US5600548A (en) * | 1994-08-11 | 1997-02-04 | Sundstrand Corporation | DC content control for an inverter |
IE70735B1 (en) | 1994-08-15 | 1996-12-11 | Elan Med Tech | Orally administrable delivery device |
DE9414065U1 (en) | 1994-08-31 | 1994-11-03 | Roehm Gmbh | Thermoplastic plastic for pharmaceutical casings soluble in intestinal juice |
JP3376462B2 (en) | 1994-09-19 | 2003-02-10 | 日本光電工業株式会社 | Signal transmission device and biological signal measurement device |
IL111396A (en) | 1994-10-25 | 1997-07-13 | Ness Neuromuscular Electrical Stimulation Systems Ltd | Electrode system |
US5551953A (en) | 1994-10-31 | 1996-09-03 | Alza Corporation | Electrotransport system with remote telemetry link |
US5485841A (en) | 1995-02-14 | 1996-01-23 | Univ Mcgill | Ultrasonic lung tissue assessment |
US5778882A (en) * | 1995-02-24 | 1998-07-14 | Brigham And Women's Hospital | Health monitoring system |
US6374670B1 (en) | 1995-03-13 | 2002-04-23 | University Of Washington | Non-invasive gut motility monitor |
US5845265A (en) | 1995-04-26 | 1998-12-01 | Mercexchange, L.L.C. | Consignment nodes |
US5645063A (en) | 1995-06-05 | 1997-07-08 | Quinton Instrument Company | Skin electrode having multiple conductive center members |
US5738708A (en) | 1995-06-07 | 1998-04-14 | The Regents Of The University Of California Office Of Technology Transfer | Composite metal membrane |
US6083248A (en) | 1995-06-23 | 2000-07-04 | Medtronic, Inc. | World wide patient location and data telemetry system for implantable medical devices |
US5720771A (en) | 1995-08-02 | 1998-02-24 | Pacesetter, Inc. | Method and apparatus for monitoring physiological data from an implantable medical device |
USD377983S (en) | 1995-09-13 | 1997-02-11 | Mohamed Sabri | Cardiac monitor |
US5802467A (en) | 1995-09-28 | 1998-09-01 | Innovative Intelcom Industries | Wireless and wired communications, command, control and sensing system for sound and/or data transmission and reception |
WO1997014112A1 (en) | 1995-10-11 | 1997-04-17 | Motorola Inc. | Remotely powered electronic tag and associated exciter/reader and related method |
US6076016A (en) | 1995-10-19 | 2000-06-13 | Feierbach; Gary F. | Galvanic transdermal conduction communication system and method |
GB9522872D0 (en) | 1995-11-08 | 1996-01-10 | Oxford Medical Ltd | Improvements relating to physiological monitoring |
US8092224B2 (en) | 1995-11-22 | 2012-01-10 | James A. Jorasch | Systems and methods for improved health care compliance |
SE9504258D0 (en) | 1995-11-28 | 1995-11-28 | Pacesetter Ab | Device and method for generating a synthesized ECG |
US6090489A (en) | 1995-12-22 | 2000-07-18 | Toto, Ltd. | Method for photocatalytically hydrophilifying surface and composite material with photocatalytically hydrophilifiable surface |
US5596302A (en) | 1996-01-17 | 1997-01-21 | Lucent Technologies Inc. | Ring oscillator using even numbers of differential stages with current mirrors |
US5868136A (en) * | 1996-02-20 | 1999-02-09 | Axelgaard Manufacturing Co. Ltd. | Medical electrode |
US20010044588A1 (en) | 1996-02-22 | 2001-11-22 | Mault James R. | Monitoring system |
US5833603A (en) | 1996-03-13 | 1998-11-10 | Lipomatrix, Inc. | Implantable biosensing transponder |
UA48221C2 (en) | 1996-04-01 | 2002-08-15 | Валєрій Івановіч Кобозєв | Electrical gastro-intestinal tract stimulator |
US5965629A (en) | 1996-04-19 | 1999-10-12 | Korea Institute Of Science And Technology | Process for modifying surfaces of materials, and materials having surfaces modified thereby |
GB9608268D0 (en) | 1996-04-22 | 1996-06-26 | Robertson James L | Blister pack |
US5864578A (en) | 1996-04-29 | 1999-01-26 | Golden Bridge Technology, Inc. | Matched filter-based handoff method and apparatus |
JPH09330159A (en) | 1996-06-11 | 1997-12-22 | Omron Corp | Data processor, game controller data processing method and game processing method |
US5800421A (en) | 1996-06-12 | 1998-09-01 | Lemelson; Jerome H. | Medical devices using electrosensitive gels |
JP3636826B2 (en) | 1996-07-01 | 2005-04-06 | 積水化学工業株式会社 | Bioelectrical impedance measuring device |
WO1998007364A1 (en) | 1996-08-16 | 1998-02-26 | Roche Diagnostics Gmbh | Monitoring system for the regular intake of a medicament |
AU724490B2 (en) | 1996-08-29 | 2000-09-21 | Jagotec Ag | Tablet with controlled release of alfuzosin hydrochloride |
US5792048A (en) | 1996-09-03 | 1998-08-11 | Schaefer; Guenter | Indentification pill with integrated microchip: smartpill, smartpill with integrated microchip and microprocessor for medical analyses and a smartpill, smartbox, smartplague, smartbadge or smartplate for luggage control on commercial airliners |
US5963132A (en) | 1996-10-11 | 1999-10-05 | Avid Indentification Systems, Inc. | Encapsulated implantable transponder |
US6394953B1 (en) | 2000-02-25 | 2002-05-28 | Aspect Medical Systems, Inc. | Electrode array system for measuring electrophysiological signals |
US5954641A (en) | 1997-09-08 | 1999-09-21 | Informedix, Inc. | Method, apparatus and operating system for managing the administration of medication and medical treatment regimens |
US6364834B1 (en) | 1996-11-13 | 2002-04-02 | Criticare Systems, Inc. | Method and system for remotely monitoring multiple medical parameters in an integrated medical monitoring system |
US8734339B2 (en) | 1996-12-16 | 2014-05-27 | Ip Holdings, Inc. | Electronic skin patch for real time monitoring of cardiac activity and personal health management |
US5928142A (en) | 1996-12-17 | 1999-07-27 | Ndm, Inc. | Biomedical electrode having a disposable electrode and a reusable leadwire adapter that interfaces with a standard leadwire connector |
US5974124A (en) | 1997-01-21 | 1999-10-26 | Med Graph | Method and system aiding medical diagnosis and treatment |
US6122351A (en) | 1997-01-21 | 2000-09-19 | Med Graph, Inc. | Method and system aiding medical diagnosis and treatment |
DE69841846D1 (en) | 1997-03-17 | 2010-09-30 | Adidas Ag | INFORMATION RECONDITIONING SYSTEM FOR PHYSIOLOGICAL SIGNALS |
AU6943698A (en) | 1997-03-31 | 1998-10-22 | Telecom Medical, Inc. | Patient monitoring apparatus |
US5981166A (en) | 1997-04-23 | 1999-11-09 | Pharmaseq, Inc. | Screening of soluble chemical compounds for their pharmacological properties utilizing transponders |
DE19717023C2 (en) | 1997-04-23 | 2003-02-06 | Micronas Gmbh | Device for treating malignant, tumorous tissue areas |
US6288629B1 (en) | 1997-05-23 | 2001-09-11 | Intermec Ip Corp. | Method of using write—ok flag for radio frequency (RF) transponders (RF Tags) |
US5921925A (en) | 1997-05-30 | 1999-07-13 | Ndm, Inc. | Biomedical electrode having a disposable electrode and a reusable leadwire adapter that interfaces with a standard leadwire connector |
GB2327591A (en) | 1997-07-24 | 1999-02-03 | Nestle Sa | Reduced fat chocolate |
US5984875A (en) | 1997-08-22 | 1999-11-16 | Innotek Pet Products, Inc. | Ingestible animal temperature sensor |
US5862808A (en) | 1997-08-26 | 1999-01-26 | Cigar Savor Enterprises Llc | Cigar punch |
US5917346A (en) | 1997-09-12 | 1999-06-29 | Alfred E. Mann Foundation | Low power current to frequency converter circuit for use in implantable sensors |
US6018734A (en) * | 1997-09-29 | 2000-01-25 | Triada, Ltd. | Multi-dimensional pattern analysis |
US6409674B1 (en) | 1998-09-24 | 2002-06-25 | Data Sciences International, Inc. | Implantable sensor with wireless communication |
KR100729585B1 (en) | 1997-10-31 | 2007-06-19 | 아로노위츠, 잭 엘 | Reflectometer |
JPH11195415A (en) | 1997-11-05 | 1999-07-21 | Matsushita Electric Ind Co Ltd | Nonaqueous electrolyte battery and its manufacture |
US5948227A (en) | 1997-12-17 | 1999-09-07 | Caliper Technologies Corp. | Methods and systems for performing electrophoretic molecular separations |
US6856832B1 (en) | 1997-12-25 | 2005-02-15 | Nihon Kohden Corporation | Biological signal detection apparatus Holter electrocardiograph and communication system of biological signals |
JP3697629B2 (en) | 1999-09-13 | 2005-09-21 | 日本光電工業株式会社 | Communication system for biological signals |
US20040015132A1 (en) * | 1998-01-06 | 2004-01-22 | Eric Brown | Method for improving patient compliance with a medical program |
GB9801363D0 (en) | 1998-01-22 | 1998-03-18 | Danbiosyst Uk | Novel dosage form |
US6097927A (en) | 1998-01-27 | 2000-08-01 | Symbix, Incorporated | Active symbolic self design method and apparatus |
US6009350A (en) | 1998-02-06 | 1999-12-28 | Medtronic, Inc. | Implant device telemetry antenna |
US6038464A (en) * | 1998-02-09 | 2000-03-14 | Axelgaard Manufacturing Co., Ltd. | Medical electrode |
US6275476B1 (en) | 1998-02-19 | 2001-08-14 | Micron Technology, Inc. | Method of addressing messages and communications system |
US7542878B2 (en) | 1998-03-03 | 2009-06-02 | Card Guard Scientific Survival Ltd. | Personal health monitor and a method for health monitoring |
US6141592A (en) | 1998-03-06 | 2000-10-31 | Intermedics Inc. | Data transmission using a varying electric field |
US6024699A (en) * | 1998-03-13 | 2000-02-15 | Healthware Corporation | Systems, methods and computer program products for monitoring, diagnosing and treating medical conditions of remotely located patients |
US6579231B1 (en) | 1998-03-27 | 2003-06-17 | Mci Communications Corporation | Personal medical monitoring unit and system |
US6091975A (en) | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
US6949816B2 (en) | 2003-04-21 | 2005-09-27 | Motorola, Inc. | Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same |
EP1077634B1 (en) | 1998-05-13 | 2003-07-30 | Cygnus, Inc. | Monitoring of physiological analytes |
AU4094599A (en) | 1998-05-21 | 1999-12-06 | Telecom Medical, Inc. | Patient monitoring apparatus |
TW406018B (en) | 1998-05-21 | 2000-09-21 | Elan Corp Plc | Improved adhesive system for medical devices |
US6477424B1 (en) | 1998-06-19 | 2002-11-05 | Medtronic, Inc. | Medical management system integrated programming apparatus for communication with an implantable medical device |
US6704602B2 (en) | 1998-07-02 | 2004-03-09 | Medtronic, Inc. | Implanted medical device/external medical instrument communication utilizing surface electrodes |
JP4401026B2 (en) | 1998-07-20 | 2010-01-20 | コギンズ,ジョージ | Devices for monitoring physiological parameters and biofeedback |
US7209787B2 (en) | 1998-08-05 | 2007-04-24 | Bioneuronics Corporation | Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease |
US7548787B2 (en) * | 2005-08-03 | 2009-06-16 | Kamilo Feher | Medical diagnostic and communication system |
US6703047B2 (en) | 2001-02-02 | 2004-03-09 | Incept Llc | Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use |
US6558320B1 (en) | 2000-01-20 | 2003-05-06 | Medtronic Minimed, Inc. | Handheld personal data assistant (PDA) with a medical device and method of using the same |
US6333699B1 (en) | 1998-08-28 | 2001-12-25 | Marathon Oil Company | Method and apparatus for determining position in a pipe |
JP2002524124A (en) | 1998-09-04 | 2002-08-06 | ウルフ リサーチ プロプライエタリー リミテッド | Medical implantation system |
EP1112558A4 (en) | 1998-09-11 | 2002-07-31 | Key Trak Inc | Object tracking system with non-contact object detection and identification |
AU5651699A (en) * | 1998-09-18 | 2000-04-10 | Hitachi Maxell, Ltd. | Noncontact communication semiconductor device |
FI116957B (en) * | 1998-10-29 | 2006-04-13 | Nokia Corp | The method of communication between the wireless device and the electronic device and the communication device |
US6708060B1 (en) * | 1998-11-09 | 2004-03-16 | Transpharma Ltd. | Handheld apparatus and method for transdermal drug delivery and analyte extraction |
AU1832800A (en) | 1998-11-25 | 2000-06-19 | Ball Semiconductor Inc. | Method of and system for identifying medical products |
US6217744B1 (en) | 1998-12-18 | 2001-04-17 | Peter Crosby | Devices for testing fluid |
US6663846B1 (en) | 1998-12-21 | 2003-12-16 | Mccombs Candace | Devices and methods for monitoring drug therapy compliance |
US6115636A (en) | 1998-12-22 | 2000-09-05 | Medtronic, Inc. | Telemetry for implantable devices using the body as an antenna |
JP3414381B2 (en) | 1998-12-22 | 2003-06-09 | セイコーエプソン株式会社 | Power feeding device, power receiving device, power transmission system, power transmission method, portable device, and clock device |
US6269058B1 (en) | 1999-01-04 | 2001-07-31 | Texas Instruments Incorporated | Wide capture range circuitry |
US6117077A (en) | 1999-01-22 | 2000-09-12 | Del Mar Medical Systems, Llc | Long-term, ambulatory physiological recorder |
US6358202B1 (en) * | 1999-01-25 | 2002-03-19 | Sun Microsystems, Inc. | Network for implanted computer devices |
US8636648B2 (en) | 1999-03-01 | 2014-01-28 | West View Research, Llc | Endoscopic smart probe |
US6285897B1 (en) | 1999-04-07 | 2001-09-04 | Endonetics, Inc. | Remote physiological monitoring system |
US6494829B1 (en) | 1999-04-15 | 2002-12-17 | Nexan Limited | Physiological sensor array |
US6290646B1 (en) | 1999-04-16 | 2001-09-18 | Cardiocom | Apparatus and method for monitoring and communicating wellness parameters of ambulatory patients |
US6200265B1 (en) * | 1999-04-16 | 2001-03-13 | Medtronic, Inc. | Peripheral memory patch and access method for use with an implantable medical device |
US6755783B2 (en) | 1999-04-16 | 2004-06-29 | Cardiocom | Apparatus and method for two-way communication in a device for monitoring and communicating wellness parameters of ambulatory patients |
AU4601500A (en) | 1999-05-18 | 2000-12-05 | Sonometrics Corporation | System for incorporating sonomicrometer functions into medical instruments and implantable biomedical devices |
DE69913743T2 (en) * | 1999-05-25 | 2004-10-07 | Medicotest As Olstykke | SKIN ELECTRODE |
EP1852836A3 (en) | 1999-05-26 | 2011-03-30 | Johnson Controls Technology Company | Wireless communications system and method |
US6366206B1 (en) | 1999-06-02 | 2002-04-02 | Ball Semiconductor, Inc. | Method and apparatus for attaching tags to medical and non-medical devices |
EP1060704A3 (en) | 1999-06-18 | 2002-09-18 | Agilent Technologies, Inc. (a Delaware corporation) | Multi-parameter capability transmitter for wireless telemetry systems |
JP3402267B2 (en) | 1999-06-23 | 2003-05-06 | ソニーケミカル株式会社 | Electronic element mounting method |
DE19929328A1 (en) | 1999-06-26 | 2001-01-04 | Daimlerchrysler Aerospace Ag | Device for long-term medical monitoring of people |
US6287252B1 (en) | 1999-06-30 | 2001-09-11 | Monitrak | Patient monitor |
US6804558B2 (en) | 1999-07-07 | 2004-10-12 | Medtronic, Inc. | System and method of communicating between an implantable medical device and a remote computer system or health care provider |
US6307468B1 (en) * | 1999-07-20 | 2001-10-23 | Avid Identification Systems, Inc. | Impedance matching network and multidimensional electromagnetic field coil for a transponder interrogator |
HN2000000165A (en) * | 1999-08-05 | 2001-07-09 | Dimensional Foods Corp | EDIBLE HOLOGRAPHIC PRODUCTS, PARTICULARLY PHARMACEUTICALS, AND METHODS AND APPLIANCES FOR PRODUCERS. |
US6428809B1 (en) | 1999-08-18 | 2002-08-06 | Microdose Technologies, Inc. | Metering and packaging of controlled release medication |
US6206702B1 (en) | 1999-08-24 | 2001-03-27 | Deborah A. Hayden | Methods and devices for treating unilateral neglect |
JP3876573B2 (en) | 1999-09-20 | 2007-01-31 | カシオ計算機株式会社 | Net game apparatus and caricature image display control method |
US6526034B1 (en) * | 1999-09-21 | 2003-02-25 | Tantivy Communications, Inc. | Dual mode subscriber unit for short range, high rate and long range, lower rate data communications |
US6533733B1 (en) | 1999-09-24 | 2003-03-18 | Ut-Battelle, Llc | Implantable device for in-vivo intracranial and cerebrospinal fluid pressure monitoring |
US6990082B1 (en) * | 1999-11-08 | 2006-01-24 | Intel Corporation | Wireless apparatus having a transceiver equipped to support multiple wireless communication protocols |
KR100739357B1 (en) | 1999-09-30 | 2007-07-18 | 소니 가부시끼 가이샤 | Recording apparatus, recording method and recording media |
AU778361B2 (en) | 1999-10-07 | 2004-12-02 | La Mont, Llc | Physiological signal monitoring apparatus and method |
US6852084B1 (en) | 2000-04-28 | 2005-02-08 | Peter V. Boesen | Wireless physiological pressure sensor and transmitter with capability of short range radio frequency transmissions |
US6882881B1 (en) | 1999-10-19 | 2005-04-19 | The Johns Hopkins University | Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders |
US7076437B1 (en) | 1999-10-29 | 2006-07-11 | Victor Levy | Process for consumer-directed diagnostic and health care information |
US6426863B1 (en) | 1999-11-25 | 2002-07-30 | Lithium Power Technologies, Inc. | Electrochemical capacitor |
US6612984B1 (en) | 1999-12-03 | 2003-09-02 | Kerr, Ii Robert A. | System and method for collecting and transmitting medical data |
WO2001045793A1 (en) | 1999-12-21 | 2001-06-28 | Medtronic, Inc. | System for dynamic remote networking with implantable medical devices |
GB9930000D0 (en) | 1999-12-21 | 2000-02-09 | Phaeton Research Ltd | An ingestible device |
JP3850611B2 (en) | 1999-12-28 | 2006-11-29 | 三菱電機株式会社 | Timing regenerator and demodulator using the same |
US6294999B1 (en) | 1999-12-29 | 2001-09-25 | Becton, Dickinson And Company | Systems and methods for monitoring patient compliance with medication regimens |
US6471645B1 (en) | 1999-12-30 | 2002-10-29 | Medtronic, Inc. | Communications system for an implantable device and a drug dispenser |
US6961448B2 (en) | 1999-12-30 | 2005-11-01 | Medtronic, Inc. | User authentication in medical device systems |
US8002700B2 (en) | 1999-12-30 | 2011-08-23 | Medtronic, Inc. | Communications system for an implantable medical device and a delivery device |
US8049597B1 (en) | 2000-01-10 | 2011-11-01 | Ensign Holdings, Llc | Systems and methods for securely monitoring an individual |
US6980958B1 (en) * | 2000-01-11 | 2005-12-27 | Zycare, Inc. | Apparatus and methods for monitoring and modifying anticoagulation therapy of remotely located patients |
EP1119137B1 (en) | 2000-01-20 | 2006-08-16 | Lucent Technologies Inc. | Interoperability for bluetooth/IEEE 802.11 |
AR026148A1 (en) | 2000-01-21 | 2003-01-29 | Osmotica Argentina S A | OSMOTIC DEVICE WITH PREFORMED PASSAGE THAT INCREASES SIZE |
US6368190B1 (en) | 2000-01-26 | 2002-04-09 | Agere Systems Guardian Corp. | Electrochemical mechanical planarization apparatus and method |
JP3839212B2 (en) | 2000-02-04 | 2006-11-01 | 三菱電機株式会社 | Timing reproduction apparatus and demodulator |
US7039453B2 (en) | 2000-02-08 | 2006-05-02 | Tarun Mullick | Miniature ingestible capsule |
KR100800040B1 (en) | 2000-03-08 | 2008-01-31 | 기븐 이미징 리미티드 | A capsule for in vivo imaging |
US7366675B1 (en) | 2000-03-10 | 2008-04-29 | Walker Digital, Llc | Methods and apparatus for increasing, monitoring and/or rewarding a party's compliance with a schedule for taking medicines |
US6526315B1 (en) * | 2000-03-17 | 2003-02-25 | Tanita Corporation | Portable bioelectrical impedance measuring instrument |
DE10014588A1 (en) | 2000-03-27 | 2001-10-04 | Basf Ag | Sustained-release oral dosage form that floats in gastric fluid includes a blend of polyvinyl acetate and polyvinylpyrrolidone |
GB0007617D0 (en) | 2000-03-29 | 2000-05-17 | Psion Dacom Plc | A short range radio transceiver device |
US6757523B2 (en) | 2000-03-31 | 2004-06-29 | Zeus Wireless, Inc. | Configuration of transmit/receive switching in a transceiver |
US6622050B2 (en) | 2000-03-31 | 2003-09-16 | Medtronic, Inc. | Variable encryption scheme for data transfer between medical devices and related data management systems |
US6922592B2 (en) | 2000-04-04 | 2005-07-26 | Medtronic, Inc. | Implantable medical device controlled by a non-invasive physiological data measurement device |
US6654638B1 (en) | 2000-04-06 | 2003-11-25 | Cardiac Pacemakers, Inc. | Ultrasonically activated electrodes |
US6441747B1 (en) | 2000-04-18 | 2002-08-27 | Motorola, Inc. | Wireless system protocol for telemetry monitoring |
US6496705B1 (en) | 2000-04-18 | 2002-12-17 | Motorola Inc. | Programmable wireless electrode system for medical monitoring |
US6561975B1 (en) | 2000-04-19 | 2003-05-13 | Medtronic, Inc. | Method and apparatus for communicating with medical device systems |
US6836862B1 (en) | 2000-04-24 | 2004-12-28 | 3Com Corporation | Method of indicating wireless connection integrity |
US20010039503A1 (en) | 2000-04-28 | 2001-11-08 | Chan Bryan K. | Method and system for managing chronic disease and wellness online |
WO2001086894A2 (en) | 2000-05-08 | 2001-11-15 | Transilica, Inc. | Transmit-only and receive-only bluetooth apparatus and method |
US6432292B1 (en) | 2000-05-16 | 2002-08-13 | Metallic Power, Inc. | Method of electrodepositing metal on electrically conducting particles |
US7860583B2 (en) * | 2004-08-25 | 2010-12-28 | Carefusion 303, Inc. | System and method for dynamically adjusting patient therapy |
US6544174B2 (en) | 2000-05-19 | 2003-04-08 | Welch Allyn Protocol, Inc. | Patient monitoring system |
US6680923B1 (en) * | 2000-05-23 | 2004-01-20 | Calypso Wireless, Inc. | Communication system and method |
US20030130714A1 (en) | 2000-05-29 | 2003-07-10 | Brian Nielsen | Electrode for establishing electrical contact with the skin |
US7485095B2 (en) | 2000-05-30 | 2009-02-03 | Vladimir Shusterman | Measurement and analysis of trends in physiological and/or health data |
IL163684A0 (en) | 2000-05-31 | 2005-12-18 | Given Imaging Ltd | Measurement of electrical characteristics of tissue |
US7261690B2 (en) | 2000-06-16 | 2007-08-28 | Bodymedia, Inc. | Apparatus for monitoring health, wellness and fitness |
GB0014855D0 (en) * | 2000-06-16 | 2000-08-09 | Isis Innovation | Combining measurements from different sensors |
US20060122474A1 (en) | 2000-06-16 | 2006-06-08 | Bodymedia, Inc. | Apparatus for monitoring health, wellness and fitness |
US6605038B1 (en) | 2000-06-16 | 2003-08-12 | Bodymedia, Inc. | System for monitoring health, wellness and fitness |
US7689437B1 (en) | 2000-06-16 | 2010-03-30 | Bodymedia, Inc. | System for monitoring health, wellness and fitness |
GB0014854D0 (en) * | 2000-06-16 | 2000-08-09 | Isis Innovation | System and method for acquiring data |
US6505077B1 (en) | 2000-06-19 | 2003-01-07 | Medtronic, Inc. | Implantable medical device with external recharging coil electrical connection |
US7009946B1 (en) * | 2000-06-22 | 2006-03-07 | Intel Corporation | Method and apparatus for multi-access wireless communication |
GB0016561D0 (en) | 2000-07-05 | 2000-08-23 | Rolls Royce Plc | Health monitoring |
US6961285B2 (en) | 2000-07-07 | 2005-11-01 | Ddms Holdings L.L.C. | Drug delivery management system |
US6411567B1 (en) | 2000-07-07 | 2002-06-25 | Mark A. Niemiec | Drug delivery management system |
EP1301123B1 (en) | 2000-07-19 | 2004-12-08 | Medicotest A/S | A skin electrode with a by-pass element |
WO2002007598A1 (en) | 2000-07-24 | 2002-01-31 | Motorola, Inc. | Ingestible electronic capsule |
US6564079B1 (en) | 2000-07-27 | 2003-05-13 | Ckm Diagnostics, Inc. | Electrode array and skin attachment system for noninvasive nerve location and imaging device |
US7558965B2 (en) | 2000-08-04 | 2009-07-07 | First Data Corporation | Entity authentication in electronic communications by providing verification status of device |
JP4428835B2 (en) | 2000-08-09 | 2010-03-10 | 昭和電工株式会社 | Magnetic recording medium and method for manufacturing the same |
US8036731B2 (en) | 2001-01-22 | 2011-10-11 | Spectrum Dynamics Llc | Ingestible pill for diagnosing a gastrointestinal tract |
KR20020015907A (en) | 2000-08-23 | 2002-03-02 | 정병렬 | A method and system of a fitness using a game control for a beating of the heart |
WO2002017223A1 (en) | 2000-08-24 | 2002-02-28 | Koninklijke Philips Electronics N.V. | Identification transponder |
US20020026111A1 (en) * | 2000-08-28 | 2002-02-28 | Neil Ackerman | Methods of monitoring glucose levels in a subject and uses thereof |
US7685005B2 (en) * | 2000-08-29 | 2010-03-23 | Medtronic, Inc. | Medical device systems implemented network scheme for remote patient management |
DE60102331T2 (en) * | 2000-09-08 | 2005-03-17 | Matsushita Electric Works, Ltd., Kadoma | Data transmission system using a human body as a signal transmission path |
US6720923B1 (en) | 2000-09-14 | 2004-04-13 | Stata Labs, Llc | Antenna design utilizing a cavity architecture for global positioning system (GPS) applications |
US6572636B1 (en) | 2000-09-19 | 2003-06-03 | Robert Sean Hagen | Pulse sensing patch and associated methods |
JP4489922B2 (en) | 2000-09-22 | 2010-06-23 | 株式会社日立国際電気 | Demodulation method |
AU2001292946A1 (en) * | 2000-09-26 | 2002-04-08 | Advantage 3D Llc | Method and system for generation, storage and distribution of omni-directional object views |
AU2002224453A1 (en) | 2000-10-11 | 2002-04-22 | Microchips, Inc. | Microchip reservoir devices and facilitated corrosion of electrodes |
US7024248B2 (en) | 2000-10-16 | 2006-04-04 | Remon Medical Technologies Ltd | Systems and methods for communicating with implantable devices |
JP4154559B2 (en) | 2000-10-19 | 2008-09-24 | ニプロ株式会社 | Medical diagnostic system and diagnostic processing method thereof |
US7857626B2 (en) | 2000-10-23 | 2010-12-28 | Toly Christopher C | Medical physiological simulator including a conductive elastomer layer |
US6738671B2 (en) | 2000-10-26 | 2004-05-18 | Medtronic, Inc. | Externally worn transceiver for use with an implantable medical device |
AUPR113900A0 (en) | 2000-10-31 | 2000-11-23 | Commonwealth Scientific And Industrial Research Organisation | A monitoring system |
US6632175B1 (en) | 2000-11-08 | 2003-10-14 | Hewlett-Packard Development Company, L.P. | Swallowable data recorder capsule medical device |
US6929636B1 (en) | 2000-11-08 | 2005-08-16 | Hewlett-Packard Development Company, L.P. | Internal drug dispenser capsule medical device |
ES2177434B1 (en) | 2000-12-05 | 2004-10-16 | Gesimpex Comercial, S.L. | PROCEDURE AND CAPSULE FOR REMOTE IDENTIFICATION AND MONITORING OF BIRDS. |
US6689117B2 (en) | 2000-12-18 | 2004-02-10 | Cardiac Pacemakers, Inc. | Drug delivery system for implantable medical device |
US6638231B2 (en) | 2000-12-18 | 2003-10-28 | Biosense, Inc. | Implantable telemetric medical sensor and method |
US6879810B2 (en) | 2000-12-20 | 2005-04-12 | Nokia Corporation | Control of short range RF communication |
KR100526699B1 (en) | 2001-01-17 | 2005-11-08 | 이종식 | Method and System for Network Games |
TW567695B (en) | 2001-01-17 | 2003-12-21 | Ibm | Digital baseband system |
US6771174B2 (en) | 2001-01-24 | 2004-08-03 | Intel Corporation | Digital pillbox |
GB0102725D0 (en) * | 2001-02-02 | 2001-03-21 | Stowic Resources Ltd | Medical delivery system |
JP2002224053A (en) | 2001-02-05 | 2002-08-13 | Next:Kk | Remote medical control system |
DE60230480D1 (en) | 2001-02-06 | 2009-02-05 | Draeger Medical Systems Inc | INCUBATOR FOR TOUCH-FREE MEASUREMENT AND MONITORING |
EP1379161B1 (en) | 2001-02-08 | 2006-11-08 | Mini-Mitter Company, Inc | Skin patch including a temperature sensor |
US7050419B2 (en) | 2001-02-23 | 2006-05-23 | Terayon Communicaion Systems, Inc. | Head end receiver for digital data delivery systems using mixed mode SCDMA and TDMA multiplexing |
JP2002263185A (en) | 2001-03-12 | 2002-09-17 | Sanyo Electric Co Ltd | Medicine administration system and method and medicine administration device |
JP2002282219A (en) | 2001-03-22 | 2002-10-02 | Toshio Chiba | Intracorporeal capsule |
US7072725B2 (en) * | 2001-03-26 | 2006-07-04 | Medtronic, Inc. | Implantable therapeutic substance infusion device configuration system |
JP2002290212A (en) | 2001-03-27 | 2002-10-04 | Nec Corp | Voltage controlled oscillator |
US6342774B1 (en) | 2001-03-27 | 2002-01-29 | Motorola, Inc. | Battery having user charge capacity control |
AU2002254463A1 (en) | 2001-03-28 | 2002-10-15 | Televital, Inc. | Real-time monitoring assessment, analysis, retrieval, and storage of physiological data |
JP2002282218A (en) | 2001-03-28 | 2002-10-02 | Matsushita Electric Ind Co Ltd | Portable examination terminal, examination system, communication terminal and method of examination |
JP2002291684A (en) | 2001-03-29 | 2002-10-08 | Olympus Optical Co Ltd | Endoscope for surgical operation, and outer tube |
US6595929B2 (en) | 2001-03-30 | 2003-07-22 | Bodymedia, Inc. | System for monitoring health, wellness and fitness having a method and apparatus for improved measurement of heat flow |
ATE324068T1 (en) | 2001-04-02 | 2006-05-15 | N I Medical Ltd | DEVICE FOR DETERMINING HEMODYNAMIC CONDITION |
WO2002080762A1 (en) | 2001-04-06 | 2002-10-17 | Medic4All Inc. | A physiological monitoring system for a computational device of a human subject |
GR1003802B (en) | 2001-04-17 | 2002-02-08 | Micrel �.�.�. ������� ��������� ��������������� ��������� | Tele-medicine system |
US6694161B2 (en) | 2001-04-20 | 2004-02-17 | Monsanto Technology Llc | Apparatus and method for monitoring rumen pH |
US6801137B2 (en) | 2001-04-23 | 2004-10-05 | Cardionet, Inc. | Bidirectional communication between a sensor unit and a monitor unit in patient monitoring |
US6782290B2 (en) | 2001-04-27 | 2004-08-24 | Medtronic, Inc. | Implantable medical device with rechargeable thin-film microbattery power source |
EP1385575A1 (en) | 2001-04-30 | 2004-02-04 | Medtronic, Inc. | Transcutaneous monitor and method of use, using therapeutic output from an implanted medical device |
CA2445385A1 (en) | 2001-05-03 | 2002-11-14 | Telzuit Technologies, Inc. | Wireless medical monitoring apparatus and system |
US7039033B2 (en) | 2001-05-07 | 2006-05-02 | Ixi Mobile (Israel) Ltd. | System, device and computer readable medium for providing a managed wireless network using short-range radio signals |
AU2002304269A1 (en) | 2001-05-20 | 2002-12-03 | Given Imaging Ltd. | A floatable in vivo sensing device |
US20020184415A1 (en) | 2001-05-29 | 2002-12-05 | Board Of Regents, The University Of Texas System | Health hub system and method of use |
GB0113212D0 (en) | 2001-05-31 | 2001-07-25 | Oxford Biosignals Ltd | Patient condition display |
US20020192159A1 (en) * | 2001-06-01 | 2002-12-19 | Reitberg Donald P. | Single-patient drug trials used with accumulated database: flowchart |
DE60228266D1 (en) | 2001-06-18 | 2008-09-25 | Given Imaging Ltd | SWITCHABLE IN VIVO CAPSULE WITH A RIGID AND FLEXIBLE SECTION CIRCUIT BOARD |
AP2004002960A0 (en) | 2001-06-19 | 2004-03-31 | Digital Sports Media | Physiological monitoring and system |
US6939292B2 (en) | 2001-06-20 | 2005-09-06 | Olympus Corporation | Capsule type endoscope |
US7160258B2 (en) * | 2001-06-26 | 2007-01-09 | Entrack, Inc. | Capsule and method for treating or diagnosing the intestinal tract |
US7044911B2 (en) | 2001-06-29 | 2006-05-16 | Philometron, Inc. | Gateway platform for biological monitoring and delivery of therapeutic compounds |
US7062308B1 (en) | 2001-07-05 | 2006-06-13 | Jackson William J | Remote physiological monitoring with the reticulum of livestock |
EP1414343B1 (en) | 2001-07-11 | 2009-06-03 | CNS Response, Inc. | Method for predicting outcome of treatments |
WO2003005877A2 (en) | 2001-07-12 | 2003-01-23 | Given Imaging Ltd. | Device and method for examining a body lumen |
US20030017826A1 (en) | 2001-07-17 | 2003-01-23 | Dan Fishman | Short-range wireless architecture |
US7368191B2 (en) | 2001-07-25 | 2008-05-06 | Biosource, Inc. | Electrode array for use in electrochemical cells |
FR2827919B1 (en) | 2001-07-26 | 2004-03-05 | Thermodyn | SEALING FOR COMPRESSOR AND CENTRIFUGAL COMPRESSOR PROVIDED WITH SUCH A SEAL |
US6951536B2 (en) | 2001-07-30 | 2005-10-04 | Olympus Corporation | Capsule-type medical device and medical system |
US6747556B2 (en) | 2001-07-31 | 2004-06-08 | Medtronic Physio-Control Corp. | Method and system for locating a portable medical device |
US20030037063A1 (en) | 2001-08-10 | 2003-02-20 | Qlinx | Method and system for dynamic risk assessment, risk monitoring, and caseload management |
US20030065536A1 (en) | 2001-08-13 | 2003-04-03 | Hansen Henrik Egesborg | Portable device and method of communicating medical data information |
WO2003015890A1 (en) | 2001-08-20 | 2003-02-27 | President And Fellows Of Harvard College | Fluidic arrays and method of using |
US20030040662A1 (en) * | 2001-08-22 | 2003-02-27 | Philip Keys | System, method and computer program for monitoring and managing medications |
JP3962250B2 (en) | 2001-08-29 | 2007-08-22 | 株式会社レアメタル | In vivo information detection system and tag device and relay device used therefor |
US6650191B2 (en) | 2001-09-07 | 2003-11-18 | Texas Instruments Incorporated | Low jitter ring oscillator architecture |
US6604650B2 (en) | 2001-09-28 | 2003-08-12 | Koninklijke Philips Electronics N.V. | Bottle-cap medication reminder and overdose safeguard |
US20050137480A1 (en) | 2001-10-01 | 2005-06-23 | Eckhard Alt | Remote control of implantable device through medical implant communication service band |
US6840904B2 (en) | 2001-10-11 | 2005-01-11 | Jason Goldberg | Medical monitoring device and system |
US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
US6745082B2 (en) | 2001-10-22 | 2004-06-01 | Jens Axelgaard | Current-controlling electrode with adjustable contact area |
US20030152622A1 (en) | 2001-10-25 | 2003-08-14 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral diuretic |
US20030083559A1 (en) | 2001-10-31 | 2003-05-01 | Thompson David L. | Non-contact monitor |
US7377647B2 (en) | 2001-11-13 | 2008-05-27 | Philadelphia Retina Endowment Fund | Clarifying an image of an object to perform a procedure on the object |
KR100536188B1 (en) * | 2001-11-14 | 2005-12-14 | 한국과학기술연구원 | Method and apparatus for communication between inside and outside of transmission medium such as human body utilizing itself as a communication line |
US6643541B2 (en) | 2001-12-07 | 2003-11-04 | Motorola, Inc | Wireless electromyography sensor and system |
US20030107487A1 (en) | 2001-12-10 | 2003-06-12 | Ronen Korman | Method and device for measuring physiological parameters at the wrist |
GB0130010D0 (en) * | 2001-12-14 | 2002-02-06 | Isis Innovation | Combining measurements from breathing rate sensors |
US7016648B2 (en) * | 2001-12-18 | 2006-03-21 | Ixi Mobile (Israel) Ltd. | Method, system and computer readable medium for downloading a software component to a device in a short distance wireless network |
US7729776B2 (en) | 2001-12-19 | 2010-06-01 | Cardiac Pacemakers, Inc. | Implantable medical device with two or more telemetry systems |
KR20040066177A (en) | 2001-12-19 | 2004-07-23 | 알자 코포레이션 | Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules |
US7877273B2 (en) | 2002-01-08 | 2011-01-25 | Fredric David Abramson | System and method for evaluating and providing nutrigenomic data, information and advice |
US6985870B2 (en) | 2002-01-11 | 2006-01-10 | Baxter International Inc. | Medication delivery system |
WO2003060808A2 (en) | 2002-01-11 | 2003-07-24 | Hexalog Sa | Systems and methods for medication monitoring |
JP3957272B2 (en) | 2002-01-22 | 2007-08-15 | オリンパス株式会社 | Capsule medical device |
US6980852B2 (en) | 2002-01-25 | 2005-12-27 | Subqiview Inc. | Film barrier dressing for intravascular tissue monitoring system |
US7519416B2 (en) | 2002-02-04 | 2009-04-14 | Heartview, Llc | Diagnostic method utilizing standard lead ECG signals |
IL154391A (en) | 2002-02-11 | 2009-05-04 | Given Imaging Ltd | Self propelled device |
FR2835730B1 (en) | 2002-02-11 | 2004-12-10 | C T M Ct De Transfert Des Micr | DEVICE FOR DELIVERY OF SUBSTANCES AND INTRACORPOREAL SAMPLING |
US6935560B2 (en) | 2002-02-26 | 2005-08-30 | Safety Syringes, Inc. | Systems and methods for tracking pharmaceuticals within a facility |
US20030162556A1 (en) | 2002-02-28 | 2003-08-28 | Libes Michael A. | Method and system for communication between two wireless-enabled devices |
US8660645B2 (en) | 2002-02-28 | 2014-02-25 | Greatbatch Ltd. | Electronic network components utilizing biocompatible conductive adhesives for direct body fluid exposure |
US7468032B2 (en) | 2002-12-18 | 2008-12-23 | Cardiac Pacemakers, Inc. | Advanced patient management for identifying, displaying and assisting with correlating health-related data |
US20040122296A1 (en) | 2002-12-18 | 2004-06-24 | John Hatlestad | Advanced patient management for triaging health-related data |
US7043305B2 (en) | 2002-03-06 | 2006-05-09 | Cardiac Pacemakers, Inc. | Method and apparatus for establishing context among events and optimizing implanted medical device performance |
US7081693B2 (en) | 2002-03-07 | 2006-07-25 | Microstrain, Inc. | Energy harvesting for wireless sensor operation and data transmission |
JP4363843B2 (en) | 2002-03-08 | 2009-11-11 | オリンパス株式会社 | Capsule endoscope |
US6957107B2 (en) | 2002-03-13 | 2005-10-18 | Cardionet, Inc. | Method and apparatus for monitoring and communicating with an implanted medical device |
US6968153B1 (en) | 2002-03-13 | 2005-11-22 | Nokia Corporation | Apparatus, method and system for a Bluetooth repeater |
US7188767B2 (en) * | 2002-03-18 | 2007-03-13 | Precision Dynamics Corporation | Physical condition or environmental threat detection appliance system |
US7022070B2 (en) | 2002-03-22 | 2006-04-04 | Mini-Mitter Co., Inc. | Method for continuous monitoring of patients to detect the potential onset of sepsis |
JP3869291B2 (en) | 2002-03-25 | 2007-01-17 | オリンパス株式会社 | Capsule medical device |
US6850788B2 (en) | 2002-03-25 | 2005-02-01 | Masimo Corporation | Physiological measurement communications adapter |
US7376435B2 (en) | 2002-04-01 | 2008-05-20 | Intel Corporation | Transferring multiple data units over a wireless communication link |
US7797033B2 (en) | 2002-04-08 | 2010-09-14 | Smart Pill Corporation | Method of using, and determining location of, an ingestible capsule |
US7654901B2 (en) | 2002-04-10 | 2010-02-02 | Breving Joel S | Video game system using bio-feedback devices |
IL164685A0 (en) * | 2002-04-22 | 2005-12-18 | Marcio Marc Aurelio Martins Ab | Apparatus and method for measuring biologic parameters |
WO2003089506A1 (en) | 2002-04-22 | 2003-10-30 | Purdue Research Foundation | Hydrogels having enhanced elasticity and mechanical strength properties |
EP1356762A1 (en) | 2002-04-22 | 2003-10-29 | UbiCom Gesellschaft für Telekommunikation mbH | Device for remote monitoring of body functions |
US7424268B2 (en) | 2002-04-22 | 2008-09-09 | Cisco Technology, Inc. | System and method for management of a shared frequency band |
US20030216622A1 (en) | 2002-04-25 | 2003-11-20 | Gavriel Meron | Device and method for orienting a device in vivo |
US7485093B2 (en) | 2002-04-25 | 2009-02-03 | Given Imaging Ltd. | Device and method for in-vivo sensing |
US20050055242A1 (en) * | 2002-04-30 | 2005-03-10 | Bryan Bello | System and method for medical data tracking, analysis and reporting for healthcare system |
US20040176667A1 (en) * | 2002-04-30 | 2004-09-09 | Mihai Dan M. | Method and system for medical device connectivity |
TW553735B (en) | 2002-05-01 | 2003-09-21 | Jin-Shing Luo | Common electrode using human body as common electric reservoir and application thereof |
US7368190B2 (en) | 2002-05-02 | 2008-05-06 | Abbott Diabetes Care Inc. | Miniature biological fuel cell that is operational under physiological conditions, and associated devices and methods |
US7901939B2 (en) | 2002-05-09 | 2011-03-08 | University Of Chicago | Method for performing crystallization and reactions in pressure-driven fluid plugs |
JP2003325439A (en) | 2002-05-15 | 2003-11-18 | Olympus Optical Co Ltd | Capsule type medical treatment device |
JP4187463B2 (en) | 2002-05-16 | 2008-11-26 | オリンパス株式会社 | Capsule medical device |
JP2004041709A (en) | 2002-05-16 | 2004-02-12 | Olympus Corp | Capsule medical care device |
SE0201490D0 (en) | 2002-05-17 | 2002-05-17 | St Jude Medical | Implantable Antenna |
AU2003233584A1 (en) | 2002-05-20 | 2003-12-12 | Stephen T. Flock | Device and method for wound healing and uses therefor |
JP3576150B2 (en) | 2002-05-31 | 2004-10-13 | 株式会社東芝 | Relay device and power control method |
US6847844B2 (en) | 2002-06-06 | 2005-01-25 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of data communication with implanted device and associated apparatus |
US8003179B2 (en) | 2002-06-20 | 2011-08-23 | Alcan Packaging Flexible France | Films having a desiccant material incorporated therein and methods of use and manufacture |
EP1519677B9 (en) | 2002-07-01 | 2010-08-25 | LifeSync Corporation | Wireless ecg system |
US20060129060A1 (en) | 2002-07-02 | 2006-06-15 | Healthpia America | Management method of fat mass and management device of fat mass using mobile phone |
US20040008123A1 (en) | 2002-07-15 | 2004-01-15 | Battelle Memorial Institute | System and method for tracking medical devices |
US7278983B2 (en) * | 2002-07-24 | 2007-10-09 | Medtronic Minimed, Inc. | Physiological monitoring device for controlling a medication infusion device |
US20040019172A1 (en) | 2002-07-26 | 2004-01-29 | Tou-Hsiung Yang | Biodegradable, water absorbable resin and its preparation method |
KR20100095659A (en) | 2002-07-29 | 2010-08-31 | 이데시아 엘티디. | Method and apparatus for electro-biometric identity recognition |
US7211349B2 (en) | 2002-08-06 | 2007-05-01 | Wilson Greatbatch Technologies, Inc. | Silver vanadium oxide provided with a metal oxide coating |
US20040143182A1 (en) | 2002-08-08 | 2004-07-22 | Pavel Kucera | System and method for monitoring and stimulating gastro-intestinal motility |
US6909878B2 (en) | 2002-08-20 | 2005-06-21 | Ixi Mobile (Israel) Ltd. | Method, system and computer readable medium for providing an output signal having a theme to a device in a short distance wireless network |
US7020508B2 (en) | 2002-08-22 | 2006-03-28 | Bodymedia, Inc. | Apparatus for detecting human physiological and contextual information |
US7294105B1 (en) | 2002-09-03 | 2007-11-13 | Cheetah Omni, Llc | System and method for a wireless medical communication system |
US20040049245A1 (en) | 2002-09-09 | 2004-03-11 | Volker Gass | Autonomous patch for communication with an implantable device, and medical kit for using said patch |
US7102508B2 (en) | 2002-09-09 | 2006-09-05 | Persephone, Inc. | Method and apparatus for locating and tracking persons |
GB2393356B (en) * | 2002-09-18 | 2006-02-01 | E San Ltd | Telemedicine system |
US7388903B2 (en) | 2002-09-18 | 2008-06-17 | Conexant, Inc. | Adaptive transmission rate and fragmentation threshold mechanism for local area networks |
US7118531B2 (en) | 2002-09-24 | 2006-10-10 | The Johns Hopkins University | Ingestible medical payload carrying capsule with wireless communication |
US6842636B2 (en) * | 2002-09-27 | 2005-01-11 | Axelgaard Manufacturing Co., Ltd. | Medical electrode |
US7736309B2 (en) * | 2002-09-27 | 2010-06-15 | Medtronic Minimed, Inc. | Implantable sensor method and system |
US7209790B2 (en) | 2002-09-30 | 2007-04-24 | Medtronic, Inc. | Multi-mode programmer for medical device communication |
US7686762B1 (en) | 2002-10-03 | 2010-03-30 | Integrated Sensing Systems, Inc. | Wireless device and system for monitoring physiologic parameters |
KR20050055072A (en) | 2002-10-09 | 2005-06-10 | 보디미디어 인코퍼레이티드 | Apparatus for detecting, receiving, deriving and displaying human physiological and contextual information |
US20040073454A1 (en) | 2002-10-10 | 2004-04-15 | John Urquhart | System and method of portal-mediated, website-based analysis of medication dosing |
US20050272989A1 (en) | 2004-06-04 | 2005-12-08 | Medtronic Minimed, Inc. | Analyte sensors and methods for making and using them |
US6959217B2 (en) | 2002-10-24 | 2005-10-25 | Alfred E. Mann Foundation For Scientific Research | Multi-mode crystal oscillator system selectively configurable to minimize power consumption or noise generation |
US7027871B2 (en) | 2002-10-31 | 2006-04-11 | Medtronic, Inc. | Aggregation of data from external data sources within an implantable medical device |
US20030126593A1 (en) | 2002-11-04 | 2003-07-03 | Mault James R. | Interactive physiological monitoring system |
EP1437784B1 (en) | 2002-11-08 | 2012-05-30 | Honda Motor Co., Ltd. | Electrode for solid polymer fuel cell |
US20040092801A1 (en) | 2002-11-13 | 2004-05-13 | Budimir Drakulic | System for, and method of, acquiring physiological signals of a patient |
CA2505743A1 (en) | 2002-11-14 | 2004-06-03 | Ethicon Endo-Surgery, Inc. | Methods and devices for detecting tissue cells |
AU2003282373A1 (en) | 2002-11-29 | 2004-06-23 | Given Imaging Ltd. | Methods device and system for in vivo diagnosis |
US20040115507A1 (en) | 2002-12-05 | 2004-06-17 | Potter Curtis N | Monolithic fuel cell and method of manufacture |
JP2006510655A (en) | 2002-12-11 | 2006-03-30 | ファイザー・プロダクツ・インク | Controlled release of active substances into high fat environments |
US8712549B2 (en) | 2002-12-11 | 2014-04-29 | Proteus Digital Health, Inc. | Method and system for monitoring and treating hemodynamic parameters |
US20060155174A1 (en) | 2002-12-16 | 2006-07-13 | Arkady Glukhovsky | Device, system and method for selective activation of in vivo sensors |
US20040167226A1 (en) | 2002-12-16 | 2004-08-26 | Serafini Tito A. | Methods for the treatment of pain and traumatic injury using benzamides and compositions containing the same |
US7009511B2 (en) | 2002-12-17 | 2006-03-07 | Cardiac Pacemakers, Inc. | Repeater device for communications with an implantable medical device |
CN100482296C (en) | 2002-12-19 | 2009-04-29 | 皇家飞利浦电子股份有限公司 | An electrode assembly and a system with impedance control |
US7127300B2 (en) | 2002-12-23 | 2006-10-24 | Cardiac Pacemakers, Inc. | Method and apparatus for enabling data communication between an implantable medical device and a patient management system |
US7547278B2 (en) | 2002-12-27 | 2009-06-16 | Matsushita Electric Industrial Co., Ltd. | Tele-care monitoring device |
US6975174B1 (en) | 2002-12-31 | 2005-12-13 | Radioframe Networks, Inc. | Clock oscillator |
US8771183B2 (en) | 2004-02-17 | 2014-07-08 | Abbott Diabetes Care Inc. | Method and system for providing data communication in continuous glucose monitoring and management system |
US20050154277A1 (en) | 2002-12-31 | 2005-07-14 | Jing Tang | Apparatus and methods of using built-in micro-spectroscopy micro-biosensors and specimen collection system for a wireless capsule in a biological body in vivo |
US7396330B2 (en) | 2003-01-07 | 2008-07-08 | Triage Data Networks | Wireless, internet-based medical-diagnostic system |
US20060142648A1 (en) | 2003-01-07 | 2006-06-29 | Triage Data Networks | Wireless, internet-based, medical diagnostic system |
US7512448B2 (en) | 2003-01-10 | 2009-03-31 | Phonak Ag | Electrode placement for wireless intrabody communication between components of a hearing system |
US20040147326A1 (en) | 2003-01-14 | 2004-07-29 | Stiles Thomas William | Gaming device system |
KR100522132B1 (en) | 2003-01-25 | 2005-10-18 | 한국과학기술연구원 | Data receiving method and apparatus in human body communication system |
KR100873683B1 (en) | 2003-01-25 | 2008-12-12 | 한국과학기술연구원 | Method and system for data communication in human body and capsule-type endoscope used therein |
KR20050098277A (en) | 2003-01-29 | 2005-10-11 | 이-필 파마 리미티드 | Active drug delivery in the gastrointestinal tract |
US20040267240A1 (en) | 2003-01-29 | 2004-12-30 | Yossi Gross | Active drug delivery in the gastrointestinal tract |
US7002476B2 (en) | 2003-01-30 | 2006-02-21 | Leap Of Faith Technologies, Inc. | Medication compliance system |
EP2374406B1 (en) | 2003-01-30 | 2013-06-05 | Accenture Global Services Limited | Event data acquisition and transmission system |
US7149581B2 (en) | 2003-01-31 | 2006-12-12 | Medtronic, Inc. | Patient monitoring device with multi-antenna receiver |
US7215660B2 (en) | 2003-02-14 | 2007-05-08 | Rearden Llc | Single transceiver architecture for a wireless network |
US7392015B1 (en) | 2003-02-14 | 2008-06-24 | Calamp Corp. | Calibration methods and structures in wireless communications systems |
JP4158097B2 (en) | 2003-02-27 | 2008-10-01 | ソニー株式会社 | Authentication system |
US7155232B2 (en) | 2003-03-05 | 2006-12-26 | Conexant Systems, Inc. | Transmit request signaling between transceivers |
US7653031B2 (en) * | 2003-03-05 | 2010-01-26 | Timothy Gordon Godfrey | Advance notification of transmit opportunities on a shared-communications channel |
US7321920B2 (en) | 2003-03-21 | 2008-01-22 | Vocel, Inc. | Interactive messaging system |
WO2004084720A2 (en) | 2003-03-21 | 2004-10-07 | Welch Allyn, Inc. | Personal status physiologic monitor system and architecture and related monitoring methods |
DE10313005B4 (en) | 2003-03-24 | 2007-05-03 | Siemens Ag | Backup battery and method for its manufacture |
US7245954B2 (en) | 2003-03-27 | 2007-07-17 | Given Imaging Ltd. | Measuring a gradient in-vivo |
US20040193446A1 (en) | 2003-03-27 | 2004-09-30 | Mayer Steven Lloyd | System and method for managing a patient treatment program including a prescribed drug regimen |
EP1613390A2 (en) | 2003-04-08 | 2006-01-11 | Medrad, Inc. | Fluid delivery systems, devices and methods for delivery of hazardous fluids |
GB0308114D0 (en) | 2003-04-08 | 2003-05-14 | Glaxo Group Ltd | Novel compounds |
JP4593083B2 (en) | 2003-04-11 | 2010-12-08 | オリンパス株式会社 | Inspection data management method |
GB0308467D0 (en) * | 2003-04-11 | 2003-05-21 | Rolls Royce Plc | Method and system for analysing tachometer and vibration data from an apparatus having one or more rotary components |
JP2004318534A (en) | 2003-04-16 | 2004-11-11 | Matsushita Electric Ind Co Ltd | System for supporting health promotion |
US7972616B2 (en) | 2003-04-17 | 2011-07-05 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
FI116117B (en) * | 2003-04-17 | 2005-09-30 | Polar Electro Oy | Measuring device and method for measuring heart rate and the method of manufacture of the measuring device |
WO2004096022A1 (en) | 2003-04-25 | 2004-11-11 | Olympus Corporation | Radio-type in-subject information acquisition system and device for introduction into subject |
EP1618830A4 (en) | 2003-04-25 | 2010-06-23 | Olympus Corp | Radio-type in-subject information acquisition system and outside-subject device |
US20040218683A1 (en) | 2003-05-01 | 2004-11-04 | Texas Instruments Incorporated | Multi-mode wireless devices having reduced-mode receivers |
TWI226761B (en) | 2003-05-08 | 2005-01-11 | Ind Tech Res Inst | Dual band transceiver architecture for wireless application |
US20040225199A1 (en) | 2003-05-08 | 2004-11-11 | Evanyk Shane Walter | Advanced physiological monitoring systems and methods |
US7031745B2 (en) | 2003-05-12 | 2006-04-18 | Shen Ein-Yiao | Cellular phone combined physiological condition examination and processing device |
WO2004100776A1 (en) * | 2003-05-14 | 2004-11-25 | Olympus Corporation | Capsule medical device |
US7311665B2 (en) | 2003-05-19 | 2007-12-25 | Alcohol Monitoring Systems, Inc. | Bio-information sensor monitoring system and method |
KR100542101B1 (en) | 2003-06-02 | 2006-01-11 | 삼성전자주식회사 | Power control method and bluetooth device using the same |
US20040249257A1 (en) | 2003-06-04 | 2004-12-09 | Tupin Joe Paul | Article of manufacture for extracting physiological data using ultra-wideband radar and improved signal processing techniques |
JP4399625B2 (en) | 2003-06-05 | 2010-01-20 | Qファクター株式会社 | Electronic device, quasi-electrostatic field generation method and communication system |
JP4507058B2 (en) | 2003-06-05 | 2010-07-21 | ソニー株式会社 | Distance detection system |
WO2004110555A1 (en) | 2003-06-06 | 2004-12-23 | Medtronic, Inc. | Implantable medical device including a hermetic connector block extension |
JP4414682B2 (en) | 2003-06-06 | 2010-02-10 | オリンパス株式会社 | Ultrasound endoscope device |
US7313163B2 (en) | 2003-06-17 | 2007-12-25 | Motorola, Inc. | Fast synchronization for half duplex digital communications |
US7252152B2 (en) | 2003-06-18 | 2007-08-07 | Weatherford/Lamb, Inc. | Methods and apparatus for actuating a downhole tool |
US20040260154A1 (en) | 2003-06-18 | 2004-12-23 | Boris Sidelnik | Human physiological and chemical monitoring system |
WO2004112592A1 (en) | 2003-06-24 | 2004-12-29 | Olympus Corporation | Capsule type medical device communication system, capsule type medical device, and biological information reception device |
WO2005007223A2 (en) | 2003-07-16 | 2005-01-27 | Sasha John | Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations |
CN100542477C (en) * | 2003-07-16 | 2009-09-23 | 皇家飞利浦电子股份有限公司 | A kind of portable electric appts that is used to monitor the individual physiological situation and health management system arranged |
US7554452B2 (en) | 2003-07-18 | 2009-06-30 | Cary Cole | Ingestible tracking and locating device |
US7653350B2 (en) | 2003-07-24 | 2010-01-26 | Sony Ericsson Mobile Communications Ab | Wireless terminals and methods for communicating over cellular and enhanced mode bluetooth communication links |
JP4038575B2 (en) * | 2003-07-25 | 2008-01-30 | 独立行政法人産業技術総合研究所 | Biosensor, biosensor device or biosensor storage method |
US20050021372A1 (en) | 2003-07-25 | 2005-01-27 | Dimagi, Inc. | Interactive motivation systems and methods for self-care compliance |
US7243118B2 (en) | 2003-07-30 | 2007-07-10 | Broadcom Corporation | Method and apparatus for efficient derivation of modulo arithmetic for frequency selection |
US7295877B2 (en) | 2003-07-31 | 2007-11-13 | Biosense Webster, Inc. | Encapsulated sensor with external antenna |
US20050027175A1 (en) | 2003-07-31 | 2005-02-03 | Zhongping Yang | Implantable biosensor |
US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
US20050055014A1 (en) * | 2003-08-04 | 2005-03-10 | Coppeta Jonathan R. | Methods for accelerated release of material from a reservoir device |
EP1670547B1 (en) * | 2003-08-18 | 2008-11-12 | Cardiac Pacemakers, Inc. | Patient monitoring system |
EP2382920A1 (en) * | 2003-08-20 | 2011-11-02 | Philometron, Inc. | Hydration monitoring |
US20050172958A1 (en) | 2003-08-20 | 2005-08-11 | The Brigham And Women's Hospital, Inc. | Inhalation device and system for the remote monitoring of drug administration |
US8346482B2 (en) | 2003-08-22 | 2013-01-01 | Fernandez Dennis S | Integrated biosensor and simulation system for diagnosis and therapy |
JP4398204B2 (en) | 2003-08-29 | 2010-01-13 | オリンパス株式会社 | In-subject introduction apparatus and wireless in-subject information acquisition system |
JP4332152B2 (en) | 2003-09-02 | 2009-09-16 | 富士通株式会社 | Drug administration status management method and drug |
US20050062644A1 (en) * | 2003-09-08 | 2005-03-24 | Leci Jonathan Ilan | Capsule device to identify the location of an individual |
JP3993546B2 (en) | 2003-09-08 | 2007-10-17 | オリンパス株式会社 | In-subject introduction apparatus and wireless in-subject information acquisition system |
EP3851030B1 (en) | 2003-09-11 | 2024-01-17 | Labrador Diagnostics LLC | Medical device for analyte monitoring |
US7352998B2 (en) | 2003-09-12 | 2008-04-01 | Nokia Corporation | Method and system for establishing a wireless communications link |
JP5174348B2 (en) | 2003-09-12 | 2013-04-03 | ボディーメディア インコーポレイテッド | Method and apparatus for monitoring heart related condition parameters |
US7499674B2 (en) | 2003-09-12 | 2009-03-03 | Nokia Corporation | Method and system for repeat request in hybrid ultra wideband-bluetooth radio |
JP4153852B2 (en) * | 2003-09-18 | 2008-09-24 | オリンパス株式会社 | Energy supply coil and wireless in-vivo information acquisition system using the same |
US20090157358A1 (en) | 2003-09-22 | 2009-06-18 | Hyeung-Yun Kim | System for diagnosing and monitoring structural health conditions |
EP1685456A2 (en) | 2003-09-22 | 2006-08-02 | Kim Hyeung-Yun | Sensors and systems for structural health monitoring |
US7218967B2 (en) | 2003-09-26 | 2007-05-15 | Medtronic, Inc. | System and method for real-time remote monitoring of implantable medical devices |
JP4503979B2 (en) | 2003-10-22 | 2010-07-14 | オリンパス株式会社 | Internal devices and medical devices |
US20050075145A1 (en) | 2003-10-03 | 2005-04-07 | Dvorak Joseph L. | Method and system for coordinating use of objects using wireless communications |
US8626262B2 (en) | 2003-10-30 | 2014-01-07 | Halthion Medical Technologies, Inc. | Physiological data collection system |
US20050096514A1 (en) | 2003-11-01 | 2005-05-05 | Medtronic, Inc. | Gastric activity notification |
US8095197B2 (en) | 2003-11-03 | 2012-01-10 | Microchips, Inc. | Medical device for sensing glucose |
US6892590B1 (en) | 2003-11-04 | 2005-05-17 | Andermotion Technologies Llc | Single-balanced shield electrode configuration for use in capacitive displacement sensing systems and methods |
US7101343B2 (en) | 2003-11-05 | 2006-09-05 | Temple University Of The Commonwealth System Of Higher Education | Implantable telemetric monitoring system, apparatus, and method |
US20050101843A1 (en) | 2003-11-06 | 2005-05-12 | Welch Allyn, Inc. | Wireless disposable physiological sensor |
US7415242B1 (en) | 2003-11-10 | 2008-08-19 | Sprint Spectrum L.P. | Method and system for proximity detection for an in-building wireless repeater |
DE102004032812B4 (en) | 2003-11-11 | 2006-07-20 | Dräger Safety AG & Co. KGaA | Combination sensor for physiological measurements |
JP4324858B2 (en) | 2003-11-19 | 2009-09-02 | ソニー株式会社 | Motion detection system and distance determination device |
JP4041058B2 (en) | 2003-11-20 | 2008-01-30 | 日本電信電話株式会社 | Urine test system and method and recording medium recording urine test program |
AU2004293463A1 (en) | 2003-11-20 | 2005-06-09 | Angiotech International Ag | Implantable sensors and implantable pumps and anti-scarring agents |
JP2005158770A (en) | 2003-11-20 | 2005-06-16 | Matsushita Electric Ind Co Ltd | Laminated substrate and manufacturing method thereof, manufacturing method and apparatus of module using the laminated substrate |
US20050165272A1 (en) | 2003-12-01 | 2005-07-28 | Yuta Okada | Endoscope system |
US6987691B2 (en) | 2003-12-02 | 2006-01-17 | International Business Machines Corporation | Easy axis magnetic amplifier |
US7427266B2 (en) | 2003-12-15 | 2008-09-23 | Hewlett-Packard Development Company, L.P. | Method and apparatus for verification of ingestion |
US8306592B2 (en) | 2003-12-19 | 2012-11-06 | Olympus Corporation | Capsule medical device |
JP2005185567A (en) | 2003-12-25 | 2005-07-14 | Olympus Corp | Medical capsule apparatus |
JP4198045B2 (en) | 2003-12-25 | 2008-12-17 | オリンパス株式会社 | In-subject position detection system |
US8185191B1 (en) | 2003-12-29 | 2012-05-22 | Michael Evan Shapiro | Pulse monitoring and warning system for infants |
US7392091B2 (en) | 2003-12-30 | 2008-06-24 | Cochlear Limited | Implanted antenna and radio communications link |
JP2005192821A (en) | 2004-01-07 | 2005-07-21 | Olympus Corp | Capsule type medical apparatus |
JP2005193535A (en) | 2004-01-07 | 2005-07-21 | Alps Electric Co Ltd | Thermal head, method of manufacturing the same, and method of adjusting dot aspect ratio of the thermal head |
US7081807B2 (en) | 2004-01-14 | 2006-07-25 | Joseph Lai | Automatic pill reminder bottles |
WO2005069887A2 (en) | 2004-01-16 | 2005-08-04 | The City College Of The University Of New York | Micro-scale compact device for in vivo medical diagnosis combining optical imaging and point fluorescence spectroscopy |
US7176784B2 (en) | 2004-01-21 | 2007-02-13 | Battelle Memorial Institute K1-53 | Multi-mode radio frequency device |
US7342895B2 (en) | 2004-01-30 | 2008-03-11 | Mark Serpa | Method and system for peer-to-peer wireless communication over unlicensed communication spectrum |
US7647112B2 (en) * | 2004-02-11 | 2010-01-12 | Ethicon, Inc. | System and method for selectively stimulating different body parts |
US20060154642A1 (en) | 2004-02-20 | 2006-07-13 | Scannell Robert F Jr | Medication & health, environmental, and security monitoring, alert, intervention, information and network system with associated and supporting apparatuses |
US20050187789A1 (en) * | 2004-02-25 | 2005-08-25 | Cardiac Pacemakers, Inc. | Advanced patient and medication therapy management system and method |
ATE473678T1 (en) | 2004-02-27 | 2010-07-15 | Koninkl Philips Electronics Nv | PORTABLE WIRELESS DEVICE FOR MONITORING, ANALYZING AND COMMUNICATING PHYSIOLOGICAL STATUS |
CN1284505C (en) | 2004-02-28 | 2006-11-15 | 重庆金山科技(集团)有限公司 | Radio capsule like endoscope system for medical use |
US7406105B2 (en) | 2004-03-03 | 2008-07-29 | Alfred E. Mann Foundation For Scientific Research | System and method for sharing a common communication channel between multiple systems of implantable medical devices |
JP4488315B2 (en) | 2004-03-04 | 2010-06-23 | オリンパス株式会社 | Capsule medical system |
GB0405798D0 (en) | 2004-03-15 | 2004-04-21 | E San Ltd | Medical data display |
JP5051767B2 (en) | 2004-03-22 | 2012-10-17 | ボディーメディア インコーポレイテッド | Device for monitoring human condition parameters |
JP4119863B2 (en) | 2004-03-31 | 2008-07-16 | ソフトバンクモバイル株式会社 | Information communication terminal |
JP4520198B2 (en) * | 2004-04-07 | 2010-08-04 | オリンパス株式会社 | In-subject position display system |
US20050234307A1 (en) | 2004-04-15 | 2005-10-20 | Nokia Corporation | Physiological event handling system and method |
US9011329B2 (en) * | 2004-04-19 | 2015-04-21 | Searete Llc | Lumenally-active device |
US8512219B2 (en) | 2004-04-19 | 2013-08-20 | The Invention Science Fund I, Llc | Bioelectromagnetic interface system |
JP2005304880A (en) | 2004-04-23 | 2005-11-04 | Hitachi Ltd | In-vivo object management system utilizing non-contact ic tag |
KR20070001285A (en) * | 2004-04-24 | 2007-01-03 | 인레인지 시스템즈, 인크. | Integrated, non-sequential, remote medication management and compliance system |
US20050245794A1 (en) | 2004-04-29 | 2005-11-03 | Medtronic, Inc. | Communication with implantable monitoring probe |
GB0410248D0 (en) | 2004-05-07 | 2004-06-09 | Isis Innovation | Signal analysis method |
EP1761165A4 (en) | 2004-05-10 | 2011-07-13 | Univ Minnesota | Portable device for monitoring electrocardiographic signals and indices of blood flow |
US20080051667A1 (en) * | 2004-05-16 | 2008-02-28 | Rami Goldreich | Method And Device For Measuring Physiological Parameters At The Hand |
US7575005B2 (en) | 2004-05-18 | 2009-08-18 | Excel-Tech Ltd. | Mask assembly with integrated sensors |
US20050261559A1 (en) | 2004-05-18 | 2005-11-24 | Mumford John R | Wireless physiological monitoring system |
US7125382B2 (en) | 2004-05-20 | 2006-10-24 | Digital Angel Corporation | Embedded bio-sensor system |
KR100592934B1 (en) | 2004-05-21 | 2006-06-23 | 한국전자통신연구원 | Wearable physiological signal detection module and measurement apparatus with the same |
US20050259768A1 (en) | 2004-05-21 | 2005-11-24 | Oki Techno Centre (Singapore) Pte Ltd | Digital receiver and method for processing received signals |
US7653542B2 (en) | 2004-05-26 | 2010-01-26 | Verizon Business Global Llc | Method and system for providing synthesized speech |
US20050267550A1 (en) | 2004-05-28 | 2005-12-01 | Medtronic Minimed, Inc. | System and method for medical communication device and communication protocol for same |
WO2005117697A2 (en) | 2004-05-28 | 2005-12-15 | Narayanan Ramasubramanian | Unified indigestion package and process for patient compliance with prescribed medication regimen |
DE602005004411T2 (en) * | 2004-05-28 | 2009-01-15 | Jan De Geest | COMMUNICATION UNIT FOR THE SKIN OF ONE PERSON |
US20050267556A1 (en) | 2004-05-28 | 2005-12-01 | Allan Shuros | Drug eluting implants to prevent cardiac apoptosis |
JP4666951B2 (en) | 2004-06-03 | 2011-04-06 | シーケーディ株式会社 | Blister packaging machine and pharmaceutical solid preparation |
US20060010098A1 (en) | 2004-06-04 | 2006-01-12 | Goodnow Timothy T | Diabetes care host-client architecture and data management system |
US7289855B2 (en) | 2004-06-09 | 2007-10-30 | Medtronic, Inc. | Implantable medical device package antenna |
US7283867B2 (en) | 2004-06-10 | 2007-10-16 | Ndi Medical, Llc | Implantable system and methods for acquisition and processing of electrical signals from muscles and/or nerves and/or central nervous system tissue |
US7697994B2 (en) | 2004-06-18 | 2010-04-13 | Medtronic, Inc. | Remote scheduling for management of an implantable medical device |
US7498940B2 (en) | 2004-06-22 | 2009-03-03 | Vubiq, Inc. | RFID system utilizing parametric reradiated technology |
JP2006006377A (en) | 2004-06-22 | 2006-01-12 | Elquest Corp | Powder paper for packing medicine |
KR100615431B1 (en) | 2004-06-22 | 2006-08-25 | 한국전자통신연구원 | Physiological signal detection module, a multi-channel connector module and physiological signal detection apparatus with the same |
US20050285746A1 (en) | 2004-06-25 | 2005-12-29 | Sengupta Uttam K | Radio frequency identification based system to track consumption of medication |
US20050285732A1 (en) | 2004-06-25 | 2005-12-29 | Sengupta Uttam K | Radio frequency identification based system to track consumption of medication |
US7206630B1 (en) | 2004-06-29 | 2007-04-17 | Cleveland Medical Devices, Inc | Electrode patch and wireless physiological measurement system and method |
JP4488810B2 (en) | 2004-06-30 | 2010-06-23 | 富士通株式会社 | Communication system and reception method |
US20070027383A1 (en) | 2004-07-01 | 2007-02-01 | Peyser Thomas A | Patches, systems, and methods for non-invasive glucose measurement |
US20060001496A1 (en) | 2004-07-02 | 2006-01-05 | Abrosimov Igor A | Array oscillator and polyphase clock generator |
JP4462614B2 (en) * | 2004-07-05 | 2010-05-12 | ソニー・エリクソン・モバイルコミュニケーションズ株式会社 | Short-range wireless communication system, portable terminal device, and wireless communication device |
US7505795B1 (en) | 2004-07-07 | 2009-03-17 | Advanced Micro Devices, Inc. | Power save management with customized range for user configuration and tuning value based upon recent usage |
US7343186B2 (en) | 2004-07-07 | 2008-03-11 | Masimo Laboratories, Inc. | Multi-wavelength physiological monitor |
WO2006006158A1 (en) | 2004-07-09 | 2006-01-19 | Aerotel Medical Systems (1998) Ltd. | Wearable device, system and method for measuring vital parameters |
CN1314134C (en) | 2004-07-15 | 2007-05-02 | 上海交通大学 | Method for preparing silicon thin film heterojunction solar cell |
WO2006020363A2 (en) * | 2004-07-21 | 2006-02-23 | Illumina, Inc. | Method and apparatus for drug product tracking using encoded optical identification elements |
WO2006008740A1 (en) * | 2004-07-21 | 2006-01-26 | Aerotel Medical Systems (1998) Ltd. | Wearable device, system and method for measuring physiological and/or environmental parameters |
CN100459614C (en) | 2004-07-22 | 2009-02-04 | 华为技术有限公司 | Mobile phone external device and method |
KR20060009472A (en) | 2004-07-23 | 2006-02-01 | 이기방 | Systems with water-activated battery |
US7336732B1 (en) | 2004-07-28 | 2008-02-26 | L-3 Communications Titan Corporation | Carrier frequency detection for signal acquisition |
ATE540981T1 (en) | 2004-08-11 | 2012-01-15 | Univ Ramot | SOLUBLE FUSION PROTEINS CONTAINING HETEROLOGUE POLYPEPTIDES |
US7317378B2 (en) | 2004-08-17 | 2008-01-08 | Tagent Corporation | Product identification tag device and reader |
US20060058602A1 (en) | 2004-08-17 | 2006-03-16 | Kwiatkowski Krzysztof C | Interstitial fluid analyzer |
US7253716B2 (en) | 2004-08-17 | 2007-08-07 | Tagent Corporation | Trackable pills with electronic ID tags |
US8518022B2 (en) | 2004-08-27 | 2013-08-27 | Medimetrics Personalized Drug Delivery, Inc. | Electronically and remotely controlled pill and system for delivering at least one medicament |
CN101091114A (en) | 2004-08-31 | 2007-12-19 | 生命扫描苏格兰有限公司 | Method of manufacturing an auto-calibrating sensor |
EP1799101A4 (en) | 2004-09-02 | 2008-11-19 | Proteus Biomedical Inc | Methods and apparatus for tissue activation and monitoring |
KR100727817B1 (en) * | 2004-09-07 | 2007-06-13 | 한국전자통신연구원 | The communication apparatus using the human body with the medium and method for the same |
CA2578078A1 (en) | 2004-09-08 | 2006-03-16 | Alertis Medical As | Sensor |
KR20060023228A (en) | 2004-09-09 | 2006-03-14 | 이기방 | Battery with porous material and fabrication method thereof |
GB2418144A (en) | 2004-09-17 | 2006-03-22 | Psimedica Ltd | Medical device for delivery of beneficial substance |
US20060065713A1 (en) | 2004-09-24 | 2006-03-30 | John Russell Kingery | System and method for monitored administration of medical products to patients |
US7618374B2 (en) | 2004-09-27 | 2009-11-17 | Siemens Medical Solutions Usa, Inc. | Image plane sensing methods and systems for intra-patient probes |
CN101040286B (en) | 2004-09-30 | 2012-10-03 | 皇家飞利浦电子股份有限公司 | System for automatic continuous and reliable patient identification for association of wireless medical devices to patients |
US7341560B2 (en) | 2004-10-05 | 2008-03-11 | Rader, Fishman & Grauer Pllc | Apparatuses and methods for non-invasively monitoring blood parameters |
WO2006037802A2 (en) | 2004-10-07 | 2006-04-13 | Novo Nordisk A/S | Method and system for self- management of a disease |
US20060078765A1 (en) | 2004-10-12 | 2006-04-13 | Laixia Yang | Nano-structured ion-conducting inorganic membranes for fuel cell applications |
US20060089858A1 (en) | 2004-10-25 | 2006-04-27 | Tun Ling | Means and method of applying RFID and PKI technologies for patient safety |
JP2008011865A (en) | 2004-10-27 | 2008-01-24 | Sharp Corp | Healthcare apparatus and program for driving the same to function |
US7917199B2 (en) | 2004-11-02 | 2011-03-29 | Medtronic, Inc. | Patient event marking in combination with physiological signals |
US10201305B2 (en) | 2004-11-02 | 2019-02-12 | Medtronic, Inc. | Apparatus for data retention in an implantable medical device |
AU2005229684A1 (en) | 2004-11-04 | 2006-05-18 | Given Imaging Ltd | Apparatus and method for receiving device selection and combining |
KR20060040500A (en) | 2004-11-06 | 2006-05-10 | 삼성전자주식회사 | Method and appratus for measuring bio signal |
US7414534B1 (en) | 2004-11-09 | 2008-08-19 | Pacesetter, Inc. | Method and apparatus for monitoring ingestion of medications using an implantable medical device |
US7930064B2 (en) | 2004-11-19 | 2011-04-19 | Parata Systems, Llc | Automated drug discrimination during dispensing |
US7214107B2 (en) | 2004-11-22 | 2007-05-08 | Cardiodynamics International Corporation | Electrical connector apparatus and methods |
US20080108868A1 (en) | 2004-12-02 | 2008-05-08 | Christopher Paul Swain | Device, System and Method of In-Vivo Electro-Stimulation |
US8374693B2 (en) | 2004-12-03 | 2013-02-12 | Cardiac Pacemakers, Inc. | Systems and methods for timing-based communication between implantable medical devices |
US7154071B2 (en) | 2004-12-07 | 2006-12-26 | Dräger Safety AG & Co. KGaA | Device for transmitting an electric signal detected by contact with the skin surface |
JP4234177B2 (en) | 2004-12-08 | 2009-03-04 | セイコーインスツル株式会社 | Information transmission system and transmitter / receiver via human body |
US7616710B2 (en) | 2004-12-08 | 2009-11-10 | Electronics And Telecommunications Research Institute | Frequency offset estimating method and receiver employing the same |
US20100100237A1 (en) | 2004-12-11 | 2010-04-22 | Novation Science Holding, Llc | Smart Medicine Container |
ATE545361T1 (en) | 2004-12-13 | 2012-03-15 | Koninkl Philips Electronics Nv | MOBILE MONITORING |
WO2006064502A2 (en) | 2004-12-14 | 2006-06-22 | E-Pill Pharma, Ltd. | Local delivery of drugs or substances using electronic permeability increase |
US20060136266A1 (en) | 2004-12-20 | 2006-06-22 | E-San Limited | Medicinal product order processing system |
US7860731B2 (en) | 2004-12-20 | 2010-12-28 | Confidant Hawaii, Llc | Monitoring and feedback wireless medical system and method |
JP4432766B2 (en) | 2004-12-21 | 2010-03-17 | Jfeスチール株式会社 | Electrical resistance measurement method and apparatus |
US7146449B2 (en) | 2004-12-22 | 2006-12-05 | International Business Machines Corporation | Bluetooth association with simple power connection |
US7249212B2 (en) | 2004-12-22 | 2007-07-24 | International Business Machines Corporation | Bluetooth association based on docking connection |
CN2748032Y (en) | 2004-12-30 | 2005-12-28 | 雪红梅 | Portable multifunctional health status monitoring apparatus with multi-transmission path |
DE602005007847D1 (en) | 2004-12-30 | 2008-08-14 | Given Imaging Ltd | System for localization of an in-vivo signal source |
US20060148254A1 (en) | 2005-01-05 | 2006-07-06 | Mclean George Y | Activated iridium oxide electrodes and methods for their fabrication |
WO2006075016A1 (en) | 2005-01-17 | 2006-07-20 | Novo Nordisk A/S | Fluide delivery device with integrated monitoring of physiological characteristics |
US20080194912A1 (en) | 2005-01-18 | 2008-08-14 | Koninklijke Philips Electronics, N.V. | Electronically Controlled Ingestible Capsule for Sampling Fluids in Alimentary Tract |
WO2006077528A2 (en) | 2005-01-18 | 2006-07-27 | Koninklijke Philips Electronics, N.V. | Electronically controlled capsule |
EP1841502A2 (en) | 2005-01-18 | 2007-10-10 | Koninklijke Philips Electronics N.V. | Electronically controlled capsule for releasing radiation |
CN101237903A (en) | 2005-01-18 | 2008-08-06 | 皇家飞利浦电子股份有限公司 | System and method for controlling traversal of an ingested capsule |
JP4099484B2 (en) | 2005-02-09 | 2008-06-11 | 株式会社カイザーテクノロジー | Communications system. |
JP4731936B2 (en) | 2005-02-09 | 2011-07-27 | 本田技研工業株式会社 | Rotary variable resistor |
AU2006212007A1 (en) | 2005-02-11 | 2006-08-17 | The University Court Of The University Of Glasgow | Sensing device, apparatus and system, and method for operating the same |
US7850645B2 (en) | 2005-02-11 | 2010-12-14 | Boston Scientific Scimed, Inc. | Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power |
CN101198277B (en) | 2005-02-22 | 2011-06-15 | 海尔思-斯玛特有限公司 | Systems for physiological and psycho-physiological monitoring |
US7504954B2 (en) | 2005-03-17 | 2009-03-17 | Spaeder Jeffrey A | Radio frequency identification pharmaceutical tracking system and method |
WO2006102412A2 (en) | 2005-03-21 | 2006-09-28 | Abbott Diabetes Care, Inc. | Method and system for providing integrated medication infusion and analyte monitoring system |
WO2006100620A1 (en) | 2005-03-22 | 2006-09-28 | Koninklijke Philips Electronics, N.V. | Addressing scheme for smart wireless medical sensor networks |
US20060252999A1 (en) | 2005-05-03 | 2006-11-09 | Devaul Richard W | Method and system for wearable vital signs and physiology, activity, and environmental monitoring |
US20060267774A1 (en) | 2005-03-24 | 2006-11-30 | Feinberg Stewart C | Transponder overmolded with ethylene copolymers |
US20060216603A1 (en) | 2005-03-26 | 2006-09-28 | Enable Ipc | Lithium-ion rechargeable battery based on nanostructures |
JP2006278091A (en) | 2005-03-29 | 2006-10-12 | Hitachi Maxell Ltd | Coin-shaped silver-oxide battery |
US20060224326A1 (en) | 2005-03-31 | 2006-10-05 | St Ores John W | Integrated data collection and analysis for clinical study |
GB0506925D0 (en) | 2005-04-06 | 2005-05-11 | Zarlink Semiconductor Ab | Ultra low power wake-up solution for implantable RF telemetry devices |
IL174531A0 (en) | 2005-04-06 | 2006-08-20 | Given Imaging Ltd | System and method for performing capsule endoscopy diagnosis in remote sites |
US7848820B2 (en) | 2005-04-07 | 2010-12-07 | St. Jude Medical Ab | System and method for radio communication between an implantable medical device and an external base unit |
CA3041518C (en) | 2005-04-07 | 2021-12-14 | Proteus Digital Health, Inc. | Pharma-informatics system |
EP2420185A3 (en) | 2005-04-14 | 2012-09-05 | Hidalgo Limited | Apparatus and system for monitoring |
US7270633B1 (en) | 2005-04-22 | 2007-09-18 | Cardiac Pacemakers, Inc. | Ambulatory repeater for use in automated patient care and method thereof |
US8730031B2 (en) | 2005-04-28 | 2014-05-20 | Proteus Digital Health, Inc. | Communication system using an implantable device |
US8802183B2 (en) | 2005-04-28 | 2014-08-12 | Proteus Digital Health, Inc. | Communication system with enhanced partial power source and method of manufacturing same |
US20060247505A1 (en) | 2005-04-28 | 2006-11-02 | Siddiqui Waqaas A | Wireless sensor system |
US7414543B2 (en) | 2005-04-28 | 2008-08-19 | Honeywell International Inc. | Multiple miniature avionic displays |
US9198608B2 (en) | 2005-04-28 | 2015-12-01 | Proteus Digital Health, Inc. | Communication system incorporated in a container |
US20120024889A1 (en) * | 2005-04-28 | 2012-02-02 | Timothy Robertson | Polypharmacy Co-Packaged Medication Dosing Unit Including Communication System Therefor |
EP3827747A1 (en) | 2005-04-28 | 2021-06-02 | Otsuka Pharmaceutical Co., Ltd. | Pharma-informatics system |
US8836513B2 (en) | 2006-04-28 | 2014-09-16 | Proteus Digital Health, Inc. | Communication system incorporated in an ingestible product |
US8912908B2 (en) | 2005-04-28 | 2014-12-16 | Proteus Digital Health, Inc. | Communication system with remote activation |
WO2006122179A2 (en) | 2005-05-10 | 2006-11-16 | Par Technologies Llc | Fluid container with integrated valve |
EP1880333A2 (en) | 2005-05-10 | 2008-01-23 | Cardinal Health 303, Inc. | Medication safety system featuring a multiplexed rfid interrogator panel |
US7359674B2 (en) | 2005-05-10 | 2008-04-15 | Nokia Corporation | Content distribution & communication system for enhancing service distribution in short range radio environment |
US20070222556A1 (en) | 2005-05-17 | 2007-09-27 | Robbins Gene A | Tracking system for distributable objects which are marked in single laser shot events with dynamically variable images |
JP2008540023A (en) | 2005-05-19 | 2008-11-20 | イー−ピル ファーマ リミティド | Ingestible device for nitric oxide production in tissues |
US20070088194A1 (en) | 2005-05-19 | 2007-04-19 | Eliav Tahar | Bolus, method and system for monitoring health condition of ruminant animals |
US7382263B2 (en) | 2005-05-20 | 2008-06-03 | Dow Global Technologies Inc. | Oral drug compliance monitoring using radio frequency identification tags |
US8285205B2 (en) | 2005-05-26 | 2012-10-09 | Broadcom Corporation | Method and system for a single chip integrated Bluetooth and FM transceiver and baseband processor |
US20060273882A1 (en) | 2005-06-01 | 2006-12-07 | Intel Corporation | RFID tag with separate transmit and receive clocks and related method |
US20060276702A1 (en) | 2005-06-03 | 2006-12-07 | Mcginnis William | Neurophysiological wireless bio-sensor |
US7387607B2 (en) | 2005-06-06 | 2008-06-17 | Intel Corporation | Wireless medical sensor system |
KR100695152B1 (en) | 2005-06-07 | 2007-03-14 | 삼성전자주식회사 | electrode for measuring electrocardiogram and device for measuring electrocardiogram comprising the same |
US20060287693A1 (en) | 2005-06-08 | 2006-12-21 | Clifford Kraft | Implanted telephone system |
EP1904173B8 (en) | 2005-06-09 | 2016-06-08 | Medtronic, Inc. | Implantable medical device with electrodes on multiple housing surfaces |
US20060282001A1 (en) | 2005-06-09 | 2006-12-14 | Michel Noel | Physiologic sensor apparatus |
DE102005026739A1 (en) | 2005-06-09 | 2006-12-21 | Lucas Automotive Gmbh | Devices and methods for hydraulic brake systems for land vehicles |
WO2006130988A1 (en) | 2005-06-10 | 2006-12-14 | Telecommunications Research Laboratories | Wireless communication system |
ITTO20050407A1 (en) | 2005-06-13 | 2006-12-14 | Ist Superiore Mario Boella | REMOTE MONITORING SYSTEM FOR PHYSIOLOGICAL PARAMETERS OF AN INDIVIDUAL, PROCEDURE AND IT PRODUCT |
JP2006346000A (en) | 2005-06-14 | 2006-12-28 | Aruze Corp | Game machine and server |
US20060285607A1 (en) | 2005-06-16 | 2006-12-21 | The Boeing Company | High availability narrowband channel for bandwidth efficient modulation applications |
US7782189B2 (en) | 2005-06-20 | 2010-08-24 | Carestream Health, Inc. | System to monitor the ingestion of medicines |
US7857766B2 (en) | 2005-06-20 | 2010-12-28 | Alfred E. Mann Foundation For Scientific Research | System of implantable ultrasonic emitters for preventing restenosis following a stent procedure |
US7616111B2 (en) | 2005-06-20 | 2009-11-10 | Carestream Health, Inc. | System to monitor the ingestion of medicines |
US7299034B2 (en) | 2005-06-21 | 2007-11-20 | Lawrence Kates | System and method for wearable electronics |
US20080262320A1 (en) | 2005-06-28 | 2008-10-23 | Schaefer Timothy M | System for Monitoring a Physical Parameter of a Subject |
FI20055366A0 (en) | 2005-06-30 | 2005-06-30 | Gen Electric | An electrode for obtaining a biopotential signal |
US20090134181A1 (en) | 2005-07-13 | 2009-05-28 | Vitality, Inc. | Medication dispenser with automatic refill |
US20070016089A1 (en) * | 2005-07-15 | 2007-01-18 | Fischell David R | Implantable device for vital signs monitoring |
JP5341513B2 (en) | 2005-07-20 | 2013-11-13 | ニール・アール.・イウリアーノ | Medication compliance system and related methods |
US9047746B1 (en) | 2005-07-20 | 2015-06-02 | Neil Euliano | Electronic medication compliance monitoring system and associated methods |
JP2009502248A (en) | 2005-07-22 | 2009-01-29 | ダウ グローバル テクノロジーズ インコーポレイティド | Oral drug compliance monitoring using acoustic detection |
CN100471445C (en) | 2005-08-01 | 2009-03-25 | 周常安 | Paster style physiological monitoring device, system and network |
JP4427014B2 (en) | 2005-08-02 | 2010-03-03 | セイコーインスツル株式会社 | Electronic equipment |
US20070072156A1 (en) | 2005-08-05 | 2007-03-29 | Abk Ventures | Lifestyle coach behavior modification system |
WO2007021813A2 (en) | 2005-08-11 | 2007-02-22 | Eksigent Technologies, Llc | Microfluidic system and methods |
WO2007021496A2 (en) | 2005-08-18 | 2007-02-22 | Walker Digital, Llc | Systems and methods for improved health care compliance |
WO2007023477A2 (en) | 2005-08-22 | 2007-03-01 | University Of Limerick | A tracking system |
US8116809B2 (en) | 2005-08-29 | 2012-02-14 | Intel Corporation | Method and apparatus of multiple entity wireless communication adapter |
US8827904B2 (en) * | 2005-08-31 | 2014-09-09 | Medtronic, Inc. | Automatic parameter status on an implantable medical device system |
US8547248B2 (en) | 2005-09-01 | 2013-10-01 | Proteus Digital Health, Inc. | Implantable zero-wire communications system |
JP2007068622A (en) | 2005-09-05 | 2007-03-22 | Olympus Corp | Acquisition system for biological information of subject |
JP2009507617A (en) | 2005-09-14 | 2009-02-26 | ネオガイド システムズ, インコーポレイテッド | Method and apparatus for performing transluminal and other operations |
US20070196456A1 (en) | 2005-09-15 | 2007-08-23 | Visible Assets, Inc. | Smart patch |
US7927284B2 (en) * | 2005-09-16 | 2011-04-19 | Cardiac Pacemakers, Inc. | Quantifying hemodynamic response to drug therapy using implantable sensor |
US7673679B2 (en) | 2005-09-19 | 2010-03-09 | Schlumberger Technology Corporation | Protective barriers for small devices |
US20080058614A1 (en) * | 2005-09-20 | 2008-03-06 | Triage Wireless, Inc. | Wireless, internet-based system for measuring vital signs from a plurality of patients in a hospital or medical clinic |
GB0519836D0 (en) | 2005-09-29 | 2005-11-09 | Smartlife Technology Ltd | Contact sensors |
GB0519837D0 (en) | 2005-09-29 | 2005-11-09 | Smartlife Technology Ltd | Knitting techniques |
GB0519945D0 (en) | 2005-09-30 | 2005-11-09 | Cambridge Silicon Radio Ltd | Communication in dual protocol environments |
US20070078324A1 (en) | 2005-09-30 | 2007-04-05 | Textronics, Inc. | Physiological Monitoring Wearable Having Three Electrodes |
CN100466966C (en) | 2005-10-08 | 2009-03-11 | 周常安 | Physiological signal extracting and monitoring device and system |
US7733224B2 (en) | 2006-06-30 | 2010-06-08 | Bao Tran | Mesh network personal emergency response appliance |
US9154616B2 (en) | 2005-10-18 | 2015-10-06 | Oia Intellectuals, Inc. | Wearable capture and communication |
US7720036B2 (en) | 2005-10-26 | 2010-05-18 | Intel Corporation | Communication within a wireless network using multiple frequency bands |
JP3119049U (en) * | 2005-10-27 | 2006-02-16 | 古野電気株式会社 | Medication monitoring system and medication monitoring device |
US7499739B2 (en) | 2005-10-27 | 2009-03-03 | Smiths Medical Pm, Inc. | Single use pulse oximeter |
US8515348B2 (en) | 2005-10-28 | 2013-08-20 | Electro Industries/Gauge Tech | Bluetooth-enable intelligent electronic device |
US9067047B2 (en) | 2005-11-09 | 2015-06-30 | The Invention Science Fund I, Llc | Injectable controlled release fluid delivery system |
GB0523447D0 (en) | 2005-11-17 | 2005-12-28 | E San Ltd | System and method for communicating environmentally-based medical support advice |
US20080288026A1 (en) | 2005-11-30 | 2008-11-20 | Koninklijke Philips Electronics N. V. | Electro-Mechanical Connector for Thin Medical Monitoring Patch |
US8016776B2 (en) | 2005-12-02 | 2011-09-13 | Medtronic, Inc. | Wearable ambulatory data recorder |
WO2007064924A1 (en) * | 2005-12-02 | 2007-06-07 | Medtronic, Inc. | Closed-loop therapy adjustment |
CN1991868B (en) | 2005-12-02 | 2013-02-06 | 株式会社半导体能源研究所 | Semiconductor device |
US8295932B2 (en) | 2005-12-05 | 2012-10-23 | Metacure Limited | Ingestible capsule for appetite regulation |
JP4789607B2 (en) | 2005-12-05 | 2011-10-12 | オリンパスメディカルシステムズ株式会社 | Receiver |
NL1030608C2 (en) | 2005-12-06 | 2007-06-07 | Patrick Antonius Hendri Meeren | Blister package, assembly of a blister package and a holder, and method for packaging objects. |
JP2007159631A (en) | 2005-12-09 | 2007-06-28 | Taito Corp | Game machine and game program |
US20070180047A1 (en) | 2005-12-12 | 2007-08-02 | Yanting Dong | System and method for providing authentication of remotely collected external sensor measures |
US20070135691A1 (en) | 2005-12-12 | 2007-06-14 | General Electric Company | Medicament compliance monitoring system, method, and medicament container |
CN1985752A (en) | 2005-12-19 | 2007-06-27 | 周常安 | Distributed physiological signal monitor |
ATE489079T1 (en) | 2005-12-29 | 2010-12-15 | Osmotica Kereskedelmi Es Szolgaltata Kft | MULTI-LAYER TABLET WITH TRIPLE RELEASE COMBINATION |
US7678043B2 (en) | 2005-12-29 | 2010-03-16 | Given Imaging, Ltd. | Device, system and method for in-vivo sensing of a body lumen |
US20070156016A1 (en) | 2005-12-29 | 2007-07-05 | Ido Betesh | Method and system for communication with an ingestible imaging device |
TWI306023B (en) | 2005-12-30 | 2009-02-11 | Ind Tech Res Inst | Monitoring apparatus for physical movements of a body organ and method for acouiring the same |
US8301254B2 (en) | 2006-01-09 | 2012-10-30 | Greatbatch Ltd. | Cross-band communications in an implantable device |
US20070162089A1 (en) | 2006-01-09 | 2007-07-12 | Transoma Medical, Inc. | Cross-band communications in an implantable device |
US8078278B2 (en) | 2006-01-10 | 2011-12-13 | Remon Medical Technologies Ltd. | Body attachable unit in wireless communication with implantable devices |
EP1992114B1 (en) | 2006-01-11 | 2012-11-07 | QUALCOMM Incorporated | Method and apparatus for sharing bandwidth between a wide area network and local area peer-to-peer network |
CN100571239C (en) | 2006-01-16 | 2009-12-16 | 华为技术有限公司 | Synchronizing pilot sequence generation system and method in the communication system |
US20070168222A1 (en) * | 2006-01-19 | 2007-07-19 | Hoyme Kenneth P | System and method for providing hierarchical medical device control for automated patient management |
RU2008134459A (en) | 2006-01-23 | 2010-02-27 | Конинклейке Филипс Электроникс Н.В. (Nl) | THE IMPROVED BIOMEDICAL ELECTRODE FOR THE IMPROVED CARRYING OF THE PATIENT AS A TONGUE OR BUTTON, WHICH (S) IS ISOLATED (A) FROM THE RETAINING GASKET |
US8762733B2 (en) | 2006-01-30 | 2014-06-24 | Adidas Ag | System and method for identity confirmation using physiologic biometrics to determine a physiologic fingerprint |
US20070185393A1 (en) | 2006-02-03 | 2007-08-09 | Triage Wireless, Inc. | System for measuring vital signs using an optical module featuring a green light source |
WO2007092543A2 (en) | 2006-02-06 | 2007-08-16 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive cardiac monitor and methods of using continuously recorded cardiac data |
US7809399B2 (en) | 2006-02-10 | 2010-10-05 | Syntek International Holding Ltd. | Method and device for providing multiple communication protocols with a single transceiver |
EP1993437A4 (en) * | 2006-02-24 | 2014-05-14 | Hmicro Inc | A medical signal processing system with distributed wireless sensors |
US20090023391A1 (en) | 2006-02-24 | 2009-01-22 | Koninklijke Philips Electronics N. V. | Wireless body sensor network |
US8781566B2 (en) | 2006-03-01 | 2014-07-15 | Angel Medical Systems, Inc. | System and methods for sliding-scale cardiac event detection |
US8200320B2 (en) | 2006-03-03 | 2012-06-12 | PhysioWave, Inc. | Integrated physiologic monitoring systems and methods |
US8209018B2 (en) | 2006-03-10 | 2012-06-26 | Medtronic, Inc. | Probabilistic neurological disorder treatment |
WO2007104152A2 (en) | 2006-03-14 | 2007-09-20 | Jamie Hackett | Long-range radio frequency receiver-controller module and wireless control system comprising same |
US8920343B2 (en) | 2006-03-23 | 2014-12-30 | Michael Edward Sabatino | Apparatus for acquiring and processing of physiological auditory signals |
US20070244810A1 (en) | 2006-03-27 | 2007-10-18 | Altruism In Action Llc Dba Giving Corps | Enabling a selectable charitable donation as an incentive for a customer transaction |
MX2008012587A (en) | 2006-03-29 | 2009-01-14 | Electronic Dietary Foods Inc | Ingestible implement for weight control. |
CN102323984A (en) | 2006-03-30 | 2012-01-18 | 陶氏环球技术有限责任公司 | Be used to monitor and analyze the method and system of complying with of body innerlich anwenden scheme |
US20100222642A1 (en) | 2006-03-30 | 2010-09-02 | Koninklijke Philips Electronics N.V. | Expandable digestive pill and method of use thereof |
US7806852B1 (en) | 2006-04-03 | 2010-10-05 | Jurson Phillip A | Method and apparatus for patient-controlled medical therapeutics |
TW200738212A (en) | 2006-04-12 | 2007-10-16 | Guo Terry Bo Jau | Miniature wireless apparatus for collecting physiological signals of animals |
EP2007277A4 (en) | 2006-04-18 | 2010-06-02 | Susan Mirow | Method and apparatus for analysis of psychiatric and physical conditions |
JP2009535103A (en) | 2006-04-25 | 2009-10-01 | ダウ グローバル テクノロジーズ インコーポレイティド | Compliance monitoring of oral drugs using magnetic field sensors |
US7912537B2 (en) | 2006-04-27 | 2011-03-22 | Medtronic, Inc. | Telemetry-synchronized physiological monitoring and therapy delivery systems |
MY187397A (en) | 2006-04-28 | 2021-09-22 | Qualcomm Inc | Method and apparatus for enhanced paging |
US20070255125A1 (en) | 2006-04-28 | 2007-11-01 | Moberg Sheldon B | Monitor devices for networked fluid infusion systems |
JP2009544338A (en) | 2006-05-02 | 2009-12-17 | プロテウス バイオメディカル インコーポレイテッド | Treatment regimen customized to the patient |
GB0608829D0 (en) | 2006-05-04 | 2006-06-14 | Husheer Shamus L G | In-situ measurement of physical parameters |
US7747454B2 (en) | 2006-05-06 | 2010-06-29 | Irody, Inc. | System and method for real time management of a drug regimen |
WO2007128165A1 (en) | 2006-05-09 | 2007-11-15 | Fangen Xiong | A short-range wireless networks system and erection method which allot time slots with multi-channel rf transceiver |
JP5036808B2 (en) | 2006-05-10 | 2012-09-26 | インターデイジタル テクノロジー コーポレーション | Method and apparatus for battery management in an integrated wireless transmit / receive unit |
US20080051647A1 (en) | 2006-05-11 | 2008-02-28 | Changwang Wu | Non-invasive acquisition of large nerve action potentials (NAPs) with closely spaced surface electrodes and reduced stimulus artifacts |
US7558622B2 (en) | 2006-05-24 | 2009-07-07 | Bao Tran | Mesh network stroke monitoring appliance |
US8384525B2 (en) | 2006-05-15 | 2013-02-26 | Nokia Corporation | Contactless programming and testing of memory elements |
US7539533B2 (en) | 2006-05-16 | 2009-05-26 | Bao Tran | Mesh network monitoring appliance |
US20080074307A1 (en) | 2006-05-17 | 2008-03-27 | Olga Boric-Lubecke | Determining presence and/or physiological motion of one or more subjects within a doppler radar system |
CN101073494B (en) | 2006-05-18 | 2010-09-08 | 周常安 | Non-invasive life evidence monitor, monitor system and method |
EP2029194A2 (en) | 2006-05-19 | 2009-03-04 | CVRX, Inc. | Characterization and modulation of physiologic response using baroreflex activation in conjunction with drug therapy |
US20070279217A1 (en) | 2006-06-01 | 2007-12-06 | H-Micro, Inc. | Integrated mobile healthcare system for cardiac care |
JP2009538720A (en) | 2006-06-01 | 2009-11-12 | ビアンカメッド リミテッド | Apparatus, system, and method for monitoring physiological signs |
FI120482B (en) | 2006-06-08 | 2009-11-13 | Suunto Oy | Anturointijärjestely |
US7346380B2 (en) | 2006-06-16 | 2008-03-18 | Axelgaard Manufacturing Co., Ltd. | Medical electrode |
JP2007330677A (en) | 2006-06-19 | 2007-12-27 | Nikon Corp | Chemical with built-in memory |
JP2009540932A (en) | 2006-06-21 | 2009-11-26 | プロテウス バイオメディカル インコーポレイテッド | Implantable medical device with cathodic arc fabrication structure |
WO2008076464A2 (en) | 2006-06-21 | 2008-06-26 | Surgisense Corporation | Wireless medical telemetry system and methods using radio-frequency energized biosensors |
WO2008012700A1 (en) | 2006-06-23 | 2008-01-31 | Koninklijke Philips Electronics, N.V. | Medicament delivery system |
US7949404B2 (en) | 2006-06-26 | 2011-05-24 | Medtronic, Inc. | Communications network for distributed sensing and therapy in biomedical applications |
US20080046038A1 (en) * | 2006-06-26 | 2008-02-21 | Hill Gerard J | Local communications network for distributed sensing and therapy in biomedical applications |
US8165896B2 (en) | 2006-06-29 | 2012-04-24 | The Invention Science Fund I, Llc | Compliance data for health-related procedures |
ES2326333T3 (en) | 2006-06-29 | 2009-10-07 | Edwin Kohl | PERSONALIZED BLISTER CONTAINER AND AUTOMATIC PACKAGING PROCEDURE FOR AN INDIVIDUALLY ESTABLISHED PRODUCT COMBINATION. |
US8135596B2 (en) | 2006-06-29 | 2012-03-13 | The Invention Science Fund I, Llc | Generating output data based on patient monitoring |
US20080004503A1 (en) | 2006-06-29 | 2008-01-03 | Micha Nisani | Data recorder and method for recording a data signal received from an in-vivo sensing device |
IL176712A0 (en) | 2006-07-05 | 2007-10-31 | Michael Cohen Alloro | Medication dispenser |
JP5241714B2 (en) | 2006-07-07 | 2013-07-17 | プロテウス デジタル ヘルス, インコーポレイテッド | Smart parenteral delivery system |
EP2043728A2 (en) * | 2006-07-11 | 2009-04-08 | Microchips, Inc. | Multi-reservoir pump device for dialysis, biosensing, or delivery of substances |
US20080020037A1 (en) | 2006-07-11 | 2008-01-24 | Robertson Timothy L | Acoustic Pharma-Informatics System |
US7962174B2 (en) * | 2006-07-12 | 2011-06-14 | Andrew Llc | Transceiver architecture and method for wireless base-stations |
US20080015893A1 (en) | 2006-07-17 | 2008-01-17 | Walgreen Co. | Identification of Inappropriate Medications In A Medication Therapy Regimen |
US20080021521A1 (en) * | 2006-07-18 | 2008-01-24 | Cardiac Pacemakers, Inc. | Implantable Medical Device Communication System |
DE102007020583B4 (en) | 2006-07-19 | 2012-10-11 | Erbe Elektromedizin Gmbh | Electrode device with an impedance measuring device and method for producing such an electrode device |
WO2008018076A2 (en) | 2006-08-10 | 2008-02-14 | Given Imaging Ltd. | System and method for in vivo imaging |
US20080097549A1 (en) | 2006-09-01 | 2008-04-24 | Colbaugh Michael E | Electrode Assembly and Method of Using Same |
US7756573B2 (en) | 2006-09-05 | 2010-07-13 | Cardiac Pacemakers, Inc. | Implantable medical device diagnostic data acquisition and storage |
US8615284B2 (en) | 2006-09-06 | 2013-12-24 | Innurvation, Inc. | Method for acoustic information exchange involving an ingestible low power capsule |
US8588887B2 (en) | 2006-09-06 | 2013-11-19 | Innurvation, Inc. | Ingestible low power sensor device and system for communicating with same |
CN101516256A (en) | 2006-09-18 | 2009-08-26 | 皇家飞利浦电子股份有限公司 | IP based monitoring and alarming |
US20080077430A1 (en) | 2006-09-25 | 2008-03-27 | Singer Michael S | Systems and methods for improving medication adherence |
US20080077028A1 (en) | 2006-09-27 | 2008-03-27 | Biotronic Crm Patent | Personal health monitoring and care system |
US20080077184A1 (en) | 2006-09-27 | 2008-03-27 | Stephen Denker | Intravascular Stimulation System With Wireless Power Supply |
KR100770010B1 (en) | 2006-09-29 | 2007-10-25 | 한국전자통신연구원 | Intra-body communication system for high-speed data transmission |
RU2009116271A (en) | 2006-09-29 | 2010-11-10 | Конинклейке Филипс Электроникс, Н.В. (Nl) | MINIATURE THRESHOLD SENSORS |
US20080091114A1 (en) | 2006-10-11 | 2008-04-17 | Pacesetter, Inc. | Techniques for Correlating Thoracic Impedance with Physiological Status |
US20080091089A1 (en) | 2006-10-12 | 2008-04-17 | Kenneth Shane Guillory | Single use, self-contained surface physiological monitor |
US8054140B2 (en) | 2006-10-17 | 2011-11-08 | Proteus Biomedical, Inc. | Low voltage oscillator for medical devices |
US20080097917A1 (en) | 2006-10-24 | 2008-04-24 | Kent Dicks | Systems and methods for wireless processing and medical device monitoring via remote command execution |
KR101611240B1 (en) | 2006-10-25 | 2016-04-11 | 프로테우스 디지털 헬스, 인코포레이티드 | Controlled activation ingestible identifier |
US7764996B2 (en) | 2006-10-31 | 2010-07-27 | Cardiac Pacemakers, Inc. | Monitoring of chronobiological rhythms for disease and drug management using one or more implantable device |
US8214007B2 (en) | 2006-11-01 | 2012-07-03 | Welch Allyn, Inc. | Body worn physiological sensor device having a disposable electrode module |
RU2009116834A (en) | 2006-11-09 | 2010-12-20 | Ориксиджен Терапьютикс, Инкорпорэйтд Сша/Сша (Us) | METHOD FOR ADMINISTRATION OF MEDICINES FOR REDUCING WEIGHT |
CA2928614A1 (en) | 2006-11-14 | 2008-05-22 | Cfph, Llc | Biometric access sensitivity |
US20080119705A1 (en) | 2006-11-17 | 2008-05-22 | Medtronic Minimed, Inc. | Systems and Methods for Diabetes Management Using Consumer Electronic Devices |
WO2008063626A2 (en) | 2006-11-20 | 2008-05-29 | Proteus Biomedical, Inc. | Active signal processing personal health signal receivers |
US8852172B2 (en) * | 2006-11-21 | 2014-10-07 | Medimetrics Personalized Drug Delivery | Ingestible electronic capsule and in vivo drug delivery or diagnostic system |
US8060249B2 (en) | 2006-11-22 | 2011-11-15 | Senticare Inc. | Medication dispenser with integrated monitoring system |
US8600467B2 (en) | 2006-11-29 | 2013-12-03 | Cercacor Laboratories, Inc. | Optical sensor including disposable and reusable elements |
GB0624081D0 (en) | 2006-12-01 | 2007-01-10 | Oxford Biosignals Ltd | Biomedical signal analysis method |
GB0624085D0 (en) * | 2006-12-01 | 2007-01-10 | Oxford Biosignals Ltd | Biomedical signal analysis method |
US8180425B2 (en) | 2006-12-05 | 2012-05-15 | Tyco Healthcare Group Lp | ECG lead wire organizer and dispenser |
US20080137566A1 (en) | 2006-12-06 | 2008-06-12 | Bojko Marholev | Method and System for Shared High-Power Transmit Path for a Multi-Protocol Transceiver |
JP5330259B2 (en) | 2006-12-07 | 2013-10-30 | コーニンクレッカ フィリップス エヌ ヴェ | Handheld repositionable ECG detector and method for acquiring ECG data |
US20080146889A1 (en) | 2006-12-13 | 2008-06-19 | National Yang-Ming University | Method of monitoring human physiological parameters and safty conditions universally |
US8157730B2 (en) | 2006-12-19 | 2012-04-17 | Valencell, Inc. | Physiological and environmental monitoring systems and methods |
TWI334747B (en) | 2006-12-22 | 2010-12-11 | Unimicron Technology Corp | Circuit board structure having embedded electronic components |
WO2008085131A1 (en) | 2007-01-08 | 2008-07-17 | Freesystems Pte. Ltd. | A wireless network for personal computer human interface devices |
WO2008085603A1 (en) | 2007-01-10 | 2008-07-17 | Camillo Ricordi | Mobile emergency alert system |
CA2712040A1 (en) | 2007-01-12 | 2008-07-24 | Healthhonors Corporation | Behavior modification with intermittent reward |
CA2671332A1 (en) | 2007-01-16 | 2008-07-24 | Christopher Michael Jones | Oral drug capsule component incorporating a communication device |
WO2008091838A2 (en) | 2007-01-22 | 2008-07-31 | Intelliject, Inc. | Medical injector with compliance tracking and monitoring |
US20080294020A1 (en) | 2007-01-25 | 2008-11-27 | Demetrios Sapounas | System and method for physlological data readings, transmission and presentation |
US20080183245A1 (en) | 2007-01-31 | 2008-07-31 | Van Oort Geeske | Telemetry of external physiological sensor data and implantable medical device data to a central processing system |
MY165532A (en) | 2007-02-01 | 2018-04-02 | Proteus Digital Health Inc | Ingestible event marker systems |
US20080214985A1 (en) | 2007-02-02 | 2008-09-04 | Activatek, Inc. | Active transdermal medicament patch |
JP2008191955A (en) | 2007-02-05 | 2008-08-21 | Rvision Corp | Payment charging office work representative system |
WO2008097652A2 (en) | 2007-02-08 | 2008-08-14 | Senior Vitals, Inc. | Body patch for none-invasive physiological data readings |
EP2111661B1 (en) | 2007-02-14 | 2017-04-12 | Proteus Digital Health, Inc. | In-body power source having high surface area electrode |
WO2008112577A1 (en) | 2007-03-09 | 2008-09-18 | Proteus Biomedical, Inc. | In-body device having a multi-directional transmitter |
EP2063771A1 (en) | 2007-03-09 | 2009-06-03 | Proteus Biomedical, Inc. | In-body device having a deployable antenna |
US8091790B2 (en) | 2007-03-16 | 2012-01-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Security for blister packs |
US20080303638A1 (en) | 2007-03-24 | 2008-12-11 | Hap Nguyen | Portable patient devices, systems, and methods for providing patient aid and preventing medical errors, for monitoring patient use of ingestible medications, and for preventing distribution of counterfeit drugs |
WO2008120128A2 (en) | 2007-03-30 | 2008-10-09 | Koninklijke Philips Electronics N.V. | System and method for pill communication and control |
US8810260B1 (en) | 2007-04-02 | 2014-08-19 | Cypress Semiconductor Corporation | Device and method for detecting characteristics of a material occupying a volume with capactive sensing of mirrored plates |
KR100895297B1 (en) | 2007-04-30 | 2009-05-07 | 한국전자통신연구원 | A multi channel electrode sensor apparatus for measuring a plurality of physiological signals |
US20100256461A1 (en) | 2007-05-01 | 2010-10-07 | Urodynamix Technologies Ltd. | Apparatus and methods for evaluating physiological conditions of tissue |
GB0709248D0 (en) | 2007-05-14 | 2007-06-20 | T & Medical Ltd | System for monitoring chemotherapy associated adverse drug reactions |
US8412293B2 (en) * | 2007-07-16 | 2013-04-02 | Optiscan Biomedical Corporation | Systems and methods for determining physiological parameters using measured analyte values |
US8540632B2 (en) | 2007-05-24 | 2013-09-24 | Proteus Digital Health, Inc. | Low profile antenna for in body device |
JP2008289724A (en) | 2007-05-25 | 2008-12-04 | Olympus Corp | Inspection device for capsule endoscope and capsule endoscope system using the same |
US7779614B1 (en) | 2007-05-30 | 2010-08-24 | Walgreen Co. | Method of loading a multi-dose blister card using intermediate blister cards |
US20080300572A1 (en) * | 2007-06-01 | 2008-12-04 | Medtronic Minimed, Inc. | Wireless monitor for a personal medical device system |
US20080306362A1 (en) | 2007-06-05 | 2008-12-11 | Owen Davis | Device and system for monitoring contents of perspiration |
US20080303665A1 (en) | 2007-06-08 | 2008-12-11 | Bilcare, Inc. | Package-companion-user interactive system and associated method |
US20080311968A1 (en) | 2007-06-13 | 2008-12-18 | Hunter Thomas C | Method for improving self-management of a disease |
US20080311852A1 (en) | 2007-06-15 | 2008-12-18 | Broadcom Corporation | Multiple communication link coordination for shared data transmissions |
US8060175B2 (en) | 2007-06-15 | 2011-11-15 | General Electric Company | System and apparatus for collecting physiological signals from a plurality of electrodes |
GB2450517A (en) | 2007-06-27 | 2008-12-31 | Smartlife Technology Ltd | Electrical resistance of yarn or fabric changes with temperature |
DK2170158T3 (en) | 2007-06-27 | 2017-09-18 | Hoffmann La Roche | Interface for input of patient information to a therapy system |
US8577835B2 (en) | 2007-06-28 | 2013-11-05 | Salesforce.Com, Inc. | Method and system for sharing data between subscribers of a multi-tenant database service |
CN201076456Y (en) | 2007-06-29 | 2008-06-25 | 洪金叶 | Clamp style wireless transmission pulse detection device |
US8404275B2 (en) | 2007-07-01 | 2013-03-26 | Vitalis Llc | Combination tablet with chewable outer layer |
JP5065780B2 (en) | 2007-07-03 | 2012-11-07 | 株式会社日立製作所 | RFID tag mounting board |
US20090009332A1 (en) | 2007-07-03 | 2009-01-08 | Endotronix, Inc. | System and method for monitoring ingested medication via rf wireless telemetry |
JP4520491B2 (en) | 2007-07-09 | 2010-08-04 | オリンパス株式会社 | Capsule medical system |
US8340750B2 (en) * | 2007-07-19 | 2012-12-25 | Medtronic, Inc. | Mechanical function marker channel for cardiac monitoring and therapy control |
GB0714807D0 (en) | 2007-07-30 | 2007-09-12 | Oxford Biosignals Ltd | Method and apparatus for measuring breathing rate |
JP2009034345A (en) | 2007-08-01 | 2009-02-19 | Hoya Corp | Receiver and medical equipment |
KR100863064B1 (en) | 2007-08-03 | 2008-10-13 | 한국전자통신연구원 | Garment for measuring physiological signals and method of fabricating the same |
KR101080423B1 (en) * | 2007-08-03 | 2011-11-04 | 삼성전자주식회사 | Multi module combination type portable electronic device |
US20110130658A1 (en) | 2007-08-16 | 2011-06-02 | Rdc Ltd. | Ultrasonic capsule |
US20090048498A1 (en) * | 2007-08-17 | 2009-02-19 | Frank Riskey | System and method of monitoring an animal |
US8926509B2 (en) | 2007-08-24 | 2015-01-06 | Hmicro, Inc. | Wireless physiological sensor patches and systems |
JP4914786B2 (en) | 2007-08-28 | 2012-04-11 | オリンパス株式会社 | In-subject position detection system |
US20090062670A1 (en) | 2007-08-30 | 2009-03-05 | Gary James Sterling | Heart monitoring body patch and system |
US20090062729A1 (en) | 2007-09-01 | 2009-03-05 | Sang Hoon Woo | Controlling body fluid condition using diuretics |
US20110160549A1 (en) | 2007-09-05 | 2011-06-30 | Saroka Amir | Method, system and apparatus for using electromagnetic radiation for monitoring a tissue of a user |
JP2009061236A (en) | 2007-09-07 | 2009-03-26 | Arimasa Nishida | Small terminal with functions of reading and inputting multi-data on personal medical information, of data management, analysis, and display, and of entertainment, game, and communication to facilitate self-management for health, having strong bio-feedback effect on life-style related disease, which allows unified management of measured personal data at first when developing medical information database at medical institute, or local/national government |
KR101562807B1 (en) | 2007-09-07 | 2015-11-02 | 플로레, 잉고 | Diagnostic sensor unit |
WO2009036150A2 (en) | 2007-09-11 | 2009-03-19 | Aid Networks, Llc | Wearable wireless electronic patient data communications and physiological monitoring device |
US20090076345A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Adherent Device with Multiple Physiological Sensors |
US20090076349A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Adherent Multi-Sensor Device with Implantable Device Communication Capabilities |
US8591430B2 (en) | 2007-09-14 | 2013-11-26 | Corventis, Inc. | Adherent device for respiratory monitoring |
US8460189B2 (en) | 2007-09-14 | 2013-06-11 | Corventis, Inc. | Adherent cardiac monitor with advanced sensing capabilities |
US20090076343A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Energy Management for Adherent Patient Monitor |
US20090076342A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Adherent Multi-Sensor Device with Empathic Monitoring |
WO2009036319A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Adherent emergency patient monitor |
EP4011289A1 (en) | 2007-09-25 | 2022-06-15 | Otsuka Pharmaceutical Co., Ltd. | In-body device with virtual dipole signal amplification |
US20090087483A1 (en) | 2007-09-27 | 2009-04-02 | Sison Raymundo A | Oral dosage combination pharmaceutical packaging |
EP2198552A1 (en) | 2007-09-28 | 2010-06-23 | Eye Controls, LLC. | Systems and methods for biometric identification |
US20090088618A1 (en) | 2007-10-01 | 2009-04-02 | Arneson Michael R | System and Method for Manufacturing a Swallowable Sensor Device |
WO2009051965A1 (en) | 2007-10-14 | 2009-04-23 | Board Of Regents, The University Of Texas System | A wireless neural recording and stimulating system for pain management |
US20090105561A1 (en) | 2007-10-17 | 2009-04-23 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Medical or veterinary digestive tract utilization systems and methods |
US8134459B2 (en) | 2007-10-19 | 2012-03-13 | Smiths Medical Asd, Inc. | Wireless telecommunications system adaptable for patient monitoring |
US20090105567A1 (en) | 2007-10-19 | 2009-04-23 | Smiths Medical Pm, Inc. | Wireless telecommunications network adaptable for patient monitoring |
US8139225B2 (en) | 2007-10-24 | 2012-03-20 | Siemens Medical Solutions Usa, Inc. | System for processing patient monitoring power and data signals |
GB0721117D0 (en) | 2007-10-26 | 2007-12-05 | T & Medical Ltd | system for assisting in drug dose optimisaion |
US20090112626A1 (en) | 2007-10-30 | 2009-04-30 | Cary Talbot | Remote wireless monitoring, processing, and communication of patient data |
WO2009063377A1 (en) | 2007-11-13 | 2009-05-22 | Koninklijke Philips Electronics N.V. | Ingestible electronic capsule |
US20090135886A1 (en) | 2007-11-27 | 2009-05-28 | Proteus Biomedical, Inc. | Transbody communication systems employing communication channels |
US20090143696A1 (en) | 2007-11-29 | 2009-06-04 | Integrated Sensing Systems, Inc. | Sensor unit and procedure for monitoring intracranial physiological properties |
US20090149839A1 (en) | 2007-12-11 | 2009-06-11 | Hyde Roderick A | Treatment techniques using ingestible device |
US20090287109A1 (en) | 2008-05-14 | 2009-11-19 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Circulatory monitoring systems and methods |
US20090157113A1 (en) | 2007-12-18 | 2009-06-18 | Ethicon Endo-Surgery, Inc. | Wearable elements for implantable restriction systems |
US20100036269A1 (en) | 2008-08-07 | 2010-02-11 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Circulatory monitoring systems and methods |
CN101904119B (en) | 2007-12-20 | 2015-01-28 | 皇家飞利浦电子股份有限公司 | Capacitive sensing and communicating |
JP5091657B2 (en) | 2007-12-21 | 2012-12-05 | 株式会社東芝 | Wireless communication apparatus and wireless communication method |
US20090171180A1 (en) | 2007-12-28 | 2009-07-02 | Trevor Pering | Method and apparatus for configuring wearable sensors |
WO2009091911A1 (en) | 2008-01-15 | 2009-07-23 | Cardiac Pacemakers, Inc. | Implantable medical device with antenna |
WO2009091910A1 (en) | 2008-01-15 | 2009-07-23 | Cardiac Pacemakers, Inc. | Implantable medical device with wireless communications |
US20090182207A1 (en) | 2008-01-16 | 2009-07-16 | Tenxsys Inc. | Ingestible animal health sensor |
GB2456567B (en) | 2008-01-18 | 2010-05-05 | Oxford Biosignals Ltd | Novelty detection |
JP5132335B2 (en) | 2008-01-29 | 2013-01-30 | 富士フイルム株式会社 | Capsule endoscope and capsule endoscope system |
JP5156427B2 (en) | 2008-02-13 | 2013-03-06 | 富士フイルム株式会社 | Capsule endoscope system |
US20090247836A1 (en) | 2008-02-28 | 2009-10-01 | Confidant Inc. | Medical System and Method for Serving Users with a Chronic Disease or Health State |
CN101524267A (en) | 2008-03-04 | 2009-09-09 | 黄林 | Comprehensive evaluating system and proposal for checking personal physical and psychological health |
JP2011513865A (en) | 2008-03-05 | 2011-04-28 | プロテウス バイオメディカル インコーポレイテッド | Multi-mode communication ingestible event marker and system and method of using the same |
EP2249919B1 (en) | 2008-03-06 | 2019-05-22 | Stryker Corporation | Foldable, implantable electrode array assembly |
RU2499550C2 (en) | 2008-03-10 | 2013-11-27 | Конинклейке Филипс Электроникс Н.В. | System of ecg monitoring with configured limits of switching on alarm signal |
BRPI0908741A8 (en) | 2008-03-10 | 2018-12-18 | Koninl Philips Electronics Nv | cell phone handset |
EP2262419B1 (en) | 2008-03-10 | 2019-06-26 | Koninklijke Philips N.V. | Wireless outpatient ecg monitoring system |
US20090243833A1 (en) | 2008-03-31 | 2009-10-01 | Ching Ching Huang | Monitoring system and method for patient care |
US20110163871A1 (en) | 2008-04-01 | 2011-07-07 | Shmuel Einav | Rfid monitoring of drug regimen compliance |
ATE542468T1 (en) | 2008-04-03 | 2012-02-15 | Olympus Medical Systems Corp | ANTENNA UNIT AND RECEIVING DEVICE FOR MEDICAL CAPSULE DEVICE |
EP2265169A4 (en) | 2008-04-03 | 2013-01-09 | Kai Medical Inc | Non-contact physiologic motion sensors and methods for use |
CA2758827A1 (en) | 2008-04-21 | 2009-10-29 | Philometron, Inc. | Metabolic energy monitoring system |
US8170515B2 (en) | 2008-05-21 | 2012-05-01 | Medtronic, Inc. | Method and apparatus for the phased detection of a signal including a frequency deviation detection phase |
US20090292194A1 (en) | 2008-05-23 | 2009-11-26 | Corventis, Inc. | Chiropractic Care Management Systems and Methods |
US8989837B2 (en) | 2009-12-01 | 2015-03-24 | Kyma Medical Technologies Ltd. | Methods and systems for determining fluid content of tissue |
WO2009154707A2 (en) | 2008-06-18 | 2009-12-23 | The Smartpill Corporation | System and method of evaluating a subject with an ingestible capsule |
US20090318303A1 (en) | 2008-06-20 | 2009-12-24 | International Business Machines Corporation | Microfluidic selection of library elements |
US9014778B2 (en) | 2008-06-24 | 2015-04-21 | Biosense Webster, Inc. | Disposable patch and reusable sensor assembly for use in medical device localization and mapping systems |
CH699071A2 (en) | 2008-07-02 | 2010-01-15 | Flakes S A | A braking and / or mechanical locking. |
EP2310989A4 (en) | 2008-07-07 | 2013-03-13 | Mario W Cardullo | Dynamically distributable nano rfid device and related method |
WO2010005877A2 (en) | 2008-07-08 | 2010-01-14 | Proteus Biomedical, Inc. | Ingestible event marker data framework |
US8152020B2 (en) | 2008-07-09 | 2012-04-10 | Flowers Mary E | Dosage dispensing and tracking container |
WO2010011833A1 (en) | 2008-07-23 | 2010-01-28 | Alexander Stuck | Secure tracking of tablets |
KR101214453B1 (en) | 2008-08-13 | 2012-12-24 | 프로테우스 디지털 헬스, 인코포레이티드 | Ingestible circuitry |
KR101028584B1 (en) | 2008-08-27 | 2011-04-12 | 주식회사 바이오프로테크 | Tab electrode and wire leading to the same |
US20100056878A1 (en) | 2008-08-28 | 2010-03-04 | Partin Dale L | Indirectly coupled personal monitor for obtaining at least one physiological parameter of a subject |
GB2463054A (en) | 2008-08-30 | 2010-03-03 | Adavanced Telecare Solutions L | Device for monitoring the removal of items placed in compartments of a blister package using ambient light |
US9943644B2 (en) | 2008-08-31 | 2018-04-17 | Abbott Diabetes Care Inc. | Closed loop control with reference measurement and methods thereof |
US20100063841A1 (en) | 2008-09-05 | 2010-03-11 | Vital Data Technology, Llc | System and method of notifying designated entities of access to personal medical records |
US20100069002A1 (en) | 2008-09-16 | 2010-03-18 | Vcan Sports, Inc. | Method and apparatus for a wireless communication device utilizing bluetooth technology |
CA2680952A1 (en) | 2008-10-01 | 2010-04-01 | Loyaltyone Us, Inc. | System and method for providing a health management program |
AU2009305770A1 (en) | 2008-10-14 | 2010-04-22 | Proteus Digital Health, Inc. | Method and system for incorporating physiologic data in a gaming environment |
WO2010051342A1 (en) | 2008-11-03 | 2010-05-06 | Veritrix, Inc. | User authentication for social networks |
KR101192690B1 (en) | 2008-11-13 | 2012-10-19 | 프로테우스 디지털 헬스, 인코포레이티드 | Ingestible therapy activator system, therapeutic device and method |
US20100131434A1 (en) | 2008-11-24 | 2010-05-27 | Air Products And Chemicals, Inc. | Automated patient-management system for presenting patient-health data to clinicians, and methods of operation thereor |
SG172077A1 (en) | 2008-12-11 | 2011-07-28 | Proteus Biomedical Inc | Evaluation of gastrointestinal function using portable electroviscerography systems and methods of using the same |
WO2013012869A1 (en) | 2011-07-21 | 2013-01-24 | Proteus Digital Health, Inc. | Mobile communication device, system, and method |
TWI503101B (en) | 2008-12-15 | 2015-10-11 | Proteus Digital Health Inc | Body-associated receiver and method |
US20100160742A1 (en) | 2008-12-18 | 2010-06-24 | General Electric Company | Telemetry system and method |
EP3395333A1 (en) | 2009-01-06 | 2018-10-31 | Proteus Digital Health, Inc. | Pharmaceutical dosages delivery system |
CN102341031A (en) | 2009-01-06 | 2012-02-01 | 普罗秋斯生物医学公司 | Ingestion-related biofeedback and personalized medical therapy method and system |
TW201036606A (en) | 2009-01-06 | 2010-10-16 | Proteus Biomedical Inc | High-throughput production of ingestible event markers |
KR100927471B1 (en) | 2009-01-07 | 2009-11-19 | 주식회사 두성기술 | The breast attachment type wireless heart rate apparatus |
EP2208458A1 (en) | 2009-01-14 | 2010-07-21 | Roche Diagnostics GmbH | Medical monitoring network |
US8395521B2 (en) | 2009-02-06 | 2013-03-12 | University Of Dayton | Smart aerospace structures |
US8224667B1 (en) | 2009-02-06 | 2012-07-17 | Sprint Communications Company L.P. | Therapy adherence methods and architecture |
US20100203394A1 (en) | 2009-02-06 | 2010-08-12 | In Tae Bae | Thin metal-air batteries |
US8073400B2 (en) | 2009-02-17 | 2011-12-06 | Rfaxis, Inc. | Multi mode radio frequency transceiver front end circuit |
WO2010099268A1 (en) | 2009-02-25 | 2010-09-02 | Xanthia Global Limited | Wireless physiology monitor |
US20100217100A1 (en) | 2009-02-25 | 2010-08-26 | Leboeuf Steven Francis | Methods and Apparatus for Measuring Physiological Conditions |
US8452366B2 (en) | 2009-03-16 | 2013-05-28 | Covidien Lp | Medical monitoring device with flexible circuitry |
US9161693B2 (en) | 2009-03-19 | 2015-10-20 | University Of Florida Research Foundation, Inc. | Miniaturized electronic device ingestible by a subject or implantable inside a body of the subject |
WO2010111489A2 (en) | 2009-03-27 | 2010-09-30 | LifeWatch Corp. | Methods and apparatus for processing physiological data acquired from an ambulatory physiological monitoring unit |
US8805528B2 (en) | 2009-03-31 | 2014-08-12 | Medtronic, Inc. | Channel assessment and selection for wireless communication between medical devices |
WO2010115194A1 (en) | 2009-04-03 | 2010-10-07 | Intrapace, Inc. | Feedback systems and methods for communicating diagnostic and/or treatment signals to enhance obesity treatments |
US8271106B2 (en) | 2009-04-17 | 2012-09-18 | Hospira, Inc. | System and method for configuring a rule set for medical event management and responses |
MX2011011506A (en) | 2009-04-28 | 2012-05-08 | Proteus Biomedical Inc | Highly reliable ingestible event markers and methods for using the same. |
US9149423B2 (en) | 2009-05-12 | 2015-10-06 | Proteus Digital Health, Inc. | Ingestible event markers comprising an ingestible component |
US20100299155A1 (en) | 2009-05-19 | 2010-11-25 | Myca Health, Inc. | System and method for providing a multi-dimensional contextual platform for managing a medical practice |
US8475370B2 (en) | 2009-05-20 | 2013-07-02 | Sotera Wireless, Inc. | Method for measuring patient motion, activity level, and posture along with PTT-based blood pressure |
US8440274B2 (en) | 2009-05-26 | 2013-05-14 | Apple Inc. | Electronic device moisture indicators |
US20110029622A1 (en) | 2009-06-24 | 2011-02-03 | Walker Jay S | Systems and methods for group communications |
US8468115B2 (en) | 2009-06-25 | 2013-06-18 | George Mason Intellectual Properties, Inc. | Cyclical behavior modification |
BR112012003294B1 (en) | 2009-08-14 | 2021-06-22 | Telefonaktiebolaget Lm Ericsson (Publ) | METHOD FOR ESTABLISHING A CONNECTION BETWEEN A SOURCE TERMINAL AND A DESTINATION TERMINAL, NETWORK NODE TO A CORE NETWORK, ACCESS CONNECTION POINT OF A CORE NETWORK, HOLDER OF ELECTRONICALLY LEGIBLE DATA, AND, COMPUTING STORAGE MEANS |
US9024766B2 (en) | 2009-08-28 | 2015-05-05 | The Invention Science Fund, Llc | Beverage containers with detection capability |
JP5006474B2 (en) | 2009-08-28 | 2012-08-22 | オリンパスメディカルシステムズ株式会社 | Receiving system |
ES2912584T3 (en) | 2009-08-31 | 2022-05-26 | Abbott Diabetes Care Inc | A glucose monitoring system and method |
US20110230732A1 (en) | 2009-09-14 | 2011-09-22 | Philometron, Inc. | System utilizing physiological monitoring and electronic media for health improvement |
US20110077719A1 (en) | 2009-09-30 | 2011-03-31 | Broadcom Corporation | Electromagnetic power bio-medical unit |
US8879994B2 (en) | 2009-10-02 | 2014-11-04 | Blackberry Limited | Methods and devices for facilitating Bluetooth pairing using a camera as a barcode scanner |
JP2011076034A (en) | 2009-10-02 | 2011-04-14 | Sony Corp | Image display device and method for driving the same |
US20110270112A1 (en) | 2009-11-02 | 2011-11-03 | Applied Cardiac Systems, Inc. | Multi-Function Health Monitor |
TWI517050B (en) | 2009-11-04 | 2016-01-11 | 普羅托斯數位健康公司 | System for supply chain management |
US8838217B2 (en) | 2009-11-10 | 2014-09-16 | Makor Issues And Rights Ltd. | System and apparatus for providing diagnosis and personalized abnormalities alerts and for providing adaptive responses in clinical trials |
US20110112686A1 (en) | 2009-11-10 | 2011-05-12 | Nolan James S | Devices and methods and systems for determining and/or indicating a medicament dosage regime |
US20110270135A1 (en) | 2009-11-30 | 2011-11-03 | Christopher John Dooley | Augmented reality for testing and training of human performance |
UA109424C2 (en) | 2009-12-02 | 2015-08-25 | PHARMACEUTICAL PRODUCT, PHARMACEUTICAL TABLE WITH ELECTRONIC MARKER AND METHOD OF MANUFACTURING PHARMACEUTICAL TABLETS | |
TW201120673A (en) | 2009-12-11 | 2011-06-16 | Univ Ling Tung | Medication reminder and physiological information transmission system, and follow-up visit reminder and physiological information transmission system. |
US9451897B2 (en) | 2009-12-14 | 2016-09-27 | Medtronic Monitoring, Inc. | Body adherent patch with electronics for physiologic monitoring |
EP2896356A1 (en) | 2009-12-23 | 2015-07-22 | DELTA, Dansk Elektronik, Lys & Akustik | A monitoring system |
US8560040B2 (en) | 2010-01-04 | 2013-10-15 | Koninklijke Philips N.V. | Shielded biomedical electrode patch |
KR101034998B1 (en) | 2010-02-18 | 2011-05-17 | 대한메디칼시스템(주) | Connecting structure for snap electrode and electric wire |
US9075910B2 (en) | 2010-03-11 | 2015-07-07 | Philometron, Inc. | Physiological monitor system for determining medication delivery and outcome |
US9872637B2 (en) | 2010-04-21 | 2018-01-23 | The Rehabilitation Institute Of Chicago | Medical evaluation system and method using sensors in mobile devices |
WO2011143490A2 (en) | 2010-05-12 | 2011-11-17 | Irhythm Technologies, Inc. | Device features and design elements for long-term adhesion |
WO2011146708A2 (en) | 2010-05-21 | 2011-11-24 | Medicomp, Inc. | Retractable multi-use cardiac monitor |
US8301232B2 (en) | 2010-06-08 | 2012-10-30 | Alivecor, Inc. | Wireless, ultrasonic personal health monitoring system |
US20110301439A1 (en) | 2010-06-08 | 2011-12-08 | AliveUSA LLC | Wireless, ultrasonic personal health monitoring system |
CN103154929A (en) | 2010-06-14 | 2013-06-12 | 特鲁塔格科技公司 | System for producing a packaged item with an identifier |
WO2011159337A1 (en) | 2010-06-14 | 2011-12-22 | Trutag Technologies, Inc. | Labeling and verifying an item with an identifier |
WO2011159338A1 (en) | 2010-06-14 | 2011-12-22 | Trutag Technologies, Inc. | System for verifying an item in a package |
CN106408309A (en) | 2010-06-14 | 2017-02-15 | 特鲁塔格科技公司 | System for verifying an item in a package using a database |
KR20110137001A (en) | 2010-06-16 | 2011-12-22 | (주)유카이트 | Health risk warning system |
US20130196012A1 (en) | 2010-11-30 | 2013-08-01 | Wellesley Pharmaceuticals, Llc | Extended-release formulation for reducing the frequency of urination and method of use thereof |
US9585620B2 (en) | 2010-07-27 | 2017-03-07 | Carefusion 303, Inc. | Vital-signs patch having a flexible attachment to electrodes |
EP2616905A4 (en) | 2010-09-13 | 2017-11-29 | Nokia Technologies Oy | Haptic communication |
WO2012040388A2 (en) | 2010-09-21 | 2012-03-29 | Somaxis Incorporated | Metrics and algorithms for interpretation of muscular use |
US9167991B2 (en) | 2010-09-30 | 2015-10-27 | Fitbit, Inc. | Portable monitoring devices and methods of operating same |
USD639437S1 (en) | 2010-10-08 | 2011-06-07 | Cardiac Science Corporation | Wearable ambulatory electrocardiographic monitor |
US20120089000A1 (en) | 2010-10-08 | 2012-04-12 | Jon Mikalson Bishay | Ambulatory Electrocardiographic Monitor For Providing Ease Of Use In Women And Method Of Use |
TW201219006A (en) | 2010-11-05 | 2012-05-16 | Univ Nat Cheng Kung | A peripheral physiology inspection apparatus and a peripheral auxiliary device for smart phone |
US8823510B2 (en) | 2010-12-23 | 2014-09-02 | Klindown, Llc | Systems and methods for wirelessly programming a prescription bottle cap |
CN102753088B (en) | 2011-01-18 | 2014-08-27 | 北京超思电子技术股份有限公司 | Measuring apparatus |
US20120197144A1 (en) | 2011-01-27 | 2012-08-02 | Koninklijke Philips Electronics N.V. | Exchangeable electrode and ecg cable snap connector |
GB2487758A (en) | 2011-02-03 | 2012-08-08 | Isansys Lifecare Ltd | Health monitoring electrode assembly |
US8966973B1 (en) | 2011-02-15 | 2015-03-03 | Christopher J. Milone | Low cost capacitive liquid level sensor |
KR101836876B1 (en) | 2011-03-02 | 2018-03-09 | 삼성전자주식회사 | Apparatus and method for performing network connection in portable terminal |
US9439599B2 (en) | 2011-03-11 | 2016-09-13 | Proteus Digital Health, Inc. | Wearable personal body associated device with various physical configurations |
US10853819B2 (en) | 2011-04-14 | 2020-12-01 | Elwha Llc | Cost-effective resource apportionment technologies suitable for facilitating therapies |
US9189941B2 (en) | 2011-04-14 | 2015-11-17 | Koninklijke Philips N.V. | Stepped alarm method for patient monitors |
US9756874B2 (en) | 2011-07-11 | 2017-09-12 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
WO2015112603A1 (en) | 2014-01-21 | 2015-07-30 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
US9235683B2 (en) | 2011-11-09 | 2016-01-12 | Proteus Digital Health, Inc. | Apparatus, system, and method for managing adherence to a regimen |
US20140315170A1 (en) | 2011-11-23 | 2014-10-23 | Proteus Digital Health, Inc. | Apparatus, System, and Method to Promote Behavior Change Based on Mindfulness Methodologies |
US20130171596A1 (en) | 2012-01-04 | 2013-07-04 | Barry J. French | Augmented reality neurological evaluation method |
US8908943B2 (en) | 2012-05-22 | 2014-12-09 | Orca Health, Inc. | Personalized anatomical diagnostics and simulations |
US9277864B2 (en) | 2012-05-24 | 2016-03-08 | Vital Connect, Inc. | Modular wearable sensor device |
US20140039445A1 (en) | 2012-08-06 | 2014-02-06 | Xerox Corporation | Computer-based reusable bidirectional medical adherence system and method for personalized medication packaging |
US20140280125A1 (en) | 2013-03-14 | 2014-09-18 | Ebay Inc. | Method and system to build a time-sensitive profile |
US20140308930A1 (en) | 2013-04-12 | 2014-10-16 | Bao Tran | Timely, glanceable information on a wearable device |
US9529385B2 (en) | 2013-05-23 | 2016-12-27 | Medibotics Llc | Smart watch and human-to-computer interface for monitoring food consumption |
JP6511439B2 (en) | 2013-06-04 | 2019-05-15 | プロテウス デジタル ヘルス, インコーポレイテッド | Systems, devices, and methods for data collection and outcome assessment |
US10545132B2 (en) | 2013-06-25 | 2020-01-28 | Lifescan Ip Holdings, Llc | Physiological monitoring system communicating with at least a social network |
US9517012B2 (en) | 2013-09-13 | 2016-12-13 | Welch Allyn, Inc. | Continuous patient monitoring |
US10084880B2 (en) | 2013-11-04 | 2018-09-25 | Proteus Digital Health, Inc. | Social media networking based on physiologic information |
US20150127738A1 (en) | 2013-11-05 | 2015-05-07 | Proteus Digital Health, Inc. | Bio-language based communication system |
US20150149375A1 (en) | 2013-11-22 | 2015-05-28 | Proteus Digital Health, Inc. | Crowd endorsement system |
US9226663B2 (en) | 2014-04-07 | 2016-01-05 | Physical Enterprises, Inc. | Systems and methods for optical isolation in measuring physiological parameters |
-
2007
- 2007-05-02 JP JP2009509700A patent/JP2009544338A/en not_active Withdrawn
- 2007-05-02 CN CN201510684519.0A patent/CN105468895A/en active Pending
- 2007-05-02 CA CA2650920A patent/CA2650920C/en active Active
- 2007-05-02 WO PCT/US2007/010688 patent/WO2007130491A2/en active Application Filing
- 2007-05-02 US US12/299,303 patent/US8956287B2/en active Active
- 2007-05-02 KR KR1020147002012A patent/KR20140018439A/en not_active Application Discontinuation
- 2007-05-02 EP EP18167390.6A patent/EP3367386A1/en active Pending
- 2007-05-02 KR KR1020087029427A patent/KR101568660B1/en active IP Right Grant
- 2007-05-02 CN CNA2007800244235A patent/CN101496042A/en active Pending
- 2007-05-02 EP EP07776655A patent/EP2013829A4/en not_active Ceased
-
2008
- 2008-11-02 IL IL195052A patent/IL195052A/en active IP Right Grant
-
2013
- 2013-04-19 JP JP2013088115A patent/JP5864472B2/en active Active
-
2014
- 2014-12-29 US US14/584,736 patent/US20150193593A1/en not_active Abandoned
-
2015
- 2015-07-02 JP JP2015133266A patent/JP2015213775A/en not_active Withdrawn
-
2017
- 2017-09-28 US US15/719,498 patent/US11928614B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
IL195052A0 (en) | 2009-08-03 |
WO2007130491A3 (en) | 2008-01-03 |
JP5864472B2 (en) | 2016-02-17 |
EP2013829A2 (en) | 2009-01-14 |
KR20090033837A (en) | 2009-04-06 |
KR101568660B1 (en) | 2015-11-12 |
KR20140018439A (en) | 2014-02-12 |
EP3367386A1 (en) | 2018-08-29 |
WO2007130491A2 (en) | 2007-11-15 |
US20150193593A1 (en) | 2015-07-09 |
CN101496042A (en) | 2009-07-29 |
JP2009544338A (en) | 2009-12-17 |
JP2013157026A (en) | 2013-08-15 |
CA2650920A1 (en) | 2007-11-15 |
CN105468895A (en) | 2016-04-06 |
JP2015213775A (en) | 2015-12-03 |
IL195052A (en) | 2016-08-31 |
US11928614B2 (en) | 2024-03-12 |
US20090076338A1 (en) | 2009-03-19 |
EP2013829A4 (en) | 2010-07-07 |
US8956287B2 (en) | 2015-02-17 |
US20180089393A1 (en) | 2018-03-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11928614B2 (en) | Patient customized therapeutic regimens | |
US20230386628A1 (en) | Electronic Patient Monitoring System | |
US20220016337A1 (en) | Pump infusion system | |
AU2004305087B2 (en) | Intravenous medication harm index system | |
US8290792B2 (en) | Prescription compliance monitoring system | |
Au-Yeung et al. | A networked system for self-management of drug therapy and wellness | |
US20060089545A1 (en) | System and method for presenting and distributing medication information | |
JP2007524175A (en) | Advanced patient management and medication management systems and methods | |
AU2004296021A1 (en) | System and method for analyzing medical treatment data | |
WO2005009514A2 (en) | A communications system for an implantable medical device and a delivery device | |
EP2585986A1 (en) | Medication compliance system and method | |
US11160730B2 (en) | Smart medication dispensing system and method | |
US20220280391A1 (en) | Medication dispensing machine and system | |
JP2018511110A (en) | System, device and method for detecting and analyzing ingestible events | |
NZ570531A (en) | Medication management and event logger analysis system |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |